Hub : Genes

Chrna2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Chrna2 0.63 0.13 0.0e+00 0.54 0.58 0.59 0.6 3.5e-59 7.8e-67 8.0e-68 2.1e-69
2 IL gene expression Chrna2 0.17 0.11 6.6e-03 0.05 0.05 0 0.02 2.7e-02 2.5e-02 3.1e-01 8.6e-02
3 Brain mRNA stability Chrna2 0.28 0.1 0.0e+00 0.28 0.3 0.3 0.3 8.9e-26 3.0e-28 2.4e-28 8.9e-29
4 PL gene expression Chrna2 0.14 0.07 1.3e-15 0.15 0.15 0.15 0.15 1.0e-15 4.2e-16 4.1e-16 1.9e-16
5 NAcc gene expression Chrna2 0.12 0.06 0.0e+00 0.14 0.06 0.14 0 2.4e-20 5.8e-09 2.9e-20 5.0e-02
6 BLA gene expression Chrna2 0.1 0.06 2.0e-04 0.04 0.04 0.03 0.03 3.4e-03 1.9e-03 8.6e-03 1.7e-02
7 Eye gene expression Chrna2 0.53 0.18 1.6e-06 0.27 0.33 0.29 0.3 4.5e-05 4.8e-06 2.7e-05 1.7e-05
8 Liver gene expression Chrna2 0.06 0.04 2.3e-06 0.04 0.06 0.04 0.05 8.6e-06 7.8e-07 1.1e-05 4.9e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density1.52.93.4-1.7-1.7-1.8-1.61.6-1.7-1.71.8
Area under the delay curve0.10.10.20.30.20.40.3-0.40.40.3-0.5
BMI with tail0.20.81.11.00.91.01.0-0.90.90.9-0.7
BMI without tail0.20.81.61.30.80.71.2-1.20.80.7-0.3
Body weight0.10.51.00.80.51.00.3-0.20.70.7-1.0
Weight adjusted by age0.10.31.00.20.40.80.10.20.50.5-1.0
Bone surface1.42.73.1-1.7-1.7-1.6-1.81.7-1.6-1.61.5
Bone volume1.42.83.1-1.7-1.7-1.7-1.81.7-1.6-1.61.5
Breakpoint value in progressive ratio session0.00.00.0-0.10.1-0.0-0.20.20.00.1-0.1
Number of licking bursts0.00.00.10.10.2-0.20.3-0.40.10.10.2
Context. condit. distance diff. score0.50.61.70.70.7-0.21.3-1.30.30.30.6
Locomotion velocity, session 10.50.61.2-1.0-0.5-0.7-0.91.1-0.7-0.60.4
Locomotion distance, session 11.41.83.8-1.5-1.2-0.9-1.71.9-1.3-1.20.6
Locomotion velocity, session 20.60.71.6-1.0-0.7-0.6-1.11.3-0.7-0.60.2
Locomotion distance, session 22.13.06.0-1.9-1.6-1.3-2.22.5-1.6-1.50.9
Locomotion velocity, session 32.02.32.71.61.61.51.5-1.41.51.5-1.4
Locomotion distance, session 30.50.50.80.80.80.60.9-0.90.70.7-0.4
Stereotopy head waving bouts, day 30.10.10.30.10.40.50.10.10.30.4-0.6
Stereotopy head waving duration, day 31.21.42.41.11.21.50.9-0.71.21.3-1.5
Locomotion velocity, session 70.50.51.70.3-0.0-0.70.9-1.1-0.2-0.31.3
Locomotion distance, session 71.21.54.7-0.7-1.0-1.6-0.3-0.1-1.2-1.32.2
Stereotopy head waving bouts, day 70.60.71.70.60.81.10.5-0.30.90.9-1.3
Stereotopy head waving duration, day 72.02.43.91.41.61.81.3-1.01.61.6-2.0
Locomotion velocity, session 80.30.40.70.60.80.40.7-0.60.60.7-0.5
Locomotion distance, session 80.30.50.8-0.6-0.5-0.8-0.40.6-0.7-0.70.9
Degree of sensitization distance2.93.16.5-1.4-1.8-2.1-1.10.7-1.8-1.92.5
Degree of sensitization stereotypy1.01.11.81.01.01.30.9-0.71.11.1-1.3
Conditioned locomotion0.00.00.1-0.00.3-0.20.3-0.2-0.0-0.00.3
Cocaine response after cond. corrected0.71.11.81.01.30.51.3-1.31.01.0-0.5
Cocaine response after cond. not corrected0.30.40.70.60.80.20.8-0.80.60.6-0.2
Cocaine response before conditioning1.61.92.8-1.4-1.5-1.0-1.71.7-1.4-1.40.9
Saline control response0.60.81.4-0.8-1.0-0.5-1.21.2-0.8-0.80.5
Bone: connectivity density2.94.66.2-2.2-2.0-2.5-1.91.9-2.2-2.12.3
Bone: cortical apparent density0.61.02.01.20.90.71.2-1.41.00.9-0.4
Bone: cortical area0.00.00.1-0.0-0.40.1-0.30.3-0.1-0.1-0.1
Bone: cortical porosity0.20.20.70.20.40.60.10.10.40.4-0.9
Bone: cortical porosity0.20.20.70.20.20.6-0.00.20.40.4-0.9
Bone: cortical thickness0.10.20.30.50.20.60.3-0.40.50.4-0.5
Bone: cortical thickness0.50.61.10.90.70.50.9-1.00.80.7-0.4
Bone: cortical tissue density0.81.22.31.31.00.81.3-1.51.01.0-0.5
Condit. Reinf. active minus inactive responses0.00.00.1-0.2-0.10.0-0.30.4-0.0-0.0-0.3
Condit. Reinf. active-inactive response ratio0.50.50.80.50.90.60.6-0.50.80.8-0.9
Condit. Reinf. active responses0.81.01.6-1.1-1.1-0.8-1.31.3-0.9-0.90.5
Condit. Reinf. inactive responses3.54.55.8-2.1-2.4-1.9-2.32.3-2.1-2.11.7
Incentive salience index mean0.10.10.4-0.3-0.30.0-0.60.6-0.1-0.1-0.4
Condit. Reinf. lever presses0.30.51.3-0.7-0.7-0.4-1.11.1-0.5-0.4-0.1
Condit. Reinf. active minus inactive responses0.50.81.0-1.0-0.8-0.8-0.91.0-0.9-0.90.8
Condit. Reinf. active-inactive response ratio0.10.20.30.40.50.50.5-0.40.40.4-0.3
Condit. Reinf. active responses1.01.51.6-1.3-1.2-1.2-1.21.2-1.3-1.31.2
Condit. Reinf. inactive responses2.43.53.8-1.9-1.9-1.9-1.81.7-1.9-1.91.9
Condit. Reinf. lever presses0.30.40.7-0.5-0.8-0.2-0.80.8-0.6-0.60.2
Condit. Reinf. lever reinforcers received0.71.01.1-1.0-1.0-0.9-0.91.0-1.0-1.00.9
Conditioned reinforcement - actives0.10.40.8-0.5-0.5-0.7-0.30.2-0.6-0.60.9
Conditioned reinforcement - inactives0.71.92.3-1.4-1.5-1.3-1.11.1-1.5-1.51.5
Conditioned locomotion0.30.50.90.70.70.51.0-0.90.60.6-0.3
Patch foraging indifference point 0 sec2.67.29.9-2.7-3.0-2.1-3.13.0-2.7-2.71.9
Patch foraging indifference point AUC1.63.85.21.82.01.82.3-2.31.91.8-1.5
Delay disc. indifference point, 0s delay2.02.23.1-1.8-1.5-1.4-1.61.7-1.4-1.41.0
Delay disc. indifference point, 16s delay0.10.20.40.60.30.40.6-0.60.30.3-0.2
Delay disc. indifference point, 2s delay0.50.51.2-1.1-0.6-0.5-0.91.0-0.5-0.5-0.1
Delay disc. indifference point, 24s delay0.30.50.50.70.70.60.7-0.70.70.7-0.6
Delay disc. indifference point, 4s delay1.31.41.81.11.11.31.1-1.21.21.2-1.3
Delay disc. indifference point, 8s delay0.10.20.40.60.20.50.5-0.70.50.4-0.3
Indifference point function ln k0.51.62.6-1.2-1.4-1.1-1.61.6-1.2-1.10.9
Indifference point function log k0.51.62.6-1.2-1.4-1.1-1.61.6-1.2-1.10.9
Patch foraging total patch changes 0 sec1.95.78.4-2.3-2.7-1.8-2.92.8-2.4-2.31.6
Patch foraging total patch changes 12 sec0.40.60.8-0.9-0.9-0.5-0.80.8-0.8-0.80.4
Patch foraging total patch changes 18 sec0.10.30.4-0.6-0.6-0.6-0.30.2-0.5-0.60.5
Patch foraging total patch changes 24 sec0.20.61.0-0.9-0.9-0.4-0.91.0-0.7-0.70.2
Patch foraging total patch changes 6 sec0.10.20.4-0.5-0.6-0.4-0.50.4-0.5-0.50.3
Patch foraging time to switch 0 sec0.41.52.1-1.4-1.1-1.4-1.11.0-1.2-1.21.2
Patch foraging water rate 0 sec0.10.20.60.40.40.60.10.00.50.5-0.8
Patch foraging water rate 12 sec0.00.10.20.1-0.00.3-0.30.40.10.2-0.5
Patch foraging water rate 18 sec2.14.76.22.42.02.51.8-1.82.22.2-2.3
Patch foraging water rate 24 sec0.60.91.51.20.80.81.0-1.10.90.9-0.6
Patch foraging water rate 6 sec0.81.12.50.90.91.40.6-0.41.11.1-1.6
Seeking ratio, delayed vs. immediate footshock1.82.63.7-1.8-1.6-1.6-1.51.9-1.6-1.51.2
Distance traveled before self-admin0.20.51.40.50.70.70.3-0.30.80.8-1.2
Distance traveled after self-admin0.81.42.31.01.21.40.8-0.71.21.2-1.5
Extensor digitorum longus weight8.534.145.15.66.06.54.8-4.66.06.1-6.7
Bone: elastic displacement1.01.22.0-1.3-1.1-0.9-1.31.4-1.1-1.00.6
Bone: elastic work1.31.83.4-1.4-1.4-0.9-1.71.8-1.2-1.10.5
Bone: endosteal estimation0.20.50.8-0.7-0.8-0.5-0.90.8-0.7-0.60.5
Bone: endosteal perimeter0.71.82.8-1.5-1.4-1.1-1.61.7-1.3-1.20.9
Epididymis fat weight0.20.91.3-0.9-1.1-0.9-0.80.8-1.0-1.01.1
Delta time in closed arm before/after self-admin1.61.51.8-1.3-1.2-1.3-0.91.0-1.3-1.31.3
Delta time in open arm before/after self-admin0.10.10.20.40.40.50.3-0.30.40.4-0.4
Diff in mean of infusions in LGA sessions0.00.10.3-0.1-0.00.1-0.40.50.00.1-0.4
Delay discount exponential model param0.50.60.8-0.8-0.6-0.9-0.70.8-0.8-0.80.9
Extinction: sum of active levers before priming0.60.91.1-0.8-1.1-0.8-1.00.9-1.0-1.01.0
Active lever presses in extinction session 60.20.20.40.70.40.30.5-0.70.40.30.1
Bone: final force0.00.00.10.0-0.20.1-0.30.10.00.0-0.1
Bone: final moment0.10.10.4-0.2-0.5-0.1-0.60.4-0.2-0.2-0.0
Food consumed during 24 hour testing period0.00.10.20.4-0.20.50.1-0.10.20.1-0.3
Glucose1.21.93.01.61.21.31.6-1.71.31.3-0.9
Heart weight0.50.81.2-0.9-1.0-0.9-0.60.7-1.0-1.01.1
Delay discount hyperbolic model param0.40.50.8-0.6-0.5-0.8-0.60.6-0.7-0.70.9
Intermittent access intake day 1-15 change0.10.61.0-0.9-0.7-1.0-0.50.4-0.8-0.81.0
Intermittent access intake escalation0.10.50.8-0.8-0.7-0.9-0.40.2-0.7-0.70.9
Intermittent access intake escalation 20.00.10.2-0.3-0.2-0.40.1-0.1-0.3-0.30.4
Intermitt. access day 1 inactive lever presses0.00.50.9-0.7-0.5-0.9-0.40.4-0.7-0.70.9
Intermitt. access day 15 inactive lever presses0.21.01.51.10.91.21.2-1.10.90.9-0.7
Intermitt. access escalation Index0.20.71.1-0.9-0.7-0.9-0.91.1-0.8-0.80.7
Intermittent access day 1 total infusions0.10.30.50.70.40.60.5-0.30.50.4-0.5
Intermittent access day 15 total infusions0.00.10.3-0.2-0.3-0.40.1-0.1-0.3-0.30.5
Intermittent access terminal intake (last 3 days)0.30.51.00.70.60.51.0-1.00.50.5-0.2
Intermittent access total infusions0.10.10.20.1-0.0-0.30.4-0.3-0.1-0.20.4
Intermittent access day 1 locomotion0.20.30.5-0.5-0.6-0.4-0.60.7-0.5-0.60.3
Intermittent access day 15 total locomotion0.20.81.51.00.70.81.1-1.20.80.7-0.5
Intermittent access total locomotion0.00.00.10.20.00.00.3-0.20.10.0-0.1
Intermittent access standard deviation0.42.32.81.71.41.61.6-1.61.51.5-1.4
Left kidney weight0.00.10.30.3-0.10.60.0-0.10.20.2-0.5
Right kidney weight0.10.71.4-0.7-1.1-0.1-1.21.2-0.7-0.80.2
Cocaine induced anxiety0.20.71.4-0.9-0.9-0.3-1.11.2-0.7-0.70.1
Post-drug Anxiety4.34.96.3-2.4-2.3-1.8-2.52.5-2.2-2.21.7
Baseline Anxiety0.61.01.5-1.0-0.9-1.1-0.70.7-1.0-1.01.2
Tail length0.31.52.3-1.0-1.5-1.0-1.31.2-1.2-1.31.1
Length with tail0.31.52.9-1.3-1.4-0.8-1.71.7-1.1-1.00.6
Length without tail0.10.62.00.40.51.2-0.20.20.80.8-1.4
Times rat made contact with spout0.00.00.20.2-0.1-0.00.4-0.40.0-0.00.2
Lifetime Intake0.10.10.30.30.1-0.10.5-0.40.10.10.1
Liver weight, left0.40.61.90.60.61.00.2-0.10.80.9-1.4
Liver weight, right2.34.04.82.21.92.11.9-1.92.02.1-1.9
Locomotor activity0.50.82.3-0.8-0.70.2-1.51.5-0.4-0.4-0.6
Locomotor testing distance3.38.213.0-3.2-2.9-2.3-3.53.6-2.7-2.61.7
Locomotor testing rearing3.011.017.5-3.6-3.4-2.6-4.14.2-3.1-3.02.0
Locomotion in novel chamber0.10.10.3-0.2-0.5-0.4-0.30.1-0.4-0.50.5
Locomotion in novel chamber post-restriction0.31.01.60.91.11.30.9-0.80.90.9-1.1
Fecal boli incidents, locomotor time 10.82.03.21.81.01.61.1-1.41.41.4-1.3
Change in fecal boli incidents, locomotor task0.00.00.1-0.20.2-0.30.0-0.0-0.1-0.10.2
Time >=10cm from walls, locomotor time 11.21.41.9-1.2-1.4-1.1-1.21.1-1.2-1.21.1
Bouts of movement, locomotor time 10.91.22.10.71.40.91.1-0.91.21.2-1.3
Total resting periods, locomotor time 11.82.03.21.11.81.21.5-1.31.51.5-1.4
Rest time, locomotor task time 11.01.62.61.21.61.01.5-1.21.31.3-1.0
Distance moved, locomotor task time 10.61.72.3-1.3-1.5-1.2-1.41.1-1.4-1.41.3
Vertical activity count, locomotor time 10.10.51.2-0.7-0.9-0.1-1.11.0-0.6-0.60.0
Time >=10cm from walls, locomotor time 20.10.20.40.40.40.60.2-0.30.40.4-0.4
Bouts of movement, locomotor time 20.72.43.51.51.91.41.5-1.31.71.7-1.5
Total resting periods, locomotor time 21.14.25.62.12.41.82.0-1.92.22.2-1.9
Rest time, locomotor task time 25.69.511.83.43.02.93.3-3.43.03.0-2.5
Distance moved, locomotor task time 23.64.75.5-2.3-2.4-2.0-2.32.3-2.2-2.21.8
Vertical activity count, locomotor time 20.71.73.5-1.4-1.3-0.8-1.71.9-1.1-1.10.5
Light reinforcement 10.20.91.8-0.7-1.1-0.9-0.50.5-1.0-1.01.3
Light reinforcement 20.30.71.61.00.70.41.2-1.30.70.60.0
Bone: marrow area0.20.60.9-0.8-0.9-0.6-0.90.9-0.8-0.70.6
Bone: maximum diameter0.20.40.70.60.50.80.4-0.40.60.6-0.8
Bone: maximum force0.00.10.30.1-0.10.4-0.30.20.20.2-0.5
Bone: maximum moment0.10.10.4-0.1-0.50.2-0.70.5-0.1-0.0-0.3
Mean time between licks in bursts0.95.57.2-2.6-2.2-2.7-2.02.0-2.4-2.42.4
Mean num. licks in bursts0.00.00.10.2-0.20.20.0-0.0-0.0-0.0-0.1
Cd content in liver0.40.41.20.50.51.00.10.20.60.6-1.1
Co content in liver3.64.34.82.12.22.12.0-1.82.12.1-2.1
Cu content in liver1.11.31.41.11.21.21.1-1.01.11.1-1.1
Fe content in liver2.02.52.9-1.6-1.6-1.6-1.41.3-1.6-1.61.7
K content in liver0.60.51.2-0.7-0.5-1.1-0.30.3-0.7-0.81.0
Mg content in liver1.01.11.6-1.0-1.0-1.3-0.70.8-1.1-1.11.3
Mn content in liver2.12.32.8-1.5-1.6-1.5-1.41.3-1.6-1.71.6
Na content in liver0.50.51.70.50.51.0-0.00.00.70.7-1.3
Rb content in liver0.00.00.10.0-0.1-0.20.1-0.0-0.1-0.10.3
Se content in liver4.55.37.3-2.6-2.2-2.0-2.52.7-2.2-2.21.6
Sr content in liver0.60.50.9-0.9-0.5-0.7-0.70.9-0.7-0.70.5
Zn content in liver0.91.01.5-1.1-1.0-0.9-1.11.2-1.0-1.00.8
Bone: minimum diameter0.10.10.3-0.1-0.50.3-0.60.5-0.1-0.1-0.3
Time in familiar zone, hab. session 10.10.10.2-0.3-0.2-0.4-0.30.3-0.3-0.30.4
Time in novel zone, hab. session 12.62.93.21.81.61.81.7-1.71.71.7-1.6
Total zone transitions, hab. session 10.10.10.3-0.3-0.30.1-0.50.6-0.2-0.1-0.2
Total locomotion distance, hab. session 10.91.22.1-1.3-1.1-0.9-1.31.4-1.0-1.00.6
Locomotion velocity, hab. session 12.33.25.0-2.0-1.8-1.5-2.12.2-1.7-1.61.1
Time in familiar zone, hab. session 20.30.40.70.40.80.10.7-0.90.60.7-0.2
Time in novel zone, hab. session 20.20.20.5-0.4-0.5-0.1-0.50.7-0.4-0.40.1
Total zone transitions, hab. session 20.20.20.7-0.10.20.4-0.50.60.20.3-0.8
Total locomotion distance, hab. session 20.20.30.9-0.6-0.3-0.3-0.70.9-0.3-0.3-0.1
Locomotion velocity, hab. session 20.20.20.8-0.5-0.1-0.1-0.60.9-0.1-0.1-0.4
Novel to familiar place preference ratio0.40.50.8-0.6-0.9-0.6-0.90.8-0.7-0.70.5
Novelty place preference0.60.71.1-0.8-1.0-0.7-1.00.9-0.8-0.80.6
Time in novel zone, NPP test0.50.61.0-0.8-0.8-0.7-1.00.9-0.7-0.70.5
Total zone transitions, NPP test1.42.13.4-1.6-1.3-1.2-1.71.8-1.4-1.41.0
Total locomotion distance, NPP test6.18.49.8-3.1-2.9-2.8-3.03.1-2.9-2.92.6
Locomotion velocity, NPP test4.86.97.6-2.7-2.6-2.5-2.72.8-2.6-2.62.4
Intraocular pressure1.52.53.3-1.8-1.4-1.6-1.61.6-1.6-1.51.4
Delta distance traveled before/after self-admin0.91.01.51.01.11.20.8-0.81.01.0-0.9
Delta ambulatory time before/after self-admin0.61.11.81.11.11.30.8-0.81.01.0-1.0
Parametrial fat weight2.66.07.4-2.3-2.5-2.5-2.32.1-2.5-2.52.7
Pavlov. Cond. lever latency0.00.00.1-0.10.3-0.20.3-0.3-0.0-0.00.3
Pavlov. Cond. magazine entry latency0.00.00.10.1-0.20.1-0.10.1-0.1-0.10.1
Pavlov. Cond. change in total contacts0.60.61.60.70.51.10.2-0.10.80.8-1.3
Pavlov. Cond. index score0.10.10.30.50.10.60.1-0.00.40.4-0.6
Pavlov. Cond. latency score0.00.10.10.2-0.10.3-0.10.20.20.1-0.4
Pavlov. Cond. lever contacts0.00.00.10.1-0.30.2-0.20.20.0-0.0-0.2
Pavlov. Cond. magazine entry number0.40.50.8-0.9-0.5-0.9-0.60.5-0.7-0.70.9
Pavlov. Cond. intertrial magazine entries1.11.31.7-1.2-1.2-0.9-1.31.3-1.1-1.10.8
Pavlov. Cond. lever-magazine prob. diff.0.20.30.60.60.30.70.2-0.20.50.5-0.8
Pavlov. Cond. response bias0.40.50.80.90.50.90.6-0.60.70.7-0.8
Pavlov. Cond. lever latency0.30.41.2-0.5-0.4-1.0-0.10.1-0.6-0.61.1
Pavlov. Cond. magazine entry latency0.00.00.10.1-0.30.3-0.20.1-0.0-0.1-0.2
Pavlov. Cond. change in total contacts0.71.83.21.31.11.70.9-0.91.41.4-1.8
Pavlov. Cond. index score0.30.41.10.50.31.00.2-0.20.60.6-1.1
Pavlov. Cond. latency score0.10.20.60.30.10.7-0.00.10.30.3-0.8
Pavlov. Cond. lever contacts0.30.41.10.50.31.00.1-0.10.60.5-1.1
Pavlov. Cond. magazine entry number0.10.10.20.30.50.10.4-0.40.30.3-0.0
Pavlov. Cond. intertrial magazine entries4.610.011.5-3.2-3.1-3.4-2.92.8-3.2-3.23.4
Pavlov. Cond. lever-magazine prob. diff.0.30.51.30.70.51.00.3-0.30.70.7-1.1
Pavlov. Cond. response bias0.30.41.10.50.31.00.1-0.00.50.5-1.1
Time in closed arm before self-admin0.30.40.60.60.80.60.6-0.60.70.7-0.7
Time in closed arm after self-admin0.40.50.6-0.7-0.6-0.8-0.70.7-0.7-0.70.7
Time in open arm before self-admin0.81.01.5-1.0-0.8-1.0-1.21.2-0.9-0.90.7
Time in open arm after self-admin0.00.00.1-0.2-0.0-0.2-0.20.3-0.1-0.10.1
Bone: periosteal estimation0.10.30.5-0.4-0.7-0.2-0.70.6-0.4-0.40.2
Bone: periosteal perimeter0.40.81.4-1.0-1.0-0.7-1.11.2-0.9-0.80.5
Bone: post-yield work0.81.42.81.51.01.01.4-1.71.11.0-0.5
Progressive ratio test 1 active lever presses0.71.21.91.41.00.91.3-1.31.01.0-0.7
Progressive ratio test 1 breakpoint0.81.32.11.41.11.01.3-1.31.11.1-0.7
Progressive ratio test 1 inactive lever presses0.20.71.2-0.6-0.7-1.0-0.60.7-0.8-0.81.1
Progressive ratio test 2 active lever presses0.81.11.71.30.81.01.2-1.21.00.9-0.8
Progressive ratio test 2 breakpoint0.81.01.51.20.81.01.1-1.10.90.9-0.8
Progressive ratio test 2 inactive lever presses0.10.20.40.60.20.40.6-0.60.20.20.1
Incentive Sensitization - Responses0.10.20.60.50.10.70.3-0.30.40.4-0.6
Incentive Sensitization - Breakpoint0.10.10.40.40.00.70.2-0.20.30.3-0.5
Sum of active levers in priming session hrs 5-60.10.10.40.0-0.1-0.4-0.0-0.1-0.2-0.20.6
Progressive ratio0.31.01.50.91.00.90.9-0.91.01.0-1.2
Food seeking constrained by brief footshock2.32.84.71.72.21.32.0-1.71.61.7-1.2
Seeking ratio, punishment vs. effort0.10.30.50.50.70.40.7-0.50.40.4-0.1
Retroperitoneal fat weight0.52.33.0-1.4-1.5-1.7-1.31.3-1.5-1.51.7
Reaction time number correct0.00.10.20.20.40.10.2-0.20.30.3-0.1
Reaction time mean minus median0.00.10.3-0.4-0.2-0.0-0.50.5-0.2-0.2-0.1
Reaction time mean minus median AUC0.00.00.1-0.2-0.1-0.0-0.30.4-0.1-0.10.0
Reaction time num false alarms0.30.40.9-0.6-0.7-0.4-0.90.9-0.6-0.60.4
Reaction time num false alarms AUC0.00.10.2-0.1-0.30.2-0.50.5-0.2-0.2-0.0
Reaction time trials correct on left0.00.10.20.20.40.10.2-0.20.30.3-0.1
Reaction time trials on left0.00.00.10.20.4-0.00.2-0.10.20.2-0.0
Reaction time mean0.10.10.20.20.40.50.3-0.20.30.3-0.4
Reaction time mean AUC0.10.10.30.20.40.50.2-0.10.40.4-0.6
Median of all reaction times0.20.30.50.50.60.70.6-0.50.50.5-0.6
Reaction time omissions1.32.12.6-1.3-1.4-1.6-1.41.4-1.5-1.51.6
Reaction time false alarm rate0.10.10.2-0.1-0.50.1-0.40.4-0.3-0.30.1
Reaction time premature initiation rate0.61.01.40.91.21.00.9-0.71.01.0-1.1
Reaction time premature initiations0.41.21.91.01.41.11.1-0.81.21.2-1.1
Std. dev. reaction times0.00.00.10.10.20.20.00.00.10.1-0.2
Reaction time trials completed0.00.00.10.20.4-0.00.2-0.10.20.2-0.0
Reaction time trials AUC0.00.00.10.10.3-0.00.1-0.10.20.2-0.0
Run reversals in cocaine runway, females0.30.40.5-0.6-0.6-0.7-0.30.3-0.7-0.70.7
Run reversals in cocaine runway, males6.26.810.52.72.43.22.2-2.12.62.6-2.8
Latency to leave start box in cocaine runway0.81.11.51.01.21.10.9-0.71.11.1-1.2
Latency to leave start box in cocaine runway, F2.63.24.01.81.92.01.5-1.41.81.9-2.0
Latency to leave start box in cocaine runway, M0.20.20.3-0.5-0.2-0.5-0.40.6-0.4-0.30.3
Std. dev. time between licks in bursts5.610.513.6-3.7-3.1-3.3-3.33.4-3.2-3.12.7
Total sessions with >9 infusions0.00.10.10.20.3-0.00.4-0.30.20.2-0.1
Short access day 1 total inactive lever presses1.32.63.71.71.31.71.9-1.91.51.3-1.5
Short access day 10 total inactive lever presses0.00.10.1-0.3-0.2-0.1-0.10.1-0.3-0.30.3
Short access day 1 total infusions0.40.81.30.90.90.61.1-1.10.90.8-0.7
Short access day 10 total infusions0.30.61.00.70.60.90.5-0.40.80.7-1.0
Short access total infusions0.40.50.60.80.60.80.8-0.70.70.7-0.8
Short access day 1 locomotion0.30.40.90.70.60.70.5-0.30.70.7-1.0
Short access day 10 total locomotion0.00.10.1-0.2-0.3-0.2-0.30.3-0.3-0.30.1
Short access total locomotion0.00.00.20.20.10.20.10.10.20.2-0.4
One hour access (0.3 mA shock)0.00.00.1-0.0-0.3-0.20.1-0.1-0.2-0.20.3
Compulsive drug intake1.72.63.2-1.6-1.6-1.8-1.61.6-1.6-1.61.5
One hour access (shock baseline)0.10.40.70.60.60.60.8-0.70.60.5-0.5
Social response proportion0.10.10.30.40.4-0.00.6-0.40.20.20.3
Social responses4.05.37.0-2.1-2.2-2.4-2.02.2-2.4-2.32.6
Social time0.81.21.7-1.1-1.3-0.7-1.21.3-1.2-1.10.9
Soleus weight0.92.53.11.61.81.61.5-1.41.61.7-1.6
Bone: stiffness0.30.50.80.80.60.90.5-0.60.80.8-0.8
Tibialis anterior weight5.519.026.54.24.55.03.5-3.24.54.6-5.1
Time to tail flick, vehicle, before self-admin0.20.20.4-0.3-0.6-0.3-0.40.3-0.5-0.50.6
Time to tail flick, vehicle, after self-admin1.83.75.11.82.21.72.0-1.91.92.0-1.7
Time to tail flick, test, before self-admin2.73.13.7-1.9-1.9-1.8-1.41.4-1.9-1.91.9
Time to tail flick, test, after self-admin2.22.34.9-1.3-1.3-2.0-1.00.8-1.5-1.62.2
Delta time to tail flick, vehicle, before/after SA1.61.72.61.31.50.91.6-1.61.31.3-0.8
Delta time to tail flick, test, before/after SA0.20.20.50.50.5-0.10.6-0.70.30.30.4
Tibia length2.15.98.3-2.5-2.8-1.9-2.92.8-2.3-2.31.6
Ambulatory time before self-admin0.10.30.90.40.50.60.2-0.30.60.6-0.9
Ambulatory time after self-admin1.93.04.81.61.72.21.1-1.21.81.8-2.2
Bone: tissue strength0.20.20.4-0.4-0.7-0.3-0.60.5-0.5-0.50.4
Total heroin consumption2.52.93.71.81.51.91.4-1.41.81.8-1.9
Bone: trabecular number2.03.74.5-2.0-1.9-2.1-1.71.7-2.0-2.02.0
Bone: trabecular spacing1.92.83.51.61.71.91.5-1.41.71.7-1.9
Bone: trabecular thickness0.60.81.1-0.8-1.0-0.8-0.90.8-0.9-0.80.8
Bone: trabecular tissue density0.81.41.91.11.11.30.9-1.01.21.2-1.4
Water consumed over 24 hours0.50.91.50.80.91.00.8-0.61.01.0-1.2
Number of responses in last shaping day1.01.31.81.31.01.41.0-0.91.21.1-1.3