Hub : Genes

Pmp2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	gene expression	Pmp2	0.1	0.07	3.3e-04	0.04	0.01	0.01	0.01	2.6e-03	4.9e-02	9.9e-02	7.2e-02
2	PL	gene expression	Pmp2	0.1	0.06	1.6e-08	0.06	0.06	0.06	0.06	2.8e-07	6.5e-07	5.8e-07	8.2e-07
3	NAcc	gene expression	Pmp2	0.09	0.06	5.6e-09	0.05	0.06	0.06	0.06	7.8e-07	5.6e-08	1.4e-07	3.0e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	1.2	2.0	2.7	1.6	1.6	-0.9
Area under the delay curve	0.9	1.0	1.3	-1.0	-1.1	0.7
BMI with tail	2.3	7.3	9.3	-2.6	-2.4	3.0
BMI without tail	5.6	11.7	12.2	-3.5	-3.3	3.5
Body weight	0.9	3.6	4.5	-1.8	-1.8	2.1
Weight adjusted by age	0.3	0.3	0.5	-0.5	-0.7	0.5
Bone surface	1.7	3.0	4.2	2.1	2.0	-0.7
Bone volume	1.5	2.6	3.9	2.0	1.9	-0.7
Breakpoint value in progressive ratio session	1.8	1.9	2.1	-1.5	-1.3	1.4
Number of licking bursts	0.3	0.4	0.5	0.7	0.6	-0.4
Context. condit. distance diff. score	0.0	0.0	0.1	-0.2	-0.1	-0.3
Locomotion velocity, session 1	2.7	2.9	3.1	-1.7	-1.7	1.6
Locomotion distance, session 1	1.3	1.7	2.2	-1.2	-1.3	1.5
Locomotion velocity, session 2	2.3	2.7	3.0	-1.5	-1.7	1.6
Locomotion distance, session 2	1.8	2.6	3.7	-1.3	-1.5	1.9
Locomotion velocity, session 3	0.0	0.0	0.0	0.0	0.0	-0.2
Locomotion distance, session 3	0.1	0.2	0.3	0.5	0.4	-0.1
Stereotopy head waving bouts, day 3	0.3	0.3	0.6	-0.5	-0.3	0.8
Stereotopy head waving duration, day 3	0.7	0.8	1.0	-1.0	-0.8	0.9
Locomotion velocity, session 7	3.0	3.3	4.7	2.2	2.1	-0.8
Locomotion distance, session 7	3.8	4.8	5.8	2.4	2.4	-1.7
Stereotopy head waving bouts, day 7	0.7	0.8	1.1	-0.8	-0.9	1.1
Stereotopy head waving duration, day 7	1.1	1.3	1.5	-1.2	-1.2	1.0
Locomotion velocity, session 8	3.8	4.5	5.3	-2.2	-2.3	1.8
Locomotion distance, session 8	1.2	1.8	2.0	-1.4	-1.4	1.3
Degree of sensitization distance	0.3	0.3	0.4	0.6	0.6	-0.5
Degree of sensitization stereotypy	1.8	1.9	2.1	-1.4	-1.5	1.3
Conditioned locomotion	0.2	0.2	0.2	-0.5	-0.5	0.5
Cocaine response after cond. corrected	1.0	1.1	1.2	1.1	1.0	-1.1
Cocaine response after cond. not corrected	1.8	1.9	2.3	1.5	1.3	-1.4
Cocaine response before conditioning	0.2	0.2	0.4	0.7	0.4	-0.2
Saline control response	0.6	0.8	1.2	1.0	1.1	-0.2
Bone: connectivity density	1.6	2.6	3.3	1.7	1.8	-1.2
Bone: cortical apparent density	0.6	0.8	1.3	-1.1	-0.9	0.6
Bone: cortical area	0.1	0.1	0.4	0.1	0.0	0.6
Bone: cortical porosity	0.1	0.1	0.2	-0.1	-0.0	0.5
Bone: cortical porosity	0.1	0.1	0.3	-0.3	-0.2	0.6
Bone: cortical thickness	0.4	0.7	1.3	-0.6	-0.6	1.1
Bone: cortical thickness	3.6	4.1	4.6	-1.9	-2.2	2.0
Bone: cortical tissue density	0.6	0.9	1.3	-1.1	-1.0	0.6
Condit. Reinf. active minus inactive responses	6.6	7.4	10.2	-2.4	-2.5	3.2
Condit. Reinf. active-inactive response ratio	8.6	9.3	12.5	-2.7	-2.8	3.5
Condit. Reinf. active responses	5.3	6.5	9.4	-2.2	-2.3	3.1
Condit. Reinf. inactive responses	0.1	0.1	0.1	-0.3	-0.3	0.4
Incentive salience index mean	6.8	8.2	11.3	-2.6	-2.6	3.4
Condit. Reinf. lever presses	2.8	3.7	4.8	-1.8	-1.7	2.2
Condit. Reinf. active minus inactive responses	1.3	1.6	2.4	1.6	1.5	-0.3
Condit. Reinf. active-inactive response ratio	0.6	0.6	1.1	1.1	0.9	0.1
Condit. Reinf. active responses	1.8	2.5	3.7	1.9	1.9	-0.5
Condit. Reinf. inactive responses	0.1	0.2	0.3	0.4	0.6	-0.2
Condit. Reinf. lever presses	0.7	0.9	1.5	1.2	1.1	-0.2
Condit. Reinf. lever reinforcers received	2.1	2.9	4.3	2.1	2.0	-0.6
Conditioned reinforcement - actives	4.1	4.1	5.2	2.3	2.3	-1.4
Conditioned reinforcement - inactives	0.1	0.1	0.4	0.2	0.6	-0.1
Conditioned locomotion	2.5	3.0	4.2	1.9	2.0	-1.1
Patch foraging indifference point 0 sec	1.1	1.7	2.1	1.4	1.1	-1.4
Patch foraging indifference point AUC	0.4	0.4	0.6	-0.7	-0.8	0.4
Delay disc. indifference point, 0s delay	0.1	0.1	0.1	0.2	0.1	-0.4
Delay disc. indifference point, 16s delay	1.0	1.0	1.4	-1.1	-1.2	0.7
Delay disc. indifference point, 2s delay	0.8	0.9	1.7	-0.8	-0.7	1.3
Delay disc. indifference point, 24s delay	0.0	0.0	0.1	-0.2	-0.3	0.0
Delay disc. indifference point, 4s delay	1.9	2.0	2.9	-1.4	-1.7	1.0
Delay disc. indifference point, 8s delay	0.0	0.0	0.1	-0.2	-0.2	-0.3
Indifference point function ln k	0.0	0.0	0.1	-0.2	-0.2	-0.0
Indifference point function log k	0.0	0.0	0.1	-0.2	-0.2	-0.0
Patch foraging total patch changes 0 sec	0.6	1.0	1.6	1.0	0.7	-1.3
Patch foraging total patch changes 12 sec	0.6	0.8	1.1	0.8	0.7	-1.1
Patch foraging total patch changes 18 sec	0.4	0.5	1.0	-0.5	-1.0	0.4
Patch foraging total patch changes 24 sec	0.2	0.3	0.6	0.5	0.1	-0.8
Patch foraging total patch changes 6 sec	0.0	0.1	0.1	-0.1	-0.2	-0.4
Patch foraging time to switch 0 sec	2.0	3.0	4.4	-1.6	-1.4	2.1
Patch foraging water rate 0 sec	0.2	0.4	0.8	0.4	0.2	-0.9
Patch foraging water rate 12 sec	1.5	2.3	2.7	1.6	1.3	-1.6
Patch foraging water rate 18 sec	0.6	0.8	1.0	1.0	1.0	-0.8
Patch foraging water rate 24 sec	0.2	0.3	0.6	0.2	0.4	-0.8
Patch foraging water rate 6 sec	2.4	3.6	3.9	2.0	1.9	-1.8
Seeking ratio, delayed vs. immediate footshock	9.5	10.9	11.3	3.4	3.4	-3.2
Distance traveled before self-admin	0.1	0.2	0.2	0.2	0.5	-0.5
Distance traveled after self-admin	0.1	0.2	0.4	0.0	0.2	-0.7
Extensor digitorum longus weight	11.2	44.0	47.8	-6.9	-6.7	6.3
Bone: elastic displacement	0.2	0.2	0.7	-0.1	-0.2	0.8
Bone: elastic work	0.1	0.2	0.5	0.2	-0.0	0.7
Bone: endosteal estimation	0.3	0.6	1.0	1.0	1.0	0.2
Bone: endosteal perimeter	0.4	0.8	1.1	1.1	1.0	-0.5
Epididymis fat weight	0.1	0.2	0.5	0.1	0.1	-0.7
Delta time in closed arm before/after self-admin	0.3	0.3	0.4	0.5	0.4	-0.6
Delta time in open arm before/after self-admin	0.0	0.0	0.0	-0.1	0.1	-0.1
Diff in mean of infusions in LGA sessions	2.5	2.8	3.6	-1.6	-1.5	1.9
Delay discount exponential model param	0.7	0.7	0.9	0.9	0.9	-0.6
Extinction: sum of active levers before priming	1.1	1.0	1.2	-1.0	-1.1	0.9
Active lever presses in extinction session 6	0.4	0.4	0.4	0.7	0.7	-0.5
Bone: final force	0.2	0.3	0.8	-0.1	-0.2	0.9
Bone: final moment	0.1	0.1	0.2	0.2	0.2	0.5
Food consumed during 24 hour testing period	2.3	2.7	2.9	-1.7	-1.6	1.6
Glucose	1.7	2.5	2.6	-1.6	-1.6	1.5
Heart weight	1.9	2.6	3.1	1.6	1.5	-1.8
Delay discount hyperbolic model param	1.0	1.1	1.3	1.1	1.1	-0.8
Intermittent access intake day 1-15 change	6.2	6.1	6.3	2.4	2.5	-2.5
Intermittent access intake escalation	4.6	4.5	4.7	2.1	2.1	-2.2
Intermittent access intake escalation 2	5.8	5.7	6.3	2.5	2.3	-2.3
Intermitt. access day 1 inactive lever presses	0.5	0.6	1.1	-1.1	-0.8	0.2
Intermitt. access day 15 inactive lever presses	0.2	0.2	0.5	-0.1	-0.2	-0.7
Intermitt. access escalation Index	0.1	0.1	0.1	-0.3	-0.2	-0.1
Intermittent access day 1 total infusions	1.4	1.6	2.5	1.6	1.3	-0.9
Intermittent access day 15 total infusions	7.5	8.4	10.4	3.2	2.9	-2.5
Intermittent access terminal intake (last 3 days)	6.9	7.5	10.0	3.2	2.6	-2.4
Intermittent access total infusions	4.6	5.2	6.7	2.6	2.3	-1.9
Intermittent access day 1 locomotion	0.3	0.3	0.5	0.7	0.5	-0.4
Intermittent access day 15 total locomotion	0.7	0.8	1.1	1.1	1.0	-0.4
Intermittent access total locomotion	0.9	1.1	1.6	1.2	1.0	-0.8
Intermittent access standard deviation	6.0	6.4	7.6	2.4	2.4	-2.8
Left kidney weight	1.1	3.1	4.1	1.8	1.4	-2.0
Right kidney weight	0.6	1.6	2.9	1.1	0.8	-1.7
Cocaine induced anxiety	0.1	0.2	0.4	-0.4	-0.6	0.0
Post-drug Anxiety	1.8	2.0	2.5	-1.6	-1.5	1.2
Baseline Anxiety	0.1	0.2	0.3	-0.4	-0.1	0.5
Tail length	0.5	1.7	2.1	-1.3	-1.4	1.1
Length with tail	0.0	0.0	0.0	-0.0	-0.2	-0.0
Length without tail	0.6	1.3	1.5	1.2	1.2	-0.9
Times rat made contact with spout	0.1	0.1	0.2	0.4	0.1	-0.2
Lifetime Intake	4.6	5.2	6.5	2.5	2.3	-2.0
Liver weight, left	1.9	3.1	3.5	-1.6	-1.8	1.9
Liver weight, right	0.2	0.3	0.6	-0.5	-0.8	0.3
Locomotor activity	0.0	0.0	0.0	-0.1	0.1	-0.0
Locomotor testing distance	0.0	0.0	0.0	-0.0	0.0	0.1
Locomotor testing rearing	0.8	1.2	1.3	1.1	1.0	-1.1
Locomotion in novel chamber	0.9	1.1	1.4	-1.0	-0.9	1.2
Locomotion in novel chamber post-restriction	0.0	0.0	0.1	0.1	0.1	-0.2
Fecal boli incidents, locomotor time 1	0.3	0.4	0.5	-0.7	-0.6	0.5
Change in fecal boli incidents, locomotor task	3.0	2.8	3.7	1.6	1.9	-1.4
Time >=10cm from walls, locomotor time 1	1.2	1.2	1.8	1.1	1.4	-0.6
Bouts of movement, locomotor time 1	0.5	0.6	1.6	0.2	0.3	-1.3
Total resting periods, locomotor time 1	0.5	0.5	1.3	0.3	0.4	-1.1
Rest time, locomotor task time 1	0.6	0.6	1.2	0.5	0.7	-1.1
Distance moved, locomotor task time 1	0.0	0.0	0.0	0.2	-0.2	0.1
Vertical activity count, locomotor time 1	0.1	0.2	0.4	-0.0	-0.1	0.7
Time >=10cm from walls, locomotor time 2	0.5	0.5	0.9	0.7	1.0	0.0
Bouts of movement, locomotor time 2	0.2	0.2	0.3	-0.5	-0.5	-0.5
Total resting periods, locomotor time 2	0.2	0.3	0.3	-0.5	-0.5	-0.6
Rest time, locomotor task time 2	0.1	0.1	0.1	-0.3	-0.3	-0.1
Distance moved, locomotor task time 2	0.0	0.0	0.1	0.3	0.0	-0.2
Vertical activity count, locomotor time 2	1.2	1.3	1.6	-1.1	-1.0	1.3
Light reinforcement 1	0.8	1.5	2.4	-1.2	-1.6	0.7
Light reinforcement 2	2.7	3.7	4.3	-2.0	-2.1	1.7
Bone: marrow area	0.2	0.5	0.7	0.8	0.9	0.3
Bone: maximum diameter	0.1	0.3	0.4	0.7	0.6	-0.2
Bone: maximum force	0.1	0.2	0.7	0.1	-0.1	0.8
Bone: maximum moment	0.1	0.2	0.2	0.5	0.4	0.4
Mean time between licks in bursts	1.3	1.9	2.6	-1.3	-1.1	1.6
Mean num. licks in bursts	0.1	0.1	0.2	-0.4	-0.4	0.2
Cd content in liver	0.8	0.9	1.5	-1.2	-1.1	0.2
Co content in liver	0.1	0.1	0.2	-0.4	-0.3	-0.3
Cu content in liver	4.4	5.3	5.8	2.4	2.2	-2.3
Fe content in liver	0.2	0.3	0.3	0.5	0.4	0.6
K content in liver	0.8	0.8	1.1	0.7	0.8	-1.1
Mg content in liver	0.5	0.5	0.6	0.7	0.7	-0.7
Mn content in liver	0.3	0.3	0.5	-0.7	-0.7	0.3
Na content in liver	1.2	1.2	1.3	1.1	1.1	-1.1
Rb content in liver	0.0	0.0	0.0	-0.0	-0.2	-0.1
Se content in liver	0.2	0.2	0.4	0.4	0.4	-0.6
Sr content in liver	0.7	0.6	1.1	-1.1	-0.7	0.6
Zn content in liver	1.8	1.9	2.3	1.3	1.4	-1.5
Bone: minimum diameter	0.9	1.6	4.1	-0.5	-0.6	2.0
Time in familiar zone, hab. session 1	1.0	0.9	1.6	0.7	0.8	-1.3
Time in novel zone, hab. session 1	0.1	0.1	0.2	-0.2	-0.3	0.4
Total zone transitions, hab. session 1	1.2	1.6	2.1	-1.2	-1.2	1.4
Total locomotion distance, hab. session 1	0.4	0.6	1.3	-0.5	-0.6	1.1
Locomotion velocity, hab. session 1	0.9	1.3	2.3	-0.8	-1.0	1.5
Time in familiar zone, hab. session 2	2.5	2.6	4.2	1.2	1.4	-2.1
Time in novel zone, hab. session 2	0.9	0.9	1.8	-0.6	-0.8	1.3
Total zone transitions, hab. session 2	0.3	0.4	0.6	-0.8	-0.6	0.3
Total locomotion distance, hab. session 2	0.2	0.3	0.4	-0.4	-0.5	0.6
Locomotion velocity, hab. session 2	0.1	0.2	0.3	-0.3	-0.4	0.5
Novel to familiar place preference ratio	0.1	0.1	0.2	-0.3	-0.2	0.4
Novelty place preference	0.0	0.0	0.0	-0.1	-0.0	0.2
Time in novel zone, NPP test	0.0	0.0	0.0	-0.2	-0.1	0.1
Total zone transitions, NPP test	0.7	1.1	1.3	-1.2	-1.1	0.8
Total locomotion distance, NPP test	0.5	0.7	1.0	-0.6	-0.8	1.0
Locomotion velocity, NPP test	0.2	0.3	0.6	-0.3	-0.5	0.8
Intraocular pressure	2.6	3.6	4.1	-1.9	-1.7	2.0
Delta distance traveled before/after self-admin	0.3	0.4	0.5	0.7	0.5	-0.6
Delta ambulatory time before/after self-admin	0.8	0.9	1.1	1.0	0.8	-1.0
Parametrial fat weight	0.1	0.2	0.4	-0.6	-0.4	0.3
Pavlov. Cond. lever latency	0.8	1.0	1.2	0.9	0.9	-1.1
Pavlov. Cond. magazine entry latency	0.4	0.6	0.8	-0.6	-0.7	0.9
Pavlov. Cond. change in total contacts	3.2	3.4	3.9	-1.7	-1.8	2.0
Pavlov. Cond. index score	1.0	1.2	1.3	-1.1	-1.1	1.1
Pavlov. Cond. latency score	0.9	1.1	1.2	-1.0	-1.1	1.1
Pavlov. Cond. lever contacts	1.0	1.2	1.7	-1.0	-1.0	1.3
Pavlov. Cond. magazine entry number	0.9	1.1	1.2	1.0	1.1	-1.0
Pavlov. Cond. intertrial magazine entries	0.5	0.6	0.7	0.8	0.8	-0.6
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.2	1.2	-1.0	-1.1	1.1
Pavlov. Cond. response bias	1.0	1.2	1.6	-1.0	-1.0	1.2
Pavlov. Cond. lever latency	1.2	1.6	1.9	-1.4	-1.3	1.1
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	0.1	-0.1	0.1
Pavlov. Cond. change in total contacts	0.1	0.2	0.4	0.3	0.2	0.7
Pavlov. Cond. index score	0.1	0.1	0.3	0.5	0.3	0.2
Pavlov. Cond. latency score	0.2	0.2	0.5	0.7	0.5	-0.1
Pavlov. Cond. lever contacts	0.7	0.9	1.2	1.1	1.0	-0.7
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	-0.0	0.3	-0.4
Pavlov. Cond. intertrial magazine entries	0.3	0.3	0.5	-0.6	-0.4	0.7
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.4	0.6	0.4	0.0
Pavlov. Cond. response bias	0.2	0.3	0.6	0.8	0.6	-0.1
Time in closed arm before self-admin	0.5	0.5	0.7	0.8	0.5	-0.8
Time in closed arm after self-admin	0.7	0.7	1.2	0.8	0.5	-1.1
Time in open arm before self-admin	0.1	0.1	0.3	0.1	0.0	0.6
Time in open arm after self-admin	1.4	1.5	1.6	-1.3	-1.1	1.2
Bone: periosteal estimation	0.2	0.4	0.9	0.5	0.4	0.9
Bone: periosteal perimeter	0.2	0.4	0.6	0.8	0.7	-0.1
Bone: post-yield work	3.3	4.5	5.7	2.4	2.1	-1.9
Progressive ratio test 1 active lever presses	3.6	3.7	4.4	1.9	1.7	-2.1
Progressive ratio test 1 breakpoint	3.4	3.5	3.8	1.9	1.7	-1.9
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.2	0.1	0.2	-0.5
Progressive ratio test 2 active lever presses	3.4	3.7	4.6	2.2	2.0	-1.6
Progressive ratio test 2 breakpoint	3.1	3.5	4.4	2.1	2.0	-1.5
Progressive ratio test 2 inactive lever presses	1.9	2.2	2.6	1.6	1.5	-1.3
Incentive Sensitization - Responses	1.4	1.4	2.3	1.5	1.2	-0.6
Incentive Sensitization - Breakpoint	1.5	1.5	2.4	1.6	1.2	-0.7
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	0.5	0.4	0.1
Progressive ratio	1.1	1.3	2.3	1.0	0.7	-1.5
Food seeking constrained by brief footshock	3.5	4.3	5.8	-2.0	-1.8	2.4
Seeking ratio, punishment vs. effort	3.9	4.8	7.3	-2.1	-1.6	2.7
Retroperitoneal fat weight	0.1	0.2	0.4	0.2	0.6	-0.4
Reaction time number correct	0.2	0.3	0.5	0.7	0.7	0.1
Reaction time mean minus median	2.4	3.2	4.4	-2.1	-1.9	1.3
Reaction time mean minus median AUC	3.4	4.4	5.3	-2.3	-2.2	1.7
Reaction time num false alarms	0.4	0.6	1.0	1.0	0.9	-0.2
Reaction time num false alarms AUC	0.5	0.6	1.0	1.0	0.9	-0.3
Reaction time trials correct on left	0.2	0.3	0.5	0.7	0.7	0.1
Reaction time trials on left	0.2	0.3	0.4	0.6	0.6	0.2
Reaction time mean	2.1	2.9	3.4	-1.8	-1.6	1.7
Reaction time mean AUC	2.4	3.2	3.5	-1.9	-1.7	1.8
Median of all reaction times	1.8	2.5	3.0	-1.6	-1.4	1.7
Reaction time omissions	4.4	6.1	6.9	-2.6	-2.6	2.1
Reaction time false alarm rate	0.1	0.1	0.1	0.4	0.2	-0.3
Reaction time premature initiation rate	2.1	2.8	3.5	1.6	1.5	-1.9
Reaction time premature initiations	2.1	3.0	3.1	1.8	1.8	-1.6
Std. dev. reaction times	1.5	2.2	2.8	-1.7	-1.6	1.1
Reaction time trials completed	0.2	0.3	0.4	0.6	0.6	0.2
Reaction time trials AUC	0.1	0.2	0.3	0.5	0.5	0.3
Run reversals in cocaine runway, females	0.6	0.6	0.9	-1.0	-0.5	0.7
Run reversals in cocaine runway, males	3.6	3.5	3.8	-1.8	-1.8	2.0
Latency to leave start box in cocaine runway	0.7	0.8	0.8	0.9	0.9	-0.8
Latency to leave start box in cocaine runway, F	3.1	3.4	3.6	1.9	1.8	-1.8
Latency to leave start box in cocaine runway, M	2.2	2.1	2.4	-1.6	-1.3	1.5
Std. dev. time between licks in bursts	0.0	0.1	0.1	-0.1	0.2	0.3
Total sessions with >9 infusions	1.2	1.3	1.6	1.2	1.0	-1.3
Short access day 1 total inactive lever presses	0.5	0.6	0.8	0.7	0.6	-0.9
Short access day 10 total inactive lever presses	0.1	0.1	0.3	-0.5	0.1	-0.3
Short access day 1 total infusions	3.0	3.2	3.5	1.9	1.7	-1.7
Short access day 10 total infusions	2.9	3.2	3.6	1.9	1.6	-1.8
Short access total infusions	3.3	3.7	4.3	2.1	1.9	-1.8
Short access day 1 locomotion	0.2	0.3	0.4	0.5	0.3	-0.6
Short access day 10 total locomotion	0.8	0.9	1.2	-1.1	-1.1	0.7
Short access total locomotion	0.4	0.4	0.7	0.8	0.5	-0.6
One hour access (0.3 mA shock)	5.7	6.6	7.9	2.8	2.8	-2.1
Compulsive drug intake	1.1	1.1	1.8	-1.3	-0.8	1.0
One hour access (shock baseline)	8.2	9.5	11.8	3.4	3.1	-2.7
Social response proportion	0.1	0.1	0.3	-0.5	-0.3	0.2
Social responses	0.4	0.5	0.7	-0.8	-0.8	0.5
Social time	0.0	0.0	0.0	0.2	0.0	0.1
Soleus weight	0.9	2.6	3.0	-1.5	-1.7	1.6
Bone: stiffness	0.1	0.1	0.2	-0.2	-0.1	0.5
Tibialis anterior weight	9.2	31.6	32.8	-5.7	-5.5	5.6
Time to tail flick, vehicle, before self-admin	0.9	1.0	1.3	1.1	1.1	-0.6
Time to tail flick, vehicle, after self-admin	2.5	2.7	3.4	1.7	1.9	-1.3
Time to tail flick, test, before self-admin	0.1	0.1	0.3	-0.1	-0.2	-0.6
Time to tail flick, test, after self-admin	0.7	0.8	1.0	0.9	0.7	-1.0
Delta time to tail flick, vehicle, before/after SA	1.2	1.2	1.8	1.0	1.3	-0.9
Delta time to tail flick, test, before/after SA	0.0	0.0	0.1	0.2	0.1	-0.3
Tibia length	1.4	4.1	4.2	2.0	2.0	-2.0
Ambulatory time before self-admin	0.1	0.1	0.2	0.0	0.5	-0.4
Ambulatory time after self-admin	0.3	0.3	0.6	0.4	0.5	-0.8
Bone: tissue strength	2.6	2.5	2.7	1.6	1.5	-1.6
Total heroin consumption	0.2	0.2	0.4	-0.4	-0.2	0.6
Bone: trabecular number	0.7	1.1	1.4	1.2	1.2	-0.8
Bone: trabecular spacing	1.1	1.5	2.0	-1.4	-1.3	0.8
Bone: trabecular thickness	1.6	2.0	2.8	1.7	1.6	-0.8
Bone: trabecular tissue density	2.2	3.1	4.0	-1.8	-2.0	1.3
Water consumed over 24 hours	0.1	0.1	0.2	-0.4	-0.4	0.4
Number of responses in last shaping day	0.1	0.1	0.2	0.4	0.3	-0.3