Weight in grams of the extensor digitorum longus (EDL). Located in the anterior compartment of the leg, it extends the lateral four toes and also contributes to ankle dorsiflexion.
Tags: Physiology · Muscle
Project: lionikas_2014
2785 significantly associated models · 563 unique genes
| # | chr | p0 | p1 | # assoc genes | # joint models | best TWAS P | best SNP P | cond SNP P | % var exp | joint genes |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 1 | 171727837 | 174685359 | 3 | 1 | 1.7e-07 | 9.4e-07 | 2.5e-65 | -1111 | Rps15a |
| 2 | 1 | 176946412 | 178345186 | 1 | 1 | 3.1e-08 | 3.7e-07 | 1.4e-02 | 77 | Tnrc6a |
| 3 | 1 | 199398809 | 208295455 | 132 | 8 | 3.5e-10 | 1.2e-09 | 1.0e+00 | 100 | Tpcn2 Ganab Sf3b2 Cfl1 Ppp2r5b Tmem134 Ctsw Atg2a |
| 4 | 2 | 86361148 | 88973805 | 2 | 1 | 3.2e-10 | 1.6e-10 | 1.0e+00 | 100 | Ralyl |
| 5 | 2 | 89673058 | 95023945 | 16 | 1 | 1.8e-13 | 1.0e-13 | 1.0e+00 | 100 | Zfp704 |
| 6 | 2 | 97341393 | 99049575 | 2 | 1 | 8.4e-08 | 2.5e-08 | 1.0e+00 | 100 | Hnf4g |
| 7 | 2 | 99787494 | 102500927 | 6 | 1 | 1.9e-08 | 1.1e-08 | 1.2e-01 | 92 | Cyp7b1 |
| 8 | 2 | 225972996 | 228461478 | 7 | 1 | 8.3e-10 | 1.2e-12 | 1.1e-04 | 70 | Rap1gds1 |
| 9 | 4 | 146441482 | 149011707 | 7 | 1 | 1.5e-09 | 1.2e-09 | 1.4e-01 | 94 | Slc6a11 |
| 10 | 5 | 54563228 | 57839987 | 7 | 2 | 8.2e-08 | 2.1e-08 | 8.8e-02 | 91 | Ddx58 Aptx |
| 11 | 6 | 129055047 | 132888501 | 37 | 4 | 3.4e-12 | 5.1e-11 | 1.0e+00 | 100 | Siva1 Inf2 Cep170b Tedc1 |
| 12 | 7 | 29535 | 2057232 | 31 | 4 | 1.5e-07 | 1.5e-07 | 1.0e+00 | 100 | Ikzf4 Rab5b Dnajc14 Sarnp |
| 13 | 7 | 16845355 | 16970279 | 1 | 1 | 4.6e-36 | NaN | NA | NA | NA |
| 14 | 7 | 83305298 | 85971312 | 3 | 2 | 6.8e-08 | 5.9e-08 | 0.0e+00 | -8766 | Med30 NA |
| 15 | 7 | 87430397 | 88835787 | 2 | 1 | 4.2e-08 | 7.7e-10 | 1.0e+00 | 100 | Has2 |
| 16 | 7 | 127692699 | 129997098 | 8 | 2 | 7.5e-08 | 1.1e-07 | 1.0e+00 | 100 | Slc48a1 Rapgef3 |
| 17 | 7 | 130474807 | 134497678 | 35 | 6 | 6.0e-11 | 9.7e-09 | 1.0e+00 | 100 | Dazap2 Scn8a Csad Krt80 Galnt6 Krt71 |
| 18 | 8 | 69336832 | 75537324 | 30 | 6 | 2.7e-09 | 1.7e-09 | 1.0e+00 | 100 | Rsl24d1 Ccpg1 Unc13c Myzap Nedd4 Pigb |
| 19 | 9 | 41500976 | 42900083 | 1 | 1 | 3.4e-07 | 2.6e-07 | 1.0e+00 | 100 | Map4k4 |
| 20 | 9 | 44247541 | 50043612 | 31 | 10 | 9.3e-12 | 8.1e-12 | 1.0e+00 | 100 | Wdr75 Osgepl1 Tpp2 Nemp2 Mrps9 RGD1310553 Fhl2 Nck2 Ercc5 Ormdl1 |
| 21 | 10 | 58773413 | 61500745 | 15 | 1 | 2.7e-08 | 2.3e-08 | 1.0e+00 | 100 | Crk |
| 22 | 10 | 81422075 | 86251828 | 46 | 8 | 1.0e-11 | 1.5e-10 | NaN | NaN | Krt15 Rpl19 Thra Rara Igfbp4 Srcin1 Ormdl3 Stard3 |
| 23 | 10 | 87148755 | 89011911 | 6 | 3 | 8.9e-08 | 1.7e-07 | 1.0e+00 | 100 | Gfap Acbd4 Arhgap27 |
| 24 | 10 | 90210853 | 92351292 | 6 | 1 | 4.4e-09 | 3.4e-07 | 3.9e-01 | 97 | Map3k3 |
| 25 | 12 | 27006 | 4653252 | 12 | 6 | 1.0e-08 | 7.1e-08 | 1.0e+00 | 100 | Trappc5 Cers4 N4bp2l2 Insr Pet100 Zfp958 |
| 26 | 14 | 8196668 | 10268633 | 7 | 1 | 7.4e-08 | 1.9e-07 | 4.7e-01 | 98 | Lin54 |
| 27 | 14 | 16470695 | 22686240 | 33 | 5 | 1.6e-16 | 1.6e-15 | NaN | NaN | Alb Gc Slc4a4 Rufy3 Adamts3 |
| 28 | 15 | 35796833 | 43041493 | 41 | 7 | 3.8e-13 | 3.2e-13 | 1.0e+00 | 100 | Dleu7 Gucy1b2 NA Msra Gulo Chrna2 Ptk2b |
| 29 | 15 | 43349498 | 46640839 | 28 | 6 | 2.3e-13 | 5.5e-13 | 1.0e+00 | 100 | Sorbs3 Phyhip Lgi3 Nudt18 R3hcc1 Egr3 |
| 30 | 15 | 47167781 | 49440043 | 7 | 1 | 2.1e-11 | 7.8e-13 | 4.1e-03 | 84 | Fndc3a |
p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.
| Trait | chisq ratio | # genes+ | # genes++ | % genes++ | corr | corr P | genes |
|---|
chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.
| tissue | modality | # hits | % hits/tests | avg chisq |
|---|
tissue | modality | # hits | % hits/tests | avg chisq |
|---|---|---|---|---|
| IL | alternative polyA | 21 | 3.4 | 4.8 |
| PL | alternative polyA | 45 | 3.2 | 4.8 |
| PL | alternative TSS | 47 | 4.0 | 4.8 |
| NAcc | alternative polyA | 40 | 3.1 | 4.6 |
| Brain | alternative polyA | 51 | 2.5 | 4.5 |
| Adipose | alternative TSS | 36 | 2.2 | 4.4 |
| BLA | isoform ratio | 34 | 1.9 | 4.4 |
| Eye | isoform ratio | 6 | 1.7 | 4.4 |
| NAcc | isoform ratio | 37 | 2.0 | 4.4 |
| OFC | intron excision ratio | 31 | 3.1 | 4.4 |
| PL | isoform ratio | 54 | 2.4 | 4.4 |
| BLA | alternative polyA | 24 | 2.0 | 4.3 |
| Brain | alternative TSS | 37 | 2.2 | 4.2 |
| Brain | isoform ratio | 47 | 1.5 | 4.2 |
| Eye | mRNA stability | 5 | 2.1 | 4.2 |
| IL | mRNA stability | 25 | 2.3 | 4.2 |
| LHb | alternative TSS | 13 | 3.7 | 4.2 |
| OFC | mRNA stability | 26 | 2.4 | 4.2 |
| Adipose | gene expression | 154 | 1.9 | 4.1 |
| BLA | gene expression | 121 | 2.0 | 4.1 |
| Eye | alternative TSS | 3 | 1.2 | 4.1 |
| Liver | alternative polyA | 30 | 2.0 | 4.1 |
| NAcc | mRNA stability | 47 | 2.1 | 4.1 |
| OFC | alternative polyA | 12 | 2.1 | 4.1 |
| OFC | isoform ratio | 16 | 2.0 | 4.1 |
| PL | gene expression | 157 | 2.1 | 4.1 |
| Adipose | alternative polyA | 45 | 2.1 | 4.0 |
| BLA | alternative TSS | 16 | 1.9 | 4.0 |
| BLA | mRNA stability | 37 | 1.8 | 4.0 |
| Brain | gene expression | 170 | 1.9 | 4.0 |
| Brain | intron excision ratio | 108 | 2.0 | 4.0 |
| Eye | intron excision ratio | 12 | 2.0 | 4.0 |
| LHb | mRNA stability | 16 | 1.5 | 4.0 |
| Liver | mRNA stability | 61 | 2.5 | 4.0 |
| NAcc | alternative TSS | 15 | 1.6 | 4.0 |
| NAcc | gene expression | 117 | 1.9 | 4.0 |
| NAcc | intron excision ratio | 63 | 2.1 | 4.0 |
| OFC | alternative TSS | 7 | 2.2 | 4.0 |
| OFC | gene expression | 77 | 2.1 | 4.0 |
| PL | mRNA stability | 65 | 2.2 | 4.0 |
| Adipose | isoform ratio | 55 | 1.9 | 3.9 |
| BLA | intron excision ratio | 52 | 1.7 | 3.9 |
| Brain | mRNA stability | 86 | 2.0 | 3.9 |
| Eye | gene expression | 21 | 1.9 | 3.9 |
| LHb | alternative polyA | 10 | 1.7 | 3.9 |
| Liver | gene expression | 135 | 1.9 | 3.9 |
| PL | intron excision ratio | 73 | 2.0 | 3.9 |
| Adipose | mRNA stability | 62 | 1.8 | 3.8 |
| Eye | alternative polyA | 3 | 1.7 | 3.8 |
| IL | alternative TSS | 5 | 1.7 | 3.8 |
| IL | gene expression | 66 | 1.8 | 3.8 |
| IL | intron excision ratio | 18 | 1.9 | 3.8 |
| LHb | gene expression | 58 | 1.8 | 3.8 |
| LHb | isoform ratio | 13 | 1.7 | 3.8 |
| Liver | alternative TSS | 19 | 1.3 | 3.8 |
| Liver | intron excision ratio | 93 | 2.1 | 3.8 |
| IL | isoform ratio | 12 | 1.5 | 3.7 |
| Liver | isoform ratio | 31 | 1.3 | 3.6 |
| Adipose | intron excision ratio | 34 | 1.2 | 3.4 |
| LHb | intron excision ratio | 11 | 1.1 | 3.3 |
avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.