Hub : Genes

Sac3d1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Sac3d1	0.18	0.08	0.0e+00	0.13	0.14	0.14	0.14	3.9e-14	1.4e-15	6.5e-15	9.0e-15
2	Brain	gene expression	Sac3d1	0.15	0.1	1.6e-05	0.06	0.06	0.04	0.05	5.2e-06	3.2e-06	6.6e-05	1.2e-05
3	NAcc	gene expression	Sac3d1	0.39	0.11	0.0e+00	0.25	0.24	0.24	0.24	6.2e-29	8.5e-28	1.9e-27	3.9e-28
4	Brain	mRNA stability	Sac3d1	0.04	0.03	6.0e-03	0.01	0.02	0.02	0.01	2.4e-02	3.7e-03	8.3e-03	2.2e-02
5	PL	gene expression	Sac3d1	0.06	0.03	7.6e-05	0.05	0.05	0.04	0.04	5.1e-06	8.3e-06	1.1e-05	8.7e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	1.7	2.8	3.9	-1.0	1.8	-2.0	-1.6	-1.8
Area under the delay curve	0.1	0.1	0.7	0.2	-0.1	0.0	0.0	-0.8
BMI with tail	6.4	20.8	29.5	-3.3	5.2	-5.4	-3.5	-4.9
BMI without tail	2.4	4.9	6.9	-1.7	2.6	-2.6	-1.3	-2.5
Body weight	3.2	13.5	21.2	-4.3	4.6	-3.9	-2.2	-2.7
Weight adjusted by age	1.3	1.5	3.5	-1.9	1.4	-1.0	-0.9	-0.5
Bone surface	6.1	10.7	14.1	-3.4	3.8	-3.4	-3.2	-2.5
Bone volume	4.0	6.8	8.5	-2.2	2.8	-2.8	-2.9	-2.3
Breakpoint value in progressive ratio session	2.0	2.2	4.8	-2.2	1.5	-1.0	-1.2	-1.1
Number of licking bursts	0.3	0.3	0.4	-0.7	0.5	-0.4	-0.6	-0.6
Context. condit. distance diff. score	0.9	1.1	2.9	1.7	-1.1	0.7	0.8	0.6
Locomotion velocity, session 1	0.3	0.4	0.9	0.1	-0.1	0.3	0.9	0.9
Locomotion distance, session 1	0.7	0.8	1.5	-0.7	1.2	-1.2	-0.4	-0.8
Locomotion velocity, session 2	2.4	2.8	4.1	-2.0	2.0	-1.7	-1.0	-1.5
Locomotion distance, session 2	0.5	0.7	1.1	-0.8	1.1	-1.0	-0.2	-0.9
Locomotion velocity, session 3	0.5	0.6	1.6	0.4	0.8	-1.3	-0.3	-0.8
Locomotion distance, session 3	0.0	0.0	0.1	0.3	-0.0	-0.0	0.2	0.2
Stereotopy head waving bouts, day 3	0.5	0.5	1.4	0.8	0.6	-1.2	0.0	-0.4
Stereotopy head waving duration, day 3	0.2	0.2	0.8	0.9	0.1	-0.6	-0.0	-0.3
Locomotion velocity, session 7	1.0	1.1	2.3	0.6	0.7	-1.2	-0.9	-1.5
Locomotion distance, session 7	0.1	0.1	0.3	0.5	0.2	-0.4	0.3	-0.4
Stereotopy head waving bouts, day 7	0.7	0.8	1.8	0.0	0.4	-0.8	-1.2	-1.3
Stereotopy head waving duration, day 7	2.1	2.5	4.0	-1.4	1.4	-1.3	-1.7	-2.0
Locomotion velocity, session 8	0.3	0.4	0.7	-0.8	0.6	-0.2	0.8	0.3
Locomotion distance, session 8	0.3	0.5	1.2	0.4	0.7	-1.1	-0.4	-0.6
Degree of sensitization distance	0.4	0.4	1.1	0.2	0.8	-1.0	-0.3	-0.4
Degree of sensitization stereotypy	1.5	1.7	2.8	-1.1	1.0	-1.0	-1.6	-1.7
Conditioned locomotion	0.7	0.8	1.9	-1.4	1.2	-0.8	-0.2	0.1
Cocaine response after cond. corrected	1.1	1.3	2.7	1.6	-0.9	0.6	1.3	0.9
Cocaine response after cond. not corrected	0.8	0.8	1.9	1.4	-0.7	0.3	1.1	0.8
Cocaine response before conditioning	0.6	0.8	1.4	-1.2	0.8	-0.6	-1.0	-0.7
Saline control response	1.5	2.0	5.3	-2.3	1.8	-1.1	-0.2	-0.5
Bone: connectivity density	3.2	5.1	6.5	-2.2	2.6	-2.4	-1.9	-2.2
Bone: cortical apparent density	0.3	0.4	1.1	-0.3	-0.6	1.0	0.5	-0.1
Bone: cortical area	0.8	1.2	1.7	-1.3	1.3	-1.1	-1.1	-0.4
Bone: cortical porosity	0.5	0.5	1.3	-0.3	0.6	-0.6	-0.6	-1.2
Bone: cortical porosity	0.6	0.7	1.2	-0.9	0.9	-0.7	-0.5	-1.1
Bone: cortical thickness	0.5	0.9	3.4	-1.9	0.5	0.3	0.6	0.5
Bone: cortical thickness	1.0	1.2	2.3	-0.3	-0.5	1.1	1.5	1.5
Bone: cortical tissue density	0.3	0.4	1.2	-0.4	-0.6	1.1	0.5	-0.0
Condit. Reinf. active minus inactive responses	0.1	0.1	0.3	-0.3	0.2	-0.1	-0.1	-0.5
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.4	-0.0	-0.5	0.6	0.2	-0.1
Condit. Reinf. active responses	0.3	0.3	0.6	-0.2	0.6	-0.7	-0.6	-0.5
Condit. Reinf. inactive responses	0.8	0.9	2.2	-0.0	1.1	-1.5	-1.1	-0.4
Incentive salience index mean	0.5	0.6	0.9	-0.6	0.9	-0.9	-0.6	-0.9
Condit. Reinf. lever presses	1.0	1.4	2.5	-0.9	1.5	-1.6	-1.1	-0.5
Condit. Reinf. active minus inactive responses	0.3	0.3	0.9	0.1	0.2	-0.5	-1.0	-0.7
Condit. Reinf. active-inactive response ratio	1.1	1.2	2.8	0.3	0.7	-1.3	-1.7	-0.9
Condit. Reinf. active responses	0.3	0.4	1.0	-0.3	0.2	-0.3	-0.8	-1.0
Condit. Reinf. inactive responses	0.1	0.2	0.3	-0.3	-0.2	0.5	0.4	-0.6
Condit. Reinf. lever presses	2.5	3.5	4.5	-2.1	1.9	-1.6	-1.9	-1.6
Condit. Reinf. lever reinforcers received	0.4	0.5	0.9	-0.7	0.4	-0.4	-0.9	-1.0
Conditioned reinforcement - actives	0.2	0.2	0.6	0.1	0.0	-0.1	-0.8	0.4
Conditioned reinforcement - inactives	2.7	3.1	5.9	2.4	-2.2	1.7	-0.1	1.3
Conditioned locomotion	4.7	5.7	10.6	3.2	-2.8	2.1	0.9	2.1
Patch foraging indifference point 0 sec	0.0	0.0	0.1	0.3	-0.2	0.1	-0.0	0.0
Patch foraging indifference point AUC	1.9	2.1	5.7	-2.4	1.4	-0.9	-1.2	-0.8
Delay disc. indifference point, 0s delay	0.2	0.2	0.4	0.6	-0.2	-0.0	0.4	-0.5
Delay disc. indifference point, 16s delay	0.5	0.5	0.8	0.9	-0.7	0.5	-0.4	-0.8
Delay disc. indifference point, 2s delay	0.1	0.1	0.2	0.1	0.3	-0.4	-0.3	-0.3
Delay disc. indifference point, 24s delay	0.7	0.7	1.3	0.5	-0.8	1.0	1.1	0.5
Delay disc. indifference point, 4s delay	0.2	0.2	0.5	0.5	-0.4	0.3	0.7	-0.2
Delay disc. indifference point, 8s delay	0.2	0.2	0.5	0.4	-0.3	0.3	0.7	-0.1
Indifference point function ln k	5.5	7.7	16.9	4.1	-2.8	1.9	2.5	2.1
Indifference point function log k	5.5	7.7	16.9	4.1	-2.8	1.9	2.5	2.1
Patch foraging total patch changes 0 sec	0.1	0.2	0.3	0.3	-0.4	0.5	0.5	0.5
Patch foraging total patch changes 12 sec	2.4	3.1	7.1	-2.7	1.8	-1.2	-1.2	-1.5
Patch foraging total patch changes 18 sec	0.9	1.2	1.3	-1.1	1.0	-0.9	-1.1	-1.2
Patch foraging total patch changes 24 sec	0.8	1.0	3.5	-1.9	1.0	-0.4	-0.3	0.0
Patch foraging total patch changes 6 sec	0.4	0.5	1.1	-1.1	0.9	-0.6	-0.2	-0.5
Patch foraging time to switch 0 sec	4.6	7.1	10.2	-2.1	2.7	-2.7	-2.5	-3.2
Patch foraging water rate 0 sec	5.2	8.3	11.4	2.9	-3.0	2.7	2.3	3.4
Patch foraging water rate 12 sec	10.7	16.4	18.6	4.3	-4.2	3.8	3.9	4.1
Patch foraging water rate 18 sec	3.5	4.8	6.6	2.6	-2.0	1.6	2.2	2.4
Patch foraging water rate 24 sec	4.2	5.8	7.6	2.8	-2.4	1.9	2.2	2.7
Patch foraging water rate 6 sec	5.8	8.4	10.2	3.1	-2.8	2.4	3.0	3.2
Seeking ratio, delayed vs. immediate footshock	0.1	0.2	0.4	0.4	-0.4	0.1	-0.0	-0.6
Distance traveled before self-admin	1.0	1.0	1.5	-1.2	1.0	-0.8	-1.2	-0.8
Distance traveled after self-admin	0.2	0.2	0.4	-0.6	0.2	-0.1	-0.6	-0.4
Extensor digitorum longus weight	4.5	17.7	35.0	-5.9	5.1	-3.8	-2.4	-2.7
Bone: elastic displacement	3.9	4.5	6.5	1.6	-1.9	1.9	2.4	2.6
Bone: elastic work	0.8	1.1	2.6	-0.4	-0.1	0.6	1.5	1.6
Bone: endosteal estimation	1.1	2.5	5.7	0.7	1.4	-2.4	-1.7	-1.2
Bone: endosteal perimeter	1.6	3.2	6.3	0.6	1.5	-2.5	-2.3	-1.4
Epididymis fat weight	0.5	1.2	5.2	2.3	-0.8	-0.2	-0.3	0.3
Delta time in closed arm before/after self-admin	0.8	0.7	2.6	0.4	-0.2	0.3	1.6	0.8
Delta time in open arm before/after self-admin	0.3	0.3	1.1	-0.6	0.0	0.1	-1.1	-0.3
Diff in mean of infusions in LGA sessions	0.1	0.1	0.5	-0.7	0.0	0.2	-0.0	0.3
Delay discount exponential model param	0.1	0.1	0.5	-0.2	0.1	-0.1	-0.1	0.7
Extinction: sum of active levers before priming	3.7	3.7	5.9	-2.4	2.0	-1.5	-1.5	-2.1
Active lever presses in extinction session 6	1.7	1.7	4.3	-2.1	1.4	-0.9	-1.1	-0.1
Bone: final force	2.7	4.4	6.8	-2.6	2.6	-2.2	-1.6	-1.1
Bone: final moment	2.4	4.0	6.2	-2.4	2.5	-2.1	-1.5	-1.0
Food consumed during 24 hour testing period	0.1	0.2	0.3	-0.3	-0.4	0.5	-0.1	0.6
Glucose	0.5	0.8	2.4	1.6	-0.0	-0.8	-0.6	-0.5
Heart weight	1.6	2.3	6.5	2.6	-1.6	0.9	1.0	0.7
Delay discount hyperbolic model param	0.1	0.1	0.4	-0.1	0.1	-0.1	-0.1	0.6
Intermittent access intake day 1-15 change	0.6	0.6	1.1	0.6	-0.9	0.8	-0.1	1.0
Intermittent access intake escalation	0.3	0.3	0.5	0.6	-0.7	0.6	-0.2	0.7
Intermittent access intake escalation 2	0.4	0.4	0.7	0.1	-0.7	0.8	-0.2	0.8
Intermitt. access day 1 inactive lever presses	1.0	1.1	2.7	1.6	-1.3	1.0	0.1	0.4
Intermitt. access day 15 inactive lever presses	0.8	0.9	2.2	1.5	-1.1	0.7	-0.6	0.5
Intermitt. access escalation Index	1.5	1.3	4.1	2.0	-1.2	0.7	0.8	0.1
Intermittent access day 1 total infusions	1.4	1.6	5.1	2.3	-0.1	-0.9	-1.1	-0.8
Intermittent access day 15 total infusions	1.8	2.0	7.7	2.8	-1.2	0.4	-0.7	0.6
Intermittent access terminal intake (last 3 days)	1.1	1.2	4.1	2.0	-0.4	-0.4	-1.3	0.0
Intermittent access total infusions	1.1	1.3	3.7	1.9	-0.2	-0.7	-1.3	-0.5
Intermittent access day 1 locomotion	1.1	1.1	4.0	2.0	-0.0	-0.9	-0.5	-0.8
Intermittent access day 15 total locomotion	1.1	1.2	4.3	2.1	-1.0	0.4	-0.7	0.2
Intermittent access total locomotion	1.6	1.8	5.0	2.2	-0.2	-0.8	-1.6	-0.8
Intermittent access standard deviation	0.6	0.6	1.0	1.0	-0.9	0.7	-0.0	0.9
Left kidney weight	0.1	0.4	1.2	1.1	-0.6	0.2	-0.4	0.3
Right kidney weight	0.1	0.2	0.9	0.1	0.0	-0.2	-1.0	0.4
Cocaine induced anxiety	0.1	0.2	0.4	-0.4	0.4	-0.3	-0.6	0.1
Post-drug Anxiety	1.1	1.2	2.5	-1.6	1.3	-0.9	-1.0	0.0
Baseline Anxiety	0.7	0.7	2.3	-1.5	1.0	-0.6	0.1	-0.1
Tail length	0.5	1.5	2.9	-1.2	-0.3	1.1	1.5	1.7
Length with tail	0.6	2.1	7.7	-2.8	1.5	-0.6	0.1	0.6
Length without tail	1.0	2.2	5.1	-2.3	1.9	-1.3	-0.7	-0.3
Times rat made contact with spout	0.1	0.2	0.2	-0.5	-0.2	0.5	0.4	-0.4
Lifetime Intake	1.0	1.2	3.6	1.9	-0.1	-0.8	-1.1	-0.6
Liver weight, left	0.0	0.1	0.2	0.2	0.2	-0.4	-0.1	0.1
Liver weight, right	0.2	0.3	0.4	0.3	0.4	-0.6	0.6	0.6
Locomotor activity	3.4	5.4	6.6	2.3	-2.2	2.0	2.5	2.6
Locomotor testing distance	5.0	8.4	10.7	2.8	-2.7	2.5	3.3	3.1
Locomotor testing rearing	3.5	5.4	6.2	2.4	-2.3	2.0	2.5	2.3
Locomotion in novel chamber	1.1	1.4	4.5	2.1	-1.1	0.4	-0.5	0.8
Locomotion in novel chamber post-restriction	1.0	1.3	3.6	1.9	-1.3	0.8	0.2	0.6
Fecal boli incidents, locomotor time 1	1.1	1.2	2.9	-0.8	0.8	-1.0	-1.7	-0.8
Change in fecal boli incidents, locomotor task	0.3	0.3	1.1	0.4	0.2	-0.3	1.0	0.2
Time >=10cm from walls, locomotor time 1	2.7	2.7	4.9	0.1	1.5	-2.1	-2.2	-1.5
Bouts of movement, locomotor time 1	0.5	0.5	1.5	-1.2	-0.4	0.8	-0.2	-0.5
Total resting periods, locomotor time 1	0.4	0.5	1.2	-1.1	-0.2	0.5	-0.5	-0.7
Rest time, locomotor task time 1	0.7	0.8	1.4	1.2	-0.9	0.6	0.5	1.1
Distance moved, locomotor task time 1	0.5	0.5	1.0	-0.3	0.7	-0.8	-0.6	-1.0
Vertical activity count, locomotor time 1	0.8	0.8	1.8	1.4	-1.0	0.7	0.5	0.6
Time >=10cm from walls, locomotor time 2	0.5	0.5	1.3	-0.5	0.5	-0.5	-1.1	-0.7
Bouts of movement, locomotor time 2	0.2	0.2	0.4	-0.6	-0.3	0.6	-0.1	-0.6
Total resting periods, locomotor time 2	0.2	0.2	0.6	-0.4	-0.3	0.5	-0.2	-0.7
Rest time, locomotor task time 2	0.7	0.8	2.9	1.7	-0.8	0.2	0.2	0.4
Distance moved, locomotor task time 2	0.3	0.3	1.3	-1.1	0.5	-0.0	-0.1	-0.2
Vertical activity count, locomotor time 2	1.6	1.8	3.2	0.5	-1.0	1.3	1.7	1.8
Light reinforcement 1	0.4	0.7	1.3	0.6	-1.1	1.1	0.8	0.4
Light reinforcement 2	0.2	0.3	0.9	0.6	-0.2	-0.2	-1.0	-0.3
Bone: marrow area	1.1	2.5	5.6	0.8	1.4	-2.4	-1.6	-1.2
Bone: maximum diameter	1.1	2.0	3.0	-1.1	1.6	-1.7	-1.7	-0.6
Bone: maximum force	5.4	9.4	13.0	-3.0	3.6	-3.4	-2.8	-2.4
Bone: maximum moment	4.7	8.1	11.4	-2.8	3.4	-3.2	-2.6	-2.2
Mean time between licks in bursts	0.5	0.7	2.3	-0.3	-0.0	0.5	1.5	1.0
Mean num. licks in bursts	0.5	0.6	0.8	0.7	-0.9	0.9	0.9	0.5
Cd content in liver	0.5	0.5	1.0	0.9	-1.0	0.8	-0.1	0.5
Co content in liver	5.6	6.6	9.5	1.9	-2.9	3.1	2.7	2.0
Cu content in liver	0.1	0.2	0.4	-0.5	0.1	-0.0	-0.4	-0.6
Fe content in liver	0.3	0.4	0.6	-0.6	0.8	-0.7	-0.5	0.2
K content in liver	2.9	2.8	4.3	-1.4	2.1	-2.1	-1.2	-1.5
Mg content in liver	1.4	1.5	2.7	-0.3	1.1	-1.4	-1.1	-1.6
Mn content in liver	2.2	2.5	4.6	-2.1	1.8	-1.4	-1.5	-0.8
Na content in liver	0.9	0.9	1.9	-1.4	1.2	-0.9	-0.7	-0.1
Rb content in liver	0.5	0.7	2.4	1.5	-0.9	0.4	0.2	-0.2
Se content in liver	0.9	1.1	3.1	-0.5	0.8	-0.9	-1.8	-0.8
Sr content in liver	0.9	0.8	3.6	-1.9	0.6	0.2	-0.2	0.3
Zn content in liver	0.6	0.7	1.5	-1.2	0.8	-0.5	-0.7	-0.8
Bone: minimum diameter	1.1	2.1	3.4	0.7	1.0	-1.8	-1.7	-1.7
Time in familiar zone, hab. session 1	0.1	0.1	0.2	0.4	0.2	-0.5	-0.3	-0.4
Time in novel zone, hab. session 1	1.5	1.5	2.2	0.7	-1.1	1.2	1.5	1.4
Total zone transitions, hab. session 1	0.3	0.5	0.9	-0.9	0.7	-0.4	-0.5	-0.8
Total locomotion distance, hab. session 1	0.3	0.4	0.6	0.5	0.4	-0.7	-0.5	-0.8
Locomotion velocity, hab. session 1	0.3	0.4	0.8	0.0	0.5	-0.7	-0.6	-0.9
Time in familiar zone, hab. session 2	1.1	1.1	2.5	0.4	-0.4	0.6	1.5	1.6
Time in novel zone, hab. session 2	0.7	0.7	2.0	-0.4	0.3	-0.3	-1.0	-1.4
Total zone transitions, hab. session 2	2.2	2.9	3.9	-1.4	1.9	-1.8	-1.2	-2.0
Total locomotion distance, hab. session 2	0.9	1.2	2.4	0.0	1.1	-1.4	-0.7	-1.5
Locomotion velocity, hab. session 2	1.2	1.6	2.7	0.1	1.2	-1.6	-1.0	-1.6
Novel to familiar place preference ratio	2.1	2.1	3.6	-1.6	1.2	-1.1	-1.9	-1.4
Novelty place preference	1.3	1.3	2.6	-1.1	0.8	-0.7	-1.6	-1.3
Time in novel zone, NPP test	0.9	0.9	1.8	-0.9	0.7	-0.6	-1.4	-1.0
Total zone transitions, NPP test	1.9	2.8	4.0	-2.0	2.0	-1.6	-1.2	-1.4
Total locomotion distance, NPP test	0.5	0.7	1.2	-0.2	0.9	-1.0	-0.5	-1.1
Locomotion velocity, NPP test	0.5	0.7	1.5	-0.3	0.8	-0.9	-0.6	-1.2
Intraocular pressure	0.4	0.6	1.1	0.7	-1.1	0.8	-0.3	0.9
Delta distance traveled before/after self-admin	0.4	0.4	0.8	0.5	-0.6	0.6	0.9	0.6
Delta ambulatory time before/after self-admin	0.5	0.6	1.3	0.4	-0.7	0.7	1.1	0.7
Parametrial fat weight	0.6	1.1	3.0	1.7	-0.1	-1.0	-1.0	-0.6
Pavlov. Cond. lever latency	0.6	0.8	1.4	0.8	-1.1	1.2	0.8	0.3
Pavlov. Cond. magazine entry latency	0.8	1.0	1.5	-0.7	0.9	-1.0	-1.2	-1.1
Pavlov. Cond. change in total contacts	0.8	0.8	2.3	-0.6	0.6	-0.7	-1.5	-0.7
Pavlov. Cond. index score	0.2	0.3	0.6	-0.6	0.5	-0.5	-0.8	-0.0
Pavlov. Cond. latency score	0.2	0.3	0.5	-0.5	0.6	-0.6	-0.7	-0.1
Pavlov. Cond. lever contacts	0.1	0.1	0.3	-0.2	0.5	-0.6	-0.3	0.2
Pavlov. Cond. magazine entry number	0.2	0.3	0.8	0.8	-0.3	0.1	0.9	-0.0
Pavlov. Cond. intertrial magazine entries	0.6	0.8	1.3	0.8	-1.1	1.0	0.2	0.9
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	0.9	-0.9	0.8	-0.7	-1.0	-0.3
Pavlov. Cond. response bias	0.1	0.1	0.4	-0.5	0.2	-0.2	-0.6	0.2
Pavlov. Cond. lever latency	1.2	1.6	1.9	1.2	-1.4	1.3	1.4	1.0
Pavlov. Cond. magazine entry latency	2.6	3.0	5.2	-2.3	1.7	-1.3	-1.3	-1.8
Pavlov. Cond. change in total contacts	3.4	4.6	6.7	-2.2	1.8	-1.7	-2.6	-2.4
Pavlov. Cond. index score	3.1	4.0	5.0	-2.2	2.0	-1.7	-2.0	-1.9
Pavlov. Cond. latency score	3.0	3.7	4.1	-2.0	2.0	-1.8	-2.0	-1.8
Pavlov. Cond. lever contacts	0.6	0.8	1.2	-1.1	0.9	-0.8	-1.0	-0.6
Pavlov. Cond. magazine entry number	4.5	5.4	10.4	3.2	-2.3	1.6	2.0	2.2
Pavlov. Cond. intertrial magazine entries	0.4	0.5	1.5	1.2	-0.7	0.3	0.3	0.5
Pavlov. Cond. lever-magazine prob. diff.	3.2	4.1	5.8	-2.4	2.1	-1.7	-2.0	-2.0
Pavlov. Cond. response bias	1.8	2.4	3.9	-2.0	1.5	-1.2	-1.5	-1.4
Time in closed arm before self-admin	0.6	0.7	1.5	-0.6	0.7	-0.7	-1.2	-0.7
Time in closed arm after self-admin	0.1	0.1	0.2	0.4	0.1	-0.2	0.4	0.0
Time in open arm before self-admin	2.4	2.6	5.2	1.5	-1.6	1.5	2.3	1.0
Time in open arm after self-admin	1.1	1.2	2.0	0.6	-1.3	1.4	1.0	0.9
Bone: periosteal estimation	1.3	2.6	5.2	-0.5	1.8	-2.3	-1.9	-1.0
Bone: periosteal perimeter	1.2	2.0	3.4	-0.8	1.6	-1.8	-1.7	-0.8
Bone: post-yield work	10.6	14.5	19.8	-1.5	3.5	-4.3	-4.4	-4.5
Progressive ratio test 1 active lever presses	1.0	1.1	3.2	1.8	-1.2	0.7	0.0	0.6
Progressive ratio test 1 breakpoint	1.1	1.1	2.9	1.7	-1.2	0.8	0.2	0.7
Progressive ratio test 1 inactive lever presses	0.8	0.9	2.0	1.4	-1.2	0.9	0.5	0.3
Progressive ratio test 2 active lever presses	1.1	1.1	3.9	2.0	-1.0	0.4	-0.6	0.5
Progressive ratio test 2 breakpoint	2.0	2.2	6.0	2.4	-1.7	1.1	-0.0	1.1
Progressive ratio test 2 inactive lever presses	2.4	2.8	8.9	3.0	-1.8	1.0	-0.6	0.5
Incentive Sensitization - Responses	0.2	0.2	0.7	0.5	-0.1	-0.2	-0.8	-0.2
Incentive Sensitization - Breakpoint	0.2	0.2	0.6	0.7	-0.2	-0.1	-0.8	-0.1
Sum of active levers in priming session hrs 5-6	1.2	1.2	3.1	-1.8	0.9	-0.4	-1.3	0.3
Progressive ratio	5.2	6.0	7.5	-2.0	2.6	-2.7	-2.2	-2.6
Food seeking constrained by brief footshock	0.2	0.3	0.9	-0.1	-0.2	0.4	0.9	0.5
Seeking ratio, punishment vs. effort	5.6	6.8	8.0	2.1	-2.7	2.8	2.7	2.6
Retroperitoneal fat weight	1.4	4.7	17.9	4.2	-2.1	0.6	0.2	0.9
Reaction time number correct	0.1	0.2	0.4	-0.6	0.3	-0.1	0.4	0.6
Reaction time mean minus median	3.5	4.7	6.7	-2.6	2.2	-1.7	-2.2	-2.1
Reaction time mean minus median AUC	1.3	1.7	3.4	-1.8	1.3	-0.9	-1.2	-1.1
Reaction time num false alarms	1.3	1.8	3.7	1.2	-1.1	1.1	1.9	1.0
Reaction time num false alarms AUC	0.6	0.9	2.7	0.5	-0.6	0.8	1.6	0.5
Reaction time trials correct on left	0.1	0.2	0.4	-0.6	0.3	-0.1	0.4	0.6
Reaction time trials on left	0.2	0.2	0.5	-0.7	0.4	-0.1	0.4	0.6
Reaction time mean	0.3	0.4	1.0	-0.5	0.1	-0.0	-1.0	-0.9
Reaction time mean AUC	0.4	0.5	1.4	-0.4	0.2	-0.1	-1.2	-1.1
Median of all reaction times	0.2	0.2	0.6	0.1	-0.2	0.2	-0.8	-0.7
Reaction time omissions	0.5	0.7	1.7	-1.3	0.7	-0.4	-0.6	-0.9
Reaction time false alarm rate	0.7	0.9	2.0	1.0	-0.8	0.8	1.4	0.5
Reaction time premature initiation rate	0.6	0.8	2.0	-1.4	0.6	0.2	1.3	0.2
Reaction time premature initiations	0.9	1.3	3.7	-1.9	0.7	0.3	1.4	0.5
Std. dev. reaction times	1.0	1.4	2.0	-1.4	0.9	-0.6	-1.4	-1.3
Reaction time trials completed	0.2	0.2	0.5	-0.7	0.4	-0.1	0.4	0.6
Reaction time trials AUC	0.1	0.2	0.3	-0.5	0.3	-0.0	0.5	0.6
Run reversals in cocaine runway, females	1.0	0.9	1.9	-0.3	1.1	-1.2	0.1	-1.4
Run reversals in cocaine runway, males	1.4	1.4	3.2	0.6	-0.9	1.1	1.1	1.8
Latency to leave start box in cocaine runway	0.7	0.7	1.2	0.0	0.6	-1.1	-0.9	-1.1
Latency to leave start box in cocaine runway, F	0.3	0.3	0.9	-0.1	0.1	-0.3	-0.7	-1.0
Latency to leave start box in cocaine runway, M	0.5	0.4	1.4	0.0	0.8	-1.2	-0.4	-0.2
Std. dev. time between licks in bursts	1.3	1.5	3.4	0.7	-0.7	0.9	1.9	1.5
Total sessions with >9 infusions	0.5	0.6	2.3	1.5	0.0	-0.7	-0.1	-0.2
Short access day 1 total inactive lever presses	1.6	1.7	5.7	2.4	-1.4	0.8	0.4	0.5
Short access day 10 total inactive lever presses	3.4	3.8	6.6	2.6	-2.2	1.8	1.6	1.2
Short access day 1 total infusions	0.9	0.9	3.1	1.8	-0.2	-0.6	-0.6	-0.8
Short access day 10 total infusions	1.8	2.0	2.8	1.1	0.9	-1.7	-1.5	-1.7
Short access total infusions	0.7	0.8	1.4	1.2	0.5	-1.1	-0.7	-0.9
Short access day 1 locomotion	0.6	0.7	2.8	1.7	-0.2	-0.5	-0.3	-0.5
Short access day 10 total locomotion	0.5	0.6	1.9	1.4	-0.1	-0.5	-0.5	-0.8
Short access total locomotion	0.5	0.5	1.7	1.3	0.0	-0.6	-0.3	-0.7
One hour access (0.3 mA shock)	3.3	3.9	11.5	3.4	-2.1	1.2	0.1	1.4
Compulsive drug intake	0.9	0.9	2.6	-1.1	-0.2	0.8	1.6	0.4
One hour access (shock baseline)	2.1	2.4	7.8	2.8	-1.4	0.6	-1.1	0.8
Social response proportion	0.8	0.8	1.5	-1.2	1.0	-0.7	-0.8	-0.7
Social responses	0.1	0.1	0.3	-0.5	0.1	0.1	0.3	0.5
Social time	0.2	0.2	0.4	-0.6	0.2	0.0	0.5	0.6
Soleus weight	1.7	4.8	13.3	3.6	-2.3	1.2	1.1	1.6
Bone: stiffness	4.7	7.4	9.0	-2.6	3.0	-2.8	-2.7	-2.5
Tibialis anterior weight	5.1	17.4	43.9	-6.6	5.1	-3.3	-2.0	-1.5
Time to tail flick, vehicle, before self-admin	1.4	1.4	2.0	-1.0	1.4	-1.3	-1.1	-1.1
Time to tail flick, vehicle, after self-admin	1.5	1.6	2.8	-1.2	1.7	-1.5	-0.3	-1.1
Time to tail flick, test, before self-admin	0.4	0.4	0.9	0.9	0.3	-0.8	-0.0	-0.7
Time to tail flick, test, after self-admin	0.0	0.0	0.1	-0.1	-0.0	0.1	0.2	0.3
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.4	-0.5	0.6	-0.6	0.2	-0.5
Delta time to tail flick, test, before/after SA	0.8	0.8	1.4	-1.2	-0.4	1.0	0.4	1.1
Tibia length	1.4	4.0	6.3	-2.5	2.1	-1.7	-2.4	-0.6
Ambulatory time before self-admin	1.3	1.3	2.6	-1.1	1.1	-1.0	-1.6	-0.9
Ambulatory time after self-admin	0.4	0.4	1.3	-0.1	0.2	-0.4	-1.1	-0.8
Bone: tissue strength	0.3	0.3	0.7	-0.3	0.4	-0.4	-0.7	-0.8
Total heroin consumption	2.7	3.1	8.0	-2.8	1.9	-1.1	-1.0	-1.4
Bone: trabecular number	2.0	3.1	4.2	-1.2	1.8	-1.9	-2.1	-1.7
Bone: trabecular spacing	0.9	1.1	2.0	0.9	-1.1	1.1	1.4	0.6
Bone: trabecular thickness	0.2	0.3	0.5	0.7	-0.0	-0.4	-0.7	-0.6
Bone: trabecular tissue density	1.7	2.4	5.0	2.2	-1.9	1.3	0.7	1.1
Water consumed over 24 hours	0.3	0.4	0.8	-0.8	-0.4	0.9	0.5	0.3
Number of responses in last shaping day	1.7	1.8	2.3	1.5	-1.5	1.2	1.2	1.2