Hub : Genes

Pmp2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	Pmp2	0.09	0.06	5.6e-08	0.06	0.06	0.05	0.06	1.1e-06	8.2e-07	1.4e-06	7.2e-07
2	NAcc	gene expression	Pmp2	0.07	0.05	2.3e-10	0.06	0.06	0.05	0.06	1.3e-09	1.5e-09	1.4e-08	2.3e-09
3	BLA	gene expression	Pmp2	0.09	0.06	3.3e-04	0.03	0.02	0.03	0.01	8.4e-03	2.4e-02	1.2e-02	6.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	1.1	2.0	2.2	-1.3	1.5	1.4
Area under the delay curve	0.7	1.0	1.3	1.1	-0.9	-1.0
BMI with tail	0.7	2.6	2.8	1.7	-1.7	-1.5
BMI without tail	0.7	3.8	4.6	1.9	-2.1	-1.8
Body weight	1.1	4.8	5.4	2.3	-2.2	-2.0
Weight adjusted by age	0.1	0.3	0.4	0.3	-0.7	-0.5
Bone surface	1.5	3.0	3.6	-1.7	1.6	1.9
Bone volume	1.2	2.4	2.7	-1.6	1.5	1.6
Breakpoint value in progressive ratio session	0.6	1.1	1.4	0.9	-1.1	-1.2
Number of licking bursts	0.1	0.4	0.5	-0.7	0.6	0.6
Context. condit. distance diff. score	0.0	0.0	0.0	0.2	0.2	-0.0
Locomotion velocity, session 1	2.6	2.9	3.7	1.9	-1.6	-1.6
Locomotion distance, session 1	1.2	1.5	2.0	1.4	-1.1	-1.1
Locomotion velocity, session 2	2.6	3.1	3.2	1.8	-1.7	-1.8
Locomotion distance, session 2	1.6	2.3	2.5	1.6	-1.4	-1.5
Locomotion velocity, session 3	0.0	0.0	0.0	0.1	0.1	0.0
Locomotion distance, session 3	0.3	0.3	0.4	-0.5	0.6	0.4
Stereotopy head waving bouts, day 3	0.1	0.1	0.1	0.4	-0.3	-0.3
Stereotopy head waving duration, day 3	0.5	0.7	0.8	0.9	-0.8	-0.7
Locomotion velocity, session 7	4.1	4.5	4.9	-2.0	2.1	2.2
Locomotion distance, session 7	5.1	6.5	6.8	-2.5	2.5	2.6
Stereotopy head waving bouts, day 7	0.9	1.1	1.1	1.0	-1.0	-1.1
Stereotopy head waving duration, day 7	1.3	1.6	1.6	1.3	-1.2	-1.3
Locomotion velocity, session 8	4.0	4.9	5.7	2.4	-2.0	-2.2
Locomotion distance, session 8	1.1	1.6	2.4	1.5	-1.0	-1.2
Degree of sensitization distance	0.4	0.4	0.6	-0.6	0.6	0.8
Degree of sensitization stereotypy	2.0	2.2	2.3	1.5	-1.5	-1.5
Conditioned locomotion	0.2	0.2	0.2	0.5	-0.4	-0.5
Cocaine response after cond. corrected	0.7	1.0	1.0	-1.0	1.0	1.0
Cocaine response after cond. not corrected	1.2	1.8	1.8	-1.3	1.4	1.3
Cocaine response before conditioning	0.2	0.2	0.3	-0.6	0.5	0.4
Saline control response	0.2	0.3	0.4	-0.5	0.5	0.6
Bone: connectivity density	1.7	2.8	3.4	-1.4	1.7	1.8
Bone: cortical apparent density	0.8	1.3	1.4	1.2	-1.0	-1.2
Bone: cortical area	0.2	0.4	0.7	0.3	-0.9	-0.5
Bone: cortical porosity	0.0	0.0	0.1	-0.3	-0.0	0.1
Bone: cortical porosity	0.0	0.0	0.1	0.0	-0.3	-0.2
Bone: cortical thickness	0.7	1.2	1.6	0.9	-1.3	-1.1
Bone: cortical thickness	5.0	6.1	7.3	2.2	-2.7	-2.5
Bone: cortical tissue density	0.8	1.2	1.4	1.2	-1.0	-1.2
Condit. Reinf. active minus inactive responses	5.6	6.3	6.6	2.4	-2.6	-2.6
Condit. Reinf. active-inactive response ratio	7.2	7.8	8.1	2.7	-2.9	-2.8
Condit. Reinf. active responses	4.0	5.2	5.4	2.2	-2.3	-2.3
Condit. Reinf. inactive responses	0.0	0.1	0.1	0.2	-0.3	-0.2
Incentive salience index mean	5.4	6.9	7.2	2.6	-2.7	-2.7
Condit. Reinf. lever presses	2.4	3.6	4.1	2.0	-1.9	-1.8
Condit. Reinf. active minus inactive responses	1.1	1.7	2.1	-1.5	1.1	1.3
Condit. Reinf. active-inactive response ratio	0.3	0.6	0.8	-0.9	0.6	0.7
Condit. Reinf. active responses	2.0	2.9	3.4	-1.8	1.5	1.7
Condit. Reinf. inactive responses	0.1	0.2	0.4	-0.4	0.4	0.6
Condit. Reinf. lever presses	0.8	1.1	1.5	-1.2	0.8	1.1
Condit. Reinf. lever reinforcers received	2.2	3.1	3.6	-1.9	1.6	1.8
Conditioned reinforcement - actives	1.7	6.6	7.7	-2.3	2.8	2.6
Conditioned reinforcement - inactives	0.1	0.4	0.6	-0.8	0.6	0.4
Conditioned locomotion	2.1	3.1	4.0	-1.5	2.0	1.7
Patch foraging indifference point 0 sec	0.5	1.5	1.6	-1.3	1.2	1.3
Patch foraging indifference point AUC	0.1	0.2	0.3	0.5	-0.5	-0.5
Delay disc. indifference point, 0s delay	0.2	0.2	0.3	0.0	0.6	0.5
Delay disc. indifference point, 16s delay	0.5	0.7	0.9	0.8	-0.9	-0.8
Delay disc. indifference point, 2s delay	0.9	1.0	1.7	1.3	-0.7	-0.9
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	0.1	-0.4	-0.5
Delay disc. indifference point, 4s delay	2.0	2.1	2.4	1.6	-1.2	-1.5
Delay disc. indifference point, 8s delay	0.1	0.1	0.2	0.2	-0.2	-0.4
Indifference point function ln k	0.0	0.0	0.0	0.1	0.1	0.1
Indifference point function log k	0.0	0.0	0.0	0.1	0.1	0.1
Patch foraging total patch changes 0 sec	0.3	0.9	1.0	-1.0	0.9	0.9
Patch foraging total patch changes 12 sec	0.3	0.4	0.5	-0.7	0.5	0.5
Patch foraging total patch changes 18 sec	0.3	0.6	0.8	0.7	-0.9	-0.8
Patch foraging total patch changes 24 sec	0.0	0.1	0.1	0.0	0.3	0.3
Patch foraging total patch changes 6 sec	0.0	0.0	0.0	0.1	-0.1	-0.1
Patch foraging time to switch 0 sec	0.5	2.0	2.2	1.4	-1.4	-1.5
Patch foraging water rate 0 sec	0.0	0.1	0.2	-0.3	0.2	0.4
Patch foraging water rate 12 sec	0.6	2.5	2.7	-1.6	1.4	1.6
Patch foraging water rate 18 sec	0.2	0.4	0.5	-0.7	0.6	0.7
Patch foraging water rate 24 sec	0.0	0.1	0.1	-0.1	0.1	0.4
Patch foraging water rate 6 sec	2.2	3.2	3.6	-1.8	1.7	1.9
Seeking ratio, delayed vs. immediate footshock	8.0	11.4	11.9	-3.3	3.5	3.4
Distance traveled before self-admin	0.3	0.7	1.2	1.1	-0.6	-0.8
Distance traveled after self-admin	0.0	0.1	0.1	-0.3	0.3	0.3
Extensor digitorum longus weight	11.2	44.9	49.4	7.0	-6.5	-6.5
Bone: elastic displacement	0.0	0.0	0.1	0.2	-0.1	-0.3
Bone: elastic work	0.0	0.0	0.0	0.0	-0.1	-0.1
Bone: endosteal estimation	0.2	0.5	0.7	-0.7	0.6	0.8
Bone: endosteal perimeter	0.3	0.7	0.9	-0.9	0.6	0.9
Epididymis fat weight	0.2	1.2	2.2	1.5	-0.8	-0.9
Delta time in closed arm before/after self-admin	0.1	0.1	0.1	0.0	0.4	0.2
Delta time in open arm before/after self-admin	0.2	0.2	0.3	-0.5	0.4	0.5
Diff in mean of infusions in LGA sessions	1.1	1.9	2.1	1.2	-1.5	-1.4
Delay discount exponential model param	0.6	0.9	1.0	-1.0	0.8	1.0
Extinction: sum of active levers before priming	0.1	0.1	0.2	0.2	-0.3	-0.5
Active lever presses in extinction session 6	0.1	0.1	0.1	-0.3	0.4	0.2
Bone: final force	0.3	0.5	0.9	0.4	-0.9	-0.6
Bone: final moment	0.1	0.1	0.2	0.0	-0.5	-0.2
Food consumed during 24 hour testing period	1.4	2.8	3.0	1.7	-1.6	-1.7
Glucose	1.4	2.2	2.4	1.4	-1.5	-1.5
Heart weight	0.3	0.6	0.7	0.8	-0.8	-0.7
Delay discount hyperbolic model param	1.1	1.5	1.8	-1.3	1.1	1.2
Intermittent access intake day 1-15 change	0.9	4.7	5.2	-2.3	2.2	2.1
Intermittent access intake escalation	1.0	5.7	5.9	-2.4	2.4	2.3
Intermittent access intake escalation 2	4.5	7.6	7.8	-2.8	2.8	2.7
Intermitt. access day 1 inactive lever presses	0.2	1.9	2.1	1.3	-1.4	-1.4
Intermitt. access day 15 inactive lever presses	0.0	0.2	0.3	0.1	-0.5	-0.6
Intermitt. access escalation Index	0.1	0.5	0.6	0.6	-0.8	-0.6
Intermittent access day 1 total infusions	1.2	3.5	4.8	-2.2	1.8	1.6
Intermittent access day 15 total infusions	4.7	11.4	13.0	-3.6	3.4	3.2
Intermittent access terminal intake (last 3 days)	6.7	11.7	15.5	-3.9	3.2	3.0
Intermittent access total infusions	5.9	7.0	8.9	-3.0	2.6	2.4
Intermittent access day 1 locomotion	0.7	1.2	2.1	-1.4	1.0	0.8
Intermittent access day 15 total locomotion	0.3	1.1	2.0	-1.4	0.9	0.6
Intermittent access total locomotion	2.1	2.5	4.1	-2.0	1.4	1.1
Intermittent access standard deviation	1.5	7.7	8.2	-2.9	2.8	2.6
Left kidney weight	0.0	0.2	0.2	-0.5	0.3	0.5
Right kidney weight	0.0	0.2	0.3	0.5	-0.6	-0.4
Cocaine induced anxiety	0.2	0.5	0.6	0.6	-0.7	-0.8
Post-drug Anxiety	2.1	2.4	3.1	1.8	-1.4	-1.5
Baseline Anxiety	0.2	0.3	0.5	0.7	-0.5	-0.4
Tail length	0.4	2.0	2.0	1.4	-1.4	-1.4
Length with tail	0.3	1.4	1.8	1.4	-1.1	-1.0
Length without tail	0.0	0.1	0.2	0.0	0.4	0.4
Times rat made contact with spout	0.1	0.1	0.1	-0.4	0.2	0.2
Lifetime Intake	4.8	5.9	7.5	-2.7	2.4	2.1
Liver weight, left	0.5	0.9	1.0	1.0	-1.0	-0.8
Liver weight, right	0.1	0.1	0.3	0.3	-0.5	-0.2
Locomotor activity	0.0	0.1	0.1	0.4	0.1	0.1
Locomotor testing distance	0.0	0.1	0.2	0.4	0.1	-0.1
Locomotor testing rearing	0.4	1.4	1.7	-1.0	1.3	1.1
Locomotion in novel chamber	0.8	1.1	1.1	1.0	-1.1	-1.0
Locomotion in novel chamber post-restriction	0.0	0.0	0.0	0.0	-0.1	0.2
Fecal boli incidents, locomotor time 1	0.1	0.3	0.5	0.5	-0.4	-0.7
Change in fecal boli incidents, locomotor task	3.2	3.4	4.4	-1.7	1.7	2.1
Time >=10cm from walls, locomotor time 1	0.8	1.0	1.2	-1.0	1.1	0.8
Bouts of movement, locomotor time 1	0.0	0.1	0.1	-0.1	0.4	0.2
Total resting periods, locomotor time 1	0.1	0.1	0.2	-0.1	0.5	0.4
Rest time, locomotor task time 1	0.1	0.2	0.5	-0.1	0.3	0.7
Distance moved, locomotor task time 1	0.1	0.2	0.4	0.1	-0.3	-0.6
Vertical activity count, locomotor time 1	0.0	0.1	0.2	0.1	-0.2	-0.4
Time >=10cm from walls, locomotor time 2	0.1	0.3	0.5	-0.7	0.4	0.6
Bouts of movement, locomotor time 2	0.1	0.3	0.5	0.7	-0.6	-0.4
Total resting periods, locomotor time 2	0.1	0.3	0.6	0.8	-0.6	-0.4
Rest time, locomotor task time 2	0.1	0.1	0.3	0.5	-0.4	-0.1
Distance moved, locomotor task time 2	0.0	0.1	0.1	-0.3	-0.1	-0.3
Vertical activity count, locomotor time 2	0.7	1.5	1.9	1.0	-1.3	-1.4
Light reinforcement 1	0.4	1.8	2.2	1.1	-1.4	-1.5
Light reinforcement 2	2.0	4.5	5.3	1.9	-2.3	-2.2
Bone: marrow area	0.1	0.3	0.5	-0.6	0.4	0.7
Bone: maximum diameter	0.0	0.1	0.1	-0.3	-0.3	0.1
Bone: maximum force	0.1	0.3	0.5	0.3	-0.7	-0.5
Bone: maximum moment	0.0	0.0	0.0	-0.1	-0.2	-0.0
Mean time between licks in bursts	0.1	0.8	0.9	0.9	-0.8	-0.9
Mean num. licks in bursts	0.1	0.2	0.2	0.4	-0.3	-0.4
Cd content in liver	0.6	0.6	0.8	0.7	-0.8	-0.9
Co content in liver	0.0	0.1	0.1	0.3	-0.3	-0.1
Cu content in liver	3.3	3.9	4.1	-2.0	2.0	1.9
Fe content in liver	0.5	0.6	0.7	-0.8	0.7	0.7
K content in liver	0.7	0.7	0.9	-0.7	0.8	1.0
Mg content in liver	0.7	0.8	0.9	-0.8	0.9	0.9
Mn content in liver	0.0	0.0	0.1	0.3	0.1	0.1
Na content in liver	1.1	1.2	1.5	-1.2	0.8	1.2
Rb content in liver	0.0	0.0	0.0	-0.1	0.0	0.1
Se content in liver	0.0	0.1	0.1	-0.1	0.3	0.2
Sr content in liver	0.2	0.1	0.2	0.5	0.4	0.1
Zn content in liver	3.0	3.5	3.5	-1.9	1.9	1.9
Bone: minimum diameter	0.4	0.7	1.0	0.7	-1.0	-0.8
Time in familiar zone, hab. session 1	0.5	0.5	0.7	-0.5	0.8	0.9
Time in novel zone, hab. session 1	0.1	0.1	0.2	-0.1	-0.2	-0.4
Total zone transitions, hab. session 1	1.2	1.7	2.1	1.5	-1.2	-1.2
Total locomotion distance, hab. session 1	0.3	0.4	0.5	0.7	-0.6	-0.6
Locomotion velocity, hab. session 1	0.8	1.1	1.2	1.1	-1.0	-1.0
Time in familiar zone, hab. session 2	1.4	1.6	1.8	-1.1	1.3	1.4
Time in novel zone, hab. session 2	0.4	0.4	0.6	0.4	-0.7	-0.7
Total zone transitions, hab. session 2	0.4	0.5	1.0	1.0	-0.5	-0.6
Total locomotion distance, hab. session 2	0.2	0.3	0.4	0.6	-0.4	-0.6
Locomotion velocity, hab. session 2	0.1	0.2	0.3	0.5	-0.3	-0.4
Novel to familiar place preference ratio	0.0	0.0	0.0	-0.1	-0.1	-0.1
Novelty place preference	0.0	0.0	0.1	-0.3	0.1	0.0
Time in novel zone, NPP test	0.0	0.0	0.0	-0.2	-0.0	-0.1
Total zone transitions, NPP test	1.0	1.5	2.6	1.6	-0.9	-1.0
Total locomotion distance, NPP test	0.4	0.6	0.8	0.9	-0.6	-0.8
Locomotion velocity, NPP test	0.2	0.2	0.4	0.6	-0.3	-0.5
Intraocular pressure	2.1	3.4	3.8	2.0	-1.9	-1.7
Delta distance traveled before/after self-admin	3.6	4.0	4.9	-2.2	1.8	1.9
Delta ambulatory time before/after self-admin	2.4	4.2	5.2	-2.3	1.9	1.9
Parametrial fat weight	0.1	0.2	0.2	0.4	-0.4	-0.4
Pavlov. Cond. lever latency	0.5	0.6	0.7	-0.8	0.7	0.8
Pavlov. Cond. magazine entry latency	0.3	0.4	0.4	0.6	-0.6	-0.6
Pavlov. Cond. change in total contacts	2.6	2.8	3.1	1.7	-1.6	-1.8
Pavlov. Cond. index score	0.8	1.0	1.1	1.0	-0.9	-1.0
Pavlov. Cond. latency score	0.7	0.9	1.0	1.0	-0.8	-1.0
Pavlov. Cond. lever contacts	0.5	0.6	0.8	0.9	-0.7	-0.8
Pavlov. Cond. magazine entry number	0.9	1.2	1.2	-1.1	1.0	1.1
Pavlov. Cond. intertrial magazine entries	0.5	0.6	0.7	-0.7	0.8	0.9
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.8	0.9	1.0	-0.8	-1.0
Pavlov. Cond. response bias	0.7	0.9	1.1	1.0	-0.9	-1.0
Pavlov. Cond. lever latency	1.1	1.6	1.8	1.4	-1.1	-1.3
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	-0.1	-0.3	-0.1
Pavlov. Cond. change in total contacts	0.0	0.0	0.0	-0.2	-0.1	0.2
Pavlov. Cond. index score	0.1	0.1	0.2	-0.4	0.0	0.3
Pavlov. Cond. latency score	0.2	0.3	0.4	-0.7	0.2	0.5
Pavlov. Cond. lever contacts	0.6	0.9	1.1	-1.0	0.7	1.1
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	-0.1	0.5	0.2
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.4	0.6	-0.3	-0.4
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	-0.5	0.1	0.4
Pavlov. Cond. response bias	0.2	0.2	0.4	-0.6	0.2	0.5
Time in closed arm before self-admin	0.8	1.3	1.8	-1.3	1.1	1.0
Time in closed arm after self-admin	0.3	0.3	0.4	-0.5	0.6	0.5
Time in open arm before self-admin	0.0	0.0	0.0	0.2	-0.1	-0.2
Time in open arm after self-admin	0.4	0.5	0.6	0.8	-0.7	-0.5
Bone: periosteal estimation	0.0	0.1	0.3	0.0	-0.5	-0.2
Bone: periosteal perimeter	0.1	0.1	0.2	-0.4	0.0	0.4
Bone: post-yield work	3.0	5.1	5.5	-2.3	2.1	2.3
Progressive ratio test 1 active lever presses	1.3	2.3	3.4	-1.8	1.5	1.2
Progressive ratio test 1 breakpoint	1.4	2.4	3.5	-1.9	1.5	1.3
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.1	-0.3	0.1	-0.1
Progressive ratio test 2 active lever presses	4.2	6.0	6.3	-2.5	2.5	2.4
Progressive ratio test 2 breakpoint	4.4	5.6	5.9	-2.4	2.4	2.3
Progressive ratio test 2 inactive lever presses	0.6	1.8	2.8	-1.7	1.2	1.1
Incentive Sensitization - Responses	1.0	2.9	3.1	-1.6	1.8	1.7
Incentive Sensitization - Breakpoint	1.3	3.0	3.3	-1.6	1.8	1.8
Sum of active levers in priming session hrs 5-6	0.5	0.5	0.6	-0.6	0.7	0.7
Progressive ratio	0.3	0.9	1.3	-1.1	1.0	0.7
Food seeking constrained by brief footshock	3.4	4.2	4.7	2.2	-2.0	-2.0
Seeking ratio, punishment vs. effort	1.7	3.8	4.9	2.2	-1.9	-1.7
Retroperitoneal fat weight	0.2	0.9	1.3	1.2	-0.9	-0.8
Reaction time number correct	0.1	0.4	0.5	-0.7	0.6	0.7
Reaction time mean minus median	0.7	4.3	5.4	1.7	-2.3	-2.2
Reaction time mean minus median AUC	0.8	5.6	6.6	1.9	-2.6	-2.5
Reaction time num false alarms	0.8	1.4	1.6	-1.3	1.2	1.2
Reaction time num false alarms AUC	0.7	1.7	1.9	-1.4	1.3	1.2
Reaction time trials correct on left	0.1	0.4	0.5	-0.7	0.6	0.7
Reaction time trials on left	0.1	0.3	0.4	-0.6	0.5	0.6
Reaction time mean	1.6	3.5	4.5	1.6	-1.9	-2.1
Reaction time mean AUC	1.6	3.7	4.9	1.6	-2.0	-2.2
Median of all reaction times	1.6	2.5	3.4	1.3	-1.5	-1.8
Reaction time omissions	4.7	7.6	8.6	2.5	-2.9	-2.8
Reaction time false alarm rate	0.3	0.4	0.5	-0.7	0.6	0.6
Reaction time premature initiation rate	1.5	2.3	2.4	-1.5	1.6	1.5
Reaction time premature initiations	0.9	2.7	2.7	-1.7	1.6	1.6
Std. dev. reaction times	0.8	2.8	3.5	1.2	-1.9	-1.9
Reaction time trials completed	0.1	0.3	0.4	-0.6	0.5	0.6
Reaction time trials AUC	0.1	0.2	0.2	-0.5	0.4	0.5
Run reversals in cocaine runway, females	0.6	0.6	0.8	0.9	-0.7	-0.8
Run reversals in cocaine runway, males	2.4	2.7	2.8	1.7	-1.7	-1.6
Latency to leave start box in cocaine runway	0.7	1.0	1.1	-1.0	1.0	1.0
Latency to leave start box in cocaine runway, F	3.2	4.0	4.2	-1.9	2.0	2.1
Latency to leave start box in cocaine runway, M	2.9	2.8	3.0	1.6	-1.7	-1.7
Std. dev. time between licks in bursts	0.0	0.0	0.0	0.0	0.1	0.1
Total sessions with >9 infusions	1.8	2.3	3.2	-1.8	1.5	1.2
Short access day 1 total inactive lever presses	0.7	1.4	1.9	-1.4	1.1	1.0
Short access day 10 total inactive lever presses	0.0	0.2	0.4	0.6	-0.3	-0.1
Short access day 1 total infusions	1.3	2.6	2.9	-1.7	1.7	1.5
Short access day 10 total infusions	2.2	3.6	4.4	-2.1	1.9	1.7
Short access total infusions	1.8	2.5	3.5	-1.9	1.5	1.3
Short access day 1 locomotion	0.2	0.3	0.6	-0.8	0.4	0.2
Short access day 10 total locomotion	0.1	0.4	0.7	0.4	-0.6	-0.8
Short access total locomotion	0.3	0.5	1.0	-1.0	0.6	0.4
One hour access (0.3 mA shock)	6.5	7.7	8.0	-2.8	2.8	2.7
Compulsive drug intake	0.4	0.6	1.2	1.1	-0.6	-0.5
One hour access (shock baseline)	4.4	11.5	14.5	-3.8	3.3	3.1
Social response proportion	0.3	0.4	0.7	0.5	-0.8	-0.5
Social responses	0.7	0.9	1.2	0.8	-1.1	-0.9
Social time	0.1	0.1	0.1	-0.3	-0.2	-0.3
Soleus weight	1.1	3.1	3.3	1.7	-1.7	-1.8
Bone: stiffness	0.2	0.3	0.5	0.4	-0.7	-0.5
Tibialis anterior weight	9.3	32.0	35.0	5.9	-5.4	-5.6
Time to tail flick, vehicle, before self-admin	0.3	0.4	0.5	-0.4	0.7	0.6
Time to tail flick, vehicle, after self-admin	1.8	3.7	4.1	-1.8	1.9	2.0
Time to tail flick, test, before self-admin	0.0	0.0	0.0	-0.0	0.1	0.2
Time to tail flick, test, after self-admin	1.5	1.6	2.7	-1.6	1.0	1.0
Delta time to tail flick, vehicle, before/after SA	2.8	3.0	3.7	-1.9	1.7	1.6
Delta time to tail flick, test, before/after SA	0.1	0.1	0.1	-0.2	-0.3	-0.3
Tibia length	1.3	3.6	4.1	-1.8	1.8	2.0
Ambulatory time before self-admin	0.5	1.6	2.2	1.5	-1.0	-1.2
Ambulatory time after self-admin	0.3	0.4	0.5	-0.7	0.7	0.6
Bone: tissue strength	3.0	3.1	3.2	-1.8	1.8	1.8
Total heroin consumption	0.1	0.1	0.1	-0.3	0.3	0.2
Bone: trabecular number	0.5	0.9	1.0	-0.9	1.0	0.9
Bone: trabecular spacing	1.0	1.5	1.8	1.2	-1.3	-1.2
Bone: trabecular thickness	1.3	1.7	2.1	-1.5	1.3	1.1
Bone: trabecular tissue density	2.7	4.7	5.4	1.9	-2.3	-2.3
Water consumed over 24 hours	0.1	0.2	0.2	0.4	-0.4	-0.5
Number of responses in last shaping day	0.5	0.7	1.1	-1.1	0.7	0.7