Hub : Traits

Pavlov. Cond. index score

Pavlovian Conditioned Approach, Sign/goal-tracking, average of LatencyScore, ProbDiff, and ResponseBias on days 4 and 5 of testing

Tags: Behavior · Pavlovian conditioned approach · Conditioned reinforcement

Project: p50_paul_meyer_2014

2 loci · 2 genes with independent associations · 2 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr1	149199615	150594931	1	1	2.26e-07	1.49e-07	1.42e-01	Tenm4
2	chr1	152785136	154174144	1	1	1.29e-07	9.70e-07	5.99e-01	Dgat2

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
Liver weight, right	4.97	1	0	0	0	1e+00	Tenm4
Retroperitoneal fat weight	4.35	1	0	0	0	1e+00	Dgat2
Intraocular pressure	5.43	1	0	0	0	1e+00	Tenm4
Tibia length	1.92	1	0	0	0	1e+00	Dgat2
Number of licking bursts	5.69	1	0	0	0	1e+00	Dgat2
Mean num. licks in bursts	4.21	1	0	0	0	1e+00	Dgat2
Patch foraging indifference point 0 sec	7.33	1	0	0	0	1e+00	Dgat2
Patch foraging total patch changes 0 sec	6.17	1	0	0	0	1e+00	Dgat2
Patch foraging time to switch 0 sec	4.75	2	0	0	0	1e+00	Dgat2 Tenm4
Patch foraging water rate 0 sec	4.09	1	0	0	0	1e+00	Dgat2
Patch foraging water rate 12 sec	4.45	1	0	0	0	1e+00	Tenm4
Condit. Reinf. active minus inactive responses	5.84	2	0	0	0	1e+00	Dgat2 Tenm4
Condit. Reinf. active responses	7.31	2	0	0	0	1e+00	Dgat2 Tenm4
Condit. Reinf. inactive responses	5.25	1	0	0	0	1e+00	Dgat2
Condit. Reinf. lever presses	21.29	2	1	50	0	1e+00	Dgat2 Tenm4
Condit. Reinf. lever reinforcers received	8.36	2	0	0	0	1e+00	Dgat2 Tenm4
Pavlov. Cond. lever latency	26.63	2	2	100	0	1e+00	Dgat2 Tenm4
Pavlov. Cond. magazine entry latency	9.24	2	0	0	0	1e+00	Dgat2 Tenm4
Pavlov. Cond. change in total contacts	16.22	2	0	0	0	1e+00	Dgat2 Tenm4
Pavlov. Cond. latency score	19.22	2	0	0	0	1e+00	Dgat2 Tenm4
Pavlov. Cond. lever contacts	26.62	2	2	100	0	1e+00	Dgat2 Tenm4
Pavlov. Cond. magazine entry number	14.76	2	0	0	0	1e+00	Dgat2 Tenm4
Pavlov. Cond. lever-magazine prob. diff.	19.81	2	0	0	0	1e+00	Dgat2 Tenm4
Pavlov. Cond. response bias	27.51	2	2	100	0	1e+00	Dgat2 Tenm4
Locomotion velocity, session 8	5.78	1	0	0	0	1e+00	Tenm4
Degree of sensitization stereotypy	5.43	1	0	0	0	1e+00	Dgat2
Total locomotion distance, hab. session 1	5.67	1	0	0	0	1e+00	Tenm4
Locomotion velocity, hab. session 1	6.07	1	0	0	0	1e+00	Tenm4
Total locomotion distance, NPP test	4.82	1	0	0	0	1e+00	Tenm4
Locomotion velocity, NPP test	6.21	1	0	0	0	1e+00	Tenm4
Delta time in closed arm before/after self-admin	6.07	1	0	0	0	1e+00	Tenm4
Time to tail flick, vehicle, after self-admin	5.36	1	0	0	0	1e+00	Tenm4
Locomotion in novel chamber post-restriction	4.34	1	0	0	0	1e+00	Dgat2
Run reversals in cocaine runway, males	5.53	1	0	0	0	1e+00	Tenm4
Latency to leave start box in cocaine runway	5.94	1	0	0	0	1e+00	Tenm4
Latency to leave start box in cocaine runway, F	5.18	1	0	0	0	1e+00	Tenm4
Se content in liver	5.01	1	0	0	0	1e+00	Dgat2
Zn content in liver	6.03	1	0	0	0	1e+00	Dgat2

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	0	0	1.29
Adipose	alternative TSS	0	0	1.35
Adipose	gene expression	0	0	1.28
Adipose	isoform ratio	0	0	1.29
Adipose	intron excision ratio	0	0	1.12
Adipose	mRNA stability	0	0	1.31
BLA	alternative polyA	0	0	1.34
BLA	alternative TSS	0	0	1.29
BLA	gene expression	0	0	1.3
BLA	isoform ratio	0	0	1.33
BLA	intron excision ratio	0	0	1.25
BLA	mRNA stability	0	0	1.31
Brain	alternative polyA	0	0	1.3
Brain	alternative TSS	0	0	1.27
Brain	gene expression	0	0	1.28
Brain	isoform ratio	0	0	1.3
Brain	intron excision ratio	0	0	1.24
Brain	mRNA stability	0	0	1.27
Eye	alternative polyA	0	0	1.43
Eye	alternative TSS	0	0	1.27
Eye	gene expression	0	0	1.37
Eye	isoform ratio	0	0	1.25
Eye	intron excision ratio	0	0	1.29
Eye	mRNA stability	0	0	1.38
IL	alternative polyA	0	0	1.25
IL	alternative TSS	0	0	1.1
IL	gene expression	0	0	1.3
IL	isoform ratio	0	0	1.31
IL	intron excision ratio	0	0	1.24
IL	mRNA stability	0	0	1.29
LHb	alternative polyA	0	0	1.36
LHb	alternative TSS	0	0	1.43
LHb	gene expression	0	0	1.27
LHb	isoform ratio	0	0	1.3
LHb	intron excision ratio	0	0	1.22
LHb	mRNA stability	0	0	1.26
Liver	alternative polyA	0	0	1.25
Liver	alternative TSS	0	0	1.28
Liver	gene expression	1	0	1.32
Liver	isoform ratio	0	0	1.29
Liver	intron excision ratio	0	0	1.3
Liver	mRNA stability	0	0	1.32
NAcc	alternative polyA	0	0	1.36
NAcc	alternative TSS	0	0	1.26
NAcc	gene expression	1	0	1.28
NAcc	isoform ratio	0	0	1.3
NAcc	intron excision ratio	0	0	1.22
NAcc	mRNA stability	0	0	1.28
OFC	alternative polyA	0	0	1.38
OFC	alternative TSS	0	0	1.26
OFC	gene expression	0	0	1.27
OFC	isoform ratio	0	0	1.34
OFC	intron excision ratio	0	0	1.23
OFC	mRNA stability	0	0	1.29
PL	alternative polyA	0	0	1.43
PL	alternative TSS	0	0	1.33
PL	gene expression	0	0	1.29
PL	isoform ratio	0	0	1.28
PL	intron excision ratio	0	0	1.23
PL	mRNA stability	0	0	1.29
pVTA	alternative polyA	0	0	1.37
pVTA	alternative TSS	0	0	1.29
pVTA	gene expression	0	0	1.3
pVTA	isoform ratio	0	0	1.27
pVTA	intron excision ratio	0	0	1.21
pVTA	mRNA stability	0	0	1.29
RMTg	alternative polyA	0	0	1.15
RMTg	alternative TSS	0	0	1.14
RMTg	gene expression	0	0	1.31
RMTg	isoform ratio	0	0	1.11
RMTg	intron excision ratio	0	0	1.23
RMTg	mRNA stability	0	0	1.28