Hub : Genes

Sac3d1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Sac3d1 0.2 0.09 0.0e+00 0.16 0.16 0.15 0.15 4.0e-17 3.0e-17 7.2e-16 2.3e-16
2 PL gene expression Sac3d1 0.06 0.03 8.4e-05 0.03 0.04 0.04 0.04 3.9e-04 1.8e-05 7.0e-05 4.2e-05
3 IC gene expression Sac3d1 0.14 0.08 2.3e-04 0.06 0.05 0.06 0.05 1.0e-03 4.6e-03 1.3e-03 3.0e-03
4 Brain mRNA stability Sac3d1 0.04 0.03 8.8e-03 0 0.02 0.01 0.01 3.3e-01 5.9e-03 3.1e-02 8.3e-02
5 Brain gene expression Sac3d1 0.17 0.1 1.5e-05 0.06 0.05 0.05 0.05 5.1e-06 1.0e-05 2.2e-05 3.1e-05
6 NAcc gene expression Sac3d1 0.47 0.11 0.0e+00 0.31 0.3 0.32 0.31 1.3e-48 7.1e-47 1.2e-49 2.6e-48

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bone: apparent density1.73.24.0-1.12.0-2.0-1.6-2.0-1.9
Area under the delay curve0.00.10.30.20.50.0-0.10.1-0.1
BMI with tail5.720.125.7-2.84.9-5.1-3.6-5.0-4.9
BMI without tail0.84.26.2-1.42.5-2.3-1.3-2.2-2.2
Body weight3.013.016.5-3.93.7-4.0-2.0-4.1-3.6
Weight adjusted by age0.20.72.6-1.60.6-0.6-0.3-0.6-0.5
Bone surface5.711.213.6-3.73.4-3.5-2.8-3.4-3.3
Bone volume3.77.48.1-2.42.9-2.8-2.7-2.8-2.8
Breakpoint value in progressive ratio session1.12.05.2-2.31.5-1.1-1.0-1.1-0.9
Number of licking bursts0.10.30.5-0.70.5-0.4-0.5-0.5-0.4
Context. condit. distance diff. score0.70.92.91.7-0.80.70.50.70.7
Locomotion velocity, session 10.30.31.00.2-0.60.31.00.30.5
Locomotion distance, session 10.81.11.5-0.61.2-1.2-0.5-1.2-1.2
Locomotion velocity, session 22.12.53.6-1.91.7-1.7-0.8-1.7-1.5
Locomotion distance, session 20.50.81.2-0.81.1-1.0-0.3-0.9-0.9
Locomotion velocity, session 30.91.01.70.40.8-1.3-0.5-1.3-1.3
Locomotion distance, session 30.00.00.00.2-0.1-0.10.1-0.1-0.0
Stereotopy head waving bouts, day 30.70.91.60.90.5-1.1-0.3-1.2-1.3
Stereotopy head waving duration, day 30.30.40.70.80.2-0.6-0.4-0.7-0.8
Locomotion velocity, session 71.21.32.10.51.1-1.2-1.1-1.2-1.5
Locomotion distance, session 70.10.20.40.40.4-0.50.1-0.5-0.6
Stereotopy head waving bouts, day 70.91.01.9-0.21.0-1.0-1.4-1.0-1.0
Stereotopy head waving duration, day 71.51.92.5-1.21.6-1.2-1.6-1.3-1.2
Locomotion velocity, session 80.20.30.9-0.8-0.2-0.11.0-0.10.1
Locomotion distance, session 80.50.71.10.40.7-1.0-0.6-1.0-1.0
Degree of sensitization distance0.70.71.40.00.7-1.0-0.4-1.0-1.2
Degree of sensitization stereotypy1.31.42.4-1.01.3-1.0-1.5-1.1-1.0
Conditioned locomotion0.60.71.9-1.40.7-0.9-0.1-0.9-0.7
Cocaine response after cond. corrected0.60.92.61.6-1.00.61.00.40.5
Cocaine response after cond. not corrected0.40.51.71.3-0.80.30.80.20.2
Cocaine response before conditioning0.50.61.5-1.20.8-0.5-0.8-0.6-0.5
Saline control response1.21.65.6-2.41.0-1.00.1-1.1-0.9
Bone: connectivity density3.25.26.2-2.32.5-2.4-1.7-2.4-2.3
Bone: cortical apparent density0.60.91.7-0.0-0.61.20.61.21.3
Bone: cortical area0.71.11.9-1.40.9-1.1-0.8-1.0-1.0
Bone: cortical porosity0.20.20.4-0.40.6-0.5-0.4-0.5-0.4
Bone: cortical porosity0.50.50.7-0.80.8-0.8-0.4-0.8-0.6
Bone: cortical thickness0.61.03.7-1.9-0.20.51.10.50.8
Bone: cortical thickness1.11.32.9-0.2-1.01.11.71.11.3
Bone: cortical tissue density0.61.01.8-0.2-0.61.20.71.31.3
Condit. Reinf. active minus inactive responses0.00.10.2-0.30.4-0.1-0.1-0.0-0.2
Condit. Reinf. active-inactive response ratio0.20.20.60.0-0.10.70.20.70.6
Condit. Reinf. active responses0.40.50.6-0.20.8-0.7-0.7-0.6-0.8
Condit. Reinf. inactive responses1.21.52.40.01.0-1.5-1.2-1.4-1.5
Incentive salience index mean0.60.71.2-0.61.1-0.9-0.7-0.8-0.9
Condit. Reinf. lever presses1.52.22.9-1.11.5-1.7-1.3-1.6-1.6
Condit. Reinf. active minus inactive responses0.20.30.9-0.00.4-0.4-0.9-0.4-0.5
Condit. Reinf. active-inactive response ratio0.91.42.70.30.8-1.3-1.6-1.2-1.4
Condit. Reinf. active responses0.20.30.7-0.50.7-0.3-0.8-0.4-0.3
Condit. Reinf. inactive responses0.10.20.3-0.50.30.50.30.30.5
Condit. Reinf. lever presses2.02.94.3-2.11.7-1.6-1.7-1.6-1.5
Condit. Reinf. lever reinforcers received0.30.40.7-0.80.7-0.3-0.8-0.4-0.3
Conditioned reinforcement - actives0.20.71.7-0.70.4-0.7-1.3-0.6-0.8
Conditioned reinforcement - inactives0.30.82.21.5-0.80.8-0.80.70.5
Conditioned locomotion2.53.79.53.1-2.01.90.11.91.5
Patch foraging indifference point 0 sec0.00.00.00.20.10.1-0.10.0-0.1
Patch foraging indifference point AUC0.51.14.6-2.10.9-0.6-0.8-0.4-0.4
Delay disc. indifference point, 0s delay0.10.10.30.50.6-0.2-0.2-0.1-0.4
Delay disc. indifference point, 16s delay0.20.20.70.80.20.4-0.50.30.2
Delay disc. indifference point, 2s delay0.20.20.40.10.5-0.5-0.6-0.4-0.6
Delay disc. indifference point, 24s delay0.50.71.00.4-0.71.01.01.00.9
Delay disc. indifference point, 4s delay0.10.10.20.40.20.10.40.40.0
Delay disc. indifference point, 8s delay0.10.10.20.30.00.30.50.20.3
Indifference point function ln k1.85.416.24.0-2.31.81.81.71.4
Indifference point function log k1.85.416.24.0-2.31.81.81.71.4
Patch foraging total patch changes 0 sec0.10.20.30.2-0.40.50.50.40.4
Patch foraging total patch changes 12 sec1.52.16.7-2.61.6-1.0-0.8-1.0-0.8
Patch foraging total patch changes 18 sec0.40.91.4-1.21.1-0.8-0.9-0.7-0.8
Patch foraging total patch changes 24 sec0.20.63.2-1.80.3-0.20.1-0.1-0.1
Patch foraging total patch changes 6 sec0.20.41.3-1.10.7-0.60.0-0.4-0.5
Patch foraging time to switch 0 sec1.97.18.9-2.13.0-2.8-2.5-2.9-2.7
Patch foraging water rate 0 sec2.17.910.83.0-3.32.82.32.92.6
Patch foraging water rate 12 sec3.815.319.64.4-4.43.73.53.83.6
Patch foraging water rate 18 sec1.73.76.42.5-2.31.52.01.61.5
Patch foraging water rate 24 sec3.55.07.82.8-2.71.92.02.01.8
Patch foraging water rate 6 sec5.58.211.13.2-3.32.53.02.72.5
Seeking ratio, delayed vs. immediate footshock0.10.10.40.60.30.1-0.3-0.2-0.0
Distance traveled before self-admin0.81.82.5-1.31.5-1.2-1.6-1.2-1.2
Distance traveled after self-admin0.10.10.3-0.60.20.2-0.30.40.4
Extensor digitorum longus weight3.815.034.8-5.93.8-3.7-1.6-3.8-3.1
Bone: elastic displacement3.03.85.11.5-2.21.92.31.81.9
Bone: elastic work0.50.72.4-0.6-0.60.51.50.40.8
Bone: endosteal estimation1.74.16.70.61.6-2.4-1.9-2.3-2.6
Bone: endosteal perimeter2.15.17.90.61.7-2.6-2.5-2.5-2.8
Epididymis fat weight0.31.67.52.7-0.8-0.1-1.0-0.1-0.5
Delta time in closed arm before/after self-admin0.50.52.20.1-0.50.31.50.30.4
Delta time in open arm before/after self-admin0.40.51.4-0.90.6-0.4-1.2-0.2-0.2
Diff in mean of infusions in LGA sessions0.10.20.7-0.90.1-0.20.2-0.3-0.0
Delay discount exponential model param0.00.00.2-0.1-0.4-0.10.0-0.2-0.0
Extinction: sum of active levers before priming1.72.63.5-1.91.9-1.5-1.2-1.5-1.5
Active lever presses in extinction session 63.23.26.3-2.51.6-1.8-1.4-1.6-1.6
Bone: final force2.13.55.7-2.41.8-2.0-1.2-1.9-1.8
Bone: final moment2.03.25.3-2.31.7-1.9-1.1-1.8-1.7
Food consumed during 24 hour testing period0.10.20.3-0.3-0.50.60.10.50.5
Glucose0.71.13.71.90.4-0.8-0.7-0.9-1.0
Heart weight0.81.31.81.20.8-1.3-0.3-1.4-1.4
Delay discount hyperbolic model param0.00.10.3-0.1-0.50.00.2-0.00.2
Intermittent access intake day 1-15 change0.10.50.90.9-0.70.7-0.40.70.5
Intermittent access intake escalation0.10.40.50.7-0.70.6-0.50.70.4
Intermittent access intake escalation 20.20.40.50.7-0.60.7-0.50.70.5
Intermitt. access day 1 inactive lever presses0.00.30.60.5-0.40.80.10.60.8
Intermitt. access day 15 inactive lever presses0.10.51.41.2-0.10.1-1.1-0.2-0.1
Intermitt. access escalation Index0.51.65.02.2-0.91.20.51.20.9
Intermittent access day 1 total infusions0.92.74.71.31.2-1.6-2.2-1.5-1.9
Intermittent access day 15 total infusions0.51.24.02.0-0.2-0.2-1.7-0.1-0.7
Intermittent access terminal intake (last 3 days)1.01.84.81.60.5-1.0-2.2-0.8-1.4
Intermittent access total infusions1.82.14.31.40.8-1.3-2.1-1.1-1.7
Intermittent access day 1 locomotion0.71.22.31.20.7-0.9-1.5-0.8-1.2
Intermittent access day 15 total locomotion0.31.34.41.60.3-0.3-2.1-0.3-0.7
Intermittent access total locomotion2.22.67.61.90.8-1.0-2.7-0.9-1.5
Intermittent access standard deviation0.10.51.41.2-0.90.6-0.00.60.6
Left kidney weight0.10.61.51.20.4-0.6-1.1-0.4-0.8
Right kidney weight0.00.20.80.9-0.3-0.1-0.30.1-0.2
Cocaine induced anxiety0.10.20.4-0.40.4-0.2-0.7-0.3-0.3
Post-drug Anxiety0.50.61.1-1.10.7-0.7-0.6-0.9-0.7
Baseline Anxiety0.10.20.9-0.3-0.30.20.90.00.2
Tail length0.21.32.6-0.9-0.81.01.61.01.2
Length with tail0.41.67.6-2.80.5-0.60.9-0.7-0.2
Length without tail0.21.35.5-2.40.2-0.61.1-0.7-0.2
Times rat made contact with spout0.20.20.3-0.50.10.50.40.30.6
Lifetime Intake1.31.62.71.30.7-1.2-1.6-1.0-1.5
Liver weight, left0.30.51.61.3-0.90.20.80.20.2
Liver weight, right1.01.74.92.2-1.50.71.50.60.6
Locomotor activity3.04.76.22.3-2.51.92.32.01.9
Locomotor testing distance2.66.58.52.6-2.92.32.82.32.3
Locomotor testing rearing1.45.26.12.5-2.52.12.42.12.2
Locomotion in novel chamber0.91.25.82.4-1.00.5-0.30.50.1
Locomotion in novel chamber post-restriction0.31.03.71.9-0.80.8-0.40.80.5
Fecal boli incidents, locomotor time 10.30.82.0-0.60.8-0.7-1.4-1.0-0.7
Change in fecal boli incidents, locomotor task0.10.10.50.4-0.1-0.20.70.1-0.2
Time >=10cm from walls, locomotor time 13.03.86.30.11.8-2.0-2.5-1.9-2.3
Bouts of movement, locomotor time 10.50.71.4-1.20.00.90.00.71.1
Total resting periods, locomotor time 10.30.41.0-1.00.20.6-0.30.40.8
Rest time, locomotor task time 10.30.51.41.2-0.80.50.10.50.4
Distance moved, locomotor task time 10.20.61.0-0.41.0-0.8-0.6-0.8-0.9
Vertical activity count, locomotor time 10.10.51.41.2-0.60.60.40.60.5
Time >=10cm from walls, locomotor time 20.20.51.4-0.60.7-0.5-1.2-0.4-0.5
Bouts of movement, locomotor time 20.10.20.4-0.60.30.5-0.10.40.7
Total resting periods, locomotor time 20.00.10.3-0.40.30.3-0.30.30.5
Rest time, locomotor task time 20.30.52.71.7-0.50.1-0.10.40.2
Distance moved, locomotor task time 20.20.21.3-1.10.20.10.20.10.1
Vertical activity count, locomotor time 20.81.82.90.4-1.51.41.71.41.3
Light reinforcement 10.20.71.00.4-0.81.00.71.00.9
Light reinforcement 20.10.31.10.5-0.0-0.3-1.0-0.3-0.5
Bone: marrow area1.64.06.70.71.5-2.4-1.9-2.3-2.6
Bone: maximum diameter1.12.23.0-1.21.1-1.7-1.5-1.6-1.7
Bone: maximum force4.69.010.3-3.03.1-3.2-2.4-3.2-3.1
Bone: maximum moment4.48.39.6-2.92.9-3.1-2.3-3.0-3.0
Mean time between licks in bursts0.10.62.3-0.1-0.60.51.50.50.7
Mean num. licks in bursts0.20.70.80.7-0.70.90.80.90.9
Cd content in liver0.20.30.80.8-0.10.3-0.90.30.1
Co content in liver5.96.98.51.8-2.62.92.52.92.9
Cu content in liver0.10.10.10.20.40.2-0.40.20.2
Fe content in liver0.20.20.3-0.5-0.0-0.50.2-0.6-0.5
K content in liver0.90.91.4-0.71.0-1.1-0.3-1.2-1.0
Mg content in liver0.10.10.60.8-0.10.10.3-0.0-0.0
Mn content in liver2.22.55.4-2.31.4-1.5-1.1-1.4-1.4
Na content in liver0.10.10.6-0.8-0.2-0.10.3-0.10.1
Rb content in liver1.21.53.81.9-1.01.10.91.00.9
Se content in liver0.20.20.80.00.3-0.3-0.9-0.3-0.4
Sr content in liver0.60.53.0-1.70.3-0.00.00.00.2
Zn content in liver0.10.10.2-0.50.30.20.10.10.2
Bone: minimum diameter1.52.94.10.61.6-1.8-1.9-1.8-2.0
Time in familiar zone, hab. session 10.20.20.30.50.3-0.4-0.4-0.4-0.5
Time in novel zone, hab. session 11.21.42.20.7-1.31.11.51.11.2
Total zone transitions, hab. session 10.20.30.8-0.90.8-0.4-0.5-0.3-0.3
Total locomotion distance, hab. session 10.30.40.70.50.6-0.7-0.7-0.7-0.8
Locomotion velocity, hab. session 10.30.40.50.00.7-0.7-0.7-0.7-0.7
Time in familiar zone, hab. session 20.70.82.30.3-1.00.61.50.60.7
Time in novel zone, hab. session 20.30.41.0-0.30.8-0.4-1.0-0.4-0.4
Total zone transitions, hab. session 22.43.14.5-1.32.1-1.9-1.3-1.9-1.8
Total locomotion distance, hab. session 21.11.42.0-0.01.3-1.4-0.9-1.4-1.4
Locomotion velocity, hab. session 21.41.92.70.11.5-1.6-1.2-1.6-1.6
Novel to familiar place preference ratio1.41.83.0-1.51.5-1.0-1.7-1.1-1.1
Novelty place preference0.81.12.3-1.11.2-0.7-1.5-0.7-0.7
Time in novel zone, NPP test0.60.81.6-0.91.0-0.6-1.3-0.6-0.6
Total zone transitions, NPP test1.72.63.9-2.01.8-1.6-1.1-1.6-1.4
Total locomotion distance, NPP test0.50.60.9-0.21.0-0.9-0.6-0.9-0.9
Locomotion velocity, NPP test0.40.61.0-0.31.0-0.8-0.7-0.8-0.8
Intraocular pressure0.40.71.10.8-1.00.9-0.20.91.0
Delta distance traveled before/after self-admin1.92.12.80.9-1.41.41.71.61.6
Delta ambulatory time before/after self-admin1.01.72.70.6-1.31.31.61.41.4
Parametrial fat weight0.61.46.02.5-0.0-0.3-1.2-0.3-0.6
Pavlov. Cond. lever latency0.60.70.90.7-1.00.90.70.90.9
Pavlov. Cond. magazine entry latency1.11.42.4-0.81.5-1.1-1.4-1.1-1.2
Pavlov. Cond. change in total contacts0.91.02.5-0.61.3-0.7-1.6-0.7-0.8
Pavlov. Cond. index score0.40.40.7-0.70.8-0.5-0.8-0.5-0.5
Pavlov. Cond. latency score0.40.50.8-0.60.9-0.7-0.8-0.6-0.7
Pavlov. Cond. lever contacts0.40.50.7-0.40.9-0.8-0.6-0.8-0.8
Pavlov. Cond. magazine entry number0.20.30.70.8-0.60.10.80.10.1
Pavlov. Cond. intertrial magazine entries0.60.71.00.8-0.81.00.21.01.0
Pavlov. Cond. lever-magazine prob. diff.0.70.81.3-0.91.1-0.8-1.1-0.7-0.7
Pavlov. Cond. response bias0.20.20.5-0.70.6-0.3-0.7-0.2-0.2
Pavlov. Cond. lever latency0.91.31.71.3-1.01.11.11.11.1
Pavlov. Cond. magazine entry latency2.33.27.0-2.62.1-1.5-1.4-1.5-1.3
Pavlov. Cond. change in total contacts1.43.55.2-2.12.1-1.6-2.3-1.5-1.5
Pavlov. Cond. index score2.33.65.4-2.32.0-1.7-1.9-1.7-1.6
Pavlov. Cond. latency score2.33.64.8-2.22.0-1.8-1.9-1.8-1.7
Pavlov. Cond. lever contacts0.81.21.7-1.31.0-1.0-1.1-1.1-1.0
Pavlov. Cond. magazine entry number3.74.811.73.4-2.41.71.81.71.5
Pavlov. Cond. intertrial magazine entries0.20.41.41.2-0.70.40.20.40.3
Pavlov. Cond. lever-magazine prob. diff.2.53.86.3-2.52.1-1.7-1.9-1.7-1.6
Pavlov. Cond. response bias2.02.74.6-2.11.7-1.5-1.5-1.5-1.4
Time in closed arm before self-admin0.30.61.60.20.6-0.6-1.3-0.6-0.8
Time in closed arm after self-admin0.10.20.60.8-0.30.10.40.2-0.0
Time in open arm before self-admin2.32.96.11.2-1.51.62.51.41.6
Time in open arm after self-admin0.40.40.7-0.1-0.50.70.80.70.9
Bone: periosteal estimation1.63.75.7-0.61.6-2.3-1.9-2.2-2.4
Bone: periosteal perimeter1.53.04.1-0.91.5-2.0-1.7-2.0-2.0
Bone: post-yield work9.616.620.5-1.64.4-4.3-4.5-4.3-4.5
Progressive ratio test 1 active lever presses0.10.20.70.20.2-0.5-0.9-0.3-0.5
Progressive ratio test 1 breakpoint0.20.30.80.10.3-0.6-0.9-0.4-0.6
Progressive ratio test 1 inactive lever presses0.00.10.10.2-0.10.3-0.40.20.3
Progressive ratio test 2 active lever presses0.40.61.91.1-0.0-0.3-1.4-0.1-0.5
Progressive ratio test 2 breakpoint0.40.51.71.1-0.1-0.2-1.3-0.0-0.5
Progressive ratio test 2 inactive lever presses0.61.87.52.7-0.80.8-1.30.80.2
Incentive Sensitization - Responses0.41.11.8-0.31.0-1.1-1.3-1.1-1.2
Incentive Sensitization - Breakpoint0.40.91.7-0.10.9-1.0-1.3-0.9-1.1
Sum of active levers in priming session hrs 5-60.60.62.6-1.6-0.0-0.2-0.8-0.2-0.1
Progressive ratio2.26.48.0-1.52.7-2.8-2.3-2.8-2.7
Food seeking constrained by brief footshock0.00.10.2-0.0-0.20.20.50.10.1
Seeking ratio, punishment vs. effort3.06.77.62.0-2.72.82.72.72.7
Retroperitoneal fat weight2.310.443.06.6-3.12.00.91.91.3
Reaction time number correct0.00.10.4-0.6-0.3-0.10.50.0-0.0
Reaction time mean minus median0.74.37.4-2.72.1-1.8-1.9-2.0-1.7
Reaction time mean minus median AUC0.21.53.7-1.91.1-1.0-1.0-1.2-0.9
Reaction time num false alarms1.11.93.41.3-1.41.31.81.21.2
Reaction time num false alarms AUC0.51.12.70.7-0.91.01.60.90.9
Reaction time trials correct on left0.00.10.4-0.6-0.3-0.10.50.0-0.0
Reaction time trials on left0.00.10.5-0.7-0.3-0.10.50.0-0.1
Reaction time mean0.10.30.9-0.40.6-0.2-1.0-0.5-0.1
Reaction time mean AUC0.20.41.3-0.40.7-0.3-1.2-0.6-0.3
Median of all reaction times0.10.10.60.20.20.1-0.7-0.20.1
Reaction time omissions0.71.22.7-1.71.1-0.8-0.8-1.1-0.7
Reaction time false alarm rate0.70.91.61.1-0.80.91.30.70.8
Reaction time premature initiation rate0.50.72.2-1.4-0.10.01.50.10.4
Reaction time premature initiations0.41.23.7-1.9-0.30.21.70.30.6
Std. dev. reaction times0.41.22.2-1.51.2-0.8-1.2-1.1-0.7
Reaction time trials completed0.00.10.5-0.7-0.3-0.10.50.0-0.1
Reaction time trials AUC0.00.10.3-0.5-0.4-0.00.60.1-0.0
Run reversals in cocaine runway, females0.70.81.3-0.21.0-1.10.0-1.1-1.1
Run reversals in cocaine runway, males1.21.32.20.6-1.51.11.21.21.2
Latency to leave start box in cocaine runway0.81.11.40.11.1-1.2-1.1-1.1-1.2
Latency to leave start box in cocaine runway, F0.20.20.50.10.7-0.4-0.7-0.3-0.3
Latency to leave start box in cocaine runway, M1.41.42.4-0.20.8-1.5-0.7-1.6-1.5
Std. dev. time between licks in bursts0.61.23.10.6-1.20.81.80.90.9
Total sessions with >9 infusions1.21.52.2-0.21.2-1.5-1.2-1.3-1.5
Short access day 1 total inactive lever presses0.40.73.61.9-0.70.30.10.40.2
Short access day 10 total inactive lever presses0.11.01.41.2-0.91.00.90.91.0
Short access day 1 total infusions0.40.81.61.20.5-0.8-0.9-0.6-1.0
Short access day 10 total infusions2.33.85.50.31.9-2.2-2.3-2.0-2.3
Short access total infusions1.52.13.60.51.2-1.8-1.4-1.5-1.9
Short access day 1 locomotion0.20.41.61.30.1-0.2-0.60.0-0.5
Short access day 10 total locomotion0.21.02.40.70.8-0.8-1.5-0.8-1.0
Short access total locomotion0.50.81.71.00.6-0.7-1.3-0.6-0.9
One hour access (0.3 mA shock)1.31.56.72.6-1.00.6-0.40.70.3
Compulsive drug intake1.42.16.0-0.7-1.11.22.41.01.6
One hour access (shock baseline)0.61.55.92.4-0.40.1-1.60.2-0.4
Social response proportion0.40.51.1-1.10.7-0.7-0.6-0.7-0.4
Social responses0.10.10.2-0.5-0.20.00.40.10.3
Social time0.10.20.4-0.6-0.30.20.60.10.2
Soleus weight1.44.013.83.7-2.01.50.81.31.2
Bone: stiffness3.66.57.2-2.62.7-2.6-2.3-2.5-2.5
Tibialis anterior weight3.612.441.5-6.42.9-2.9-0.9-3.1-2.4
Time to tail flick, vehicle, before self-admin0.91.11.6-0.71.1-1.1-1.0-1.2-1.3
Time to tail flick, vehicle, after self-admin1.32.73.8-1.01.9-1.9-1.0-1.9-2.0
Time to tail flick, test, before self-admin0.40.52.51.60.2-0.3-0.3-0.2-0.6
Time to tail flick, test, after self-admin0.20.20.3-0.50.3-0.4-0.5-0.4-0.4
Delta time to tail flick, vehicle, before/after SA0.40.50.7-0.60.8-0.8-0.2-0.8-0.7
Delta time to tail flick, test, before/after SA0.70.92.6-1.6-0.70.70.40.71.0
Tibia length1.13.16.0-2.41.4-1.6-1.9-1.5-1.4
Ambulatory time before self-admin0.72.03.5-1.21.6-1.3-1.9-1.2-1.3
Ambulatory time after self-admin0.10.20.60.30.30.2-0.80.30.2
Bone: tissue strength0.10.10.2-0.10.3-0.2-0.5-0.3-0.3
Total heroin consumption1.92.27.6-2.81.5-1.0-0.7-1.2-0.8
Bone: trabecular number2.03.84.6-1.52.2-2.0-2.0-2.0-2.0
Bone: trabecular spacing1.11.61.91.2-1.21.31.41.31.3
Bone: trabecular thickness0.20.30.60.60.5-0.5-0.8-0.5-0.5
Bone: trabecular tissue density1.42.56.12.5-1.71.40.51.41.3
Water consumed over 24 hours0.30.50.9-1.0-0.10.70.60.70.9
Number of responses in last shaping day0.30.40.70.3-0.70.60.80.70.7