Intraocular pressure

Intraocular pressure, average of right and left eye

Tags: Physiology

Project: eye_pressure

2 loci · 2 genes with independent associations · 2 total associated genes

Significant Loci

# Chr Start pos End pos # assoc genes # joint models Best TWAS P Best GWAS P Cond GWAS P Joint genes
1 chr9 75969545 77365260 1 1 2.14e-17 1.24e-01 1e+00 Zfand2b
2 chr20 53722628 54429288 1 1 5.55e-09 2.81e-01 1e+00 LOC103694460

Pleiotropic Associations

Trait Chi2 ratio # genes+ # genes++ % genes++ Corr Corr P Genes
BMI with tail 15.87 2 2 100 0 1e+00 LOC103694460 Zfand2b
BMI without tail 30.04 2 1 50 0 1e+00 LOC103694460 Zfand2b
Body weight 14.21 1 1 50 0 1e+00 LOC103694460
Epididymis fat weight 111.28 1 1 50 0 1e+00 Zfand2b
Heart weight 71.7 1 1 50 0 1e+00 Zfand2b
Left kidney weight 21.23 2 2 100 0 1e+00 LOC103694460 Zfand2b
Right kidney weight 33.33 2 2 100 0 1e+00 LOC103694460 Zfand2b
Tail length 125.62 1 1 50 0 1e+00 Zfand2b
Length with tail 4.78 1 0 0 0 1e+00 Zfand2b
Length without tail 77.43 1 1 50 0 1e+00 Zfand2b
Liver weight, left 10.61 1 0 0 0 1e+00 LOC103694460
Liver weight, right 20.68 2 2 100 0 1e+00 LOC103694460 Zfand2b
Parametrial fat weight 8.47 2 0 0 0 1e+00 LOC103694460 Zfand2b
Retroperitoneal fat weight 18.33 2 1 50 0 1e+00 LOC103694460 Zfand2b
Extensor digitorum longus weight 5.18 1 0 0 0 1e+00 LOC103694460
Soleus weight 2.3 1 0 0 0 1e+00 LOC103694460
Tibialis anterior weight 6.67 2 1 50 0 1e+00 LOC103694460 Zfand2b
Tibia length 4.63 1 0 0 0 1e+00 LOC103694460
Number of licking bursts 32.5 1 1 50 0 1e+00 Zfand2b
Food consumed during 24 hour testing period 15.78 1 0 0 0 1e+00 Zfand2b
Times rat made contact with spout 9.25 1 0 0 0 1e+00 Zfand2b
Mean time between licks in bursts 9.22 1 0 0 0 1e+00 Zfand2b
Mean num. licks in bursts 18.13 1 0 0 0 1e+00 Zfand2b
Std. dev. time between licks in bursts 12.12 1 0 0 0 1e+00 Zfand2b
Water consumed over 24 hours 34.33 1 1 50 0 1e+00 Zfand2b
Patch foraging indifference point 0 sec 12.38 2 0 0 0 1e+00 LOC103694460 Zfand2b
Patch foraging indifference point AUC 18.15 2 1 50 0 1e+00 LOC103694460 Zfand2b
Indifference point function ln k 54.42 1 1 50 0 1e+00 Zfand2b
Indifference point function log k 54.42 1 1 50 0 1e+00 Zfand2b
Patch foraging total patch changes 0 sec 18.06 2 1 50 0 1e+00 LOC103694460 Zfand2b
Patch foraging total patch changes 12 sec 7.17 2 0 0 0 1e+00 LOC103694460 Zfand2b
Patch foraging total patch changes 18 sec 29.95 2 1 50 0 1e+00 LOC103694460 Zfand2b
Patch foraging total patch changes 24 sec 43.45 2 1 50 0 1e+00 LOC103694460 Zfand2b
Patch foraging total patch changes 6 sec 24.67 1 1 50 0 1e+00 Zfand2b
Patch foraging time to switch 0 sec 19.87 2 1 50 0 1e+00 LOC103694460 Zfand2b
Patch foraging water rate 0 sec 39.47 1 1 50 0 1e+00 Zfand2b
Patch foraging water rate 12 sec 69.49 1 1 50 0 1e+00 Zfand2b
Patch foraging water rate 18 sec 9.71 1 0 0 0 1e+00 Zfand2b
Patch foraging water rate 24 sec 12.61 1 0 0 0 1e+00 Zfand2b
Patch foraging water rate 6 sec 35.43 1 1 50 0 1e+00 Zfand2b
Locomotor activity 12.38 1 0 0 0 1e+00 Zfand2b
Locomotor testing distance 47.2 1 1 50 0 1e+00 Zfand2b
Locomotor testing rearing 51.79 2 1 50 0 1e+00 LOC103694460 Zfand2b
Light reinforcement 1 13.75 2 1 50 0 1e+00 LOC103694460 Zfand2b
Light reinforcement 2 5.46 2 0 0 0 1e+00 LOC103694460 Zfand2b
Reaction time number correct 114.79 1 1 50 0 1e+00 Zfand2b
Reaction time mean minus median 179.03 1 1 50 0 1e+00 Zfand2b
Reaction time mean minus median AUC 232.47 1 1 50 0 1e+00 Zfand2b
Reaction time num false alarms 4.93 2 0 0 0 1e+00 LOC103694460 Zfand2b
Reaction time num false alarms AUC 27.43 1 1 50 0 1e+00 Zfand2b
Reaction time trials correct on left 114.79 1 1 50 0 1e+00 Zfand2b
Reaction time trials on left 106.69 1 1 50 0 1e+00 Zfand2b
Reaction time mean 36.11 1 1 50 0 1e+00 Zfand2b
Reaction time mean AUC 33.75 1 1 50 0 1e+00 Zfand2b
Median of all reaction times 17.65 1 0 0 0 1e+00 Zfand2b
Reaction time omissions 46.56 1 1 50 0 1e+00 Zfand2b
Reaction time false alarm rate 3.92 1 0 0 0 1e+00 Zfand2b
Reaction time premature initiations 41.6 1 1 50 0 1e+00 Zfand2b
Std. dev. reaction times 72.92 1 1 50 0 1e+00 Zfand2b
Reaction time trials completed 106.69 1 1 50 0 1e+00 Zfand2b
Reaction time trials AUC 108.76 1 1 50 0 1e+00 Zfand2b
Social response proportion 6.01 1 0 0 0 1e+00 Zfand2b
Cocaine response after cond. corrected 12.71 1 0 0 0 1e+00 Zfand2b
Cocaine response after cond. not corrected 10.73 1 0 0 0 1e+00 Zfand2b
Saline control response 7.1 2 0 0 0 1e+00 LOC103694460 Zfand2b
Condit. Reinf. lever presses 5.55 1 0 0 0 1e+00 Zfand2b
Pavlov. Cond. lever latency 9.22 1 0 0 0 1e+00 LOC103694460
Pavlov. Cond. change in total contacts 4.63 1 0 0 0 1e+00 LOC103694460
Pavlov. Cond. index score 15.43 1 0 0 0 1e+00 LOC103694460
Pavlov. Cond. latency score 10.76 1 0 0 0 1e+00 LOC103694460
Pavlov. Cond. lever contacts 8.82 1 0 0 0 1e+00 LOC103694460
Pavlov. Cond. magazine entry number 20.26 1 0 0 0 1e+00 LOC103694460
Pavlov. Cond. lever-magazine prob. diff. 10.41 1 0 0 0 1e+00 LOC103694460
Pavlov. Cond. response bias 13.13 1 0 0 0 1e+00 LOC103694460
Conditioned reinforcement - actives 152.54 1 1 50 0 1e+00 Zfand2b
Conditioned reinforcement - inactives 135.63 1 1 50 0 1e+00 Zfand2b
Conditioned locomotion 13.93 1 0 0 0 1e+00 Zfand2b
Intermittent access intake day 1-15 change 156.77 1 1 50 0 1e+00 Zfand2b
Intermittent access intake escalation 117.41 1 1 50 0 1e+00 Zfand2b
Intermitt. access day 1 inactive lever presses 169.63 1 1 50 0 1e+00 Zfand2b
Intermitt. access day 15 inactive lever presses 294.26 1 1 50 0 1e+00 Zfand2b
Intermittent access day 1 total infusions 71.42 1 1 50 0 1e+00 Zfand2b
Intermittent access day 15 total infusions 35.39 1 1 50 0 1e+00 Zfand2b
Intermittent access terminal intake (last 3 days) 25.82 1 1 50 0 1e+00 Zfand2b
Intermittent access day 1 locomotion 26.47 1 1 50 0 1e+00 Zfand2b
Intermittent access day 15 total locomotion 93.08 1 1 50 0 1e+00 Zfand2b
Intermittent access total locomotion 12.43 1 0 0 0 1e+00 Zfand2b
Intermittent access standard deviation 442.51 1 1 50 0 1e+00 Zfand2b
Cocaine induced anxiety 125.35 1 1 50 0 1e+00 Zfand2b
Baseline Anxiety 393.92 1 1 50 0 1e+00 Zfand2b
Incentive Sensitization - Responses 309.83 1 1 50 0 1e+00 Zfand2b
Incentive Sensitization - Breakpoint 300.45 1 1 50 0 1e+00 Zfand2b
Progressive ratio test 1 active lever presses 26.41 1 1 50 0 1e+00 Zfand2b
Progressive ratio test 1 breakpoint 19.19 1 0 0 0 1e+00 Zfand2b
Progressive ratio test 2 active lever presses 109.22 1 1 50 0 1e+00 Zfand2b
Progressive ratio test 2 breakpoint 106.65 1 1 50 0 1e+00 Zfand2b
Progressive ratio test 2 inactive lever presses 63.47 1 1 50 0 1e+00 Zfand2b
Short access day 1 total inactive lever presses 21.93 1 0 0 0 1e+00 Zfand2b
Short access day 10 total inactive lever presses 43.04 1 1 50 0 1e+00 Zfand2b
Short access day 1 locomotion 129.19 1 1 50 0 1e+00 Zfand2b
Short access day 10 total locomotion 432.47 1 1 50 0 1e+00 Zfand2b
Short access total locomotion 209.96 1 1 50 0 1e+00 Zfand2b
Compulsive drug intake 68.39 1 1 50 0 1e+00 Zfand2b
One hour access (0.3 mA shock) 22.58 1 0 0 0 1e+00 Zfand2b
Number of responses in last shaping day 67.75 1 1 50 0 1e+00 Zfand2b
Locomotion velocity, session 2 13.34 1 0 0 0 1e+00 LOC103694460
Locomotion distance, session 2 7.53 2 0 0 0 1e+00 LOC103694460 Zfand2b
Locomotion velocity, session 3 7.97 1 0 0 0 1e+00 LOC103694460
Locomotion distance, session 3 4.68 1 0 0 0 1e+00 LOC103694460
Locomotion distance, session 7 9.27 1 0 0 0 1e+00 LOC103694460
Stereotopy head waving bouts, day 7 7.71 1 0 0 0 1e+00 LOC103694460
Stereotopy head waving duration, day 7 11.78 1 0 0 0 1e+00 LOC103694460
Locomotion distance, session 8 8.35 1 0 0 0 1e+00 LOC103694460
Degree of sensitization stereotypy 6.17 1 0 0 0 1e+00 LOC103694460
Pavlov. Cond. intertrial magazine entries 7.44 1 0 0 0 1e+00 LOC103694460
Bone: cortical area 7.41 1 0 0 0 1e+00 LOC103694460
Bone: cortical porosity 16.96 1 0 0 0 1e+00 LOC103694460
Bone: cortical porosity 8.89 1 0 0 0 1e+00 LOC103694460
Bone: elastic displacement 5.56 1 0 0 0 1e+00 Zfand2b
Bone: elastic work 11.21 1 0 0 0 1e+00 LOC103694460
Bone: endosteal estimation 4.34 1 0 0 0 1e+00 LOC103694460
Bone: endosteal perimeter 25.18 1 1 50 0 1e+00 LOC103694460
Bone: marrow area 3.21 1 0 0 0 1e+00 LOC103694460
Bone: maximum diameter 23.35 1 1 50 0 1e+00 LOC103694460
Bone: minimum diameter 9.46 1 0 0 0 1e+00 LOC103694460
Bone: periosteal perimeter 11.58 1 0 0 0 1e+00 LOC103694460
Bone: trabecular spacing 8.2 1 0 0 0 1e+00 LOC103694460
Bone: trabecular tissue density 10.67 1 0 0 0 1e+00 LOC103694460
Distance traveled before self-admin 5.58 1 0 0 0 1e+00 Zfand2b
Distance traveled after self-admin 8.9 1 0 0 0 1e+00 Zfand2b
Delta time in open arm before/after self-admin 26.67 1 0 0 0 1e+00 Zfand2b
Active lever presses in extinction session 6 26.41 1 0 0 0 1e+00 Zfand2b
Delta ambulatory time before/after self-admin 6.19 1 0 0 0 1e+00 Zfand2b
Time in closed arm before self-admin 44.32 1 1 50 0 1e+00 Zfand2b
Time in open arm before self-admin 24.67 1 0 0 0 1e+00 Zfand2b
Sum of active levers in priming session hrs 5-6 6.97 1 0 0 0 1e+00 Zfand2b
Time to tail flick, vehicle, after self-admin 75.62 1 1 50 0 1e+00 Zfand2b
Time to tail flick, test, before self-admin 10.68 1 0 0 0 1e+00 Zfand2b
Time to tail flick, test, after self-admin 5.63 1 0 0 0 1e+00 Zfand2b
Delta time to tail flick, vehicle, before/after SA 74.6 1 1 50 0 1e+00 Zfand2b
Ambulatory time before self-admin 25.36 1 0 0 0 1e+00 Zfand2b
Ambulatory time after self-admin 4.73 1 0 0 0 1e+00 Zfand2b
Area under the delay curve 18.5 2 1 50 0 1e+00 LOC103694460 Zfand2b
Delay disc. indifference point, 0s delay 5.71 1 0 0 0 1e+00 Zfand2b
Delay disc. indifference point, 16s delay 69.03 1 1 50 0 1e+00 Zfand2b
Delay disc. indifference point, 2s delay 4.93 1 0 0 0 1e+00 LOC103694460
Delay disc. indifference point, 24s delay 27.43 1 0 0 0 1e+00 Zfand2b
Delay disc. indifference point, 4s delay 7.29 1 0 0 0 1e+00 LOC103694460
Delay disc. indifference point, 8s delay 39.68 2 1 50 0 1e+00 LOC103694460 Zfand2b
Delay discount exponential model param 11.48 2 0 0 0 1e+00 LOC103694460 Zfand2b
Delay discount hyperbolic model param 11.69 2 0 0 0 1e+00 LOC103694460 Zfand2b
Fecal boli incidents, locomotor time 1 176.47 1 1 50 0 1e+00 Zfand2b
Time >=10cm from walls, locomotor time 1 79.04 1 1 50 0 1e+00 Zfand2b
Bouts of movement, locomotor time 1 6.19 1 0 0 0 1e+00 Zfand2b
Rest time, locomotor task time 1 11.47 1 0 0 0 1e+00 Zfand2b
Vertical activity count, locomotor time 1 97.7 1 1 50 0 1e+00 Zfand2b
Bouts of movement, locomotor time 2 23.9 1 0 0 0 1e+00 Zfand2b
Total resting periods, locomotor time 2 36.28 1 1 50 0 1e+00 Zfand2b
Rest time, locomotor task time 2 44.91 1 1 50 0 1e+00 Zfand2b
Distance moved, locomotor task time 2 83.87 1 1 50 0 1e+00 Zfand2b
Vertical activity count, locomotor time 2 13.16 1 0 0 0 1e+00 Zfand2b
Weight adjusted by age 9.91 1 0 0 0 1e+00 Zfand2b
Seeking ratio, delayed vs. immediate footshock 8.74 1 0 0 0 1e+00 Zfand2b
Locomotion in novel chamber post-restriction 14.04 1 0 0 0 1e+00 Zfand2b
Food seeking constrained by brief footshock 14.98 1 0 0 0 1e+00 Zfand2b
Seeking ratio, punishment vs. effort 4.29 1 0 0 0 1e+00 Zfand2b
Run reversals in cocaine runway, females 36.45 1 1 50 0 1e+00 Zfand2b
Latency to leave start box in cocaine runway 34.23 1 1 50 0 1e+00 Zfand2b
Latency to leave start box in cocaine runway, F 31.9 1 1 50 0 1e+00 Zfand2b
Co content in liver 7.64 1 0 0 0 1e+00 LOC103694460
Cu content in liver 43.87 1 1 50 0 1e+00 LOC103694460
Fe content in liver 26.96 1 1 50 0 1e+00 LOC103694460
K content in liver 46.75 1 1 50 0 1e+00 LOC103694460
Mg content in liver 13.38 1 0 0 0 1e+00 LOC103694460
Na content in liver 13.35 1 0 0 0 1e+00 LOC103694460
Rb content in liver 81.33 1 1 50 0 1e+00 LOC103694460
Se content in liver 9.04 1 0 0 0 1e+00 LOC103694460
Sr content in liver 22.24 1 0 0 0 1e+00 LOC103694460
Zn content in liver 5.66 1 0 0 0 1e+00 LOC103694460

Associations by panel

Tissue RNA modality # hits % hits/tests Avg chisq
Adipose alternative polyA 0 0 1.35
Adipose alternative TSS 0 0 1.31
Adipose gene expression 1 0 1.41
Adipose isoform ratio 0 0 1.34
Adipose intron excision ratio 0 0 1.37
Adipose mRNA stability 0 0 1.41
BLA alternative polyA 0 0 1.43
BLA alternative TSS 0 0 1.4
BLA gene expression 0 0 1.39
BLA isoform ratio 0 0 1.46
BLA intron excision ratio 0 0 1.39
BLA mRNA stability 0 0 1.42
Brain alternative polyA 0 0 1.32
Brain alternative TSS 0 0 1.53
Brain gene expression 0 0 1.41
Brain isoform ratio 0 0 1.44
Brain intron excision ratio 0 0 1.38
Brain mRNA stability 0 0 1.4
Eye alternative polyA 0 0 1.53
Eye alternative TSS 0 0 1.46
Eye gene expression 0 0 1.49
Eye isoform ratio 0 0 1.45
Eye intron excision ratio 0 0 1.29
Eye mRNA stability 0 0 1.39
IL alternative polyA 0 0 1.43
IL alternative TSS 0 0 1.26
IL gene expression 0 0 1.37
IL isoform ratio 0 0 1.47
IL intron excision ratio 0 0 1.31
IL mRNA stability 0 0 1.38
LHb alternative polyA 0 0 1.43
LHb alternative TSS 0 0 1.16
LHb gene expression 0 0 1.46
LHb isoform ratio 0 0 1.33
LHb intron excision ratio 0 0 1.38
LHb mRNA stability 0 0 1.44
Liver alternative polyA 0 0 1.39
Liver alternative TSS 0 0 1.43
Liver gene expression 0 0 1.37
Liver isoform ratio 0 0 1.34
Liver intron excision ratio 0 0 1.34
Liver mRNA stability 0 0 1.38
NAcc alternative polyA 0 0 1.37
NAcc alternative TSS 0 0 1.42
NAcc gene expression 0 0 1.45
NAcc isoform ratio 0 0 1.35
NAcc intron excision ratio 0 0 1.38
NAcc mRNA stability 0 0 1.41
OFC alternative polyA 0 0 1.46
OFC alternative TSS 0 0 1.39
OFC gene expression 0 0 1.4
OFC isoform ratio 0 0 1.34
OFC intron excision ratio 0 0 1.39
OFC mRNA stability 0 0 1.44
PL alternative polyA 0 0 1.33
PL alternative TSS 0 0 1.42
PL gene expression 0 0 1.4
PL isoform ratio 0 0 1.41
PL intron excision ratio 1 0 1.41
PL mRNA stability 0 0 1.38
pVTA alternative polyA 0 0 1.4
pVTA alternative TSS 0 0 1.52
pVTA gene expression 0 0 1.42
pVTA isoform ratio 0 0 1.35
pVTA intron excision ratio 0 0 1.39
pVTA mRNA stability 0 0 1.45
RMTg alternative polyA 0 0 1.36
RMTg alternative TSS 0 0 1.47
RMTg gene expression 0 0 1.4
RMTg isoform ratio 0 0 1.42
RMTg intron excision ratio 0 0 1.28
RMTg mRNA stability 0 0 1.44