Pavlov. Cond. index score

Pavlovian Conditioned Approach, Sign/goal-tracking, average of LatencyScore, ProbDiff, and ResponseBias on days 4 and 5 of testing

Tags: Behavior · Pavlovian conditioned approach · Conditioned reinforcement

Project: p50_paul_meyer_2014

2 loci · 2 genes with independent associations · 2 total associated genes

Significant Loci

# Chr Start pos End pos # assoc genes # joint models Best TWAS P Best GWAS P Cond GWAS P Joint genes
1 chr1 149199615 150594931 1 1 2.26e-07 1.49e-07 1.42e-01 Tenm4
2 chr1 152785136 154174144 1 1 1.29e-07 9.70e-07 5.99e-01 Dgat2

Pleiotropic Associations

Trait Chi2 ratio # genes+ # genes++ % genes++ Corr Corr P Genes
Liver weight, right 4.97 1 0 0 0 1e+00 Tenm4
Retroperitoneal fat weight 4.35 1 0 0 0 1e+00 Dgat2
Intraocular pressure 5.43 1 0 0 0 1e+00 Tenm4
Tibia length 1.92 1 0 0 0 1e+00 Dgat2
Number of licking bursts 5.69 1 0 0 0 1e+00 Dgat2
Mean num. licks in bursts 4.21 1 0 0 0 1e+00 Dgat2
Patch foraging indifference point 0 sec 7.33 1 0 0 0 1e+00 Dgat2
Patch foraging total patch changes 0 sec 6.17 1 0 0 0 1e+00 Dgat2
Patch foraging time to switch 0 sec 4.75 2 0 0 0 1e+00 Dgat2 Tenm4
Patch foraging water rate 0 sec 4.09 1 0 0 0 1e+00 Dgat2
Patch foraging water rate 12 sec 4.45 1 0 0 0 1e+00 Tenm4
Condit. Reinf. active minus inactive responses 5.84 2 0 0 0 1e+00 Dgat2 Tenm4
Condit. Reinf. active responses 7.31 2 0 0 0 1e+00 Dgat2 Tenm4
Condit. Reinf. inactive responses 5.25 1 0 0 0 1e+00 Dgat2
Condit. Reinf. lever presses 21.29 2 1 50 0 1e+00 Dgat2 Tenm4
Condit. Reinf. lever reinforcers received 8.36 2 0 0 0 1e+00 Dgat2 Tenm4
Pavlov. Cond. lever latency 26.63 2 2 100 0 1e+00 Dgat2 Tenm4
Pavlov. Cond. magazine entry latency 9.24 2 0 0 0 1e+00 Dgat2 Tenm4
Pavlov. Cond. change in total contacts 16.22 2 0 0 0 1e+00 Dgat2 Tenm4
Pavlov. Cond. latency score 19.22 2 0 0 0 1e+00 Dgat2 Tenm4
Pavlov. Cond. lever contacts 26.62 2 2 100 0 1e+00 Dgat2 Tenm4
Pavlov. Cond. magazine entry number 14.76 2 0 0 0 1e+00 Dgat2 Tenm4
Pavlov. Cond. lever-magazine prob. diff. 19.81 2 0 0 0 1e+00 Dgat2 Tenm4
Pavlov. Cond. response bias 27.51 2 2 100 0 1e+00 Dgat2 Tenm4
Locomotion velocity, session 8 5.78 1 0 0 0 1e+00 Tenm4
Degree of sensitization stereotypy 5.43 1 0 0 0 1e+00 Dgat2
Total locomotion distance, hab. session 1 5.67 1 0 0 0 1e+00 Tenm4
Locomotion velocity, hab. session 1 6.07 1 0 0 0 1e+00 Tenm4
Total locomotion distance, NPP test 4.82 1 0 0 0 1e+00 Tenm4
Locomotion velocity, NPP test 6.21 1 0 0 0 1e+00 Tenm4
Delta time in closed arm before/after self-admin 6.07 1 0 0 0 1e+00 Tenm4
Time to tail flick, vehicle, after self-admin 5.36 1 0 0 0 1e+00 Tenm4
Locomotion in novel chamber post-restriction 4.34 1 0 0 0 1e+00 Dgat2
Run reversals in cocaine runway, males 5.53 1 0 0 0 1e+00 Tenm4
Latency to leave start box in cocaine runway 5.94 1 0 0 0 1e+00 Tenm4
Latency to leave start box in cocaine runway, F 5.18 1 0 0 0 1e+00 Tenm4
Se content in liver 5.01 1 0 0 0 1e+00 Dgat2
Zn content in liver 6.03 1 0 0 0 1e+00 Dgat2

Associations by panel

Tissue RNA modality # hits % hits/tests Avg chisq
Adipose alternative polyA 0 0 1.29
Adipose alternative TSS 0 0 1.35
Adipose gene expression 0 0 1.28
Adipose isoform ratio 0 0 1.29
Adipose intron excision ratio 0 0 1.12
Adipose mRNA stability 0 0 1.31
BLA alternative polyA 0 0 1.34
BLA alternative TSS 0 0 1.29
BLA gene expression 0 0 1.3
BLA isoform ratio 0 0 1.33
BLA intron excision ratio 0 0 1.25
BLA mRNA stability 0 0 1.31
Brain alternative polyA 0 0 1.3
Brain alternative TSS 0 0 1.27
Brain gene expression 0 0 1.28
Brain isoform ratio 0 0 1.3
Brain intron excision ratio 0 0 1.24
Brain mRNA stability 0 0 1.27
Eye alternative polyA 0 0 1.43
Eye alternative TSS 0 0 1.27
Eye gene expression 0 0 1.37
Eye isoform ratio 0 0 1.25
Eye intron excision ratio 0 0 1.29
Eye mRNA stability 0 0 1.38
IL alternative polyA 0 0 1.25
IL alternative TSS 0 0 1.1
IL gene expression 0 0 1.3
IL isoform ratio 0 0 1.31
IL intron excision ratio 0 0 1.24
IL mRNA stability 0 0 1.29
LHb alternative polyA 0 0 1.36
LHb alternative TSS 0 0 1.43
LHb gene expression 0 0 1.27
LHb isoform ratio 0 0 1.3
LHb intron excision ratio 0 0 1.22
LHb mRNA stability 0 0 1.26
Liver alternative polyA 0 0 1.25
Liver alternative TSS 0 0 1.28
Liver gene expression 1 0 1.32
Liver isoform ratio 0 0 1.29
Liver intron excision ratio 0 0 1.3
Liver mRNA stability 0 0 1.32
NAcc alternative polyA 0 0 1.36
NAcc alternative TSS 0 0 1.26
NAcc gene expression 1 0 1.28
NAcc isoform ratio 0 0 1.3
NAcc intron excision ratio 0 0 1.22
NAcc mRNA stability 0 0 1.28
OFC alternative polyA 0 0 1.38
OFC alternative TSS 0 0 1.26
OFC gene expression 0 0 1.27
OFC isoform ratio 0 0 1.34
OFC intron excision ratio 0 0 1.23
OFC mRNA stability 0 0 1.29
PL alternative polyA 0 0 1.43
PL alternative TSS 0 0 1.33
PL gene expression 0 0 1.29
PL isoform ratio 0 0 1.28
PL intron excision ratio 0 0 1.23
PL mRNA stability 0 0 1.29
pVTA alternative polyA 0 0 1.37
pVTA alternative TSS 0 0 1.29
pVTA gene expression 0 0 1.3
pVTA isoform ratio 0 0 1.27
pVTA intron excision ratio 0 0 1.21
pVTA mRNA stability 0 0 1.29
RMTg alternative polyA 0 0 1.15
RMTg alternative TSS 0 0 1.14
RMTg gene expression 0 0 1.31
RMTg isoform ratio 0 0 1.11
RMTg intron excision ratio 0 0 1.23
RMTg mRNA stability 0 0 1.28