Hub : Genes

Bmp1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver alternative TSS XM_039093690.1 0.08 0.05 1.6e-09 0.07 0.08 0.08 0.08 2.7e-08 3.8e-09 1.5e-09 6.8e-09
2 Brain isoform ratio XR_005493807.1 0.04 0.03 7.5e-04 0.03 0.03 0.03 0.03 1.9e-03 5.4e-04 7.9e-04 9.2e-04
3 Liver alternative TSS NM_031323.1 0.06 0.04 3.9e-08 0.06 0.06 0.07 0.06 1.0e-07 1.4e-07 5.4e-08 2.6e-07
4 Adipose gene expression Bmp1 0.08 0.06 8.7e-11 0.09 0.09 0.09 0.09 3.9e-10 2.5e-10 4.6e-10 4.6e-10
5 Liver alternative TSS XM_039093690.1 0.07 0.05 6.8e-09 0.07 0.07 0.07 0.07 2.0e-08 1.8e-08 9.4e-09 1.5e-08
6 Liver gene expression Bmp1 0.11 0.07 2.5e-15 0.13 0.13 0.13 0.13 4.6e-14 2.1e-14 3.2e-14 2.4e-14
7 Adipose alternative polyA NM_031323.1 0.02 0.01 8.1e-03 0 0.01 0.01 0 1.5e-01 6.2e-02 4.9e-02 1.5e-01
8 Adipose alternative polyA XM_039093689.1 0.02 0.01 7.7e-03 0 0.01 0.01 0 1.4e-01 5.7e-02 5.0e-02 1.1e-01
9 Liver isoform ratio NM_031323.1 0.06 0.04 1.8e-07 0.06 0.06 0.06 0.06 2.0e-07 3.5e-07 6.4e-07 3.5e-07
10 NAcc gene expression Bmp1 0.04 0.03 1.6e-05 0.04 0.04 0.03 0.04 2.1e-05 3.3e-05 9.9e-05 3.5e-05
11 RMTg intron excision ratio chr15_45554903_45556368 0.1 0.08 6.9e-03 0.09 0.07 0.07 0.07 2.7e-03 6.1e-03 4.8e-03 5.7e-03
12 Liver mRNA stability Bmp1 0.04 0.03 2.6e-06 0.04 0.03 0.03 0.04 1.7e-05 9.4e-05 1.1e-04 8.3e-05
13 Brain gene expression Bmp1 0.24 0.13 0.0e+00 0.3 0.3 0.3 0.3 2.5e-28 3.9e-28 4.0e-28 2.4e-28
14 Brain isoform ratio NM_031323.1 0.04 0.03 2.8e-04 0.04 0.04 0.03 0.03 2.8e-04 1.8e-04 4.4e-04 5.8e-04
15 Liver alternative TSS NM_031323.1 0.06 0.04 6.1e-08 0.07 0.06 0.07 0.06 2.4e-08 1.9e-07 5.6e-08 1.4e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density1.42.42.61.6-1.6-1.61.61.6-1.61.6-1.5-1.5-1.51.51.5-1.51.4-1.5
Area under the delay curve0.00.00.0-0.10.00.1-0.1-0.10.1-0.10.10.10.1-0.1-0.10.1-0.10.2
BMI with tail0.51.52.2-1.31.51.2-1.4-1.21.4-1.11.01.21.2-1.2-1.21.2-1.00.9
BMI without tail0.71.41.81.1-1.0-1.11.11.1-1.11.2-1.2-1.2-1.21.31.2-1.21.3-1.3
Body weight0.41.81.9-1.31.31.3-1.3-1.31.3-1.41.41.31.3-1.3-1.31.3-1.41.4
Weight adjusted by age1.72.02.1-1.41.31.4-1.3-1.41.3-1.41.41.41.4-1.4-1.41.4-1.41.4
Bone surface0.61.01.31.1-1.1-1.11.11.1-1.11.0-1.0-1.0-1.01.01.0-1.00.9-0.9
Bone volume0.81.31.51.2-1.2-1.21.21.2-1.21.1-1.1-1.1-1.11.11.1-1.11.0-1.1
Breakpoint value in progressive ratio session0.00.00.0-0.20.20.2-0.2-0.20.2-0.20.20.20.2-0.2-0.20.2-0.20.2
Number of licking bursts0.00.00.1-0.30.20.3-0.2-0.30.2-0.20.20.10.1-0.1-0.10.1-0.10.2
Context. condit. distance diff. score0.70.81.70.4-0.5-0.60.60.6-0.70.9-1.1-1.0-1.01.01.0-1.01.3-1.0
Locomotion velocity, session 10.10.10.2-0.30.30.4-0.3-0.40.3-0.40.40.40.4-0.4-0.40.4-0.40.4
Locomotion distance, session 10.10.10.30.5-0.5-0.50.40.4-0.40.3-0.2-0.2-0.20.20.2-0.20.0-0.2
Locomotion velocity, session 20.10.10.10.4-0.4-0.30.30.3-0.30.2-0.2-0.2-0.20.20.2-0.20.1-0.1
Locomotion distance, session 20.10.10.40.6-0.6-0.50.50.4-0.50.3-0.1-0.2-0.20.20.2-0.2-0.1-0.1
Locomotion velocity, session 30.60.71.1-1.11.01.0-0.9-1.00.9-0.90.70.70.7-0.7-0.70.7-0.50.7
Locomotion distance, session 30.00.00.1-0.10.00.00.00.0-0.10.1-0.1-0.2-0.20.20.2-0.20.3-0.2
Stereotopy head waving bouts, day 30.60.70.8-0.90.80.9-0.8-0.90.8-0.90.90.90.9-0.8-0.90.9-0.80.9
Stereotopy head waving duration, day 32.53.03.2-1.71.61.7-1.7-1.71.7-1.81.81.81.8-1.7-1.81.8-1.81.8
Locomotion velocity, session 73.94.36.31.7-1.6-1.81.81.9-1.92.1-2.3-2.2-2.22.32.2-2.22.5-2.3
Locomotion distance, session 73.03.85.21.6-1.6-1.81.71.8-1.82.0-2.1-2.0-2.02.12.0-2.02.3-2.1
Stereotopy head waving bouts, day 71.71.92.2-1.31.21.3-1.3-1.31.3-1.41.41.51.5-1.3-1.51.5-1.51.3
Stereotopy head waving duration, day 72.42.93.1-1.71.61.7-1.7-1.71.7-1.71.81.81.8-1.7-1.81.8-1.81.7
Locomotion velocity, session 80.00.00.0-0.10.10.1-0.1-0.10.10.0-0.1-0.1-0.10.10.1-0.10.2-0.1
Locomotion distance, session 80.60.91.00.9-0.9-0.90.90.9-0.90.9-1.0-1.0-1.01.01.0-1.01.0-0.9
Degree of sensitization distance4.34.35.11.9-1.9-2.01.92.0-2.02.1-2.2-2.1-2.12.22.1-2.12.3-2.2
Degree of sensitization stereotypy1.21.31.4-1.11.11.1-1.1-1.11.1-1.11.21.21.2-1.1-1.21.2-1.21.1
Conditioned locomotion0.00.00.10.1-0.0-0.10.10.1-0.10.2-0.2-0.2-0.20.20.2-0.20.3-0.2
Cocaine response after cond. corrected0.40.50.9-1.00.90.9-0.8-0.80.8-0.60.50.50.5-0.5-0.50.5-0.30.6
Cocaine response after cond. not corrected0.20.20.4-0.70.70.6-0.6-0.60.6-0.40.30.40.4-0.4-0.40.4-0.30.4
Cocaine response before conditioning0.30.30.70.9-0.7-0.80.70.7-0.60.6-0.4-0.4-0.40.40.4-0.40.2-0.5
Saline control response0.30.30.50.7-0.7-0.70.70.7-0.60.6-0.5-0.5-0.50.50.5-0.50.4-0.5
Bone: connectivity density2.84.34.52.1-2.1-2.12.12.1-2.12.1-2.1-2.1-2.12.12.1-2.12.0-2.0
Bone: cortical apparent density0.00.00.2-0.20.30.1-0.2-0.10.10.1-0.2-0.2-0.20.20.2-0.20.4-0.3
Bone: cortical area0.00.00.00.2-0.1-0.20.10.2-0.10.1-0.1-0.0-0.00.10.0-0.00.0-0.1
Bone: cortical porosity1.21.32.0-0.90.91.0-1.0-1.01.1-1.21.31.31.3-1.3-1.31.3-1.41.2
Bone: cortical porosity0.50.50.9-0.40.50.5-0.5-0.50.6-0.70.80.80.8-0.8-0.80.8-1.00.8
Bone: cortical thickness0.00.00.10.2-0.2-0.30.20.3-0.20.3-0.3-0.1-0.10.20.1-0.10.2-0.3
Bone: cortical thickness0.00.00.10.00.0-0.10.00.1-0.10.2-0.3-0.2-0.20.20.2-0.20.3-0.3
Bone: cortical tissue density0.00.00.2-0.30.30.1-0.2-0.10.10.1-0.2-0.2-0.20.10.2-0.20.4-0.3
Condit. Reinf. active minus inactive responses0.40.40.6-0.60.50.6-0.5-0.60.6-0.70.70.70.7-0.6-0.70.7-0.70.8
Condit. Reinf. active-inactive response ratio2.12.22.4-1.51.61.5-1.5-1.51.5-1.51.51.51.5-1.4-1.51.5-1.41.4
Condit. Reinf. active responses0.00.00.10.2-0.3-0.10.20.1-0.20.00.1-0.0-0.00.10.0-0.0-0.10.2
Condit. Reinf. inactive responses3.23.95.12.3-2.2-2.22.12.1-2.12.0-1.8-1.9-1.91.81.9-1.91.6-1.8
Incentive salience index mean0.60.71.1-0.70.60.8-0.7-0.80.7-0.91.00.90.9-0.9-0.90.9-1.11.0
Condit. Reinf. lever presses0.20.20.5-0.20.20.3-0.2-0.30.3-0.40.60.50.5-0.6-0.50.5-0.70.6
Condit. Reinf. active minus inactive responses0.30.40.50.7-0.6-0.70.60.7-0.60.7-0.7-0.6-0.60.60.6-0.60.6-0.7
Condit. Reinf. active-inactive response ratio0.20.20.3-0.50.50.5-0.5-0.40.5-0.40.40.40.4-0.4-0.40.4-0.30.3
Condit. Reinf. active responses0.91.31.51.2-1.1-1.21.11.2-1.11.2-1.2-1.1-1.11.11.1-1.11.1-1.2
Condit. Reinf. inactive responses2.43.03.41.8-1.8-1.81.81.8-1.81.7-1.7-1.7-1.71.71.7-1.71.6-1.7
Condit. Reinf. lever presses0.10.20.50.7-0.6-0.60.60.6-0.50.4-0.3-0.3-0.30.30.3-0.30.1-0.3
Condit. Reinf. lever reinforcers received0.60.91.11.0-1.0-1.00.91.0-0.91.0-0.9-0.9-0.90.90.9-0.90.8-0.9
Conditioned reinforcement - actives2.62.63.01.5-1.5-1.61.51.6-1.51.7-1.7-1.7-1.71.71.7-1.71.7-1.7
Conditioned reinforcement - inactives3.13.53.81.9-2.0-1.91.91.9-1.91.9-1.8-1.8-1.81.81.8-1.81.7-1.8
Conditioned locomotion1.01.21.51.1-1.0-1.11.11.1-1.11.2-1.2-1.1-1.11.11.1-1.11.1-1.1
Patch foraging indifference point 0 sec2.43.95.82.2-2.4-2.12.32.0-2.21.9-1.7-1.9-1.91.91.9-1.91.5-1.5
Patch foraging indifference point AUC0.60.70.9-0.90.90.9-0.9-0.90.9-0.90.80.70.7-0.7-0.70.7-0.60.7
Delay disc. indifference point, 0s delay0.50.50.80.8-0.9-0.80.90.7-0.80.6-0.5-0.6-0.60.60.7-0.70.5-0.5
Delay disc. indifference point, 16s delay0.30.30.30.5-0.5-0.50.50.5-0.50.6-0.6-0.5-0.50.50.5-0.50.5-0.5
Delay disc. indifference point, 2s delay1.41.51.9-1.21.01.2-1.1-1.21.1-1.31.41.31.3-1.3-1.21.2-1.41.3
Delay disc. indifference point, 24s delay0.20.20.3-0.50.50.5-0.5-0.50.5-0.40.40.40.4-0.4-0.40.4-0.30.4
Delay disc. indifference point, 4s delay1.51.61.7-1.31.31.3-1.3-1.31.3-1.31.21.21.2-1.2-1.21.2-1.21.3
Delay disc. indifference point, 8s delay0.10.10.10.3-0.3-0.20.30.2-0.30.2-0.2-0.2-0.20.20.2-0.20.2-0.2
Indifference point function ln k0.10.10.20.5-0.4-0.40.30.4-0.30.3-0.3-0.1-0.10.10.1-0.1-0.1-0.2
Indifference point function log k0.10.10.20.5-0.4-0.40.30.4-0.30.3-0.3-0.1-0.10.10.1-0.1-0.1-0.2
Patch foraging total patch changes 0 sec2.03.35.02.1-2.2-1.92.11.9-2.01.7-1.6-1.7-1.71.71.7-1.71.4-1.4
Patch foraging total patch changes 12 sec0.81.11.71.1-1.3-1.01.21.0-1.20.9-0.8-1.0-1.01.01.0-1.00.8-0.7
Patch foraging total patch changes 18 sec2.02.63.11.5-1.8-1.51.71.5-1.71.5-1.5-1.7-1.71.71.7-1.71.6-1.3
Patch foraging total patch changes 24 sec0.10.10.20.5-0.5-0.40.40.4-0.30.2-0.0-0.2-0.20.20.2-0.2-0.1-0.2
Patch foraging total patch changes 6 sec0.30.40.60.5-0.8-0.40.80.4-0.70.5-0.5-0.7-0.70.70.7-0.70.6-0.3
Patch foraging time to switch 0 sec0.61.01.20.9-1.0-0.81.10.9-1.10.9-0.9-1.1-1.11.11.1-1.11.1-0.8
Patch foraging water rate 0 sec0.30.50.7-0.60.60.6-0.6-0.60.7-0.70.70.80.8-0.8-0.80.8-0.80.7
Patch foraging water rate 12 sec0.50.81.1-0.70.80.7-0.9-0.70.9-0.80.81.01.0-1.0-1.01.0-1.10.8
Patch foraging water rate 18 sec2.94.04.6-1.92.11.9-2.1-1.92.1-1.91.92.12.1-2.1-2.12.1-2.01.7
Patch foraging water rate 24 sec0.10.20.3-0.50.60.4-0.5-0.40.5-0.30.20.40.4-0.4-0.40.4-0.30.2
Patch foraging water rate 6 sec1.82.63.4-1.31.51.4-1.6-1.41.6-1.51.61.81.8-1.8-1.81.8-1.91.5
Seeking ratio, delayed vs. immediate footshock1.11.21.51.2-1.2-1.21.21.2-1.21.2-1.2-1.0-1.01.01.0-1.01.0-1.1
Distance traveled before self-admin1.01.01.4-0.80.80.9-0.8-0.90.9-1.01.11.11.1-1.1-1.11.1-1.21.1
Distance traveled after self-admin2.42.62.9-1.71.71.7-1.7-1.71.7-1.61.61.61.6-1.6-1.61.6-1.51.6
Extensor digitorum longus weight13.051.353.7-7.37.17.3-7.1-7.37.1-7.37.27.17.1-7.1-7.17.1-7.07.2
Bone: elastic displacement0.80.91.51.2-1.1-1.21.01.1-1.01.0-0.9-0.8-0.80.90.8-0.80.7-1.0
Bone: elastic work0.50.71.51.2-1.0-1.10.91.1-0.90.9-0.7-0.6-0.60.70.6-0.60.4-0.8
Bone: endosteal estimation0.10.30.4-0.50.40.5-0.5-0.50.5-0.60.60.60.6-0.5-0.60.6-0.60.6
Bone: endosteal perimeter0.10.10.3-0.20.20.3-0.2-0.30.3-0.40.40.40.4-0.4-0.40.4-0.50.5
Epididymis fat weight1.94.55.51.8-2.2-1.82.21.8-2.22.0-2.1-2.3-2.32.32.3-2.32.3-1.7
Delta time in closed arm before/after self-admin2.32.32.81.6-1.7-1.61.61.6-1.61.5-1.5-1.4-1.41.51.4-1.41.3-1.4
Delta time in open arm before/after self-admin0.00.00.10.1-0.1-0.10.10.1-0.10.1-0.1-0.3-0.30.00.2-0.20.2-0.2
Diff in mean of infusions in LGA sessions2.83.13.4-1.81.81.8-1.8-1.81.8-1.81.81.71.7-1.7-1.71.7-1.71.7
Delay discount exponential model param0.10.20.20.4-0.3-0.40.40.4-0.40.4-0.4-0.4-0.40.40.4-0.40.4-0.4
Extinction: sum of active levers before priming2.62.63.01.6-1.5-1.61.51.6-1.61.6-1.6-1.6-1.61.71.7-1.71.6-1.6
Active lever presses in extinction session 60.40.40.50.6-0.5-0.60.50.6-0.60.7-0.7-0.7-0.70.60.6-0.60.7-0.7
Bone: final force0.10.20.2-0.30.40.3-0.4-0.30.4-0.40.40.50.5-0.4-0.50.5-0.40.3
Bone: final moment0.10.10.2-0.20.30.2-0.3-0.20.3-0.30.30.40.4-0.3-0.40.4-0.40.3
Food consumed during 24 hour testing period0.30.30.60.7-0.7-0.70.70.6-0.70.6-0.5-0.5-0.50.50.5-0.50.4-0.4
Glucose0.00.00.1-0.20.10.1-0.0-0.1-0.00.0-0.1-0.2-0.20.20.2-0.20.3-0.1
Heart weight0.00.00.1-0.0-0.20.10.2-0.1-0.2-0.10.0-0.1-0.10.10.1-0.10.00.2
Delay discount hyperbolic model param0.40.40.50.6-0.6-0.70.60.7-0.60.7-0.7-0.7-0.70.70.7-0.70.7-0.7
Intermittent access intake day 1-15 change2.02.02.11.4-1.5-1.41.51.4-1.51.4-1.3-1.4-1.41.41.4-1.41.4-1.4
Intermittent access intake escalation1.31.31.31.1-1.1-1.11.11.1-1.11.1-1.0-1.1-1.11.11.1-1.11.1-1.1
Intermittent access intake escalation 20.40.40.40.6-0.6-0.60.60.6-0.60.6-0.6-0.6-0.60.60.6-0.60.6-0.6
Intermitt. access day 1 inactive lever presses0.10.10.10.3-0.3-0.30.30.3-0.30.3-0.3-0.3-0.30.30.3-0.30.3-0.3
Intermitt. access day 15 inactive lever presses0.00.00.10.2-0.3-0.20.20.1-0.20.1-0.0-0.1-0.10.10.1-0.10.0-0.1
Intermitt. access escalation Index0.50.50.5-0.70.70.7-0.7-0.70.7-0.70.70.60.6-0.6-0.60.6-0.60.6
Intermittent access day 1 total infusions0.00.00.10.2-0.1-0.20.20.2-0.20.3-0.3-0.2-0.20.20.2-0.20.2-0.2
Intermittent access day 15 total infusions0.91.01.11.0-1.0-1.01.01.0-1.01.0-1.0-1.0-1.01.01.0-1.01.0-1.0
Intermittent access terminal intake (last 3 days)0.20.20.30.4-0.3-0.40.40.4-0.40.5-0.5-0.4-0.40.40.4-0.40.5-0.5
Intermittent access total infusions0.40.40.60.6-0.5-0.60.60.6-0.60.7-0.7-0.7-0.70.70.7-0.70.7-0.7
Intermittent access day 1 locomotion0.30.30.40.6-0.7-0.60.60.6-0.60.6-0.5-0.6-0.60.60.6-0.60.5-0.5
Intermittent access day 15 total locomotion1.51.61.71.2-1.2-1.21.21.2-1.21.3-1.3-1.3-1.31.31.3-1.31.3-1.3
Intermittent access total locomotion0.50.50.50.7-0.7-0.70.70.7-0.70.7-0.7-0.7-0.70.70.7-0.70.7-0.7
Intermittent access standard deviation1.21.31.51.2-1.2-1.21.21.2-1.21.1-1.1-1.1-1.11.11.1-1.11.1-1.1
Left kidney weight0.30.91.1-0.90.80.9-0.8-0.90.9-1.01.00.90.9-1.0-0.90.9-1.01.0
Right kidney weight0.10.20.60.3-0.8-0.20.70.2-0.70.2-0.2-0.5-0.50.50.5-0.50.30.2
Cocaine induced anxiety0.10.10.4-0.0-0.00.1-0.1-0.20.1-0.30.40.40.4-0.4-0.40.4-0.60.5
Post-drug Anxiety0.60.60.90.9-1.0-0.90.90.8-0.90.8-0.7-0.7-0.70.70.7-0.70.6-0.7
Baseline Anxiety0.80.81.00.8-0.8-0.90.80.9-0.81.0-1.0-0.9-0.90.90.9-0.91.0-1.0
Tail length0.92.63.51.6-1.9-1.61.81.5-1.81.5-1.4-1.6-1.61.71.6-1.61.5-1.3
Length with tail0.10.30.9-0.50.20.6-0.3-0.70.3-0.70.80.50.5-0.5-0.50.5-0.70.9
Length without tail3.88.39.0-2.82.72.9-2.8-2.92.8-3.03.02.92.9-2.9-2.82.8-3.03.0
Times rat made contact with spout0.40.50.50.6-0.6-0.60.60.7-0.70.7-0.7-0.7-0.70.70.7-0.70.7-0.7
Lifetime Intake0.40.40.60.6-0.6-0.60.60.6-0.60.7-0.8-0.7-0.70.70.7-0.70.7-0.7
Liver weight, left2.33.63.8-1.91.91.9-1.9-2.01.9-1.91.91.91.9-1.9-1.91.9-1.92.0
Liver weight, right0.81.31.5-1.21.21.2-1.1-1.21.1-1.21.11.11.1-1.1-1.11.1-1.11.2
Locomotor activity1.11.73.6-0.60.90.7-1.0-0.81.1-1.21.51.61.6-1.6-1.61.6-1.91.2
Locomotor testing distance0.20.31.21.1-0.7-1.00.60.9-0.40.5-0.10.00.00.0-0.00.0-0.4-0.5
Locomotor testing rearing0.50.81.91.4-1.4-1.21.21.1-1.10.7-0.4-0.5-0.50.60.5-0.50.1-0.5
Locomotion in novel chamber0.20.30.40.6-0.6-0.60.60.6-0.60.5-0.5-0.4-0.40.40.4-0.40.4-0.4
Locomotion in novel chamber post-restriction0.70.80.9-0.90.90.9-0.9-0.90.9-0.80.80.90.9-0.9-0.90.9-0.80.9
Fecal boli incidents, locomotor time 10.70.81.0-0.90.80.9-0.8-0.90.8-0.91.01.01.0-1.0-0.80.8-0.90.9
Change in fecal boli incidents, locomotor task0.10.10.2-0.40.40.4-0.4-0.40.4-0.30.30.30.3-0.3-0.30.3-0.30.3
Time >=10cm from walls, locomotor time 11.11.11.31.2-1.1-1.11.11.1-1.11.1-1.1-1.0-1.00.90.9-0.91.0-1.0
Bouts of movement, locomotor time 15.35.76.1-2.52.52.4-2.4-2.42.4-2.42.32.42.4-2.4-2.42.4-2.22.3
Total resting periods, locomotor time 15.25.76.4-2.52.52.5-2.5-2.42.5-2.42.32.42.4-2.3-2.42.4-2.22.2
Rest time, locomotor task time 13.33.63.9-2.02.02.0-2.0-2.02.0-1.91.81.91.9-1.8-1.91.9-1.81.8
Distance moved, locomotor task time 13.33.63.82.0-1.9-1.91.91.9-1.91.9-1.9-1.9-1.91.91.8-1.81.9-1.9
Vertical activity count, locomotor time 11.21.31.81.3-1.3-1.21.31.2-1.21.1-1.0-1.1-1.11.11.1-1.10.9-0.9
Time >=10cm from walls, locomotor time 20.40.40.5-0.60.60.6-0.6-0.60.6-0.70.70.60.6-0.6-0.70.7-0.70.6
Bouts of movement, locomotor time 24.24.55.1-2.32.22.2-2.2-2.22.1-2.22.12.12.1-2.0-2.12.1-1.92.0
Total resting periods, locomotor time 24.95.26.0-2.42.42.4-2.4-2.42.3-2.32.32.22.2-2.2-2.22.2-2.12.1
Rest time, locomotor task time 21.21.42.1-1.41.41.3-1.4-1.31.3-1.21.11.11.1-1.0-1.01.0-1.01.1
Distance moved, locomotor task time 23.13.64.52.1-2.1-2.02.12.0-2.01.9-1.8-1.8-1.81.81.7-1.71.7-1.7
Vertical activity count, locomotor time 20.50.50.90.9-1.0-0.80.90.8-0.80.6-0.5-0.7-0.70.60.6-0.60.4-0.5
Light reinforcement 13.46.37.32.5-2.3-2.52.32.6-2.42.6-2.7-2.5-2.52.52.5-2.52.6-2.7
Light reinforcement 21.01.32.50.6-0.9-0.71.00.8-1.11.0-1.3-1.4-1.41.31.4-1.41.6-1.0
Bone: marrow area0.10.20.2-0.30.30.4-0.3-0.40.3-0.40.40.40.4-0.4-0.40.4-0.50.5
Bone: maximum diameter0.40.70.7-0.90.80.8-0.8-0.80.8-0.80.80.80.8-0.8-0.80.8-0.80.8
Bone: maximum force0.20.30.5-0.40.50.5-0.5-0.50.6-0.60.60.70.7-0.6-0.70.7-0.70.6
Bone: maximum moment0.10.20.3-0.20.20.2-0.3-0.20.3-0.30.40.50.5-0.4-0.50.5-0.60.4
Mean time between licks in bursts2.23.13.61.9-1.8-1.91.81.8-1.81.8-1.8-1.7-1.71.71.7-1.71.6-1.7
Mean num. licks in bursts0.40.50.60.8-0.7-0.80.70.8-0.70.8-0.8-0.7-0.70.70.7-0.70.7-0.7
Cd content in liver0.30.30.40.5-0.5-0.50.60.6-0.60.6-0.6-0.6-0.60.60.6-0.60.6-0.6
Co content in liver4.24.95.8-2.42.42.3-2.3-2.32.3-2.22.12.12.1-2.1-2.12.1-2.02.0
Cu content in liver0.60.70.8-0.90.80.9-0.8-0.90.8-0.90.80.80.8-0.8-0.80.8-0.70.8
Fe content in liver2.12.52.61.6-1.6-1.61.61.6-1.61.6-1.6-1.6-1.61.61.6-1.61.5-1.5
K content in liver0.60.60.70.7-0.7-0.70.70.7-0.70.8-0.8-0.8-0.80.80.8-0.80.8-0.7
Mg content in liver1.21.21.41.0-1.0-1.01.11.1-1.11.1-1.1-1.1-1.11.11.1-1.11.2-1.1
Mn content in liver2.12.42.51.6-1.6-1.61.61.6-1.61.6-1.5-1.5-1.51.51.5-1.51.5-1.5
Na content in liver0.50.51.2-0.30.30.4-0.4-0.50.5-0.70.80.80.8-0.8-0.80.8-1.10.9
Rb content in liver0.20.20.50.1-0.3-0.20.30.2-0.40.4-0.5-0.5-0.50.50.5-0.50.7-0.4
Se content in liver1.31.62.71.6-1.6-1.51.41.5-1.41.3-1.1-1.0-1.01.01.0-1.00.8-1.1
Sr content in liver0.50.50.60.7-0.7-0.70.70.7-0.70.7-0.7-0.7-0.70.70.7-0.70.6-0.7
Zn content in liver0.80.91.5-0.60.70.7-0.8-0.80.8-0.91.01.01.0-1.0-1.01.0-1.21.0
Bone: minimum diameter0.10.20.4-0.20.30.3-0.3-0.30.4-0.40.50.60.6-0.5-0.60.6-0.70.5
Time in familiar zone, hab. session 10.10.10.1-0.30.30.3-0.3-0.30.2-0.20.20.20.2-0.2-0.20.2-0.10.2
Time in novel zone, hab. session 11.31.31.6-1.21.21.2-1.2-1.21.2-1.21.11.11.1-1.1-1.11.1-1.01.0
Total zone transitions, hab. session 10.10.20.3-0.30.20.3-0.3-0.40.3-0.50.50.50.5-0.5-0.50.5-0.60.5
Total locomotion distance, hab. session 10.00.10.20.4-0.4-0.30.30.3-0.30.2-0.1-0.1-0.10.10.1-0.1-0.1-0.0
Locomotion velocity, hab. session 10.20.30.80.9-0.8-0.80.70.7-0.70.5-0.4-0.4-0.40.40.4-0.40.2-0.4
Time in familiar zone, hab. session 22.62.63.8-2.01.81.9-1.8-1.81.7-1.71.51.41.4-1.4-1.41.4-1.31.6
Time in novel zone, hab. session 21.01.01.51.2-1.1-1.21.11.1-1.01.0-0.9-0.9-0.90.90.9-0.90.8-1.0
Total zone transitions, hab. session 21.21.52.3-1.01.01.1-1.1-1.11.1-1.31.41.31.3-1.3-1.31.3-1.51.3
Total locomotion distance, hab. session 20.20.20.5-0.30.30.4-0.3-0.40.4-0.50.60.50.5-0.5-0.50.5-0.70.6
Locomotion velocity, hab. session 20.40.61.0-0.60.50.6-0.6-0.70.6-0.80.90.80.8-0.8-0.80.8-1.00.9
Novel to familiar place preference ratio1.81.92.41.5-1.5-1.51.41.5-1.41.4-1.3-1.3-1.31.31.3-1.31.2-1.3
Novelty place preference1.51.51.91.4-1.3-1.31.31.3-1.31.3-1.2-1.1-1.11.11.1-1.11.1-1.2
Time in novel zone, NPP test0.70.81.01.0-1.0-1.00.91.0-0.90.9-0.8-0.8-0.80.80.8-0.80.7-0.8
Total zone transitions, NPP test0.30.40.70.8-0.8-0.70.80.7-0.70.6-0.5-0.5-0.50.50.5-0.50.3-0.4
Total locomotion distance, NPP test3.04.15.22.2-2.3-2.12.22.1-2.22.0-1.9-1.9-1.91.91.9-1.91.7-1.7
Locomotion velocity, NPP test2.84.05.12.2-2.3-2.12.22.1-2.12.0-1.9-1.9-1.91.91.9-1.91.7-1.7
Intraocular pressure0.81.11.51.2-1.0-1.21.01.2-1.01.2-1.1-0.9-0.90.90.9-0.90.9-1.2
Delta distance traveled before/after self-admin2.62.83.9-1.92.01.8-1.9-1.81.8-1.71.51.61.6-1.6-1.61.6-1.41.5
Delta ambulatory time before/after self-admin2.42.73.5-1.81.91.7-1.8-1.71.7-1.61.51.51.5-1.6-1.51.5-1.41.4
Parametrial fat weight3.05.86.72.2-2.5-2.12.52.1-2.52.3-2.3-2.6-2.62.52.6-2.62.6-2.0
Pavlov. Cond. lever latency0.00.00.0-0.20.20.1-0.2-0.10.1-0.1-0.00.00.00.0-0.00.00.1-0.1
Pavlov. Cond. magazine entry latency0.00.10.10.3-0.3-0.30.20.3-0.20.2-0.2-0.2-0.20.20.2-0.20.2-0.3
Pavlov. Cond. change in total contacts0.90.91.3-0.80.80.9-0.9-0.90.9-1.01.01.01.0-1.0-1.01.0-1.11.0
Pavlov. Cond. index score0.00.00.1-0.10.10.1-0.1-0.10.2-0.20.30.20.2-0.3-0.20.2-0.30.2
Pavlov. Cond. latency score0.00.00.00.1-0.0-0.00.0-0.00.0-0.10.10.10.1-0.1-0.10.1-0.20.1
Pavlov. Cond. lever contacts0.00.00.10.2-0.3-0.20.20.2-0.20.1-0.1-0.1-0.10.00.1-0.1-0.00.0
Pavlov. Cond. magazine entry number0.40.50.50.7-0.7-0.70.70.7-0.70.7-0.7-0.7-0.70.70.7-0.70.7-0.7
Pavlov. Cond. intertrial magazine entries0.10.10.30.5-0.6-0.40.50.4-0.50.3-0.3-0.3-0.30.30.3-0.30.1-0.2
Pavlov. Cond. lever-magazine prob. diff.0.10.10.2-0.30.30.3-0.3-0.30.3-0.40.40.40.4-0.4-0.40.4-0.50.4
Pavlov. Cond. response bias0.10.10.2-0.30.30.3-0.3-0.40.4-0.40.40.40.4-0.4-0.40.4-0.50.4
Pavlov. Cond. lever latency0.30.40.70.4-0.4-0.40.40.5-0.50.6-0.8-0.7-0.70.70.7-0.70.8-0.7
Pavlov. Cond. magazine entry latency0.10.10.30.5-0.5-0.50.50.5-0.40.3-0.2-0.3-0.30.30.3-0.30.1-0.3
Pavlov. Cond. change in total contacts1.52.02.5-1.31.21.3-1.3-1.41.3-1.51.61.51.5-1.5-1.51.5-1.61.5
Pavlov. Cond. index score0.40.50.9-0.50.40.5-0.5-0.60.6-0.80.90.80.8-0.8-0.80.8-1.00.8
Pavlov. Cond. latency score0.20.30.6-0.30.20.4-0.3-0.40.4-0.60.70.60.6-0.6-0.60.6-0.80.6
Pavlov. Cond. lever contacts0.30.40.8-0.30.30.4-0.4-0.40.4-0.60.80.70.7-0.7-0.70.7-0.90.7
Pavlov. Cond. magazine entry number0.10.10.2-0.40.50.4-0.4-0.30.4-0.20.10.20.2-0.2-0.20.2-0.10.2
Pavlov. Cond. intertrial magazine entries6.28.18.52.9-2.8-2.92.82.9-2.82.9-2.9-2.8-2.82.82.8-2.82.7-2.8
Pavlov. Cond. lever-magazine prob. diff.0.50.61.0-0.60.50.7-0.6-0.70.7-0.91.00.90.9-0.9-0.90.9-1.00.9
Pavlov. Cond. response bias0.30.50.9-0.40.40.5-0.4-0.50.5-0.70.90.80.8-0.8-0.80.8-1.00.8
Time in closed arm before self-admin2.12.42.8-1.61.71.6-1.6-1.61.6-1.61.51.51.5-1.6-1.41.4-1.41.4
Time in closed arm after self-admin0.60.70.7-0.80.80.8-0.8-0.80.8-0.80.80.80.8-0.8-0.80.8-0.80.8
Time in open arm before self-admin0.10.10.2-0.30.20.3-0.2-0.30.3-0.40.40.40.4-0.2-0.40.4-0.40.4
Time in open arm after self-admin0.10.10.10.3-0.3-0.30.30.3-0.30.3-0.3-0.4-0.40.30.4-0.40.3-0.3
Bone: periosteal estimation0.00.10.1-0.20.20.2-0.2-0.20.2-0.20.30.30.3-0.3-0.30.3-0.30.3
Bone: periosteal perimeter0.00.00.0-0.00.00.0-0.1-0.00.1-0.10.10.20.2-0.1-0.20.2-0.20.1
Bone: post-yield work0.10.10.30.2-0.2-0.20.30.2-0.30.4-0.5-0.4-0.40.40.4-0.40.5-0.3
Progressive ratio test 1 active lever presses0.30.30.6-0.70.80.7-0.7-0.60.7-0.50.40.50.5-0.5-0.50.5-0.30.4
Progressive ratio test 1 breakpoint0.20.20.4-0.60.70.5-0.6-0.50.5-0.40.30.30.3-0.3-0.30.3-0.10.2
Progressive ratio test 1 inactive lever presses1.61.71.91.3-1.2-1.31.21.3-1.31.3-1.3-1.3-1.31.31.3-1.31.4-1.4
Progressive ratio test 2 active lever presses0.20.20.40.2-0.1-0.30.20.3-0.20.4-0.6-0.5-0.50.50.5-0.50.6-0.6
Progressive ratio test 2 breakpoint0.20.20.40.3-0.3-0.40.30.4-0.40.5-0.6-0.5-0.50.50.5-0.50.7-0.6
Progressive ratio test 2 inactive lever presses0.40.40.50.6-0.6-0.60.60.7-0.60.7-0.7-0.7-0.70.70.7-0.70.7-0.7
Incentive Sensitization - Responses1.01.01.21.0-0.9-1.01.01.0-1.01.1-1.1-1.0-1.01.01.0-1.01.0-1.0
Incentive Sensitization - Breakpoint1.41.41.61.2-1.2-1.21.21.2-1.21.2-1.3-1.2-1.21.21.2-1.21.2-1.2
Sum of active levers in priming session hrs 5-60.00.00.10.0-0.0-0.10.10.1-0.10.2-0.2-0.2-0.20.40.2-0.20.4-0.3
Progressive ratio0.10.10.20.3-0.3-0.30.30.4-0.40.4-0.4-0.4-0.40.40.4-0.40.4-0.4
Food seeking constrained by brief footshock1.61.93.3-1.71.81.6-1.7-1.51.6-1.31.11.31.3-1.3-1.31.3-1.01.1
Seeking ratio, punishment vs. effort1.01.31.8-1.31.31.2-1.3-1.21.2-1.11.01.11.1-1.1-1.11.1-0.91.0
Retroperitoneal fat weight0.10.30.70.0-0.5-0.00.50.1-0.60.3-0.5-0.7-0.70.70.8-0.80.8-0.1
Reaction time number correct0.60.91.2-1.01.11.0-1.1-0.91.0-0.90.80.90.9-0.9-0.90.9-0.80.8
Reaction time mean minus median0.10.10.3-0.20.30.3-0.3-0.30.3-0.40.50.40.4-0.4-0.40.4-0.60.4
Reaction time mean minus median AUC0.10.10.2-0.20.20.2-0.3-0.30.3-0.40.40.30.3-0.4-0.30.3-0.40.3
Reaction time num false alarms0.00.00.1-0.10.20.1-0.2-0.10.2-0.10.20.20.2-0.3-0.20.2-0.30.1
Reaction time num false alarms AUC0.00.00.00.00.0-0.1-0.10.10.10.00.00.00.0-0.1-0.00.0-0.2-0.1
Reaction time trials correct on left0.60.91.2-1.01.11.0-1.1-0.91.0-0.90.80.90.9-0.9-0.90.9-0.80.8
Reaction time trials on left0.40.60.9-0.91.00.8-0.9-0.80.9-0.70.70.70.7-0.8-0.70.7-0.70.6
Reaction time mean0.10.20.2-0.30.30.3-0.3-0.30.3-0.40.50.40.4-0.4-0.40.4-0.50.4
Reaction time mean AUC0.20.30.5-0.40.50.4-0.5-0.50.5-0.60.70.60.6-0.6-0.60.6-0.70.5
Median of all reaction times0.10.10.1-0.30.20.3-0.2-0.30.2-0.30.30.20.2-0.2-0.20.2-0.20.4
Reaction time omissions2.53.43.91.9-1.8-2.01.82.0-1.81.9-1.8-1.8-1.81.81.8-1.81.8-2.0
Reaction time false alarm rate0.10.20.30.6-0.4-0.60.40.5-0.40.5-0.4-0.4-0.40.40.4-0.40.3-0.5
Reaction time premature initiation rate1.41.92.5-1.51.61.4-1.5-1.41.5-1.41.31.41.4-1.3-1.41.4-1.21.1
Reaction time premature initiations2.13.04.1-1.92.01.8-2.0-1.71.9-1.71.61.71.7-1.7-1.71.7-1.51.4
Std. dev. reaction times0.10.10.3-0.10.30.2-0.3-0.20.3-0.30.40.40.4-0.4-0.40.4-0.50.2
Reaction time trials completed0.40.60.9-0.91.00.8-0.9-0.80.9-0.70.70.70.7-0.8-0.70.7-0.70.6
Reaction time trials AUC0.40.60.9-0.80.90.8-0.9-0.70.9-0.70.60.70.7-0.8-0.70.7-0.70.6
Run reversals in cocaine runway, females4.44.24.52.1-2.1-2.12.12.1-2.12.1-2.1-2.1-2.02.12.0-2.02.0-2.0
Run reversals in cocaine runway, males2.42.32.4-1.51.51.5-1.5-1.51.5-1.51.51.51.5-1.5-1.51.5-1.51.5
Latency to leave start box in cocaine runway0.60.70.7-0.80.80.8-0.8-0.80.8-0.90.90.80.8-0.8-0.80.8-0.80.8
Latency to leave start box in cocaine runway, F1.51.61.7-1.31.21.3-1.2-1.31.2-1.31.31.31.2-1.3-1.21.2-1.31.3
Latency to leave start box in cocaine runway, M1.31.21.31.1-1.2-1.11.11.1-1.11.1-1.0-1.1-1.11.11.1-1.11.1-1.1
Std. dev. time between licks in bursts1.82.23.31.8-1.7-1.71.61.7-1.61.5-1.4-1.3-1.31.31.3-1.31.1-1.3
Total sessions with >9 infusions0.00.00.10.00.0-0.0-0.00.1-0.00.1-0.2-0.1-0.10.10.1-0.10.2-0.2
Short access day 1 total inactive lever presses0.50.60.60.7-0.7-0.70.70.7-0.70.8-0.8-0.8-0.80.80.8-0.80.8-0.8
Short access day 10 total inactive lever presses0.40.40.50.6-0.6-0.60.60.6-0.60.6-0.6-0.6-0.60.60.6-0.60.7-0.7
Short access day 1 total infusions0.10.20.4-0.50.60.5-0.5-0.40.5-0.30.20.30.3-0.3-0.30.3-0.10.2
Short access day 10 total infusions0.00.00.10.3-0.3-0.20.30.2-0.20.2-0.2-0.2-0.20.20.2-0.20.1-0.1
Short access total infusions0.20.20.30.4-0.4-0.50.40.5-0.40.5-0.5-0.5-0.50.50.5-0.50.5-0.5
Short access day 1 locomotion0.20.20.3-0.40.40.4-0.4-0.40.4-0.50.50.50.5-0.5-0.50.5-0.50.5
Short access day 10 total locomotion0.60.70.80.9-0.9-0.80.90.8-0.90.8-0.7-0.8-0.80.80.8-0.80.7-0.7
Short access total locomotion0.80.81.01.0-1.0-0.91.00.9-1.00.9-0.8-0.9-0.90.90.9-0.90.8-0.8
One hour access (0.3 mA shock)0.30.30.30.6-0.6-0.60.60.6-0.60.5-0.5-0.5-0.50.50.5-0.50.5-0.5
Compulsive drug intake0.00.00.10.0-0.10.00.1-0.0-0.0-0.20.30.10.1-0.1-0.10.1-0.20.2
One hour access (shock baseline)0.00.00.0-0.10.10.1-0.1-0.00.0-0.0-0.00.00.0-0.0-0.00.00.0-0.0
Social response proportion0.20.20.6-0.80.70.7-0.6-0.70.6-0.40.20.30.3-0.3-0.30.3-0.00.4
Social responses1.01.31.61.0-1.1-1.01.11.0-1.11.1-1.2-1.2-1.21.21.2-1.21.3-1.1
Social time0.40.60.90.9-0.9-0.90.80.9-0.80.8-0.7-0.6-0.60.70.6-0.60.5-0.7
Soleus weight1.13.34.1-2.01.82.0-1.8-2.01.8-1.91.81.71.7-1.7-1.71.7-1.61.9
Bone: stiffness0.61.01.1-1.01.01.0-1.0-1.01.0-1.01.01.01.0-0.9-1.01.0-0.91.0
Tibialis anterior weight8.428.730.4-5.45.25.5-5.2-5.55.2-5.55.55.35.3-5.3-5.35.3-5.35.5
Time to tail flick, vehicle, before self-admin0.90.90.91.0-1.0-1.00.91.0-0.91.0-1.0-0.9-0.90.81.0-1.00.9-0.9
Time to tail flick, vehicle, after self-admin2.12.22.8-1.61.71.6-1.6-1.51.6-1.51.41.41.4-1.4-1.51.5-1.21.3
Time to tail flick, test, before self-admin1.01.01.31.1-1.1-1.11.11.0-1.11.0-0.9-1.0-1.01.01.0-1.00.9-0.9
Time to tail flick, test, after self-admin3.13.23.91.7-1.6-1.71.61.8-1.71.9-2.0-1.8-1.81.81.8-1.82.0-1.9
Delta time to tail flick, vehicle, before/after SA0.40.40.7-0.80.80.7-0.8-0.70.7-0.60.60.60.6-0.5-0.70.7-0.40.5
Delta time to tail flick, test, before/after SA0.20.20.50.2-0.1-0.30.20.3-0.20.5-0.7-0.5-0.50.40.5-0.50.7-0.6
Tibia length1.44.16.12.5-2.4-2.32.32.2-2.22.0-1.9-1.8-1.81.81.8-1.81.5-1.7
Ambulatory time before self-admin0.50.50.8-0.60.50.7-0.6-0.70.6-0.80.90.80.8-0.8-0.80.8-0.90.9
Ambulatory time after self-admin3.84.24.4-2.12.12.1-2.1-2.12.1-2.12.12.02.0-2.0-2.02.0-2.02.0
Bone: tissue strength0.10.10.10.4-0.4-0.30.30.3-0.30.3-0.3-0.2-0.20.30.2-0.20.2-0.2
Total heroin consumption0.30.40.5-0.50.50.6-0.5-0.60.5-0.60.70.60.6-0.7-0.70.7-0.70.7
Bone: trabecular number2.54.04.22.1-2.0-2.02.02.0-2.02.0-2.0-2.0-2.02.02.0-2.01.9-1.9
Bone: trabecular spacing2.33.03.2-1.71.81.7-1.8-1.71.8-1.71.71.81.8-1.7-1.81.8-1.71.6
Bone: trabecular thickness1.31.51.81.3-1.3-1.21.31.2-1.31.2-1.2-1.2-1.21.21.2-1.21.2-1.1
Bone: trabecular tissue density1.21.61.8-1.21.21.2-1.3-1.21.3-1.31.31.41.4-1.3-1.41.4-1.41.2
Water consumed over 24 hours1.31.61.7-1.21.21.2-1.2-1.21.2-1.31.31.31.3-1.3-1.31.3-1.31.3
Number of responses in last shaping day0.00.00.00.1-0.1-0.00.00.0-0.0-0.00.10.00.0-0.0-0.00.0-0.10.1