Best TWAS P=9.73e-10 · Best GWAS P=2.41e-08 conditioned to NaN
| Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adipose | Brca2 | alternative polyA | XM_039089544.1 | 0.03 | 1 | 0.02 | 2.4e-03 | -5.34 | 9.40e-08 | 0.09 | FALSE |
| Adipose | Elavl1 | alternative TSS | XM_039089620.1 | 0.24 | 2417 | 0.11 | 7.3e-12 | -5.52 | 3.46e-08 | 0.24 | FALSE |
| Adipose | Elavl1 | alternative TSS | XM_039089620.1 | 0.17 | 2417 | 0.07 | 1.7e-08 | -5.46 | 4.65e-08 | 0.24 | FALSE |
| Adipose | Elavl1 | alternative TSS | XM_039089621.1 | 0.15 | 2417 | 0.07 | 7.6e-08 | 5.46 | 4.79e-08 | 0.24 | FALSE |
| Adipose | LOC102552452 | alternative TSS | XR_005491757.1 | 0.03 | 24 | 0.01 | 1.7e-02 | -5.2 | 1.99e-07 | 0.54 | FALSE |
| Adipose | LOC120095871 | alternative TSS | XM_039089913.1 | 0.05 | 15 | 0.03 | 8.1e-04 | 5.41 | 6.35e-08 | 0.29 | FALSE |
| Adipose | LOC120095871 | alternative TSS | XM_039089914.1 | 0.05 | 18 | 0.02 | 1.1e-03 | -5.43 | 5.69e-08 | 0.29 | FALSE |
| Adipose | Snapc2 | alternative TSS | NM_001415804.1 | 0.04 | 53 | 0.02 | 6.3e-03 | 5.23 | 1.70e-07 | 0.51 | TRUE |
| Adipose | Stard13 | alternative TSS | XM_039089673.1 | 0.03 | 1441 | 0.02 | 6.6e-03 | -5.54 | 3.03e-08 | 0.41 | FALSE |
| Adipose | Stard13 | alternative TSS | XM_006248749.4 | 0.03 | 1441 | 0.02 | 4.3e-03 | -5.27 | 1.37e-07 | 0.38 | FALSE |
| Adipose | Stard13 | alternative TSS | XM_039089673.1 | 0.04 | 1441 | 0.02 | 1.6e-03 | -5.52 | 3.44e-08 | 0.52 | FALSE |
| Adipose | LOC102549089 | gene expression | LOC102549089 | 0.12 | 19 | 0.05 | 1.9e-06 | -5.66 | 1.53e-08 | 0.86 | FALSE |
| Adipose | Map2k7 | gene expression | Map2k7 | 0.06 | 2244 | 0.03 | 2.3e-04 | -5.59 | 2.30e-08 | 0.46 | FALSE |
| Adipose | N4bp2l1 | gene expression | N4bp2l1 | 0.36 | 19 | 0.28 | 1.1e-31 | 5.41 | 6.29e-08 | 0.93 | FALSE |
| Adipose | Trappc5 | gene expression | Trappc5 | 0.08 | 62 | 0.04 | 9.4e-06 | 6.11 | 9.73e-10 | 0.68 | TRUE |
| Adipose | Xab2 | gene expression | Xab2 | 0.13 | 35 | 0.05 | 5.7e-06 | 5.22 | 1.78e-07 | 0.46 | FALSE |
| Adipose | Elavl1 | isoform ratio | NM_001108848.1 | 0.14 | 2417 | 0.04 | 1.9e-05 | 5.31 | 1.09e-07 | 0.19 | FALSE |
| Adipose | Elavl1 | isoform ratio | XM_039089620.1 | 0.26 | 219 | 0.12 | 4.8e-13 | 5.5 | 3.79e-08 | 0.24 | FALSE |
| Adipose | Elavl1 | mRNA stability | Elavl1 | 0.27 | 130 | 0.12 | 6.3e-13 | -5.72 | 1.08e-08 | 0.24 | FALSE |
| Adipose | N4bp2l1 | mRNA stability | N4bp2l1 | 0.05 | 597 | 0.03 | 1.6e-04 | 5.45 | 5.08e-08 | 0.74 | FALSE |
| BLA | N4bp2l2 | alternative polyA | XM_039089150.1 | 0.06 | 702 | 0.04 | 3.0e-03 | 5.44 | 5.41e-08 | 0.56 | FALSE |
| BLA | Stxbp2 | alternative polyA | XM_039089805.1 | 0.15 | 1833 | 0.04 | 2.2e-03 | -5.42 | 6.01e-08 | 0.54 | FALSE |
| BLA | N4bp2l2 | gene expression | N4bp2l2 | 0.08 | 1 | 0.05 | 1.6e-03 | -5.37 | 7.68e-08 | 0.09 | FALSE |
| BLA | Snapc2 | gene expression | Snapc2 | 0.16 | 15 | 0.06 | 3.7e-04 | 5.97 | 2.34e-09 | 0.41 | FALSE |
| BLA | Stxbp2 | gene expression | Stxbp2 | 0.13 | 1 | 0.07 | 1.1e-04 | 5.3 | 1.17e-07 | 0.18 | FALSE |
| BLA | N4bp2l2 | isoform ratio | XM_039089150.1 | 0.06 | 702 | 0.05 | 9.4e-04 | 5.33 | 9.97e-08 | 0.56 | FALSE |
| BLA | Snapc2 | isoform ratio | XM_039089313.1 | 0.15 | 2285 | 0.04 | 5.8e-03 | 5.69 | 1.24e-08 | 0.52 | FALSE |
| BLA | Stard13 | isoform ratio | XM_039089671.1 | 0.08 | 1 | 0.04 | 2.5e-03 | 5.21 | 1.88e-07 | 0.11 | FALSE |
| BLA | Pet100 | intron excision ratio | chr12_1680794_1680963 | 0.34 | 21 | 0.2 | 3.9e-11 | -5.69 | 1.24e-08 | 0.81 | FALSE |
| BLA | Pet100 | intron excision ratio | chr12_1680995_1681508 | 0.33 | 1836 | 0.2 | 1.0e-10 | 5.38 | 7.64e-08 | 0.8 | FALSE |
| Brain | Stxbp2 | alternative polyA | XM_039089804.1 | 0.09 | 1 | 0.07 | 1.0e-06 | -5.19 | 2.09e-07 | 0.59 | FALSE |
| Brain | Stxbp2 | alternative polyA | XM_039089805.1 | 0.13 | 1 | 0.12 | 4.9e-11 | 5.19 | 2.09e-07 | 0.61 | FALSE |
| Brain | Arhgef18 | alternative TSS | NM_001395655.1 | 0.09 | 9 | 0.05 | 3.3e-05 | -5.29 | 1.20e-07 | 0.28 | FALSE |
| Brain | Arhgef18 | alternative TSS | XM_039089307.1 | 0.1 | 11 | 0.05 | 4.3e-05 | 5.25 | 1.50e-07 | 0.23 | FALSE |
| Brain | Insr | alternative TSS | XM_039089098.1 | 0.34 | 48 | 0.2 | 2.4e-18 | -5.77 | 7.87e-09 | 0.86 | FALSE |
| Brain | Insr | alternative TSS | XM_039089097.1 | 0.33 | 103 | 0.2 | 7.0e-18 | 5.5 | 3.71e-08 | 0.86 | FALSE |
| Brain | Insr | alternative TSS | XM_039089098.1 | 0.34 | 48 | 0.2 | 3.5e-18 | -5.78 | 7.53e-09 | 0.86 | FALSE |
| Brain | Pcp2 | alternative TSS | XM_008768953.3 | 0.13 | 17 | 0.09 | 4.8e-09 | 5.26 | 1.47e-07 | 0.7 | FALSE |
| Brain | Snapc2 | alternative TSS | NM_001415804.1 | 0.22 | 1 | 0.19 | 1.1e-17 | 5.19 | 2.15e-07 | 0.79 | FALSE |
| Brain | Snapc2 | alternative TSS | XM_039089313.1 | 0.79 | 1 | 0.28 | 7.5e-26 | -5.19 | 2.15e-07 | 0.79 | FALSE |
| Brain | Snapc2 | alternative TSS | NM_001415804.1 | 0.24 | 1 | 0.2 | 1.1e-18 | 5.19 | 2.15e-07 | 0.79 | FALSE |
| Brain | Snapc2 | alternative TSS | XM_039089313.1 | 0.71 | 1 | 0.24 | 4.0e-22 | -5.19 | 2.15e-07 | 0.79 | FALSE |
| Brain | Elavl1 | gene expression | Elavl1 | 0.1 | 2419 | 0.05 | 2.7e-05 | -5.59 | 2.25e-08 | 0.32 | FALSE |
| Brain | Pcp2 | gene expression | Pcp2 | 0.11 | 1 | 0.08 | 3.0e-08 | -5.29 | 1.20e-07 | 0.73 | FALSE |
| Brain | Arhgef18 | isoform ratio | NM_001395655.1 | 0.08 | 11 | 0.06 | 1.1e-06 | -5.63 | 1.78e-08 | 0.62 | FALSE |
| Brain | Arhgef18 | isoform ratio | XM_039089307.1 | 0.07 | 25 | 0.06 | 3.7e-06 | 5.49 | 3.92e-08 | 0.53 | FALSE |
| Brain | Insr | isoform ratio | XM_039089096.1 | 0.23 | 1 | 0.16 | 1.5e-14 | 5.42 | 6.13e-08 | 0.83 | FALSE |
| Brain | Insr | isoform ratio | XM_039089097.1 | 0.09 | 1555 | 0.06 | 1.8e-06 | 5.59 | 2.31e-08 | 0.56 | FALSE |
| Brain | Pex11g | isoform ratio | NM_001105902.1 | 0.04 | 1 | 0.04 | 1.7e-04 | -5.2 | 2.03e-07 | 0.35 | FALSE |
| Brain | Snapc2 | isoform ratio | NM_001415804.1 | 0.23 | 1 | 0.2 | 2.2e-18 | 5.19 | 2.15e-07 | 0.79 | FALSE |
| Brain | Snapc2 | isoform ratio | XM_039089313.1 | 0.36 | 1 | 0.25 | 7.3e-23 | -5.19 | 2.15e-07 | 0.79 | FALSE |
| Brain | Pet100 | intron excision ratio | chr12_1680794_1680963 | 0.07 | 1 | 0.04 | 1.4e-04 | 5.34 | 9.20e-08 | 0.47 | FALSE |
| Brain | Pet100 | intron excision ratio | chr12_1680995_1681508 | 0.06 | 1 | 0.03 | 5.9e-04 | -5.34 | 9.20e-08 | 0.31 | FALSE |
| Brain | Elavl1 | mRNA stability | Elavl1 | 0.14 | 12 | 0.07 | 5.1e-07 | 5.63 | 1.83e-08 | 0.5 | FALSE |
| Brain | Insr | mRNA stability | Insr | 0.76 | 157 | 0.6 | 1.5e-69 | -5.44 | 5.41e-08 | 0.82 | FALSE |
| Eye | Stxbp2 | alternative polyA | XM_039089804.1 | 0.64 | 50 | 0.28 | 3.5e-05 | 5.36 | 8.35e-08 | 0.42 | FALSE |
| Eye | Elavl1 | intron excision ratio | chr12_2667464_2684652 | 0.69 | 8 | 0.37 | 1.3e-06 | 5.37 | 8.08e-08 | 0.29 | FALSE |
| Eye | LOC120095871 | intron excision ratio | chr12_3871255_3873703 | 0.33 | 132 | 0.09 | 1.8e-02 | -5.68 | 1.36e-08 | 0.39 | FALSE |
| Eye | Insr | mRNA stability | Insr | 0.82 | 1 | 0.26 | 6.5e-05 | -5.32 | 1.02e-07 | 0.07 | FALSE |
| IL | LOC102552452 | gene expression | LOC102552452 | 0.51 | 100 | 0.32 | 2.3e-08 | -5.84 | 5.35e-09 | 0.64 | FALSE |
| LHb | Insr | intron excision ratio | chr12_1257822_1307450 | 0.71 | 407 | 0.34 | 5.1e-09 | -5.63 | 1.85e-08 | 0.66 | FALSE |
| LHb | Brca2 | mRNA stability | Brca2 | 0.29 | 435 | 0.12 | 7.5e-04 | 5.28 | 1.29e-07 | 0.65 | FALSE |
| Liver | Stxbp2 | alternative polyA | XM_006248783.4 | 0.07 | 39 | 0.06 | 2.8e-07 | 5.44 | 5.39e-08 | 0 | FALSE |
| Liver | Stxbp2 | alternative polyA | XM_039089804.1 | 0.42 | 31 | 0.28 | 2.4e-31 | -5.52 | 3.32e-08 | 0.7 | FALSE |
| Liver | Stxbp2 | alternative polyA | NM_031126.1 | 0.07 | 32 | 0.06 | 2.5e-07 | -5.24 | 1.58e-07 | 0 | FALSE |
| Liver | Brca2 | gene expression | Brca2 | 0.04 | 1 | 0.03 | 4.3e-04 | -5.34 | 9.40e-08 | 0.23 | FALSE |
| Liver | Cd209a | gene expression | Cd209a | 0.2 | 234 | 0.05 | 4.9e-06 | 5.39 | 6.99e-08 | 0.16 | FALSE |
| Liver | LOC102552452 | gene expression | LOC102552452 | 0.59 | 7 | 0.37 | 1.4e-42 | 5.33 | 9.76e-08 | 0.65 | FALSE |
| Liver | Mcoln1 | gene expression | Mcoln1 | 0.07 | 1 | 0.03 | 1.2e-04 | -5.48 | 4.23e-08 | 0.43 | FALSE |
| Liver | N4bp2l1 | gene expression | N4bp2l1 | 0.2 | 88 | 0.16 | 4.6e-17 | 5.32 | 1.04e-07 | 0.65 | FALSE |
| Liver | Pex11g | isoform ratio | XM_017598285.2 | 0.06 | 1 | 0.03 | 2.9e-04 | -5.29 | 1.25e-07 | 0.23 | FALSE |
| Liver | Insr | intron excision ratio | chr12_1257822_1307450 | 0.4 | 1 | 0.19 | 6.8e-21 | -5.38 | 7.44e-08 | 0.8 | FALSE |
| Liver | Pet100 | intron excision ratio | chr12_1680794_1680963 | 0.2 | 76 | 0.1 | 4.0e-11 | 5.56 | 2.65e-08 | 0.73 | FALSE |
| Liver | Pet100 | intron excision ratio | chr12_1680995_1681508 | 0.18 | 19 | 0.07 | 2.4e-08 | 5.55 | 2.90e-08 | 0.53 | FALSE |
| Liver | Brca2 | mRNA stability | Brca2 | 0.18 | 431 | 0.13 | 2.3e-14 | 5.51 | 3.60e-08 | 0.89 | FALSE |
| Liver | Elavl1 | mRNA stability | Elavl1 | 0.08 | 2417 | 0.04 | 4.1e-05 | 5.53 | 3.25e-08 | 0.37 | FALSE |
| Liver | Pet100 | mRNA stability | Pet100 | 0.5 | 1831 | 0.31 | 3.8e-35 | 5.91 | 3.42e-09 | 0.83 | FALSE |
| NAcc | N4bp2l2 | alternative polyA | XM_039089150.1 | 0.03 | 1 | 0.02 | 1.4e-03 | -5.36 | 8.45e-08 | 0.12 | FALSE |
| NAcc | Snapc2 | alternative TSS | NM_001415804.1 | 0.09 | 2285 | 0.06 | 5.2e-07 | -5.52 | 3.39e-08 | 0.59 | FALSE |
| NAcc | Snapc2 | alternative TSS | XM_039089313.1 | 0.07 | 2285 | 0.03 | 6.7e-04 | 5.43 | 5.58e-08 | 0.42 | FALSE |
| NAcc | Snapc2 | alternative TSS | NM_001415804.1 | 0.08 | 2285 | 0.04 | 6.5e-06 | -5.53 | 3.13e-08 | 0.59 | FALSE |
| NAcc | Snapc2 | alternative TSS | XM_039089313.1 | 0.07 | 16 | 0.03 | 2.4e-04 | -5.32 | 1.01e-07 | 0.32 | FALSE |
| NAcc | Arhgef18 | gene expression | Arhgef18 | 0.09 | 1543 | 0.04 | 2.3e-05 | -5.59 | 2.26e-08 | 0.58 | FALSE |
| NAcc | Cers4 | gene expression | Cers4 | 0.39 | 56 | 0.41 | 1.3e-51 | -5.86 | 4.73e-09 | 0.59 | FALSE |
| NAcc | Snapc2 | gene expression | Snapc2 | 0.15 | 1 | 0.07 | 1.1e-08 | 5.43 | 5.77e-08 | 0.93 | FALSE |
| NAcc | Stxbp2 | gene expression | Stxbp2 | 0.1 | 1833 | 0.05 | 7.4e-07 | -5.64 | 1.72e-08 | 0.67 | FALSE |
| NAcc | Zfp958 | gene expression | Zfp958 | 0.09 | 29 | 0.09 | 2.6e-10 | 5.8 | 6.81e-09 | 0.3 | TRUE |
| NAcc | Brca2 | isoform ratio | XM_017598372.2 | 0.06 | 1 | 0.04 | 8.0e-06 | -5.28 | 1.30e-07 | 0.86 | FALSE |
| NAcc | LOC120095871 | isoform ratio | XM_039089913.1 | 0.07 | 1121 | 0.06 | 1.7e-07 | 5.19 | 2.14e-07 | 0.3 | FALSE |
| NAcc | LOC120095871 | isoform ratio | XM_039089914.1 | 0.07 | 1121 | 0.06 | 2.3e-07 | -5.23 | 1.67e-07 | 0.29 | FALSE |
| NAcc | Pex11g | isoform ratio | NM_001105902.1 | 0.03 | 1 | 0.03 | 6.8e-05 | 5.26 | 1.41e-07 | 0.17 | FALSE |
| NAcc | Snapc2 | isoform ratio | NM_001415804.1 | 0.07 | 6 | 0.04 | 2.4e-05 | 5.71 | 1.13e-08 | 0.66 | FALSE |
| NAcc | Stard13 | isoform ratio | XM_039089671.1 | 0.05 | 1 | 0.02 | 1.1e-03 | 5.44 | 5.45e-08 | 0.49 | FALSE |
| NAcc | Pet100 | intron excision ratio | chr12_1680794_1680963 | 0.1 | 6 | 0.05 | 1.2e-06 | -5.4 | 6.83e-08 | 0.6 | FALSE |
| NAcc | Pet100 | mRNA stability | Pet100 | 0.26 | 65 | 0.16 | 8.7e-18 | 5.57 | 2.60e-08 | 0.78 | FALSE |
| OFC | Insr | alternative TSS | XM_039089098.1 | 0.53 | 1 | 0.17 | 8.9e-05 | -5.44 | 5.43e-08 | 0.14 | FALSE |
| OFC | Insr | alternative TSS | XM_039089098.1 | 0.53 | 1 | 0.17 | 8.9e-05 | -5.44 | 5.43e-08 | 0.14 | FALSE |
| OFC | Pet100 | gene expression | Pet100 | 0.69 | 1 | 0.41 | 6.2e-11 | -5.32 | 1.06e-07 | 0.72 | FALSE |
| OFC | Snapc2 | gene expression | Snapc2 | 0.56 | 241 | 0.13 | 5.8e-04 | 6.07 | 1.31e-09 | 0.55 | FALSE |
| OFC | Stxbp2 | gene expression | Stxbp2 | 0.35 | 1 | 0.1 | 2.7e-03 | 5.32 | 1.02e-07 | 0.06 | FALSE |
| OFC | Pex11g | intron excision ratio | chr12_1510501_1512045 | 0.33 | 1 | 0.14 | 3.5e-04 | 5.24 | 1.58e-07 | 0.06 | FALSE |
| OFC | Pex11g | intron excision ratio | chr12_1510501_1512375 | 0.36 | 1 | 0.15 | 1.9e-04 | -5.24 | 1.58e-07 | 0.06 | FALSE |
| PL | N4bp2l1 | alternative TSS | NM_001035222.2 | 0.05 | 1 | 0.04 | 1.4e-05 | 5.33 | 9.73e-08 | 0.69 | FALSE |
| PL | N4bp2l1 | alternative TSS | XM_039089675.1 | 0.05 | 1 | 0.04 | 1.4e-05 | -5.37 | 7.68e-08 | 0.76 | FALSE |
| PL | Snapc2 | alternative TSS | XM_039089313.1 | 0.1 | 2285 | 0.07 | 3.5e-08 | 5.29 | 1.23e-07 | 0.71 | FALSE |
| PL | N4bp2l1 | gene expression | N4bp2l1 | 0.05 | 1 | 0.04 | 3.5e-05 | 5.29 | 1.21e-07 | 0.79 | FALSE |
| PL | Snapc2 | gene expression | Snapc2 | 0.39 | 13 | 0.2 | 5.5e-22 | -5.74 | 9.49e-09 | 0.71 | FALSE |
| PL | Stxbp2 | gene expression | Stxbp2 | 0.09 | 1 | 0.05 | 7.2e-06 | 5.19 | 2.11e-07 | 0.54 | TRUE |
| PL | Pet100 | intron excision ratio | chr12_1680794_1680963 | 0.29 | 1836 | 0.16 | 7.5e-17 | -5.62 | 1.93e-08 | 0.4 | FALSE |
| PL | Pet100 | intron excision ratio | chr12_1680995_1681508 | 0.25 | 1836 | 0.12 | 1.6e-13 | 5.33 | 9.70e-08 | 0.34 | FALSE |
| PL | Trappc5 | mRNA stability | Trappc5 | 0.11 | 11 | 0.06 | 4.1e-07 | -5.21 | 1.93e-07 | 0.72 | FALSE |
| PL | Zfp958 | mRNA stability | Zfp958 | 0.03 | 6 | 0.01 | 8.9e-03 | 5.27 | 1.35e-07 | 0.3 | FALSE |
| pVTA | Snapc2 | alternative TSS | XM_039089313.1 | 0.39 | 20 | 0.07 | 5.5e-04 | 5.79 | 7.03e-09 | 0.69 | FALSE |
| pVTA | Snapc2 | alternative TSS | NM_001415804.1 | 0.21 | 11 | 0.07 | 6.9e-04 | 5.29 | 1.20e-07 | 0.52 | TRUE |
| pVTA | Snapc2 | alternative TSS | XM_039089313.1 | 0.32 | 42 | 0.04 | 1.0e-02 | -5.9 | 3.55e-09 | 0.6 | FALSE |
| pVTA | Arhgef18 | gene expression | Arhgef18 | 0.22 | 1543 | 0.14 | 9.7e-07 | -5.59 | 2.28e-08 | 0.54 | FALSE |
| pVTA | Cers4 | gene expression | Cers4 | 0.42 | 2124 | 0.32 | 2.6e-14 | 5.83 | 5.51e-09 | 0.53 | FALSE |
| pVTA | Insr | isoform ratio | XM_039089096.1 | 0.22 | 1 | 0.11 | 1.8e-05 | 5.32 | 1.02e-07 | 0.34 | FALSE |
| pVTA | Snapc2 | isoform ratio | XM_039089313.1 | 0.51 | 13 | 0.08 | 3.1e-04 | 5.87 | 4.28e-09 | 0.7 | FALSE |
| pVTA | Pet100 | intron excision ratio | chr12_1680995_1681508 | 0.3 | 146 | 0.15 | 4.0e-07 | -5.55 | 2.94e-08 | 0.67 | FALSE |
| RMTg | Insr | intron excision ratio | chr12_1257822_1307450 | 0.46 | 1 | 0.3 | 1.2e-08 | -5.32 | 1.02e-07 | 0.54 | FALSE |
| RMTg | Insr | intron excision ratio | chr12_1264110_1307450 | 0.37 | 1 | 0.21 | 3.1e-06 | 5.32 | 1.02e-07 | 0.15 | FALSE |
| RMTg | Insr | intron excision ratio | chr12_1264114_1307450 | 0.31 | 1 | 0.18 | 1.4e-05 | 5.32 | 1.02e-07 | 0.11 | FALSE |