Hub : Traits : TA weight in grams : ← →

chr5:48,482,122-49,968,409

Best TWAS P=5.409705e-08 · Best GWAS P=2.331361e-08 conditioned to 1

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Slc35a1	gene expression	ENSRNOG00000008908	0.11	0.05	top1	1	0.05	1.1e-06	5.3	5.3	8.9e-08	0.83	0.07	0.92	FALSE
2	Adipose	RGD1359108	gene expression	ENSRNOG00000009478	0.13	0.06	top1	1	0.06	1.9e-07	5.3	-5.3	1.1e-07	-0.86	0.26	0.71	FALSE
3	Adipose	Rars2	intron excision ratio	chr5:49210334:49211494	0.03	0.02	top1	1	0.02	1.2e-03	5.2	5.2	1.8e-07	0.80	0.05	0.07	TRUE
4	BLA	RGD1359108	gene expression	ENSRNOG00000009478	0.08	0.05	top1	1	0.05	9.6e-04	5.2	-5.2	2.3e-07	-0.54	0.04	0.04	FALSE
5	BLA	RGD1359108	mRNA stability	ENSRNOG00000009478	0.11	0.06	lasso	22	0.07	1.8e-04	5.3	5.3	1.1e-07	-0.87	0.27	0.70	TRUE
6	Brain	Rars2	intron excision ratio	chr5:49195892:49196811	0.03	0.01	blup	1563	0.02	4.7e-03	4.9	-5.2	1.8e-07	-0.85	0.42	0.39	TRUE
7	Brain	Slc35a1	mRNA stability	ENSRNOG00000008908	0.08	0.05	blup	1548	0.06	2.5e-06	4.8	5.2	2.6e-07	0.88	0.51	0.49	FALSE
8	Brain	RGD1359108	mRNA stability	ENSRNOG00000009478	0.16	0.11	blup	1015	0.12	3.0e-11	5.3	5.2	1.6e-07	0.98	0.26	0.74	FALSE
9	IL	Rars2	isoform ratio	ENSRNOT00000011688	0.16	0.07	enet	3	0.15	1.7e-04	4.9	-5.1	3.1e-07	-0.87	0.41	0.36	FALSE
10	IL	Rars2	isoform ratio	ENSRNOT00000115962	0.15	0.07	enet	4	0.13	4.5e-04	4.9	5.1	2.8e-07	0.87	0.39	0.35	FALSE
11	Liver	Slc35a1	isoform ratio	ENSRNOT00000081150	0.04	0.00	blup	1548	0.01	1.8e-02	4.9	-5.2	1.8e-07	-0.87	0.35	0.37	FALSE
12	Liver	Rars2	intron excision ratio	chr5:49222641:49232932	0.03	0.01	enet	18	0.01	4.3e-02	5.4	5.4	5.5e-08	0.89	0.40	0.39	FALSE
13	NAcc2	Rars2	intron excision ratio	chr5:49210334:49211494	0.06	0.03	blup	1563	0.03	9.4e-03	5.2	5.2	2.0e-07	0.87	0.41	0.38	FALSE
14	NAcc2	RGD1359108	mRNA stability	ENSRNOG00000009478	0.13	0.05	top1	1	0.05	8.9e-04	5.3	5.3	1.2e-07	0.98	0.05	0.07	FALSE
15	OFC	RGD1359108	gene expression	ENSRNOG00000009478	0.29	0.08	top1	1	0.08	5.7e-03	5.4	5.4	7.7e-08	0.61	0.05	0.06	TRUE
16	PL2	Rars2	alternative polyA	ENSRNOT00000011688	0.08	0.06	top1	1	0.06	3.9e-04	5.2	-5.2	1.8e-07	-0.88	0.07	0.12	FALSE
17	PL2	Rars2	alternative polyA	ENSRNOT00000115962	0.08	0.06	top1	1	0.06	2.8e-04	5.2	5.2	1.8e-07	0.88	0.07	0.13	FALSE
18	PL2	RGD1359108	mRNA stability	ENSRNOG00000009478	0.11	0.07	top1	1	0.07	9.4e-05	5.4	5.4	5.4e-08	0.95	0.07	0.23	TRUE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.