Hub : Genes

L1td1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	L1td1	0.15	0.12	2.8e-11	0.11	0.11	0.1	0.11	1.4e-10	1.0e-10	1.5e-09	4.3e-10
2	pVTA	gene expression	L1td1	0.04	0.04	8.0e-04	0.02	0.03	0.01	0.01	5.0e-03	3.3e-03	2.0e-02	2.2e-02
3	IC	alternative TSS	XM_063288429.1	0.73	0.03	1.6e-03	0.02	0.02	-0	-0	4.3e-02	5.7e-02	5.0e-01	4.4e-01
4	PL	gene expression	L1td1	0.04	0.04	7.3e-05	0.04	0.04	0.05	0.04	7.7e-05	6.1e-05	6.5e-06	9.0e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.4	0.7	0.8	0.9	0.9	-0.9	-0.6
Area under the delay curve	0.4	0.7	1.0	0.9	0.9	-1.0	-0.3
BMI with tail	0.5	1.9	2.4	-1.4	-1.4	1.5	1.0
BMI without tail	0.6	3.0	3.5	-1.9	-1.9	1.8	1.3
Body weight	0.1	0.4	0.6	-0.8	-0.7	0.5	0.6
Weight adjusted by age	0.4	1.1	1.5	-1.2	-1.2	1.1	0.7
Bone surface	1.4	2.8	3.4	-1.8	-1.8	1.8	1.1
Bone volume	0.3	0.5	0.7	-0.8	-0.8	0.8	0.5
Breakpoint value in progressive ratio session	0.3	0.6	1.2	0.7	0.7	-1.1	-0.6
Number of licking bursts	0.0	0.1	0.1	-0.3	-0.3	0.2	0.2
Context. condit. distance diff. score	2.3	2.8	3.2	1.8	1.8	-1.8	-1.2
Locomotion velocity, session 1	0.0	0.0	0.1	-0.2	-0.2	0.1	0.2
Locomotion distance, session 1	0.6	0.8	1.0	0.9	0.9	-1.0	-0.6
Locomotion velocity, session 2	0.2	0.2	0.3	-0.5	-0.5	0.5	0.3
Locomotion distance, session 2	0.1	0.1	0.2	-0.4	-0.4	0.2	0.5
Locomotion velocity, session 3	0.0	0.0	0.0	0.0	0.0	-0.0	0.1
Locomotion distance, session 3	0.0	0.0	0.0	0.0	0.0	-0.0	0.2
Stereotopy head waving bouts, day 3	0.4	0.5	0.6	0.7	0.7	-0.8	-0.5
Stereotopy head waving duration, day 3	0.7	0.8	1.1	0.9	0.9	-1.0	-0.7
Locomotion velocity, session 7	0.2	0.2	0.3	0.5	0.5	-0.6	-0.3
Locomotion distance, session 7	0.2	0.3	0.3	0.5	0.5	-0.6	-0.3
Stereotopy head waving bouts, day 7	0.9	1.1	1.2	-1.1	-1.1	1.0	0.8
Stereotopy head waving duration, day 7	0.9	1.2	1.3	-1.2	-1.1	1.1	0.9
Locomotion velocity, session 8	0.3	0.4	0.5	0.7	0.7	-0.7	-0.4
Locomotion distance, session 8	0.8	1.2	1.5	1.1	1.1	-1.2	-0.7
Degree of sensitization distance	0.1	0.1	0.1	-0.3	-0.3	0.3	0.1
Degree of sensitization stereotypy	1.1	1.3	1.4	-1.2	-1.2	1.2	0.9
Conditioned locomotion	0.0	0.0	0.0	0.1	0.1	-0.1	-0.0
Cocaine response after cond. corrected	0.4	0.7	0.8	-0.9	-0.9	0.9	0.5
Cocaine response after cond. not corrected	0.4	0.5	0.7	-0.8	-0.8	0.8	0.4
Cocaine response before conditioning	0.0	0.0	0.0	0.1	0.1	0.0	-0.0
Saline control response	0.0	0.0	0.1	0.2	0.2	-0.2	-0.1
Bone: connectivity density	1.0	1.6	1.9	-1.4	-1.4	1.4	0.9
Bone: cortical apparent density	4.3	6.8	7.8	2.8	2.8	-2.8	-1.9
Bone: cortical area	0.2	0.3	0.4	-0.6	-0.6	0.5	0.4
Bone: cortical porosity	0.3	0.3	0.4	-0.6	-0.6	0.6	0.5
Bone: cortical porosity	0.5	0.5	0.6	-0.8	-0.8	0.7	0.6
Bone: cortical thickness	0.2	0.3	0.4	0.6	0.6	-0.6	-0.3
Bone: cortical thickness	0.0	0.0	0.0	0.2	0.2	-0.2	-0.2
Bone: cortical tissue density	4.2	6.7	7.7	2.8	2.8	-2.8	-2.0
Condit. Reinf. active minus inactive responses	0.0	0.0	0.0	-0.1	-0.1	0.1	0.1
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.1	0.3	0.3	-0.3	-0.2
Condit. Reinf. active responses	0.2	0.2	0.3	-0.6	-0.6	0.4	0.4
Condit. Reinf. inactive responses	0.2	0.2	0.3	-0.6	-0.6	0.5	0.4
Incentive salience index mean	0.0	0.0	0.0	-0.1	-0.1	0.1	0.1
Condit. Reinf. lever presses	0.1	0.1	0.2	0.3	0.3	-0.4	-0.2
Condit. Reinf. active minus inactive responses	0.8	1.2	1.5	1.2	1.2	-1.2	-0.7
Condit. Reinf. active-inactive response ratio	0.2	0.4	0.5	0.7	0.7	-0.7	-0.4
Condit. Reinf. active responses	0.7	1.0	1.3	1.1	1.1	-1.1	-0.5
Condit. Reinf. inactive responses	1.2	1.7	2.2	1.5	1.5	-1.5	-0.7
Condit. Reinf. lever presses	1.6	2.3	2.6	-1.6	-1.6	1.6	1.2
Condit. Reinf. lever reinforcers received	0.3	0.4	0.5	0.7	0.7	-0.7	-0.2
Conditioned reinforcement - actives	0.0	0.1	0.1	0.2	0.2	-0.1	-0.3
Conditioned reinforcement - inactives	0.3	0.7	1.2	0.7	0.7	-1.1	-0.7
Conditioned locomotion	0.2	0.3	0.4	0.5	0.5	-0.6	-0.3
Patch foraging indifference point 0 sec	3.1	8.7	10.3	-3.2	-3.2	3.1	2.1
Patch foraging indifference point AUC	0.4	1.0	1.3	-1.1	-1.1	0.9	0.8
Delay disc. indifference point, 0s delay	1.6	1.8	2.3	1.5	1.5	-1.4	-0.9
Delay disc. indifference point, 16s delay	0.4	0.5	0.6	-0.8	-0.8	0.6	0.8
Delay disc. indifference point, 2s delay	0.2	0.2	0.2	0.5	0.5	-0.5	-0.1
Delay disc. indifference point, 24s delay	0.1	0.2	0.3	0.5	0.5	-0.6	-0.1
Delay disc. indifference point, 4s delay	2.7	2.9	3.8	1.9	1.9	-1.9	-0.8
Delay disc. indifference point, 8s delay	1.0	1.7	2.1	1.4	1.4	-1.5	-0.7
Indifference point function ln k	0.0	0.1	0.2	0.4	0.4	-0.3	-0.4
Indifference point function log k	0.0	0.1	0.2	0.4	0.4	-0.3	-0.4
Patch foraging total patch changes 0 sec	2.8	8.1	9.6	-3.1	-3.1	3.0	2.1
Patch foraging total patch changes 12 sec	0.7	0.9	0.9	-0.9	-0.9	1.0	0.9
Patch foraging total patch changes 18 sec	0.8	1.9	2.4	-1.6	-1.5	1.3	1.1
Patch foraging total patch changes 24 sec	0.5	1.7	2.1	-1.4	-1.4	1.2	1.0
Patch foraging total patch changes 6 sec	1.7	2.8	3.4	-1.8	-1.8	1.6	1.4
Patch foraging time to switch 0 sec	0.6	2.2	2.8	1.6	1.6	-1.7	-1.0
Patch foraging water rate 0 sec	0.6	2.1	2.6	-1.6	-1.6	1.5	1.0
Patch foraging water rate 12 sec	1.1	4.3	5.2	-2.3	-2.2	2.1	1.7
Patch foraging water rate 18 sec	0.1	0.2	0.2	-0.5	-0.4	0.3	0.4
Patch foraging water rate 24 sec	0.0	0.0	0.0	-0.1	-0.0	-0.1	0.1
Patch foraging water rate 6 sec	0.1	0.2	0.2	-0.5	-0.5	0.4	-0.0
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.1	0.2	0.2	-0.3	0.0
Distance traveled before self-admin	0.1	0.1	0.2	-0.4	-0.4	-0.2	0.4
Distance traveled after self-admin	0.2	0.4	0.8	-0.7	-0.6	-0.1	0.9
Extensor digitorum longus weight	0.5	2.1	2.5	1.5	1.5	-1.6	-1.1
Bone: elastic displacement	0.6	0.7	0.9	0.9	0.9	-0.9	-0.7
Bone: elastic work	1.6	2.0	2.4	1.5	1.5	-1.5	-1.1
Bone: endosteal estimation	0.6	1.6	1.9	-1.4	-1.4	1.4	0.8
Bone: endosteal perimeter	1.1	2.6	3.2	-1.8	-1.8	1.7	1.1
Epididymis fat weight	0.0	0.2	0.5	0.4	0.4	-0.7	-0.1
Delta time in closed arm before/after self-admin	0.0	0.0	0.1	-0.0	-0.1	0.3	-0.3
Delta time in open arm before/after self-admin	1.4	1.6	1.9	-1.3	-1.3	1.4	1.1
Diff in mean of infusions in LGA sessions	0.1	0.1	0.2	-0.4	-0.4	0.2	0.1
Delay discount exponential model param	0.5	0.7	1.1	-0.9	-0.9	1.0	0.2
Extinction: sum of active levers before priming	0.2	0.4	0.7	0.6	0.6	-0.9	-0.3
Active lever presses in extinction session 6	0.0	0.0	0.1	-0.1	-0.1	-0.1	-0.3
Bone: final force	0.2	0.3	0.3	0.6	0.6	-0.5	-0.5
Bone: final moment	0.0	0.0	0.0	-0.0	-0.1	0.1	-0.1
Food consumed during 24 hour testing period	0.2	0.3	0.5	0.6	0.6	-0.7	-0.3
Glucose	0.1	0.1	0.2	-0.4	-0.4	0.4	0.2
Heart weight	2.0	3.3	3.8	2.0	1.9	-1.9	-1.4
Delay discount hyperbolic model param	0.5	0.6	0.9	-0.9	-0.9	1.0	0.2
Intermittent access intake day 1-15 change	0.0	0.1	0.3	0.3	0.3	-0.6	-0.2
Intermittent access intake escalation	0.1	0.3	0.5	0.5	0.5	-0.7	-0.3
Intermittent access intake escalation 2	0.1	0.2	0.5	0.4	0.4	-0.7	-0.2
Intermitt. access day 1 inactive lever presses	0.0	0.1	0.2	-0.3	-0.3	0.5	0.3
Intermitt. access day 15 inactive lever presses	0.3	1.5	1.8	1.3	1.3	-1.3	-0.9
Intermitt. access escalation Index	0.1	0.4	1.0	-0.5	-0.6	1.0	0.0
Intermittent access day 1 total infusions	0.3	1.0	1.3	1.1	1.2	-0.9	-0.7
Intermittent access day 15 total infusions	0.3	0.8	1.0	1.0	1.0	-0.9	-0.7
Intermittent access terminal intake (last 3 days)	0.2	0.4	0.6	0.6	0.7	-0.8	-0.4
Intermittent access total infusions	0.9	1.1	1.4	1.2	1.2	-0.9	-0.8
Intermittent access day 1 locomotion	0.0	0.0	0.0	0.2	0.2	0.0	0.0
Intermittent access day 15 total locomotion	0.0	0.0	0.0	-0.0	0.0	0.0	0.2
Intermittent access total locomotion	0.0	0.0	0.0	-0.0	-0.0	0.2	0.1
Intermittent access standard deviation	0.1	0.6	0.7	0.8	0.9	-0.8	-0.6
Left kidney weight	0.1	0.4	0.6	0.7	0.7	-0.7	-0.2
Right kidney weight	0.1	0.5	0.8	0.7	0.8	-0.9	-0.3
Cocaine induced anxiety	0.0	0.0	0.1	-0.0	-0.0	0.3	0.2
Post-drug Anxiety	0.0	0.0	0.0	0.2	0.2	0.1	-0.2
Baseline Anxiety	0.0	0.0	0.0	0.0	0.0	0.0	-0.2
Tail length	0.1	0.5	1.1	0.6	0.6	-1.1	-0.3
Length with tail	0.1	0.5	1.2	0.5	0.6	-1.1	-0.3
Length without tail	0.0	0.1	0.2	0.2	0.2	-0.5	-0.1
Times rat made contact with spout	0.0	0.0	0.0	-0.1	-0.1	0.1	0.1
Lifetime Intake	0.9	1.1	1.5	1.2	1.2	-1.0	-0.8
Liver weight, left	2.6	4.5	6.0	2.2	2.3	-2.4	-1.4
Liver weight, right	1.9	3.4	4.6	1.9	2.0	-2.1	-1.2
Locomotor activity	0.0	0.0	0.0	0.0	0.0	-0.1	0.0
Locomotor testing distance	0.7	1.8	2.2	-1.5	-1.5	1.3	1.0
Locomotor testing rearing	0.0	0.0	0.1	0.1	0.1	-0.2	0.2
Locomotion in novel chamber	1.8	2.4	2.9	-1.7	-1.7	1.7	1.1
Locomotion in novel chamber post-restriction	0.1	0.3	0.6	0.6	0.5	-0.4	-0.8
Fecal boli incidents, locomotor time 1	0.0	0.0	0.0	-0.0	0.0	0.1	0.0
Change in fecal boli incidents, locomotor task	0.1	0.1	0.1	0.4	0.4	-0.4	-0.2
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.1	-0.4	-0.4	0.4	0.3
Bouts of movement, locomotor time 1	0.0	0.0	0.1	-0.2	-0.1	0.3	0.1
Total resting periods, locomotor time 1	0.0	0.1	0.1	-0.2	-0.2	0.3	0.1
Rest time, locomotor task time 1	0.2	0.3	0.3	-0.6	-0.5	0.3	0.6
Distance moved, locomotor task time 1	0.1	0.2	0.4	0.4	0.3	-0.1	-0.7
Vertical activity count, locomotor time 1	0.0	0.2	0.4	-0.5	-0.5	0.6	0.2
Time >=10cm from walls, locomotor time 2	0.8	2.4	2.9	1.7	1.7	-1.5	-1.2
Bouts of movement, locomotor time 2	0.2	0.6	1.0	-0.8	-0.8	1.0	0.4
Total resting periods, locomotor time 2	0.2	0.7	1.1	-0.8	-0.8	1.1	0.5
Rest time, locomotor task time 2	0.4	0.7	0.9	-0.9	-0.9	0.6	1.0
Distance moved, locomotor task time 2	0.9	1.2	1.5	1.2	1.1	-0.9	-1.2
Vertical activity count, locomotor time 2	0.1	0.2	0.3	0.5	0.5	-0.4	-0.5
Light reinforcement 1	0.1	0.7	1.0	0.8	0.9	-1.0	-0.5
Light reinforcement 2	0.1	0.2	0.2	0.5	0.4	-0.4	-0.4
Bone: marrow area	0.5	1.3	1.6	-1.3	-1.3	1.3	0.7
Bone: maximum diameter	0.3	0.7	0.9	-0.9	-0.9	0.8	0.5
Bone: maximum force	0.0	0.0	0.0	0.1	0.1	-0.1	-0.1
Bone: maximum moment	0.1	0.3	0.3	-0.6	-0.6	0.5	0.3
Mean time between licks in bursts	1.1	6.9	8.1	2.9	2.8	-2.8	-1.9
Mean num. licks in bursts	0.0	0.0	0.0	0.1	0.1	-0.0	-0.1
Cd content in liver	0.8	0.8	1.0	-1.0	-1.0	1.0	0.6
Co content in liver	0.1	0.1	0.1	0.2	0.2	-0.3	-0.2
Cu content in liver	0.7	0.9	1.1	1.0	1.0	-0.9	-0.7
Fe content in liver	0.0	0.0	0.0	0.2	0.2	-0.0	-0.0
K content in liver	1.6	1.5	2.0	1.3	1.3	-1.4	-0.8
Mg content in liver	0.4	0.4	0.6	-0.8	-0.8	0.6	0.5
Mn content in liver	0.1	0.1	0.1	-0.3	-0.3	0.2	0.1
Na content in liver	2.7	3.1	3.7	1.9	1.9	-1.8	-1.2
Rb content in liver	0.4	0.4	0.7	0.6	0.6	-0.8	-0.5
Se content in liver	0.1	0.2	0.3	-0.4	-0.4	0.5	0.3
Sr content in liver	1.1	1.0	1.1	-1.0	-1.0	1.1	0.8
Zn content in liver	0.8	0.9	1.0	-1.0	-1.0	1.0	0.7
Bone: minimum diameter	1.3	2.5	3.1	-1.8	-1.7	1.6	1.1
Time in familiar zone, hab. session 1	2.2	2.4	3.0	1.7	1.7	-1.7	-1.1
Time in novel zone, hab. session 1	5.7	6.4	7.8	-2.7	-2.7	2.8	1.7
Total zone transitions, hab. session 1	1.4	1.9	2.4	1.5	1.5	-1.5	-1.0
Total locomotion distance, hab. session 1	0.0	0.1	0.1	0.3	0.3	-0.3	-0.2
Locomotion velocity, hab. session 1	0.1	0.1	0.2	0.3	0.3	-0.4	-0.2
Time in familiar zone, hab. session 2	0.4	0.5	0.6	0.8	0.8	-0.8	-0.5
Time in novel zone, hab. session 2	0.9	1.0	1.2	-1.1	-1.1	1.1	0.6
Total zone transitions, hab. session 2	3.8	4.8	5.7	2.3	2.4	-2.4	-1.6
Total locomotion distance, hab. session 2	1.6	2.0	2.5	1.5	1.5	-1.6	-1.0
Locomotion velocity, hab. session 2	1.3	1.7	2.2	1.4	1.4	-1.5	-0.9
Novel to familiar place preference ratio	0.7	0.9	1.1	-1.1	-1.1	1.1	0.6
Novelty place preference	0.5	0.6	0.8	-0.9	-0.9	0.9	0.4
Time in novel zone, NPP test	0.8	1.0	1.3	-1.1	-1.1	1.1	0.6
Total zone transitions, NPP test	1.5	2.2	2.9	1.5	1.6	-1.7	-1.0
Total locomotion distance, NPP test	0.1	0.2	0.3	0.4	0.4	-0.5	-0.3
Locomotion velocity, NPP test	0.3	0.4	0.6	0.6	0.6	-0.8	-0.4
Intraocular pressure	0.0	0.0	0.0	0.2	0.2	0.2	-0.0
Delta distance traveled before/after self-admin	0.2	0.2	0.3	-0.5	-0.5	0.3	0.5
Delta ambulatory time before/after self-admin	0.1	0.1	0.3	-0.3	-0.2	-0.0	0.6
Parametrial fat weight	5.9	13.9	16.7	-4.0	-4.1	4.1	2.5
Pavlov. Cond. lever latency	0.2	0.2	0.4	0.5	0.5	-0.6	-0.2
Pavlov. Cond. magazine entry latency	0.3	0.4	0.5	0.7	0.7	-0.7	-0.5
Pavlov. Cond. change in total contacts	0.3	0.4	0.5	-0.6	-0.7	0.7	0.3
Pavlov. Cond. index score	0.0	0.0	0.0	0.1	0.0	0.0	-0.1
Pavlov. Cond. latency score	0.0	0.0	0.0	-0.0	-0.1	0.1	-0.1
Pavlov. Cond. lever contacts	0.0	0.0	0.0	-0.1	-0.1	0.2	-0.0
Pavlov. Cond. magazine entry number	0.7	0.9	1.1	-1.0	-1.0	1.0	0.7
Pavlov. Cond. intertrial magazine entries	0.6	0.7	0.9	0.9	0.9	-1.0	-0.6
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.0	-0.1	-0.1	0.2	-0.0
Pavlov. Cond. response bias	0.1	0.2	0.2	0.4	0.4	-0.4	-0.4
Pavlov. Cond. lever latency	1.3	1.9	2.2	1.5	1.5	-1.5	-1.1
Pavlov. Cond. magazine entry latency	1.0	1.5	1.7	-1.3	-1.3	1.3	1.0
Pavlov. Cond. change in total contacts	0.9	2.2	2.6	-1.6	-1.6	1.6	1.1
Pavlov. Cond. index score	1.0	1.5	1.8	-1.3	-1.3	1.4	1.0
Pavlov. Cond. latency score	0.8	1.3	1.5	-1.2	-1.2	1.2	0.9
Pavlov. Cond. lever contacts	1.4	2.1	2.4	-1.5	-1.5	1.6	1.1
Pavlov. Cond. magazine entry number	0.3	0.4	0.5	0.6	0.6	-0.7	-0.6
Pavlov. Cond. intertrial magazine entries	0.6	1.4	1.6	1.2	1.2	-1.3	-0.9
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.7	2.0	-1.4	-1.4	1.4	1.0
Pavlov. Cond. response bias	1.2	1.6	1.8	-1.3	-1.3	1.4	1.0
Time in closed arm before self-admin	0.1	0.1	0.2	0.4	0.4	-0.3	-0.1
Time in closed arm after self-admin	0.1	0.1	0.1	0.4	0.3	0.2	-0.2
Time in open arm before self-admin	0.1	0.1	0.3	-0.5	-0.5	-0.2	0.2
Time in open arm after self-admin	2.5	2.7	3.5	-1.9	-1.8	1.5	1.4
Bone: periosteal estimation	0.5	1.3	1.6	-1.3	-1.3	1.2	0.7
Bone: periosteal perimeter	0.4	0.7	0.9	-0.9	-0.9	0.8	0.6
Bone: post-yield work	1.1	1.9	2.3	-1.5	-1.5	1.5	0.9
Progressive ratio test 1 active lever presses	1.7	3.0	3.9	2.0	2.0	-1.6	-1.3
Progressive ratio test 1 breakpoint	2.1	3.6	4.5	2.1	2.1	-1.8	-1.4
Progressive ratio test 1 inactive lever presses	1.5	3.8	5.0	2.2	2.2	-2.0	-1.2
Progressive ratio test 2 active lever presses	0.1	0.1	0.1	0.4	0.4	-0.3	-0.3
Progressive ratio test 2 breakpoint	0.2	0.2	0.3	0.5	0.5	-0.5	-0.4
Progressive ratio test 2 inactive lever presses	0.1	0.5	0.6	0.7	0.7	-0.8	-0.5
Incentive Sensitization - Responses	0.1	0.2	0.3	-0.5	-0.5	0.5	0.2
Incentive Sensitization - Breakpoint	0.2	0.4	0.5	-0.7	-0.7	0.7	0.3
Sum of active levers in priming session hrs 5-6	0.4	0.4	0.8	0.5	0.6	-0.9	-0.3
Progressive ratio	0.1	0.3	0.5	0.5	0.5	-0.7	-0.4
Food seeking constrained by brief footshock	4.0	5.0	5.7	2.4	2.3	-2.3	-1.9
Seeking ratio, punishment vs. effort	0.4	1.0	1.3	1.1	1.1	-0.9	-0.8
Retroperitoneal fat weight	0.4	1.7	2.1	-1.5	-1.4	1.2	1.0
Reaction time number correct	0.0	0.0	0.1	-0.2	-0.2	-0.1	0.3
Reaction time mean minus median	0.1	0.4	0.6	-0.8	-0.7	0.5	0.7
Reaction time mean minus median AUC	0.0	0.1	0.1	-0.3	-0.3	0.1	0.4
Reaction time num false alarms	0.1	0.2	0.2	-0.5	-0.5	0.4	0.3
Reaction time num false alarms AUC	0.3	0.7	0.9	-0.9	-0.9	0.9	0.6
Reaction time trials correct on left	0.0	0.0	0.1	-0.2	-0.2	-0.1	0.3
Reaction time trials on left	0.0	0.1	0.1	-0.3	-0.2	-0.1	0.4
Reaction time mean	0.5	1.0	1.2	-1.1	-1.1	1.1	0.7
Reaction time mean AUC	0.2	0.5	0.6	-0.7	-0.8	0.7	0.6
Median of all reaction times	0.7	1.2	1.6	-1.1	-1.2	1.3	0.7
Reaction time omissions	0.6	0.9	1.2	-1.0	-1.0	1.1	0.7
Reaction time false alarm rate	0.6	0.8	1.1	-0.9	-1.0	1.0	0.6
Reaction time premature initiation rate	0.2	0.4	0.5	0.7	0.7	-0.7	0.1
Reaction time premature initiations	0.2	0.6	1.0	0.8	0.8	-1.0	0.1
Std. dev. reaction times	0.7	2.2	2.7	-1.6	-1.7	1.4	1.2
Reaction time trials completed	0.0	0.1	0.1	-0.3	-0.2	-0.1	0.4
Reaction time trials AUC	0.0	0.1	0.1	-0.3	-0.2	-0.1	0.3
Run reversals in cocaine runway, females	0.1	0.1	0.1	0.3	0.3	-0.3	-0.1
Run reversals in cocaine runway, males	0.5	0.6	0.6	-0.8	-0.7	0.7	0.8
Latency to leave start box in cocaine runway	0.2	0.3	0.3	0.5	0.5	-0.5	-0.4
Latency to leave start box in cocaine runway, F	0.1	0.1	0.2	-0.4	-0.4	0.4	0.2
Latency to leave start box in cocaine runway, M	0.9	0.8	1.0	1.0	1.0	-0.9	-0.7
Std. dev. time between licks in bursts	0.0	0.0	0.0	-0.1	-0.1	0.1	0.0
Total sessions with >9 infusions	1.8	2.2	2.8	1.6	1.6	-1.7	-0.9
Short access day 1 total inactive lever presses	0.1	0.1	0.3	0.3	0.3	-0.2	-0.5
Short access day 10 total inactive lever presses	0.3	1.9	2.7	-1.4	-1.4	1.6	1.0
Short access day 1 total infusions	0.1	0.2	0.3	0.5	0.5	-0.3	-0.5
Short access day 10 total infusions	0.9	1.5	1.8	1.3	1.3	-1.4	-0.8
Short access total infusions	0.5	0.8	1.0	1.0	1.0	-0.8	-0.6
Short access day 1 locomotion	0.0	0.0	0.1	0.2	0.2	0.1	-0.2
Short access day 10 total locomotion	0.1	0.4	0.6	-0.6	-0.6	0.8	0.4
Short access total locomotion	0.1	0.2	0.3	0.6	0.6	-0.4	-0.3
One hour access (0.3 mA shock)	0.0	0.0	0.0	0.2	0.2	-0.2	0.0
Compulsive drug intake	2.4	3.5	4.8	-1.9	-1.9	2.2	1.4
One hour access (shock baseline)	0.9	2.2	2.9	1.6	1.6	-1.7	-1.0
Social response proportion	0.7	0.9	1.4	-1.0	-1.1	1.2	0.4
Social responses	0.5	0.7	0.8	0.9	0.9	-0.9	-0.6
Social time	0.0	0.0	0.0	0.1	0.0	-0.0	-0.1
Soleus weight	0.0	0.1	0.1	0.3	0.3	-0.3	-0.3
Bone: stiffness	0.0	0.0	0.0	0.0	0.0	-0.1	0.1
Tibialis anterior weight	6.9	23.8	27.8	-5.3	-5.3	5.3	3.4
Time to tail flick, vehicle, before self-admin	0.8	1.0	1.6	-1.2	-1.2	0.8	0.6
Time to tail flick, vehicle, after self-admin	0.7	1.5	1.8	-1.4	-1.3	1.1	1.1
Time to tail flick, test, before self-admin	0.0	0.0	0.1	-0.0	0.0	-0.3	0.1
Time to tail flick, test, after self-admin	0.2	0.2	0.4	0.4	0.4	-0.6	-0.1
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.1	0.3	0.2	-0.0	0.1
Delta time to tail flick, test, before/after SA	0.1	0.1	0.2	-0.4	-0.4	0.5	0.3
Tibia length	2.3	6.4	7.8	2.7	2.7	-2.8	-1.7
Ambulatory time before self-admin	0.0	0.1	0.3	-0.1	-0.0	-0.5	0.2
Ambulatory time after self-admin	0.1	0.2	0.3	-0.4	-0.4	-0.2	0.6
Bone: tissue strength	0.1	0.1	0.2	-0.4	-0.4	0.4	0.1
Total heroin consumption	0.3	0.4	0.5	0.5	0.5	-0.7	-0.7
Bone: trabecular number	0.1	0.2	0.3	0.5	0.5	-0.5	-0.3
Bone: trabecular spacing	0.0	0.0	0.0	0.0	-0.0	0.0	-0.1
Bone: trabecular thickness	0.1	0.1	0.2	0.4	0.4	-0.4	-0.3
Bone: trabecular tissue density	10.2	17.8	20.7	4.6	4.5	-4.5	-3.1
Water consumed over 24 hours	0.0	0.0	0.0	-0.0	-0.0	0.0	0.0
Number of responses in last shaping day	0.1	0.1	0.2	0.4	0.4	-0.4	-0.2