chr7:132,718,764-135,716,749

Trait: Tibialis anterior weight

Best TWAS P = 3.64e-11 · Best GWAS P= 1.17e-10 conditioned to 1.00e+00

Associated models

Tissue Gene RNA modality RNA phenotype h2 # weights Model R2 Model R2 P TWAS Z TWAS P Coloc P Joint
Adipose Scn8a alternative polyA NM_019266.3 0.29 178 0.29 2.7e-32 -5.99 2.14e-09 0.78 FALSE
Adipose Scn8a alternative polyA XM_063263132.1 0.28 176 0.27 1.8e-30 5.95 2.66e-09 0.78 FALSE
Adipose Scn8a alternative polyA NM_019266.3 0.3 177 0.3 9.6e-34 -5.95 2.61e-09 0.78 FALSE
Adipose Scn8a alternative polyA XM_063263132.1 0.3 177 0.3 4.0e-33 5.93 3.08e-09 0.78 FALSE
Adipose Krt80 alternative TSS NM_001008815.2 0.03 1 0.04 1.0e-05 5.36 8.53e-08 0.03 FALSE
Adipose Krt80 alternative TSS XM_063263678.1 0.03 1 0.04 1.5e-05 -5.36 8.53e-08 0.03 FALSE
Adipose Pou6f1 alternative TSS XM_063262865.1 0.03 6 0.01 4.3e-02 5.63 1.85e-08 0.32 FALSE
Adipose Acvrl1 gene expression Acvrl1 0.07 1122 0.04 2.6e-05 -6.62 3.64e-11 0.6 TRUE
Adipose Atg101 gene expression Atg101 0.07 1127 0.06 8.3e-07 6.48 9.42e-11 0.54 FALSE
Adipose Dazap2 gene expression Dazap2 0.22 83 0.11 1.2e-12 -5.41 6.42e-08 0.01 FALSE
Adipose Krt80 gene expression Krt80 0.09 1115 0.04 9.4e-06 6.23 4.56e-10 0.47 FALSE
Adipose Krt81 gene expression Krt81 0.03 1306 0.02 1.2e-03 6.17 6.85e-10 0.49 FALSE
Adipose Krt86 gene expression Krt86 0.09 1 0.1 4.1e-11 -6.16 7.13e-10 0.32 FALSE
Adipose LOC120093741 gene expression LOC120093741 0.02 1 0.02 5.3e-03 -5.45 5.01e-08 0.03 FALSE
Adipose Pou6f1 gene expression Pou6f1 0.29 1 0.13 3.3e-14 -5.28 1.31e-07 0.04 FALSE
Adipose Scn8a gene expression Scn8a 0.66 1 0.62 5.4e-88 -6.27 3.65e-10 0.69 FALSE
Adipose Slc11a2 gene expression Slc11a2 0.43 25 0.23 1.1e-25 -5.39 7.09e-08 0.19 FALSE
Adipose Slc4a8 gene expression Slc4a8 0.19 13 0.22 7.6e-24 5.46 4.72e-08 0.04 FALSE
Adipose Atg101 isoform ratio NM_001007659.2 0.02 1127 0.01 1.2e-02 -6.35 2.22e-10 0.43 FALSE
Adipose Atg101 isoform ratio NM_001271114.1 0.05 1 0.03 1.6e-04 -6.19 6.05e-10 0.05 FALSE
Adipose Csad isoform ratio XM_006242438.5 0.02 1139 0.02 2.7e-03 5.43 5.76e-08 0.08 FALSE
Adipose Dazap2 isoform ratio NM_001395672.1 0.13 9 0.07 1.2e-08 5.24 1.60e-07 0.03 FALSE
Adipose Dazap2 isoform ratio NM_001395673.1 0.13 13 0.09 6.4e-10 5.26 1.42e-07 0.02 FALSE
Adipose Krt80 isoform ratio NM_001008815.2 0.03 1 0.03 2.2e-04 5.36 8.53e-08 0.03 FALSE
Adipose Krt80 isoform ratio XM_063263678.1 0.03 1 0.04 4.6e-05 -5.36 8.53e-08 0.03 FALSE
Adipose Scn8a isoform ratio NM_019266.3 0.27 164 0.25 2.6e-27 -5.9 3.72e-09 0.78 FALSE
Adipose Scn8a isoform ratio XM_063263133.1 0.05 12 0.01 1.3e-02 -5.24 1.57e-07 0.61 FALSE
Adipose Scn8a isoform ratio XM_063263135.1 0.1 1 0.07 1.3e-08 5.44 5.23e-08 0.02 FALSE
Adipose Atg101 mRNA stability Atg101 0.06 1 0.05 4.8e-06 -6.27 3.65e-10 0.43 FALSE
Adipose Krt80 mRNA stability Krt80 0.14 1 0.14 5.3e-15 6.3 2.90e-10 0.53 FALSE
Adipose Tfcp2 mRNA stability Tfcp2 0.03 12 0.03 2.6e-04 5.7 1.17e-08 0.35 FALSE
BLA LOC120093735 alternative TSS XR_010053106.1 0.05 19 0.02 2.5e-02 -5.6 2.19e-08 0.3 FALSE
BLA Slc11a2 alternative TSS NM_001399169.1 0.13 9 0.1 5.3e-06 5.3 1.16e-07 0.65 TRUE
BLA Slc11a2 alternative TSS XM_006242312.5 0.14 1629 0.11 2.1e-06 5.58 2.47e-08 0.66 FALSE
BLA Slc11a2 alternative TSS NM_001399169.1 0.14 1629 0.1 4.4e-06 -5.6 2.18e-08 0.63 FALSE
BLA Slc11a2 alternative TSS XM_006242312.5 0.14 1629 0.11 2.3e-06 5.57 2.52e-08 0.66 FALSE
BLA Galnt6 gene expression Galnt6 0.43 36 0.44 3.3e-25 5.81 6.19e-09 0.75 FALSE
BLA Krt75 gene expression Krt75 0.11 1 0.06 6.8e-04 6.27 3.57e-10 0.05 FALSE
BLA LOC108351555 gene expression LOC108351555 0.04 1301 0.03 7.0e-03 6 1.98e-09 0.33 FALSE
BLA Pou6f1 gene expression Pou6f1 0.24 1663 0.28 6.7e-15 5.61 1.97e-08 0.3 FALSE
BLA Atg101 isoform ratio NM_001007659.2 0.15 1 0.14 8.4e-08 6.35 2.17e-10 0.56 FALSE
BLA Atg101 isoform ratio NM_001271114.1 0.12 1 0.1 4.9e-06 -6.26 3.81e-10 0.32 FALSE
BLA Rarg isoform ratio XM_008765785.4 0.23 947 0.03 7.3e-03 -5.45 4.93e-08 0.24 TRUE
BLA Atg101 intron excision ratio chr7_134277496_134280164 0.06 1127 0.04 4.3e-03 -6.19 6.20e-10 0.4 FALSE
BLA Atg101 intron excision ratio chr7_134277496_134280459 0.06 1127 0.06 3.4e-04 6.16 7.22e-10 0.48 FALSE
BLA Atg101 intron excision ratio chr7_134280338_134280459 0.06 1127 0.05 1.3e-03 -6.11 1.02e-09 0.43 FALSE
BLA Pfdn5 intron excision ratio chr7_135330757_135331042 0.23 1 0.04 4.8e-03 5.32 1.01e-07 0.06 FALSE
BLA Acvr1b mRNA stability Acvr1b 0.09 1 0.04 5.3e-03 5.31 1.10e-07 0.04 FALSE
BLA Scn8a mRNA stability Scn8a 0.04 1377 0.02 2.6e-02 5.99 2.10e-09 0.32 FALSE
Brain Pou6f1 alternative polyA NM_001105746.1 0.04 1663 0.03 3.7e-04 -5.8 6.83e-09 0.57 FALSE
Brain Pou6f1 alternative polyA XM_039078246.2 0.03 1663 0.03 5.0e-04 5.79 6.87e-09 0.6 FALSE
Brain Atg101 alternative TSS NM_001007659.2 0.04 1127 0.02 5.2e-03 -6.09 1.16e-09 0.43 FALSE
Brain Atg101 alternative TSS XM_006242324.5 0.04 1127 0.02 5.7e-03 6.07 1.28e-09 0.42 FALSE
Brain Pou6f1 alternative TSS XM_063262865.1 0.08 1663 0.06 7.7e-06 5.49 4.07e-08 0.29 FALSE
Brain Atg101 gene expression Atg101 0.07 1127 0.06 2.7e-06 6.3 3.07e-10 0.61 FALSE
Brain Dazap2 gene expression Dazap2 0.49 30 0.2 5.0e-18 5.31 1.11e-07 0 FALSE
Brain Galnt6 gene expression Galnt6 0.44 139 0.53 2.0e-58 -5.83 5.70e-09 0.7 FALSE
Brain Krt1 gene expression Krt1 0.13 29 0.15 4.9e-14 6.2 5.65e-10 0.51 FALSE
Brain Atg101 isoform ratio NM_001007659.2 0.11 1127 0.06 2.7e-06 -6.09 1.10e-09 0.57 FALSE
Brain Atg101 isoform ratio NM_001271114.1 0.08 1127 0.08 9.2e-08 6.02 1.73e-09 0.44 FALSE
Brain Atg101 intron excision ratio chr7_134277496_134280164 0.04 1127 0.04 2.1e-04 -6.1 1.07e-09 0.49 FALSE
Brain Atg101 intron excision ratio chr7_134277496_134280459 0.08 153 0.08 7.0e-08 -5.46 4.71e-08 0.39 FALSE
Brain Dazap2 intron excision ratio chr7_133595215_133595901 0.05 1638 0.04 1.1e-04 5.53 3.15e-08 0.44 FALSE
Brain Dazap2 intron excision ratio chr7_133596146_133597663 0.04 1638 0.03 1.8e-03 -5.47 4.41e-08 0.37 FALSE
Brain Atg101 mRNA stability Atg101 0.03 1127 0.03 7.8e-04 6.2 5.67e-10 0.49 FALSE
Brain Scn8a mRNA stability Scn8a 0.03 1 0.01 1.9e-02 -5.4 6.82e-08 0.03 FALSE
Brain Slc4a8 mRNA stability Slc4a8 0.25 1430 0.27 1.5e-25 -5.43 5.55e-08 0.58 FALSE
Brain Tfcp2 mRNA stability Tfcp2 0.14 1686 0.15 4.1e-14 -5.57 2.48e-08 0.38 FALSE
Eye Krt6a gene expression Krt6a 0.6 1361 0.18 1.0e-03 6.29 3.13e-10 0.35 FALSE
Eye Krt6c gene expression Krt6c 0.82 35 0.24 1.2e-04 -6.3 2.88e-10 0.42 FALSE
Eye Krt7 gene expression Krt7 0.87 1136 0.05 5.5e-02 5.61 2.05e-08 0.21 FALSE
Eye LOC120093742 gene expression LOC120093742 0.42 1351 0.15 2.9e-03 6.02 1.71e-09 0.21 FALSE
Eye Krt4 isoform ratio NM_001008806.2 0.5 28 0.1 1.2e-02 6.13 8.82e-10 0.31 FALSE
Eye Krt4 isoform ratio XM_006242395.5 0.48 1 0.09 2.1e-02 6.24 4.32e-10 0.06 FALSE
Eye Krt5 intron excision ratio chr7_134711342_134729940 0.46 1376 0.18 1.0e-03 6.23 4.79e-10 0.37 FALSE
Eye Krt5 intron excision ratio chr7_134729414_134729940 0.44 1376 0.19 8.0e-04 -6.15 7.59e-10 0.37 FALSE
Eye Krt6a intron excision ratio chr7_134711342_134729940 0.46 1361 0.18 1.0e-03 6.22 4.89e-10 0.37 FALSE
Eye Krt6a intron excision ratio chr7_134729414_134729940 0.44 1361 0.19 7.8e-04 -6.15 7.81e-10 0.37 FALSE
Eye Krt75 intron excision ratio chr7_134573721_134573960 0.29 1 0.09 1.6e-02 -6.36 2.03e-10 0.06 FALSE
Eye Dazap2 mRNA stability Dazap2 0.55 24 0.24 1.4e-04 -5.29 1.19e-07 0.3 FALSE
IC Slc11a2 alternative TSS XM_006242312.5 0.11 2 0.16 2.9e-07 5.23 1.70e-07 0.18 FALSE
IC Acvrl1 gene expression Acvrl1 0.61 1122 0.02 4.1e-02 5.91 3.45e-09 0.33 FALSE
IC Galnt6 gene expression Galnt6 0.23 40 0.23 6.9e-10 5.36 8.53e-08 0.27 FALSE
IC Krt1 gene expression Krt1 0.06 1 0.07 8.4e-04 -6.26 3.77e-10 0.05 FALSE
IL Krt1 gene expression Krt1 0.12 1 0.03 6.1e-02 -6.42 1.34e-10 0.06 FALSE
IL Krt77 gene expression Krt77 0.29 1 0.02 9.1e-02 5.22 1.80e-07 0.05 FALSE
IL Pou6f1 gene expression Pou6f1 0.55 200 0.32 1.7e-08 -5.95 2.75e-09 0.44 FALSE
LHb Dazap2 gene expression Dazap2 0.3 6 0.14 4.3e-04 5.23 1.73e-07 0.56 FALSE
LHb Krt77 gene expression Krt77 0.16 128 0.15 2.1e-04 5.3 1.15e-07 0.28 FALSE
Liver Pou6f1 alternative TSS XM_039078248.2 0.04 1663 0.03 4.1e-04 5.29 1.23e-07 0.04 FALSE
Liver Atg101 gene expression Atg101 0.02 1127 0.01 9.4e-03 6.16 7.26e-10 0.37 FALSE
Liver Krt7 gene expression Krt7 0.03 1 0.01 2.7e-02 5.65 1.56e-08 0.03 FALSE
Liver Krt71 gene expression Krt71 0.2 21 0.11 6.1e-12 5.98 2.23e-09 0.57 FALSE
Liver Tmdd1 gene expression Tmdd1 0.05 1189 0.03 9.8e-05 -6.17 6.94e-10 0.6 FALSE
Liver Atg101 isoform ratio NM_001007659.2 0.05 1 0.06 6.6e-07 6.19 6.05e-10 0.31 FALSE
Liver Atg101 isoform ratio NM_001271114.1 0.07 1127 0.07 8.5e-08 6.06 1.37e-09 0.45 FALSE
Liver Smagp isoform ratio NM_182817.2 0.03 1616 0.02 2.5e-03 -5.72 1.05e-08 0.34 FALSE
Liver Znf740 isoform ratio XM_063264457.1 0.02 1137 0.02 5.3e-03 5.63 1.83e-08 0.29 FALSE
Liver Atg101 intron excision ratio chr7_134277496_134280164 0.05 1 0.03 2.4e-04 5.65 1.56e-08 0.03 FALSE
Liver Atg101 intron excision ratio chr7_134277496_134280459 0.04 1127 0.03 1.7e-04 6.1 1.08e-09 0.44 FALSE
Liver Atg101 mRNA stability Atg101 0.03 1127 0.02 1.3e-03 6.11 9.69e-10 0.45 FALSE
NAcc Scn8a alternative polyA XM_063263132.1 0.03 1377 0.03 1.7e-05 -5.87 4.23e-09 0.38 FALSE
NAcc Scn8a alternative polyA XM_063263132.1 0.03 1377 0.03 1.2e-05 -5.9 3.61e-09 0.41 FALSE
NAcc Scn8a alternative TSS XM_063263135.1 0.02 52 0.02 1.6e-03 5.41 6.47e-08 0.4 FALSE
NAcc Atg101 gene expression Atg101 0.03 1 0.03 7.0e-06 -5.68 1.37e-08 0.03 FALSE
NAcc Galnt6 gene expression Galnt6 0.34 139 0.46 1.3e-78 -5.74 9.45e-09 0.75 FALSE
NAcc Krt1 gene expression Krt1 0.12 1356 0.3 1.5e-45 5.98 2.24e-09 0.22 FALSE
NAcc Krt71 gene expression Krt71 0.13 7 0.18 3.3e-26 6.38 1.77e-10 0.41 FALSE
NAcc Krt75 gene expression Krt75 0.05 1302 0.06 6.2e-10 6.07 1.27e-09 0.4 FALSE
NAcc Letmd1 gene expression Letmd1 0.08 11 0.06 5.2e-10 5.26 1.45e-07 0.21 FALSE
NAcc LOC120093742 gene expression LOC120093742 0.02 1409 0.03 6.6e-05 6.14 8.50e-10 0.53 FALSE
NAcc Pou6f1 gene expression Pou6f1 0.28 1663 0.31 5.1e-48 5.32 1.05e-07 0 FALSE
NAcc Slc4a8 gene expression Slc4a8 0.03 1430 0.02 1.8e-04 -5.49 4.02e-08 0.5 FALSE
NAcc Atg101 isoform ratio NM_001007659.2 0.3 1 0.05 7.0e-08 5.68 1.37e-08 0.03 FALSE
NAcc Atg101 isoform ratio NM_001271114.1 0.31 2 0.06 2.5e-09 6.27 3.62e-10 0.53 TRUE
NAcc Scn8a isoform ratio XM_063263132.1 0.02 1 0.01 8.2e-03 -6.05 1.47e-09 0.03 FALSE
NAcc Scn8a isoform ratio XM_063263135.1 0.02 1377 0.01 3.0e-03 -5.27 1.40e-07 0.36 FALSE
NAcc Slc11a2 isoform ratio XM_006242312.5 0.09 85 0.09 9.0e-14 -5.71 1.12e-08 0 FALSE
NAcc Slc4a8 isoform ratio NM_199497.3 0.02 1430 0.01 1.0e-02 5.83 5.46e-09 0.46 FALSE
NAcc Atg101 intron excision ratio chr7_134277496_134280164 0.02 1127 0.02 1.5e-03 -6.35 2.19e-10 0.5 FALSE
NAcc Atg101 intron excision ratio chr7_134277496_134280459 0.22 2 0.03 7.0e-05 6.33 2.42e-10 0.55 FALSE
NAcc Csad intron excision ratio chr7_135188990_135189131 0.03 1139 0.01 4.1e-03 -5.83 5.68e-09 0.62 FALSE
NAcc Dazap2 intron excision ratio chr7_133595215_133595901 0.02 1638 0.01 5.5e-03 5.64 1.67e-08 0.45 FALSE
NAcc Galnt6 intron excision ratio chr7_133698437_133705770 0.03 1465 0.02 1.3e-03 5.81 6.22e-09 0.3 FALSE
NAcc Scn8a intron excision ratio chr7_134004549_134004813 0.02 65 0.01 2.2e-02 5.92 3.28e-09 0.4 FALSE
NAcc Atg101 mRNA stability Atg101 0.03 1 0.04 3.5e-06 -5.44 5.22e-08 0.02 FALSE
NAcc Krt71 mRNA stability Krt71 0.03 1457 0.04 7.7e-07 5.6 2.15e-08 0.14 TRUE
OFC Galnt6 gene expression Galnt6 0.3 1465 0.12 1.0e-03 5.47 4.48e-08 0.12 FALSE
OFC Tamalin intron excision ratio chr7_134223631_134223740 0.13 1 0.1 3.0e-03 5.44 5.22e-08 0.05 FALSE
PL Atg101 alternative TSS NM_001007659.2 0.02 1 0.01 1.1e-02 5.81 6.35e-09 0.03 FALSE
PL Galnt6 alternative TSS NM_001172063.2 0.03 1 0.02 5.0e-03 -5.44 5.42e-08 0.03 FALSE
PL Dazap2 gene expression Dazap2 0.11 13 0.1 7.0e-11 5.25 1.49e-07 0.02 TRUE
PL Galnt6 gene expression Galnt6 0.18 26 0.2 2.4e-21 -5.73 1.02e-08 0.07 FALSE
PL Krt1 gene expression Krt1 0.11 1 0.15 2.9e-16 -5.29 1.22e-07 0.01 FALSE
PL Krt76 gene expression Krt76 0.02 1248 0.01 1.1e-02 5.79 7.17e-09 0.21 FALSE
PL Krt80 gene expression Krt80 0.06 1115 0.08 3.7e-09 6.2 5.64e-10 0.56 FALSE
PL Tamalin gene expression Tamalin 0.03 1 0.01 1.5e-02 -5.81 6.34e-09 0.03 FALSE
PL Atg101 isoform ratio NM_001007659.2 0.08 1127 0.1 6.7e-11 -6.03 1.66e-09 0.43 FALSE
PL Atg101 isoform ratio NM_001271114.1 0.08 1127 0.1 1.3e-10 6.13 8.54e-10 0.5 FALSE
PL Atg101 intron excision ratio chr7_134277496_134280164 0.06 1127 0.05 1.3e-06 -6.33 2.45e-10 0.51 FALSE
PL Atg101 intron excision ratio chr7_134277496_134280459 0.06 1127 0.06 1.6e-07 6.15 7.93e-10 0.52 FALSE
PL Galnt6 mRNA stability Galnt6 0.02 1465 0.02 2.6e-03 5.66 1.48e-08 0.21 FALSE
PL Slc4a8 mRNA stability Slc4a8 0.06 1430 0.04 1.1e-05 -5.76 8.26e-09 0.7 FALSE
pVTA Pou6f1 alternative TSS XM_063262866.1 0.04 1655 0.03 3.4e-03 -5.64 1.73e-08 0.3 FALSE
pVTA Galnt6 gene expression Galnt6 0.38 1465 0.46 4.7e-41 5.68 1.35e-08 0.14 FALSE
pVTA Krt1 gene expression Krt1 0.2 1 0.21 6.7e-17 -6.23 4.70e-10 0.54 FALSE
pVTA Krt77 gene expression Krt77 0.06 1291 0.07 2.5e-06 -5.58 2.41e-08 0.02 FALSE
pVTA Krt81 gene expression Krt81 0.04 11 0.04 4.7e-04 -6.2 5.63e-10 0.46 TRUE
pVTA Slc4a8 gene expression Slc4a8 0.11 1 0.11 2.3e-09 5.28 1.29e-07 0.02 FALSE
pVTA Atg101 isoform ratio NM_001007659.2 0.03 1127 0.02 8.0e-03 -6.38 1.73e-10 0.38 FALSE
pVTA Atg101 isoform ratio NM_001271114.1 0.04 1127 0.04 2.3e-04 6.27 3.54e-10 0.52 FALSE
pVTA Atg101 isoform ratio XM_006242324.5 0.03 1 0.03 1.8e-03 5.86 4.75e-09 0.03 FALSE
pVTA Pou6f1 isoform ratio XM_017594569.3 0.03 1655 0.02 1.3e-02 5.24 1.60e-07 0.13 FALSE
pVTA Pou6f1 isoform ratio XM_063262866.1 0.03 1655 0.01 4.2e-02 -5.41 6.35e-08 0.13 FALSE
pVTA Atg101 intron excision ratio chr7_134277496_134280164 0.03 1127 0.02 8.2e-03 -6.15 7.55e-10 0.41 FALSE
pVTA Atg101 intron excision ratio chr7_134277496_134280459 0.04 1127 0.03 1.2e-03 6.28 3.31e-10 0.48 FALSE
pVTA Bin2 intron excision ratio chr7_133652242_133652838 0.31 1 0.03 1.9e-03 6.27 3.65e-10 0.01 TRUE
pVTA Cela1 intron excision ratio chr7_133652242_133652838 0.3 1 0.03 1.8e-03 6.27 3.65e-10 0.01 FALSE
RMTg Galnt6 gene expression Galnt6 0.16 158 0.04 2.8e-02 -5.22 1.77e-07 0.27 FALSE
RMTg Krt1 gene expression Krt1 0.16 1 0.06 1.0e-02 -6.28 3.35e-10 0.06 FALSE
RMTg LOC103692984 intron excision ratio chr7_134209193_134216407 0.53 1 0.08 4.0e-03 -6.38 1.76e-10 0.05 FALSE
RMTg LOC103692984 intron excision ratio chr7_134214512_134216407 0.52 559 0.09 2.9e-03 5.85 4.79e-09 0.38 FALSE