Hub : Genes

Arhgef39

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	Arhgef39	0.02	0.02	4.7e-03	0.01	0	0	0	4.2e-02	2.7e-01	2.4e-01	2.3e-01
2	NAcc	gene expression	Arhgef39	0.04	0.03	1.8e-05	0.03	0.04	0.04	0.04	9.9e-05	1.2e-05	3.3e-05	2.5e-05
3	BLA	gene expression	Arhgef39	0.09	0.06	4.1e-05	0.07	0.09	0.08	0.08	2.1e-04	2.2e-05	5.4e-05	5.8e-05
4	Adipose	gene expression	Arhgef39	0.06	0.04	1.8e-04	0.03	0.03	0.03	0.03	2.9e-04	2.2e-04	8.1e-04	4.9e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	1.1	1.9	2.6	-1.2	1.6	1.6	1.0
Area under the delay curve	0.6	0.6	1.1	0.5	-0.8	-0.8	-1.0
BMI with tail	2.3	7.6	10.1	-2.5	3.1	3.2	2.1
BMI without tail	5.1	10.5	14.4	-3.6	3.8	3.7	0.7
Body weight	3.2	13.5	17.8	-4.2	4.2	4.2	1.1
Weight adjusted by age	0.5	0.5	1.1	-0.9	0.3	0.3	-1.0
Bone surface	0.6	1.0	1.4	-1.1	1.2	1.2	-0.0
Bone volume	0.5	0.9	1.4	-0.9	1.2	1.2	0.4
Breakpoint value in progressive ratio session	1.0	1.1	3.5	-0.2	-0.6	-0.6	-1.9
Number of licking bursts	4.2	4.9	6.4	-2.3	2.5	2.5	1.3
Context. condit. distance diff. score	0.1	0.1	0.2	0.4	-0.3	-0.2	0.3
Locomotion velocity, session 1	2.2	2.4	8.0	-1.2	0.4	0.3	-2.8
Locomotion distance, session 1	0.7	0.9	2.4	-0.9	0.4	0.4	-1.5
Locomotion velocity, session 2	2.5	3.0	3.5	-1.8	1.9	1.9	1.3
Locomotion distance, session 2	1.7	2.3	3.9	-2.0	1.6	1.5	-0.9
Locomotion velocity, session 3	0.5	0.6	2.1	-0.3	0.0	-0.0	-1.4
Locomotion distance, session 3	2.1	2.3	3.3	-1.8	1.7	1.7	-0.3
Stereotopy head waving bouts, day 3	0.8	0.9	3.0	0.1	-0.5	-0.6	-1.7
Stereotopy head waving duration, day 3	0.6	0.7	1.4	0.5	-0.8	-0.8	-1.2
Locomotion velocity, session 7	0.1	0.1	0.1	0.3	-0.3	-0.2	-0.0
Locomotion distance, session 7	0.2	0.2	0.3	-0.4	0.5	0.5	-0.2
Stereotopy head waving bouts, day 7	2.0	2.3	3.3	-1.8	1.7	1.7	0.0
Stereotopy head waving duration, day 7	0.5	0.6	0.9	-1.0	0.8	0.8	-0.4
Locomotion velocity, session 8	0.4	0.5	1.9	-0.3	-0.1	-0.2	-1.4
Locomotion distance, session 8	0.3	0.4	1.1	-0.7	0.4	0.3	-1.0
Degree of sensitization distance	1.1	1.1	1.7	1.3	-1.2	-1.2	-0.1
Degree of sensitization stereotypy	1.3	1.4	1.9	-1.3	1.3	1.4	0.3
Conditioned locomotion	0.3	0.4	1.4	-0.1	-0.2	-0.2	-1.2
Cocaine response after cond. corrected	2.5	2.8	4.3	1.4	-1.6	-1.6	-2.1
Cocaine response after cond. not corrected	2.5	2.8	5.5	1.1	-1.4	-1.5	-2.3
Cocaine response before conditioning	0.6	0.8	1.1	-1.1	1.0	0.9	0.3
Saline control response	0.8	1.1	1.4	-1.2	0.9	0.8	-1.2
Bone: connectivity density	0.7	1.1	1.4	-0.8	1.1	1.2	1.0
Bone: cortical apparent density	0.6	0.7	2.6	0.6	-0.1	-0.1	1.6
Bone: cortical area	2.1	3.2	4.0	-1.7	2.0	2.0	1.4
Bone: cortical porosity	0.3	0.4	0.5	0.6	-0.7	-0.7	-0.2
Bone: cortical porosity	0.0	0.0	0.0	-0.1	0.0	0.0	-0.0
Bone: cortical thickness	1.0	1.7	3.1	-0.7	1.2	1.3	1.8
Bone: cortical thickness	0.2	0.2	0.4	0.7	-0.3	-0.3	0.4
Bone: cortical tissue density	0.5	0.7	2.1	0.7	-0.2	-0.2	1.5
Condit. Reinf. active minus inactive responses	0.6	0.6	0.9	-0.9	0.8	0.8	0.6
Condit. Reinf. active-inactive response ratio	0.5	0.6	0.8	0.9	-0.8	-0.8	0.1
Condit. Reinf. active responses	2.9	3.5	4.6	-2.2	2.1	2.0	1.1
Condit. Reinf. inactive responses	3.4	4.1	5.0	-2.1	2.2	2.2	1.4
Incentive salience index mean	4.2	5.1	7.5	-2.7	2.5	2.5	0.7
Condit. Reinf. lever presses	9.6	12.8	19.4	-4.4	4.0	4.0	0.3
Condit. Reinf. active minus inactive responses	0.7	0.8	1.1	-0.9	1.0	1.0	0.6
Condit. Reinf. active-inactive response ratio	0.2	0.3	0.6	-0.2	0.4	0.5	0.8
Condit. Reinf. active responses	2.1	2.9	3.8	-1.9	1.9	1.9	0.7
Condit. Reinf. inactive responses	2.8	3.5	4.3	-2.0	2.1	2.0	1.1
Condit. Reinf. lever presses	2.5	3.4	3.8	-1.7	2.0	2.0	1.7
Condit. Reinf. lever reinforcers received	2.4	3.4	4.4	-2.1	2.1	2.1	0.8
Conditioned reinforcement - actives	0.3	0.3	0.3	-0.5	0.5	0.6	0.6
Conditioned reinforcement - inactives	0.0	0.0	0.1	0.1	-0.3	-0.2	-0.2
Conditioned locomotion	0.4	0.5	0.7	-0.9	0.6	0.8	0.4
Patch foraging indifference point 0 sec	1.0	1.6	4.1	-1.3	0.6	0.7	-2.0
Patch foraging indifference point AUC	7.7	8.8	11.7	-3.4	3.4	3.4	0.6
Delay disc. indifference point, 0s delay	1.4	1.5	1.8	1.1	-1.3	-1.3	-1.2
Delay disc. indifference point, 16s delay	1.7	1.7	3.3	0.8	-1.2	-1.2	-1.8
Delay disc. indifference point, 2s delay	0.1	0.1	0.4	0.2	0.2	0.2	0.6
Delay disc. indifference point, 24s delay	0.2	0.2	0.2	0.5	-0.4	-0.4	-0.2
Delay disc. indifference point, 4s delay	0.1	0.1	0.2	0.4	-0.3	-0.3	-0.2
Delay disc. indifference point, 8s delay	0.0	0.0	0.1	-0.3	0.1	0.1	-0.2
Indifference point function ln k	2.4	3.4	4.5	2.0	-2.1	-2.1	-0.7
Indifference point function log k	2.4	3.4	4.5	2.0	-2.1	-2.1	-0.7
Patch foraging total patch changes 0 sec	1.2	1.9	2.8	-1.6	1.0	1.1	-1.7
Patch foraging total patch changes 12 sec	2.4	3.1	4.2	-1.9	2.0	2.1	0.6
Patch foraging total patch changes 18 sec	0.7	0.9	1.4	-1.2	1.1	1.1	-0.2
Patch foraging total patch changes 24 sec	2.5	3.1	4.3	-2.1	2.0	2.0	-0.2
Patch foraging total patch changes 6 sec	2.9	4.3	6.7	-2.6	2.2	2.3	-0.7
Patch foraging time to switch 0 sec	2.8	4.3	6.3	2.5	-2.3	-2.3	0.3
Patch foraging water rate 0 sec	1.8	2.8	3.9	-2.0	1.8	1.9	-0.5
Patch foraging water rate 12 sec	0.1	0.1	0.5	-0.1	0.1	0.1	-0.7
Patch foraging water rate 18 sec	0.5	0.6	0.8	-0.6	0.8	0.9	0.8
Patch foraging water rate 24 sec	0.4	0.5	1.8	0.3	0.2	0.3	1.3
Patch foraging water rate 6 sec	0.4	0.5	0.9	-0.7	0.9	0.9	-0.0
Seeking ratio, delayed vs. immediate footshock	4.1	4.7	6.9	-2.6	2.3	2.3	1.3
Distance traveled before self-admin	3.7	3.9	5.7	-2.4	2.2	2.2	-0.5
Distance traveled after self-admin	0.4	0.5	0.6	-0.6	0.8	0.7	0.7
Extensor digitorum longus weight	4.4	17.3	24.8	-5.0	4.7	4.6	1.0
Bone: elastic displacement	3.6	4.1	6.0	2.5	-2.3	-2.2	0.5
Bone: elastic work	2.1	2.7	3.9	1.9	-1.3	-1.3	2.0
Bone: endosteal estimation	0.9	1.9	3.2	-1.8	1.5	1.4	-0.7
Bone: endosteal perimeter	1.0	2.1	3.5	-1.9	1.5	1.4	-0.9
Epididymis fat weight	0.4	1.0	1.7	-1.3	1.1	1.0	-0.3
Delta time in closed arm before/after self-admin	3.0	2.9	3.2	-1.5	1.8	1.8	1.7
Delta time in open arm before/after self-admin	0.6	0.6	1.1	0.1	-0.8	-0.8	-1.0
Diff in mean of infusions in LGA sessions	0.0	0.0	0.1	0.3	-0.2	-0.2	0.2
Delay discount exponential model param	0.4	0.5	0.9	-0.4	0.6	0.7	1.0
Extinction: sum of active levers before priming	1.6	1.6	2.4	1.1	-1.5	-1.5	-0.7
Active lever presses in extinction session 6	0.2	0.2	0.3	0.1	-0.6	-0.5	-0.4
Bone: final force	0.9	1.4	2.1	-1.2	1.4	1.4	0.4
Bone: final moment	0.6	1.0	1.5	-1.0	1.2	1.2	0.6
Food consumed during 24 hour testing period	0.7	0.8	1.3	-1.1	1.0	0.9	-0.4
Glucose	1.1	1.6	2.3	-1.5	1.5	1.4	0.2
Heart weight	0.7	1.0	1.9	-1.4	1.0	1.0	-0.3
Delay discount hyperbolic model param	0.4	0.4	0.8	-0.3	0.6	0.6	0.9
Intermittent access intake day 1-15 change	1.0	1.0	2.4	-0.4	0.9	0.9	1.5
Intermittent access intake escalation	1.3	1.3	2.1	-0.7	1.2	1.2	1.4
Intermittent access intake escalation 2	1.8	1.8	4.1	-0.4	1.2	1.2	2.0
Intermitt. access day 1 inactive lever presses	0.6	0.7	0.9	-0.9	0.9	1.0	0.2
Intermitt. access day 15 inactive lever presses	0.1	0.2	0.4	-0.4	0.1	0.1	-0.7
Intermitt. access escalation Index	1.0	0.9	1.3	-1.1	1.0	0.9	-0.6
Intermittent access day 1 total infusions	0.4	0.5	1.3	-0.0	-0.6	-0.5	-1.1
Intermittent access day 15 total infusions	0.6	0.7	1.0	-1.0	0.8	0.9	0.5
Intermittent access terminal intake (last 3 days)	0.7	0.8	1.1	-1.1	0.9	1.0	0.4
Intermittent access total infusions	0.9	1.0	1.7	-1.3	1.0	1.1	0.2
Intermittent access day 1 locomotion	0.5	0.5	0.8	0.2	-0.9	-0.8	-0.9
Intermittent access day 15 total locomotion	0.3	0.3	0.7	0.4	-0.8	-0.7	-0.2
Intermittent access total locomotion	0.2	0.2	0.3	0.3	-0.6	-0.4	0.4
Intermittent access standard deviation	0.5	0.5	0.6	-0.7	0.6	0.7	0.8
Left kidney weight	0.5	1.4	2.6	-1.6	1.1	1.1	-0.8
Right kidney weight	0.1	0.3	0.8	-0.6	0.1	-0.0	-0.9
Cocaine induced anxiety	1.3	1.5	2.0	1.4	-1.3	-1.3	-0.7
Post-drug Anxiety	0.2	0.2	0.3	-0.5	0.5	0.3	-0.4
Baseline Anxiety	1.7	1.8	2.1	-1.4	1.4	1.4	1.1
Tail length	2.3	6.9	11.0	-3.3	2.9	2.8	-0.2
Length with tail	0.9	3.2	6.0	-2.5	1.8	1.7	-0.9
Length without tail	0.3	0.7	1.0	0.6	-1.0	-0.9	-0.6
Times rat made contact with spout	0.4	0.5	0.9	-0.4	0.7	0.7	1.0
Lifetime Intake	0.9	1.0	2.1	-1.5	0.8	0.9	-0.6
Liver weight, left	0.2	0.4	0.6	-0.8	0.7	0.6	-0.2
Liver weight, right	0.2	0.3	0.7	0.1	-0.4	-0.5	-0.8
Locomotor activity	0.0	0.0	0.0	-0.2	0.1	0.0	-0.1
Locomotor testing distance	0.3	0.5	1.7	-0.1	-0.3	-0.3	-1.3
Locomotor testing rearing	0.5	0.8	1.4	-1.2	0.9	0.8	-0.5
Locomotion in novel chamber	0.3	0.3	1.2	0.2	0.1	0.1	1.1
Locomotion in novel chamber post-restriction	2.1	2.5	4.3	-1.0	1.6	1.6	2.1
Fecal boli incidents, locomotor time 1	0.4	0.5	0.7	0.7	-0.8	-0.8	0.3
Change in fecal boli incidents, locomotor task	0.8	0.8	0.9	-1.0	0.9	0.9	-0.7
Time >=10cm from walls, locomotor time 1	0.3	0.3	1.1	-0.2	-0.0	-0.0	-1.0
Bouts of movement, locomotor time 1	1.7	1.9	2.8	1.7	-1.5	-1.5	-0.3
Total resting periods, locomotor time 1	2.2	2.4	4.0	2.0	-1.7	-1.7	0.1
Rest time, locomotor task time 1	2.3	2.6	4.4	2.1	-1.1	-1.2	1.8
Distance moved, locomotor task time 1	2.1	2.3	3.9	-2.0	1.4	1.4	-1.2
Vertical activity count, locomotor time 1	1.8	1.8	3.6	-1.5	0.9	0.8	-1.9
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.2	-0.5	0.3	0.3	-0.3
Bouts of movement, locomotor time 2	0.6	0.6	1.2	-1.1	0.8	0.8	0.2
Total resting periods, locomotor time 2	0.3	0.3	0.5	-0.7	0.5	0.5	0.2
Rest time, locomotor task time 2	1.0	1.1	2.4	1.6	-1.0	-1.0	0.2
Distance moved, locomotor task time 2	0.4	0.5	0.6	-0.5	0.7	0.7	0.8
Vertical activity count, locomotor time 2	0.4	0.5	1.0	-1.0	0.7	0.6	-0.3
Light reinforcement 1	1.7	3.1	7.7	-1.8	0.8	0.7	-2.8
Light reinforcement 2	2.2	3.0	10.2	-1.3	0.2	0.0	-3.2
Bone: marrow area	0.9	2.0	3.3	-1.8	1.6	1.5	-0.4
Bone: maximum diameter	2.0	3.7	4.9	-2.2	2.2	2.1	0.7
Bone: maximum force	2.3	3.9	5.5	-2.1	2.3	2.3	0.9
Bone: maximum moment	1.8	3.1	4.2	-1.8	2.0	2.0	1.0
Mean time between licks in bursts	0.5	0.7	1.1	0.9	-0.9	-1.0	-0.4
Mean num. licks in bursts	1.9	2.3	3.1	1.7	-1.8	-1.7	-0.4
Cd content in liver	0.7	0.7	1.0	-0.5	0.9	0.9	1.0
Co content in liver	1.6	1.8	2.0	1.4	-1.4	-1.4	-1.2
Cu content in liver	1.1	1.4	2.6	1.6	-1.2	-1.2	0.3
Fe content in liver	1.0	1.2	4.2	-0.6	-0.0	-0.1	-2.1
K content in liver	0.5	0.5	0.9	0.5	-0.6	-0.6	-1.0
Mg content in liver	0.4	0.4	0.5	0.7	-0.7	-0.7	-0.4
Mn content in liver	0.4	0.4	1.0	-0.3	0.5	0.5	1.0
Na content in liver	1.7	1.8	2.4	1.5	-1.5	-1.6	-0.7
Rb content in liver	4.3	5.3	7.1	2.7	-2.5	-2.5	-1.2
Se content in liver	1.8	2.2	2.7	-1.7	1.6	1.5	1.2
Sr content in liver	0.7	0.6	1.2	-1.1	0.8	0.7	0.4
Zn content in liver	0.3	0.4	1.2	0.1	0.4	0.4	1.1
Bone: minimum diameter	0.0	0.0	0.2	0.1	-0.1	-0.1	0.4
Time in familiar zone, hab. session 1	1.8	1.7	5.7	1.0	-0.2	-0.1	2.4
Time in novel zone, hab. session 1	3.7	3.7	8.6	0.8	-1.6	-1.7	-2.9
Total zone transitions, hab. session 1	0.0	0.0	0.0	-0.1	0.1	0.1	0.1
Total locomotion distance, hab. session 1	0.7	1.0	2.4	-0.6	0.8	0.8	1.6
Locomotion velocity, hab. session 1	1.8	2.6	2.8	-1.5	1.7	1.6	1.6
Time in familiar zone, hab. session 2	0.9	0.9	1.7	1.0	-0.7	-0.7	1.3
Time in novel zone, hab. session 2	2.1	2.1	4.4	0.9	-1.3	-1.3	-2.1
Total zone transitions, hab. session 2	0.5	0.7	1.0	-1.0	0.8	0.7	-0.7
Total locomotion distance, hab. session 2	0.7	1.0	1.3	-1.2	1.1	1.1	0.4
Locomotion velocity, hab. session 2	1.0	1.4	1.8	-1.3	1.3	1.3	0.6
Novel to familiar place preference ratio	3.7	3.8	4.4	1.6	-2.1	-2.1	-2.0
Novelty place preference	4.7	4.8	5.8	2.0	-2.4	-2.4	-1.9
Time in novel zone, NPP test	5.9	6.0	7.3	2.2	-2.7	-2.7	-2.1
Total zone transitions, NPP test	0.7	1.0	1.5	-1.2	0.9	0.8	-1.0
Total locomotion distance, NPP test	1.7	2.4	3.8	-2.0	1.7	1.6	-0.5
Locomotion velocity, NPP test	2.3	3.2	4.8	-2.2	2.0	2.0	-0.1
Intraocular pressure	2.0	2.8	3.8	-1.9	1.9	1.9	-0.3
Delta distance traveled before/after self-admin	0.7	0.8	1.1	1.0	-1.0	-1.0	0.1
Delta ambulatory time before/after self-admin	1.7	1.9	2.7	1.6	-1.5	-1.6	0.1
Parametrial fat weight	0.2	0.3	0.4	-0.7	0.5	0.4	-0.6
Pavlov. Cond. lever latency	6.6	8.4	11.9	3.4	-3.3	-3.3	-0.5
Pavlov. Cond. magazine entry latency	0.4	0.5	0.7	-0.8	0.8	0.7	0.4
Pavlov. Cond. change in total contacts	2.4	2.6	3.8	-1.9	1.8	1.8	0.2
Pavlov. Cond. index score	2.9	3.7	5.0	-2.2	2.2	2.1	0.8
Pavlov. Cond. latency score	2.7	3.5	4.7	-2.2	2.1	2.1	0.7
Pavlov. Cond. lever contacts	5.1	6.0	8.0	-2.8	2.8	2.8	0.7
Pavlov. Cond. magazine entry number	0.7	0.9	1.1	1.1	-1.0	-1.0	-0.5
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.4	-0.6	0.6	0.6	0.3
Pavlov. Cond. lever-magazine prob. diff.	2.8	3.5	4.4	-2.1	2.1	2.1	1.1
Pavlov. Cond. response bias	2.9	3.5	4.9	-2.2	2.1	2.1	0.6
Pavlov. Cond. lever latency	2.8	3.8	4.4	1.9	-2.1	-2.1	-1.8
Pavlov. Cond. magazine entry latency	0.4	0.5	0.7	0.8	-0.8	-0.8	0.1
Pavlov. Cond. change in total contacts	1.2	1.6	3.9	-0.6	1.1	1.0	2.0
Pavlov. Cond. index score	0.4	0.5	1.6	-0.3	0.5	0.5	1.3
Pavlov. Cond. latency score	0.7	0.8	2.2	-0.4	0.7	0.7	1.5
Pavlov. Cond. lever contacts	1.5	2.0	2.3	-1.4	1.5	1.5	1.2
Pavlov. Cond. magazine entry number	0.4	0.5	2.0	-0.2	-0.1	-0.1	-1.4
Pavlov. Cond. intertrial magazine entries	0.4	0.5	0.8	-0.8	0.8	0.9	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.6	1.8	-0.2	0.5	0.4	1.3
Pavlov. Cond. response bias	0.6	0.9	1.2	-0.8	0.9	0.9	1.1
Time in closed arm before self-admin	2.2	2.5	3.7	1.9	-1.8	-1.7	-0.4
Time in closed arm after self-admin	0.3	0.3	0.5	0.7	-0.3	-0.2	0.7
Time in open arm before self-admin	2.1	2.3	3.9	-2.0	1.6	1.5	-0.6
Time in open arm after self-admin	1.5	1.7	3.6	-1.9	1.2	1.2	-0.7
Bone: periosteal estimation	1.3	2.6	3.7	-1.9	1.9	1.8	0.2
Bone: periosteal perimeter	0.5	0.8	1.4	-1.2	0.9	0.8	-0.7
Bone: post-yield work	1.2	1.6	2.6	-1.6	1.4	1.3	-0.6
Progressive ratio test 1 active lever presses	0.4	0.4	0.8	-0.9	0.3	0.5	-0.7
Progressive ratio test 1 breakpoint	0.5	0.5	1.0	-1.0	0.5	0.6	-0.7
Progressive ratio test 1 inactive lever presses	1.0	1.0	2.7	-1.1	0.4	0.5	-1.6
Progressive ratio test 2 active lever presses	0.4	0.4	1.2	-0.6	-0.2	-0.0	-1.1
Progressive ratio test 2 breakpoint	0.3	0.4	1.2	-0.4	-0.4	-0.2	-1.1
Progressive ratio test 2 inactive lever presses	0.2	0.2	0.5	-0.7	0.4	0.5	-0.1
Incentive Sensitization - Responses	0.1	0.1	0.5	-0.1	-0.2	-0.2	-0.7
Incentive Sensitization - Breakpoint	0.2	0.2	0.5	-0.0	-0.4	-0.3	-0.7
Sum of active levers in priming session hrs 5-6	2.9	2.8	3.7	1.4	-1.9	-1.9	-1.4
Progressive ratio	0.0	0.0	0.1	-0.1	-0.2	-0.1	-0.2
Food seeking constrained by brief footshock	6.9	8.4	14.2	-3.8	3.1	3.1	-0.6
Seeking ratio, punishment vs. effort	1.6	2.0	2.8	-1.7	1.6	1.6	-0.0
Retroperitoneal fat weight	0.1	0.2	0.3	0.5	-0.5	-0.6	0.3
Reaction time number correct	0.1	0.2	0.3	-0.4	0.3	0.3	-0.5
Reaction time mean minus median	1.5	2.0	6.5	-0.4	0.9	0.9	2.5
Reaction time mean minus median AUC	1.7	2.2	4.4	-1.0	1.3	1.3	2.1
Reaction time num false alarms	0.1	0.2	0.6	-0.3	0.2	0.2	0.8
Reaction time num false alarms AUC	0.4	0.6	1.0	-1.0	0.7	0.7	0.4
Reaction time trials correct on left	0.1	0.2	0.3	-0.4	0.3	0.3	-0.5
Reaction time trials on left	0.1	0.1	0.3	-0.3	0.2	0.2	-0.5
Reaction time mean	1.4	2.0	3.0	1.7	-1.2	-1.2	1.5
Reaction time mean AUC	1.6	2.2	3.2	1.8	-1.3	-1.3	1.5
Median of all reaction times	2.6	3.6	5.8	2.4	-2.0	-2.0	0.6
Reaction time omissions	1.2	1.7	2.4	1.4	-1.5	-1.5	-0.1
Reaction time false alarm rate	0.1	0.1	0.4	-0.1	-0.0	-0.0	0.7
Reaction time premature initiation rate	2.1	2.7	4.8	2.2	-1.7	-1.6	0.7
Reaction time premature initiations	1.2	1.7	3.0	1.7	-1.4	-1.3	0.4
Std. dev. reaction times	0.8	1.2	4.4	0.5	-0.0	-0.1	2.1
Reaction time trials completed	0.1	0.1	0.3	-0.3	0.2	0.2	-0.5
Reaction time trials AUC	0.1	0.1	0.2	-0.3	0.2	0.2	-0.5
Run reversals in cocaine runway, females	0.3	0.3	1.0	0.2	0.3	0.3	1.0
Run reversals in cocaine runway, males	0.0	0.0	0.1	0.0	-0.1	-0.0	0.3
Latency to leave start box in cocaine runway	0.6	0.7	0.9	-0.7	0.9	0.9	0.7
Latency to leave start box in cocaine runway, F	0.0	0.0	0.0	0.0	-0.1	-0.0	-0.1
Latency to leave start box in cocaine runway, M	1.0	1.0	1.4	-1.2	1.2	1.1	-0.2
Std. dev. time between licks in bursts	0.3	0.4	0.6	0.7	-0.7	-0.8	-0.2
Total sessions with >9 infusions	0.8	0.9	2.8	-0.7	-0.2	-0.1	-1.7
Short access day 1 total inactive lever presses	1.6	1.8	2.6	-1.6	1.4	1.5	-0.2
Short access day 10 total inactive lever presses	0.1	0.1	0.2	-0.2	0.5	0.4	0.1
Short access day 1 total infusions	1.4	1.4	2.3	-1.5	0.8	0.9	-1.4
Short access day 10 total infusions	0.7	0.8	1.3	-1.1	0.6	0.7	-1.1
Short access total infusions	0.7	0.8	2.3	-0.9	0.2	0.3	-1.5
Short access day 1 locomotion	0.2	0.2	0.6	-0.2	-0.4	-0.4	-0.8
Short access day 10 total locomotion	0.4	0.4	0.6	0.6	-0.7	-0.7	0.6
Short access total locomotion	0.2	0.2	0.5	-0.5	0.1	0.1	-0.7
One hour access (0.3 mA shock)	0.6	0.7	1.5	-1.2	0.8	0.8	-0.4
Compulsive drug intake	0.4	0.4	0.8	-0.9	0.7	0.6	0.1
One hour access (shock baseline)	0.4	0.5	1.0	-1.0	0.5	0.6	-0.6
Social response proportion	2.3	2.5	4.0	2.0	-1.7	-1.8	0.3
Social responses	0.5	0.6	0.9	-1.0	0.9	0.8	0.3
Social time	0.3	0.3	0.5	0.4	-0.5	-0.7	-0.6
Soleus weight	0.9	2.5	9.3	-0.4	-0.5	-0.7	-3.1
Bone: stiffness	3.0	4.7	6.6	-2.4	2.6	2.4	0.8
Tibialis anterior weight	6.0	20.6	30.5	-5.5	5.1	5.0	0.1
Time to tail flick, vehicle, before self-admin	1.0	1.0	1.6	1.3	-1.2	-1.1	0.0
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.0	0.0	-0.1	-0.0	-0.2
Time to tail flick, test, before self-admin	0.3	0.3	0.4	-0.4	0.6	0.7	0.6
Time to tail flick, test, after self-admin	1.1	1.1	2.1	-0.5	1.0	1.1	1.4
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.2	-0.4	0.4	0.4	-0.0
Delta time to tail flick, test, before/after SA	0.1	0.1	0.1	0.3	-0.2	-0.2	0.3
Tibia length	0.4	1.2	4.3	0.0	-0.3	-0.5	-2.1
Ambulatory time before self-admin	3.0	3.2	5.1	-2.3	1.9	1.8	-0.8
Ambulatory time after self-admin	0.1	0.1	0.3	-0.5	0.3	0.3	-0.2
Bone: tissue strength	0.0	0.0	0.1	-0.1	0.2	0.1	0.2
Total heroin consumption	0.7	0.9	2.2	0.3	-0.8	-0.8	-1.5
Bone: trabecular number	1.2	1.9	2.4	-1.2	1.5	1.6	1.2
Bone: trabecular spacing	0.1	0.2	0.6	0.2	-0.0	0.0	0.8
Bone: trabecular thickness	0.0	0.1	0.1	0.3	-0.3	-0.2	0.2
Bone: trabecular tissue density	2.0	2.8	4.6	-2.1	1.9	1.7	0.2
Water consumed over 24 hours	0.7	0.8	1.2	-0.9	1.0	1.1	0.6
Number of responses in last shaping day	1.1	1.2	4.3	-0.7	-0.0	-0.0	-2.1