Hub : Genes

Sf3b2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Sf3b2 0.03 0.02 3.3e-03 0.01 0.02 0.01 0.01 1.7e-02 3.0e-03 1.5e-02 1.1e-02
2 NAcc gene expression Sf3b2 0.04 0.03 6.8e-05 0.02 0.03 0.03 0.03 7.2e-04 4.9e-05 5.4e-05 6.3e-05
3 NAcc mRNA stability Sf3b2 0.02 0.01 6.5e-03 0 0 0 0 3.4e-01 5.3e-02 1.9e-01 2.9e-01
4 pVTA gene expression Sf3b2 0.04 0.03 4.2e-03 0.01 0.02 0.02 0.02 3.0e-02 7.2e-03 6.0e-03 1.9e-02
5 IL gene expression Sf3b2 0.18 0.12 2.0e-03 0.04 0.04 0.02 0.06 3.5e-02 3.1e-02 1.1e-01 1.2e-02
6 Adipose gene expression Sf3b2 0.05 0.03 8.3e-05 0.04 0.03 0.04 0.04 4.1e-05 5.1e-04 7.6e-05 8.0e-05
7 Adipose mRNA stability Sf3b2 0.05 0.03 3.2e-05 0.04 0.03 0.03 0.03 6.8e-05 5.6e-04 6.7e-04 2.8e-04
8 PL mRNA stability Sf3b2 0.04 0.03 2.5e-03 0.04 0.03 0.03 0.03 9.4e-05 6.1e-04 1.8e-04 1.2e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density1.11.86.9-0.3-0.2-2.00.50.91.2-1.1-2.6
Area under the delay curve0.80.91.50.70.7-0.51.01.11.2-1.2-1.1
BMI with tail1.65.419.7-1.3-1.1-4.4-0.50.51.1-1.1-4.2
BMI without tail0.92.79.6-0.8-0.6-2.90.20.60.9-1.0-3.1
Body weight1.56.517.1-3.0-2.9-4.1-2.0-1.8-1.41.2-2.6
Weight adjusted by age1.42.12.9-1.7-1.7-1.0-1.7-1.6-1.51.5-0.1
Bone surface2.74.912.4-2.5-2.5-3.5-2.1-1.0-0.70.7-2.8
Bone volume1.11.96.2-1.3-1.2-2.5-0.7-0.10.1-0.1-2.3
Breakpoint value in progressive ratio session2.63.14.7-2.2-2.1-2.0-2.0-1.6-1.41.4-1.1
Number of licking bursts0.30.51.7-0.8-0.7-0.7-1.3-0.5-0.50.5-0.4
Context. condit. distance diff. score1.72.13.71.71.71.31.91.41.3-1.30.4
Locomotion velocity, session 10.10.10.40.00.00.3-0.3-0.4-0.40.40.7
Locomotion distance, session 10.60.72.7-0.2-0.1-1.50.20.40.6-0.6-1.6
Locomotion velocity, session 21.51.74.1-1.5-1.5-2.0-1.0-1.2-0.90.9-1.1
Locomotion distance, session 20.50.72.5-0.5-0.4-1.60.6-0.10.2-0.2-1.4
Locomotion velocity, session 30.40.51.00.60.7-0.31.00.70.8-0.8-0.6
Locomotion distance, session 30.00.00.00.10.10.00.20.00.1-0.1-0.1
Stereotopy head waving bouts, day 31.82.15.41.41.40.22.31.51.6-1.6-0.7
Stereotopy head waving duration, day 31.62.03.61.41.40.51.91.61.6-1.6-0.6
Locomotion velocity, session 71.01.11.60.91.0-0.51.31.11.2-1.2-1.1
Locomotion distance, session 70.30.40.70.30.4-0.60.80.50.7-0.6-0.8
Stereotopy head waving bouts, day 70.20.30.50.20.2-0.40.20.70.6-0.6-0.7
Stereotopy head waving duration, day 70.50.61.8-0.7-0.6-1.4-0.60.10.2-0.2-1.3
Locomotion velocity, session 80.60.71.2-1.1-1.1-0.7-0.6-1.0-0.90.9-0.1
Locomotion distance, session 80.50.72.20.80.90.01.50.80.8-0.8-0.3
Degree of sensitization distance0.40.40.90.30.3-0.60.60.60.7-0.7-0.9
Degree of sensitization stereotypy0.40.41.0-0.7-0.7-0.9-1.0-0.3-0.30.3-0.5
Conditioned locomotion1.31.52.0-1.4-1.4-1.0-1.3-1.4-1.21.3-0.1
Cocaine response after cond. corrected0.81.01.71.31.31.21.10.80.7-0.70.7
Cocaine response after cond. not corrected0.60.71.21.11.10.90.70.70.6-0.70.5
Cocaine response before conditioning0.70.81.8-1.1-1.1-0.9-1.4-0.7-0.60.6-0.5
Saline control response2.33.14.9-2.2-2.2-2.2-1.6-1.6-1.31.3-1.3
Bone: connectivity density1.82.79.1-1.4-1.3-2.9-0.70.00.4-0.4-3.0
Bone: cortical apparent density0.30.40.7-0.5-0.50.0-0.8-0.6-0.70.70.6
Bone: cortical area1.01.52.1-1.4-1.3-0.8-1.2-1.5-1.41.40.2
Bone: cortical porosity0.30.31.2-0.0-0.1-0.80.50.40.6-0.6-1.1
Bone: cortical porosity0.30.41.3-0.4-0.4-1.00.40.10.3-0.3-1.1
Bone: cortical thickness4.06.710.3-2.8-2.8-1.2-2.6-3.2-3.03.00.8
Bone: cortical thickness0.91.11.9-1.0-1.1-0.2-1.0-1.4-1.21.20.4
Bone: cortical tissue density0.40.50.9-0.7-0.6-0.1-0.9-0.8-0.90.90.6
Condit. Reinf. active minus inactive responses0.20.20.6-0.4-0.3-0.8-0.4-0.2-0.10.2-0.6
Condit. Reinf. active-inactive response ratio0.10.10.4-0.2-0.1-0.3-0.7-0.1-0.10.1-0.3
Condit. Reinf. active responses0.10.10.5-0.3-0.2-0.7-0.3-0.2-0.20.2-0.4
Condit. Reinf. inactive responses0.10.10.30.20.3-0.30.60.30.2-0.2-0.2
Incentive salience index mean0.30.31.4-0.5-0.4-1.2-0.3-0.2-0.10.1-0.8
Condit. Reinf. lever presses0.40.51.1-0.8-0.7-1.0-0.7-0.7-0.70.7-0.2
Condit. Reinf. active minus inactive responses0.10.20.40.20.2-0.10.50.60.5-0.5-0.5
Condit. Reinf. active-inactive response ratio0.30.40.70.70.70.50.60.80.6-0.60.1
Condit. Reinf. active responses0.50.72.2-0.1-0.2-0.90.50.70.8-0.8-1.5
Condit. Reinf. inactive responses0.81.03.8-0.4-0.4-1.40.30.50.9-0.9-2.0
Condit. Reinf. lever presses1.31.83.6-1.8-1.7-1.9-0.9-0.9-0.70.7-1.3
Condit. Reinf. lever reinforcers received0.40.62.2-0.5-0.5-1.10.30.40.5-0.5-1.5
Conditioned reinforcement - actives0.10.20.3-0.4-0.40.4-0.5-0.4-0.50.60.5
Conditioned reinforcement - inactives1.21.73.51.61.51.90.91.31.0-1.00.9
Conditioned locomotion4.66.011.02.92.83.32.42.11.8-1.72.0
Patch foraging indifference point 0 sec0.10.10.30.30.3-0.1-0.00.50.4-0.6-0.5
Patch foraging indifference point AUC1.92.84.3-2.1-2.1-1.3-1.7-1.8-1.61.80.1
Delay disc. indifference point, 0s delay2.12.35.01.41.5-0.02.21.61.8-1.8-0.8
Delay disc. indifference point, 16s delay0.70.81.30.91.00.30.61.11.1-1.1-0.4
Delay disc. indifference point, 2s delay0.40.40.70.60.60.00.80.70.8-0.8-0.4
Delay disc. indifference point, 24s delay0.00.00.10.30.30.40.10.00.1-0.10.1
Delay disc. indifference point, 4s delay1.01.11.90.80.9-0.21.41.11.3-1.3-0.9
Delay disc. indifference point, 8s delay0.60.71.20.60.6-0.31.10.91.0-1.0-0.9
Indifference point function ln k4.98.513.63.63.63.13.72.52.3-2.31.3
Indifference point function log k4.98.513.63.63.63.13.72.52.3-2.31.3
Patch foraging total patch changes 0 sec0.00.00.00.10.00.1-0.20.10.1-0.1-0.1
Patch foraging total patch changes 12 sec2.83.76.6-2.4-2.4-2.6-1.9-1.6-1.21.3-1.4
Patch foraging total patch changes 18 sec0.40.51.3-0.8-0.8-1.1-0.9-0.4-0.40.3-0.8
Patch foraging total patch changes 24 sec1.22.13.4-1.8-1.8-1.1-1.6-1.6-1.41.5-0.2
Patch foraging total patch changes 6 sec0.81.22.4-1.2-1.2-1.6-1.1-0.7-0.50.5-1.2
Patch foraging time to switch 0 sec1.12.27.5-1.2-1.0-2.7-1.30.10.0-0.3-2.5
Patch foraging water rate 0 sec1.94.012.92.01.93.61.60.60.3-0.22.9
Patch foraging water rate 12 sec4.28.821.13.43.24.63.41.71.5-1.42.9
Patch foraging water rate 18 sec1.72.75.72.01.92.41.71.11.1-1.01.3
Patch foraging water rate 24 sec2.83.910.92.22.13.31.70.90.9-0.62.5
Patch foraging water rate 6 sec2.73.910.82.12.03.32.20.60.4-0.42.5
Seeking ratio, delayed vs. immediate footshock0.50.61.10.50.6-0.50.21.01.0-1.1-1.0
Distance traveled before self-admin0.30.31.2-0.6-0.6-1.1-0.3-0.2-0.20.2-0.8
Distance traveled after self-admin0.20.20.3-0.6-0.6-0.5-0.4-0.3-0.40.4-0.1
Extensor digitorum longus weight5.421.131.7-5.6-5.4-5.1-4.5-4.8-4.24.3-1.6
Bone: elastic displacement0.91.03.40.40.41.70.1-0.5-0.70.71.9
Bone: elastic work1.41.83.2-1.4-1.3-0.4-1.1-1.8-1.71.70.7
Bone: endosteal estimation1.53.24.71.81.80.12.22.12.1-2.1-1.1
Bone: endosteal perimeter1.63.55.51.81.90.22.02.32.3-2.3-1.2
Epididymis fat weight2.27.611.53.43.33.32.72.72.3-2.31.7
Delta time in closed arm before/after self-admin0.10.10.2-0.2-0.2-0.40.5-0.3-0.10.1-0.4
Delta time in open arm before/after self-admin0.40.40.9-0.7-0.7-0.2-1.0-0.5-0.60.60.2
Diff in mean of infusions in LGA sessions0.70.91.4-1.1-1.1-0.6-1.2-1.0-1.01.00.0
Delay discount exponential model param0.60.71.1-0.5-0.60.4-0.8-0.9-1.01.01.0
Extinction: sum of active levers before priming1.82.04.7-1.6-1.5-2.2-1.4-0.9-0.70.7-1.6
Active lever presses in extinction session 63.53.46.6-2.1-2.1-1.4-2.6-1.9-1.81.8-0.2
Bone: final force1.42.33.7-1.9-1.9-1.9-1.1-1.5-1.31.3-0.9
Bone: final moment1.32.03.4-1.8-1.8-1.8-1.0-1.4-1.21.2-0.9
Food consumed during 24 hour testing period0.30.40.7-0.5-0.60.5-0.5-0.7-0.80.80.9
Glucose3.35.28.02.62.60.62.82.52.6-2.5-0.8
Heart weight3.14.87.12.12.2-0.22.22.52.6-2.7-2.0
Delay discount hyperbolic model param0.60.71.2-0.5-0.60.4-0.9-0.9-1.11.11.0
Intermittent access intake day 1-15 change0.40.82.60.90.91.60.20.40.1-0.01.3
Intermittent access intake escalation0.30.72.40.70.61.5-0.10.1-0.20.21.4
Intermittent access intake escalation 20.70.82.60.70.71.60.10.2-0.20.21.6
Intermitt. access day 1 inactive lever presses0.00.10.40.20.20.4-0.20.1-0.00.00.6
Intermitt. access day 15 inactive lever presses0.50.91.51.21.21.00.41.20.9-0.90.5
Intermitt. access escalation Index3.24.68.62.42.41.52.92.22.1-2.20.3
Intermittent access day 1 total infusions3.65.79.52.32.30.32.23.03.1-3.0-1.6
Intermittent access day 15 total infusions2.74.06.02.42.42.01.62.32.0-2.00.4
Intermittent access terminal intake (last 3 days)2.93.85.72.32.31.51.62.42.2-2.10.0
Intermittent access total infusions3.44.06.12.12.10.91.82.52.4-2.4-0.9
Intermittent access day 1 locomotion2.83.55.91.91.90.41.52.42.4-2.4-1.0
Intermittent access day 15 total locomotion1.83.34.82.22.21.61.32.22.0-1.90.1
Intermittent access total locomotion5.36.49.72.92.91.62.23.13.0-2.9-0.3
Intermittent access standard deviation0.40.82.41.11.11.50.60.70.5-0.40.8
Left kidney weight0.83.77.92.12.21.52.82.01.6-1.80.7
Right kidney weight0.31.42.51.21.21.61.50.90.6-0.71.4
Cocaine induced anxiety0.00.10.1-0.3-0.3-0.2-0.4-0.2-0.30.20.1
Post-drug Anxiety0.60.61.1-1.0-1.1-0.7-0.5-0.8-0.90.8-0.0
Baseline Anxiety0.20.30.4-0.6-0.6-0.30.4-0.7-0.60.60.2
Tail length0.41.52.7-1.4-1.4-0.3-0.8-1.5-1.61.40.7
Length with tail1.56.59.6-3.1-3.1-1.8-2.4-2.9-2.92.70.4
Length without tail1.85.77.9-2.8-2.8-1.6-2.6-2.8-2.62.50.3
Times rat made contact with spout0.30.31.1-0.5-0.5-1.0-0.4-0.20.0-0.0-1.1
Lifetime Intake2.83.45.21.91.90.61.92.22.3-2.2-1.0
Liver weight, left0.71.22.11.21.21.41.20.80.8-0.61.2
Liver weight, right1.62.84.52.12.11.92.01.31.3-1.30.9
Locomotor activity1.11.74.71.51.42.21.30.60.0-0.41.5
Locomotor testing distance1.32.46.01.81.72.51.90.80.2-0.61.6
Locomotor testing rearing1.42.95.12.12.01.92.31.61.1-1.50.5
Locomotion in novel chamber3.64.67.02.62.62.42.12.01.8-1.71.6
Locomotion in novel chamber post-restriction1.62.64.02.02.01.81.51.61.4-1.41.0
Fecal boli incidents, locomotor time 10.10.20.8-0.3-0.30.1-0.9-0.2-0.30.30.5
Change in fecal boli incidents, locomotor task0.40.41.30.40.4-0.30.70.60.7-0.7-1.1
Time >=10cm from walls, locomotor time 11.51.63.11.01.1-0.10.51.81.7-1.7-1.2
Bouts of movement, locomotor time 11.61.94.5-1.5-1.5-0.9-2.1-1.2-1.31.30.1
Total resting periods, locomotor time 11.11.23.5-1.2-1.2-0.8-1.9-0.9-1.01.0-0.0
Rest time, locomotor task time 10.91.12.61.21.11.60.90.60.4-0.41.4
Distance moved, locomotor task time 10.40.72.8-0.00.0-1.10.40.50.7-0.7-1.7
Vertical activity count, locomotor time 10.30.71.01.01.00.70.90.90.9-0.9-0.2
Time >=10cm from walls, locomotor time 20.00.00.1-0.2-0.1-0.1-0.30.0-0.10.10.0
Bouts of movement, locomotor time 20.30.51.2-0.8-0.8-0.9-1.1-0.5-0.40.4-0.5
Total resting periods, locomotor time 20.10.20.5-0.5-0.4-0.7-0.6-0.1-0.00.0-0.5
Rest time, locomotor task time 21.92.43.81.81.81.52.01.51.3-1.30.8
Distance moved, locomotor task time 21.21.41.9-1.4-1.4-1.0-1.2-1.4-1.31.3-0.5
Vertical activity count, locomotor time 20.50.71.2-0.5-0.50.7-0.6-1.0-1.11.10.8
Light reinforcement 10.10.10.30.40.30.50.50.30.5-0.30.1
Light reinforcement 20.30.41.30.70.71.20.20.40.3-0.30.8
Bone: marrow area1.63.65.41.91.90.22.32.22.2-2.2-1.1
Bone: maximum diameter0.20.30.6-0.6-0.7-0.2-0.8-0.6-0.60.60.3
Bone: maximum force1.93.48.1-2.2-2.1-2.8-1.7-1.3-1.01.1-1.8
Bone: maximum moment1.73.17.5-2.1-2.0-2.7-1.5-1.2-0.91.0-1.7
Mean time between licks in bursts0.10.10.3-0.4-0.5-0.3-0.2-0.5-0.30.3-0.2
Mean num. licks in bursts0.40.61.70.80.80.31.30.70.7-0.8-0.3
Cd content in liver0.70.81.21.11.11.00.11.10.9-0.90.3
Co content in liver1.21.44.11.00.92.01.0-0.0-0.20.21.9
Cu content in liver0.20.20.60.20.2-0.50.30.40.5-0.5-0.7
Fe content in liver0.30.30.5-0.6-0.6-0.0-0.7-0.7-0.70.70.3
K content in liver0.30.31.2-0.4-0.4-1.1-0.4-0.10.1-0.1-1.0
Mg content in liver0.60.61.00.80.90.10.70.91.0-1.0-0.6
Mn content in liver3.23.66.0-2.3-2.3-1.8-2.4-1.8-1.61.7-0.6
Na content in liver1.21.22.0-1.0-1.00.1-1.2-1.3-1.41.41.0
Rb content in liver2.22.63.41.81.80.91.81.81.8-1.8-0.5
Se content in liver0.10.10.10.20.20.20.20.40.3-0.3-0.1
Sr content in liver3.22.85.3-1.8-1.8-0.8-2.3-1.8-1.81.80.5
Zn content in liver0.10.10.4-0.4-0.3-0.7-0.1-0.3-0.10.1-0.5
Bone: minimum diameter1.73.24.71.61.7-0.41.82.12.2-2.2-1.6
Time in familiar zone, hab. session 10.30.30.50.50.6-0.00.30.70.7-0.7-0.3
Time in novel zone, hab. session 10.20.20.80.30.30.90.5-0.1-0.10.00.6
Total zone transitions, hab. session 10.50.71.5-0.9-0.9-1.2-0.9-0.7-0.60.6-0.6
Total locomotion distance, hab. session 10.30.40.80.80.90.20.60.70.6-0.60.0
Locomotion velocity, hab. session 10.10.10.10.30.4-0.30.30.30.3-0.3-0.2
Time in familiar zone, hab. session 20.10.10.2-0.1-0.10.3-0.4-0.3-0.30.30.4
Time in novel zone, hab. session 20.30.30.80.10.1-0.60.80.50.5-0.5-0.9
Total zone transitions, hab. session 21.82.48.7-0.5-0.4-2.5-0.20.91.2-1.1-3.0
Total locomotion distance, hab. session 21.11.52.90.70.8-1.00.71.31.5-1.4-1.7
Locomotion velocity, hab. session 21.11.52.50.90.9-0.80.71.51.5-1.5-1.6
Novel to familiar place preference ratio0.70.81.8-1.0-1.0-1.1-1.4-0.5-0.50.6-0.6
Novelty place preference0.30.41.0-0.6-0.6-0.8-1.0-0.2-0.20.2-0.5
Time in novel zone, NPP test0.20.20.5-0.5-0.5-0.7-0.7-0.0-0.00.0-0.6
Total zone transitions, NPP test1.11.64.9-1.4-1.3-2.2-0.7-0.6-0.30.4-1.7
Total locomotion distance, NPP test0.30.41.00.20.3-0.81.00.40.5-0.4-0.8
Locomotion velocity, NPP test0.20.20.60.00.1-0.80.80.30.3-0.3-0.7
Intraocular pressure0.60.93.10.60.51.8-0.40.2-0.40.21.7
Delta distance traveled before/after self-admin0.10.10.40.10.10.60.3-0.0-0.10.10.6
Delta ambulatory time before/after self-admin0.00.10.2-0.0-0.10.40.2-0.1-0.20.20.4
Parametrial fat weight3.17.210.53.23.22.23.22.92.5-2.60.6
Pavlov. Cond. lever latency0.10.20.60.40.40.80.20.30.2-0.20.4
Pavlov. Cond. magazine entry latency0.30.31.2-0.2-0.1-1.1-0.10.30.3-0.3-1.0
Pavlov. Cond. change in total contacts0.10.10.4-0.3-0.3-0.6-0.6-0.1-0.20.2-0.2
Pavlov. Cond. index score0.20.20.3-0.5-0.4-0.5-0.5-0.4-0.40.4-0.0
Pavlov. Cond. latency score0.00.10.3-0.2-0.2-0.5-0.2-0.2-0.10.1-0.2
Pavlov. Cond. lever contacts0.10.10.3-0.1-0.1-0.60.3-0.10.0-0.0-0.4
Pavlov. Cond. magazine entry number0.40.50.80.70.70.50.90.70.8-0.8-0.2
Pavlov. Cond. intertrial magazine entries0.20.20.60.30.20.80.10.0-0.20.20.8
Pavlov. Cond. lever-magazine prob. diff.0.20.30.6-0.6-0.5-0.8-0.5-0.5-0.50.5-0.2
Pavlov. Cond. response bias0.30.30.5-0.6-0.6-0.4-0.7-0.6-0.70.70.2
Pavlov. Cond. lever latency0.50.71.21.11.10.70.40.90.9-0.90.0
Pavlov. Cond. magazine entry latency2.93.57.8-2.3-2.2-2.8-1.6-1.4-1.11.1-1.8
Pavlov. Cond. change in total contacts1.01.63.3-1.7-1.6-1.8-1.2-0.8-0.80.8-1.1
Pavlov. Cond. index score1.72.34.4-1.9-1.9-2.1-1.1-1.2-1.11.1-1.2
Pavlov. Cond. latency score1.62.13.7-1.8-1.8-1.9-1.2-1.2-1.11.1-1.0
Pavlov. Cond. lever contacts0.40.61.2-1.1-1.1-0.8-0.5-0.8-0.80.8-0.2
Pavlov. Cond. magazine entry number4.86.010.73.13.03.32.42.01.7-1.71.9
Pavlov. Cond. intertrial magazine entries0.60.91.81.21.21.30.50.90.8-0.80.7
Pavlov. Cond. lever-magazine prob. diff.2.12.75.2-2.1-2.1-2.3-1.3-1.3-1.21.2-1.3
Pavlov. Cond. response bias1.31.83.4-1.8-1.7-1.8-0.8-1.0-0.90.9-1.1
Time in closed arm before self-admin0.20.30.50.60.60.20.00.70.7-0.7-0.2
Time in closed arm after self-admin0.10.10.20.50.50.20.30.20.3-0.30.1
Time in open arm before self-admin0.30.31.10.60.60.51.00.10.2-0.20.2
Time in open arm after self-admin0.00.00.0-0.2-0.2-0.0-0.1-0.2-0.20.20.1
Bone: periosteal estimation0.00.10.20.10.2-0.40.50.30.3-0.3-0.4
Bone: periosteal perimeter0.10.20.6-0.3-0.2-0.8-0.10.10.2-0.2-0.8
Bone: post-yield work2.63.812.10.10.2-2.9-0.21.61.9-1.8-3.5
Progressive ratio test 1 active lever presses0.20.20.40.40.40.10.30.60.6-0.5-0.6
Progressive ratio test 1 breakpoint0.10.20.30.30.30.10.10.50.5-0.5-0.6
Progressive ratio test 1 inactive lever presses0.00.10.10.10.10.1-0.20.30.3-0.3-0.3
Progressive ratio test 2 active lever presses1.41.72.61.41.41.11.11.61.5-1.5-0.2
Progressive ratio test 2 breakpoint1.31.52.31.41.31.11.01.51.4-1.4-0.1
Progressive ratio test 2 inactive lever presses4.37.09.73.13.12.52.43.12.8-2.80.6
Incentive Sensitization - Responses0.20.31.10.10.1-0.5-0.00.60.7-0.7-1.1
Incentive Sensitization - Breakpoint0.30.30.80.30.3-0.30.10.70.7-0.8-0.9
Sum of active levers in priming session hrs 5-65.34.97.9-2.1-2.10.2-2.8-2.3-2.62.61.9
Progressive ratio1.21.96.8-0.3-0.2-2.2-0.40.91.1-1.2-2.6
Food seeking constrained by brief footshock0.10.20.2-0.4-0.4-0.3-0.4-0.5-0.50.4-0.3
Seeking ratio, punishment vs. effort0.91.34.20.80.72.00.9-0.3-0.50.51.8
Retroperitoneal fat weight7.532.145.96.86.75.76.65.75.1-5.22.2
Reaction time number correct0.40.81.4-0.8-0.80.2-0.9-1.2-1.01.10.8
Reaction time mean minus median1.74.18.2-2.3-2.3-2.1-2.9-1.7-1.91.6-0.7
Reaction time mean minus median AUC1.23.16.8-1.9-1.8-1.2-2.6-1.7-2.01.70.0
Reaction time num false alarms0.30.40.90.50.50.80.9-0.20.20.20.9
Reaction time num false alarms AUC0.10.20.5-0.2-0.10.10.2-0.7-0.30.60.6
Reaction time trials correct on left0.40.81.4-0.8-0.80.2-0.9-1.2-1.01.10.8
Reaction time trials on left0.51.01.7-0.9-1.00.1-1.0-1.3-1.21.30.9
Reaction time mean0.10.20.8-0.3-0.2-0.3-0.90.0-0.40.1-0.0
Reaction time mean AUC0.10.10.9-0.2-0.1-0.3-0.90.1-0.20.0-0.1
Median of all reaction times0.10.10.40.40.40.2-0.10.70.3-0.5-0.1
Reaction time omissions1.72.53.8-1.8-1.8-1.5-1.9-1.6-1.81.5-0.2
Reaction time false alarm rate0.10.20.50.50.50.30.70.10.4-0.10.4
Reaction time premature initiation rate1.42.03.0-1.7-1.7-1.4-1.5-1.4-1.21.2-0.7
Reaction time premature initiations2.44.36.0-2.4-2.5-1.4-2.3-2.4-2.12.2-0.1
Std. dev. reaction times0.81.43.7-1.3-1.3-1.1-1.9-0.8-1.20.9-0.3
Reaction time trials completed0.51.01.7-0.9-1.00.1-1.0-1.3-1.21.30.9
Reaction time trials AUC0.40.71.2-0.7-0.70.2-0.7-1.1-1.01.10.8
Run reversals in cocaine runway, females0.70.73.0-0.00.1-1.20.10.40.7-0.7-1.7
Run reversals in cocaine runway, males1.21.23.8-0.0-0.11.5-0.2-1.0-1.11.21.9
Latency to leave start box in cocaine runway0.40.40.70.40.5-0.60.20.80.8-0.8-0.8
Latency to leave start box in cocaine runway, F0.20.30.50.40.4-0.50.30.60.6-0.6-0.7
Latency to leave start box in cocaine runway, M0.10.10.2-0.2-0.2-0.5-0.40.00.0-0.0-0.3
Std. dev. time between licks in bursts0.10.20.50.20.10.50.7-0.3-0.20.20.6
Total sessions with >9 infusions0.70.92.90.20.3-0.90.40.91.1-1.0-1.7
Short access day 1 total inactive lever presses1.92.53.61.81.81.31.91.81.6-1.70.2
Short access day 10 total inactive lever presses0.10.30.40.60.70.60.40.40.3-0.40.6
Short access day 1 total infusions2.12.84.31.71.70.52.01.92.1-2.0-0.7
Short access day 10 total infusions2.43.16.21.01.1-1.01.12.02.3-2.2-2.5
Short access total infusions1.62.03.31.01.0-0.51.31.61.8-1.8-1.7
Short access day 1 locomotion1.41.72.91.41.40.51.01.61.7-1.6-0.7
Short access day 10 total locomotion0.81.52.61.31.30.20.71.61.6-1.6-0.9
Short access total locomotion1.61.93.21.41.40.41.01.71.8-1.7-0.9
One hour access (0.3 mA shock)4.45.17.52.72.72.32.02.52.3-2.20.6
Compulsive drug intake1.41.73.0-1.4-1.4-0.7-0.6-1.7-1.61.60.3
One hour access (shock baseline)3.75.68.32.92.82.31.92.72.5-2.40.6
Social response proportion0.70.82.9-0.9-0.9-0.9-1.7-0.4-0.30.3-0.8
Social responses0.30.41.3-0.6-0.7-0.2-1.1-0.5-0.70.5-0.1
Social time0.30.40.9-0.7-0.7-0.2-1.0-0.7-0.70.70.2
Soleus weight2.98.613.23.63.63.63.42.52.0-2.12.0
Bone: stiffness1.42.26.3-1.7-1.6-2.5-1.2-0.7-0.40.4-1.9
Tibialis anterior weight9.030.643.7-6.6-6.5-4.4-5.9-6.1-5.85.8-0.1
Time to tail flick, vehicle, before self-admin0.20.20.8-0.1-0.1-0.7-0.30.10.2-0.2-0.9
Time to tail flick, vehicle, after self-admin0.81.04.0-0.10.0-1.60.20.60.8-0.8-2.0
Time to tail flick, test, before self-admin3.63.75.21.92.00.32.32.22.3-2.3-1.3
Time to tail flick, test, after self-admin0.10.10.7-0.3-0.30.0-0.8-0.0-0.10.10.1
Delta time to tail flick, vehicle, before/after SA0.40.41.7-0.3-0.2-1.0-0.20.30.4-0.4-1.3
Delta time to tail flick, test, before/after SA5.05.18.5-2.0-2.10.2-2.9-2.4-2.62.61.9
Tibia length1.43.96.0-2.2-2.2-0.9-2.4-2.0-2.22.20.7
Ambulatory time before self-admin0.20.41.1-0.6-0.6-1.0-0.7-0.2-0.20.2-0.7
Ambulatory time after self-admin0.20.30.60.50.4-0.10.40.80.6-0.6-0.2
Bone: tissue strength0.10.10.2-0.00.0-0.30.00.20.2-0.2-0.4
Total heroin consumption3.64.36.5-2.5-2.5-2.2-2.2-2.0-1.81.8-0.8
Bone: trabecular number1.01.66.1-0.7-0.7-2.1-0.20.50.8-0.8-2.5
Bone: trabecular spacing0.30.41.00.80.81.00.70.30.2-0.20.8
Bone: trabecular thickness0.91.11.90.80.8-0.30.71.31.4-1.4-1.3
Bone: trabecular tissue density2.43.68.02.12.12.82.21.10.7-0.72.2
Water consumed over 24 hours0.60.81.3-1.1-1.1-1.0-1.1-0.8-0.60.6-0.7
Number of responses in last shaping day0.10.10.50.10.00.30.70.00.1-0.10.3