Best TWAS P=1.674174e-07 · Best GWAS P=8.063676e-07 conditioned to 0.09640439
| # | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Brain | Usp16 | gene expression | ENSRNOG00000001598 | 0.54 | 0.09 | lasso | 14 | 0.14 | 7.6e-13 | 4.1 | 5.1 | 3.5e-07 | -0.76 | 0.69 | 0.30 | FALSE |
| 2 | LHb | N6amt1 | mRNA stability | ENSRNOG00000001603 | 0.33 | 0.10 | enet | 54 | 0.15 | 2.0e-04 | -4.6 | -5.2 | 1.7e-07 | 0.72 | 0.26 | 0.62 | TRUE |
| 3 | NAcc | Ltn1 | gene expression | ENSRNOG00000001602 | 0.25 | 0.11 | enet | 16 | 0.11 | 2.8e-08 | -4.7 | 5.1 | 3.1e-07 | -0.94 | 0.15 | 0.85 | FALSE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.