Hub : Traits

Extensor digitorum longus weight

Weight in grams of the extensor digitorum longus (EDL). Located in the anterior compartment of the leg, it extends the lateral four toes and also contributes to ankle dorsiflexion.

Tags: Physiology · Muscle

Project: lionikas_2014

2785 significantly associated models · 563 unique genes

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 171727837 174685359 3 1 1.7e-07 9.4e-07 2.5e-65 -1111 Rps15a
2 1 176946412 178345186 1 1 3.1e-08 3.7e-07 1.4e-02 77 Tnrc6a
3 1 199398809 208295455 132 8 3.5e-10 1.2e-09 1.0e+00 100 Tpcn2 Ganab Sf3b2 Cfl1 Ppp2r5b Tmem134 Ctsw Atg2a
4 2 86361148 88973805 2 1 3.2e-10 1.6e-10 1.0e+00 100 Ralyl
5 2 89673058 95023945 16 1 1.8e-13 1.0e-13 1.0e+00 100 Zfp704
6 2 97341393 99049575 2 1 8.4e-08 2.5e-08 1.0e+00 100 Hnf4g
7 2 99787494 102500927 6 1 1.9e-08 1.1e-08 1.2e-01 92 Cyp7b1
8 2 225972996 228461478 7 1 8.3e-10 1.2e-12 1.1e-04 70 Rap1gds1
9 4 146441482 149011707 7 1 1.5e-09 1.2e-09 1.4e-01 94 Slc6a11
10 5 54563228 57839987 7 2 8.2e-08 2.1e-08 8.8e-02 91 Ddx58 Aptx
11 6 129055047 132888501 37 4 3.4e-12 5.1e-11 1.0e+00 100 Siva1 Inf2 Cep170b Tedc1
12 7 29535 2057232 31 4 1.5e-07 1.5e-07 1.0e+00 100 Ikzf4 Rab5b Dnajc14 Sarnp
13 7 16845355 16970279 1 1 4.6e-36 NaN NA NA NA
14 7 83305298 85971312 3 2 6.8e-08 5.9e-08 0.0e+00 -8766 Med30 NA
15 7 87430397 88835787 2 1 4.2e-08 7.7e-10 1.0e+00 100 Has2
16 7 127692699 129997098 8 2 7.5e-08 1.1e-07 1.0e+00 100 Slc48a1 Rapgef3
17 7 130474807 134497678 35 6 6.0e-11 9.7e-09 1.0e+00 100 Dazap2 Scn8a Csad Krt80 Galnt6 Krt71
18 8 69336832 75537324 30 6 2.7e-09 1.7e-09 1.0e+00 100 Rsl24d1 Ccpg1 Unc13c Myzap Nedd4 Pigb
19 9 41500976 42900083 1 1 3.4e-07 2.6e-07 1.0e+00 100 Map4k4
20 9 44247541 50043612 31 10 9.3e-12 8.1e-12 1.0e+00 100 Wdr75 Osgepl1 Tpp2 Nemp2 Mrps9 RGD1310553 Fhl2 Nck2 Ercc5 Ormdl1
21 10 58773413 61500745 15 1 2.7e-08 2.3e-08 1.0e+00 100 Crk
22 10 81422075 86251828 46 8 1.0e-11 1.5e-10 NaN NaN Krt15 Rpl19 Thra Rara Igfbp4 Srcin1 Ormdl3 Stard3
23 10 87148755 89011911 6 3 8.9e-08 1.7e-07 1.0e+00 100 Gfap Acbd4 Arhgap27
24 10 90210853 92351292 6 1 4.4e-09 3.4e-07 3.9e-01 97 Map3k3
25 12 27006 4653252 12 6 1.0e-08 7.1e-08 1.0e+00 100 Trappc5 Cers4 N4bp2l2 Insr Pet100 Zfp958
26 14 8196668 10268633 7 1 7.4e-08 1.9e-07 4.7e-01 98 Lin54
27 14 16470695 22686240 33 5 1.6e-16 1.6e-15 NaN NaN Alb Gc Slc4a4 Rufy3 Adamts3
28 15 35796833 43041493 41 7 3.8e-13 3.2e-13 1.0e+00 100 Dleu7 Gucy1b2 NA Msra Gulo Chrna2 Ptk2b
29 15 43349498 46640839 28 6 2.3e-13 5.5e-13 1.0e+00 100 Sorbs3 Phyhip Lgi3 Nudt18 R3hcc1 Egr3
30 15 47167781 49440043 7 1 2.1e-11 7.8e-13 4.1e-03 84 Fndc3a

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
BMI with tail 7.1 88 21 22.3 1.00 7.6e-244 Naca Ptges3 Atp5f1b Rbms2 Cnpy2 Dazap2 Med30 Pa2g4 Erbb3 Ikzf4 Suox Rab5b Tmem198b Dnajc14 Cd63 Bloc1s1 Itga7 Ice2 Znrd2 Nab1 Banf1 Eif1ad Ovol1 Dpf2 Snx15 Arl2 Nrxn2 Slc22a12 Rps6ka4 Kcnk4 Gpr137 Bad Macrod1 Otub1 Rtn3 Atl3 Flrt1 Dgka Rnf41 Scyl1 Fam89b Ext1 Snx32 Hibch AC128207.1 Coq10a Ormdl2 Sarnp Slc25a45 Stat2 Smarcc2 Dpp3 Gls2 Timeless Prim1 Galnt6 Zc3h10 NA Rab27a Rsl24d1 Ccpg1 Baz2a Myl6 Adam10 Khdc3 AC142458.1 Wdr72 Prtg Hdac7 Bnip2 Ehbp1l1 Gls Unc13c Dnaaf4 Fam81a Myzap Nedd4 Pigb Tex9 Rnf111 Esyt1 Atf1 Aqp9 Myo1e NA NA NA Pygo1
BMI without tail 17.2 9 2 2.1 0.46 1.3e-02 Snx16 Tpd52 Mrps28 RGD1559600 NA Zfp704 Zbtb10 Hey1 NA
Body weight 6.0 148 47 50.0 0.97 0.0e+00 Stxbp2 Trappc5 Snapc2 Timm44 Elavl1 Cers4 N4bp2l2 Cwc25 Lasp1 Cacnb1 Dazap2 Rpl19 Stac2 Med30 Fbxl20 Med1 Cdk12 Erbb2 Ikzf3 Zpbp2 Thra Nr1d1 Tbx21 Msl1 Casc3 Snx16 Rara Asb8 Ice2 Igfbp4 Srcin1 Krt12 Pcgf2 Znrd2 Metap1 Pip4k2b Tspan5 Rap1gds1 Kmt5b Slc22a8 Taf6l Ttc9c Slc11a2 Bbs1 B3gat3 Peli3 Slc29a2 Eef1g Brms1 Yif1a Rab3il1 Fads3 Sf3b2 Banf1 Eif1ad Sart1 Fibp Efemp2 Mus81 Cfl1 Ovol1 Frmd8 Dpf2 Pola2 Tm7sf2 Vps51 Snx15 Arl2 Ppp2r5b Nrxn2 Slc22a12 Rps6ka4 Prdx5 Kcnk4 Gpr137 Bad Vegfb Fermt3 Macrod1 Otub1 Rtn3 Atl3 Flrt1 Slc22a20 Arhgap23 Pced1b Scyl1 Fam89b Ext1 Snx32 Ctsw Cdc42bpg Tsga10ip Rapgefl1 Arhgef18 Ppp1r1b NA Insr Ormdl3 Slc25a45 Dpp3 Galnt6 Krt26 Arl5c Fbxo47 Cisd3 Stard3 NA Ehd1 Epop NA Pet100 Gjd3 Eif4e Slc48a1 Tmem106c Mllt6 Rpap3 Ccpg1 Adam10 Majin Aldh1a2 Hdac7 Bnip2 Ehbp1l1 Dip2b Fam81a Ahnak Myzap Pfkm Nedd4 Socs7 N4bp2l1 Gcnt3 Pigb Rapgef3 Rnf111 Atf1 Mindy2 Aqp9 Myo1e NA Zfp958 Pygo1 Tcap Lrrc3c NA NA
Epididymis fat weight 87.6 1 1 1.1 0.00 1.0e+00 NA
Left kidney weight 13.0 14 11 11.7 0.61 2.6e-04 Stxbp2 Trappc5 Snapc2 Timm44 Elavl1 Cers4 N4bp2l2 Tnrc6a Arhgef18 Insr Pet100 N4bp2l1 NA Zfp958
Right kidney weight 11.4 14 9 9.6 0.55 1.8e-03 Stxbp2 Trappc5 Snapc2 Timm44 Elavl1 Cers4 N4bp2l2 Tnrc6a Arhgef18 Insr Pet100 N4bp2l1 NA Zfp958
Tail length 12.0 19 13 13.8 0.56 4.1e-04 Stxbp2 Trappc5 Snapc2 Timm44 Elavl1 Cers4 N4bp2l2 Snx16 Cdca4 Brf1 Arhgef18 Insr Cep170b Pet100 N4bp2l1 NA NA Zfp958 Tedc1
Length with tail 9.5 63 38 40.4 0.92 3.1e-119 Stxbp2 Trappc5 Snapc2 Timm44 Elavl1 Cers4 N4bp2l2 Alb Gc Cwc25 Lasp1 Cacnb1 Rpl19 Crip2 Tmem121 Cdk12 Tbx21 Srcin1 Klc1 Xrcc3 Zfyve21 Ppp1r13b Pcgf2 Pip4k2b NA Tmem179 Kif26a Clba1 Cdca4 Gpr132 Jag2 Nudt14 Brf1 Btbd6 Pacs2 Arhgap23 Adamts3 Crip1 Arhgef18 Tex22 NA Pld4 Akt1 Siva1 Inf2 Insr Cep170b Cisd3 NA Stard3 Rd3l Adssl1 Epop Pet100 Mllt6 Tdrd9 N4bp2l1 NA Zfp958 NA Tcap Tedc1 NA
Length without tail 13.6 19 11 11.7 0.99 7.5e-42 Stxbp2 Trappc5 Snapc2 Timm44 Elavl1 Cers4 N4bp2l2 Asb8 Arhgef18 Pet100 Slc48a1 Tmem106c Rpap3 Hdac7 Pfkm N4bp2l1 Rapgef3 NA Zfp958
Liver weight, left 23.6 1 1 1.1 0.00 1.0e+00 NA
Parametrial fat weight 26.4 1 1 1.1 0.00 1.0e+00 NA
Retroperitoneal fat weight 6.2 83 0 0.0 -1.00 0.0e+00 Znrd2 Tpcn2 Ighmbp2 Cpt1a Ppp6r3 Lrp5 Kmt5b Tcirg1 Ndufs8 Aldh3b1 Gstp1 Actn3 Bbs1 Peli3 Slc29a2 Brms1 Yif1a Cnih2 Klc2 Pacs1 Sf3b2 Cst6 Banf1 Eif1ad Sart1 Drap1 Efemp2 Mus81 Cfl1 NA Ltbp3 Frmd8 Dpf2 Ccnd1 Fau Tm7sf2 Vps51 Sac3d1 Snx15 Arl2 NA Ppp2r5b Men1 Map4k2 Sf1 Nrxn2 Rps6ka4 Prdx5 Esrra Kcnk4 Gpr137 Bad Plcb3 Macrod1 Otub1 Naa40 Atl3 Tmem134 Aip Fam89b Ccdc88b Ctsw Cdc42bpg Tsga10ip Gal3st3 Slc25a45 Dpp3 Ehd1 Rbm14 Cdca5 Ccs NEWGENE_1310680 Zfpl1 Rin1 NA Majin AC126581.1 Sptbn2 Atg2a Rbm4b NA Aldh3b2 Rab1b
Intraocular pressure 29.4 1 1 1.1 0.00 1.0e+00 NA
Soleus weight 12.8 71 31 33.0 0.87 2.8e-69 Enoph1 Ptges3 Atp5f1b Alb Rbms2 Cnpy2 Pa2g4 Erbb3 Ikzf4 Suox Rab5b Tmem198b Dnajc14 Cd63 Bloc1s1 Itga7 Ice2 Bbs1 Slc29a2 Brms1 Cnih2 Dgka Rnf41 Adamts3 AC128207.1 Coq10a Ormdl2 Sarnp Stat2 Smarcc2 Gls2 Timeless Prim1 Zc3h10 Ccs Rab27a Rsl24d1 Ccpg1 Baz2a Myl6 Adam10 Khdc3 AC142458.1 Wdr72 Aldh1a2 Prtg Bnip2 Mir628 Unc13c Dnaaf4 Fam81a Myzap Tcf12 Sptbn2 Nedd4 Gcnt3 Pigb Tex9 Rfx7 Rnf111 Esyt1 Mindy2 Rbm4b Aqp9 Myo1e NA NA NA NA Pygo1 NA
Tibialis anterior weight 10.0 342 306 325.5 0.98 0.0e+00 Phf24 Stxbp2 Trappc5 Snapc2 Timm44 Elavl1 Cers4 N4bp2l2 Mettl7a Rap1gap2 Gc Rtn4rl1 Rpa1 Slc4a4 Serpinf1 Dck Rufy3 Slc43a2 Myo1c Dazap2 Scn8a Aco1 Ddx58 Aptx Smu1 Atg101 NA Krt86 Pdlim2 Sorbs3 Hnf4g Dleu7 Rnaseh2b Gucy1b2 Trim35 NA Dpysl2 Cyp7b1 Ppp3cc Fam124a Pnma2 Bnip3l Slc39a14 Piwil2 Ints6 Snx16 Polr3d Wdfy2 Ythdf3 Ice2 Phyhip Fabp4 Bmp1 Igfbp6 Mob1b Trmt10a Ppp2r2a Lgi3 Ralyl Hr Tpd52 Csad Nudt18 Pinx1 Fhip2b Sox7 Dmtn Msra Rarg Znrd2 Fgf17 Metap1 Kctd9 Pde7a Kif13b Nudt2 Armc1 Hmbox1 Tpcn2 Ighmbp2 Ints9 Extl3 Nefl Nefm Dok2 Fbxo16 Gfra2 Pnoc Cpt1a Elp3 Scara5 Fndc3a Map3k12 Atp5mc2 Slc25a37 Ppp6r3 Lrp5 Tspan5 Esco2 Ccdc25 Rap1gds1 Scara3 Entpd4 Clu Gulo Loxl2 R3hcc1 Kmt5b Chmp7 Tcirg1 Ephx2 Rhobtb2 Chrna2 Ndufs8 Aldh3b1 Unc93b1 Egr3 Bin3 Doc2g Slc22a8 Slc22a6 Gstp1 Ccar2 Rps15a Slc3a2 Pitpnm1 Stx5 Nxf1 Tmem223 Pc Taf6l Ttc9c Slc11a2 Ubxn1 RGD1597339 Ctsf Ganab Actn3 Bbs1 Rom1 B3gat3 Mta2 Peli3 Slc29a2 Tut1 Eef1g Brms1 Yif1a Asrgl1 Cnih2 Klc2 Rab3il1 Pacs1 Fads3 Sf3b2 Cst6 Banf1 Eif1ad Sart1 Drap1 Fibp Efemp2 Mus81 Ppp1r32 Sdhaf2 Cfl1 Cpsf7 Ovol1 Tmem216 NA Ltbp3 Frmd8 Dpf2 Pola2 Ccnd1 Ccdc86 Fau Tm7sf2 Vps51 Sac3d1 Snx15 Arl2 NA Ppp2r5b Men1 Map4k2 Sf1 Nrxn2 Slc22a12 Rps6ka4 Prdx5 Esrra Kcnk4 Gpr137 Bad Plcb3 Vegfb Fermt3 Macrod1 Otub1 Naa40 Rtn3 Atl3 Plaat3 Mtfr1 Bhlhe22 Tmem134 Aip Zc2hc1a Flrt1 tGap1 Fth1 Slc22a20 Pmp2 Stpg2 Scyl1 Fam89b Dock5 Tnrc6a Ext1 Ccdc88b Crk Krt80 Ints5 Syt7 Snx32 Smyd4 Ctsw Sgsm2 Cdc42bpg Adamts3 Tsga10ip Ptk2b Arhgef18 Gal3st3 Slc4a8 Krt1 Insr Slc25a45 Dpp3 Krt4 Tfcp2 Mrps28 Adh7 Galnt6 Pcbp2 Krt77 Tnfrsf10b Fabp12 Prr13 RGD1559600 NA Ehd1 Uqcc3 Rbm14 Cdca5 Fzd3 Prss55 NA Ccs NA NA Krt71 NEWGENE_1310680 Pet100 Zfpl1 Rin1 Gde1 NA Eif4e Rab27a Rsl24d1 Stmn4 Ccpg1 Soat2 Adam10 Majin Zfp704 Khdc3 AC142458.1 Wdr72 Aldh1a2 Prtg Bnip2 Ehbp1l1 Dip2b Mir628 Unc13c Dnaaf4 Inpp5k Fam81a Ahnak Myzap Tcf12 AC126581.1 Sptbn2 Nedd4 N4bp2l1 Gcnt3 Scarf1 Pigb Tex9 Doc2b Rfx7 Atg2a Rnf111 Atf1 Pag1 Mindy2 Rph3al Rbm4b Zbtb10 Aqp9 Myo1e NA NA Hey1 NA NA NA Zfp958 NA NA Pygo1 NA NA NA NA Slc10a5 NA Aldh3b2 NA Krt6a NA NA Smim27 NA NA Krt6a NA NA Rab1b
Tibia length 7.3 3 0 0.0 0.22 6.8e-01 Fndc3a Pet100 NA
Number of licking bursts 155.0 1 1 1.1 0.00 1.0e+00 NA
Food consumed during 24 hour testing period 17.5 1 0 0.0 0.00 1.0e+00 NA
Times rat made contact with spout 75.1 1 1 1.1 0.00 1.0e+00 NA
Mean time between licks in bursts 54.9 1 1 1.1 0.00 1.0e+00 NA
Mean num. licks in bursts 164.2 1 1 1.1 0.00 1.0e+00 NA
Std. dev. time between licks in bursts 177.7 1 1 1.1 0.00 1.0e+00 NA
Indifference point 0 sec 16.4 2 1 1.1 0.00 1.0e+00 Bnip3l NA
Indifference point AUC 33.6 2 1 1.1 0.00 1.0e+00 Snx16 NA
Indifference point function ln k 13.2 3 0 0.0 -1.00 5.1e-08 Prdx5 Vegfb Cdc42bpg
Indifference point function log k 13.2 3 0 0.0 -1.00 5.1e-08 Prdx5 Vegfb Cdc42bpg
Delay discounting total patch changes 0 sec 17.7 1 1 1.1 0.00 1.0e+00 NA
Delay discounting total patch changes 12 sec 102.7 1 1 1.1 0.00 1.0e+00 NA
Delay discounting total patch changes 18 sec 175.3 1 1 1.1 0.00 1.0e+00 NA
Delay discounting total patch changes 24 sec 43.7 1 1 1.1 0.00 1.0e+00 NA
Delay discounting total patch changes 6 sec 98.5 1 1 1.1 0.00 1.0e+00 NA
Delay discounting time to switch 0 sec 13.0 23 0 0.0 -1.00 2.7e-156 Crip2 Tmem121 NEWGENE_619861 Mark3 Xrcc3 Cdca4 Gpr132 Jag2 Nudt14 Brf1 Btbd6 Pacs2 Pld4 Akt1 Siva1 Inf2 Cep170b Rd3l Lbhd2 Adssl1 NA NA Tedc1
Delay discounting water rate 0 sec 17.8 38 33 35.1 0.98 1.8e-146 Crip2 Tmem121 Wdr20 Mok Cinp Traf3 NEWGENE_619861 Mark3 Klc1 Xrcc3 Zfyve21 Ppp1r13b NA Tmem179 Kif26a Clba1 Cdca4 Gpr132 Jag2 Nudt14 Brf1 Btbd6 Pacs2 Crip1 Tex22 Pld4 Akt1 Siva1 Inf2 Cep170b Rd3l Lbhd2 Adssl1 Tdrd9 NA NA NA Tedc1
Delay discounting water rate 12 sec 14.1 35 1 1.1 -0.58 2.1e-07 Wdr20 Klc1 Zfyve21 Znrd2 Bbs1 Brms1 Yif1a Banf1 Eif1ad Fibp Efemp2 Mus81 Cfl1 Ovol1 Dpf2 Vps51 Snx15 Arl2 Men1 Rps6ka4 Otub1 Slc22a20 Scyl1 Fam89b Snx32 Ctsw Siva1 Slc25a45 Dpp3 Rd3l Adssl1 Rin1 Ehbp1l1 Sptbn2 NA
Delay discounting water rate 24 sec 62.7 1 1 1.1 0.00 1.0e+00 NA
Delay discounting water rate 6 sec 44.2 1 1 1.1 0.00 1.0e+00 NA
Locomotor testing distance 14.0 1 0 0.0 0.00 1.0e+00 NA
Locomotor testing rearing 23.9 1 1 1.1 0.00 1.0e+00 NA
Light reinforcement 1 54.8 1 1 1.1 0.00 1.0e+00 NA
Reaction time num false alarms 56.4 1 1 1.1 0.00 1.0e+00 NA
Reaction time num false alarms AUC 79.5 1 1 1.1 0.00 1.0e+00 NA
Reaction time mean 41.3 1 1 1.1 0.00 1.0e+00 NA
Reaction time mean AUC 58.0 1 1 1.1 0.00 1.0e+00 NA
Median of all reaction times 51.2 1 1 1.1 0.00 1.0e+00 NA
Reaction time false alarm rate 63.4 1 1 1.1 0.00 1.0e+00 NA
Reaction time premature initiation rate 32.1 1 1 1.1 0.00 1.0e+00 NA
Reaction time premature initiations 34.3 1 1 1.1 0.00 1.0e+00 NA
Std. dev. reaction times 27.0 1 1 1.1 0.00 1.0e+00 NA
Reaction time trials AUC 15.6 1 0 0.0 0.00 1.0e+00 NA
Social responses 74.3 1 1 1.1 0.00 1.0e+00 NA
Cocaine response after cond. corrected 78.0 1 1 1.1 0.00 1.0e+00 NA
Cocaine response after cond. not corrected 102.3 1 1 1.1 0.00 1.0e+00 NA
Cocaine response before conditioning 28.6 1 1 1.1 0.00 1.0e+00 NA
Saline control response 50.6 1 1 1.1 0.00 1.0e+00 NA
Condit. Reinf. active minus inactive responses 46.4 1 1 1.1 0.00 1.0e+00 NA
Condit. Reinf. active-inactive response ratio 68.7 1 1 1.1 0.00 1.0e+00 NA
Condit. Reinf. inactive responses 20.6 1 0 0.0 0.00 1.0e+00 NA
Pavlov. Cond. lever latency 60.5 1 1 1.1 0.00 1.0e+00 NA
Pavlov. Cond. magazine entry latency 104.9 1 1 1.1 0.00 1.0e+00 NA
Pavlov. Cond. change in total contacts 130.1 1 1 1.1 0.00 1.0e+00 NA
Pavlov. Cond. index score 62.2 1 1 1.1 0.00 1.0e+00 NA
Pavlov. Cond. latency score 67.1 1 1 1.1 0.00 1.0e+00 NA
Pavlov. Cond. lever contacts 29.4 1 1 1.1 0.00 1.0e+00 NA
Pavlov. Cond. magazine entry number 150.0 1 1 1.1 0.00 1.0e+00 NA
Pavlov. Cond. intertrial magazine entries 63.9 1 1 1.1 0.00 1.0e+00 NA
Pavlov. Cond. lever-magazine prob. diff. 55.1 1 1 1.1 0.00 1.0e+00 NA
Pavlov. Cond. response bias 51.3 1 1 1.1 0.00 1.0e+00 NA
Intermittent access intake day 1-15 change 61.5 1 1 1.1 0.00 1.0e+00 NA
Intermittent access intake escalation 82.5 1 1 1.1 0.00 1.0e+00 NA
Intermittent access intake escalation 2 35.3 2 2 2.1 0.00 1.0e+00 Snx16 NA
Intermitt. access day 1 inactive lever presses 30.6 1 1 1.1 0.00 1.0e+00 NA
Intermittent access day 1 total infusions 52.9 1 1 1.1 0.00 1.0e+00 NA
Intermittent access day 1 locomotion 27.1 1 1 1.1 0.00 1.0e+00 NA
Intermittent access standard deviation 19.8 1 0 0.0 0.00 1.0e+00 Snx16
Post-drug Anxiety 26.4 2 1 1.1 0.00 1.0e+00 Snx16 NA
Progressive ratio test 2 breakpoint 61.6 1 1 1.1 0.00 1.0e+00 NA
Short access day 10 total infusions 24.0 1 1 1.1 0.00 1.0e+00 NA
Compulsive drug intake 45.4 1 1 1.1 0.00 1.0e+00 NA
One hour access (shock baseline) 16.8 2 0 0.0 0.00 1.0e+00 Sf1 Nrxn2
Context. condit. distance diff. score 149.8 1 1 1.1 0.00 1.0e+00 NA
Locomotion velocity, session 1 117.8 1 1 1.1 0.00 1.0e+00 NA
Locomotion distance, session 1 374.7 1 1 1.1 0.00 1.0e+00 NA
Locomotion velocity, session 2 82.2 1 1 1.1 0.00 1.0e+00 NA
Locomotion distance, session 2 776.0 1 1 1.1 0.00 1.0e+00 NA
Locomotion velocity, session 3 116.1 1 1 1.1 0.00 1.0e+00 NA
Locomotion distance, session 3 82.4 1 1 1.1 0.00 1.0e+00 NA
Stereotopy head waving duration, day 3 25.6 1 1 1.1 0.00 1.0e+00 NA
Locomotion velocity, session 7 66.3 1 1 1.1 0.00 1.0e+00 NA
Locomotion distance, session 7 31.8 1 1 1.1 0.00 1.0e+00 NA
Stereotopy head waving bouts, day 7 42.6 1 1 1.1 0.00 1.0e+00 NA
Stereotopy head waving duration, day 7 63.4 1 1 1.1 0.00 1.0e+00 NA
Locomotion distance, session 8 102.8 1 1 1.1 0.00 1.0e+00 NA
Degree of sensitization distance 140.6 1 1 1.1 0.00 1.0e+00 NA
Degree of sensitization stereotypy 37.5 1 1 1.1 0.00 1.0e+00 NA
Condit. Reinf. active-inactive response ratio 65.1 1 1 1.1 0.00 1.0e+00 NA
Condit. Reinf. active responses 20.0 1 0 0.0 0.00 1.0e+00 NA
Condit. Reinf. inactive responses 17.2 1 0 0.0 0.00 1.0e+00 NA
Incentive salience index mean 15.6 1 0 0.0 0.00 1.0e+00 NA
Condit. Reinf. lever presses 35.1 1 1 1.1 0.00 1.0e+00 NA
Total zone transitions, hab. session 1 415.6 1 1 1.1 0.00 1.0e+00 NA
Total locomotion distance, hab. session 1 171.4 1 1 1.1 0.00 1.0e+00 NA
Locomotion velocity, hab. session 1 218.6 1 1 1.1 0.00 1.0e+00 NA
Time in familiar zone, hab. session 2 48.9 1 1 1.1 0.00 1.0e+00 NA
Time in novel zone, hab. session 2 58.4 1 1 1.1 0.00 1.0e+00 NA
Total zone transitions, hab. session 2 256.1 1 1 1.1 0.00 1.0e+00 NA
Total locomotion distance, hab. session 2 133.1 1 1 1.1 0.00 1.0e+00 NA
Locomotion velocity, hab. session 2 139.4 1 1 1.1 0.00 1.0e+00 NA
Total zone transitions, NPP test 228.8 1 1 1.1 0.00 1.0e+00 NA
Total locomotion distance, NPP test 163.4 1 1 1.1 0.00 1.0e+00 NA
Locomotion velocity, NPP test 195.9 1 1 1.1 0.00 1.0e+00 NA
Pavlov. Cond. magazine entry latency 56.4 1 1 1.1 0.00 1.0e+00 NA
Pavlov. Cond. change in total contacts 40.1 1 1 1.1 0.00 1.0e+00 NA
Pavlov. Cond. index score 51.9 1 1 1.1 0.00 1.0e+00 NA
Pavlov. Cond. latency score 16.6 1 0 0.0 0.00 1.0e+00 NA
Pavlov. Cond. lever contacts 16.1 1 0 0.0 0.00 1.0e+00 NA
Pavlov. Cond. magazine entry number 22.7 6 1 1.1 -1.00 3.7e-05 Cdk12 Zpbp2 Thra NA Stard3 NA
Pavlov. Cond. lever-magazine prob. diff. 88.1 1 1 1.1 0.00 1.0e+00 NA
Pavlov. Cond. response bias 52.4 1 1 1.1 0.00 1.0e+00 NA
Bone: apparent density 21.5 2 1 1.1 0.00 1.0e+00 Hdac7 NA
Bone surface 16.6 8 3 3.2 -0.56 1.2e-01 Snapc2 Ddx42 Dcaf7 Tmem106c Hdac7 Map3k3 Ace NA
Bone volume 20.1 4 1 1.1 -1.00 4.9e-05 Ddx42 Map3k3 Ace NA
Bone: connectivity density 12.3 3 0 0.0 1.00 5.1e-05 Snapc2 Elavl1 Zfp958
Bone: cortical porosity 64.8 3 1 1.1 0.61 3.9e-01 Ddx42 Dcaf7 NA
Bone: cortical porosity 91.2 1 1 1.1 0.00 1.0e+00 NA
Bone: cortical thickness 17.9 1 0 0.0 0.00 1.0e+00 NA
Bone: elastic displacement 28.2 1 1 1.1 0.00 1.0e+00 NA
Bone: endosteal estimation 13.1 4 1 1.1 -0.97 3.3e-02 Ddx42 Dcaf7 Map3k3 NA
Bone: endosteal perimeter 11.9 3 1 1.1 0.00 1.0e+00 Ddx42 Dcaf7 Map3k3
Bone: final force 30.8 2 1 1.1 0.00 1.0e+00 Hdac7 NA
Bone: final moment 25.8 2 1 1.1 0.00 1.0e+00 Hdac7 NA
Bone: marrow area 12.3 4 1 1.1 -0.96 4.2e-02 Ddx42 Dcaf7 Map3k3 NA
Bone: maximum force 14.1 12 2 2.1 0.68 8.9e-07 Dazap2 Asb8 Slc11a2 Pced1b Slc48a1 Tmem106c Rpap3 Hdac7 Pfkm Rapgef3 Atf1 NA
Bone: maximum moment 13.3 12 2 2.1 0.74 1.5e-08 Dazap2 Asb8 Slc11a2 Pced1b Slc48a1 Tmem106c Rpap3 Hdac7 Pfkm Rapgef3 Atf1 NA
Bone: minimum diameter 34.0 3 1 1.1 -1.00 2.9e-03 Ddx42 Map3k3 NA
Bone: periosteal estimation 12.1 12 2 2.1 0.72 1.7e-07 Ddx42 Asb8 Pced1b Dcaf7 Slc48a1 Tmem106c Rpap3 Hdac7 Pfkm Rapgef3 Map3k3 NA
Bone: periosteal perimeter 11.5 9 0 0.0 0.92 2.1e-12 Ddx42 Asb8 Pced1b Slc48a1 Tmem106c Rpap3 Hdac7 Pfkm Rapgef3
Bone: post-yield work 82.8 1 1 1.1 0.00 1.0e+00 NA
Bone: stiffness 18.4 14 4 4.3 0.65 5.7e-07 Dazap2 Asb8 Slc11a2 Pced1b Slc48a1 Tmem106c Rpap3 Hdac7 Dip2b Pfkm Rapgef3 Atf1 NA NA
Bone: tissue strength 81.0 1 1 1.1 0.00 1.0e+00 NA
Bone: trabecular number 39.4 1 1 1.1 0.00 1.0e+00 NA
Bone: trabecular tissue density 28.3 3 1 1.1 1.00 6.8e-04 Rsl24d1 Tex9 NA
Delta time in open arm before/after self-admin 40.2 1 1 1.1 0.00 1.0e+00 NA
Time in closed arm before self-admin 50.0 1 1 1.1 0.00 1.0e+00 NA
Time in closed arm after self-admin 40.2 1 1 1.1 0.00 1.0e+00 NA
Time in open arm after self-admin 31.3 1 1 1.1 0.00 1.0e+00 NA
Time to tail flick, test, before self-admin 20.6 1 0 0.0 0.00 1.0e+00 Snx16
Time >=10cm from walls, locomotor time 1 19.5 1 0 0.0 0.00 1.0e+00 NA
Time >=10cm from walls, locomotor time 2 27.2 1 1 1.1 0.00 1.0e+00 NA
Weight adjusted by age 37.6 2 2 2.1 0.00 1.0e+00 Snx16 NA
Seeking ratio, delayed vs. immediate footshock 22.6 1 1 1.1 0.00 1.0e+00 Snx16
Food seeking constrained by brief footshock 16.7 1 0 0.0 0.00 1.0e+00 Snx16
Run reversals in cocaine runway, males 39.3 1 1 1.1 0.00 1.0e+00 NA
Latency to leave start box in cocaine runway 18.8 1 0 0.0 0.00 1.0e+00 NA
Cd content in liver 140.5 1 1 1.1 0.00 1.0e+00 NA
Co content in liver 83.2 1 1 1.1 0.00 1.0e+00 NA
K content in liver 62.6 1 1 1.1 0.00 1.0e+00 NA
Mn content in liver 130.2 1 1 1.1 0.00 1.0e+00 NA
Rb content in liver 31.4 1 1 1.1 0.00 1.0e+00 NA
Se content in liver 47.0 1 1 1.1 0.00 1.0e+00 NA
Zn content in liver 46.0 1 1 1.1 0.00 1.0e+00 NA

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 45 2.1 4.0
Adipose alternative TSS 36 2.2 4.4
Adipose gene expression 154 1.9 4.1
Adipose isoform ratio 55 1.9 3.9
Adipose intron excision ratio 34 1.2 3.4
Adipose mRNA stability 62 1.8 3.8
BLA alternative polyA 24 2.0 4.3
BLA alternative TSS 16 1.9 4.0
BLA gene expression 121 2.0 4.1
BLA isoform ratio 34 1.9 4.4
BLA intron excision ratio 52 1.7 3.9
BLA mRNA stability 37 1.8 4.0
Brain alternative polyA 51 2.5 4.5
Brain alternative TSS 37 2.2 4.2
Brain gene expression 170 1.9 4.0
Brain isoform ratio 47 1.5 4.2
Brain intron excision ratio 108 2.0 4.0
Brain mRNA stability 86 2.0 3.9
Eye alternative polyA 3 1.7 3.8
Eye alternative TSS 3 1.2 4.1
Eye gene expression 21 1.9 3.9
Eye isoform ratio 6 1.7 4.4
Eye intron excision ratio 12 2.0 4.0
Eye mRNA stability 5 2.1 4.2
IL alternative polyA 21 3.4 4.8
IL alternative TSS 5 1.7 3.8
IL gene expression 66 1.8 3.8
IL isoform ratio 12 1.5 3.7
IL intron excision ratio 18 1.9 3.8
IL mRNA stability 25 2.3 4.2
LHb alternative polyA 10 1.7 3.9
LHb alternative TSS 13 3.7 4.2
LHb gene expression 58 1.8 3.8
LHb isoform ratio 13 1.7 3.8
LHb intron excision ratio 11 1.1 3.3
LHb mRNA stability 16 1.5 4.0
Liver alternative polyA 30 2.0 4.1
Liver alternative TSS 19 1.3 3.8
Liver gene expression 135 1.9 3.9
Liver isoform ratio 31 1.3 3.6
Liver intron excision ratio 93 2.1 3.8
Liver mRNA stability 61 2.5 4.0
NAcc alternative polyA 40 3.1 4.6
NAcc alternative TSS 15 1.6 4.0
NAcc gene expression 117 1.9 4.0
NAcc isoform ratio 37 2.0 4.4
NAcc intron excision ratio 63 2.1 4.0
NAcc mRNA stability 47 2.1 4.1
OFC alternative polyA 12 2.1 4.1
OFC alternative TSS 7 2.2 4.0
OFC gene expression 77 2.1 4.0
OFC isoform ratio 16 2.0 4.1
OFC intron excision ratio 31 3.1 4.4
OFC mRNA stability 26 2.4 4.2
PL alternative polyA 45 3.2 4.8
PL alternative TSS 47 4.0 4.8
PL gene expression 157 2.1 4.1
PL isoform ratio 54 2.4 4.4
PL intron excision ratio 73 2.0 3.9
PL mRNA stability 65 2.2 4.0

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.