Hub : Genes

Tut1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Tut1 0.12 0.1 7.9e-04 0 0.02 0.01 0.01 1.5e-01 9.1e-04 7.8e-03 1.3e-02
2 PL gene expression Tut1 0.04 0.02 1.1e-05 0.05 0.04 0.05 0.04 5.7e-06 9.2e-06 5.7e-06 9.3e-06
3 NAcc gene expression Tut1 0.02 0.01 1.5e-03 0.01 0.01 0.01 0.01 2.8e-02 8.7e-03 1.2e-02 2.3e-02
4 RMTg mRNA stability Tut1 0.1 0.07 5.4e-03 0.05 0.06 0.03 0.02 1.9e-02 1.0e-02 6.4e-02 8.1e-02
5 OFC gene expression Tut1 0.21 0.15 7.6e-03 0.09 0.07 0.04 0.1 4.7e-03 8.2e-03 3.7e-02 2.9e-03
6 Brain gene expression Tut1 0.09 0.05 7.1e-11 0.12 0.11 0.12 0.12 2.8e-11 3.1e-10 7.3e-11 3.3e-11

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bone: apparent density0.30.62.01.40.5-0.40.8-0.30.5
Area under the delay curve0.00.00.10.00.0-0.10.3-0.30.3
BMI with tail2.47.912.23.52.7-2.33.1-2.62.4
BMI without tail1.12.33.11.11.5-1.51.7-1.81.4
Body weight3.715.517.53.34.2-3.94.2-4.13.9
Weight adjusted by age1.61.83.21.81.4-1.21.5-1.10.9
Bone surface1.93.48.22.91.8-1.31.9-1.31.4
Bone volume0.91.65.82.41.1-0.61.2-0.60.7
Breakpoint value in progressive ratio session1.61.72.61.01.6-1.51.4-1.11.2
Number of licking bursts0.00.00.0-0.10.10.1-0.0-0.10.1
Context. condit. distance diff. score0.20.30.9-0.4-0.90.5-0.40.5-0.1
Locomotion velocity, session 10.10.10.2-0.3-0.3-0.20.1-0.30.5
Locomotion distance, session 10.70.91.80.50.6-0.91.0-1.01.3
Locomotion velocity, session 22.73.23.81.51.8-1.81.9-1.72.0
Locomotion distance, session 20.30.40.9-0.30.4-0.70.6-0.71.0
Locomotion velocity, session 30.50.50.90.90.5-0.40.8-0.80.9
Locomotion distance, session 30.10.10.3-0.10.3-0.30.2-0.60.4
Stereotopy head waving bouts, day 30.10.10.30.3-0.50.40.10.40.4
Stereotopy head waving duration, day 30.10.20.5-0.3-0.70.3-0.00.40.4
Locomotion velocity, session 70.00.00.10.2-0.30.20.00.30.1
Locomotion distance, session 70.10.10.2-0.4-0.50.2-0.10.00.1
Stereotopy head waving bouts, day 70.20.20.80.90.2-0.10.50.20.5
Stereotopy head waving duration, day 71.82.22.81.71.6-1.41.6-1.21.5
Locomotion velocity, session 80.30.31.3-1.1-0.5-0.2-0.1-0.10.5
Locomotion distance, session 80.10.20.6-0.1-0.70.5-0.20.50.1
Degree of sensitization distance0.10.10.20.5-0.40.30.10.3-0.0
Degree of sensitization stereotypy0.91.02.21.51.1-0.81.0-0.40.8
Conditioned locomotion0.50.60.80.40.7-0.90.9-0.70.9
Cocaine response after cond. corrected0.60.71.6-1.2-1.30.6-0.70.5-0.2
Cocaine response after cond. not corrected0.40.51.1-0.7-1.00.7-0.70.4-0.5
Cocaine response before conditioning0.50.62.21.50.9-0.20.4-0.3-0.5
Saline control response2.53.24.21.01.9-1.91.8-2.11.9
Bone: connectivity density1.72.64.52.11.6-1.41.8-1.31.4
Bone: cortical apparent density0.40.51.00.10.7-0.90.7-0.61.0
Bone: cortical area0.91.42.91.71.3-0.81.1-1.10.9
Bone: cortical porosity0.10.10.4-0.7-0.30.1-0.20.50.1
Bone: cortical porosity0.10.10.4-0.60.0-0.40.10.10.4
Bone: cortical thickness3.04.96.90.92.4-2.52.1-2.62.4
Bone: cortical thickness0.60.71.3-0.20.7-1.00.6-1.10.9
Bone: cortical tissue density0.50.71.30.10.8-1.00.7-0.71.1
Condit. Reinf. active minus inactive responses1.01.21.41.21.1-1.01.1-0.91.1
Condit. Reinf. active-inactive response ratio0.40.40.60.30.6-0.80.6-0.60.8
Condit. Reinf. active responses1.01.33.31.81.1-0.81.1-0.60.9
Condit. Reinf. inactive responses0.30.41.71.30.10.40.10.4-0.5
Incentive salience index mean1.41.83.01.71.3-1.11.4-1.21.1
Condit. Reinf. lever presses0.91.33.01.71.1-0.71.1-1.00.8
Condit. Reinf. active minus inactive responses0.40.51.00.1-0.50.8-0.71.0-0.8
Condit. Reinf. active-inactive response ratio1.01.12.50.6-0.71.2-0.71.6-1.1
Condit. Reinf. active responses0.00.00.10.30.20.1-0.10.0-0.0
Condit. Reinf. inactive responses0.30.31.1-0.30.5-0.50.2-1.00.5
Condit. Reinf. lever presses0.91.22.61.61.3-0.81.0-0.90.5
Condit. Reinf. lever reinforcers received0.10.10.30.50.5-0.20.2-0.20.1
Conditioned reinforcement - actives2.42.43.5-0.5-1.51.7-1.51.9-1.8
Conditioned reinforcement - inactives1.01.11.80.5-0.91.3-0.81.2-1.3
Conditioned locomotion1.92.33.2-0.3-1.61.8-1.31.8-1.6
Patch foraging indifference point 0 sec0.50.91.30.60.9-1.01.0-0.91.1
Patch foraging indifference point AUC2.02.33.61.91.8-1.41.6-1.01.2
Delay disc. indifference point, 0s delay0.10.10.3-0.4-0.60.4-0.20.0-0.1
Delay disc. indifference point, 16s delay0.20.20.90.90.3-0.10.4-0.20.2
Delay disc. indifference point, 2s delay0.20.20.30.2-0.50.6-0.20.4-0.5
Delay disc. indifference point, 24s delay0.20.20.4-0.20.2-0.50.3-0.60.5
Delay disc. indifference point, 4s delay0.50.61.1-0.10.4-0.70.7-1.01.1
Delay disc. indifference point, 8s delay0.40.41.5-1.2-0.70.3-0.50.2-0.0
Indifference point function ln k2.83.96.4-2.3-2.51.9-2.11.2-1.5
Indifference point function log k2.83.96.4-2.3-2.51.9-2.11.2-1.5
Patch foraging total patch changes 0 sec0.60.91.50.20.8-1.10.9-1.11.2
Patch foraging total patch changes 12 sec5.97.69.22.22.9-3.03.0-2.43.0
Patch foraging total patch changes 18 sec0.40.50.70.50.8-0.80.8-0.50.8
Patch foraging total patch changes 24 sec7.59.111.02.53.1-3.13.2-2.93.3
Patch foraging total patch changes 6 sec1.11.72.31.01.2-1.41.4-1.21.5
Patch foraging time to switch 0 sec0.50.72.61.60.6-0.40.9-0.10.4
Patch foraging water rate 0 sec0.40.61.3-1.1-0.90.6-1.00.4-0.6
Patch foraging water rate 12 sec1.52.35.4-2.3-1.61.2-1.70.6-1.0
Patch foraging water rate 18 sec0.50.72.1-1.4-1.00.6-0.8-0.1-0.2
Patch foraging water rate 24 sec1.21.72.9-1.7-1.51.1-1.40.9-1.0
Patch foraging water rate 6 sec1.11.64.4-2.1-1.30.9-1.40.6-0.7
Seeking ratio, delayed vs. immediate footshock0.00.00.10.10.1-0.10.1-0.30.2
Distance traveled before self-admin2.32.43.92.01.7-1.41.5-1.31.3
Distance traveled after self-admin0.20.30.50.70.7-0.50.4-0.40.3
Extensor digitorum longus weight6.726.530.14.45.5-5.15.3-5.25.3
Bone: elastic displacement0.70.82.6-1.6-0.80.4-0.90.5-0.4
Bone: elastic work0.81.11.7-0.10.9-1.30.9-1.31.3
Bone: endosteal estimation1.12.54.30.8-1.62.1-1.21.7-1.8
Bone: endosteal perimeter1.94.06.91.0-1.82.6-1.52.3-2.3
Epididymis fat weight0.30.61.30.2-0.51.1-0.70.4-1.2
Delta time in closed arm before/after self-admin2.02.03.2-0.21.0-1.61.4-1.81.8
Delta time in open arm before/after self-admin1.51.43.21.81.3-1.01.2-0.50.9
Diff in mean of infusions in LGA sessions1.51.72.60.41.4-1.61.3-1.21.5
Delay discount exponential model param0.00.00.10.0-0.00.1-0.20.3-0.3
Extinction: sum of active levers before priming3.83.84.51.92.1-2.02.0-1.72.0
Active lever presses in extinction session 62.32.23.11.81.8-1.51.5-1.01.3
Bone: final force2.23.55.72.41.9-1.61.9-1.61.7
Bone: final moment2.13.45.52.31.9-1.51.9-1.61.6
Food consumed during 24 hour testing period0.10.10.30.1-0.10.4-0.40.3-0.5
Glucose2.53.85.3-1.0-2.02.3-2.02.0-2.2
Heart weight0.71.01.5-1.2-1.21.0-0.90.7-0.9
Delay discount hyperbolic model param0.10.10.1-0.1-0.00.1-0.30.3-0.4
Intermittent access intake day 1-15 change1.51.52.3-0.6-1.01.3-1.31.4-1.5
Intermittent access intake escalation0.90.91.5-0.4-0.71.0-1.01.1-1.2
Intermittent access intake escalation 20.10.10.20.30.00.2-0.20.4-0.4
Intermitt. access day 1 inactive lever presses1.71.82.5-0.7-1.51.6-1.31.5-1.4
Intermitt. access day 15 inactive lever presses0.40.42.41.50.30.20.4-0.1-0.1
Intermitt. access escalation Index0.20.20.4-0.6-0.60.3-0.30.1-0.1
Intermittent access day 1 total infusions0.80.91.60.8-1.01.3-0.40.9-1.0
Intermittent access day 15 total infusions3.33.75.4-0.1-2.02.3-1.72.2-2.3
Intermittent access terminal intake (last 3 days)1.01.11.61.3-0.81.2-0.41.1-1.2
Intermittent access total infusions1.11.21.90.8-1.01.4-0.61.2-1.3
Intermittent access day 1 locomotion0.30.31.01.0-0.50.50.20.2-0.2
Intermittent access day 15 total locomotion0.40.41.11.1-0.40.7-0.00.7-0.6
Intermittent access total locomotion0.91.04.42.1-0.30.80.30.6-0.5
Intermittent access standard deviation1.51.62.3-0.8-1.11.3-1.31.4-1.5
Left kidney weight0.00.10.50.70.30.00.3-0.1-0.0
Right kidney weight0.20.51.91.40.6-0.20.7-0.20.3
Cocaine induced anxiety0.20.30.70.80.5-0.40.5-0.30.3
Post-drug Anxiety0.60.61.31.10.9-0.70.8-0.60.6
Baseline Anxiety1.11.11.50.51.1-1.21.0-1.21.2
Tail length1.03.04.4-0.11.9-2.11.5-2.11.8
Length with tail2.38.510.31.83.2-3.12.9-3.13.1
Length without tail1.94.34.91.92.1-2.02.1-2.02.2
Times rat made contact with spout0.30.30.5-0.60.3-0.60.2-0.70.7
Lifetime Intake0.80.91.60.4-1.01.3-0.61.0-1.2
Liver weight, left0.30.50.8-0.9-0.70.7-0.80.5-0.7
Liver weight, right0.00.00.10.40.10.10.1-0.40.1
Locomotor activity0.91.45.3-2.3-1.20.6-1.10.3-0.6
Locomotor testing distance1.01.65.9-2.4-1.30.6-1.10.2-0.6
Locomotor testing rearing0.91.42.9-1.7-1.21.0-1.30.6-1.0
Locomotion in novel chamber2.43.04.80.1-1.52.0-1.52.2-2.1
Locomotion in novel chamber post-restriction2.63.13.8-1.6-1.91.8-1.72.0-1.4
Fecal boli incidents, locomotor time 10.50.61.10.7-0.30.8-0.51.0-0.9
Change in fecal boli incidents, locomotor task0.70.62.0-1.4-1.00.5-0.70.1-0.1
Time >=10cm from walls, locomotor time 12.52.54.20.3-1.52.0-1.42.0-1.7
Bouts of movement, locomotor time 10.10.10.4-0.60.2-0.50.00.10.2
Total resting periods, locomotor time 10.10.10.2-0.20.3-0.50.10.10.1
Rest time, locomotor task time 11.31.41.9-1.3-1.01.2-1.41.1-1.1
Distance moved, locomotor task time 10.30.30.70.80.5-0.50.6-0.50.4
Vertical activity count, locomotor time 10.60.60.9-0.6-1.00.8-0.80.8-0.8
Time >=10cm from walls, locomotor time 20.30.30.60.4-0.30.5-0.40.8-0.6
Bouts of movement, locomotor time 21.21.31.80.81.3-1.31.2-1.21.1
Total resting periods, locomotor time 20.60.60.90.50.9-0.90.8-0.80.7
Rest time, locomotor task time 23.23.74.2-1.8-2.12.0-2.01.9-1.7
Distance moved, locomotor task time 20.40.40.70.40.8-0.90.6-0.70.4
Vertical activity count, locomotor time 20.30.31.6-1.3-0.2-0.3-0.3-0.20.0
Light reinforcement 10.10.10.3-0.5-0.30.3-0.50.2-0.4
Light reinforcement 20.60.81.41.2-0.10.9-0.41.1-1.0
Bone: marrow area1.32.74.80.7-1.72.2-1.31.8-1.9
Bone: maximum diameter0.30.52.81.70.50.00.5-0.10.1
Bone: maximum force3.05.111.93.42.3-1.62.3-1.71.7
Bone: maximum moment2.84.710.73.32.2-1.62.3-1.71.6
Mean time between licks in bursts0.81.22.9-0.30.7-1.30.9-1.71.0
Mean num. licks in bursts0.10.10.5-0.7-0.2-0.1-0.20.10.0
Cd content in liver1.31.52.2-0.6-1.41.3-1.11.5-1.2
Co content in liver2.32.77.2-2.7-1.61.0-1.81.0-1.1
Cu content in liver0.30.40.6-0.50.4-0.80.5-0.70.8
Fe content in liver0.00.00.20.2-0.10.10.00.4-0.1
K content in liver1.41.42.91.71.2-0.81.2-1.00.9
Mg content in liver0.60.61.91.40.7-0.30.8-0.60.7
Mn content in liver2.12.43.21.61.8-1.51.6-1.41.3
Na content in liver0.70.71.81.40.9-0.60.8-0.60.6
Rb content in liver1.21.41.9-1.1-1.41.3-1.30.9-1.1
Se content in liver0.30.41.71.30.6-0.20.60.10.0
Sr content in liver5.55.05.91.62.4-2.42.4-2.22.3
Zn content in liver4.14.55.22.22.2-2.12.3-1.72.2
Bone: minimum diameter0.71.32.31.3-0.81.5-0.71.1-1.3
Time in familiar zone, hab. session 10.20.20.60.80.2-0.20.3-0.3-0.2
Time in novel zone, hab. session 11.41.32.3-1.5-1.21.0-1.30.8-0.9
Total zone transitions, hab. session 10.30.41.30.10.5-0.70.6-0.51.1
Total locomotion distance, hab. session 10.10.10.30.4-0.40.4-0.00.60.2
Locomotion velocity, hab. session 10.20.20.60.60.2-0.20.50.00.8
Time in familiar zone, hab. session 20.40.41.0-1.0-0.40.4-0.8-0.0-0.8
Time in novel zone, hab. session 20.60.60.91.00.6-0.60.9-0.50.8
Total zone transitions, hab. session 21.72.12.81.21.4-1.41.5-1.71.6
Total locomotion distance, hab. session 20.20.30.50.60.3-0.30.5-0.50.7
Locomotion velocity, hab. session 20.10.20.50.70.2-0.00.4-0.20.6
Novel to familiar place preference ratio2.02.02.81.41.7-1.41.6-1.21.2
Novelty place preference1.11.21.71.11.3-1.01.2-0.90.8
Time in novel zone, NPP test1.21.31.81.11.3-1.11.3-1.00.9
Total zone transitions, NPP test1.31.83.00.71.2-1.41.4-1.41.7
Total locomotion distance, NPP test0.10.20.5-0.00.1-0.40.4-0.30.7
Locomotion velocity, NPP test0.10.10.5-0.2-0.1-0.20.2-0.10.7
Intraocular pressure0.10.20.3-0.5-0.20.3-0.50.4-0.5
Delta distance traveled before/after self-admin0.60.61.4-1.2-0.80.6-0.90.5-0.6
Delta ambulatory time before/after self-admin1.01.12.8-1.7-1.00.8-1.10.7-0.8
Parametrial fat weight1.32.54.20.1-1.52.0-1.51.9-1.7
Pavlov. Cond. lever latency1.31.74.1-2.0-1.21.0-1.41.0-1.0
Pavlov. Cond. magazine entry latency1.21.54.92.21.2-0.81.2-0.60.5
Pavlov. Cond. change in total contacts0.60.63.01.70.5-0.10.60.3-0.0
Pavlov. Cond. index score0.60.82.51.60.9-0.60.9-0.40.4
Pavlov. Cond. latency score0.60.72.31.50.8-0.50.8-0.50.4
Pavlov. Cond. lever contacts0.30.41.41.20.6-0.30.6-0.40.3
Pavlov. Cond. magazine entry number0.60.72.3-1.5-1.00.6-0.80.2-0.3
Pavlov. Cond. intertrial magazine entries0.00.00.00.00.2-0.10.00.2-0.0
Pavlov. Cond. lever-magazine prob. diff.0.81.02.91.71.0-0.71.0-0.40.5
Pavlov. Cond. response bias0.80.93.01.71.1-0.60.9-0.40.3
Pavlov. Cond. lever latency0.50.72.1-1.5-0.80.5-0.80.7-0.2
Pavlov. Cond. magazine entry latency4.04.65.62.32.4-2.22.2-2.11.5
Pavlov. Cond. change in total contacts1.52.06.02.51.6-0.91.3-0.90.5
Pavlov. Cond. index score2.53.26.92.62.0-1.51.8-1.50.9
Pavlov. Cond. latency score2.32.96.62.61.9-1.41.7-1.40.8
Pavlov. Cond. lever contacts0.30.51.21.10.8-0.50.6-0.6-0.0
Pavlov. Cond. magazine entry number6.68.110.0-3.2-3.22.8-3.02.6-2.1
Pavlov. Cond. intertrial magazine entries1.62.12.4-1.4-1.41.5-1.61.5-1.1
Pavlov. Cond. lever-magazine prob. diff.2.93.67.22.72.1-1.71.9-1.71.0
Pavlov. Cond. response bias1.52.03.51.91.6-1.31.4-1.30.7
Time in closed arm before self-admin0.20.20.60.80.00.4-0.10.4-0.5
Time in closed arm after self-admin0.40.50.9-1.0-0.80.6-0.70.2-0.6
Time in open arm before self-admin1.21.35.4-2.3-1.10.4-1.00.1-0.2
Time in open arm after self-admin0.10.10.4-0.60.1-0.40.00.00.4
Bone: periosteal estimation0.30.73.21.8-0.00.70.10.4-0.5
Bone: periosteal perimeter0.30.42.01.40.10.60.00.3-0.4
Bone: post-yield work1.21.65.52.3-0.41.2-0.11.1-1.1
Progressive ratio test 1 active lever presses2.12.22.9-0.8-1.71.5-1.31.7-1.6
Progressive ratio test 1 breakpoint2.42.53.2-0.9-1.81.6-1.51.8-1.7
Progressive ratio test 1 inactive lever presses0.10.10.20.20.1-0.30.4-0.30.3
Progressive ratio test 2 active lever presses1.71.92.70.0-1.41.6-1.11.6-1.6
Progressive ratio test 2 breakpoint2.83.14.2-0.5-1.92.0-1.62.1-2.0
Progressive ratio test 2 inactive lever presses0.80.91.30.7-0.91.2-0.51.1-1.1
Incentive Sensitization - Responses0.30.31.61.30.20.00.40.0-0.0
Incentive Sensitization - Breakpoint0.30.31.51.20.10.20.30.1-0.2
Sum of active levers in priming session hrs 5-60.80.81.81.31.2-0.80.8-0.30.5
Progressive ratio0.10.20.80.90.30.20.10.1-0.2
Food seeking constrained by brief footshock0.10.10.6-0.7-0.30.1-0.3-0.10.0
Seeking ratio, punishment vs. effort0.30.41.9-1.4-0.5-0.2-0.2-0.20.3
Retroperitoneal fat weight2.16.89.3-1.6-2.93.0-2.62.5-2.8
Reaction time number correct0.60.92.00.21.1-1.00.7-1.40.9
Reaction time mean minus median0.20.31.01.00.6-0.30.50.4-0.0
Reaction time mean minus median AUC0.00.00.10.10.3-0.30.10.3-0.1
Reaction time num false alarms0.50.73.4-1.9-0.70.0-0.5-0.1-0.1
Reaction time num false alarms AUC0.50.73.0-1.7-0.1-0.6-0.0-0.70.6
Reaction time trials correct on left0.60.92.00.21.1-1.00.7-1.40.9
Reaction time trials on left0.71.02.00.21.1-1.00.7-1.40.9
Reaction time mean0.20.31.00.5-0.30.3-0.31.0-0.7
Reaction time mean AUC0.30.41.00.5-0.30.5-0.41.0-0.9
Median of all reaction times0.10.20.50.7-0.10.10.00.6-0.4
Reaction time omissions0.10.10.3-0.60.0-0.40.10.10.2
Reaction time false alarm rate0.40.52.3-1.5-0.80.1-0.40.2-0.1
Reaction time premature initiation rate4.56.08.71.62.5-2.52.4-3.02.5
Reaction time premature initiations5.78.012.51.43.0-3.02.7-3.52.9
Std. dev. reaction times0.30.41.2-0.1-0.40.4-0.51.1-0.7
Reaction time trials completed0.71.02.00.21.1-1.00.7-1.40.9
Reaction time trials AUC0.50.81.70.11.0-0.90.6-1.30.8
Run reversals in cocaine runway, females1.11.11.90.50.7-1.01.1-1.31.4
Run reversals in cocaine runway, males0.60.61.2-1.1-0.80.6-0.80.6-0.4
Latency to leave start box in cocaine runway0.30.30.50.3-0.60.7-0.40.6-0.6
Latency to leave start box in cocaine runway, F0.00.00.20.40.1-0.00.2-0.00.0
Latency to leave start box in cocaine runway, M3.12.93.6-1.1-1.91.9-1.71.7-1.8
Std. dev. time between licks in bursts0.20.31.0-1.0-0.50.1-0.4-0.4-0.3
Total sessions with >9 infusions1.41.52.1-0.5-1.51.5-1.11.3-1.4
Short access day 1 total inactive lever presses0.70.81.3-0.2-1.21.1-0.70.9-0.9
Short access day 10 total inactive lever presses2.22.43.3-1.8-1.81.5-1.61.3-1.3
Short access day 1 total infusions0.70.71.1-0.4-1.01.1-0.80.8-1.0
Short access day 10 total infusions0.30.30.80.9-0.50.8-0.00.4-0.5
Short access total infusions0.30.30.60.1-0.70.8-0.30.5-0.6
Short access day 1 locomotion0.20.20.80.90.1-0.00.5-0.30.2
Short access day 10 total locomotion0.20.21.01.00.10.10.4-0.10.2
Short access total locomotion0.40.51.61.20.3-0.20.8-0.40.5
One hour access (0.3 mA shock)3.64.36.0-0.7-2.22.4-2.02.3-2.3
Compulsive drug intake1.71.72.6-0.91.2-1.60.8-1.61.4
One hour access (shock baseline)5.26.08.5-0.4-2.52.9-2.32.9-2.8
Social response proportion0.20.20.50.20.5-0.40.4-0.70.1
Social responses0.10.20.4-0.60.4-0.40.1-0.50.3
Social time0.20.31.3-1.10.1-0.2-0.2-0.40.3
Soleus weight2.47.28.6-2.2-2.92.9-2.92.5-2.6
Bone: stiffness0.91.54.82.21.2-0.71.1-0.70.6
Tibialis anterior weight9.733.338.24.56.2-6.06.0-5.56.1
Time to tail flick, vehicle, before self-admin0.70.72.31.50.7-0.40.9-0.50.5
Time to tail flick, vehicle, after self-admin0.50.60.90.40.6-0.70.8-1.00.9
Time to tail flick, test, before self-admin0.50.50.90.60.4-0.40.7-0.90.9
Time to tail flick, test, after self-admin0.10.10.1-0.4-0.30.3-0.30.1-0.3
Delta time to tail flick, vehicle, before/after SA0.10.10.2-0.5-0.0-0.20.0-0.30.3
Delta time to tail flick, test, before/after SA0.20.20.3-0.5-0.10.1-0.40.5-0.5
Tibia length1.44.09.03.02.2-1.62.1-1.01.5
Ambulatory time before self-admin2.02.04.42.11.6-1.21.4-1.01.0
Ambulatory time after self-admin0.30.31.51.20.6-0.20.4-0.10.1
Bone: tissue strength0.20.20.6-0.3-0.10.5-0.60.2-0.7
Total heroin consumption3.23.85.40.92.2-2.31.9-1.92.1
Bone: trabecular number0.81.23.31.81.0-0.81.2-0.70.8
Bone: trabecular spacing0.40.52.0-1.4-0.50.3-0.80.0-0.6
Bone: trabecular thickness0.40.51.00.5-0.60.8-0.51.0-0.8
Bone: trabecular tissue density4.36.17.2-2.6-2.72.4-2.62.4-2.2
Water consumed over 24 hours0.50.61.10.10.9-0.80.6-1.00.8
Number of responses in last shaping day0.10.10.4-0.7-0.1-0.20.0-0.20.1