Weight in grams of the extensor digitorum longus (EDL). Located in the anterior compartment of the leg, it extends the lateral four toes and also contributes to ankle dorsiflexion.
Tags: Physiology · Muscle
Project: lionikas_2014
33 loci · 103 genes with independent associations · 1839 total associated genes
# | Chr | Start pos | End pos | # assoc genes | # joint models | Best TWAS P | Best GWAS P | Cond GWAS P | Joint genes |
---|---|---|---|---|---|---|---|---|---|
1 | chr1 | 172499757 | 174687607 | 2 | 1 | 9.18e-08 | 1.14e-06 | 1.25e-01 | Iqck |
2 | chr1 | 176862317 | 178261447 | 1 | 1 | 1.00e-07 | 3.70e-07 | 2.94e-01 | Tnrc6a |
3 | chr1 | 199748697 | 208036110 | 433 | 9 | 2.18e-10 | 1.19e-09 | 1.00e+00 | Aldh3b3 Banf1 Cfl1 Eef1g Kcnk4 Spindoc Tmem134 Znrd2 |
4 | chr2 | 36004678 | 37393436 | 1 | 1 | 1.33e-07 | 2.43e-07 | 1.17e-01 | Htr1a |
5 | chr2 | 87574354 | 88973805 | 14 | 1 | 1.69e-10 | 1.59e-10 | 6.28e-02 | Ralyl |
6 | chr2 | 90475129 | 95023945 | 42 | 4 | 7.20e-14 | 1.02e-13 | 1.00e+00 | Fabp5 Impa1 Mrps28 Tpd52 |
7 | chr2 | 97341393 | 99049575 | 2 | 1 | 1.12e-07 | 2.47e-08 | 1.00e+00 | Hnf4g |
8 | chr2 | 99427434 | 102500927 | 8 | 2 | 2.28e-08 | 1.14e-08 | 1.00e+00 | Cyp7b1 |
9 | chr2 | 225862840 | 228461478 | 14 | 1 | 2.20e-11 | 1.24e-12 | 7.62e-05 | Rap1gds1 |
10 | chr4 | 146563931 | 149353187 | 20 | 1 | 9.36e-10 | 1.18e-09 | 1.00e+00 | Tamm41 |
11 | chr5 | 54563228 | 57839987 | 8 | 1 | 2.83e-08 | 2.06e-08 | 6.96e-02 | Aco1 |
12 | chr5 | 137680740 | 138752373 | 2 | 1 | 3.38e-08 | 8.39e-04 | 3.34e-03 | Stk40 |
13 | chr6 | 128766203 | 132886544 | 180 | 8 | 1.70e-11 | 5.06e-11 | 1.00e+00 | Ahnak2 Brf1 C6h14orf180 Crip2 Pacs2 Ppp2r5c Tedc1 |
14 | chr7 | 138891 | 2057232 | 29 | 1 | 2.19e-09 | 1.45e-07 | 1.00e+00 | Cs |
15 | chr7 | 7319848 | 8715238 | 1 | 1 | 2.08e-07 | 1.59e-06 | 3.52e-01 | LOC130046242 |
16 | chr7 | 83305298 | 86293354 | 3 | 1 | 1.87e-08 | 5.88e-08 | 4.60e-27 | Med30 |
17 | chr7 | 87444313 | 88835787 | 2 | 1 | 2.81e-08 | 7.72e-10 | 1.00e+00 | LOC108351495 |
18 | chr7 | 128140829 | 129787062 | 19 | 1 | 1.06e-07 | 1.12e-07 | 1.00e+00 | Rpap3 |
19 | chr7 | 130737419 | 134728520 | 128 | 6 | 6.54e-11 | 9.69e-09 | 1.00e+00 | Acvrl1 Atg101 Csad Dazap2 Krt71 Tfcp2 |
20 | chr8 | 69484387 | 75537324 | 100 | 11 | 1.04e-09 | 1.65e-09 | 1.00e+00 | Aqp9 Ccpg1 LOC103693133 LOC103693140 LOC120094195 Myzap Nedd4 Pigb Prtg Tex9 Wdr72 |
21 | chr9 | 43257854 | 50043612 | 106 | 6 | 1.79e-11 | 8.08e-12 | 1.00e+00 | Col5a2 Inpp1 LOC120094677 Mrps9 Nck2 RGD1310553 |
22 | chr10 | 58773413 | 61528656 | 28 | 2 | 2.16e-08 | 2.35e-08 | 1.00e+00 | Crk Mettl16 |
23 | chr10 | 81233874 | 86075305 | 197 | 10 | 9.22e-11 | 1.45e-10 | 1.00e+00 | Fbxl20 Ikzf3 LOC108352132 Med1 Rapgefl1 Rara Smarce1 Thra |
24 | chr10 | 87348412 | 89837033 | 11 | 1 | 7.89e-08 | 1.74e-07 | 1.00e+00 | Acbd4 |
25 | chr10 | 90321052 | 92351292 | 4 | 1 | 2.59e-09 | 3.37e-07 | 5.21e-01 | Psmc5 |
26 | chr12 | 22091 | 758485 | 1 | 1 | 2.11e-07 | 3.56e-07 | 1.00e+00 | Brca2 |
27 | chr12 | 981381 | 4653252 | 27 | 5 | 3.38e-09 | 7.06e-08 | 1.00e+00 | LOC102552452 Snapc2 Trappc5 Zfp958 |
28 | chr14 | 8430379 | 9913184 | 5 | 1 | 4.74e-08 | 1.86e-07 | 4.10e-01 | Lin54 |
29 | chr14 | 11769103 | 13161028 | 2 | 1 | 8.57e-09 | 6.27e-07 | 5.70e-03 | Paqr3 |
30 | chr14 | 16613137 | 22686240 | 153 | 7 | 3.34e-16 | 1.55e-15 | 1.00e+00 | Alb Gc Slc4a4 Ugt2b-ps1 Ugt2b37 |
31 | chr15 | 35796833 | 43041493 | 152 | 7 | 3.08e-13 | 3.18e-13 | 1.00e+00 | Bnip3l Gucy1b2 LOC108352941 Prss55 Stmn4 |
32 | chr15 | 43602320 | 46641712 | 121 | 6 | 4.11e-19 | 5.45e-13 | 1.00e+00 | Dmtn Fhip2b Lgi3 LOC120097030 Phyhip Sorbs3 |
33 | chr15 | 46891340 | 49413227 | 23 | 1 | 4.16e-12 | 7.82e-13 | 4.55e-02 | LOC102554611 |
Tissue | RNA modality | # hits | % hits/tests | Avg chisq |
---|---|---|---|---|
Adipose | alternative polyA | 62 | 1.7 | 3.87 |
Adipose | alternative TSS | 47 | 1.4 | 3.74 |
Adipose | gene expression | 150 | 1.6 | 4 |
Adipose | isoform ratio | 77 | 1.7 | 3.86 |
Adipose | intron excision ratio | 34 | 1.1 | 3.27 |
Adipose | mRNA stability | 71 | 1.6 | 3.96 |
BLA | alternative polyA | 29 | 1.3 | 4.08 |
BLA | alternative TSS | 40 | 2.1 | 4.12 |
BLA | gene expression | 121 | 1.8 | 4.06 |
BLA | isoform ratio | 66 | 2.2 | 4.17 |
BLA | intron excision ratio | 50 | 1.5 | 3.7 |
BLA | mRNA stability | 44 | 1.8 | 4.11 |
Brain | alternative polyA | 62 | 1.7 | 3.91 |
Brain | alternative TSS | 68 | 1.7 | 4.07 |
Brain | gene expression | 164 | 1.6 | 3.95 |
Brain | isoform ratio | 105 | 1.9 | 4.13 |
Brain | intron excision ratio | 107 | 1.8 | 3.96 |
Brain | mRNA stability | 98 | 1.8 | 3.94 |
Eye | alternative polyA | 3 | 1 | 4.14 |
Eye | alternative TSS | 6 | 1.5 | 4.48 |
Eye | gene expression | 25 | 2 | 3.9 |
Eye | isoform ratio | 7 | 1.2 | 3.63 |
Eye | intron excision ratio | 26 | 2.8 | 4.13 |
Eye | mRNA stability | 7 | 1.9 | 3.92 |
IL | alternative polyA | 18 | 1.6 | 4.28 |
IL | alternative TSS | 13 | 2 | 3.6 |
IL | gene expression | 66 | 1.6 | 3.85 |
IL | isoform ratio | 22 | 1.8 | 3.96 |
IL | intron excision ratio | 17 | 1.5 | 3.7 |
IL | mRNA stability | 29 | 2.1 | 4.25 |
LHb | alternative polyA | 22 | 2 | 4.11 |
LHb | alternative TSS | 17 | 2.8 | 4.06 |
LHb | gene expression | 62 | 1.7 | 3.87 |
LHb | isoform ratio | 28 | 2.2 | 4.01 |
LHb | intron excision ratio | 11 | 0.9 | 3.18 |
LHb | mRNA stability | 16 | 1.3 | 4.02 |
Liver | alternative polyA | 38 | 1.4 | 3.92 |
Liver | alternative TSS | 40 | 1.5 | 3.69 |
Liver | gene expression | 148 | 1.9 | 3.91 |
Liver | isoform ratio | 65 | 1.7 | 3.78 |
Liver | intron excision ratio | 101 | 2.1 | 3.9 |
Liver | mRNA stability | 67 | 2.2 | 3.99 |
NAcc | alternative polyA | 57 | 1.8 | 3.95 |
NAcc | alternative TSS | 47 | 1.7 | 4.02 |
NAcc | gene expression | 136 | 1.6 | 3.95 |
NAcc | isoform ratio | 78 | 1.8 | 4.1 |
NAcc | intron excision ratio | 81 | 1.6 | 3.84 |
NAcc | mRNA stability | 66 | 2 | 4.15 |
OFC | alternative polyA | 15 | 1.3 | 3.94 |
OFC | alternative TSS | 10 | 1.4 | 3.84 |
OFC | gene expression | 76 | 1.8 | 3.94 |
OFC | isoform ratio | 27 | 2 | 3.95 |
OFC | intron excision ratio | 23 | 2 | 3.92 |
OFC | mRNA stability | 17 | 1.3 | 4.01 |
PL | alternative polyA | 54 | 1.6 | 3.95 |
PL | alternative TSS | 83 | 2.5 | 4.28 |
PL | gene expression | 149 | 1.6 | 3.99 |
PL | isoform ratio | 97 | 2 | 4.16 |
PL | intron excision ratio | 85 | 1.6 | 3.79 |
PL | mRNA stability | 82 | 2.1 | 4.04 |
pVTA | alternative polyA | 26 | 1.6 | 3.81 |
pVTA | alternative TSS | 27 | 2 | 4.26 |
pVTA | gene expression | 86 | 1.6 | 3.92 |
pVTA | isoform ratio | 48 | 2.1 | 4.03 |
pVTA | intron excision ratio | 51 | 1.7 | 3.8 |
pVTA | mRNA stability | 33 | 2.3 | 4.15 |
RMTg | alternative polyA | 9 | 1.5 | 3.7 |
RMTg | alternative TSS | 4 | 0.8 | 2.93 |
RMTg | gene expression | 36 | 2 | 4.05 |
RMTg | isoform ratio | 8 | 1.2 | 3.45 |
RMTg | intron excision ratio | 16 | 2 | 3.47 |
RMTg | mRNA stability | 10 | 1.6 | 4.02 |