Fermt3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	LHb	alternative TSS	NM_001127543.1	0.19	0.11	1.5e-03	0.07	0.09	0.1	0.08	1.1e-02	4.4e-03	3.0e-03	7.4e-03
2	LHb	alternative TSS	NM_001127543.1	0.19	0.11	1.0e-03	0.09	0.11	0.11	0.1	4.4e-03	1.4e-03	1.5e-03	2.7e-03
3	LHb	alternative TSS	XM_006230811.5	0.18	0.11	2.0e-03	0.05	0.09	0.09	0.07	2.8e-02	3.5e-03	3.6e-03	8.6e-03
4	BLA	intron excision ratio	chr1_213636273_213636704	0.1	0.06	9.0e-04	0.01	0.03	0.03	0.02	6.9e-02	8.1e-03	1.5e-02	4.0e-02
5	BLA	intron excision ratio	chr1_213636270_213636704	0.1	0.06	9.4e-04	0.01	0.03	0.03	0.02	7.0e-02	8.3e-03	1.5e-02	4.3e-02
6	Liver	gene expression	Fermt3	0.03	0.02	3.7e-03	0.01	0.01	0.01	0.01	1.3e-02	9.0e-03	2.9e-02	9.2e-03
7	LHb	alternative TSS	XM_006230811.5	0.19	0.11	1.3e-03	0.07	0.12	0.12	0.11	1.1e-02	1.1e-03	1.0e-03	1.5e-03
8	RMTg	alternative polyA	XM_039079706.2	0.13	0.08	9.5e-03	-0.01	0	-0.01	-0.01	5.0e-01	3.2e-01	7.2e-01	6.4e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8
Bone: apparent density	0.2	0.3	0.8	0.5	0.4	-0.4	0.1	-0.1	0.9	0.4	-0.9
Area under the delay curve	0.1	0.2	0.6	-0.0	-0.0	0.0	-0.3	0.3	0.3	0.7	-0.8
BMI with tail	0.8	2.8	9.0	1.1	1.3	-1.2	0.3	-0.3	2.6	1.5	-3.0
BMI without tail	0.6	1.7	5.6	1.2	1.1	-1.1	0.5	-0.5	1.8	0.2	-2.4
Body weight	1.8	7.7	14.9	2.8	2.9	-2.7	2.0	-1.9	3.9	-0.5	-3.9
Weight adjusted by age	1.2	1.8	2.3	1.4	1.5	-1.4	1.5	-1.5	1.5	-0.9	-0.8
Bone surface	2.4	4.4	7.8	2.3	2.4	-2.2	2.0	-1.9	2.8	-0.9	-1.8
Bone volume	0.5	0.9	2.2	1.0	1.1	-1.0	0.8	-0.8	1.5	0.0	-0.7
Breakpoint value in progressive ratio session	3.4	4.0	5.0	2.1	2.2	-2.2	2.2	-2.1	2.1	-1.7	-1.3
Number of licking bursts	0.2	0.3	0.3	0.5	0.6	-0.5	0.6	-0.6	0.5	-0.5	-0.2
Context. condit. distance diff. score	1.5	1.8	2.4	-1.4	-1.5	1.4	-1.6	1.6	-1.2	1.3	0.5
Locomotion velocity, session 1	0.1	0.1	0.7	0.1	-0.1	0.0	-0.3	0.4	0.2	0.1	-0.8
Locomotion distance, session 1	0.3	0.3	1.6	0.4	0.1	-0.1	-0.3	0.3	0.7	0.4	-1.3
Locomotion velocity, session 2	1.7	2.0	3.2	1.6	1.5	-1.5	1.2	-1.2	1.8	-0.7	-1.7
Locomotion distance, session 2	0.3	0.5	1.7	0.7	0.5	-0.6	0.2	-0.2	0.9	-0.1	-1.3
Locomotion velocity, session 3	2.0	2.2	5.2	-1.2	-1.3	1.4	-1.8	1.9	-0.5	2.3	-0.5
Locomotion distance, session 3	0.1	0.1	0.3	-0.3	-0.3	0.3	-0.5	0.5	-0.1	0.6	-0.3
Stereotopy head waving bouts, day 3	2.2	2.6	5.3	-1.4	-1.5	1.5	-2.0	2.0	-0.8	2.3	-0.3
Stereotopy head waving duration, day 3	1.4	1.6	2.5	-1.3	-1.3	1.3	-1.5	1.5	-1.0	1.6	0.4
Locomotion velocity, session 7	1.4	1.5	2.9	-1.2	-1.2	1.2	-1.5	1.5	-0.7	1.7	0.2
Locomotion distance, session 7	0.3	0.4	0.8	-0.4	-0.5	0.5	-0.8	0.8	-0.1	0.9	-0.7
Stereotopy head waving bouts, day 7	0.1	0.1	0.3	-0.4	-0.3	0.3	-0.3	0.3	-0.2	0.6	0.4
Stereotopy head waving duration, day 7	0.4	0.4	0.7	0.6	0.8	-0.7	0.8	-0.8	0.8	-0.3	-0.2
Locomotion velocity, session 8	1.0	1.2	2.4	1.3	1.1	-1.1	0.8	-0.8	1.3	-0.9	-1.6
Locomotion distance, session 8	0.6	0.9	1.7	-0.8	-0.9	0.9	-1.3	1.3	-0.4	1.2	-0.3
Degree of sensitization distance	0.4	0.4	1.0	-0.4	-0.5	0.5	-0.8	0.8	-0.0	1.0	-0.5
Degree of sensitization stereotypy	0.2	0.2	0.3	0.4	0.5	-0.4	0.5	-0.5	0.5	-0.2	0.1
Conditioned locomotion	1.2	1.4	1.8	1.3	1.2	-1.2	1.1	-1.0	1.4	-0.9	-1.3
Cocaine response after cond. corrected	1.4	1.7	2.6	-1.3	-1.4	1.4	-1.6	1.6	-1.1	1.4	0.1
Cocaine response after cond. not corrected	1.0	1.2	1.8	-1.1	-1.2	1.1	-1.3	1.3	-0.9	1.2	0.0
Cocaine response before conditioning	0.8	1.0	1.5	1.0	1.1	-1.0	1.2	-1.2	0.9	-0.9	-0.1
Saline control response	4.5	6.0	7.3	2.6	2.6	-2.6	2.4	-2.4	2.7	-2.0	-2.3
Bone: connectivity density	1.4	2.2	4.2	1.6	1.6	-1.5	1.2	-1.2	2.0	-0.5	-1.7
Bone: cortical apparent density	0.4	0.6	1.4	0.6	0.6	-0.7	0.9	-0.9	0.2	-1.2	0.2
Bone: cortical area	0.3	0.5	0.9	0.8	0.8	-0.8	0.8	-0.8	1.0	-0.2	-0.5
Bone: cortical porosity	0.2	0.2	0.3	0.4	0.5	-0.5	0.5	-0.5	0.3	-0.5	-0.1
Bone: cortical porosity	0.6	0.7	0.8	0.8	0.9	-0.9	0.9	-0.9	0.8	-0.7	-0.6
Bone: cortical thickness	3.7	6.2	7.2	2.6	2.6	-2.6	2.7	-2.7	2.3	-2.4	-1.8
Bone: cortical thickness	0.8	0.9	1.9	1.0	0.9	-1.0	0.8	-0.7	1.0	-0.8	-1.4
Bone: cortical tissue density	0.6	0.8	1.9	0.8	0.8	-0.9	1.1	-1.1	0.4	-1.4	0.0
Condit. Reinf. active minus inactive responses	0.1	0.2	0.2	0.4	0.4	-0.4	0.4	-0.4	0.4	-0.2	-0.4
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.5	0.4	0.4	-0.4	0.6	-0.6	0.2	-0.7	0.1
Condit. Reinf. active responses	0.0	0.0	0.3	-0.2	-0.1	0.1	-0.2	0.2	0.0	0.5	0.0
Condit. Reinf. inactive responses	0.6	0.8	1.9	-0.9	-0.8	0.8	-1.0	1.0	-0.5	1.4	0.3
Incentive salience index mean	0.1	0.2	0.5	0.4	0.4	-0.4	0.3	-0.3	0.6	0.1	-0.7
Condit. Reinf. lever presses	0.1	0.2	0.5	0.3	0.4	-0.3	0.2	-0.2	0.7	0.4	-0.5
Condit. Reinf. active minus inactive responses	0.2	0.3	0.8	-0.5	-0.5	0.5	-0.3	0.3	-0.5	0.3	0.9
Condit. Reinf. active-inactive response ratio	1.6	1.8	2.3	-1.3	-1.4	1.4	-1.3	1.3	-1.2	1.3	1.5
Condit. Reinf. active responses	0.0	0.1	0.1	0.2	0.2	-0.2	0.3	-0.3	0.2	-0.2	0.3
Condit. Reinf. inactive responses	0.9	1.2	1.4	1.1	1.1	-1.2	1.1	-1.1	1.0	-0.9	-1.0
Condit. Reinf. lever presses	0.9	1.3	1.9	1.2	1.3	-1.2	1.2	-1.2	1.4	-0.7	-0.6
Condit. Reinf. lever reinforcers received	0.2	0.3	0.5	0.5	0.6	-0.5	0.7	-0.7	0.5	-0.5	0.1
Conditioned reinforcement - actives	0.1	0.2	1.6	-0.3	-0.2	0.3	0.0	-0.1	-0.4	0.1	1.3
Conditioned reinforcement - inactives	2.9	4.3	6.3	-2.3	-2.0	2.1	-1.7	1.7	-2.2	1.9	2.5
Conditioned locomotion	8.5	11.1	13.6	-3.6	-3.5	3.6	-3.1	3.1	-3.7	2.6	3.4
Patch foraging indifference point 0 sec	0.0	0.1	0.2	-0.3	-0.2	0.2	-0.1	0.1	-0.2	0.5	0.2
Patch foraging indifference point AUC	2.3	3.3	4.5	1.8	2.0	-1.9	2.1	-2.1	1.7	-1.9	-0.6
Delay disc. indifference point, 0s delay	0.5	0.6	1.1	-0.4	-0.5	0.5	-1.0	1.0	0.0	1.0	-0.9
Delay disc. indifference point, 16s delay	0.9	0.9	1.6	-1.1	-0.9	1.0	-0.8	0.8	-0.8	1.3	0.8
Delay disc. indifference point, 2s delay	0.2	0.3	0.7	-0.3	-0.4	0.4	-0.6	0.6	-0.1	0.8	-0.2
Delay disc. indifference point, 24s delay	0.0	0.0	0.2	0.0	0.1	-0.1	0.1	-0.1	0.1	0.2	-0.4
Delay disc. indifference point, 4s delay	0.2	0.2	1.2	0.0	-0.0	0.0	-0.4	0.4	0.4	0.4	-1.1
Delay disc. indifference point, 8s delay	0.1	0.1	0.8	0.2	0.1	-0.1	-0.2	0.2	0.3	0.3	-0.9
Indifference point function ln k	5.8	10.1	12.5	-3.4	-3.5	3.3	-3.5	3.5	-3.2	3.1	1.4
Indifference point function log k	5.8	10.1	12.5	-3.4	-3.5	3.3	-3.5	3.5	-3.2	3.1	1.4
Patch foraging total patch changes 0 sec	0.0	0.0	0.0	-0.0	0.0	-0.0	0.1	-0.1	-0.0	0.1	-0.1
Patch foraging total patch changes 12 sec	4.2	5.4	6.7	2.3	2.6	-2.5	2.5	-2.5	2.6	-1.6	-1.8
Patch foraging total patch changes 18 sec	0.7	1.1	1.6	1.0	1.2	-1.1	1.2	-1.3	1.0	-0.9	-0.4
Patch foraging total patch changes 24 sec	1.5	2.6	3.4	1.5	1.8	-1.7	1.8	-1.8	1.8	-0.9	-1.3
Patch foraging total patch changes 6 sec	0.8	1.2	1.9	1.1	1.1	-1.1	0.9	-0.9	1.4	-0.4	-1.4
Patch foraging time to switch 0 sec	0.4	0.8	2.0	1.0	0.9	-0.8	0.6	-0.6	1.4	0.1	-1.1
Patch foraging water rate 0 sec	1.9	4.0	6.4	-2.3	-2.1	2.1	-1.7	1.7	-2.5	1.3	2.1
Patch foraging water rate 12 sec	3.9	8.1	11.8	-3.1	-3.2	3.0	-2.8	2.8	-3.4	1.9	2.1
Patch foraging water rate 18 sec	2.1	3.3	4.0	-1.9	-2.0	1.9	-2.0	2.0	-1.9	1.7	0.7
Patch foraging water rate 24 sec	2.6	3.6	4.9	-2.1	-2.1	2.0	-1.9	1.9	-2.2	1.5	1.4
Patch foraging water rate 6 sec	2.7	3.9	5.3	-2.2	-2.2	2.1	-2.0	2.0	-2.3	1.5	1.1
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.3	-0.5	-0.5	0.5	-0.5	0.5	-0.5	0.6	0.3
Distance traveled before self-admin	0.2	0.3	0.6	0.5	0.7	-0.6	0.6	-0.6	0.8	-0.2	-0.2
Distance traveled after self-admin	0.5	0.6	1.1	0.7	0.7	-0.7	0.9	-0.9	0.4	-1.1	0.1
Extensor digitorum longus weight	6.2	24.3	33.8	5.3	5.3	-5.2	4.6	-4.6	5.8	-3.4	-4.9
Bone: elastic displacement	0.2	0.3	0.6	-0.5	-0.6	0.5	-0.5	0.5	-0.8	-0.1	0.2
Bone: elastic work	1.2	1.6	3.0	1.3	1.2	-1.3	1.0	-1.0	1.3	-0.9	-1.7
Bone: endosteal estimation	2.0	4.3	8.5	-1.9	-2.0	2.1	-2.5	2.5	-1.2	2.9	0.5
Bone: endosteal perimeter	2.7	5.7	10.4	-2.3	-2.3	2.4	-2.6	2.7	-1.6	3.2	1.2
Epididymis fat weight	3.9	13.4	16.2	-4.0	-3.8	3.9	-3.6	3.6	-3.5	3.8	3.1
Delta time in closed arm before/after self-admin	0.4	0.4	2.2	0.4	0.2	-0.2	-0.1	0.1	0.6	0.2	-1.5
Delta time in open arm before/after self-admin	0.4	0.4	0.8	0.4	0.7	-0.6	0.9	-0.9	0.4	-0.7	0.6
Diff in mean of infusions in LGA sessions	0.7	0.8	1.0	0.9	1.0	-1.0	1.0	-1.0	1.0	-0.5	-0.8
Delay discount exponential model param	0.1	0.1	0.6	-0.1	-0.1	0.1	0.1	-0.1	-0.4	-0.5	0.8
Extinction: sum of active levers before priming	2.0	2.2	3.1	1.6	1.6	-1.5	1.4	-1.4	1.8	-1.2	-1.3
Active lever presses in extinction session 6	3.0	3.0	3.7	1.8	1.9	-1.8	1.9	-1.9	1.9	-1.6	-0.9
Bone: final force	1.4	2.2	3.9	1.6	1.6	-1.5	1.3	-1.3	2.0	-0.5	-1.6
Bone: final moment	1.3	2.1	3.8	1.5	1.6	-1.5	1.3	-1.2	1.9	-0.4	-1.6
Food consumed during 24 hour testing period	0.2	0.2	0.5	0.2	0.3	-0.2	0.6	-0.6	-0.0	-0.7	0.7
Glucose	3.7	5.8	8.1	-2.5	-2.5	2.5	-2.8	2.8	-1.9	2.8	0.9
Heart weight	1.4	2.2	3.9	-1.2	-1.4	1.4	-2.0	2.0	-0.6	1.8	-0.8
Delay discount hyperbolic model param	0.1	0.1	0.6	-0.1	-0.0	0.0	0.2	-0.2	-0.4	-0.5	0.8
Intermittent access intake day 1-15 change	0.7	1.5	4.2	-1.3	-1.1	1.2	-0.7	0.7	-1.5	0.5	2.0
Intermittent access intake escalation	0.6	1.3	4.2	-1.2	-1.0	1.0	-0.6	0.5	-1.4	0.4	2.0
Intermittent access intake escalation 2	1.1	1.3	3.7	-1.2	-1.0	1.1	-0.7	0.6	-1.3	0.6	1.9
Intermitt. access day 1 inactive lever presses	0.0	0.2	0.7	-0.2	-0.3	0.3	-0.1	0.1	-0.6	-0.3	0.8
Intermitt. access day 15 inactive lever presses	2.1	4.3	4.9	-2.2	-2.1	2.2	-1.9	1.9	-2.0	2.2	2.1
Intermitt. access escalation Index	1.8	2.6	3.3	-1.8	-1.7	1.7	-1.6	1.6	-1.8	1.3	1.2
Intermittent access day 1 total infusions	4.9	7.9	13.1	-2.8	-2.8	2.9	-3.1	3.1	-2.1	3.6	1.4
Intermittent access day 15 total infusions	6.9	10.3	11.6	-3.4	-3.3	3.4	-3.1	3.1	-3.1	3.1	3.1
Intermittent access terminal intake (last 3 days)	7.6	10.0	13.0	-3.4	-3.2	3.3	-3.2	3.1	-2.7	3.6	2.6
Intermittent access total infusions	7.3	8.7	12.0	-3.1	-3.0	3.1	-3.1	3.1	-2.4	3.5	2.1
Intermittent access day 1 locomotion	4.0	5.0	7.7	-2.3	-2.3	2.4	-2.5	2.5	-1.7	2.8	1.2
Intermittent access day 15 total locomotion	4.5	8.2	9.7	-3.1	-2.9	3.0	-2.7	2.7	-2.7	3.0	2.8
Intermittent access total locomotion	11.5	13.7	18.3	-4.0	-3.7	3.9	-3.7	3.7	-3.2	4.3	3.1
Intermittent access standard deviation	1.0	2.1	2.7	-1.5	-1.5	1.6	-1.3	1.3	-1.6	1.0	1.6
Left kidney weight	0.7	3.2	4.8	-1.9	-1.8	1.9	-2.0	2.0	-1.4	2.2	1.0
Right kidney weight	0.4	1.9	2.6	-1.5	-1.4	1.4	-1.4	1.4	-1.2	1.6	1.0
Cocaine induced anxiety	0.0	0.1	0.1	0.2	0.2	-0.2	0.3	-0.3	0.1	-0.3	0.4
Post-drug Anxiety	0.3	0.4	0.5	0.7	0.7	-0.6	0.6	-0.6	0.7	-0.4	-0.3
Baseline Anxiety	0.3	0.4	1.1	0.6	0.5	-0.6	0.4	-0.4	0.7	-0.2	-1.0
Tail length	0.9	3.3	4.9	2.0	1.8	-1.9	1.9	-1.9	1.5	-2.2	-1.4
Length with tail	2.0	8.7	10.5	3.2	3.1	-3.1	2.8	-2.7	3.2	-2.6	-2.9
Length without tail	1.8	5.8	7.8	2.6	2.5	-2.5	2.2	-2.1	2.8	-1.7	-2.7
Times rat made contact with spout	1.0	1.1	1.8	1.2	1.0	-1.1	1.1	-1.1	0.9	-1.3	-0.8
Lifetime Intake	5.3	6.5	9.2	-2.6	-2.6	2.7	-2.8	2.8	-2.0	3.0	1.5
Liver weight, left	0.7	1.2	1.9	-1.1	-1.2	1.2	-1.4	1.4	-1.0	0.9	0.3
Liver weight, right	2.0	3.4	5.2	-1.8	-2.0	1.9	-2.3	2.3	-1.5	2.0	0.1
Locomotor activity	1.0	1.5	2.3	-1.4	-1.4	1.3	-1.3	1.3	-1.5	0.8	0.6
Locomotor testing distance	1.1	2.0	2.6	-1.6	-1.6	1.5	-1.6	1.6	-1.6	1.0	0.4
Locomotor testing rearing	1.0	2.0	2.7	-1.5	-1.6	1.5	-1.7	1.7	-1.5	1.1	0.4
Locomotion in novel chamber	6.0	7.7	9.5	-3.1	-2.9	2.9	-2.7	2.7	-2.9	2.6	2.5
Locomotion in novel chamber post-restriction	2.8	4.5	5.6	-2.2	-2.2	2.2	-2.0	2.0	-2.4	1.6	2.3
Fecal boli incidents, locomotor time 1	0.1	0.1	0.5	0.0	0.1	-0.1	0.3	-0.3	0.0	-0.2	0.7
Change in fecal boli incidents, locomotor task	0.2	0.2	0.5	-0.1	-0.3	0.2	-0.5	0.5	-0.1	0.4	-0.7
Time >=10cm from walls, locomotor time 1	1.5	1.5	1.7	-1.2	-1.2	1.3	-1.3	1.3	-1.0	1.2	1.3
Bouts of movement, locomotor time 1	3.2	3.6	6.6	1.7	1.8	-1.9	2.4	-2.4	1.0	-2.6	0.2
Total resting periods, locomotor time 1	2.2	2.4	4.6	1.3	1.5	-1.5	2.0	-2.0	0.7	-2.1	0.4
Rest time, locomotor task time 1	1.2	1.5	2.7	-1.3	-1.3	1.2	-0.9	0.9	-1.6	0.6	1.6
Distance moved, locomotor task time 1	0.1	0.2	0.8	0.3	0.3	-0.3	-0.0	0.0	0.6	0.3	-0.9
Vertical activity count, locomotor time 1	0.5	1.2	1.7	-1.1	-1.2	1.1	-1.3	1.3	-1.0	1.1	0.4
Time >=10cm from walls, locomotor time 2	0.2	0.2	0.9	0.1	0.2	-0.2	0.5	-0.5	-0.1	-0.7	0.9
Bouts of movement, locomotor time 2	0.3	0.6	0.9	0.7	0.8	-0.8	0.9	-0.9	0.6	-0.7	-0.2
Total resting periods, locomotor time 2	0.1	0.2	0.3	0.4	0.5	-0.5	0.6	-0.6	0.3	-0.4	-0.0
Rest time, locomotor task time 2	2.6	3.3	3.8	-1.9	-2.0	1.9	-1.9	1.9	-1.9	1.6	1.4
Distance moved, locomotor task time 2	1.8	2.1	2.7	1.5	1.5	-1.6	1.6	-1.6	1.3	-1.6	-0.8
Vertical activity count, locomotor time 2	0.1	0.2	0.7	0.4	0.3	-0.4	0.4	-0.4	0.1	-0.8	-0.3
Light reinforcement 1	0.0	0.1	0.3	-0.0	-0.1	0.1	0.1	-0.1	-0.3	-0.4	0.5
Light reinforcement 2	1.5	2.4	4.3	-1.5	-1.5	1.6	-1.2	1.2	-1.6	1.3	2.1
Bone: marrow area	2.1	4.6	8.8	-2.0	-2.1	2.2	-2.5	2.6	-1.3	3.0	0.5
Bone: maximum diameter	0.0	0.1	0.4	-0.0	0.1	0.0	-0.0	-0.0	0.3	0.6	0.2
Bone: maximum force	1.2	2.1	5.0	1.5	1.6	-1.4	1.1	-1.1	2.2	0.1	-1.7
Bone: maximum moment	1.2	2.0	4.7	1.4	1.5	-1.4	1.1	-1.1	2.2	0.1	-1.7
Mean time between licks in bursts	0.3	0.8	2.2	0.9	0.8	-0.9	0.6	-0.6	0.9	-0.7	-1.5
Mean num. licks in bursts	0.0	0.0	0.1	-0.1	-0.2	0.1	-0.1	0.1	-0.3	-0.1	0.0
Cd content in liver	1.2	1.3	2.8	-1.3	-1.1	1.1	-0.8	0.8	-1.3	0.9	1.7
Co content in liver	0.2	0.2	0.8	-0.4	-0.5	0.3	-0.2	0.2	-0.9	-0.5	0.4
Cu content in liver	0.0	0.0	0.1	0.0	0.0	-0.0	0.2	-0.2	-0.2	-0.3	0.3
Fe content in liver	0.1	0.1	0.3	0.4	0.3	-0.3	0.2	-0.2	0.5	-0.2	-0.5
K content in liver	0.5	0.5	1.9	0.6	0.6	-0.6	0.2	-0.2	1.0	0.3	-1.4
Mg content in liver	0.5	0.5	1.0	-0.6	-0.6	0.6	-0.8	0.8	-0.3	1.0	-0.4
Mn content in liver	2.1	2.3	3.1	1.6	1.7	-1.6	1.7	-1.7	1.7	-0.9	-0.9
Na content in liver	0.3	0.3	0.5	0.6	0.6	-0.6	0.6	-0.6	0.7	-0.2	-0.6
Rb content in liver	1.8	2.1	2.9	-1.5	-1.6	1.5	-1.7	1.7	-1.5	1.2	0.6
Se content in liver	0.3	0.3	1.1	-0.5	-0.4	0.5	-0.3	0.3	-0.5	0.3	1.1
Sr content in liver	3.1	2.7	3.4	1.7	1.8	-1.7	1.9	-1.9	1.6	-1.5	-0.8
Zn content in liver	0.5	0.5	0.6	0.8	0.8	-0.7	0.8	-0.8	0.8	-0.6	-0.7
Bone: minimum diameter	2.0	3.6	7.6	-1.8	-1.8	1.9	-2.2	2.2	-1.1	2.8	0.6
Time in familiar zone, hab. session 1	0.4	0.4	1.1	-0.7	-0.6	0.6	-0.7	0.7	-0.4	1.0	0.1
Time in novel zone, hab. session 1	0.1	0.1	0.1	-0.1	-0.3	0.2	-0.4	0.4	-0.3	-0.1	-0.2
Total zone transitions, hab. session 1	0.4	0.5	0.8	0.9	0.7	-0.7	0.7	-0.7	0.7	-0.8	-0.5
Total locomotion distance, hab. session 1	0.7	1.0	1.6	-0.9	-1.1	1.1	-1.3	1.3	-0.7	1.1	0.3
Locomotion velocity, hab. session 1	0.1	0.2	0.4	-0.3	-0.5	0.5	-0.6	0.6	-0.2	0.4	0.0
Time in familiar zone, hab. session 2	0.3	0.3	1.0	0.5	0.5	-0.6	0.4	-0.4	0.5	-0.4	-1.0
Time in novel zone, hab. session 2	0.1	0.1	0.1	-0.2	-0.2	0.3	-0.2	0.2	-0.1	0.4	0.3
Total zone transitions, hab. session 2	0.5	0.7	2.1	0.8	0.7	-0.7	0.3	-0.3	1.2	0.2	-1.5
Total locomotion distance, hab. session 2	0.4	0.5	1.4	-0.4	-0.6	0.6	-0.9	0.9	0.0	1.2	-0.7
Locomotion velocity, hab. session 2	0.6	0.8	1.9	-0.7	-0.8	0.8	-1.1	1.1	-0.3	1.4	-0.3
Novel to familiar place preference ratio	0.7	0.7	1.1	0.8	1.0	-0.9	1.0	-1.0	0.9	-0.7	0.0
Novelty place preference	0.3	0.3	0.5	0.5	0.6	-0.5	0.7	-0.7	0.5	-0.5	0.3
Time in novel zone, NPP test	0.2	0.2	0.3	0.4	0.5	-0.4	0.6	-0.6	0.5	-0.4	0.1
Total zone transitions, NPP test	1.4	2.0	3.1	1.6	1.5	-1.5	1.2	-1.2	1.8	-0.8	-1.5
Total locomotion distance, NPP test	0.1	0.2	0.5	-0.1	-0.3	0.3	-0.6	0.6	0.1	0.7	-0.5
Locomotion velocity, NPP test	0.0	0.1	0.1	0.0	-0.1	0.1	-0.3	0.3	0.1	0.4	-0.3
Intraocular pressure	0.7	1.0	4.8	-0.9	-0.6	0.7	-0.0	0.0	-1.3	-0.3	2.2
Delta distance traveled before/after self-admin	0.1	0.1	0.4	0.1	-0.0	-0.1	0.1	-0.1	-0.3	-0.6	-0.1
Delta ambulatory time before/after self-admin	0.1	0.1	0.7	0.3	0.1	-0.2	0.1	-0.1	-0.1	-0.8	-0.3
Parametrial fat weight	4.2	9.9	12.3	-3.4	-3.2	3.3	-3.3	3.3	-2.8	3.5	2.2
Pavlov. Cond. lever latency	0.2	0.2	0.5	-0.4	-0.5	0.5	-0.4	0.4	-0.7	-0.1	0.6
Pavlov. Cond. magazine entry latency	0.1	0.2	0.4	0.3	0.4	-0.3	0.3	-0.3	0.6	0.3	-0.4
Pavlov. Cond. change in total contacts	0.1	0.1	0.3	-0.0	0.1	-0.1	0.3	-0.3	0.1	0.1	0.5
Pavlov. Cond. index score	0.2	0.3	0.5	0.5	0.6	-0.6	0.7	-0.7	0.6	-0.3	-0.2
Pavlov. Cond. latency score	0.1	0.1	0.3	0.3	0.4	-0.4	0.4	-0.4	0.5	-0.1	-0.3
Pavlov. Cond. lever contacts	0.1	0.1	0.3	0.2	0.2	-0.2	0.1	-0.1	0.5	0.3	-0.6
Pavlov. Cond. magazine entry number	0.4	0.5	0.9	-0.6	-0.8	0.7	-1.0	1.0	-0.6	0.7	-0.1
Pavlov. Cond. intertrial magazine entries	0.4	0.5	2.1	-0.6	-0.5	0.5	-0.1	0.1	-1.0	-0.2	1.4
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.6	0.6	0.8	-0.7	0.8	-0.8	0.8	-0.3	-0.3
Pavlov. Cond. response bias	0.2	0.3	0.4	0.4	0.6	-0.5	0.7	-0.7	0.5	-0.3	-0.0
Pavlov. Cond. lever latency	0.2	0.3	0.5	-0.5	-0.6	0.6	-0.6	0.6	-0.7	0.2	0.1
Pavlov. Cond. magazine entry latency	3.9	4.7	6.0	2.3	2.4	-2.3	2.2	-2.2	2.4	-1.7	-1.6
Pavlov. Cond. change in total contacts	0.7	1.0	1.6	1.0	1.2	-1.0	1.3	-1.3	1.1	-0.7	0.0
Pavlov. Cond. index score	1.5	2.1	2.9	1.5	1.6	-1.5	1.6	-1.6	1.7	-1.0	-0.8
Pavlov. Cond. latency score	1.1	1.5	2.3	1.3	1.4	-1.3	1.3	-1.3	1.5	-0.8	-0.6
Pavlov. Cond. lever contacts	0.3	0.4	0.6	0.6	0.7	-0.7	0.8	-0.8	0.7	-0.4	-0.1
Pavlov. Cond. magazine entry number	5.6	6.9	8.5	-2.8	-2.9	2.8	-2.8	2.8	-2.9	2.1	1.7
Pavlov. Cond. intertrial magazine entries	0.7	1.0	1.5	-1.2	-1.1	1.0	-0.9	0.9	-1.2	0.8	1.1
Pavlov. Cond. lever-magazine prob. diff.	2.0	2.7	3.6	1.7	1.9	-1.7	1.8	-1.8	1.9	-1.2	-0.9
Pavlov. Cond. response bias	1.4	1.9	2.6	1.4	1.6	-1.5	1.5	-1.5	1.6	-0.9	-0.8
Time in closed arm before self-admin	0.4	0.6	1.0	-0.9	-0.7	0.7	-0.6	0.6	-0.7	0.7	1.0
Time in closed arm after self-admin	0.6	0.6	0.8	-0.8	-0.8	0.8	-0.9	0.9	-0.7	0.9	0.2
Time in open arm before self-admin	0.2	0.2	1.5	0.1	-0.1	-0.0	-0.3	0.4	0.0	-0.0	-1.2
Time in open arm after self-admin	0.5	0.5	0.7	0.7	0.7	-0.8	0.7	-0.7	0.6	-0.9	-0.6
Bone: periosteal estimation	0.4	0.9	3.1	-0.8	-0.7	0.8	-1.0	1.0	-0.1	1.8	0.1
Bone: periosteal perimeter	0.1	0.2	1.3	-0.3	-0.2	0.3	-0.4	0.5	0.2	1.1	-0.1
Bone: post-yield work	0.7	1.1	5.0	-0.7	-0.6	0.7	-1.0	1.0	0.3	2.2	-0.0
Progressive ratio test 1 active lever presses	0.7	0.9	1.2	-1.0	-0.9	1.0	-1.0	1.0	-0.8	1.1	0.8
Progressive ratio test 1 breakpoint	0.6	0.8	1.1	-0.9	-0.9	0.9	-0.9	0.9	-0.7	1.1	0.8
Progressive ratio test 1 inactive lever presses	0.1	0.2	0.4	-0.5	-0.3	0.4	-0.3	0.3	-0.3	0.6	0.5
Progressive ratio test 2 active lever presses	4.1	4.8	5.6	-2.4	-2.2	2.3	-2.0	2.0	-2.1	2.3	2.2
Progressive ratio test 2 breakpoint	4.2	4.8	5.6	-2.4	-2.2	2.3	-2.0	2.0	-2.1	2.3	2.2
Progressive ratio test 2 inactive lever presses	7.7	12.5	15.1	-3.9	-3.6	3.7	-3.2	3.2	-3.6	3.4	3.6
Incentive Sensitization - Responses	0.3	0.5	1.6	-0.7	-0.5	0.6	-0.6	0.6	-0.3	1.3	0.5
Incentive Sensitization - Breakpoint	0.6	0.8	2.0	-0.9	-0.8	0.9	-0.8	0.8	-0.5	1.4	0.7
Sum of active levers in priming session hrs 5-6	1.9	1.8	3.1	1.0	1.2	-1.2	1.7	-1.8	0.6	-1.7	1.0
Progressive ratio	0.3	0.5	1.2	0.7	0.7	-0.6	0.3	-0.3	1.1	0.1	-0.9
Food seeking constrained by brief footshock	0.1	0.1	0.4	0.3	0.2	-0.3	0.1	-0.1	0.4	-0.2	-0.6
Seeking ratio, punishment vs. effort	0.4	0.6	1.1	-0.8	-0.9	0.8	-0.8	0.8	-1.1	0.3	0.3
Retroperitoneal fat weight	9.4	39.9	46.9	-6.8	-6.7	6.7	-6.6	6.6	-6.4	6.0	4.4
Reaction time number correct	0.3	0.5	0.7	0.7	0.8	-0.8	0.8	-0.8	0.6	-0.9	-0.4
Reaction time mean minus median	1.5	3.7	4.5	2.0	2.1	-2.0	2.1	-2.1	2.0	-1.8	-0.8
Reaction time mean minus median AUC	1.0	2.5	3.2	1.6	1.7	-1.7	1.8	-1.8	1.5	-1.7	-0.5
Reaction time num false alarms	0.1	0.1	0.2	-0.3	-0.4	0.3	-0.4	0.5	-0.4	-0.0	-0.5
Reaction time num false alarms AUC	0.1	0.2	0.9	0.4	0.3	-0.4	0.2	-0.2	0.3	-0.6	-1.0
Reaction time trials correct on left	0.3	0.5	0.7	0.7	0.8	-0.8	0.8	-0.8	0.6	-0.9	-0.4
Reaction time trials on left	0.4	0.7	0.9	0.8	0.9	-0.9	0.9	-0.9	0.7	-0.9	-0.5
Reaction time mean	0.0	0.1	0.3	0.0	0.1	-0.1	0.2	-0.2	-0.0	-0.3	0.6
Reaction time mean AUC	0.0	0.1	0.5	-0.1	0.0	0.0	0.2	-0.2	-0.1	-0.2	0.7
Median of all reaction times	0.2	0.3	0.7	-0.6	-0.5	0.6	-0.4	0.4	-0.6	0.3	0.8
Reaction time omissions	1.2	1.7	2.3	1.3	1.5	-1.5	1.5	-1.5	1.2	-1.2	-0.6
Reaction time false alarm rate	0.1	0.2	0.3	-0.3	-0.4	0.3	-0.5	0.5	-0.3	0.2	-0.5
Reaction time premature initiation rate	2.7	3.7	7.1	2.1	1.9	-1.9	1.5	-1.5	2.2	-1.2	-2.7
Reaction time premature initiations	3.6	6.3	7.5	2.7	2.6	-2.6	2.3	-2.3	2.7	-2.1	-2.7
Std. dev. reaction times	0.7	1.2	1.9	1.1	1.1	-1.1	1.3	-1.3	0.8	-1.4	0.1
Reaction time trials completed	0.4	0.7	0.9	0.8	0.9	-0.9	0.9	-0.9	0.7	-0.9	-0.5
Reaction time trials AUC	0.2	0.4	0.6	0.6	0.6	-0.7	0.7	-0.7	0.5	-0.7	-0.4
Run reversals in cocaine runway, females	0.6	0.6	2.9	0.3	0.1	-0.1	-0.4	0.4	0.8	1.0	-1.7
Run reversals in cocaine runway, males	0.1	0.1	0.1	-0.3	-0.3	0.2	-0.2	0.2	-0.3	0.1	0.2
Latency to leave start box in cocaine runway	0.4	0.4	0.7	-0.4	-0.7	0.8	-0.8	0.9	-0.4	0.6	0.3
Latency to leave start box in cocaine runway, F	0.0	0.0	0.1	-0.0	-0.2	0.3	-0.3	0.3	-0.1	-0.0	0.2
Latency to leave start box in cocaine runway, M	0.2	0.2	0.4	-0.2	-0.4	0.4	-0.6	0.6	-0.1	0.5	-0.1
Std. dev. time between licks in bursts	0.1	0.1	0.9	0.2	0.0	-0.1	-0.1	0.1	0.2	-0.1	-0.9
Total sessions with >9 infusions	0.4	0.4	1.1	-0.5	-0.6	0.6	-0.8	0.8	-0.3	1.1	-0.0
Short access day 1 total inactive lever presses	3.3	4.3	5.1	-2.2	-2.2	2.2	-2.2	2.2	-2.0	2.0	1.3
Short access day 10 total inactive lever presses	0.1	0.3	0.7	-0.5	-0.7	0.6	-0.6	0.6	-0.8	-0.1	0.5
Short access day 1 total infusions	2.6	3.5	4.4	-1.8	-2.0	2.0	-2.1	2.1	-1.6	2.1	1.0
Short access day 10 total infusions	2.1	2.7	5.6	-1.5	-1.6	1.7	-2.0	2.0	-0.9	2.4	0.4
Short access total infusions	1.8	2.3	4.0	-1.4	-1.5	1.5	-1.9	1.9	-0.9	2.0	0.1
Short access day 1 locomotion	2.1	2.6	3.1	-1.7	-1.7	1.7	-1.7	1.7	-1.5	1.8	1.1
Short access day 10 total locomotion	1.3	2.4	3.9	-1.7	-1.5	1.6	-1.6	1.6	-1.2	2.0	1.1
Short access total locomotion	2.9	3.5	5.1	-1.9	-1.9	2.0	-2.0	2.0	-1.5	2.3	1.2
One hour access (0.3 mA shock)	8.2	9.4	11.2	-3.3	-3.2	3.3	-3.0	3.0	-3.0	3.0	2.6
Compulsive drug intake	3.6	4.3	5.1	2.2	2.0	-2.1	2.0	-2.0	1.9	-2.3	-2.0
One hour access (shock baseline)	8.1	12.3	14.4	-3.8	-3.6	3.7	-3.4	3.3	-3.5	3.4	3.4
Social response proportion	0.5	0.6	0.8	0.8	0.9	-0.9	0.9	-0.9	0.8	-0.4	-0.4
Social responses	0.6	0.8	1.1	0.8	1.0	-1.0	1.0	-1.0	0.8	-0.9	-0.5
Social time	0.5	0.7	0.8	0.8	0.9	-0.9	0.9	-0.9	0.7	-0.9	-0.6
Soleus weight	3.7	10.9	13.4	-3.5	-3.6	3.5	-3.3	3.3	-3.7	2.6	2.6
Bone: stiffness	1.0	1.6	2.9	1.4	1.4	-1.3	1.2	-1.2	1.7	-0.4	-0.9
Tibialis anterior weight	9.2	31.3	37.7	6.0	6.1	-6.0	5.7	-5.7	6.1	-4.5	-4.5
Time to tail flick, vehicle, before self-admin	0.1	0.2	0.7	0.0	0.1	-0.0	-0.2	0.2	0.5	0.8	-0.5
Time to tail flick, vehicle, after self-admin	0.8	1.0	3.8	0.8	0.8	-0.8	0.3	-0.2	1.5	0.3	-1.9
Time to tail flick, test, before self-admin	3.3	3.4	6.7	-1.9	-1.8	1.8	-2.1	2.1	-1.2	2.6	0.1
Time to tail flick, test, after self-admin	0.1	0.1	0.2	0.3	0.4	-0.4	0.4	-0.4	0.3	-0.5	0.1
Delta time to tail flick, vehicle, before/after SA	0.7	0.7	1.7	0.8	0.8	-0.8	0.5	-0.5	1.0	-0.5	-1.3
Delta time to tail flick, test, before/after SA	3.8	3.9	7.7	1.9	1.9	-1.9	2.4	-2.4	1.2	-2.8	0.2
Tibia length	0.6	1.7	2.8	1.2	1.4	-1.3	1.6	-1.7	1.3	-1.0	0.2
Ambulatory time before self-admin	0.1	0.2	0.3	0.4	0.6	-0.5	0.6	-0.6	0.6	-0.2	0.2
Ambulatory time after self-admin	0.2	0.2	0.8	-0.4	-0.4	0.4	-0.2	0.2	-0.5	-0.1	0.9
Bone: tissue strength	0.0	0.0	0.2	-0.1	-0.1	0.1	0.0	-0.0	-0.2	-0.1	0.4
Total heroin consumption	6.3	7.4	8.4	2.9	2.9	-2.9	2.9	-2.9	2.7	-2.7	-1.7
Bone: trabecular number	0.2	0.4	1.0	0.6	0.6	-0.5	0.4	-0.4	1.0	0.2	-0.6
Bone: trabecular spacing	0.1	0.1	0.4	-0.3	-0.4	0.3	-0.2	0.2	-0.6	-0.2	0.2
Bone: trabecular thickness	0.7	0.8	1.0	-0.9	-1.0	1.0	-1.0	1.0	-0.8	1.0	0.6
Bone: trabecular tissue density	2.7	4.0	6.6	-2.1	-2.1	2.0	-1.7	1.7	-2.6	0.9	2.4
Water consumed over 24 hours	1.7	2.3	3.5	1.6	1.5	-1.6	1.7	-1.7	1.2	-1.9	-0.8
Number of responses in last shaping day	0.0	0.0	0.1	0.1	0.1	-0.1	0.1	-0.1	0.0	-0.3	-0.3