Hub : Genes

Bmp1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 RMTg gene expression Bmp1 0.51 0.2 1.1e-03 0.08 0.06 0.07 0.06 3.5e-03 8.9e-03 5.6e-03 1.2e-02
2 Liver alternative TSS XM_039093690.2 0.07 0.05 3.5e-08 0.06 0.06 0.06 0.06 1.7e-07 1.0e-07 2.1e-07 1.8e-07
3 Adipose gene expression Bmp1 0.09 0.06 1.6e-11 0.1 0.1 0.1 0.1 9.7e-11 5.5e-11 1.1e-10 1.2e-10
4 NAcc gene expression Bmp1 0.04 0.03 1.2e-06 0.04 0.04 0.04 0.04 2.9e-06 3.2e-06 4.2e-06 3.4e-06
5 Brain gene expression Bmp1 0.26 0.14 0.0e+00 0.33 0.33 0.33 0.33 4.9e-32 1.0e-31 2.2e-31 1.2e-31
6 Liver alternative TSS XM_039093690.2 0.06 0.04 6.1e-08 0.06 0.06 0.05 0.06 1.7e-07 1.9e-07 1.2e-06 2.5e-07
7 RMTg intron excision ratio chr15_51964610_51966075 0.1 0.08 7.2e-03 0.06 0.04 0.05 0.05 9.9e-03 2.4e-02 1.6e-02 1.8e-02
8 Liver alternative TSS NM_031323.1 0.05 0.04 1.8e-07 0.06 0.06 0.05 0.06 5.3e-07 6.8e-07 1.2e-06 7.7e-07
9 Liver isoform ratio NM_031323.1 0.04 0.03 1.9e-05 0.04 0.04 0.04 0.04 2.0e-05 2.0e-05 4.8e-05 4.0e-05
10 Liver gene expression Bmp1 0.12 0.08 0.0e+00 0.16 0.15 0.15 0.15 6.3e-17 3.0e-16 5.8e-16 2.3e-16
11 Liver alternative TSS NM_031323.1 0.06 0.04 2.6e-07 0.06 0.05 0.05 0.05 5.9e-07 1.2e-06 1.4e-06 1.8e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density1.01.82.2-0.1-1.51.51.4-1.4-1.4-1.41.41.4-1.31.3
Area under the delay curve0.10.10.80.90.1-0.1-0.20.20.20.2-0.2-0.20.3-0.3
BMI with tail0.41.52.1-1.21.5-1.4-1.21.11.11.2-1.2-1.21.1-1.1
BMI without tail0.10.43.5-1.90.3-0.30.1-0.1-0.1-0.10.10.1-0.30.3
Body weight0.62.43.00.31.7-1.7-1.61.61.61.7-1.6-1.61.6-1.6
Weight adjusted by age1.42.02.40.81.4-1.4-1.51.51.51.5-1.5-1.51.5-1.5
Bone surface0.50.91.40.7-1.21.21.0-1.0-1.0-1.01.01.0-0.70.7
Bone volume0.61.11.50.6-1.21.21.1-1.1-1.1-1.11.11.1-0.90.9
Breakpoint value in progressive ratio session0.10.10.10.30.2-0.2-0.30.30.30.3-0.3-0.30.3-0.3
Number of licking bursts0.00.00.1-0.30.0-0.00.1-0.1-0.1-0.10.10.1-0.10.1
Context. condit. distance diff. score1.72.011.9-3.4-0.50.51.1-1.1-1.1-1.11.11.1-1.21.2
Locomotion velocity, session 10.20.20.20.30.4-0.4-0.50.50.50.4-0.5-0.50.5-0.5
Locomotion distance, session 10.20.32.31.5-0.50.40.2-0.2-0.2-0.20.20.2-0.30.3
Locomotion velocity, session 20.10.10.80.9-0.30.30.1-0.1-0.1-0.20.10.1-0.20.2
Locomotion distance, session 20.50.66.22.5-0.60.60.1-0.1-0.1-0.10.10.1-0.20.2
Locomotion velocity, session 30.70.82.2-1.51.0-1.0-0.70.70.70.7-0.7-0.70.8-0.8
Locomotion distance, session 30.20.21.8-1.30.0-0.00.2-0.2-0.2-0.20.20.2-0.10.1
Stereotopy head waving bouts, day 30.60.70.80.40.9-0.9-0.90.90.90.9-0.9-0.90.8-0.8
Stereotopy head waving duration, day 32.22.62.90.91.6-1.6-1.71.71.71.7-1.7-1.71.6-1.6
Locomotion velocity, session 74.65.014.9-3.9-1.51.62.1-2.1-2.1-2.12.12.1-2.12.1
Locomotion distance, session 73.34.210.1-3.2-1.61.62.0-2.0-2.0-2.02.02.0-2.02.0
Stereotopy head waving bouts, day 71.51.71.91.21.2-1.2-1.41.41.41.4-1.4-1.41.4-1.4
Stereotopy head waving duration, day 72.12.53.01.11.5-1.5-1.61.61.61.6-1.6-1.61.7-1.7
Locomotion velocity, session 80.10.11.4-1.20.1-0.1-0.00.00.0-0.0-0.0-0.0-0.00.0
Locomotion distance, session 80.60.91.4-0.7-0.90.90.9-0.9-0.9-1.00.90.9-1.21.2
Degree of sensitization distance4.04.24.5-2.0-1.91.92.1-2.1-2.1-2.12.12.1-2.12.1
Degree of sensitization stereotypy1.11.21.30.71.1-1.1-1.11.11.11.1-1.1-1.11.1-1.1
Conditioned locomotion0.10.11.0-1.0-0.00.00.2-0.2-0.2-0.20.20.2-0.20.2
Cocaine response after cond. corrected0.60.73.4-1.80.9-0.9-0.60.60.60.6-0.6-0.60.5-0.5
Cocaine response after cond. not corrected0.30.41.7-1.30.7-0.6-0.40.40.40.4-0.4-0.40.4-0.4
Cocaine response before conditioning0.40.52.51.6-0.70.70.4-0.4-0.4-0.40.40.4-0.50.5
Saline control response0.20.31.51.2-0.60.60.3-0.3-0.3-0.30.30.3-0.20.2
Bone: connectivity density2.13.33.7-0.5-1.91.91.9-1.9-1.9-1.91.91.9-1.91.9
Bone: cortical apparent density0.40.54.8-2.20.1-0.00.3-0.3-0.3-0.30.30.3-0.30.3
Bone: cortical area0.10.10.90.9-0.20.2-0.00.00.00.0-0.0-0.00.1-0.1
Bone: cortical porosity1.31.43.01.70.9-0.9-1.11.11.11.1-1.1-1.11.1-1.1
Bone: cortical porosity0.80.93.61.90.6-0.6-0.90.90.90.9-0.9-0.90.8-0.8
Bone: cortical thickness0.00.00.10.2-0.10.10.0-0.0-0.0-0.00.00.00.1-0.1
Bone: cortical thickness0.20.21.7-1.30.2-0.20.0-0.0-0.0-0.00.00.0-0.30.3
Bone: cortical tissue density0.40.65.5-2.30.1-0.00.3-0.3-0.3-0.30.30.3-0.40.4
Condit. Reinf. active minus inactive responses0.50.51.21.10.5-0.5-0.70.70.70.7-0.7-0.70.6-0.6
Condit. Reinf. active-inactive response ratio2.02.12.5-0.11.6-1.6-1.61.61.61.5-1.6-1.61.4-1.4
Condit. Reinf. active responses0.20.22.61.6-0.30.3-0.00.00.00.0-0.0-0.0-0.00.0
Condit. Reinf. inactive responses2.73.34.51.8-2.12.11.7-1.7-1.7-1.71.71.7-1.71.7
Incentive salience index mean0.81.03.92.00.6-0.6-1.01.01.00.9-1.0-1.00.8-0.8
Condit. Reinf. lever presses0.50.74.92.20.2-0.3-0.70.70.70.6-0.7-0.70.4-0.4
Condit. Reinf. active minus inactive responses0.30.40.4-0.1-0.70.70.7-0.7-0.7-0.70.70.7-0.60.6
Condit. Reinf. active-inactive response ratio0.10.10.3-0.50.4-0.3-0.20.20.20.2-0.2-0.20.3-0.3
Condit. Reinf. active responses0.81.11.3-0.1-1.11.11.1-1.1-1.1-1.11.11.1-1.11.1
Condit. Reinf. inactive responses1.82.42.90.3-1.71.71.6-1.6-1.6-1.61.61.6-1.71.7
Condit. Reinf. lever presses0.30.52.41.6-0.70.70.5-0.5-0.5-0.50.50.5-0.60.6
Condit. Reinf. lever reinforcers received0.60.81.00.1-1.01.01.0-1.0-1.0-1.01.01.0-0.90.9
Conditioned reinforcement - actives0.91.61.8-1.0-1.21.21.3-1.3-1.3-1.31.31.3-1.31.3
Conditioned reinforcement - inactives3.04.35.70.7-2.42.42.1-2.1-2.1-2.12.12.1-2.12.1
Conditioned locomotion0.10.20.2-0.5-0.40.40.4-0.4-0.4-0.40.40.4-0.40.4
Patch foraging indifference point 0 sec1.83.46.32.5-2.32.21.7-1.7-1.7-1.81.71.7-1.21.2
Patch foraging indifference point AUC0.20.30.8-0.90.7-0.7-0.50.50.50.5-0.5-0.50.5-0.5
Delay disc. indifference point, 0s delay0.60.72.51.6-0.90.90.6-0.7-0.7-0.60.60.6-0.50.5
Delay disc. indifference point, 16s delay0.20.30.30.3-0.60.60.5-0.5-0.5-0.50.50.5-0.50.5
Delay disc. indifference point, 2s delay1.41.62.81.71.1-1.1-1.31.21.21.3-1.3-1.31.3-1.3
Delay disc. indifference point, 24s delay0.10.20.3-0.50.5-0.5-0.40.30.30.4-0.4-0.40.3-0.3
Delay disc. indifference point, 4s delay1.61.61.80.61.3-1.3-1.31.31.31.3-1.3-1.31.3-1.3
Delay disc. indifference point, 8s delay0.10.10.40.6-0.30.30.2-0.2-0.2-0.20.20.2-0.20.2
Indifference point function ln k0.10.21.61.3-0.30.3-0.00.00.00.0-0.0-0.0-0.20.2
Indifference point function log k0.10.21.61.3-0.30.3-0.00.00.00.0-0.0-0.0-0.20.2
Patch foraging total patch changes 0 sec1.42.76.62.6-2.02.01.5-1.5-1.5-1.51.51.5-1.01.0
Patch foraging total patch changes 12 sec0.81.02.41.6-1.21.20.9-0.9-0.9-1.00.90.9-0.50.5
Patch foraging total patch changes 18 sec1.31.92.50.2-1.61.61.5-1.5-1.5-1.51.51.5-1.21.2
Patch foraging total patch changes 24 sec0.20.43.51.9-0.30.30.0-0.0-0.0-0.00.00.00.3-0.3
Patch foraging total patch changes 6 sec0.20.30.40.4-0.70.60.6-0.6-0.6-0.60.60.6-0.30.3
Patch foraging time to switch 0 sec0.51.01.1-0.6-1.01.01.0-1.0-1.0-1.11.01.0-1.11.1
Patch foraging water rate 0 sec0.30.61.11.10.6-0.6-0.70.70.70.8-0.7-0.70.7-0.7
Patch foraging water rate 12 sec0.51.01.11.00.9-0.9-1.01.01.01.0-1.0-1.01.0-1.0
Patch foraging water rate 18 sec2.64.04.7-0.02.2-2.2-2.12.12.12.1-2.1-2.12.0-2.0
Patch foraging water rate 24 sec0.20.30.9-0.90.7-0.7-0.50.50.50.5-0.5-0.50.3-0.3
Patch foraging water rate 6 sec2.02.94.22.01.4-1.4-1.71.71.71.7-1.7-1.71.8-1.8
Seeking ratio, delayed vs. immediate footshock0.81.01.20.3-1.11.11.0-1.0-1.0-1.01.01.0-1.01.0
Distance traveled before self-admin0.91.23.82.00.7-0.7-1.01.01.01.0-1.0-1.01.1-1.1
Distance traveled after self-admin2.32.93.40.01.9-1.8-1.81.71.71.8-1.8-1.81.7-1.7
Extensor digitorum longus weight11.846.351.11.87.1-7.1-7.17.17.17.2-7.1-7.17.0-7.0
Bone: elastic displacement0.50.61.11.0-0.90.90.7-0.7-0.7-0.70.70.7-0.80.8
Bone: elastic work0.60.74.42.1-0.90.90.5-0.5-0.5-0.50.50.5-0.50.5
Bone: endosteal estimation0.10.21.01.00.2-0.2-0.40.40.40.4-0.4-0.40.5-0.5
Bone: endosteal perimeter0.10.32.21.50.0-0.0-0.30.30.30.3-0.3-0.30.4-0.4
Epididymis fat weight0.82.63.5-0.8-1.61.61.6-1.7-1.7-1.61.61.6-1.91.9
Delta time in closed arm before/after self-admin3.93.74.70.7-2.22.22.0-1.9-1.9-1.92.02.0-1.91.9
Delta time in open arm before/after self-admin0.10.10.1-0.20.3-0.3-0.30.30.30.2-0.3-0.30.2-0.2
Diff in mean of infusions in LGA sessions0.81.01.10.51.0-1.0-1.11.11.11.0-1.1-1.11.0-1.0
Delay discount exponential model param0.40.40.9-1.0-0.50.50.6-0.6-0.6-0.60.60.6-0.60.6
Extinction: sum of active levers before priming2.02.22.7-0.1-1.61.61.5-1.6-1.6-1.51.51.5-1.51.5
Active lever presses in extinction session 60.70.60.8-0.9-0.70.70.8-0.7-0.7-0.80.80.8-0.90.9
Bone: final force0.10.20.40.60.3-0.3-0.40.40.40.4-0.4-0.40.5-0.5
Bone: final moment0.10.21.11.10.2-0.2-0.40.40.40.4-0.4-0.40.4-0.4
Food consumed during 24 hour testing period0.40.51.31.1-0.80.80.6-0.6-0.6-0.60.60.6-0.70.7
Glucose0.10.11.3-1.10.2-0.20.0-0.0-0.0-0.00.00.00.1-0.1
Heart weight0.30.50.80.5-0.90.90.7-0.7-0.7-0.80.70.7-0.50.5
Delay discount hyperbolic model param0.40.51.0-1.0-0.60.60.7-0.7-0.7-0.70.70.7-0.70.7
Intermittent access intake day 1-15 change1.53.23.5-0.5-1.91.91.9-1.9-1.9-1.91.91.9-1.91.9
Intermittent access intake escalation1.63.33.9-0.1-2.02.01.9-1.9-1.9-1.91.91.9-1.91.9
Intermittent access intake escalation 21.31.51.7-0.7-1.21.21.3-1.3-1.3-1.31.31.3-1.31.3
Intermitt. access day 1 inactive lever presses0.00.00.2-0.4-0.00.10.1-0.1-0.1-0.10.10.1-0.10.1
Intermitt. access day 15 inactive lever presses0.00.10.20.4-0.30.30.2-0.2-0.2-0.20.20.2-0.20.2
Intermitt. access escalation Index0.10.10.50.70.1-0.1-0.20.20.20.2-0.2-0.20.2-0.2
Intermittent access day 1 total infusions0.00.00.00.20.0-0.0-0.00.00.00.0-0.0-0.00.0-0.0
Intermittent access day 15 total infusions1.52.32.90.2-1.71.71.6-1.6-1.6-1.61.61.6-1.61.6
Intermittent access terminal intake (last 3 days)1.01.31.4-0.6-1.11.11.2-1.2-1.2-1.21.21.2-1.21.2
Intermittent access total infusions1.11.31.5-0.6-1.21.21.2-1.2-1.2-1.21.21.2-1.21.2
Intermittent access day 1 locomotion0.10.10.90.9-0.30.20.1-0.1-0.1-0.10.10.1-0.00.0
Intermittent access day 15 total locomotion0.20.40.5-0.5-0.60.60.6-0.6-0.6-0.60.60.6-0.70.7
Intermittent access total locomotion0.10.10.1-0.0-0.40.40.3-0.3-0.3-0.30.30.3-0.40.4
Intermittent access standard deviation0.10.30.40.3-0.60.60.5-0.5-0.5-0.50.50.5-0.50.5
Left kidney weight0.10.31.31.20.2-0.3-0.40.40.40.4-0.4-0.40.4-0.4
Right kidney weight0.10.65.02.2-0.10.1-0.20.20.20.3-0.2-0.20.7-0.7
Cocaine induced anxiety0.40.55.32.3-0.40.3-0.00.00.00.0-0.0-0.00.2-0.2
Post-drug Anxiety1.21.33.31.8-1.31.31.0-1.0-1.0-1.01.01.0-0.90.9
Baseline Anxiety0.50.61.4-1.2-0.50.60.7-0.7-0.7-0.70.70.7-0.80.8
Tail length0.52.02.71.0-1.61.61.4-1.4-1.4-1.41.41.4-1.31.3
Length with tail0.10.53.61.90.1-0.2-0.40.40.40.4-0.4-0.40.6-0.6
Length without tail2.16.98.21.82.5-2.5-2.72.72.72.7-2.7-2.72.9-2.9
Times rat made contact with spout0.50.60.8-0.6-0.70.70.8-0.8-0.8-0.80.80.8-0.90.9
Lifetime Intake0.60.80.9-0.6-0.90.90.9-0.9-0.9-0.90.90.9-0.90.9
Liver weight, left1.72.84.52.11.4-1.4-1.71.71.71.7-1.7-1.71.5-1.5
Liver weight, right0.40.71.0-0.11.0-1.0-0.90.90.90.9-0.9-0.90.6-0.6
Locomotor activity2.53.819.54.40.9-1.0-1.61.71.71.6-1.6-1.61.6-1.6
Locomotor testing distance1.01.716.94.1-0.90.90.2-0.2-0.2-0.20.20.2-0.20.2
Locomotor testing rearing1.22.421.54.6-1.31.20.5-0.4-0.4-0.50.50.5-0.40.4
Locomotion in novel chamber0.40.50.80.4-0.90.90.7-0.7-0.7-0.80.70.7-0.80.8
Locomotion in novel chamber post-restriction0.71.11.30.01.1-1.1-1.11.11.11.1-1.1-1.11.1-1.1
Fecal boli incidents, locomotor time 10.91.31.51.11.0-1.0-1.21.11.11.2-1.2-1.21.2-1.2
Change in fecal boli incidents, locomotor task0.30.30.4-0.70.6-0.6-0.50.50.50.5-0.5-0.50.5-0.5
Time >=10cm from walls, locomotor time 11.01.01.30.1-1.11.11.1-1.0-1.0-1.01.01.0-1.01.0
Bouts of movement, locomotor time 14.34.95.9-0.22.4-2.4-2.32.42.42.3-2.3-2.32.2-2.2
Total resting periods, locomotor time 14.34.86.0-0.72.5-2.4-2.32.32.32.2-2.2-2.22.2-2.2
Rest time, locomotor task time 11.72.12.8-0.61.7-1.7-1.51.51.51.4-1.4-1.41.5-1.5
Distance moved, locomotor task time 12.13.13.6-0.3-1.91.91.9-1.7-1.7-1.91.91.9-1.91.9
Vertical activity count, locomotor time 10.51.31.81.3-1.31.31.1-1.0-1.0-1.11.11.1-0.90.9
Time >=10cm from walls, locomotor time 20.30.50.6-0.10.7-0.7-0.70.70.70.7-0.7-0.70.7-0.7
Bouts of movement, locomotor time 23.04.75.70.02.4-2.4-2.32.32.32.2-2.2-2.22.2-2.2
Total resting periods, locomotor time 22.95.16.3-0.02.5-2.5-2.42.42.42.3-2.3-2.32.3-2.3
Rest time, locomotor task time 20.91.21.9-1.01.4-1.4-1.11.11.11.0-1.0-1.01.0-1.0
Distance moved, locomotor task time 22.93.44.60.8-2.22.11.9-1.8-1.8-1.91.91.9-1.81.8
Vertical activity count, locomotor time 20.50.71.81.3-1.01.00.8-0.7-0.7-0.70.70.7-0.60.6
Light reinforcement 12.05.06.5-1.4-2.12.12.3-2.3-2.3-2.22.32.3-2.52.5
Light reinforcement 21.21.97.5-2.7-0.70.71.2-1.3-1.3-1.11.21.2-1.31.3
Bone: marrow area0.10.11.01.00.1-0.1-0.20.20.20.2-0.2-0.20.4-0.4
Bone: maximum diameter0.40.71.00.30.8-0.8-0.80.80.80.8-0.8-0.81.0-1.0
Bone: maximum force0.30.61.61.30.5-0.5-0.70.70.70.7-0.7-0.70.9-0.9
Bone: maximum moment0.30.63.01.70.2-0.3-0.60.60.60.6-0.6-0.60.7-0.7
Mean time between licks in bursts1.12.84.10.3-1.81.71.7-1.7-1.7-1.71.71.7-2.02.0
Mean num. licks in bursts0.20.30.3-0.2-0.60.60.5-0.5-0.5-0.50.50.5-0.60.6
Cd content in liver1.11.21.61.30.9-0.9-1.11.11.11.1-1.1-1.11.2-1.2
Co content in liver4.85.56.6-0.52.6-2.6-2.42.42.42.4-2.4-2.42.5-2.5
Cu content in liver0.40.50.6-0.20.7-0.7-0.70.70.70.7-0.7-0.70.8-0.8
Fe content in liver1.31.62.0-0.1-1.41.41.4-1.4-1.4-1.41.41.4-1.11.1
K content in liver1.01.01.1-0.7-1.01.01.1-1.1-1.1-1.11.11.1-1.01.0
Mg content in liver2.42.52.7-0.7-1.61.61.7-1.7-1.7-1.71.71.7-1.61.6
Mn content in liver2.32.63.10.0-1.81.71.7-1.7-1.7-1.71.71.7-1.61.6
Na content in liver1.41.57.72.80.6-0.6-1.01.01.01.0-1.0-1.01.1-1.1
Rb content in liver0.10.11.3-1.10.0-0.00.1-0.1-0.1-0.10.10.1-0.00.0
Se content in liver1.61.86.82.6-1.61.51.0-1.0-1.0-1.01.01.0-1.01.0
Sr content in liver0.10.00.20.5-0.30.30.2-0.2-0.2-0.20.20.20.0-0.0
Zn content in liver0.30.31.31.1-0.60.60.4-0.4-0.4-0.40.40.4-0.20.2
Bone: minimum diameter0.30.52.91.70.2-0.2-0.50.50.50.5-0.5-0.50.7-0.7
Time in familiar zone, hab. session 10.10.10.4-0.60.3-0.3-0.20.20.20.2-0.2-0.20.2-0.2
Time in novel zone, hab. session 11.11.11.5-0.41.2-1.2-1.11.11.11.1-1.1-1.11.1-1.1
Total zone transitions, hab. session 10.20.31.61.30.2-0.3-0.50.50.50.5-0.5-0.50.4-0.4
Total locomotion distance, hab. session 10.20.32.61.6-0.40.40.1-0.1-0.1-0.10.10.1-0.10.1
Locomotion velocity, hab. session 10.50.75.32.3-0.80.80.4-0.4-0.4-0.40.40.4-0.40.4
Time in familiar zone, hab. session 22.22.43.1-1.51.8-1.7-1.51.51.51.5-1.5-1.51.4-1.4
Time in novel zone, hab. session 20.80.81.11.0-1.11.00.9-0.9-0.9-0.90.90.9-0.80.8
Total zone transitions, hab. session 21.41.74.72.21.0-1.0-1.31.31.31.3-1.3-1.31.1-1.1
Total locomotion distance, hab. session 20.30.42.41.60.3-0.3-0.50.50.50.5-0.5-0.50.4-0.4
Locomotion velocity, hab. session 20.70.94.02.00.5-0.5-0.80.80.80.8-0.8-0.80.7-0.7
Novel to familiar place preference ratio1.51.62.00.5-1.41.41.3-1.3-1.3-1.31.31.3-1.31.3
Novelty place preference1.21.31.60.5-1.31.31.2-1.2-1.2-1.11.21.2-1.11.1
Time in novel zone, NPP test0.60.70.90.5-0.90.90.9-0.9-0.9-0.80.90.9-0.80.8
Total zone transitions, NPP test0.30.52.11.5-0.80.80.5-0.5-0.5-0.50.50.5-0.60.6
Total locomotion distance, NPP test2.83.85.11.4-2.32.21.9-1.9-1.9-1.91.91.9-2.02.0
Locomotion velocity, NPP test2.63.74.91.3-2.22.21.9-1.9-1.9-1.91.91.9-2.02.0
Intraocular pressure0.60.81.50.2-0.90.90.9-0.9-0.9-0.80.90.9-1.21.2
Delta distance traveled before/after self-admin3.13.34.7-1.82.2-2.1-1.81.81.81.8-1.8-1.81.6-1.6
Delta ambulatory time before/after self-admin2.83.54.8-1.52.2-2.2-1.81.81.81.9-1.8-1.81.7-1.7
Parametrial fat weight1.63.84.5-0.5-2.12.12.1-2.1-2.1-2.02.12.1-1.91.9
Pavlov. Cond. lever latency0.10.11.1-1.00.2-0.20.0-0.0-0.0-0.00.00.00.1-0.1
Pavlov. Cond. magazine entry latency0.00.00.00.1-0.20.20.2-0.2-0.2-0.20.20.2-0.20.2
Pavlov. Cond. change in total contacts1.11.22.11.40.9-0.9-1.11.11.11.1-1.1-1.10.9-0.9
Pavlov. Cond. index score0.10.10.80.90.1-0.1-0.30.30.30.3-0.3-0.30.2-0.2
Pavlov. Cond. latency score0.10.10.90.9-0.00.0-0.20.20.20.2-0.2-0.20.1-0.1
Pavlov. Cond. lever contacts0.10.10.90.9-0.30.30.1-0.1-0.1-0.10.10.1-0.20.2
Pavlov. Cond. magazine entry number0.30.40.5-0.5-0.60.60.7-0.7-0.7-0.70.70.7-0.60.6
Pavlov. Cond. intertrial magazine entries0.30.31.91.4-0.60.60.4-0.4-0.4-0.40.40.4-0.20.2
Pavlov. Cond. lever-magazine prob. diff.0.20.30.90.90.3-0.3-0.50.50.50.5-0.5-0.50.4-0.4
Pavlov. Cond. response bias0.10.20.20.50.3-0.4-0.50.50.50.4-0.5-0.50.3-0.3
Pavlov. Cond. lever latency0.60.85.1-2.3-0.40.40.7-0.7-0.7-0.70.70.7-0.60.6
Pavlov. Cond. magazine entry latency0.20.31.81.3-0.50.50.3-0.3-0.3-0.30.30.3-0.30.3
Pavlov. Cond. change in total contacts1.11.73.21.81.1-1.1-1.31.31.31.3-1.3-1.31.2-1.2
Pavlov. Cond. index score0.60.74.72.20.4-0.4-0.60.60.60.6-0.6-0.60.6-0.6
Pavlov. Cond. latency score0.50.64.72.20.2-0.2-0.50.50.50.5-0.5-0.50.4-0.4
Pavlov. Cond. lever contacts0.40.64.92.20.1-0.1-0.40.40.40.4-0.4-0.40.3-0.3
Pavlov. Cond. magazine entry number0.10.21.1-1.00.4-0.4-0.20.20.20.2-0.2-0.20.3-0.3
Pavlov. Cond. intertrial magazine entries4.77.18.2-0.6-2.82.82.8-2.8-2.8-2.82.82.8-2.92.9
Pavlov. Cond. lever-magazine prob. diff.0.60.84.12.00.5-0.5-0.70.70.70.7-0.7-0.70.6-0.6
Pavlov. Cond. response bias0.50.65.42.30.1-0.2-0.50.50.50.5-0.5-0.50.4-0.4
Time in closed arm before self-admin1.52.02.6-0.61.6-1.6-1.51.41.41.4-1.5-1.51.4-1.4
Time in closed arm after self-admin0.00.00.0-0.10.2-0.2-0.20.20.20.2-0.2-0.20.2-0.2
Time in open arm before self-admin0.00.00.50.7-0.20.20.1-0.1-0.1-0.00.10.10.0-0.0
Time in open arm after self-admin0.10.10.30.5-0.30.30.2-0.2-0.2-0.20.20.2-0.20.2
Bone: periosteal estimation0.10.21.21.10.1-0.1-0.30.30.30.3-0.3-0.30.5-0.5
Bone: periosteal perimeter0.10.11.01.00.1-0.1-0.20.20.20.2-0.2-0.20.4-0.4
Bone: post-yield work0.20.31.2-1.1-0.30.30.4-0.4-0.4-0.40.40.4-0.50.5
Progressive ratio test 1 active lever presses0.20.31.5-1.20.5-0.5-0.30.30.30.3-0.3-0.30.2-0.2
Progressive ratio test 1 breakpoint0.30.31.5-1.20.6-0.6-0.40.40.40.4-0.4-0.40.3-0.3
Progressive ratio test 1 inactive lever presses0.81.11.2-0.9-1.01.01.1-1.1-1.1-1.11.11.1-1.11.1
Progressive ratio test 2 active lever presses0.10.10.9-0.9-0.00.00.2-0.2-0.2-0.20.20.2-0.20.2
Progressive ratio test 2 breakpoint0.10.10.5-0.7-0.00.10.1-0.1-0.1-0.10.10.1-0.20.2
Progressive ratio test 2 inactive lever presses0.20.40.4-0.4-0.60.60.6-0.6-0.6-0.60.60.6-0.70.7
Incentive Sensitization - Responses0.20.30.4-0.1-0.60.60.6-0.6-0.6-0.60.60.6-0.60.6
Incentive Sensitization - Breakpoint0.30.40.50.1-0.70.70.7-0.7-0.7-0.70.70.7-0.70.7
Sum of active levers in priming session hrs 5-60.20.20.9-0.9-0.20.20.3-0.3-0.3-0.30.30.3-0.40.4
Progressive ratio0.00.00.2-0.50.2-0.2-0.10.10.10.1-0.1-0.10.1-0.1
Food seeking constrained by brief footshock2.83.48.5-2.92.2-2.2-1.61.61.61.6-1.6-1.61.4-1.4
Seeking ratio, punishment vs. effort0.81.11.6-1.11.3-1.2-1.01.01.01.0-1.0-1.00.9-0.9
Retroperitoneal fat weight0.10.41.2-1.1-0.50.50.7-0.7-0.7-0.60.70.7-0.30.3
Reaction time number correct0.50.91.4-0.61.2-1.2-1.01.01.01.0-1.0-1.00.8-0.8
Reaction time mean minus median0.10.21.11.00.2-0.2-0.40.30.30.3-0.4-0.40.5-0.5
Reaction time mean minus median AUC0.00.10.30.60.2-0.2-0.30.20.20.2-0.3-0.30.3-0.3
Reaction time num false alarms0.10.20.40.60.3-0.3-0.40.40.40.4-0.4-0.40.1-0.1
Reaction time num false alarms AUC0.10.10.20.50.2-0.2-0.30.40.40.3-0.3-0.3-0.00.0
Reaction time trials correct on left0.50.91.4-0.61.2-1.2-1.01.01.01.0-1.0-1.00.8-0.8
Reaction time trials on left0.40.71.1-0.61.0-1.0-0.90.80.80.9-0.9-0.90.6-0.6
Reaction time mean0.10.20.30.60.3-0.4-0.50.50.50.4-0.5-0.50.3-0.3
Reaction time mean AUC0.20.40.60.80.5-0.5-0.60.70.70.6-0.6-0.60.5-0.5
Median of all reaction times0.10.10.20.20.4-0.4-0.40.40.40.4-0.4-0.40.2-0.2
Reaction time omissions1.72.53.0-0.6-1.61.61.6-1.6-1.6-1.61.61.6-1.71.7
Reaction time false alarm rate0.10.10.20.4-0.30.30.2-0.2-0.2-0.30.20.2-0.40.4
Reaction time premature initiation rate1.82.63.4-0.81.8-1.8-1.71.81.81.6-1.7-1.71.3-1.3
Reaction time premature initiations2.13.75.2-1.12.3-2.3-2.02.12.12.0-2.0-2.01.5-1.5
Std. dev. reaction times0.10.20.60.70.3-0.3-0.40.30.30.4-0.4-0.40.3-0.3
Reaction time trials completed0.40.71.1-0.61.0-1.0-0.90.80.80.9-0.9-0.90.6-0.6
Reaction time trials AUC0.30.61.0-0.61.0-1.0-0.90.80.80.9-0.9-0.90.6-0.6
Run reversals in cocaine runway, females3.03.03.5-0.2-1.91.91.8-1.8-1.8-1.71.81.8-1.81.8
Run reversals in cocaine runway, males1.81.82.00.51.4-1.4-1.41.41.41.4-1.4-1.41.4-1.4
Latency to leave start box in cocaine runway0.40.50.60.10.7-0.7-0.70.70.70.8-0.7-0.70.7-0.7
Latency to leave start box in cocaine runway, F1.21.41.70.41.2-1.2-1.21.21.21.3-1.2-1.21.3-1.3
Latency to leave start box in cocaine runway, M0.10.10.10.0-0.30.30.3-0.3-0.3-0.30.30.3-0.30.3
Std. dev. time between licks in bursts1.72.44.52.1-1.71.71.3-1.3-1.3-1.31.31.3-1.71.7
Total sessions with >9 infusions0.00.10.1-0.20.2-0.2-0.20.20.20.2-0.2-0.20.2-0.2
Short access day 1 total inactive lever presses0.20.20.70.9-0.50.50.4-0.4-0.4-0.40.40.4-0.30.3
Short access day 10 total inactive lever presses0.10.20.2-0.2-0.40.40.5-0.5-0.5-0.50.50.5-0.50.5
Short access day 1 total infusions0.10.10.6-0.80.4-0.4-0.30.30.30.3-0.3-0.30.2-0.2
Short access day 10 total infusions0.30.41.01.00.5-0.5-0.60.60.60.6-0.6-0.60.7-0.7
Short access total infusions0.00.10.10.20.2-0.2-0.20.20.20.2-0.2-0.20.2-0.2
Short access day 1 locomotion0.91.11.61.30.8-0.9-1.01.01.01.0-1.0-1.01.1-1.1
Short access day 10 total locomotion0.00.10.70.8-0.10.10.1-0.1-0.1-0.10.10.10.0-0.0
Short access total locomotion0.30.32.11.40.1-0.1-0.40.40.40.4-0.4-0.40.4-0.4
One hour access (0.3 mA shock)0.70.81.10.7-1.01.00.9-0.9-0.9-0.90.90.9-0.80.8
Compulsive drug intake0.70.81.21.1-1.01.00.9-0.9-0.9-0.90.90.9-0.70.7
One hour access (shock baseline)0.00.00.10.3-0.10.1-0.00.00.00.0-0.0-0.0-0.00.0
Social response proportion0.60.75.0-2.20.7-0.7-0.40.40.40.4-0.4-0.40.5-0.5
Social responses0.91.21.4-0.9-1.11.11.2-1.2-1.2-1.21.21.2-0.90.9
Social time0.40.51.81.3-0.90.90.6-0.5-0.5-0.60.60.6-0.50.5
Soleus weight1.13.34.2-0.22.1-2.0-1.91.91.92.0-1.9-1.91.6-1.6
Bone: stiffness0.71.11.50.61.0-1.0-1.11.11.11.1-1.1-1.11.2-1.2
Tibialis anterior weight7.525.528.22.05.2-5.2-5.35.35.35.3-5.3-5.35.3-5.3
Time to tail flick, vehicle, before self-admin0.91.01.1-0.6-1.01.01.0-1.0-1.0-1.11.01.0-1.01.0
Time to tail flick, vehicle, after self-admin1.62.22.9-1.61.7-1.7-1.41.51.51.4-1.4-1.41.3-1.3
Time to tail flick, test, before self-admin2.82.93.70.4-1.91.91.8-1.8-1.8-1.81.81.8-1.71.7
Time to tail flick, test, after self-admin2.52.55.0-2.2-1.21.31.6-1.6-1.6-1.61.61.6-1.61.6
Delta time to tail flick, vehicle, before/after SA0.50.51.6-1.30.8-0.8-0.50.60.60.6-0.5-0.50.5-0.5
Delta time to tail flick, test, before/after SA0.60.66.6-2.60.4-0.30.1-0.1-0.1-0.10.10.1-0.20.2
Tibia length1.54.18.83.0-2.52.41.8-1.8-1.8-1.81.81.8-1.51.5
Ambulatory time before self-admin0.30.52.41.50.3-0.4-0.60.60.60.6-0.6-0.60.6-0.6
Ambulatory time after self-admin4.85.76.30.62.5-2.5-2.52.52.52.5-2.5-2.52.5-2.5
Bone: tissue strength0.00.00.10.3-0.30.30.2-0.2-0.2-0.20.20.2-0.00.0
Total heroin consumption0.60.70.80.90.7-0.7-0.80.90.90.9-0.8-0.80.8-0.8
Bone: trabecular number1.93.23.8-0.1-1.91.91.9-1.9-1.9-1.91.91.9-1.81.8
Bone: trabecular spacing2.12.83.20.21.8-1.8-1.71.71.71.7-1.7-1.71.8-1.8
Bone: trabecular thickness1.11.41.70.4-1.31.31.2-1.2-1.2-1.21.21.2-1.21.2
Bone: trabecular tissue density1.21.81.91.01.3-1.3-1.41.41.41.4-1.4-1.41.4-1.4
Water consumed over 24 hours1.11.51.60.91.2-1.2-1.31.31.31.3-1.3-1.31.3-1.3
Number of responses in last shaping day0.50.60.70.40.7-0.8-0.80.80.80.8-0.8-0.80.8-0.8