Hub : Genes

Chrna2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IL gene expression Chrna2 0.17 0.11 6.3e-03 0.05 0.05 -0.01 0.07 3.0e-02 3.0e-02 6.1e-01 7.2e-03
2 NAcc gene expression Chrna2 0.08 0.04 9.4e-10 0.07 0.05 0.07 0 8.4e-09 2.5e-06 1.2e-08 1.3e-01
3 BLA gene expression Chrna2 0.1 0.06 1.3e-04 0.03 0.07 0.02 0.02 1.4e-02 2.0e-04 2.9e-02 2.4e-02
4 PL gene expression Chrna2 0.15 0.08 7.9e-15 0.13 0.14 0.13 0.13 1.7e-14 1.3e-14 1.8e-14 1.8e-14
5 Eye gene expression Chrna2 0.54 0.2 3.8e-06 0.3 0.3 0.27 0.29 1.5e-05 1.3e-05 4.7e-05 2.3e-05
6 Brain mRNA stability Chrna2 0.28 0.1 0.0e+00 0.28 0.3 0.29 0.29 2.1e-26 5.5e-28 1.9e-27 1.6e-27
7 Liver gene expression Chrna2 0.06 0.04 1.7e-06 0.05 0.06 0.05 0.05 1.3e-06 6.1e-07 3.8e-06 1.4e-06
8 Brain gene expression Chrna2 0.59 0.12 0.0e+00 0.55 0.59 0.58 0.6 1.8e-60 1.6e-67 3.3e-66 9.9e-69

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density1.62.73.1-1.81.5-1.7-1.5-1.7-1.71.7-1.6
Area under the delay curve0.10.10.3-0.2-0.30.30.30.30.5-0.40.5
BMI with tail0.61.82.51.6-1.41.41.51.41.1-1.21.2
BMI without tail0.10.30.7-0.3-0.1-0.40.2-0.5-0.80.9-0.6
Body weight0.10.51.00.4-0.30.60.50.71.0-0.90.8
Weight adjusted by age0.40.51.00.50.10.5-0.00.61.0-1.00.9
Bone surface1.22.03.2-1.81.5-1.4-1.5-1.4-1.21.3-1.2
Bone volume1.32.33.6-1.91.5-1.5-1.6-1.5-1.31.4-1.3
Breakpoint value in progressive ratio session0.40.40.7-0.20.7-0.5-0.8-0.5-0.80.5-0.8
Number of licking bursts0.00.10.20.2-0.40.10.30.1-0.30.2-0.1
Context. condit. distance diff. score0.60.71.80.9-1.30.21.20.1-0.90.7-0.4
Locomotion velocity, session 10.50.51.2-0.31.1-0.6-1.0-0.6-0.60.4-0.8
Locomotion distance, session 11.01.33.4-0.91.8-1.2-1.5-1.0-0.60.5-1.0
Locomotion velocity, session 20.40.51.5-0.51.2-0.6-1.1-0.5-0.20.1-0.5
Locomotion distance, session 21.62.25.3-1.32.3-1.5-2.0-1.3-0.80.7-1.2
Locomotion velocity, session 31.82.13.11.8-1.51.51.51.51.3-1.31.4
Locomotion distance, session 30.40.50.91.0-0.90.60.90.60.3-0.40.5
Stereotopy head waving bouts, day 30.10.10.30.60.10.3-0.00.30.4-0.60.2
Stereotopy head waving duration, day 31.31.52.51.2-0.61.20.81.31.5-1.61.3
Locomotion velocity, session 70.80.92.10.1-0.9-0.40.8-0.6-1.41.5-0.9
Locomotion distance, session 71.92.55.4-0.90.2-1.4-0.4-1.6-2.32.3-1.8
Stereotopy head waving bouts, day 71.11.22.11.1-0.51.00.71.11.4-1.51.2
Stereotopy head waving duration, day 72.53.14.41.8-1.11.71.41.82.0-2.11.8
Locomotion velocity, session 80.40.51.11.1-0.70.70.80.70.3-0.50.4
Locomotion distance, session 80.30.51.0-0.00.4-0.7-0.3-0.7-1.00.9-0.9
Degree of sensitization distance4.14.27.1-1.90.9-2.0-1.2-2.1-2.62.7-2.2
Degree of sensitization stereotypy1.31.42.11.1-0.81.21.01.21.4-1.41.3
Conditioned locomotion0.10.20.40.5-0.0-0.2-0.1-0.2-0.70.4-0.6
Cocaine response after cond. corrected0.81.02.11.4-1.41.01.10.90.1-0.40.4
Cocaine response after cond. not corrected0.30.41.21.1-0.90.60.60.5-0.1-0.20.1
Cocaine response before conditioning1.31.62.7-1.51.6-1.3-1.6-1.3-0.70.9-1.0
Saline control response0.40.61.2-1.11.0-0.8-0.9-0.7-0.30.5-0.4
Bone: connectivity density3.14.96.3-1.91.9-2.3-2.0-2.3-2.52.4-2.4
Bone: cortical apparent density0.70.92.30.8-1.51.01.30.90.4-0.40.8
Bone: cortical area0.10.10.3-0.4-0.10.20.20.20.6-0.30.6
Bone: cortical porosity0.30.30.90.30.20.4-0.00.50.9-0.90.6
Bone: cortical porosity0.30.30.90.10.30.3-0.00.41.0-0.90.7
Bone: cortical thickness0.20.40.8-0.0-0.60.60.70.60.8-0.50.9
Bone: cortical thickness0.30.30.90.1-0.90.60.80.60.3-0.30.6
Bone: cortical tissue density0.91.12.71.0-1.61.11.41.00.5-0.50.9
Condit. Reinf. active minus inactive responses0.10.10.1-0.30.40.0-0.30.00.4-0.30.2
Condit. Reinf. active-inactive response ratio0.50.50.90.9-0.50.80.50.80.6-0.80.6
Condit. Reinf. active responses0.60.81.6-1.31.2-0.9-1.1-0.8-0.30.4-0.5
Condit. Reinf. inactive responses3.44.16.5-2.62.3-2.2-2.1-2.1-1.41.7-1.6
Incentive salience index mean0.20.20.4-0.60.60.0-0.50.10.7-0.50.4
Condit. Reinf. lever presses0.40.51.2-1.11.1-0.4-1.0-0.30.4-0.20.1
Condit. Reinf. active minus inactive responses0.50.60.9-0.70.9-0.8-0.8-0.8-0.70.7-0.8
Condit. Reinf. active-inactive response ratio0.30.30.50.7-0.60.60.60.60.4-0.50.4
Condit. Reinf. active responses1.01.41.6-1.21.2-1.3-1.2-1.2-1.11.1-1.2
Condit. Reinf. inactive responses3.34.14.5-2.02.0-2.1-2.0-2.1-1.92.0-2.1
Condit. Reinf. lever presses0.30.41.1-1.10.9-0.5-0.7-0.50.10.1-0.1
Condit. Reinf. lever reinforcers received0.60.81.0-0.91.0-1.0-0.9-1.0-0.80.8-0.9
Conditioned reinforcement - actives0.90.91.4-0.90.5-1.0-0.5-1.0-1.11.2-1.0
Conditioned reinforcement - inactives2.02.23.9-2.01.3-1.6-1.2-1.6-1.21.5-1.4
Conditioned locomotion0.10.20.3-0.5-0.0-0.40.1-0.5-0.50.6-0.5
Patch foraging indifference point 0 sec4.06.511.0-3.33.1-2.6-2.9-2.5-1.51.8-1.9
Patch foraging indifference point AUC3.64.15.62.3-2.42.12.42.01.6-1.71.6
Delay disc. indifference point, 0s delay1.92.13.1-1.61.8-1.5-1.7-1.4-1.11.1-1.3
Delay disc. indifference point, 16s delay0.20.20.50.2-0.70.40.60.40.4-0.30.5
Delay disc. indifference point, 2s delay0.40.41.2-0.61.1-0.4-1.0-0.40.0-0.1-0.4
Delay disc. indifference point, 24s delay0.60.50.70.7-0.80.80.70.70.7-0.70.8
Delay disc. indifference point, 4s delay1.11.11.50.8-1.01.10.91.11.2-1.21.2
Delay disc. indifference point, 8s delay0.40.40.7-0.1-0.70.50.70.50.7-0.40.8
Indifference point function ln k1.01.42.5-1.41.6-1.2-1.5-1.1-0.70.8-0.8
Indifference point function log k1.01.42.5-1.41.6-1.2-1.5-1.1-0.70.8-0.8
Patch foraging total patch changes 0 sec3.35.29.6-3.12.9-2.4-2.7-2.2-1.21.5-1.5
Patch foraging total patch changes 12 sec0.40.61.2-1.10.9-0.8-0.9-0.7-0.30.4-0.6
Patch foraging total patch changes 18 sec0.30.40.8-0.90.5-0.6-0.4-0.7-0.40.6-0.5
Patch foraging total patch changes 24 sec0.40.51.2-1.01.1-0.7-1.0-0.60.00.2-0.3
Patch foraging total patch changes 6 sec0.20.20.7-0.80.5-0.5-0.4-0.5-0.20.3-0.3
Patch foraging time to switch 0 sec1.21.82.1-1.31.2-1.3-1.4-1.3-1.41.3-1.4
Patch foraging water rate 0 sec0.30.50.90.5-0.10.60.50.71.0-0.90.8
Patch foraging water rate 12 sec0.10.20.5-0.10.20.30.00.40.7-0.60.6
Patch foraging water rate 18 sec3.75.06.91.8-2.02.22.12.22.5-2.32.6
Patch foraging water rate 24 sec0.60.81.40.8-1.10.91.20.80.7-0.61.0
Patch foraging water rate 6 sec1.11.73.20.8-0.61.20.81.31.8-1.71.6
Seeking ratio, delayed vs. immediate footshock1.51.72.9-1.51.7-1.4-1.5-1.3-0.91.0-1.0
Distance traveled before self-admin0.60.61.30.7-0.30.80.30.81.1-1.10.8
Distance traveled after self-admin1.11.21.71.1-0.91.20.91.21.2-1.31.0
Extensor digitorum longus weight8.834.844.66.0-4.66.24.86.36.3-6.76.1
Bone: elastic displacement0.91.12.1-1.31.5-1.0-1.3-0.9-0.50.5-0.7
Bone: elastic work1.11.43.3-1.71.8-1.1-1.6-1.0-0.20.4-0.5
Bone: endosteal estimation0.10.20.5-0.70.5-0.4-0.5-0.4-0.20.2-0.2
Bone: endosteal perimeter0.51.12.0-1.21.4-1.0-1.3-0.9-0.60.6-0.8
Epididymis fat weight0.81.82.5-1.41.0-1.4-1.0-1.5-1.51.6-1.4
Delta time in closed arm before/after self-admin0.20.20.3-0.30.3-0.5-0.2-0.5-0.40.5-0.6
Delta time in open arm before/after self-admin0.20.20.4-0.30.2-0.4-0.2-0.4-0.70.6-0.5
Diff in mean of infusions in LGA sessions0.20.20.50.50.10.4-0.10.50.6-0.70.5
Delay discount exponential model param0.50.50.9-0.20.7-0.7-0.7-0.7-0.90.7-0.9
Extinction: sum of active levers before priming2.12.12.7-1.51.1-1.5-1.1-1.5-1.61.6-1.5
Active lever presses in extinction session 60.10.10.3-0.3-0.2-0.20.1-0.3-0.50.5-0.4
Bone: final force0.10.10.3-0.2-0.20.20.20.30.5-0.30.5
Bone: final moment0.10.10.4-0.60.10.0-0.10.10.5-0.20.5
Food consumed during 24 hour testing period0.20.30.8-0.4-0.20.20.50.20.9-0.40.8
Glucose0.91.42.91.1-1.71.11.71.10.7-0.61.0
Heart weight0.00.10.2-0.5-0.0-0.10.2-0.10.20.10.2
Delay discount hyperbolic model param0.60.61.2-0.30.6-0.8-0.6-0.7-1.10.9-0.9
Intermittent access intake day 1-15 change0.30.30.4-0.70.5-0.6-0.4-0.6-0.60.6-0.6
Intermittent access intake escalation0.10.10.1-0.20.2-0.3-0.1-0.3-0.30.3-0.3
Intermittent access intake escalation 20.00.00.0-0.10.2-0.2-0.1-0.1-0.10.1-0.2
Intermitt. access day 1 inactive lever presses0.30.30.7-0.40.3-0.5-0.5-0.5-0.80.7-0.8
Intermitt. access day 15 inactive lever presses0.10.10.20.3-0.30.30.40.30.4-0.40.4
Intermitt. access escalation Index0.00.00.10.20.10.1-0.00.1-0.1-0.1-0.1
Intermittent access day 1 total infusions0.70.81.60.5-1.20.81.30.70.8-0.60.9
Intermittent access day 15 total infusions0.10.10.50.2-0.70.30.70.20.1-0.00.2
Intermittent access terminal intake (last 3 days)1.11.22.20.8-1.51.11.51.00.9-0.81.0
Intermittent access total infusions0.30.31.00.3-1.00.41.00.30.2-0.10.3
Intermittent access day 1 locomotion0.20.20.5-0.70.2-0.5-0.1-0.5-0.20.4-0.3
Intermittent access day 15 total locomotion0.10.10.6-0.2-0.70.10.70.00.10.10.2
Intermittent access total locomotion0.10.10.4-0.6-0.1-0.20.2-0.20.00.2-0.1
Intermittent access standard deviation0.40.50.80.3-0.60.50.90.60.9-0.60.9
Left kidney weight0.82.34.20.7-1.11.31.61.42.0-1.61.9
Right kidney weight0.20.72.4-1.51.1-0.9-0.7-0.80.20.3-0.1
Cocaine induced anxiety0.20.20.5-0.50.7-0.1-0.7-0.10.5-0.40.2
Post-drug Anxiety3.03.43.9-1.81.9-1.8-2.0-1.8-1.71.7-1.8
Baseline Anxiety2.72.93.7-1.71.4-1.7-1.5-1.7-1.91.9-1.8
Tail length0.92.74.8-2.21.6-1.8-1.4-1.8-1.31.6-1.4
Length with tail0.10.51.3-1.11.1-0.6-1.0-0.60.10.1-0.2
Length without tail1.12.34.31.3-0.51.50.61.52.1-2.11.7
Times rat made contact with spout0.00.10.2-0.1-0.3-0.10.5-0.0-0.00.20.1
Lifetime Intake0.10.10.5-0.0-0.60.20.70.10.1-0.00.2
Liver weight, left5.07.99.82.4-2.62.82.92.93.0-2.73.1
Liver weight, right2.44.04.52.1-1.72.02.02.12.0-2.02.1
Locomotor activity0.50.71.7-1.11.3-0.3-1.2-0.20.9-0.70.3
Locomotor testing distance3.45.710.1-3.13.2-2.3-3.1-2.2-1.21.3-1.8
Locomotor testing rearing6.09.316.5-3.64.1-3.0-3.9-2.9-1.81.9-2.4
Locomotion in novel chamber0.00.10.2-0.2-0.30.10.30.00.2-0.00.4
Locomotion in novel chamber post-restriction0.91.11.51.2-0.91.01.11.01.1-1.11.0
Fecal boli incidents, locomotor time 11.92.13.60.5-1.61.41.41.41.7-1.31.9
Change in fecal boli incidents, locomotor task0.10.10.30.30.2-0.1-0.3-0.1-0.60.3-0.4
Time >=10cm from walls, locomotor time 11.41.42.1-1.41.2-1.2-1.1-1.2-1.01.1-1.1
Bouts of movement, locomotor time 11.31.42.31.5-1.01.31.01.31.0-1.31.0
Total resting periods, locomotor time 12.02.24.02.0-1.51.61.41.61.1-1.41.1
Rest time, locomotor task time 12.22.44.72.2-1.51.61.51.61.1-1.41.3
Distance moved, locomotor task time 11.82.03.2-1.81.3-1.4-1.4-1.4-1.21.3-1.3
Vertical activity count, locomotor time 10.60.61.6-1.01.2-0.7-1.2-0.60.10.1-0.4
Time >=10cm from walls, locomotor time 20.10.10.20.4-0.10.30.10.40.4-0.40.3
Bouts of movement, locomotor time 21.71.83.82.0-1.21.51.21.50.9-1.21.1
Total resting periods, locomotor time 23.33.55.92.4-1.92.01.92.01.4-1.71.6
Rest time, locomotor task time 27.68.712.13.0-3.43.03.52.92.5-2.42.9
Distance moved, locomotor task time 23.84.45.7-2.42.4-2.2-2.4-2.1-1.61.7-1.8
Vertical activity count, locomotor time 21.41.53.5-1.41.9-1.1-1.8-1.0-0.40.4-0.8
Light reinforcement 10.91.73.0-1.20.7-1.4-0.7-1.4-1.51.7-1.3
Light reinforcement 20.30.41.40.5-1.20.31.00.2-0.40.40.0
Bone: marrow area0.10.30.7-0.90.6-0.5-0.6-0.5-0.30.4-0.3
Bone: maximum diameter0.40.71.00.7-0.60.80.80.81.0-0.91.0
Bone: maximum force0.20.30.7-0.2-0.10.40.20.50.9-0.60.8
Bone: maximum moment0.10.20.6-0.70.20.1-0.20.20.8-0.50.7
Mean time between licks in bursts4.15.77.0-2.02.2-2.5-2.3-2.5-2.62.5-2.6
Mean num. licks in bursts0.00.00.1-0.10.1-0.10.1-0.00.3-0.10.2
Cd content in liver0.20.20.6-0.80.4-0.4-0.5-0.5-0.30.4-0.3
Co content in liver2.63.04.52.1-1.71.81.71.81.4-1.71.5
Cu content in liver1.21.42.11.5-1.21.21.21.21.1-1.21.1
Fe content in liver0.60.71.2-0.70.5-0.9-0.4-0.9-1.01.1-0.9
K content in liver0.60.60.9-0.50.5-0.7-0.5-0.8-1.00.9-0.9
Mg content in liver0.40.40.7-0.30.5-0.7-0.4-0.7-0.80.8-0.8
Mn content in liver3.03.43.9-1.61.7-1.9-1.6-1.9-1.91.9-2.0
Na content in liver0.60.61.9-0.10.70.3-0.30.51.4-1.21.0
Rb content in liver0.10.10.20.0-0.4-0.00.4-0.1-0.30.4-0.2
Se content in liver3.23.96.4-2.12.5-2.0-2.4-1.9-1.31.3-1.8
Sr content in liver1.21.11.5-0.51.1-1.1-1.0-1.1-1.11.0-1.2
Zn content in liver0.30.30.90.10.40.3-0.20.40.9-0.90.6
Bone: minimum diameter0.10.20.5-0.60.30.0-0.20.10.7-0.40.5
Time in familiar zone, hab. session 10.20.20.3-0.40.3-0.4-0.3-0.4-0.60.5-0.5
Time in novel zone, hab. session 12.82.73.21.8-1.71.71.61.71.6-1.61.6
Total zone transitions, hab. session 10.10.10.3-0.20.5-0.1-0.4-0.00.3-0.30.1
Total locomotion distance, hab. session 10.71.02.0-1.11.4-1.0-1.3-0.9-0.50.5-0.8
Locomotion velocity, hab. session 11.82.54.8-1.82.2-1.6-2.0-1.5-0.91.0-1.3
Time in familiar zone, hab. session 20.30.30.60.8-0.80.70.50.6-0.1-0.20.1
Time in novel zone, hab. session 20.20.20.3-0.60.6-0.4-0.4-0.40.10.1-0.1
Total zone transitions, hab. session 20.20.30.90.30.50.3-0.30.40.8-0.90.5
Total locomotion distance, hab. session 20.10.10.6-0.10.8-0.2-0.6-0.20.1-0.2-0.1
Locomotion velocity, hab. session 20.10.20.60.00.8-0.1-0.60.00.4-0.50.1
Novel to familiar place preference ratio0.50.51.3-1.10.8-0.7-0.9-0.7-0.40.5-0.4
Novelty place preference0.70.71.4-1.20.9-0.8-1.1-0.8-0.50.6-0.6
Time in novel zone, NPP test0.50.61.1-1.00.9-0.7-1.0-0.7-0.40.5-0.5
Total zone transitions, NPP test1.11.63.2-1.01.8-1.3-1.5-1.2-0.90.8-1.2
Total locomotion distance, NPP test5.67.69.4-2.63.1-2.9-2.9-2.8-2.52.5-2.7
Locomotion velocity, NPP test4.56.37.4-2.52.7-2.6-2.6-2.6-2.32.3-2.4
Intraocular pressure1.62.22.5-1.31.6-1.5-1.6-1.5-1.51.4-1.6
Delta distance traveled before/after self-admin1.11.21.71.3-1.11.11.11.10.8-1.00.9
Delta ambulatory time before/after self-admin0.91.01.41.2-1.01.00.91.00.8-1.00.8
Parametrial fat weight3.26.38.6-2.21.9-2.5-2.1-2.6-2.92.8-2.8
Pavlov. Cond. lever latency0.10.10.50.7-0.40.10.30.1-0.40.2-0.3
Pavlov. Cond. magazine entry latency0.00.00.1-0.2-0.10.00.30.10.3-0.10.4
Pavlov. Cond. change in total contacts1.01.02.60.3-0.30.90.50.91.6-1.41.4
Pavlov. Cond. index score0.20.30.8-0.2-0.10.40.30.40.9-0.60.8
Pavlov. Cond. latency score0.10.20.5-0.40.10.20.10.20.7-0.40.6
Pavlov. Cond. lever contacts0.10.20.5-0.40.10.10.10.20.7-0.40.6
Pavlov. Cond. magazine entry number0.50.61.2-0.40.5-0.7-0.7-0.7-1.10.9-1.1
Pavlov. Cond. intertrial magazine entries0.91.11.8-1.21.3-1.1-1.4-1.1-0.60.7-0.9
Pavlov. Cond. lever-magazine prob. diff.0.40.51.30.1-0.30.60.50.61.1-0.81.0
Pavlov. Cond. response bias0.81.01.70.5-0.70.90.90.91.3-1.01.3
Pavlov. Cond. lever latency0.70.92.1-0.30.3-0.8-0.5-0.8-1.51.2-1.2
Pavlov. Cond. magazine entry latency0.10.10.3-0.40.2-0.1-0.0-0.00.5-0.20.4
Pavlov. Cond. change in total contacts1.62.34.30.9-0.81.41.01.52.1-1.91.9
Pavlov. Cond. index score0.50.61.80.1-0.10.60.30.61.3-1.11.1
Pavlov. Cond. latency score0.30.31.1-0.20.20.30.00.31.0-0.80.7
Pavlov. Cond. lever contacts0.40.61.8-0.10.10.50.10.61.4-1.11.0
Pavlov. Cond. magazine entry number0.10.20.50.7-0.60.40.40.4-0.1-0.10.0
Pavlov. Cond. intertrial magazine entries7.69.911.5-3.02.7-3.2-2.9-3.2-3.43.3-3.3
Pavlov. Cond. lever-magazine prob. diff.0.50.71.80.3-0.20.70.40.71.4-1.11.1
Pavlov. Cond. response bias0.50.61.9-0.00.10.50.10.61.4-1.11.1
Time in closed arm before self-admin0.60.61.31.1-0.50.90.50.90.7-0.90.8
Time in closed arm after self-admin0.00.00.10.30.30.0-0.30.00.1-0.2-0.0
Time in open arm before self-admin0.10.10.4-0.30.5-0.4-0.6-0.4-0.30.2-0.3
Time in open arm after self-admin0.20.30.5-0.50.2-0.5-0.3-0.5-0.70.7-0.6
Bone: periosteal estimation0.10.10.6-0.80.3-0.2-0.3-0.20.10.10.1
Bone: periosteal perimeter0.30.40.9-0.90.9-0.7-0.8-0.6-0.30.4-0.4
Bone: post-yield work0.81.12.60.7-1.61.01.50.90.6-0.41.0
Progressive ratio test 1 active lever presses1.61.73.21.2-1.81.31.81.20.9-0.81.1
Progressive ratio test 1 breakpoint1.61.63.31.2-1.81.31.81.20.8-0.71.1
Progressive ratio test 1 inactive lever presses0.50.50.9-0.80.4-0.7-0.4-0.7-0.90.9-0.7
Progressive ratio test 2 active lever presses1.01.12.80.5-1.50.91.70.80.8-0.51.0
Progressive ratio test 2 breakpoint0.91.02.60.3-1.40.81.60.80.8-0.51.0
Progressive ratio test 2 inactive lever presses0.10.10.4-0.4-0.40.10.60.00.30.00.3
Incentive Sensitization - Responses0.30.30.6-0.3-0.50.20.80.20.7-0.30.6
Incentive Sensitization - Breakpoint0.20.20.4-0.5-0.30.10.60.10.6-0.20.5
Sum of active levers in priming session hrs 5-60.30.30.8-0.2-0.2-0.3-0.1-0.4-0.90.8-0.7
Progressive ratio0.40.50.90.5-0.30.70.60.71.0-0.90.9
Food seeking constrained by brief footshock1.62.05.62.4-1.71.41.61.30.4-0.90.7
Seeking ratio, punishment vs. effort0.30.31.21.1-0.90.50.60.4-0.2-0.10.0
Retroperitoneal fat weight0.30.91.6-0.70.4-0.9-0.5-1.0-1.31.3-1.2
Reaction time number correct0.00.10.20.4-0.20.40.20.3-0.1-0.10.1
Reaction time mean minus median0.10.10.30.10.6-0.2-0.5-0.10.0-0.1-0.2
Reaction time mean minus median AUC0.00.00.10.20.4-0.1-0.3-0.1-0.0-0.0-0.1
Reaction time num false alarms0.30.41.0-0.71.0-0.6-0.9-0.6-0.40.4-0.5
Reaction time num false alarms AUC0.10.10.3-0.50.6-0.2-0.4-0.2-0.00.1-0.0
Reaction time trials correct on left0.00.10.20.4-0.20.40.20.3-0.1-0.10.1
Reaction time trials on left0.00.00.10.3-0.20.30.10.2-0.2-0.0-0.0
Reaction time mean0.10.10.20.5-0.10.20.10.20.3-0.40.2
Reaction time mean AUC0.10.10.20.5-0.00.30.00.30.4-0.50.2
Median of all reaction times0.10.20.20.5-0.30.40.40.40.4-0.40.3
Reaction time omissions2.02.83.4-1.31.6-1.7-1.7-1.7-1.81.8-1.8
Reaction time false alarm rate0.10.10.3-0.50.5-0.4-0.3-0.3-0.00.2-0.1
Reaction time premature initiation rate0.60.81.21.1-0.70.90.90.90.8-0.90.7
Reaction time premature initiations0.71.01.61.3-0.91.11.01.10.7-1.00.7
Std. dev. reaction times0.00.00.10.40.10.1-0.00.10.2-0.20.1
Reaction time trials completed0.00.00.10.3-0.20.30.10.2-0.2-0.0-0.0
Reaction time trials AUC0.00.00.10.3-0.20.30.10.3-0.2-0.00.0
Run reversals in cocaine runway, females1.00.91.3-0.90.7-1.1-0.5-1.1-1.01.1-1.1
Run reversals in cocaine runway, males7.27.09.22.0-2.42.62.52.73.0-2.93.0
Latency to leave start box in cocaine runway1.51.62.61.6-0.81.31.11.31.2-1.41.2
Latency to leave start box in cocaine runway, F2.93.14.01.8-1.31.81.51.91.9-2.01.8
Latency to leave start box in cocaine runway, M0.90.91.2-0.51.1-1.0-0.8-1.0-1.00.9-1.0
Std. dev. time between licks in bursts7.69.111.6-2.93.4-3.1-3.4-3.0-2.62.6-3.0
Total sessions with >9 infusions0.40.40.7-0.50.3-0.6-0.4-0.6-0.80.7-0.8
Short access day 1 total inactive lever presses0.91.02.70.4-1.40.81.60.70.9-0.60.9
Short access day 10 total inactive lever presses0.30.40.8-0.40.2-0.5-0.3-0.5-0.90.8-0.7
Short access day 1 total infusions0.30.30.70.5-0.80.60.90.50.3-0.40.3
Short access day 10 total infusions0.40.40.90.0-0.50.50.70.50.9-0.70.8
Short access total infusions0.10.20.4-0.2-0.50.30.70.20.5-0.30.4
Short access day 1 locomotion0.10.10.2-0.20.10.2-0.00.20.5-0.40.3
Short access day 10 total locomotion0.70.81.5-1.20.8-1.0-0.7-1.0-0.60.8-0.8
Short access total locomotion0.80.81.6-1.30.9-1.0-0.8-1.0-0.60.8-0.8
One hour access (0.3 mA shock)0.10.10.3-0.1-0.60.20.60.20.4-0.10.4
Compulsive drug intake0.40.50.9-0.40.8-0.6-0.9-0.6-0.60.5-0.7
One hour access (shock baseline)0.40.51.00.4-1.00.71.00.60.7-0.60.6
Social response proportion0.30.30.80.9-0.70.10.60.1-0.60.4-0.3
Social responses4.25.47.6-1.82.0-2.4-2.0-2.4-2.82.7-2.5
Social time0.81.01.5-1.21.1-1.1-1.1-1.1-0.60.8-0.8
Soleus weight0.61.83.11.8-1.21.41.21.51.1-1.41.2
Bone: stiffness0.40.70.90.7-0.80.80.80.90.9-0.80.9
Tibialis anterior weight6.020.427.14.4-3.34.73.64.85.0-5.24.8
Time to tail flick, vehicle, before self-admin0.20.20.5-0.70.5-0.4-0.4-0.4-0.10.4-0.1
Time to tail flick, vehicle, after self-admin1.71.84.32.1-1.01.51.01.51.0-1.41.0
Time to tail flick, test, before self-admin0.70.71.3-1.10.8-1.0-0.7-1.0-0.60.8-0.7
Time to tail flick, test, after self-admin4.04.27.5-1.41.1-2.0-1.3-2.1-2.72.6-2.4
Delta time to tail flick, vehicle, before/after SA0.90.91.71.3-1.11.00.91.00.4-0.70.6
Delta time to tail flick, test, before/after SA0.60.51.80.3-0.3-0.40.0-0.5-1.41.1-0.9
Tibia length1.54.39.3-3.02.5-2.1-2.3-2.0-0.91.4-1.3
Ambulatory time before self-admin0.30.40.80.2-0.30.60.40.60.9-0.80.7
Ambulatory time after self-admin1.71.92.81.3-1.01.41.11.41.6-1.71.3
Bone: tissue strength0.30.30.5-0.70.6-0.6-0.6-0.5-0.30.4-0.3
Total heroin consumption1.51.82.70.9-0.91.41.01.41.7-1.51.6
Bone: trabecular number2.33.64.2-1.91.6-2.0-1.7-2.0-2.02.0-2.0
Bone: trabecular spacing2.02.63.31.7-1.21.61.31.71.7-1.81.6
Bone: trabecular thickness0.60.71.8-1.30.8-0.8-0.8-0.8-0.60.8-0.5
Bone: trabecular tissue density0.91.21.70.7-0.91.20.81.21.3-1.31.3
Water consumed over 24 hours0.60.81.30.6-0.50.80.70.91.1-1.11.0
Number of responses in last shaping day0.10.10.2-0.30.4-0.0-0.30.00.4-0.30.3