Extensor digitorum longus weight

Weight in grams of the extensor digitorum longus (EDL). Located in the anterior compartment of the leg, it extends the lateral four toes and also contributes to ankle dorsiflexion.

Tags: Physiology · Muscle

Project: lionikas_2014

30 loci · 94 genes with independent associations · 563 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	1	171727837	174685359	3	1	1.67e-07	9.37e-07	2.49e-65	Rps15a
2	1	176946412	178345186	1	1	3.12e-08	3.70e-07	1.39e-02	Tnrc6a
3	1	199398809	208295455	132	8	3.51e-10	1.19e-09	1.00e+00	Tpcn2 Ganab Sf3b2 Cfl1 Ppp2r5b Tmem134 Ctsw Atg2a
4	2	86361148	88973805	2	1	3.24e-10	1.59e-10	1.00e+00	Ralyl
5	2	89673058	95023945	16	1	1.83e-13	1.02e-13	1.00e+00	Zfp704
6	2	97341393	99049575	2	1	8.41e-08	2.47e-08	1.00e+00	Hnf4g
7	2	99787494	102500927	6	1	1.87e-08	1.14e-08	1.16e-01	Cyp7b1
8	2	225972996	228461478	7	1	8.29e-10	1.24e-12	1.14e-04	Rap1gds1
9	4	146441482	149011707	7	1	1.47e-09	1.18e-09	1.44e-01	Slc6a11
10	5	54563228	57839987	7	2	8.19e-08	2.06e-08	8.77e-02	Ddx58 Aptx
11	6	129055047	132888501	37	4	3.43e-12	5.06e-11	1.00e+00	Siva1 Inf2 Cep170b Tedc1
12	7	29535	2057232	31	4	1.47e-07	1.45e-07	1.00e+00	Ikzf4 Rab5b Dnajc14 Sarnp
13	7	16845355	16970279	1	1	4.62e-36	NaN	NA	ENSRNOG00000064438
14	7	83305298	85971312	3	2	6.82e-08	5.88e-08	0.00e+00	Med30 ENSRNOG00000043390
15	7	87430397	88835787	2	1	4.17e-08	7.72e-10	1.00e+00	Has2
16	7	127692699	129997098	8	2	7.54e-08	1.12e-07	1.00e+00	Slc48a1 Rapgef3
17	7	130474807	134497678	35	6	5.98e-11	9.69e-09	1.00e+00	Dazap2 Scn8a Csad Krt80 Galnt6 Krt71
18	8	69336832	75537324	30	6	2.74e-09	1.65e-09	1.00e+00	Rsl24d1 Ccpg1 Unc13c Myzap Nedd4 Pigb
19	9	41500976	42900083	1	1	3.39e-07	2.58e-07	1.00e+00	Map4k4
20	9	44247541	50043612	31	10	9.30e-12	8.08e-12	1.00e+00	Wdr75 Osgepl1 Tpp2 Nemp2 Mrps9 RGD1310553 Fhl2 Nck2 Ercc5 Ormdl1
21	10	58773413	61500745	15	1	2.72e-08	2.35e-08	1.00e+00	Crk
22	10	81422075	86251828	46	8	1.01e-11	1.45e-10	NaN	Krt15 Rpl19 Thra Rara Igfbp4 Srcin1 Ormdl3 Stard3
23	10	87148755	89011911	6	3	8.89e-08	1.74e-07	1.00e+00	Gfap Acbd4 Arhgap27
24	10	90210853	92351292	6	1	4.41e-09	3.37e-07	3.90e-01	Map3k3
25	12	27006	4653252	12	6	1.01e-08	7.06e-08	1.00e+00	Trappc5 Cers4 N4bp2l2 Insr Pet100 Zfp958
26	14	8196668	10268633	7	1	7.38e-08	1.86e-07	4.71e-01	Lin54
27	14	16470695	22686240	33	5	1.63e-16	1.55e-15	NaN	Alb Gc Slc4a4 Rufy3 Adamts3
28	15	35796833	43041493	41	7	3.82e-13	3.18e-13	1.00e+00	Dleu7 Gucy1b2 ENSRNOG00000009522 Msra Gulo Chrna2 Ptk2b
29	15	43349498	46640839	28	6	2.31e-13	5.45e-13	1.00e+00	Sorbs3 Phyhip Lgi3 Nudt18 R3hcc1 Egr3
30	15	47167781	49440043	7	1	2.06e-11	7.82e-13	4.11e-03	Fndc3a

Pleiotropic Associations

Trait	Chi² ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	Corr	Corr P	Genes
BMI with tail	7.07	88	21	22.3	1	7.57e-244	Naca Ptges3 Atp5f1b Rbms2 Cnpy2 Dazap2 Med30 Pa2g4 Erbb3 Ikzf4 Suox Rab5b Tmem198b Dnajc14 Cd63 Bloc1s1 Itga7 Ice2 Znrd2 Nab1 Banf1 Eif1ad Ovol1 Dpf2 Snx15 Arl2 Nrxn2 Slc22a12 Rps6ka4 Kcnk4 Gpr137 Bad Macrod1 Otub1 Rtn3 Atl3 Flrt1 Dgka Rnf41 Scyl1 Fam89b Ext1 Snx32 Hibch AC128207.1 Coq10a Ormdl2 Sarnp Slc25a45 Stat2 Smarcc2 Dpp3 Gls2 Timeless Prim1 Galnt6 Zc3h10 ENSRNOG00000043390 Rab27a Rsl24d1 Ccpg1 Baz2a Myl6 Adam10 Khdc3 AC142458.1 Wdr72 Prtg Hdac7 Bnip2 Ehbp1l1 Gls Unc13c Dnaaf4 Fam81a Myzap Nedd4 Pigb Tex9 Rnf111 Esyt1 Atf1 Aqp9 Myo1e ENSRNOG00000062455 ENSRNOG00000065465 ENSRNOG00000065802 Pygo1
BMI without tail	17.18	9	2	2.1	0.46	1.27e-02	Snx16 Tpd52 Mrps28 RGD1559600 ENSRNOG00000049075 Zfp704 Zbtb10 Hey1 ENSRNOG00000064438
Body weight	6.03	148	47	50	0.97	0.00e+00	Stxbp2 Trappc5 Snapc2 Timm44 Elavl1 Cers4 N4bp2l2 Cwc25 Lasp1 Cacnb1 Dazap2 Rpl19 Stac2 Med30 Fbxl20 Med1 Cdk12 Erbb2 Ikzf3 Zpbp2 Thra Nr1d1 Tbx21 Msl1 Casc3 Snx16 Rara Asb8 Ice2 Igfbp4 Srcin1 Krt12 Pcgf2 Znrd2 Metap1 Pip4k2b Tspan5 Rap1gds1 Kmt5b Slc22a8 Taf6l Ttc9c Slc11a2 Bbs1 B3gat3 Peli3 Slc29a2 Eef1g Brms1 Yif1a Rab3il1 Fads3 Sf3b2 Banf1 Eif1ad Sart1 Fibp Efemp2 Mus81 Cfl1 Ovol1 Frmd8 Dpf2 Pola2 Tm7sf2 Vps51 Snx15 Arl2 Ppp2r5b Nrxn2 Slc22a12 Rps6ka4 Prdx5 Kcnk4 Gpr137 Bad Vegfb Fermt3 Macrod1 Otub1 Rtn3 Atl3 Flrt1 Slc22a20 Arhgap23 Pced1b Scyl1 Fam89b Ext1 Snx32 Ctsw Cdc42bpg Tsga10ip Rapgefl1 Arhgef18 Ppp1r1b ENSRNOG00000028430 Insr Ormdl3 Slc25a45 Dpp3 Galnt6 Krt26 Arl5c Fbxo47 Cisd3 Stard3 ENSRNOG00000043390 Ehd1 Epop ENSRNOG00000048337 Pet100 Gjd3 Eif4e Slc48a1 Tmem106c Mllt6 Rpap3 Ccpg1 Adam10 Majin Aldh1a2 Hdac7 Bnip2 Ehbp1l1 Dip2b Fam81a Ahnak Myzap Pfkm Nedd4 Socs7 N4bp2l1 Gcnt3 Pigb Rapgef3 Rnf111 Atf1 Mindy2 Aqp9 Myo1e ENSRNOG00000064438 Zfp958 Pygo1 Tcap Lrrc3c ENSRNOG00000069975 ENSRNOG00000070737
Epididymis fat weight	87.61	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Left kidney weight	13.03	14	11	11.7	0.61	2.62e-04	Stxbp2 Trappc5 Snapc2 Timm44 Elavl1 Cers4 N4bp2l2 Tnrc6a Arhgef18 Insr Pet100 N4bp2l1 ENSRNOG00000064438 Zfp958
Right kidney weight	11.43	14	9	9.6	0.55	1.81e-03	Stxbp2 Trappc5 Snapc2 Timm44 Elavl1 Cers4 N4bp2l2 Tnrc6a Arhgef18 Insr Pet100 N4bp2l1 ENSRNOG00000064438 Zfp958
Tail length	12.01	19	13	13.8	0.56	4.08e-04	Stxbp2 Trappc5 Snapc2 Timm44 Elavl1 Cers4 N4bp2l2 Snx16 Cdca4 Brf1 Arhgef18 Insr Cep170b Pet100 N4bp2l1 ENSRNOG00000064438 ENSRNOG00000065195 Zfp958 Tedc1
Length with tail	9.47	63	38	40.4	0.92	3.07e-119	Stxbp2 Trappc5 Snapc2 Timm44 Elavl1 Cers4 N4bp2l2 Alb Gc Cwc25 Lasp1 Cacnb1 Rpl19 Crip2 Tmem121 Cdk12 Tbx21 Srcin1 Klc1 Xrcc3 Zfyve21 Ppp1r13b Pcgf2 Pip4k2b ENSRNOG00000013097 Tmem179 Kif26a Clba1 Cdca4 Gpr132 Jag2 Nudt14 Brf1 Btbd6 Pacs2 Arhgap23 Adamts3 Crip1 Arhgef18 Tex22 ENSRNOG00000028430 Pld4 Akt1 Siva1 Inf2 Insr Cep170b Cisd3 ENSRNOG00000039504 Stard3 Rd3l Adssl1 Epop Pet100 Mllt6 Tdrd9 N4bp2l1 ENSRNOG00000065195 Zfp958 ENSRNOG00000067921 Tcap Tedc1 ENSRNOG00000070737
Length without tail	13.63	19	11	11.7	0.99	7.49e-42	Stxbp2 Trappc5 Snapc2 Timm44 Elavl1 Cers4 N4bp2l2 Asb8 Arhgef18 Pet100 Slc48a1 Tmem106c Rpap3 Hdac7 Pfkm N4bp2l1 Rapgef3 ENSRNOG00000064438 Zfp958
Liver weight, left	23.57	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Parametrial fat weight	26.35	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Retroperitoneal fat weight	6.16	83	0	0	-1	0.00e+00	Znrd2 Tpcn2 Ighmbp2 Cpt1a Ppp6r3 Lrp5 Kmt5b Tcirg1 Ndufs8 Aldh3b1 Gstp1 Actn3 Bbs1 Peli3 Slc29a2 Brms1 Yif1a Cnih2 Klc2 Pacs1 Sf3b2 Cst6 Banf1 Eif1ad Sart1 Drap1 Efemp2 Mus81 Cfl1 ENSRNOG00000020700 Ltbp3 Frmd8 Dpf2 Ccnd1 Fau Tm7sf2 Vps51 Sac3d1 Snx15 Arl2 ENSRNOG00000021018 Ppp2r5b Men1 Map4k2 Sf1 Nrxn2 Rps6ka4 Prdx5 Esrra Kcnk4 Gpr137 Bad Plcb3 Macrod1 Otub1 Naa40 Atl3 Tmem134 Aip Fam89b Ccdc88b Ctsw Cdc42bpg Tsga10ip Gal3st3 Slc25a45 Dpp3 Ehd1 Rbm14 Cdca5 Ccs NEWGENE_1310680 Zfpl1 Rin1 ENSRNOG00000050741 Majin AC126581.1 Sptbn2 Atg2a Rbm4b ENSRNOG00000062876 Aldh3b2 Rab1b
Intraocular pressure	29.37	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Soleus weight	12.78	71	31	33	0.87	2.77e-69	Enoph1 Ptges3 Atp5f1b Alb Rbms2 Cnpy2 Pa2g4 Erbb3 Ikzf4 Suox Rab5b Tmem198b Dnajc14 Cd63 Bloc1s1 Itga7 Ice2 Bbs1 Slc29a2 Brms1 Cnih2 Dgka Rnf41 Adamts3 AC128207.1 Coq10a Ormdl2 Sarnp Stat2 Smarcc2 Gls2 Timeless Prim1 Zc3h10 Ccs Rab27a Rsl24d1 Ccpg1 Baz2a Myl6 Adam10 Khdc3 AC142458.1 Wdr72 Aldh1a2 Prtg Bnip2 Mir628 Unc13c Dnaaf4 Fam81a Myzap Tcf12 Sptbn2 Nedd4 Gcnt3 Pigb Tex9 Rfx7 Rnf111 Esyt1 Mindy2 Rbm4b Aqp9 Myo1e ENSRNOG00000062455 ENSRNOG00000064438 ENSRNOG00000065465 ENSRNOG00000065802 Pygo1 ENSRNOG00000069347
Tibialis anterior weight	10.03	342	306	325.5	0.98	0.00e+00	Phf24 Stxbp2 Trappc5 Snapc2 Timm44 Elavl1 Cers4 N4bp2l2 Mettl7a Rap1gap2 Gc Rtn4rl1 Rpa1 Slc4a4 Serpinf1 Dck Rufy3 Slc43a2 Myo1c Dazap2 Scn8a Aco1 Ddx58 Aptx Smu1 Atg101 ENSRNOG00000008057 Krt86 Pdlim2 Sorbs3 Hnf4g Dleu7 Rnaseh2b Gucy1b2 Trim35 ENSRNOG00000009522 Dpysl2 Cyp7b1 Ppp3cc Fam124a Pnma2 Bnip3l Slc39a14 Piwil2 Ints6 Snx16 Polr3d Wdfy2 Ythdf3 Ice2 Phyhip Fabp4 Bmp1 Igfbp6 Mob1b Trmt10a Ppp2r2a Lgi3 Ralyl Hr Tpd52 Csad Nudt18 Pinx1 Fhip2b Sox7 Dmtn Msra Rarg Znrd2 Fgf17 Metap1 Kctd9 Pde7a Kif13b Nudt2 Armc1 Hmbox1 Tpcn2 Ighmbp2 Ints9 Extl3 Nefl Nefm Dok2 Fbxo16 Gfra2 Pnoc Cpt1a Elp3 Scara5 Fndc3a Map3k12 Atp5mc2 Slc25a37 Ppp6r3 Lrp5 Tspan5 Esco2 Ccdc25 Rap1gds1 Scara3 Entpd4 Clu Gulo Loxl2 R3hcc1 Kmt5b Chmp7 Tcirg1 Ephx2 Rhobtb2 Chrna2 Ndufs8 Aldh3b1 Unc93b1 Egr3 Bin3 Doc2g Slc22a8 Slc22a6 Gstp1 Ccar2 Rps15a Slc3a2 Pitpnm1 Stx5 Nxf1 Tmem223 Pc Taf6l Ttc9c Slc11a2 Ubxn1 RGD1597339 Ctsf Ganab Actn3 Bbs1 Rom1 B3gat3 Mta2 Peli3 Slc29a2 Tut1 Eef1g Brms1 Yif1a Asrgl1 Cnih2 Klc2 Rab3il1 Pacs1 Fads3 Sf3b2 Cst6 Banf1 Eif1ad Sart1 Drap1 Fibp Efemp2 Mus81 Ppp1r32 Sdhaf2 Cfl1 Cpsf7 Ovol1 Tmem216 ENSRNOG00000020700 Ltbp3 Frmd8 Dpf2 Pola2 Ccnd1 Ccdc86 Fau Tm7sf2 Vps51 Sac3d1 Snx15 Arl2 ENSRNOG00000021018 Ppp2r5b Men1 Map4k2 Sf1 Nrxn2 Slc22a12 Rps6ka4 Prdx5 Esrra Kcnk4 Gpr137 Bad Plcb3 Vegfb Fermt3 Macrod1 Otub1 Naa40 Rtn3 Atl3 Plaat3 Mtfr1 Bhlhe22 Tmem134 Aip Zc2hc1a Flrt1 tGap1 Fth1 Slc22a20 Pmp2 Stpg2 Scyl1 Fam89b Dock5 Tnrc6a Ext1 Ccdc88b Crk Krt80 Ints5 Syt7 Snx32 Smyd4 Ctsw Sgsm2 Cdc42bpg Adamts3 Tsga10ip Ptk2b Arhgef18 Gal3st3 Slc4a8 Krt1 Insr Slc25a45 Dpp3 Krt4 Tfcp2 Mrps28 Adh7 Galnt6 Pcbp2 Krt77 Tnfrsf10b Fabp12 Prr13 RGD1559600 ENSRNOG00000043390 Ehd1 Uqcc3 Rbm14 Cdca5 Fzd3 Prss55 ENSRNOG00000047632 Ccs ENSRNOG00000048337 ENSRNOG00000049075 Krt71 NEWGENE_1310680 Pet100 Zfpl1 Rin1 Gde1 ENSRNOG00000050741 Eif4e Rab27a Rsl24d1 Stmn4 Ccpg1 Soat2 Adam10 Majin Zfp704 Khdc3 AC142458.1 Wdr72 Aldh1a2 Prtg Bnip2 Ehbp1l1 Dip2b Mir628 Unc13c Dnaaf4 Inpp5k Fam81a Ahnak Myzap Tcf12 AC126581.1 Sptbn2 Nedd4 N4bp2l1 Gcnt3 Scarf1 Pigb Tex9 Doc2b Rfx7 Atg2a Rnf111 Atf1 Pag1 Mindy2 Rph3al Rbm4b Zbtb10 Aqp9 Myo1e ENSRNOG00000062795 ENSRNOG00000062876 Hey1 ENSRNOG00000064121 ENSRNOG00000064438 ENSRNOG00000065340 Zfp958 ENSRNOG00000065465 ENSRNOG00000065802 Pygo1 ENSRNOG00000066286 ENSRNOG00000066523 ENSRNOG00000066793 ENSRNOG00000067366 Slc10a5 ENSRNOG00000067974 Aldh3b2 ENSRNOG00000068527 Krt6a ENSRNOG00000068784 ENSRNOG00000069347 Smim27 ENSRNOG00000069975 ENSRNOG00000070294 Krt6a ENSRNOG00000070558 ENSRNOG00000070769 Rab1b
Tibia length	7.28	3	0	0	0.22	6.77e-01	Fndc3a Pet100 ENSRNOG00000064438
Number of licking bursts	155.04	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Food consumed during 24 hour testing period	17.5	1	0	0	0	1.00e+00	ENSRNOG00000064438
Times rat made contact with spout	75.14	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Mean time between licks in bursts	54.91	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Mean num. licks in bursts	164.17	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Std. dev. time between licks in bursts	177.72	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Indifference point 0 sec	16.4	2	1	1.1	0	1.00e+00	Bnip3l ENSRNOG00000064438
Indifference point AUC	33.6	2	1	1.1	0	1.00e+00	Snx16 ENSRNOG00000064438
Indifference point function ln k	13.25	3	0	0	-1	5.13e-08	Prdx5 Vegfb Cdc42bpg
Indifference point function log k	13.25	3	0	0	-1	5.13e-08	Prdx5 Vegfb Cdc42bpg
Delay discounting total patch changes 0 sec	17.74	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Delay discounting total patch changes 12 sec	102.69	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Delay discounting total patch changes 18 sec	175.33	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Delay discounting total patch changes 24 sec	43.71	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Delay discounting total patch changes 6 sec	98.45	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Delay discounting time to switch 0 sec	12.99	23	0	0	-1	2.75e-156	Crip2 Tmem121 NEWGENE_619861 Mark3 Xrcc3 Cdca4 Gpr132 Jag2 Nudt14 Brf1 Btbd6 Pacs2 Pld4 Akt1 Siva1 Inf2 Cep170b Rd3l Lbhd2 Adssl1 ENSRNOG00000065195 ENSRNOG00000067921 Tedc1
Delay discounting water rate 0 sec	17.76	38	33	35.1	0.98	1.79e-146	Crip2 Tmem121 Wdr20 Mok Cinp Traf3 NEWGENE_619861 Mark3 Klc1 Xrcc3 Zfyve21 Ppp1r13b ENSRNOG00000013097 Tmem179 Kif26a Clba1 Cdca4 Gpr132 Jag2 Nudt14 Brf1 Btbd6 Pacs2 Crip1 Tex22 Pld4 Akt1 Siva1 Inf2 Cep170b Rd3l Lbhd2 Adssl1 Tdrd9 ENSRNOG00000064438 ENSRNOG00000065195 ENSRNOG00000067921 Tedc1
Delay discounting water rate 12 sec	14.05	35	1	1.1	-0.58	2.07e-07	Wdr20 Klc1 Zfyve21 Znrd2 Bbs1 Brms1 Yif1a Banf1 Eif1ad Fibp Efemp2 Mus81 Cfl1 Ovol1 Dpf2 Vps51 Snx15 Arl2 Men1 Rps6ka4 Otub1 Slc22a20 Scyl1 Fam89b Snx32 Ctsw Siva1 Slc25a45 Dpp3 Rd3l Adssl1 Rin1 Ehbp1l1 Sptbn2 ENSRNOG00000064438
Delay discounting water rate 24 sec	62.69	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Delay discounting water rate 6 sec	44.17	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Locomotor testing distance	14.01	1	0	0	0	1.00e+00	ENSRNOG00000064438
Locomotor testing rearing	23.89	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Light reinforcement 1	54.81	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Reaction time num false alarms	56.4	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Reaction time num false alarms AUC	79.45	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Reaction time mean	41.28	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Reaction time mean AUC	57.96	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Median of all reaction times	51.19	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Reaction time false alarm rate	63.39	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Reaction time premature initiation rate	32.14	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Reaction time premature initiations	34.33	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Std. dev. reaction times	26.97	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Reaction time trials AUC	15.57	1	0	0	0	1.00e+00	ENSRNOG00000064438
Social responses	74.35	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Cocaine response after cond. corrected	77.95	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Cocaine response after cond. not corrected	102.33	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Cocaine response before conditioning	28.56	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Saline control response	50.64	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Condit. Reinf. active minus inactive responses	46.4	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Condit. Reinf. active-inactive response ratio	68.68	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Condit. Reinf. inactive responses	20.59	1	0	0	0	1.00e+00	ENSRNOG00000064438
Pavlov. Cond. lever latency	60.53	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Pavlov. Cond. magazine entry latency	104.88	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Pavlov. Cond. change in total contacts	130.08	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Pavlov. Cond. index score	62.19	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Pavlov. Cond. latency score	67.08	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Pavlov. Cond. lever contacts	29.45	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Pavlov. Cond. magazine entry number	150.01	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Pavlov. Cond. intertrial magazine entries	63.93	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Pavlov. Cond. lever-magazine prob. diff.	55.11	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Pavlov. Cond. response bias	51.3	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Intermittent access intake day 1-15 change	61.45	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Intermittent access intake escalation	82.51	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Intermittent access intake escalation 2	35.34	2	2	2.1	0	1.00e+00	Snx16 ENSRNOG00000064438
Intermitt. access day 1 inactive lever presses	30.61	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Intermittent access day 1 total infusions	52.87	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Intermittent access day 1 locomotion	27.14	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Intermittent access standard deviation	19.77	1	0	0	0	1.00e+00	Snx16
Post-drug Anxiety	26.41	2	1	1.1	0	1.00e+00	Snx16 ENSRNOG00000064438
Progressive ratio test 2 breakpoint	61.59	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Short access day 10 total infusions	24.04	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Compulsive drug intake	45.38	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
One hour access (shock baseline)	16.79	2	0	0	0	1.00e+00	Sf1 Nrxn2
Context. condit. distance diff. score	149.78	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Locomotion velocity, session 1	117.78	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Locomotion distance, session 1	374.74	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Locomotion velocity, session 2	82.2	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Locomotion distance, session 2	775.97	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Locomotion velocity, session 3	116.11	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Locomotion distance, session 3	82.39	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Stereotopy head waving duration, day 3	25.57	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Locomotion velocity, session 7	66.34	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Locomotion distance, session 7	31.83	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Stereotopy head waving bouts, day 7	42.65	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Stereotopy head waving duration, day 7	63.39	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Locomotion distance, session 8	102.75	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Degree of sensitization distance	140.58	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Degree of sensitization stereotypy	37.55	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Condit. Reinf. active-inactive response ratio	65.09	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Condit. Reinf. active responses	20.03	1	0	0	0	1.00e+00	ENSRNOG00000064438
Condit. Reinf. inactive responses	17.25	1	0	0	0	1.00e+00	ENSRNOG00000064438
Incentive salience index mean	15.58	1	0	0	0	1.00e+00	ENSRNOG00000064438
Condit. Reinf. lever presses	35.11	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Total zone transitions, hab. session 1	415.63	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Total locomotion distance, hab. session 1	171.39	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Locomotion velocity, hab. session 1	218.59	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Time in familiar zone, hab. session 2	48.88	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Time in novel zone, hab. session 2	58.43	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Total zone transitions, hab. session 2	256.06	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Total locomotion distance, hab. session 2	133.05	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Locomotion velocity, hab. session 2	139.44	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Total zone transitions, NPP test	228.75	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Total locomotion distance, NPP test	163.42	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Locomotion velocity, NPP test	195.87	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Pavlov. Cond. magazine entry latency	56.4	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Pavlov. Cond. change in total contacts	40.12	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Pavlov. Cond. index score	51.85	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Pavlov. Cond. latency score	16.59	1	0	0	0	1.00e+00	ENSRNOG00000064438
Pavlov. Cond. lever contacts	16.14	1	0	0	0	1.00e+00	ENSRNOG00000064438
Pavlov. Cond. magazine entry number	22.74	6	1	1.1	-1	3.73e-05	Cdk12 Zpbp2 Thra ENSRNOG00000028430 Stard3 ENSRNOG00000064438
Pavlov. Cond. lever-magazine prob. diff.	88.12	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Pavlov. Cond. response bias	52.36	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Bone: apparent density	21.46	2	1	1.1	0	1.00e+00	Hdac7 ENSRNOG00000064438
Bone surface	16.61	8	3	3.2	-0.56	1.16e-01	Snapc2 Ddx42 Dcaf7 Tmem106c Hdac7 Map3k3 Ace ENSRNOG00000064438
Bone volume	20.05	4	1	1.1	-1	4.86e-05	Ddx42 Map3k3 Ace ENSRNOG00000064438
Bone: connectivity density	12.32	3	0	0	1	5.09e-05	Snapc2 Elavl1 Zfp958
Bone: cortical porosity	64.8	3	1	1.1	0.61	3.92e-01	Ddx42 Dcaf7 ENSRNOG00000064438
Bone: cortical porosity	91.2	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Bone: cortical thickness	17.92	1	0	0	0	1.00e+00	ENSRNOG00000064438
Bone: elastic displacement	28.18	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Bone: endosteal estimation	13.06	4	1	1.1	-0.97	3.26e-02	Ddx42 Dcaf7 Map3k3 ENSRNOG00000064438
Bone: endosteal perimeter	11.94	3	1	1.1	0	1.00e+00	Ddx42 Dcaf7 Map3k3
Bone: final force	30.78	2	1	1.1	0	1.00e+00	Hdac7 ENSRNOG00000064438
Bone: final moment	25.82	2	1	1.1	0	1.00e+00	Hdac7 ENSRNOG00000064438
Bone: marrow area	12.26	4	1	1.1	-0.96	4.23e-02	Ddx42 Dcaf7 Map3k3 ENSRNOG00000064438
Bone: maximum force	14.05	12	2	2.1	0.68	8.93e-07	Dazap2 Asb8 Slc11a2 Pced1b Slc48a1 Tmem106c Rpap3 Hdac7 Pfkm Rapgef3 Atf1 ENSRNOG00000064438
Bone: maximum moment	13.33	12	2	2.1	0.74	1.50e-08	Dazap2 Asb8 Slc11a2 Pced1b Slc48a1 Tmem106c Rpap3 Hdac7 Pfkm Rapgef3 Atf1 ENSRNOG00000064438
Bone: minimum diameter	34.02	3	1	1.1	-1	2.85e-03	Ddx42 Map3k3 ENSRNOG00000064438
Bone: periosteal estimation	12.06	12	2	2.1	0.72	1.68e-07	Ddx42 Asb8 Pced1b Dcaf7 Slc48a1 Tmem106c Rpap3 Hdac7 Pfkm Rapgef3 Map3k3 ENSRNOG00000064438
Bone: periosteal perimeter	11.48	9	0	0	0.92	2.12e-12	Ddx42 Asb8 Pced1b Slc48a1 Tmem106c Rpap3 Hdac7 Pfkm Rapgef3
Bone: post-yield work	82.77	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Bone: stiffness	18.37	14	4	4.3	0.65	5.74e-07	Dazap2 Asb8 Slc11a2 Pced1b Slc48a1 Tmem106c Rpap3 Hdac7 Dip2b Pfkm Rapgef3 Atf1 ENSRNOG00000064438 ENSRNOG00000070769
Bone: tissue strength	80.98	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Bone: trabecular number	39.36	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Bone: trabecular tissue density	28.3	3	1	1.1	1	6.82e-04	Rsl24d1 Tex9 ENSRNOG00000064438
Delta time in open arm before/after self-admin	40.25	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Time in closed arm before self-admin	50.04	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Time in closed arm after self-admin	40.16	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Time in open arm after self-admin	31.26	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Time to tail flick, test, before self-admin	20.61	1	0	0	0	1.00e+00	Snx16
Time >=10cm from walls, locomotor time 1	19.54	1	0	0	0	1.00e+00	ENSRNOG00000064438
Time >=10cm from walls, locomotor time 2	27.2	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Weight adjusted by age	37.65	2	2	2.1	0	1.00e+00	Snx16 ENSRNOG00000064438
Seeking ratio, delayed vs. immediate footshock	22.65	1	1	1.1	0	1.00e+00	Snx16
Food seeking constrained by brief footshock	16.73	1	0	0	0	1.00e+00	Snx16
Run reversals in cocaine runway, males	39.32	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Latency to leave start box in cocaine runway	18.78	1	0	0	0	1.00e+00	ENSRNOG00000064438
Cd content in liver	140.46	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Co content in liver	83.15	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
K content in liver	62.65	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Mn content in liver	130.23	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Rb content in liver	31.44	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Se content in liver	46.95	1	1	1.1	0	1.00e+00	ENSRNOG00000064438
Zn content in liver	45.96	1	1	1.1	0	1.00e+00	ENSRNOG00000064438

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	45	2.1	4.04
Adipose	alternative TSS	36	2.2	4.43
Adipose	gene expression	154	1.9	4.05
Adipose	isoform ratio	55	1.9	3.94
Adipose	intron excision ratio	34	1.2	3.43
Adipose	mRNA stability	62	1.8	3.83
BLA	alternative polyA	24	2	4.33
BLA	alternative TSS	16	1.9	3.99
BLA	gene expression	121	2	4.11
BLA	isoform ratio	34	1.9	4.39
BLA	intron excision ratio	52	1.7	3.88
BLA	mRNA stability	37	1.8	4.05
Brain	alternative polyA	51	2.5	4.46
Brain	alternative TSS	37	2.2	4.22
Brain	gene expression	170	1.9	4.04
Brain	isoform ratio	47	1.5	4.22
Brain	intron excision ratio	108	2	4.04
Brain	mRNA stability	86	2	3.94
Eye	alternative polyA	3	1.7	3.81
Eye	alternative TSS	3	1.2	4.13
Eye	gene expression	21	1.9	3.89
Eye	isoform ratio	6	1.7	4.41
Eye	intron excision ratio	12	2	4.01
Eye	mRNA stability	5	2.1	4.17
IL	alternative polyA	21	3.4	4.84
IL	alternative TSS	5	1.7	3.77
IL	gene expression	66	1.8	3.82
IL	isoform ratio	12	1.5	3.74
IL	intron excision ratio	18	1.9	3.78
IL	mRNA stability	25	2.3	4.17
LHb	alternative polyA	10	1.7	3.86
LHb	alternative TSS	13	3.7	4.23
LHb	gene expression	58	1.8	3.8
LHb	isoform ratio	13	1.7	3.75
LHb	intron excision ratio	11	1.1	3.29
LHb	mRNA stability	16	1.5	4
Liver	alternative polyA	30	2	4.07
Liver	alternative TSS	19	1.3	3.84
Liver	gene expression	135	1.9	3.88
Liver	isoform ratio	31	1.3	3.63
Liver	intron excision ratio	93	2.1	3.84
Liver	mRNA stability	61	2.5	3.98
NAcc	alternative polyA	40	3.1	4.57
NAcc	alternative TSS	15	1.6	3.99
NAcc	gene expression	117	1.9	3.96
NAcc	isoform ratio	37	2	4.38
NAcc	intron excision ratio	63	2.1	4.03
NAcc	mRNA stability	47	2.1	4.06
OFC	alternative polyA	12	2.1	4.15
OFC	alternative TSS	7	2.2	4.02
OFC	gene expression	77	2.1	4.01
OFC	isoform ratio	16	2	4.08
OFC	intron excision ratio	31	3.1	4.35
OFC	mRNA stability	26	2.4	4.22
PL	alternative polyA	45	3.2	4.78
PL	alternative TSS	47	4	4.83
PL	gene expression	157	2.1	4.09
PL	isoform ratio	54	2.4	4.43
PL	intron excision ratio	73	2	3.89
PL	mRNA stability	65	2.2	4.03