chr12:22,091-4,653,252

Trait: Tibialis anterior weight

Best TWAS P=9.73e-10 · Best GWAS P=2.41e-08 conditioned to NaN

Associated models

Tissue Gene RNA modality RNA phenotype h2 # weights Model R2 Model R2 P TWAS Z TWAS P Coloc P Joint
Adipose Brca2 alternative polyA XM_039089544.1 0.03 1 0.02 2.4e-03 -5.34 9.40e-08 0.09 FALSE
Adipose Elavl1 alternative TSS XM_039089620.1 0.24 2417 0.11 7.3e-12 -5.52 3.46e-08 0.24 FALSE
Adipose Elavl1 alternative TSS XM_039089620.1 0.17 2417 0.07 1.7e-08 -5.46 4.65e-08 0.24 FALSE
Adipose Elavl1 alternative TSS XM_039089621.1 0.15 2417 0.07 7.6e-08 5.46 4.79e-08 0.24 FALSE
Adipose LOC102552452 alternative TSS XR_005491757.1 0.03 24 0.01 1.7e-02 -5.2 1.99e-07 0.54 FALSE
Adipose LOC120095871 alternative TSS XM_039089913.1 0.05 15 0.03 8.1e-04 5.41 6.35e-08 0.29 FALSE
Adipose LOC120095871 alternative TSS XM_039089914.1 0.05 18 0.02 1.1e-03 -5.43 5.69e-08 0.29 FALSE
Adipose Snapc2 alternative TSS NM_001415804.1 0.04 53 0.02 6.3e-03 5.23 1.70e-07 0.51 TRUE
Adipose Stard13 alternative TSS XM_039089673.1 0.03 1441 0.02 6.6e-03 -5.54 3.03e-08 0.41 FALSE
Adipose Stard13 alternative TSS XM_006248749.4 0.03 1441 0.02 4.3e-03 -5.27 1.37e-07 0.38 FALSE
Adipose Stard13 alternative TSS XM_039089673.1 0.04 1441 0.02 1.6e-03 -5.52 3.44e-08 0.52 FALSE
Adipose LOC102549089 gene expression LOC102549089 0.12 19 0.05 1.9e-06 -5.66 1.53e-08 0.86 FALSE
Adipose Map2k7 gene expression Map2k7 0.06 2244 0.03 2.3e-04 -5.59 2.30e-08 0.46 FALSE
Adipose N4bp2l1 gene expression N4bp2l1 0.36 19 0.28 1.1e-31 5.41 6.29e-08 0.93 FALSE
Adipose Trappc5 gene expression Trappc5 0.08 62 0.04 9.4e-06 6.11 9.73e-10 0.68 TRUE
Adipose Xab2 gene expression Xab2 0.13 35 0.05 5.7e-06 5.22 1.78e-07 0.46 FALSE
Adipose Elavl1 isoform ratio NM_001108848.1 0.14 2417 0.04 1.9e-05 5.31 1.09e-07 0.19 FALSE
Adipose Elavl1 isoform ratio XM_039089620.1 0.26 219 0.12 4.8e-13 5.5 3.79e-08 0.24 FALSE
Adipose Elavl1 mRNA stability Elavl1 0.27 130 0.12 6.3e-13 -5.72 1.08e-08 0.24 FALSE
Adipose N4bp2l1 mRNA stability N4bp2l1 0.05 597 0.03 1.6e-04 5.45 5.08e-08 0.74 FALSE
BLA N4bp2l2 alternative polyA XM_039089150.1 0.06 702 0.04 3.0e-03 5.44 5.41e-08 0.56 FALSE
BLA Stxbp2 alternative polyA XM_039089805.1 0.15 1833 0.04 2.2e-03 -5.42 6.01e-08 0.54 FALSE
BLA N4bp2l2 gene expression N4bp2l2 0.08 1 0.05 1.6e-03 -5.37 7.68e-08 0.09 FALSE
BLA Snapc2 gene expression Snapc2 0.16 15 0.06 3.7e-04 5.97 2.34e-09 0.41 FALSE
BLA Stxbp2 gene expression Stxbp2 0.13 1 0.07 1.1e-04 5.3 1.17e-07 0.18 FALSE
BLA N4bp2l2 isoform ratio XM_039089150.1 0.06 702 0.05 9.4e-04 5.33 9.97e-08 0.56 FALSE
BLA Snapc2 isoform ratio XM_039089313.1 0.15 2285 0.04 5.8e-03 5.69 1.24e-08 0.52 FALSE
BLA Stard13 isoform ratio XM_039089671.1 0.08 1 0.04 2.5e-03 5.21 1.88e-07 0.11 FALSE
BLA Pet100 intron excision ratio chr12_1680794_1680963 0.34 21 0.2 3.9e-11 -5.69 1.24e-08 0.81 FALSE
BLA Pet100 intron excision ratio chr12_1680995_1681508 0.33 1836 0.2 1.0e-10 5.38 7.64e-08 0.8 FALSE
Brain Stxbp2 alternative polyA XM_039089804.1 0.09 1 0.07 1.0e-06 -5.19 2.09e-07 0.59 FALSE
Brain Stxbp2 alternative polyA XM_039089805.1 0.13 1 0.12 4.9e-11 5.19 2.09e-07 0.61 FALSE
Brain Arhgef18 alternative TSS NM_001395655.1 0.09 9 0.05 3.3e-05 -5.29 1.20e-07 0.28 FALSE
Brain Arhgef18 alternative TSS XM_039089307.1 0.1 11 0.05 4.3e-05 5.25 1.50e-07 0.23 FALSE
Brain Insr alternative TSS XM_039089098.1 0.34 48 0.2 2.4e-18 -5.77 7.87e-09 0.86 FALSE
Brain Insr alternative TSS XM_039089097.1 0.33 103 0.2 7.0e-18 5.5 3.71e-08 0.86 FALSE
Brain Insr alternative TSS XM_039089098.1 0.34 48 0.2 3.5e-18 -5.78 7.53e-09 0.86 FALSE
Brain Pcp2 alternative TSS XM_008768953.3 0.13 17 0.09 4.8e-09 5.26 1.47e-07 0.7 FALSE
Brain Snapc2 alternative TSS NM_001415804.1 0.22 1 0.19 1.1e-17 5.19 2.15e-07 0.79 FALSE
Brain Snapc2 alternative TSS XM_039089313.1 0.79 1 0.28 7.5e-26 -5.19 2.15e-07 0.79 FALSE
Brain Snapc2 alternative TSS NM_001415804.1 0.24 1 0.2 1.1e-18 5.19 2.15e-07 0.79 FALSE
Brain Snapc2 alternative TSS XM_039089313.1 0.71 1 0.24 4.0e-22 -5.19 2.15e-07 0.79 FALSE
Brain Elavl1 gene expression Elavl1 0.1 2419 0.05 2.7e-05 -5.59 2.25e-08 0.32 FALSE
Brain Pcp2 gene expression Pcp2 0.11 1 0.08 3.0e-08 -5.29 1.20e-07 0.73 FALSE
Brain Arhgef18 isoform ratio NM_001395655.1 0.08 11 0.06 1.1e-06 -5.63 1.78e-08 0.62 FALSE
Brain Arhgef18 isoform ratio XM_039089307.1 0.07 25 0.06 3.7e-06 5.49 3.92e-08 0.53 FALSE
Brain Insr isoform ratio XM_039089096.1 0.23 1 0.16 1.5e-14 5.42 6.13e-08 0.83 FALSE
Brain Insr isoform ratio XM_039089097.1 0.09 1555 0.06 1.8e-06 5.59 2.31e-08 0.56 FALSE
Brain Pex11g isoform ratio NM_001105902.1 0.04 1 0.04 1.7e-04 -5.2 2.03e-07 0.35 FALSE
Brain Snapc2 isoform ratio NM_001415804.1 0.23 1 0.2 2.2e-18 5.19 2.15e-07 0.79 FALSE
Brain Snapc2 isoform ratio XM_039089313.1 0.36 1 0.25 7.3e-23 -5.19 2.15e-07 0.79 FALSE
Brain Pet100 intron excision ratio chr12_1680794_1680963 0.07 1 0.04 1.4e-04 5.34 9.20e-08 0.47 FALSE
Brain Pet100 intron excision ratio chr12_1680995_1681508 0.06 1 0.03 5.9e-04 -5.34 9.20e-08 0.31 FALSE
Brain Elavl1 mRNA stability Elavl1 0.14 12 0.07 5.1e-07 5.63 1.83e-08 0.5 FALSE
Brain Insr mRNA stability Insr 0.76 157 0.6 1.5e-69 -5.44 5.41e-08 0.82 FALSE
Eye Stxbp2 alternative polyA XM_039089804.1 0.64 50 0.28 3.5e-05 5.36 8.35e-08 0.42 FALSE
Eye Elavl1 intron excision ratio chr12_2667464_2684652 0.69 8 0.37 1.3e-06 5.37 8.08e-08 0.29 FALSE
Eye LOC120095871 intron excision ratio chr12_3871255_3873703 0.33 132 0.09 1.8e-02 -5.68 1.36e-08 0.39 FALSE
Eye Insr mRNA stability Insr 0.82 1 0.26 6.5e-05 -5.32 1.02e-07 0.07 FALSE
IL LOC102552452 gene expression LOC102552452 0.51 100 0.32 2.3e-08 -5.84 5.35e-09 0.64 FALSE
LHb Insr intron excision ratio chr12_1257822_1307450 0.71 407 0.34 5.1e-09 -5.63 1.85e-08 0.66 FALSE
LHb Brca2 mRNA stability Brca2 0.29 435 0.12 7.5e-04 5.28 1.29e-07 0.65 FALSE
Liver Stxbp2 alternative polyA XM_006248783.4 0.07 39 0.06 2.8e-07 5.44 5.39e-08 0 FALSE
Liver Stxbp2 alternative polyA XM_039089804.1 0.42 31 0.28 2.4e-31 -5.52 3.32e-08 0.7 FALSE
Liver Stxbp2 alternative polyA NM_031126.1 0.07 32 0.06 2.5e-07 -5.24 1.58e-07 0 FALSE
Liver Brca2 gene expression Brca2 0.04 1 0.03 4.3e-04 -5.34 9.40e-08 0.23 FALSE
Liver Cd209a gene expression Cd209a 0.2 234 0.05 4.9e-06 5.39 6.99e-08 0.16 FALSE
Liver LOC102552452 gene expression LOC102552452 0.59 7 0.37 1.4e-42 5.33 9.76e-08 0.65 FALSE
Liver Mcoln1 gene expression Mcoln1 0.07 1 0.03 1.2e-04 -5.48 4.23e-08 0.43 FALSE
Liver N4bp2l1 gene expression N4bp2l1 0.2 88 0.16 4.6e-17 5.32 1.04e-07 0.65 FALSE
Liver Pex11g isoform ratio XM_017598285.2 0.06 1 0.03 2.9e-04 -5.29 1.25e-07 0.23 FALSE
Liver Insr intron excision ratio chr12_1257822_1307450 0.4 1 0.19 6.8e-21 -5.38 7.44e-08 0.8 FALSE
Liver Pet100 intron excision ratio chr12_1680794_1680963 0.2 76 0.1 4.0e-11 5.56 2.65e-08 0.73 FALSE
Liver Pet100 intron excision ratio chr12_1680995_1681508 0.18 19 0.07 2.4e-08 5.55 2.90e-08 0.53 FALSE
Liver Brca2 mRNA stability Brca2 0.18 431 0.13 2.3e-14 5.51 3.60e-08 0.89 FALSE
Liver Elavl1 mRNA stability Elavl1 0.08 2417 0.04 4.1e-05 5.53 3.25e-08 0.37 FALSE
Liver Pet100 mRNA stability Pet100 0.5 1831 0.31 3.8e-35 5.91 3.42e-09 0.83 FALSE
NAcc N4bp2l2 alternative polyA XM_039089150.1 0.03 1 0.02 1.4e-03 -5.36 8.45e-08 0.12 FALSE
NAcc Snapc2 alternative TSS NM_001415804.1 0.09 2285 0.06 5.2e-07 -5.52 3.39e-08 0.59 FALSE
NAcc Snapc2 alternative TSS XM_039089313.1 0.07 2285 0.03 6.7e-04 5.43 5.58e-08 0.42 FALSE
NAcc Snapc2 alternative TSS NM_001415804.1 0.08 2285 0.04 6.5e-06 -5.53 3.13e-08 0.59 FALSE
NAcc Snapc2 alternative TSS XM_039089313.1 0.07 16 0.03 2.4e-04 -5.32 1.01e-07 0.32 FALSE
NAcc Arhgef18 gene expression Arhgef18 0.09 1543 0.04 2.3e-05 -5.59 2.26e-08 0.58 FALSE
NAcc Cers4 gene expression Cers4 0.39 56 0.41 1.3e-51 -5.86 4.73e-09 0.59 FALSE
NAcc Snapc2 gene expression Snapc2 0.15 1 0.07 1.1e-08 5.43 5.77e-08 0.93 FALSE
NAcc Stxbp2 gene expression Stxbp2 0.1 1833 0.05 7.4e-07 -5.64 1.72e-08 0.67 FALSE
NAcc Zfp958 gene expression Zfp958 0.09 29 0.09 2.6e-10 5.8 6.81e-09 0.3 TRUE
NAcc Brca2 isoform ratio XM_017598372.2 0.06 1 0.04 8.0e-06 -5.28 1.30e-07 0.86 FALSE
NAcc LOC120095871 isoform ratio XM_039089913.1 0.07 1121 0.06 1.7e-07 5.19 2.14e-07 0.3 FALSE
NAcc LOC120095871 isoform ratio XM_039089914.1 0.07 1121 0.06 2.3e-07 -5.23 1.67e-07 0.29 FALSE
NAcc Pex11g isoform ratio NM_001105902.1 0.03 1 0.03 6.8e-05 5.26 1.41e-07 0.17 FALSE
NAcc Snapc2 isoform ratio NM_001415804.1 0.07 6 0.04 2.4e-05 5.71 1.13e-08 0.66 FALSE
NAcc Stard13 isoform ratio XM_039089671.1 0.05 1 0.02 1.1e-03 5.44 5.45e-08 0.49 FALSE
NAcc Pet100 intron excision ratio chr12_1680794_1680963 0.1 6 0.05 1.2e-06 -5.4 6.83e-08 0.6 FALSE
NAcc Pet100 mRNA stability Pet100 0.26 65 0.16 8.7e-18 5.57 2.60e-08 0.78 FALSE
OFC Insr alternative TSS XM_039089098.1 0.53 1 0.17 8.9e-05 -5.44 5.43e-08 0.14 FALSE
OFC Insr alternative TSS XM_039089098.1 0.53 1 0.17 8.9e-05 -5.44 5.43e-08 0.14 FALSE
OFC Pet100 gene expression Pet100 0.69 1 0.41 6.2e-11 -5.32 1.06e-07 0.72 FALSE
OFC Snapc2 gene expression Snapc2 0.56 241 0.13 5.8e-04 6.07 1.31e-09 0.55 FALSE
OFC Stxbp2 gene expression Stxbp2 0.35 1 0.1 2.7e-03 5.32 1.02e-07 0.06 FALSE
OFC Pex11g intron excision ratio chr12_1510501_1512045 0.33 1 0.14 3.5e-04 5.24 1.58e-07 0.06 FALSE
OFC Pex11g intron excision ratio chr12_1510501_1512375 0.36 1 0.15 1.9e-04 -5.24 1.58e-07 0.06 FALSE
PL N4bp2l1 alternative TSS NM_001035222.2 0.05 1 0.04 1.4e-05 5.33 9.73e-08 0.69 FALSE
PL N4bp2l1 alternative TSS XM_039089675.1 0.05 1 0.04 1.4e-05 -5.37 7.68e-08 0.76 FALSE
PL Snapc2 alternative TSS XM_039089313.1 0.1 2285 0.07 3.5e-08 5.29 1.23e-07 0.71 FALSE
PL N4bp2l1 gene expression N4bp2l1 0.05 1 0.04 3.5e-05 5.29 1.21e-07 0.79 FALSE
PL Snapc2 gene expression Snapc2 0.39 13 0.2 5.5e-22 -5.74 9.49e-09 0.71 FALSE
PL Stxbp2 gene expression Stxbp2 0.09 1 0.05 7.2e-06 5.19 2.11e-07 0.54 TRUE
PL Pet100 intron excision ratio chr12_1680794_1680963 0.29 1836 0.16 7.5e-17 -5.62 1.93e-08 0.4 FALSE
PL Pet100 intron excision ratio chr12_1680995_1681508 0.25 1836 0.12 1.6e-13 5.33 9.70e-08 0.34 FALSE
PL Trappc5 mRNA stability Trappc5 0.11 11 0.06 4.1e-07 -5.21 1.93e-07 0.72 FALSE
PL Zfp958 mRNA stability Zfp958 0.03 6 0.01 8.9e-03 5.27 1.35e-07 0.3 FALSE
pVTA Snapc2 alternative TSS XM_039089313.1 0.39 20 0.07 5.5e-04 5.79 7.03e-09 0.69 FALSE
pVTA Snapc2 alternative TSS NM_001415804.1 0.21 11 0.07 6.9e-04 5.29 1.20e-07 0.52 TRUE
pVTA Snapc2 alternative TSS XM_039089313.1 0.32 42 0.04 1.0e-02 -5.9 3.55e-09 0.6 FALSE
pVTA Arhgef18 gene expression Arhgef18 0.22 1543 0.14 9.7e-07 -5.59 2.28e-08 0.54 FALSE
pVTA Cers4 gene expression Cers4 0.42 2124 0.32 2.6e-14 5.83 5.51e-09 0.53 FALSE
pVTA Insr isoform ratio XM_039089096.1 0.22 1 0.11 1.8e-05 5.32 1.02e-07 0.34 FALSE
pVTA Snapc2 isoform ratio XM_039089313.1 0.51 13 0.08 3.1e-04 5.87 4.28e-09 0.7 FALSE
pVTA Pet100 intron excision ratio chr12_1680995_1681508 0.3 146 0.15 4.0e-07 -5.55 2.94e-08 0.67 FALSE
RMTg Insr intron excision ratio chr12_1257822_1307450 0.46 1 0.3 1.2e-08 -5.32 1.02e-07 0.54 FALSE
RMTg Insr intron excision ratio chr12_1264110_1307450 0.37 1 0.21 3.1e-06 5.32 1.02e-07 0.15 FALSE
RMTg Insr intron excision ratio chr12_1264114_1307450 0.31 1 0.18 1.4e-05 5.32 1.02e-07 0.11 FALSE