Hub : Genes

Naa40

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	mRNA stability	Naa40	0.09	0.05	3.6e-06	0.03	0.04	0.04	0.04	1.2e-04	4.0e-05	2.6e-05	4.6e-05
2	PL	mRNA stability	Naa40	0.07	0.04	1.9e-06	0.03	0.04	0.06	0.04	1.9e-04	2.5e-05	8.1e-07	3.4e-05
3	Adipose	gene expression	Naa40	0.06	0.05	8.0e-04	0.02	0.02	0.01	0.02	1.2e-03	1.9e-03	9.3e-03	1.5e-03
4	Brain	mRNA stability	Naa40	0.11	0.06	3.5e-10	0.1	0.11	0.09	0.1	1.7e-09	2.2e-10	6.9e-09	5.6e-10
5	OFC	intron excision ratio	chr1_213847124_213853227	0.2	0.11	6.3e-03	0.1	0.07	0.06	0.1	2.8e-03	1.0e-02	2.0e-02	2.6e-03
6	OFC	intron excision ratio	chr1_213845371_213846562	0.2	0.11	6.4e-03	0.08	0.06	0.05	0.08	6.6e-03	1.7e-02	2.9e-02	6.0e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	0.3	0.6	1.8	-0.7	-1.4	-1.0	0.0	0.4	-0.4
Area under the delay curve	0.2	0.4	0.8	-0.4	-0.9	-0.5	0.2	-0.7	0.7
BMI with tail	0.9	3.1	7.4	-2.6	-2.7	-1.7	1.1	0.5	-0.5
BMI without tail	0.4	2.2	6.0	-1.9	-2.4	-0.3	1.4	-0.9	0.9
Body weight	1.4	6.1	15.9	-3.7	-4.0	-0.1	2.7	-0.0	0.0
Weight adjusted by age	0.3	1.0	1.8	-1.3	-0.9	1.2	0.8	0.8	-0.8
Bone surface	2.0	4.0	8.6	-2.5	-2.9	-0.4	0.8	2.1	-2.1
Bone volume	1.1	2.2	3.9	-1.1	-1.7	-1.0	-0.2	2.0	-2.0
Breakpoint value in progressive ratio session	1.2	2.2	4.4	-2.1	-2.0	1.0	1.4	1.0	-1.0
Number of licking bursts	0.1	0.2	0.3	-0.5	-0.2	0.3	0.2	0.5	-0.5
Context. condit. distance diff. score	0.7	0.8	1.1	1.1	0.8	-0.9	-0.8	-0.9	0.9
Locomotion velocity, session 1	0.4	0.5	1.1	-0.2	-0.7	-0.2	0.3	-1.0	1.0
Locomotion distance, session 1	0.5	0.7	2.0	-0.5	-1.4	-0.8	0.4	-0.7	0.7
Locomotion velocity, session 2	1.0	1.2	2.8	-1.7	-1.6	0.5	1.3	-0.0	0.0
Locomotion distance, session 2	0.6	0.8	2.0	-0.8	-1.4	-0.1	0.8	-0.8	0.8
Locomotion velocity, session 3	0.9	1.0	4.3	0.7	-0.1	-2.1	-0.6	-0.7	0.7
Locomotion distance, session 3	0.1	0.1	0.2	0.0	-0.2	-0.4	0.1	-0.3	0.3
Stereotopy head waving bouts, day 3	1.2	1.4	4.7	0.8	-0.2	-2.2	-0.9	-1.1	1.1
Stereotopy head waving duration, day 3	0.6	0.8	2.2	1.0	0.4	-1.5	-1.0	-0.3	0.3
Locomotion velocity, session 7	0.7	0.7	2.9	0.8	0.2	-1.7	-0.8	-0.2	0.2
Locomotion distance, session 7	0.4	0.6	1.4	0.0	-0.4	-0.7	0.1	-1.2	1.2
Stereotopy head waving bouts, day 7	0.6	0.7	1.3	0.1	0.4	-1.0	-0.7	1.1	-1.1
Stereotopy head waving duration, day 7	0.5	0.7	1.6	-0.8	-0.3	-0.1	0.2	1.3	-1.3
Locomotion velocity, session 8	1.1	1.3	2.8	-1.3	-1.7	0.5	1.0	-1.1	1.1
Locomotion distance, session 8	0.5	0.7	2.6	0.4	-0.5	-1.6	-0.8	-0.4	0.4
Degree of sensitization distance	0.3	0.3	0.9	0.1	-0.2	-0.9	-0.2	-0.6	0.6
Degree of sensitization stereotypy	0.8	0.8	2.3	-0.5	0.1	-0.3	-0.2	1.5	-1.5
Conditioned locomotion	0.6	0.8	2.0	-1.4	-1.0	0.6	1.1	-0.1	0.1
Cocaine response after cond. corrected	0.8	1.2	2.1	1.1	0.7	-1.0	-0.5	-1.4	1.4
Cocaine response after cond. not corrected	0.5	0.8	1.4	0.9	0.1	-0.9	-0.4	-1.2	1.2
Cocaine response before conditioning	0.6	0.7	1.3	-0.7	-1.0	0.6	0.4	1.1	-1.1
Saline control response	2.8	3.9	7.5	-2.7	-2.5	1.7	2.4	-0.5	0.5
Bone: connectivity density	1.0	1.7	4.9	-1.8	-2.2	-0.3	0.9	0.7	-0.7
Bone: cortical apparent density	0.2	0.4	1.6	-0.3	0.2	1.3	0.6	-0.1	0.1
Bone: cortical area	0.3	0.5	0.8	-0.9	-0.6	0.1	0.5	0.9	-0.9
Bone: cortical porosity	0.1	0.2	0.5	-0.4	-0.7	0.4	0.3	0.1	-0.1
Bone: cortical porosity	0.4	0.5	1.3	-0.8	-1.1	0.6	0.6	0.0	-0.0
Bone: cortical thickness	2.4	4.0	7.8	-2.4	-1.7	2.6	2.8	-0.5	0.5
Bone: cortical thickness	1.4	1.8	2.5	-1.0	-1.2	1.0	1.6	-1.5	1.5
Bone: cortical tissue density	0.3	0.5	2.1	-0.5	0.1	1.4	0.8	-0.1	0.1
Condit. Reinf. active minus inactive responses	0.2	0.2	0.3	-0.6	-0.2	0.5	0.6	-0.3	0.3
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.9	-0.4	0.2	0.9	0.4	-0.1	0.1
Condit. Reinf. active responses	0.0	0.0	0.1	-0.0	0.3	-0.3	-0.0	0.1	-0.1
Condit. Reinf. inactive responses	0.5	0.6	2.1	0.6	0.2	-1.4	-0.9	0.4	-0.4
Incentive salience index mean	0.2	0.2	0.5	-0.7	-0.6	0.0	0.6	-0.2	0.2
Condit. Reinf. lever presses	0.2	0.4	0.7	-0.6	-0.8	-0.5	0.3	0.6	-0.6
Condit. Reinf. active minus inactive responses	0.5	0.7	1.2	0.6	0.1	-0.8	-0.9	1.1	-1.1
Condit. Reinf. active-inactive response ratio	1.7	2.7	4.3	1.5	0.8	-2.0	-2.1	1.6	-1.6
Condit. Reinf. active responses	0.2	0.2	0.7	-0.2	-0.1	-0.1	-0.0	0.8	-0.8
Condit. Reinf. inactive responses	0.8	1.2	2.3	-1.3	-0.9	1.2	1.5	-0.6	0.6
Condit. Reinf. lever presses	1.1	1.5	2.9	-1.3	-1.2	-0.3	0.4	1.7	-1.7
Condit. Reinf. lever reinforcers received	0.3	0.4	0.9	-0.5	-0.3	0.2	0.2	1.0	-1.0
Conditioned reinforcement - actives	0.7	2.7	6.7	0.5	0.6	-0.7	-1.4	2.6	-2.6
Conditioned reinforcement - inactives	1.8	4.8	7.9	2.0	2.8	-1.6	-2.3	2.1	-2.1
Conditioned locomotion	5.5	8.1	18.3	3.6	4.3	-2.1	-3.1	1.2	-1.2
Patch foraging indifference point 0 sec	0.0	0.0	0.0	0.1	-0.2	0.1	0.1	0.1	-0.1
Patch foraging indifference point AUC	0.8	1.9	2.6	-1.6	-1.3	1.6	0.9	1.4	-1.4
Delay disc. indifference point, 0s delay	0.8	0.9	1.8	0.1	-0.9	-1.3	-0.2	-1.1	1.1
Delay disc. indifference point, 16s delay	0.3	0.4	0.7	0.8	0.9	-0.6	-0.7	0.4	-0.4
Delay disc. indifference point, 2s delay	0.3	0.3	1.3	0.2	0.2	-1.1	-0.7	0.1	-0.1
Delay disc. indifference point, 24s delay	0.3	0.5	0.8	-0.3	-0.2	0.8	0.6	-0.9	0.9
Delay disc. indifference point, 4s delay	1.0	1.0	2.0	-0.5	-1.2	-0.3	0.7	-1.4	1.4
Delay disc. indifference point, 8s delay	0.4	0.7	1.4	-0.4	-1.1	-0.3	0.4	-1.2	1.2
Indifference point function ln k	1.8	5.3	8.8	3.0	2.0	-2.1	-1.7	-2.4	2.4
Indifference point function log k	1.8	5.3	8.8	3.0	2.0	-2.1	-1.7	-2.4	2.4
Patch foraging total patch changes 0 sec	0.1	0.2	0.4	-0.1	-0.4	0.6	0.5	-0.4	0.4
Patch foraging total patch changes 12 sec	2.9	3.8	7.2	-2.6	-2.7	1.9	2.2	0.6	-0.6
Patch foraging total patch changes 18 sec	0.3	0.8	1.7	-1.0	-1.3	0.9	0.6	0.7	-0.7
Patch foraging total patch changes 24 sec	0.6	2.2	3.9	-2.0	-1.3	1.8	1.9	0.4	-0.4
Patch foraging total patch changes 6 sec	0.6	1.0	2.1	-1.4	-1.3	0.7	1.2	-0.5	0.5
Patch foraging time to switch 0 sec	0.3	1.2	1.7	-1.1	-1.3	-1.0	-0.0	1.3	-1.3
Patch foraging water rate 0 sec	0.6	2.4	7.0	2.2	2.6	0.1	-0.9	-1.0	1.0
Patch foraging water rate 12 sec	1.5	6.2	15.4	3.0	3.9	-0.4	-1.1	-2.4	2.4
Patch foraging water rate 18 sec	1.0	2.3	3.6	1.6	1.8	-0.8	-0.4	-1.9	1.9
Patch foraging water rate 24 sec	1.6	2.3	4.8	1.8	2.2	-0.6	-0.9	-1.5	1.5
Patch foraging water rate 6 sec	2.4	3.5	6.2	2.1	2.1	-0.2	-0.4	-2.5	2.5
Seeking ratio, delayed vs. immediate footshock	0.1	0.2	0.7	0.4	0.8	-0.1	0.0	-0.3	0.3
Distance traveled before self-admin	0.4	0.9	2.3	-0.6	-0.6	-0.4	0.2	1.5	-1.5
Distance traveled after self-admin	0.2	0.4	0.9	-0.5	0.1	1.0	0.5	0.7	-0.7
Extensor digitorum longus weight	3.5	14.1	31.9	-5.7	-5.1	2.6	4.4	0.3	-0.3
Bone: elastic displacement	1.0	1.3	2.8	0.7	0.9	0.8	0.3	-1.7	1.7
Bone: elastic work	1.9	2.5	3.8	-1.5	-1.2	1.4	2.0	-1.7	1.7
Bone: endosteal estimation	1.3	3.1	10.3	1.4	0.5	-3.2	-2.3	0.5	-0.5
Bone: endosteal perimeter	2.1	5.2	13.6	1.8	0.9	-3.7	-3.0	1.5	-1.5
Epididymis fat weight	1.6	8.3	12.8	3.5	3.2	-3.6	-3.4	1.3	-1.3
Delta time in closed arm before/after self-admin	3.1	2.9	5.0	-0.3	-2.2	0.4	1.5	-2.2	2.2
Delta time in open arm before/after self-admin	1.4	1.6	4.2	-0.6	0.9	0.3	-0.1	2.1	-2.1
Diff in mean of infusions in LGA sessions	0.5	0.9	2.3	-0.9	-1.5	0.7	1.3	-0.1	0.1
Delay discount exponential model param	0.3	0.4	0.8	0.5	0.9	0.3	-0.3	0.7	-0.7
Extinction: sum of active levers before priming	0.9	1.3	2.7	-1.7	-1.6	0.6	1.3	0.6	-0.6
Active lever presses in extinction session 6	2.0	2.0	2.9	-1.7	-1.5	0.7	0.8	1.7	-1.7
Bone: final force	0.9	1.5	3.4	-1.8	-1.9	0.1	1.0	0.8	-0.8
Bone: final moment	0.9	1.4	3.3	-1.8	-1.8	0.1	1.0	0.7	-0.7
Food consumed during 24 hour testing period	0.2	0.5	0.9	0.0	0.9	0.6	-0.3	0.9	-0.9
Glucose	1.7	2.7	6.5	2.0	1.0	-2.5	-2.0	-0.6	0.6
Heart weight	1.2	1.9	3.7	0.6	-0.3	-1.9	-0.5	-1.9	1.9
Delay discount hyperbolic model param	0.2	0.3	0.8	0.4	0.9	0.5	-0.2	0.6	-0.6
Intermittent access intake day 1-15 change	0.4	2.3	3.4	1.4	1.8	-0.5	-1.8	1.6	-1.6
Intermittent access intake escalation	0.5	2.5	3.5	1.3	1.7	-0.5	-1.9	1.8	-1.8
Intermittent access intake escalation 2	1.2	2.0	2.8	1.3	1.3	-0.6	-1.6	1.7	-1.7
Intermitt. access day 1 inactive lever presses	0.0	0.4	1.0	0.5	1.0	0.1	-0.9	0.3	-0.3
Intermitt. access day 15 inactive lever presses	0.7	4.0	5.7	2.1	2.4	-2.2	-2.0	1.6	-1.6
Intermitt. access escalation Index	0.5	1.6	4.2	1.7	2.0	-0.7	-0.8	-0.9	0.9
Intermittent access day 1 total infusions	2.0	5.9	15.6	2.2	2.1	-4.0	-2.8	1.2	-1.2
Intermittent access day 15 total infusions	4.0	9.8	14.8	3.1	3.3	-3.6	-3.8	2.3	-2.3
Intermittent access terminal intake (last 3 days)	5.5	9.7	16.2	2.7	2.9	-4.0	-3.7	2.5	-2.5
Intermittent access total infusions	6.3	7.5	15.6	2.5	2.3	-4.0	-3.3	1.8	-1.8
Intermittent access day 1 locomotion	1.8	3.3	8.5	1.8	1.5	-2.9	-2.0	0.9	-0.9
Intermittent access day 15 total locomotion	2.2	8.6	11.0	2.7	2.7	-3.3	-3.2	2.8	-2.8
Intermittent access total locomotion	10.4	12.5	19.8	3.3	3.4	-4.5	-4.0	2.9	-2.9
Intermittent access standard deviation	0.3	1.7	2.9	1.6	1.3	-1.3	-1.7	0.9	-0.9
Left kidney weight	0.3	2.2	5.0	1.4	1.6	-2.2	-1.8	0.5	-0.5
Right kidney weight	0.2	1.3	2.1	1.2	1.3	-1.4	-1.3	0.6	-0.6
Cocaine induced anxiety	0.1	0.4	1.1	-0.1	0.1	-0.2	-0.3	1.1	-1.1
Post-drug Anxiety	0.3	0.4	0.8	-0.5	-0.9	0.1	0.2	0.7	-0.7
Baseline Anxiety	0.6	1.0	1.6	-0.5	-0.9	0.7	1.2	-1.3	1.3
Tail length	0.5	2.7	4.6	-1.7	-1.6	2.0	2.1	-1.2	1.2
Length with tail	1.3	5.8	9.9	-3.1	-3.1	2.0	3.1	-0.9	0.9
Length without tail	0.8	4.4	8.6	-2.7	-2.4	1.7	2.9	-1.0	1.0
Times rat made contact with spout	0.7	0.8	1.4	-1.0	-0.4	1.2	1.2	-0.6	0.6
Lifetime Intake	3.9	4.8	12.2	2.1	1.7	-3.5	-2.6	1.2	-1.2
Liver weight, left	0.4	0.7	1.2	1.0	0.4	-1.1	-0.7	-0.9	0.9
Liver weight, right	1.3	2.3	4.1	1.4	0.6	-1.6	-0.8	-2.0	2.0
Locomotor activity	0.9	1.5	3.4	1.3	0.5	-0.3	-0.1	-1.8	1.8
Locomotor testing distance	0.9	2.3	5.9	1.3	0.4	-0.2	-0.0	-2.4	2.4
Locomotor testing rearing	0.5	1.9	4.5	1.4	0.3	-0.4	-0.3	-2.1	2.1
Locomotion in novel chamber	3.4	4.5	7.3	2.7	2.6	-2.3	-2.6	0.7	-0.7
Locomotion in novel chamber post-restriction	1.1	3.3	6.1	2.5	1.9	-1.8	-2.3	0.8	-0.8
Fecal boli incidents, locomotor time 1	0.5	1.2	3.0	0.2	-0.2	-0.5	-0.9	1.7	-1.7
Change in fecal boli incidents, locomotor task	0.9	0.9	2.7	-0.1	0.1	-0.3	0.1	-1.6	1.6
Time >=10cm from walls, locomotor time 1	2.7	3.4	6.9	1.1	0.6	-2.6	-2.3	1.8	-1.8
Bouts of movement, locomotor time 1	1.6	2.1	7.1	-1.1	-0.8	2.7	1.2	0.9	-0.9
Total resting periods, locomotor time 1	1.4	1.6	5.2	-0.8	-0.4	2.3	0.9	1.2	-1.2
Rest time, locomotor task time 1	0.6	1.0	2.1	1.4	1.5	-0.2	-1.3	0.4	-0.4
Distance moved, locomotor task time 1	0.1	0.3	0.6	-0.7	-0.8	-0.8	0.3	-0.2	0.2
Vertical activity count, locomotor time 1	0.1	0.7	2.5	0.9	-0.0	-1.6	-0.8	-0.4	0.4
Time >=10cm from walls, locomotor time 2	0.4	1.0	2.7	0.1	0.3	-0.1	-0.7	1.6	-1.6
Bouts of movement, locomotor time 2	0.1	0.4	1.3	-0.5	-0.3	1.1	0.9	0.3	-0.3
Total resting periods, locomotor time 2	0.0	0.2	0.6	-0.3	-0.1	0.8	0.5	0.4	-0.4
Rest time, locomotor task time 2	0.9	1.5	3.2	1.8	0.8	-1.4	-1.7	-0.2	0.2
Distance moved, locomotor task time 2	0.7	1.0	2.0	-1.4	-0.8	1.3	1.2	0.2	-0.2
Vertical activity count, locomotor time 2	0.2	0.5	0.9	-0.2	-0.5	0.7	0.8	-0.9	0.9
Light reinforcement 1	0.0	0.1	0.3	0.4	-0.3	0.5	-0.0	-0.1	0.1
Light reinforcement 2	1.4	3.2	4.7	1.9	1.2	-1.6	-2.2	1.8	-1.8
Bone: marrow area	1.3	3.1	10.5	1.5	0.5	-3.2	-2.3	0.4	-0.4
Bone: maximum diameter	0.6	1.3	2.9	-0.1	-0.2	-1.0	-0.8	1.7	-1.7
Bone: maximum force	1.2	2.3	4.7	-1.9	-2.2	-0.8	0.7	1.5	-1.5
Bone: maximum moment	1.1	2.1	4.5	-1.9	-2.1	-0.7	0.7	1.3	-1.3
Mean time between licks in bursts	0.3	2.1	3.3	-0.9	-0.7	1.2	1.7	-1.8	1.8
Mean num. licks in bursts	0.1	0.3	0.7	0.2	0.3	0.3	0.2	-0.9	0.9
Cd content in liver	1.8	2.0	3.1	1.2	1.6	-0.9	-1.8	1.5	-1.5
Co content in liver	1.2	1.4	2.8	0.5	1.0	1.3	0.4	-1.7	1.7
Cu content in liver	0.1	0.1	0.2	0.1	0.4	0.4	-0.0	0.1	-0.1
Fe content in liver	0.2	0.2	0.8	-0.5	-0.9	-0.4	-0.0	0.1	-0.1
K content in liver	0.8	0.8	1.9	-1.0	-1.4	-0.1	0.9	-0.8	0.8
Mg content in liver	0.4	0.4	1.2	0.2	0.1	-0.4	0.1	-1.1	1.1
Mn content in liver	1.3	1.5	2.4	-1.5	-1.2	0.8	1.0	1.3	-1.3
Na content in liver	0.2	0.2	0.5	-0.7	-0.4	0.5	0.6	-0.0	0.0
Rb content in liver	1.1	1.2	1.9	1.4	0.7	-1.0	-0.8	-1.3	1.3
Se content in liver	1.0	1.2	2.3	0.6	0.9	-0.6	-1.0	1.5	-1.5
Sr content in liver	1.6	1.4	2.2	-1.5	-0.9	1.5	1.4	0.8	-0.8
Zn content in liver	0.4	0.5	1.3	-0.8	0.1	1.1	1.0	-0.1	0.1
Bone: minimum diameter	1.2	2.4	7.3	1.3	0.8	-2.7	-2.0	0.6	-0.6
Time in familiar zone, hab. session 1	0.1	0.1	0.3	0.3	0.2	-0.6	-0.1	-0.1	0.1
Time in novel zone, hab. session 1	0.4	0.4	1.2	0.3	0.1	0.2	-0.1	-1.1	1.1
Total zone transitions, hab. session 1	0.2	0.3	1.0	-0.8	-1.0	0.2	0.5	0.2	-0.2
Total locomotion distance, hab. session 1	0.4	0.6	2.1	0.7	0.1	-1.5	-0.9	-0.0	0.0
Locomotion velocity, hab. session 1	0.1	0.2	0.7	0.2	-0.2	-0.9	-0.3	0.1	-0.1
Time in familiar zone, hab. session 2	1.3	1.5	2.6	-0.7	-1.0	0.8	1.1	-1.6	1.6
Time in novel zone, hab. session 2	0.4	0.4	0.7	0.3	0.8	-0.4	-0.5	0.8	-0.8
Total zone transitions, hab. session 2	0.8	1.0	3.7	-1.2	-1.9	-0.4	0.9	-0.2	0.2
Total locomotion distance, hab. session 2	0.4	0.5	1.4	-0.0	-1.0	-1.2	-0.0	-0.6	0.6
Locomotion velocity, hab. session 2	0.4	0.5	2.3	0.3	-0.7	-1.5	-0.4	-0.2	0.2
Novel to familiar place preference ratio	1.0	1.4	3.8	-0.7	-0.2	0.1	0.1	2.0	-2.0
Novelty place preference	0.8	1.0	3.0	-0.3	0.2	-0.0	-0.1	1.7	-1.7
Time in novel zone, NPP test	0.6	0.7	2.1	-0.3	0.1	-0.1	-0.0	1.4	-1.4
Total zone transitions, NPP test	1.1	1.6	5.5	-1.7	-2.3	0.1	1.0	0.3	-0.3
Total locomotion distance, NPP test	0.3	0.4	1.2	-0.1	-1.1	-1.0	-0.0	-0.4	0.4
Locomotion velocity, NPP test	0.2	0.2	0.8	-0.2	-0.9	-0.8	-0.0	-0.1	0.1
Intraocular pressure	1.3	2.1	3.9	1.3	2.0	0.6	-1.1	1.6	-1.6
Delta distance traveled before/after self-admin	1.0	1.0	2.2	0.0	0.4	1.1	0.6	-1.5	1.5
Delta ambulatory time before/after self-admin	0.6	1.0	2.2	-0.2	0.5	1.0	0.6	-1.5	1.5
Parametrial fat weight	2.4	5.7	9.6	2.9	2.5	-3.1	-3.1	0.7	-0.7
Pavlov. Cond. lever latency	0.2	0.2	0.7	0.6	0.8	0.0	-0.6	-0.1	0.1
Pavlov. Cond. magazine entry latency	0.3	0.3	0.5	-0.6	-0.7	-0.4	0.2	0.7	-0.7
Pavlov. Cond. change in total contacts	0.7	0.8	2.2	0.1	0.2	-0.3	-0.5	1.5	-1.5
Pavlov. Cond. index score	0.2	0.3	0.5	-0.6	-0.4	0.3	0.4	0.7	-0.7
Pavlov. Cond. latency score	0.1	0.2	0.3	-0.5	-0.6	0.1	0.4	0.4	-0.4
Pavlov. Cond. lever contacts	0.1	0.1	0.4	-0.5	-0.6	-0.1	0.4	-0.1	0.1
Pavlov. Cond. magazine entry number	0.4	0.5	1.2	0.6	0.3	-0.6	-0.4	-1.1	1.1
Pavlov. Cond. intertrial magazine entries	0.7	0.8	2.8	1.0	1.7	0.4	-0.6	0.6	-0.6
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.7	-0.7	-0.6	0.3	0.4	0.8	-0.8
Pavlov. Cond. response bias	0.3	0.3	0.7	-0.5	-0.2	0.3	0.4	0.8	-0.8
Pavlov. Cond. lever latency	0.5	0.7	1.8	0.6	0.3	0.4	-0.1	-1.3	1.3
Pavlov. Cond. magazine entry latency	1.9	2.7	5.3	-2.3	-2.1	1.1	1.8	1.0	-1.0
Pavlov. Cond. change in total contacts	0.9	2.1	5.8	-0.9	-0.5	-0.0	0.1	2.4	-2.4
Pavlov. Cond. index score	1.1	1.7	3.0	-1.5	-1.2	0.2	0.8	1.7	-1.7
Pavlov. Cond. latency score	0.9	1.5	3.0	-1.3	-1.0	-0.1	0.5	1.7	-1.7
Pavlov. Cond. lever contacts	0.5	0.7	1.8	-0.6	-0.4	-0.2	0.1	1.3	-1.3
Pavlov. Cond. magazine entry number	3.0	3.9	7.2	2.7	2.2	-1.3	-1.9	-1.7	1.7
Pavlov. Cond. intertrial magazine entries	0.3	0.6	1.2	1.1	0.9	-0.6	-1.1	-0.0	0.0
Pavlov. Cond. lever-magazine prob. diff.	1.3	2.0	3.1	-1.7	-1.3	0.4	0.9	1.8	-1.8
Pavlov. Cond. response bias	1.1	1.5	2.2	-1.5	-1.2	0.3	0.9	1.5	-1.5
Time in closed arm before self-admin	0.8	1.5	2.6	0.6	1.6	-0.9	-1.2	1.3	-1.3
Time in closed arm after self-admin	0.4	0.4	0.8	0.8	-0.1	-0.5	-0.4	-0.9	0.9
Time in open arm before self-admin	3.2	3.9	9.7	-0.1	-1.5	0.6	1.2	-3.1	3.1
Time in open arm after self-admin	0.5	0.6	1.2	-0.8	-0.1	1.0	1.1	-0.6	0.6
Bone: periosteal estimation	0.6	1.4	4.3	0.3	-0.1	-2.1	-1.3	1.1	-1.1
Bone: periosteal perimeter	0.4	0.9	2.1	-0.1	-0.4	-1.4	-0.8	1.1	-1.1
Bone: post-yield work	2.4	4.2	9.7	0.1	-1.0	-3.1	-1.8	2.4	-2.4
Progressive ratio test 1 active lever presses	0.8	1.4	2.0	0.7	1.2	-1.4	-1.3	1.2	-1.2
Progressive ratio test 1 breakpoint	0.8	1.5	2.0	0.6	1.2	-1.4	-1.3	1.3	-1.3
Progressive ratio test 1 inactive lever presses	0.2	0.4	0.9	0.1	0.9	-0.3	-0.2	0.9	-0.9
Progressive ratio test 2 active lever presses	3.8	5.4	7.3	2.1	2.6	-2.4	-2.7	2.0	-2.0
Progressive ratio test 2 breakpoint	4.2	5.3	7.2	2.1	2.7	-2.3	-2.7	2.0	-2.0
Progressive ratio test 2 inactive lever presses	3.1	9.9	16.7	3.5	4.1	-3.1	-3.4	2.1	-2.1
Incentive Sensitization - Responses	0.3	0.8	1.3	0.4	0.2	-1.2	-0.9	1.1	-1.1
Incentive Sensitization - Breakpoint	0.4	1.0	1.5	0.7	0.5	-1.2	-1.1	1.1	-1.1
Sum of active levers in priming session hrs 5-6	2.9	2.7	7.2	-0.5	0.3	1.2	-0.0	2.7	-2.7
Progressive ratio	0.3	0.9	2.0	-1.0	-1.4	-0.8	-0.1	0.9	-0.9
Food seeking constrained by brief footshock	0.2	0.3	0.6	-0.4	0.2	0.1	0.4	-0.8	0.8
Seeking ratio, punishment vs. effort	0.9	2.0	3.9	1.0	1.6	0.6	0.4	-2.0	2.0
Retroperitoneal fat weight	4.3	19.1	38.3	6.2	5.2	-4.8	-4.8	-1.2	1.2
Reaction time number correct	0.1	0.4	1.0	-0.7	-0.3	0.8	1.0	-0.0	0.0
Reaction time mean minus median	0.4	2.7	4.3	-1.8	-2.1	0.6	0.6	2.0	-2.0
Reaction time mean minus median AUC	0.2	1.6	2.4	-1.6	-1.5	0.9	0.7	1.3	-1.3
Reaction time num false alarms	1.1	1.8	4.7	0.3	-0.6	0.5	0.8	-2.2	2.2
Reaction time num false alarms AUC	0.9	2.1	4.0	-0.4	-1.2	1.0	1.4	-2.0	2.0
Reaction time trials correct on left	0.1	0.4	1.0	-0.7	-0.3	0.8	1.0	-0.0	0.0
Reaction time trials on left	0.1	0.4	1.1	-0.8	-0.4	0.9	1.1	-0.0	0.0
Reaction time mean	0.3	0.7	1.8	-0.0	0.2	-0.2	-0.6	1.4	-1.4
Reaction time mean AUC	0.3	0.8	2.1	0.1	0.2	-0.4	-0.7	1.5	-1.5
Median of all reaction times	0.5	0.7	1.1	0.5	0.9	-0.6	-0.8	1.0	-1.0
Reaction time omissions	0.7	1.1	1.8	-1.4	-1.1	0.9	0.9	1.0	-1.0
Reaction time false alarm rate	0.9	1.3	3.4	0.3	-0.7	0.2	0.5	-1.8	1.8
Reaction time premature initiation rate	2.8	4.3	7.5	-2.2	-1.6	1.9	2.7	-1.9	1.9
Reaction time premature initiations	1.9	5.7	11.1	-2.8	-1.7	2.7	3.3	-1.6	1.6
Std. dev. reaction times	0.4	1.2	2.5	-0.8	-1.1	0.4	-0.0	1.6	-1.6
Reaction time trials completed	0.1	0.4	1.1	-0.8	-0.4	0.9	1.1	-0.0	0.0
Reaction time trials AUC	0.1	0.4	1.0	-0.7	-0.3	0.7	1.0	-0.2	0.2
Run reversals in cocaine runway, females	1.5	1.7	3.6	-0.7	-1.0	-0.7	0.9	-1.9	1.9
Run reversals in cocaine runway, males	0.1	0.1	0.3	-0.0	0.5	-0.0	-0.1	-0.3	0.3
Latency to leave start box in cocaine runway	0.4	0.5	1.4	0.7	0.2	-1.2	-1.0	0.3	-0.3
Latency to leave start box in cocaine runway, F	0.1	0.1	0.2	0.4	-0.1	-0.4	-0.3	0.3	-0.3
Latency to leave start box in cocaine runway, M	0.4	0.4	1.2	0.2	-0.3	-1.1	-1.0	-0.0	0.0
Std. dev. time between licks in bursts	0.8	1.6	3.9	-0.2	-0.5	0.7	1.0	-2.0	2.0
Total sessions with >9 infusions	0.5	0.6	2.4	0.3	-0.2	-1.6	-0.9	0.4	-0.4
Short access day 1 total inactive lever presses	1.2	2.3	4.2	2.0	1.9	-1.9	-1.4	-0.5	0.5
Short access day 10 total inactive lever presses	0.1	0.7	1.3	0.8	0.7	0.1	-0.4	-1.1	1.1
Short access day 1 total infusions	1.1	2.2	5.8	1.7	1.2	-2.4	-1.7	0.1	-0.1
Short access day 10 total infusions	1.6	2.7	10.0	1.0	0.5	-3.2	-1.8	1.0	-1.0
Short access total infusions	1.3	1.8	7.9	0.9	0.3	-2.8	-1.3	0.2	-0.2
Short access day 1 locomotion	0.9	1.5	3.2	1.5	1.2	-1.8	-1.5	0.3	-0.3
Short access day 10 total locomotion	0.5	2.2	3.7	1.2	1.5	-1.9	-1.6	1.3	-1.3
Short access total locomotion	1.7	2.6	5.5	1.6	1.5	-2.4	-1.9	1.0	-1.0
One hour access (0.3 mA shock)	5.0	5.9	9.6	3.0	3.1	-2.7	-2.9	0.7	-0.7
Compulsive drug intake	4.2	6.3	9.3	-1.9	-1.8	3.1	2.7	-2.7	2.7
One hour access (shock baseline)	4.3	11.3	16.4	3.4	4.0	-3.6	-4.0	2.3	-2.3
Social response proportion	0.4	0.5	0.8	-0.9	-0.8	0.3	0.5	0.8	-0.8
Social responses	0.6	0.7	1.5	-1.0	-1.2	0.9	1.0	-0.1	0.1
Social time	0.4	0.6	1.4	-0.9	-1.2	0.9	0.9	-0.3	0.3
Soleus weight	1.9	5.7	12.1	3.5	3.1	-2.0	-2.6	-0.9	0.9
Bone: stiffness	1.1	2.0	3.1	-1.6	-1.7	-0.5	0.3	1.8	-1.8
Tibialis anterior weight	4.7	16.3	36.9	-6.1	-4.8	3.6	4.7	1.2	-1.2
Time to tail flick, vehicle, before self-admin	0.2	0.3	0.7	-0.2	-0.5	-0.8	-0.3	0.5	-0.5
Time to tail flick, vehicle, after self-admin	0.8	1.6	5.3	-1.5	-2.3	-0.6	0.8	-0.7	0.7
Time to tail flick, test, before self-admin	1.1	1.3	3.3	1.0	1.0	-1.8	-0.6	-1.0	1.0
Time to tail flick, test, after self-admin	0.4	0.4	0.9	-0.3	-0.9	-0.1	-0.1	0.9	-0.9
Delta time to tail flick, vehicle, before/after SA	1.1	1.1	3.3	-1.1	-1.8	0.2	1.0	-0.8	0.8
Delta time to tail flick, test, before/after SA	1.7	2.1	5.0	-1.0	-1.1	2.2	0.7	1.6	-1.6
Tibia length	1.1	3.1	8.6	-1.0	-0.2	0.4	0.0	2.9	-2.9
Ambulatory time before self-admin	0.4	1.4	3.6	-0.5	-0.7	-0.4	-0.1	1.9	-1.9
Ambulatory time after self-admin	0.4	0.6	1.5	0.5	1.2	-0.3	-0.5	0.9	-0.9
Bone: tissue strength	0.1	0.1	0.2	0.3	0.1	-0.0	-0.2	0.4	-0.4
Total heroin consumption	3.2	3.8	6.9	-2.6	-2.2	2.1	2.3	0.8	-0.8
Bone: trabecular number	0.5	0.9	1.7	-0.7	-0.9	-0.8	-0.1	1.3	-1.3
Bone: trabecular spacing	0.6	0.8	1.9	0.4	0.4	0.8	0.4	-1.4	1.4
Bone: trabecular thickness	0.4	0.6	1.4	1.0	0.4	-1.2	-1.0	0.2	-0.2
Bone: trabecular tissue density	1.4	2.4	6.3	2.5	1.8	-1.0	-2.0	0.2	-0.2
Water consumed over 24 hours	0.6	1.2	3.1	-1.4	-0.6	1.8	1.4	-0.2	0.2
Number of responses in last shaping day	0.3	0.3	0.5	-0.1	-0.2	0.6	0.7	-0.7	0.7