Sac3d1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Sac3d1	0.2	0.09	0.0e+00	0.16	0.16	0.15	0.15	4.0e-17	3.0e-17	7.2e-16	2.2e-16
2	PL	gene expression	Sac3d1	0.06	0.03	8.4e-05	0.03	0.04	0.04	0.04	3.9e-04	1.8e-05	7.0e-05	4.1e-05
3	IC	gene expression	Sac3d1	0.14	0.08	2.3e-04	0.06	0.05	0.06	0.05	1.0e-03	4.6e-03	1.3e-03	3.0e-03
4	Brain	mRNA stability	Sac3d1	0.04	0.03	8.8e-03	0	0.02	0.01	0.01	3.3e-01	5.9e-03	3.1e-02	8.7e-02
5	Brain	gene expression	Sac3d1	0.17	0.1	1.5e-05	0.06	0.05	0.05	0.05	5.1e-06	1.0e-05	2.2e-05	2.8e-05
6	NAcc	gene expression	Sac3d1	0.47	0.11	0.0e+00	0.31	0.3	0.32	0.31	1.3e-48	7.1e-47	1.2e-49	2.9e-48

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	1.9	3.2	4.0	-1.1	2.0	2.0	-1.6	2.0	1.9
Area under the delay curve	0.0	0.1	0.3	0.2	0.5	-0.0	-0.1	-0.1	0.1
BMI with tail	5.8	20.1	25.7	-2.8	4.9	5.1	-3.6	5.0	4.9
BMI without tail	1.4	4.2	6.2	-1.4	2.5	2.3	-1.3	2.2	2.2
Body weight	3.0	13.0	16.5	-3.9	3.7	4.0	-2.0	4.1	3.6
Weight adjusted by age	0.4	0.7	2.6	-1.6	0.6	0.6	-0.3	0.6	0.5
Bone surface	6.2	11.2	13.6	-3.7	3.4	3.5	-2.8	3.4	3.3
Bone volume	4.1	7.4	8.1	-2.4	2.9	2.8	-2.7	2.8	2.8
Breakpoint value in progressive ratio session	1.7	2.0	5.2	-2.3	1.5	1.1	-1.0	1.1	0.9
Number of licking bursts	0.2	0.3	0.5	-0.7	0.5	0.4	-0.5	0.5	0.4
Context. condit. distance diff. score	0.7	0.9	2.9	1.7	-0.8	-0.7	0.5	-0.7	-0.7
Locomotion velocity, session 1	0.3	0.3	1.0	0.2	-0.6	-0.3	1.0	-0.3	-0.5
Locomotion distance, session 1	0.9	1.1	1.5	-0.6	1.2	1.2	-0.5	1.2	1.2
Locomotion velocity, session 2	2.2	2.5	3.6	-1.9	1.7	1.7	-0.8	1.7	1.5
Locomotion distance, session 2	0.5	0.8	1.2	-0.8	1.1	1.0	-0.3	0.9	0.9
Locomotion velocity, session 3	0.9	1.0	1.7	0.4	0.8	1.3	-0.5	1.3	1.3
Locomotion distance, session 3	0.0	0.0	0.0	0.2	-0.1	0.1	0.1	0.1	0.0
Stereotopy head waving bouts, day 3	0.8	0.9	1.6	0.9	0.5	1.1	-0.3	1.2	1.3
Stereotopy head waving duration, day 3	0.3	0.4	0.7	0.8	0.2	0.6	-0.4	0.7	0.8
Locomotion velocity, session 7	1.2	1.3	2.1	0.5	1.1	1.2	-1.1	1.2	1.5
Locomotion distance, session 7	0.1	0.2	0.4	0.4	0.4	0.5	0.1	0.5	0.6
Stereotopy head waving bouts, day 7	0.9	1.0	1.9	-0.2	1.0	1.0	-1.4	1.0	1.0
Stereotopy head waving duration, day 7	1.6	1.9	2.5	-1.2	1.6	1.2	-1.6	1.3	1.2
Locomotion velocity, session 8	0.2	0.3	0.9	-0.8	-0.2	0.1	1.0	0.1	-0.1
Locomotion distance, session 8	0.5	0.7	1.1	0.4	0.7	1.0	-0.6	1.0	1.0
Degree of sensitization distance	0.7	0.7	1.4	0.0	0.7	1.0	-0.4	1.0	1.2
Degree of sensitization stereotypy	1.3	1.4	2.4	-1.0	1.3	1.0	-1.5	1.1	1.0
Conditioned locomotion	0.6	0.7	1.9	-1.4	0.7	0.9	-0.1	0.9	0.7
Cocaine response after cond. corrected	0.7	0.9	2.6	1.6	-1.0	-0.6	1.0	-0.4	-0.5
Cocaine response after cond. not corrected	0.4	0.5	1.7	1.3	-0.8	-0.3	0.8	-0.2	-0.2
Cocaine response before conditioning	0.5	0.6	1.5	-1.2	0.8	0.5	-0.8	0.6	0.5
Saline control response	1.2	1.6	5.6	-2.4	1.0	1.0	0.1	1.1	0.9
Bone: connectivity density	3.3	5.2	6.2	-2.3	2.5	2.4	-1.7	2.4	2.3
Bone: cortical apparent density	0.7	0.9	1.7	-0.0	-0.6	-1.2	0.6	-1.2	-1.3
Bone: cortical area	0.7	1.1	1.9	-1.4	0.9	1.1	-0.8	1.0	1.0
Bone: cortical porosity	0.2	0.2	0.4	-0.4	0.6	0.5	-0.4	0.5	0.4
Bone: cortical porosity	0.5	0.5	0.7	-0.8	0.8	0.8	-0.4	0.8	0.6
Bone: cortical thickness	0.6	1.0	3.7	-1.9	-0.2	-0.5	1.1	-0.5	-0.8
Bone: cortical thickness	1.1	1.3	2.9	-0.2	-1.0	-1.1	1.7	-1.1	-1.3
Bone: cortical tissue density	0.7	1.0	1.8	-0.2	-0.6	-1.2	0.7	-1.3	-1.3
Condit. Reinf. active minus inactive responses	0.0	0.1	0.2	-0.3	0.4	0.1	-0.1	0.0	0.2
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.6	0.0	-0.1	-0.7	0.2	-0.7	-0.6
Condit. Reinf. active responses	0.4	0.5	0.6	-0.2	0.8	0.7	-0.7	0.6	0.8
Condit. Reinf. inactive responses	1.3	1.5	2.4	0.0	1.0	1.5	-1.2	1.4	1.5
Incentive salience index mean	0.6	0.7	1.2	-0.6	1.1	0.9	-0.7	0.8	0.9
Condit. Reinf. lever presses	1.6	2.2	2.9	-1.1	1.5	1.7	-1.3	1.6	1.6
Condit. Reinf. active minus inactive responses	0.2	0.3	0.9	-0.0	0.4	0.4	-0.9	0.4	0.5
Condit. Reinf. active-inactive response ratio	1.2	1.4	2.7	0.3	0.8	1.3	-1.6	1.2	1.4
Condit. Reinf. active responses	0.2	0.3	0.7	-0.5	0.7	0.3	-0.8	0.4	0.3
Condit. Reinf. inactive responses	0.1	0.2	0.3	-0.5	0.3	-0.5	0.3	-0.3	-0.5
Condit. Reinf. lever presses	2.1	2.9	4.3	-2.1	1.7	1.6	-1.7	1.6	1.5
Condit. Reinf. lever reinforcers received	0.3	0.4	0.7	-0.8	0.7	0.3	-0.8	0.4	0.3
Conditioned reinforcement - actives	0.4	0.7	1.7	-0.7	0.4	0.7	-1.3	0.6	0.8
Conditioned reinforcement - inactives	0.5	0.8	2.2	1.5	-0.8	-0.8	-0.8	-0.7	-0.5
Conditioned locomotion	2.9	3.7	9.5	3.1	-2.0	-1.9	0.1	-1.9	-1.5
Patch foraging indifference point 0 sec	0.0	0.0	0.0	0.2	0.1	-0.1	-0.1	-0.0	0.1
Patch foraging indifference point AUC	0.8	1.1	4.6	-2.1	0.9	0.6	-0.8	0.4	0.4
Delay disc. indifference point, 0s delay	0.1	0.1	0.3	0.5	0.6	0.2	-0.2	0.1	0.4
Delay disc. indifference point, 16s delay	0.2	0.2	0.7	0.8	0.2	-0.4	-0.5	-0.3	-0.2
Delay disc. indifference point, 2s delay	0.2	0.2	0.4	0.1	0.5	0.5	-0.6	0.4	0.6
Delay disc. indifference point, 24s delay	0.7	0.7	1.0	0.4	-0.7	-1.0	1.0	-1.0	-0.9
Delay disc. indifference point, 4s delay	0.1	0.1	0.2	0.4	0.2	-0.1	0.4	-0.4	-0.0
Delay disc. indifference point, 8s delay	0.1	0.1	0.2	0.3	0.0	-0.3	0.5	-0.2	-0.3
Indifference point function ln k	3.1	5.4	16.2	4.0	-2.3	-1.8	1.8	-1.7	-1.4
Indifference point function log k	3.1	5.4	16.2	4.0	-2.3	-1.8	1.8	-1.7	-1.4
Patch foraging total patch changes 0 sec	0.1	0.2	0.3	0.2	-0.4	-0.5	0.5	-0.4	-0.4
Patch foraging total patch changes 12 sec	1.6	2.1	6.7	-2.6	1.6	1.0	-0.8	1.0	0.8
Patch foraging total patch changes 18 sec	0.6	0.9	1.4	-1.2	1.1	0.8	-0.9	0.7	0.8
Patch foraging total patch changes 24 sec	0.3	0.6	3.2	-1.8	0.3	0.2	0.1	0.1	0.1
Patch foraging total patch changes 6 sec	0.3	0.4	1.3	-1.1	0.7	0.6	0.0	0.4	0.5
Patch foraging time to switch 0 sec	3.5	7.1	8.9	-2.1	3.0	2.8	-2.5	2.9	2.7
Patch foraging water rate 0 sec	3.8	7.9	10.8	3.0	-3.3	-2.8	2.3	-2.9	-2.6
Patch foraging water rate 12 sec	7.3	15.3	19.6	4.4	-4.4	-3.7	3.5	-3.8	-3.6
Patch foraging water rate 18 sec	2.4	3.7	6.4	2.5	-2.3	-1.5	2.0	-1.6	-1.5
Patch foraging water rate 24 sec	3.6	5.0	7.8	2.8	-2.7	-1.9	2.0	-2.0	-1.8
Patch foraging water rate 6 sec	5.6	8.2	11.1	3.2	-3.3	-2.5	3.0	-2.7	-2.5
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.4	0.6	0.3	-0.1	-0.3	0.2	0.0
Distance traveled before self-admin	1.4	1.8	2.5	-1.3	1.5	1.2	-1.6	1.2	1.2
Distance traveled after self-admin	0.1	0.1	0.3	-0.6	0.2	-0.2	-0.3	-0.4	-0.4
Extensor digitorum longus weight	3.8	15.0	34.8	-5.9	3.8	3.7	-1.6	3.8	3.1
Bone: elastic displacement	3.3	3.8	5.1	1.5	-2.2	-1.9	2.3	-1.8	-1.9
Bone: elastic work	0.5	0.7	2.4	-0.6	-0.6	-0.5	1.5	-0.4	-0.8
Bone: endosteal estimation	1.9	4.1	6.7	0.6	1.6	2.4	-1.9	2.3	2.6
Bone: endosteal perimeter	2.4	5.1	7.9	0.6	1.7	2.6	-2.5	2.5	2.8
Epididymis fat weight	0.5	1.6	7.5	2.7	-0.8	0.1	-1.0	0.1	0.5
Delta time in closed arm before/after self-admin	0.5	0.5	2.2	0.1	-0.5	-0.3	1.5	-0.3	-0.4
Delta time in open arm before/after self-admin	0.5	0.5	1.4	-0.9	0.6	0.4	-1.2	0.2	0.2
Diff in mean of infusions in LGA sessions	0.1	0.2	0.7	-0.9	0.1	0.2	0.2	0.3	0.0
Delay discount exponential model param	0.0	0.0	0.2	-0.1	-0.4	0.1	0.0	0.2	0.0
Extinction: sum of active levers before priming	2.3	2.6	3.5	-1.9	1.9	1.5	-1.2	1.5	1.5
Active lever presses in extinction session 6	3.2	3.2	6.3	-2.5	1.6	1.8	-1.4	1.6	1.6
Bone: final force	2.2	3.5	5.7	-2.4	1.8	2.0	-1.2	1.9	1.8
Bone: final moment	2.0	3.2	5.3	-2.3	1.7	1.9	-1.1	1.8	1.7
Food consumed during 24 hour testing period	0.1	0.2	0.3	-0.3	-0.5	-0.6	0.1	-0.5	-0.5
Glucose	0.7	1.1	3.7	1.9	0.4	0.8	-0.7	0.9	1.0
Heart weight	0.8	1.3	1.8	1.2	0.8	1.3	-0.3	1.4	1.4
Delay discount hyperbolic model param	0.0	0.1	0.3	-0.1	-0.5	-0.0	0.2	0.0	-0.2
Intermittent access intake day 1-15 change	0.2	0.5	0.9	0.9	-0.7	-0.7	-0.4	-0.7	-0.5
Intermittent access intake escalation	0.2	0.4	0.5	0.7	-0.7	-0.6	-0.5	-0.7	-0.4
Intermittent access intake escalation 2	0.3	0.4	0.5	0.7	-0.6	-0.7	-0.5	-0.7	-0.5
Intermitt. access day 1 inactive lever presses	0.1	0.3	0.6	0.5	-0.4	-0.8	0.1	-0.6	-0.8
Intermitt. access day 15 inactive lever presses	0.2	0.5	1.4	1.2	-0.1	-0.1	-1.1	0.2	0.1
Intermitt. access escalation Index	1.1	1.6	5.0	2.2	-0.9	-1.2	0.5	-1.2	-0.9
Intermittent access day 1 total infusions	1.7	2.7	4.7	1.3	1.2	1.6	-2.2	1.5	1.9
Intermittent access day 15 total infusions	0.8	1.2	4.0	2.0	-0.2	0.2	-1.7	0.1	0.7
Intermittent access terminal intake (last 3 days)	1.4	1.8	4.8	1.6	0.5	1.0	-2.2	0.8	1.4
Intermittent access total infusions	1.8	2.1	4.3	1.4	0.8	1.3	-2.1	1.1	1.7
Intermittent access day 1 locomotion	0.9	1.2	2.3	1.2	0.7	0.9	-1.5	0.8	1.2
Intermittent access day 15 total locomotion	0.7	1.3	4.4	1.6	0.3	0.3	-2.1	0.3	0.7
Intermittent access total locomotion	2.2	2.6	7.6	1.9	0.8	1.0	-2.7	0.9	1.5
Intermittent access standard deviation	0.3	0.5	1.4	1.2	-0.9	-0.6	-0.0	-0.6	-0.6
Left kidney weight	0.1	0.6	1.5	1.2	0.4	0.6	-1.1	0.4	0.8
Right kidney weight	0.0	0.2	0.8	0.9	-0.3	0.1	-0.3	-0.1	0.2
Cocaine induced anxiety	0.1	0.2	0.4	-0.4	0.4	0.2	-0.7	0.3	0.3
Post-drug Anxiety	0.6	0.6	1.1	-1.1	0.7	0.7	-0.6	0.9	0.7
Baseline Anxiety	0.2	0.2	0.9	-0.3	-0.3	-0.2	0.9	-0.0	-0.2
Tail length	0.3	1.3	2.6	-0.9	-0.8	-1.0	1.6	-1.0	-1.2
Length with tail	0.4	1.6	7.6	-2.8	0.5	0.6	0.9	0.7	0.2
Length without tail	0.4	1.3	5.5	-2.4	0.2	0.6	1.1	0.7	0.2
Times rat made contact with spout	0.2	0.2	0.3	-0.5	0.1	-0.5	0.4	-0.3	-0.6
Lifetime Intake	1.3	1.6	2.7	1.3	0.7	1.2	-1.6	1.0	1.5
Liver weight, left	0.3	0.5	1.6	1.3	-0.9	-0.2	0.8	-0.2	-0.2
Liver weight, right	1.0	1.7	4.9	2.2	-1.5	-0.7	1.5	-0.6	-0.6
Locomotor activity	3.0	4.7	6.2	2.3	-2.5	-1.9	2.3	-2.0	-1.9
Locomotor testing distance	3.6	6.5	8.5	2.6	-2.9	-2.3	2.8	-2.3	-2.3
Locomotor testing rearing	2.6	5.2	6.1	2.5	-2.5	-2.1	2.4	-2.1	-2.2
Locomotion in novel chamber	1.0	1.2	5.8	2.4	-1.0	-0.5	-0.3	-0.5	-0.1
Locomotion in novel chamber post-restriction	0.6	1.0	3.7	1.9	-0.8	-0.8	-0.4	-0.8	-0.5
Fecal boli incidents, locomotor time 1	0.6	0.8	2.0	-0.6	0.8	0.7	-1.4	1.0	0.7
Change in fecal boli incidents, locomotor task	0.1	0.1	0.5	0.4	-0.1	0.2	0.7	-0.1	0.2
Time >=10cm from walls, locomotor time 1	3.6	3.8	6.3	0.1	1.8	2.0	-2.5	1.9	2.3
Bouts of movement, locomotor time 1	0.6	0.7	1.4	-1.2	0.0	-0.9	0.0	-0.7	-1.1
Total resting periods, locomotor time 1	0.4	0.4	1.0	-1.0	0.2	-0.6	-0.3	-0.4	-0.8
Rest time, locomotor task time 1	0.4	0.5	1.4	1.2	-0.8	-0.5	0.1	-0.5	-0.4
Distance moved, locomotor task time 1	0.4	0.6	1.0	-0.4	1.0	0.8	-0.6	0.8	0.9
Vertical activity count, locomotor time 1	0.2	0.5	1.4	1.2	-0.6	-0.6	0.4	-0.6	-0.5
Time >=10cm from walls, locomotor time 2	0.3	0.5	1.4	-0.6	0.7	0.5	-1.2	0.4	0.5
Bouts of movement, locomotor time 2	0.1	0.2	0.4	-0.6	0.3	-0.5	-0.1	-0.4	-0.7
Total resting periods, locomotor time 2	0.1	0.1	0.3	-0.4	0.3	-0.3	-0.3	-0.3	-0.5
Rest time, locomotor task time 2	0.4	0.5	2.7	1.7	-0.5	-0.1	-0.1	-0.4	-0.2
Distance moved, locomotor task time 2	0.2	0.2	1.3	-1.1	0.2	-0.1	0.2	-0.1	-0.1
Vertical activity count, locomotor time 2	1.3	1.8	2.9	0.4	-1.5	-1.4	1.7	-1.4	-1.3
Light reinforcement 1	0.3	0.7	1.0	0.4	-0.8	-1.0	0.7	-1.0	-0.9
Light reinforcement 2	0.2	0.3	1.1	0.5	-0.0	0.3	-1.0	0.3	0.5
Bone: marrow area	1.8	4.0	6.7	0.7	1.5	2.4	-1.9	2.3	2.6
Bone: maximum diameter	1.2	2.2	3.0	-1.2	1.1	1.7	-1.5	1.6	1.7
Bone: maximum force	5.1	9.0	10.3	-3.0	3.1	3.2	-2.4	3.2	3.1
Bone: maximum moment	4.7	8.3	9.6	-2.9	2.9	3.1	-2.3	3.0	3.0
Mean time between licks in bursts	0.3	0.6	2.3	-0.1	-0.6	-0.5	1.5	-0.5	-0.7
Mean num. licks in bursts	0.4	0.7	0.8	0.7	-0.7	-0.9	0.8	-0.9	-0.9
Cd content in liver	0.2	0.3	0.8	0.8	-0.1	-0.3	-0.9	-0.3	-0.1
Co content in liver	6.0	6.9	8.5	1.8	-2.6	-2.9	2.5	-2.9	-2.9
Cu content in liver	0.1	0.1	0.1	0.2	0.4	-0.2	-0.4	-0.2	-0.2
Fe content in liver	0.2	0.2	0.3	-0.5	-0.0	0.5	0.2	0.6	0.5
K content in liver	0.9	0.9	1.4	-0.7	1.0	1.1	-0.3	1.2	1.0
Mg content in liver	0.1	0.1	0.6	0.8	-0.1	-0.1	0.3	0.0	0.0
Mn content in liver	2.2	2.5	5.4	-2.3	1.4	1.5	-1.1	1.4	1.4
Na content in liver	0.1	0.1	0.6	-0.8	-0.2	0.1	0.3	0.1	-0.1
Rb content in liver	1.2	1.5	3.8	1.9	-1.0	-1.1	0.9	-1.0	-0.9
Se content in liver	0.2	0.2	0.8	0.0	0.3	0.3	-0.9	0.3	0.4
Sr content in liver	0.6	0.5	3.0	-1.7	0.3	0.0	0.0	-0.0	-0.2
Zn content in liver	0.1	0.1	0.2	-0.5	0.3	-0.2	0.1	-0.1	-0.2
Bone: minimum diameter	1.6	2.9	4.1	0.6	1.6	1.8	-1.9	1.8	2.0
Time in familiar zone, hab. session 1	0.2	0.2	0.3	0.5	0.3	0.4	-0.4	0.4	0.5
Time in novel zone, hab. session 1	1.4	1.4	2.2	0.7	-1.3	-1.1	1.5	-1.1	-1.2
Total zone transitions, hab. session 1	0.2	0.3	0.8	-0.9	0.8	0.4	-0.5	0.3	0.3
Total locomotion distance, hab. session 1	0.3	0.4	0.7	0.5	0.6	0.7	-0.7	0.7	0.8
Locomotion velocity, hab. session 1	0.3	0.4	0.5	0.0	0.7	0.7	-0.7	0.7	0.7
Time in familiar zone, hab. session 2	0.7	0.8	2.3	0.3	-1.0	-0.6	1.5	-0.6	-0.7
Time in novel zone, hab. session 2	0.4	0.4	1.0	-0.3	0.8	0.4	-1.0	0.4	0.4
Total zone transitions, hab. session 2	2.4	3.1	4.5	-1.3	2.1	1.9	-1.3	1.9	1.8
Total locomotion distance, hab. session 2	1.1	1.4	2.0	-0.0	1.3	1.4	-0.9	1.4	1.4
Locomotion velocity, hab. session 2	1.4	1.9	2.7	0.1	1.5	1.6	-1.2	1.6	1.6
Novel to familiar place preference ratio	1.7	1.8	3.0	-1.5	1.5	1.0	-1.7	1.1	1.1
Novelty place preference	1.0	1.1	2.3	-1.1	1.2	0.7	-1.5	0.7	0.7
Time in novel zone, NPP test	0.7	0.8	1.6	-0.9	1.0	0.6	-1.3	0.6	0.6
Total zone transitions, NPP test	1.8	2.6	3.9	-2.0	1.8	1.6	-1.1	1.6	1.4
Total locomotion distance, NPP test	0.5	0.6	0.9	-0.2	1.0	0.9	-0.6	0.9	0.9
Locomotion velocity, NPP test	0.4	0.6	1.0	-0.3	1.0	0.8	-0.7	0.8	0.8
Intraocular pressure	0.5	0.7	1.1	0.8	-1.0	-0.9	-0.2	-0.9	-1.0
Delta distance traveled before/after self-admin	2.0	2.1	2.8	0.9	-1.4	-1.4	1.7	-1.6	-1.6
Delta ambulatory time before/after self-admin	1.4	1.7	2.7	0.6	-1.3	-1.3	1.6	-1.4	-1.4
Parametrial fat weight	0.6	1.4	6.0	2.5	-0.0	0.3	-1.2	0.3	0.6
Pavlov. Cond. lever latency	0.6	0.7	0.9	0.7	-1.0	-0.9	0.7	-0.9	-0.9
Pavlov. Cond. magazine entry latency	1.1	1.4	2.4	-0.8	1.5	1.1	-1.4	1.1	1.2
Pavlov. Cond. change in total contacts	1.0	1.0	2.5	-0.6	1.3	0.7	-1.6	0.7	0.8
Pavlov. Cond. index score	0.4	0.4	0.7	-0.7	0.8	0.5	-0.8	0.5	0.5
Pavlov. Cond. latency score	0.4	0.5	0.8	-0.6	0.9	0.7	-0.8	0.6	0.7
Pavlov. Cond. lever contacts	0.5	0.5	0.7	-0.4	0.9	0.8	-0.6	0.8	0.8
Pavlov. Cond. magazine entry number	0.2	0.3	0.7	0.8	-0.6	-0.1	0.8	-0.1	-0.1
Pavlov. Cond. intertrial magazine entries	0.6	0.7	1.0	0.8	-0.8	-1.0	0.2	-1.0	-1.0
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.8	1.3	-0.9	1.1	0.8	-1.1	0.7	0.7
Pavlov. Cond. response bias	0.2	0.2	0.5	-0.7	0.6	0.3	-0.7	0.2	0.2
Pavlov. Cond. lever latency	0.9	1.3	1.7	1.3	-1.0	-1.1	1.1	-1.1	-1.1
Pavlov. Cond. magazine entry latency	2.6	3.2	7.0	-2.6	2.1	1.5	-1.4	1.5	1.3
Pavlov. Cond. change in total contacts	2.2	3.5	5.2	-2.1	2.1	1.6	-2.3	1.5	1.5
Pavlov. Cond. index score	2.7	3.6	5.4	-2.3	2.0	1.7	-1.9	1.7	1.6
Pavlov. Cond. latency score	2.7	3.6	4.8	-2.2	2.0	1.8	-1.9	1.8	1.7
Pavlov. Cond. lever contacts	0.9	1.2	1.7	-1.3	1.0	1.0	-1.1	1.1	1.0
Pavlov. Cond. magazine entry number	3.9	4.8	11.7	3.4	-2.4	-1.7	1.8	-1.7	-1.5
Pavlov. Cond. intertrial magazine entries	0.3	0.4	1.4	1.2	-0.7	-0.4	0.2	-0.4	-0.3
Pavlov. Cond. lever-magazine prob. diff.	2.9	3.8	6.3	-2.5	2.1	1.7	-1.9	1.7	1.6
Pavlov. Cond. response bias	2.0	2.7	4.6	-2.1	1.7	1.5	-1.5	1.5	1.4
Time in closed arm before self-admin	0.4	0.6	1.6	0.2	0.6	0.6	-1.3	0.6	0.8
Time in closed arm after self-admin	0.1	0.2	0.6	0.8	-0.3	-0.1	0.4	-0.2	0.0
Time in open arm before self-admin	2.6	2.9	6.1	1.2	-1.5	-1.6	2.5	-1.4	-1.6
Time in open arm after self-admin	0.4	0.4	0.7	-0.1	-0.5	-0.7	0.8	-0.7	-0.9
Bone: periosteal estimation	1.8	3.7	5.7	-0.6	1.6	2.3	-1.9	2.2	2.4
Bone: periosteal perimeter	1.7	3.0	4.1	-0.9	1.5	2.0	-1.7	2.0	2.0
Bone: post-yield work	11.4	16.6	20.5	-1.6	4.4	4.3	-4.5	4.3	4.5
Progressive ratio test 1 active lever presses	0.2	0.2	0.7	0.2	0.2	0.5	-0.9	0.3	0.5
Progressive ratio test 1 breakpoint	0.2	0.3	0.8	0.1	0.3	0.6	-0.9	0.4	0.6
Progressive ratio test 1 inactive lever presses	0.0	0.1	0.1	0.2	-0.1	-0.3	-0.4	-0.2	-0.3
Progressive ratio test 2 active lever presses	0.5	0.6	1.9	1.1	-0.0	0.3	-1.4	0.1	0.5
Progressive ratio test 2 breakpoint	0.5	0.5	1.7	1.1	-0.1	0.2	-1.3	0.0	0.5
Progressive ratio test 2 inactive lever presses	1.1	1.8	7.5	2.7	-0.8	-0.8	-1.3	-0.8	-0.2
Incentive Sensitization - Responses	0.8	1.1	1.8	-0.3	1.0	1.1	-1.3	1.1	1.2
Incentive Sensitization - Breakpoint	0.7	0.9	1.7	-0.1	0.9	1.0	-1.3	0.9	1.1
Sum of active levers in priming session hrs 5-6	0.6	0.6	2.6	-1.6	-0.0	0.2	-0.8	0.2	0.1
Progressive ratio	4.1	6.4	8.0	-1.5	2.7	2.8	-2.3	2.8	2.7
Food seeking constrained by brief footshock	0.0	0.1	0.2	-0.0	-0.2	-0.2	0.5	-0.1	-0.1
Seeking ratio, punishment vs. effort	4.7	6.7	7.6	2.0	-2.7	-2.8	2.7	-2.7	-2.7
Retroperitoneal fat weight	2.4	10.4	43.0	6.6	-3.1	-2.0	0.9	-1.9	-1.3
Reaction time number correct	0.1	0.1	0.4	-0.6	-0.3	0.1	0.5	-0.0	0.0
Reaction time mean minus median	1.7	4.3	7.4	-2.7	2.1	1.8	-1.9	2.0	1.7
Reaction time mean minus median AUC	0.6	1.5	3.7	-1.9	1.1	1.0	-1.0	1.2	0.9
Reaction time num false alarms	1.4	1.9	3.4	1.3	-1.4	-1.3	1.8	-1.2	-1.2
Reaction time num false alarms AUC	0.7	1.1	2.7	0.7	-0.9	-1.0	1.6	-0.9	-0.9
Reaction time trials correct on left	0.1	0.1	0.4	-0.6	-0.3	0.1	0.5	-0.0	0.0
Reaction time trials on left	0.1	0.1	0.5	-0.7	-0.3	0.1	0.5	-0.0	0.1
Reaction time mean	0.2	0.3	0.9	-0.4	0.6	0.2	-1.0	0.5	0.1
Reaction time mean AUC	0.3	0.4	1.3	-0.4	0.7	0.3	-1.2	0.6	0.3
Median of all reaction times	0.1	0.1	0.6	0.2	0.2	-0.1	-0.7	0.2	-0.1
Reaction time omissions	0.8	1.2	2.7	-1.7	1.1	0.8	-0.8	1.1	0.7
Reaction time false alarm rate	0.7	0.9	1.6	1.1	-0.8	-0.9	1.3	-0.7	-0.8
Reaction time premature initiation rate	0.5	0.7	2.2	-1.4	-0.1	-0.0	1.5	-0.1	-0.4
Reaction time premature initiations	0.7	1.2	3.7	-1.9	-0.3	-0.2	1.7	-0.3	-0.6
Std. dev. reaction times	0.7	1.2	2.2	-1.5	1.2	0.8	-1.2	1.1	0.7
Reaction time trials completed	0.1	0.1	0.5	-0.7	-0.3	0.1	0.5	-0.0	0.1
Reaction time trials AUC	0.1	0.1	0.3	-0.5	-0.4	0.0	0.6	-0.1	0.0
Run reversals in cocaine runway, females	0.8	0.8	1.3	-0.2	1.0	1.1	0.0	1.1	1.1
Run reversals in cocaine runway, males	1.3	1.3	2.2	0.6	-1.5	-1.1	1.2	-1.2	-1.2
Latency to leave start box in cocaine runway	0.9	1.1	1.4	0.1	1.1	1.2	-1.1	1.1	1.2
Latency to leave start box in cocaine runway, F	0.2	0.2	0.5	0.1	0.7	0.4	-0.7	0.3	0.3
Latency to leave start box in cocaine runway, M	1.5	1.4	2.4	-0.2	0.8	1.5	-0.7	1.6	1.5
Std. dev. time between licks in bursts	0.9	1.2	3.1	0.6	-1.2	-0.8	1.8	-0.9	-0.9
Total sessions with >9 infusions	1.2	1.5	2.2	-0.2	1.2	1.5	-1.2	1.3	1.5
Short access day 1 total inactive lever presses	0.6	0.7	3.6	1.9	-0.7	-0.3	0.1	-0.4	-0.2
Short access day 10 total inactive lever presses	0.4	1.0	1.4	1.2	-0.9	-1.0	0.9	-0.9	-1.0
Short access day 1 total infusions	0.6	0.8	1.6	1.2	0.5	0.8	-0.9	0.6	1.0
Short access day 10 total infusions	3.0	3.8	5.5	0.3	1.9	2.2	-2.3	2.0	2.3
Short access total infusions	1.6	2.1	3.6	0.5	1.2	1.8	-1.4	1.5	1.9
Short access day 1 locomotion	0.3	0.4	1.6	1.3	0.1	0.2	-0.6	-0.0	0.5
Short access day 10 total locomotion	0.5	1.0	2.4	0.7	0.8	0.8	-1.5	0.8	1.0
Short access total locomotion	0.6	0.8	1.7	1.0	0.6	0.7	-1.3	0.6	0.9
One hour access (0.3 mA shock)	1.3	1.5	6.7	2.6	-1.0	-0.6	-0.4	-0.7	-0.3
Compulsive drug intake	1.8	2.1	6.0	-0.7	-1.1	-1.2	2.4	-1.0	-1.6
One hour access (shock baseline)	1.0	1.5	5.9	2.4	-0.4	-0.1	-1.6	-0.2	0.4
Social response proportion	0.4	0.5	1.1	-1.1	0.7	0.7	-0.6	0.7	0.4
Social responses	0.1	0.1	0.2	-0.5	-0.2	-0.0	0.4	-0.1	-0.3
Social time	0.1	0.2	0.4	-0.6	-0.3	-0.2	0.6	-0.1	-0.2
Soleus weight	1.4	4.0	13.8	3.7	-2.0	-1.5	0.8	-1.3	-1.2
Bone: stiffness	4.0	6.5	7.2	-2.6	2.7	2.6	-2.3	2.5	2.5
Tibialis anterior weight	3.7	12.4	41.5	-6.4	2.9	2.9	-0.9	3.1	2.4
Time to tail flick, vehicle, before self-admin	1.1	1.1	1.6	-0.7	1.1	1.1	-1.0	1.2	1.3
Time to tail flick, vehicle, after self-admin	2.1	2.7	3.8	-1.0	1.9	1.9	-1.0	1.9	2.0
Time to tail flick, test, before self-admin	0.5	0.5	2.5	1.6	0.2	0.3	-0.3	0.2	0.6
Time to tail flick, test, after self-admin	0.2	0.2	0.3	-0.5	0.3	0.4	-0.5	0.4	0.4
Delta time to tail flick, vehicle, before/after SA	0.5	0.5	0.7	-0.6	0.8	0.8	-0.2	0.8	0.7
Delta time to tail flick, test, before/after SA	0.8	0.9	2.6	-1.6	-0.7	-0.7	0.4	-0.7	-1.0
Tibia length	1.1	3.1	6.0	-2.4	1.4	1.6	-1.9	1.5	1.4
Ambulatory time before self-admin	1.4	2.0	3.5	-1.2	1.6	1.3	-1.9	1.2	1.3
Ambulatory time after self-admin	0.1	0.2	0.6	0.3	0.3	-0.2	-0.8	-0.3	-0.2
Bone: tissue strength	0.1	0.1	0.2	-0.1	0.3	0.2	-0.5	0.3	0.3
Total heroin consumption	1.9	2.2	7.6	-2.8	1.5	1.0	-0.7	1.2	0.8
Bone: trabecular number	2.3	3.8	4.6	-1.5	2.2	2.0	-2.0	2.0	2.0
Bone: trabecular spacing	1.2	1.6	1.9	1.2	-1.2	-1.3	1.4	-1.3	-1.3
Bone: trabecular thickness	0.3	0.3	0.6	0.6	0.5	0.5	-0.8	0.5	0.5
Bone: trabecular tissue density	1.7	2.5	6.1	2.5	-1.7	-1.4	0.5	-1.4	-1.3
Water consumed over 24 hours	0.4	0.5	0.9	-1.0	-0.1	-0.7	0.6	-0.7	-0.9
Number of responses in last shaping day	0.4	0.4	0.7	0.3	-0.7	-0.6	0.8	-0.7	-0.7