Hub : Genes

Tut1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Tut1 0.13 0.1 2.6e-04 0.01 0.03 0.03 0.02 8.7e-03 1.7e-04 6.1e-04 1.6e-03
2 RMTg alternative TSS NM_001033901.1 0.36 0.14 6.6e-10 0.25 0.24 0.24 0.26 2.2e-07 5.5e-07 5.5e-07 1.2e-07
3 RMTg alternative TSS NM_001033901.1 0.23 0.12 4.7e-06 0.14 0.13 0.13 0.15 1.1e-04 2.2e-04 2.7e-04 1.1e-04
4 RMTg alternative TSS XM_063271615.1 0.36 0.14 6.0e-10 0.26 0.24 0.24 0.26 1.6e-07 5.0e-07 3.9e-07 1.0e-07
5 RMTg isoform ratio XM_063271615.1 0.35 0.14 1.4e-09 0.23 0.23 0.23 0.23 7.9e-07 7.5e-07 7.8e-07 7.3e-07
6 RMTg isoform ratio XM_063271617.1 0.34 0.14 7.4e-09 0.2 0.22 0.21 0.22 4.8e-06 2.0e-06 3.6e-06 1.9e-06
7 pVTA gene expression Tut1 0.05 0.03 6.8e-05 0.05 0.05 0.04 0.05 4.8e-05 1.1e-04 3.0e-04 1.2e-04
8 RMTg alternative TSS XM_063271615.1 0.32 0.14 8.9e-09 0.23 0.21 0.21 0.23 7.7e-07 3.4e-06 3.2e-06 8.8e-07
9 Brain gene expression Tut1 0.09 0.04 1.1e-10 0.12 0.11 0.11 0.11 7.8e-11 2.1e-10 2.3e-10 2.3e-10
10 NAcc gene expression Tut1 0.03 0.02 2.0e-05 0.03 0.03 0.02 0.03 7.5e-06 1.3e-05 2.2e-04 2.6e-05
11 RMTg isoform ratio XM_063271613.1 0.17 0.1 2.5e-04 0.02 0.07 0.08 0.05 9.4e-02 6.1e-03 4.6e-03 2.4e-02
12 PL gene expression Tut1 0.04 0.02 5.4e-06 0.05 0.05 0.05 0.05 5.0e-06 3.6e-06 3.1e-06 4.7e-06
13 RMTg mRNA stability Tut1 0.23 0.13 5.0e-04 0.05 0.06 0.08 0.06 1.9e-02 1.3e-02 4.1e-03 8.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.40.72.11.50.70.7-0.7-1.0-0.80.60.50.70.7-1.30.8-0.5
Area under the delay curve0.10.10.50.00.10.1-0.1-0.2-0.20.20.40.40.4-0.20.3-0.7
BMI with tail2.58.814.73.82.72.7-2.7-3.5-3.12.72.62.62.6-3.53.0-2.7
BMI without tail0.31.83.60.81.21.2-1.2-1.5-1.41.11.61.41.4-1.60.9-1.9
Body weight3.515.119.63.84.04.0-4.0-4.4-4.33.73.93.83.8-3.53.9-3.4
Weight adjusted by age0.41.13.11.41.11.1-1.1-1.2-1.11.00.90.70.7-1.80.8-0.5
Bone surface2.24.49.33.12.12.1-2.1-2.5-2.31.91.51.71.7-2.32.1-1.0
Bone volume1.02.06.42.51.31.3-1.3-1.8-1.51.10.81.01.0-1.91.3-0.3
Breakpoint value in progressive ratio session1.01.93.41.11.61.6-1.6-1.4-1.51.81.21.41.4-1.11.2-0.6
Number of licking bursts0.00.10.2-0.10.20.2-0.2-0.3-0.2-0.10.20.40.4-0.5-0.2-0.1
Context. condit. distance diff. score0.30.40.8-0.4-0.9-0.90.90.70.8-0.4-0.5-0.0-0.0-0.6-0.7-0.2
Locomotion velocity, session 10.10.20.9-0.4-0.3-0.30.30.30.20.20.30.40.40.40.2-0.9
Locomotion distance, session 10.60.82.00.50.40.4-0.4-0.6-0.60.90.91.21.2-1.00.7-1.4
Locomotion velocity, session 22.32.83.91.51.71.7-1.7-1.8-1.72.01.61.81.8-1.51.5-1.4
Locomotion distance, session 20.20.30.9-0.30.30.3-0.3-0.3-0.40.60.60.90.9-0.5-0.1-0.9
Locomotion velocity, session 30.60.71.70.90.40.4-0.4-0.8-0.70.50.70.90.9-1.30.8-1.1
Locomotion distance, session 30.10.20.60.00.30.3-0.3-0.3-0.30.10.60.40.40.20.7-0.8
Stereotopy head waving bouts, day 30.30.32.10.0-0.6-0.60.60.10.3-0.2-0.40.20.2-1.4-0.8-0.0
Stereotopy head waving duration, day 30.30.31.4-0.4-0.6-0.60.60.20.4-0.1-0.40.40.4-1.2-0.9-0.1
Locomotion velocity, session 70.20.22.30.2-0.2-0.20.2-0.10.10.1-0.20.40.4-1.5-0.70.1
Locomotion distance, session 70.10.10.4-0.4-0.3-0.30.30.10.2-0.20.20.20.2-0.4-0.4-0.6
Stereotopy head waving bouts, day 70.30.31.31.00.40.4-0.4-0.6-0.50.6-0.00.50.5-1.10.10.3
Stereotopy head waving duration, day 71.51.82.41.51.41.4-1.4-1.5-1.51.51.11.41.4-1.51.0-0.7
Locomotion velocity, session 80.20.31.3-1.2-0.4-0.40.40.60.40.00.20.40.40.1-0.6-0.7
Locomotion distance, session 80.30.41.1-0.2-0.9-0.90.90.50.7-0.4-0.60.00.0-1.0-0.9-0.0
Degree of sensitization distance0.10.11.30.5-0.2-0.20.2-0.2-0.0-0.1-0.10.10.1-1.1-0.3-0.1
Degree of sensitization stereotypy0.91.02.41.51.11.1-1.1-1.2-1.11.30.50.80.8-1.20.60.0
Conditioned locomotion0.50.60.80.40.90.9-0.9-0.9-0.80.80.80.90.9-0.70.3-0.7
Cocaine response after cond. corrected0.50.81.4-1.2-1.2-1.21.21.21.1-0.7-0.4-0.1-0.10.9-0.7-0.4
Cocaine response after cond. not corrected0.30.51.1-0.5-0.9-0.90.90.90.8-0.6-0.4-0.4-0.41.0-0.1-0.2
Cocaine response before conditioning0.60.72.51.60.90.9-0.9-0.8-0.80.70.3-0.4-0.40.11.40.4
Saline control response3.04.25.81.12.22.2-2.2-2.0-2.22.12.42.22.2-0.72.2-2.1
Bone: connectivity density1.93.04.82.21.71.7-1.7-2.0-1.81.61.51.51.5-1.81.8-1.4
Bone: cortical apparent density0.10.20.7-0.00.40.4-0.4-0.1-0.30.70.40.90.9-0.10.2-0.2
Bone: cortical area1.01.73.21.81.41.4-1.4-1.6-1.41.21.00.90.9-1.51.3-0.4
Bone: cortical porosity0.20.21.3-0.8-0.2-0.20.20.50.40.1-0.40.10.10.2-1.10.6
Bone: cortical porosity0.10.10.6-0.70.00.0-0.00.20.10.3-0.00.40.40.1-0.80.1
Bone: cortical thickness2.84.76.60.92.52.5-2.5-2.0-2.32.42.62.32.3-0.72.1-2.0
Bone: cortical thickness0.40.51.2-0.20.60.6-0.6-0.3-0.50.61.00.80.80.50.7-1.1
Bone: cortical tissue density0.20.31.10.00.60.6-0.6-0.2-0.40.90.51.01.0-0.20.3-0.3
Condit. Reinf. active minus inactive responses0.91.01.51.21.01.0-1.0-1.1-1.11.20.90.90.9-0.71.2-0.8
Condit. Reinf. active-inactive response ratio0.30.30.50.40.50.5-0.5-0.3-0.40.70.50.70.7-0.00.6-0.6
Condit. Reinf. active responses0.81.13.21.81.01.0-1.0-1.2-1.11.10.60.60.6-1.31.1-0.3
Condit. Reinf. inactive responses0.30.31.71.30.10.1-0.1-0.4-0.2-0.0-0.4-0.6-0.6-0.90.30.7
Incentive salience index mean1.31.73.01.71.31.3-1.3-1.4-1.31.31.11.11.1-1.11.7-1.0
Condit. Reinf. lever presses1.11.73.71.91.31.3-1.3-1.5-1.41.11.11.01.0-1.11.8-0.9
Condit. Reinf. active minus inactive responses0.20.21.30.3-0.3-0.30.30.20.3-0.2-0.7-0.5-0.5-0.4-0.51.1
Condit. Reinf. active-inactive response ratio0.61.03.30.7-0.7-0.70.70.30.6-0.5-1.4-0.9-0.9-1.3-1.31.8
Condit. Reinf. active responses0.10.10.30.50.40.4-0.4-0.4-0.40.40.20.30.3-0.40.40.1
Condit. Reinf. inactive responses0.40.62.1-0.20.60.6-0.6-0.3-0.50.51.10.70.71.01.4-1.2
Condit. Reinf. lever presses1.01.53.51.91.41.4-1.4-1.5-1.41.11.00.70.7-1.01.5-0.5
Condit. Reinf. lever reinforcers received0.20.30.50.70.60.6-0.6-0.6-0.50.70.40.50.5-0.60.50.1
Conditioned reinforcement - actives0.20.82.50.7-0.7-0.70.80.60.8-0.2-1.3-1.1-1.10.4-0.51.6
Conditioned reinforcement - inactives0.20.42.11.5-0.4-0.40.40.00.3-0.1-0.9-0.7-0.70.10.21.1
Conditioned locomotion2.02.94.6-0.4-2.1-2.12.11.71.9-1.3-2.1-1.7-1.70.8-1.71.4
Patch foraging indifference point 0 sec0.41.01.50.70.90.9-0.9-1.0-1.01.01.01.21.2-1.10.9-0.9
Patch foraging indifference point AUC0.61.52.51.61.41.4-1.4-1.4-1.31.40.70.90.9-1.60.80.4
Delay disc. indifference point, 0s delay0.20.20.5-0.5-0.7-0.70.70.40.5-0.5-0.2-0.3-0.30.70.1-0.4
Delay disc. indifference point, 16s delay0.10.20.70.80.30.3-0.3-0.5-0.40.40.20.20.2-0.70.2-0.1
Delay disc. indifference point, 2s delay0.20.20.30.3-0.5-0.50.50.20.4-0.4-0.5-0.6-0.60.20.10.3
Delay disc. indifference point, 24s delay0.10.20.8-0.10.30.3-0.3-0.2-0.30.30.60.50.50.10.6-0.9
Delay disc. indifference point, 4s delay0.50.52.0-0.20.40.4-0.4-0.5-0.60.41.01.01.0-0.30.8-1.4
Delay disc. indifference point, 8s delay0.20.41.7-1.3-0.7-0.70.70.70.6-0.6-0.2-0.1-0.10.5-0.7-0.3
Indifference point function ln k1.44.26.6-2.3-2.5-2.52.52.42.3-2.4-1.3-1.5-1.52.6-0.9-0.4
Indifference point function log k1.44.26.6-2.3-2.5-2.52.52.42.3-2.4-1.3-1.5-1.52.6-0.9-0.4
Patch foraging total patch changes 0 sec0.41.01.70.30.90.9-0.9-0.9-1.01.01.21.31.3-0.71.1-1.2
Patch foraging total patch changes 12 sec5.47.29.92.13.03.0-3.0-2.8-2.93.12.52.92.9-2.71.9-1.5
Patch foraging total patch changes 18 sec0.30.82.10.71.01.0-1.0-0.9-0.91.00.70.90.9-1.50.1-0.0
Patch foraging total patch changes 24 sec2.58.610.02.53.03.0-3.0-3.1-3.13.02.93.23.2-3.02.7-2.2
Patch foraging total patch changes 6 sec1.22.12.91.11.41.4-1.4-1.5-1.41.41.41.71.7-1.51.5-1.3
Patch foraging time to switch 0 sec0.20.62.41.50.60.6-0.6-1.0-0.70.90.10.30.3-1.20.00.1
Patch foraging water rate 0 sec0.20.71.8-1.1-0.8-0.80.81.00.9-1.1-0.4-0.5-0.51.3-0.40.1
Patch foraging water rate 12 sec0.62.55.8-2.4-1.7-1.71.71.91.7-2.0-0.7-1.2-1.22.2-0.4-0.2
Patch foraging water rate 18 sec0.40.82.8-1.3-0.7-0.70.70.70.6-1.00.3-0.2-0.21.70.6-1.3
Patch foraging water rate 24 sec1.21.83.2-1.7-1.5-1.51.41.61.5-1.6-0.9-1.0-1.01.8-0.80.2
Patch foraging water rate 6 sec1.21.84.9-2.2-1.4-1.41.41.61.5-1.7-0.6-0.8-0.81.6-0.7-0.3
Seeking ratio, delayed vs. immediate footshock0.10.10.50.20.30.3-0.3-0.3-0.30.10.30.20.20.70.6-0.4
Distance traveled before self-admin1.43.05.92.41.81.8-1.8-1.9-1.81.71.21.41.4-2.21.5-0.5
Distance traveled after self-admin0.20.40.70.60.70.7-0.7-0.6-0.60.80.50.60.6-0.80.6-0.2
Extensor digitorum longus weight6.325.030.04.35.45.4-5.4-5.4-5.54.95.25.25.2-3.64.8-4.3
Bone: elastic displacement0.50.62.4-1.6-0.6-0.60.60.90.8-0.6-0.2-0.4-0.41.0-1.1-0.0
Bone: elastic work0.91.22.9-0.11.11.1-1.1-0.9-1.01.11.51.21.2-0.40.5-1.7
Bone: endosteal estimation0.71.62.60.9-1.4-1.41.40.51.0-1.5-1.6-1.6-1.6-1.0-0.81.2
Bone: endosteal perimeter1.12.85.31.0-1.7-1.71.70.81.4-1.9-2.3-2.1-2.1-1.1-1.02.1
Epididymis fat weight0.31.63.70.8-1.1-1.11.10.50.8-1.7-1.6-1.9-1.9-0.3-0.71.7
Delta time in closed arm before/after self-admin1.51.44.5-0.50.80.8-0.8-0.8-0.91.11.61.51.5-1.10.6-2.1
Delta time in open arm before/after self-admin1.51.74.82.21.41.4-1.4-1.5-1.31.60.71.01.0-1.51.00.1
Diff in mean of infusions in LGA sessions1.32.33.80.81.61.6-1.6-1.3-1.51.81.62.02.0-0.81.6-1.3
Delay discount exponential model param0.10.10.5-0.0-0.1-0.10.10.30.3-0.3-0.4-0.5-0.50.2-0.40.7
Extinction: sum of active levers before priming2.64.04.52.12.12.1-2.1-2.1-2.12.11.82.12.1-1.92.0-1.5
Active lever presses in extinction session 62.42.44.82.21.71.7-1.7-1.7-1.61.91.11.31.3-1.41.6-0.4
Bone: final force1.83.05.12.31.81.8-1.8-2.0-1.81.61.51.41.4-2.01.8-1.1
Bone: final moment1.93.15.02.21.81.8-1.8-2.1-1.91.61.51.51.5-2.01.8-1.2
Food consumed during 24 hour testing period0.10.10.40.10.00.0-0.0-0.10.1-0.4-0.2-0.5-0.50.6-0.10.5
Glucose1.72.64.8-1.0-1.9-1.91.91.51.7-2.2-1.7-1.8-1.80.5-1.31.0
Heart weight0.10.20.9-0.3-0.5-0.50.50.10.2-0.80.1-0.3-0.3-0.20.2-0.9
Delay discount hyperbolic model param0.00.10.3-0.1-0.0-0.00.00.20.2-0.2-0.3-0.3-0.30.2-0.30.5
Intermittent access intake day 1-15 change0.52.55.3-0.5-1.4-1.41.41.41.5-1.3-1.9-1.9-1.91.7-1.22.3
Intermittent access intake escalation0.63.16.5-0.5-1.6-1.61.61.61.7-1.5-2.1-2.1-2.11.8-1.42.6
Intermittent access intake escalation 20.61.03.40.2-0.7-0.70.80.70.8-0.5-1.3-1.3-1.30.9-0.71.9
Intermitt. access day 1 inactive lever presses0.11.72.9-0.9-1.3-1.31.31.31.3-0.9-1.6-1.4-1.41.0-1.21.7
Intermitt. access day 15 inactive lever presses0.21.15.52.30.80.8-0.8-1.2-1.01.10.30.20.2-1.01.50.3
Intermitt. access escalation Index0.30.82.1-1.3-0.9-0.90.91.00.9-0.9-0.6-0.7-0.71.5-0.50.2
Intermittent access day 1 total infusions0.20.61.81.4-0.9-0.90.90.10.5-0.3-0.9-0.9-0.9-0.6-0.40.4
Intermittent access day 15 total infusions1.94.67.50.2-2.3-2.32.31.82.1-1.8-2.7-2.7-2.71.4-1.62.5
Intermittent access terminal intake (last 3 days)1.01.73.21.5-1.3-1.31.30.61.0-0.7-1.8-1.7-1.70.1-0.91.8
Intermittent access total infusions1.31.52.81.1-1.4-1.41.40.71.1-0.7-1.7-1.5-1.5-0.1-1.01.3
Intermittent access day 1 locomotion0.10.31.31.1-0.5-0.50.5-0.10.30.1-0.5-0.3-0.3-0.9-0.30.0
Intermittent access day 15 total locomotion0.20.72.81.7-0.7-0.70.70.20.5-0.0-1.2-0.9-0.9-0.4-0.41.2
Intermittent access total locomotion0.91.06.02.5-0.8-0.80.8-0.10.4-0.0-1.3-1.0-1.0-0.7-0.41.2
Intermittent access standard deviation0.31.42.3-0.2-1.2-1.21.21.11.2-0.8-1.5-1.5-1.50.3-1.11.5
Left kidney weight0.00.40.70.8-0.5-0.50.50.00.3-0.7-0.8-0.8-0.8-0.6-0.30.7
Right kidney weight0.00.20.40.6-0.2-0.20.2-0.10.1-0.6-0.6-0.6-0.6-0.4-0.20.6
Cocaine induced anxiety0.00.00.30.30.10.1-0.1-0.1-0.10.3-0.1-0.1-0.1-0.20.00.5
Post-drug Anxiety0.30.31.00.70.60.6-0.6-0.6-0.60.60.40.40.40.11.0-0.1
Baseline Anxiety0.40.61.60.10.60.6-0.6-0.6-0.70.50.90.90.90.11.0-1.3
Tail length0.31.52.5-0.41.41.4-1.4-1.1-1.30.91.61.51.5-0.00.8-1.3
Length with tail1.46.48.21.42.92.9-2.9-2.6-2.82.32.82.82.8-0.92.7-2.2
Length without tail1.89.713.72.13.33.3-3.3-3.2-3.42.93.33.53.5-1.33.7-2.8
Times rat made contact with spout0.30.30.7-0.70.40.4-0.4-0.2-0.30.40.80.70.70.60.2-0.8
Lifetime Intake0.91.11.90.7-1.3-1.31.30.71.1-0.6-1.4-1.3-1.3-0.0-0.90.8
Liver weight, left1.01.72.4-1.4-1.3-1.31.31.31.3-1.5-1.1-1.3-1.31.5-1.21.0
Liver weight, right1.01.73.0-1.3-1.5-1.51.51.41.4-1.7-0.9-1.2-1.21.5-0.60.2
Locomotor activity0.91.45.3-2.3-1.1-1.11.11.31.1-1.1-0.2-0.6-0.61.9-0.5-0.6
Locomotor testing distance0.61.54.7-2.2-1.2-1.21.21.41.2-1.2-0.1-0.7-0.72.0-0.4-0.8
Locomotor testing rearing0.41.43.8-1.8-1.2-1.21.21.31.2-1.3-0.4-1.0-1.01.9-0.3-0.3
Locomotion in novel chamber1.82.43.5-0.4-1.7-1.71.71.41.6-1.4-1.9-1.9-1.90.6-1.71.6
Locomotion in novel chamber post-restriction1.03.15.7-1.2-1.9-1.91.91.81.9-1.5-2.1-1.6-1.60.5-2.42.0
Fecal boli incidents, locomotor time 10.20.52.30.6-0.4-0.40.40.30.4-0.4-1.0-0.9-0.90.1-0.71.5
Change in fecal boli incidents, locomotor task1.01.12.5-1.6-1.2-1.21.21.21.1-1.2-0.5-0.5-0.51.4-0.5-0.2
Time >=10cm from walls, locomotor time 11.72.24.80.5-1.4-1.41.41.01.3-1.3-2.1-1.7-1.70.5-1.42.2
Bouts of movement, locomotor time 10.10.20.7-0.50.30.3-0.30.2-0.00.7-0.10.20.20.8-0.50.6
Total resting periods, locomotor time 10.10.10.5-0.20.30.3-0.30.0-0.10.6-0.10.10.10.5-0.30.7
Rest time, locomotor task time 11.21.92.3-1.2-1.3-1.31.31.41.4-1.5-1.4-1.5-1.50.7-1.51.5
Distance moved, locomotor task time 10.10.40.90.80.60.6-0.6-0.7-0.70.60.60.50.5-0.10.9-0.7
Vertical activity count, locomotor time 10.10.51.3-0.6-0.8-0.80.80.70.8-0.8-0.6-0.6-0.61.1-0.40.3
Time >=10cm from walls, locomotor time 20.10.31.60.6-0.1-0.10.10.10.2-0.1-0.8-0.6-0.60.2-0.31.3
Bouts of movement, locomotor time 20.41.21.80.91.31.3-1.3-1.2-1.21.31.11.01.0-0.90.9-0.8
Total resting periods, locomotor time 20.10.60.80.70.90.9-0.9-0.8-0.80.90.70.60.6-0.80.5-0.4
Rest time, locomotor task time 22.13.54.5-1.8-2.0-2.02.02.02.0-2.0-1.9-1.7-1.71.2-2.11.5
Distance moved, locomotor task time 20.30.50.90.40.80.8-0.8-0.6-0.71.00.80.50.5-0.10.8-0.5
Vertical activity count, locomotor time 20.10.21.2-1.1-0.1-0.10.10.40.2-0.10.30.10.11.00.0-0.4
Light reinforcement 10.00.10.7-0.2-0.0-0.00.00.20.1-0.20.0-0.3-0.30.90.70.2
Light reinforcement 20.30.62.71.4-0.1-0.10.1-0.10.1-0.3-1.0-1.0-1.0-0.60.01.7
Bone: marrow area0.81.93.00.7-1.5-1.51.50.71.2-1.7-1.7-1.7-1.7-0.9-1.01.2
Bone: maximum diameter0.30.63.01.70.50.5-0.5-0.9-0.60.4-0.10.10.1-1.50.50.5
Bone: maximum force2.75.311.43.42.32.3-2.3-2.8-2.52.01.71.61.6-3.12.2-1.2
Bone: maximum moment2.85.310.73.32.32.3-2.3-2.8-2.52.01.81.61.6-3.02.1-1.3
Mean time between licks in bursts0.21.04.2-0.50.60.6-0.6-0.4-0.60.41.60.80.81.01.2-2.1
Mean num. licks in bursts0.10.21.0-0.7-0.3-0.30.30.50.40.00.0-0.2-0.21.0-0.1-0.2
Cd content in liver1.01.12.3-0.2-1.1-1.11.10.91.1-0.8-1.4-0.8-0.8-0.1-1.51.4
Co content in liver1.21.54.9-2.1-1.1-1.11.11.51.2-0.9-0.5-0.5-0.52.2-0.70.0
Cu content in liver0.00.10.3-0.6-0.2-0.20.20.30.2-0.0-0.10.00.00.4-0.3-0.1
Fe content in liver0.00.00.1-0.2-0.3-0.30.30.30.3-0.1-0.30.00.0-0.2-0.20.0
K content in liver0.80.81.80.90.90.9-0.9-1.0-0.90.60.90.60.6-1.01.3-0.8
Mg content in liver0.20.20.70.20.10.1-0.1-0.3-0.30.10.50.50.5-0.60.8-0.9
Mn content in liver3.33.74.82.02.12.1-2.1-2.2-2.11.91.71.81.8-1.92.0-1.0
Na content in liver0.60.71.81.20.80.8-0.8-0.9-0.90.70.70.50.5-1.11.3-0.4
Rb content in liver2.12.44.1-2.0-1.7-1.71.71.71.6-1.8-1.2-1.4-1.41.7-1.10.6
Se content in liver0.30.32.31.00.40.4-0.4-0.6-0.40.3-0.1-0.0-0.0-1.5-0.10.5
Sr content in liver3.83.34.61.42.02.0-2.0-1.9-2.02.21.82.12.1-1.21.4-1.1
Zn content in liver2.42.84.31.31.61.6-1.6-1.7-1.71.91.62.12.1-1.81.1-1.4
Bone: minimum diameter0.40.91.61.3-0.7-0.70.7-0.00.5-1.0-1.1-1.2-1.2-1.2-0.41.0
Time in familiar zone, hab. session 10.10.10.60.80.20.2-0.2-0.4-0.30.30.30.10.1-0.10.7-0.4
Time in novel zone, hab. session 11.21.42.3-1.5-1.2-1.21.21.31.3-1.3-0.8-1.0-1.01.4-0.80.5
Total zone transitions, hab. session 10.20.31.00.10.50.5-0.5-0.4-0.50.60.41.01.0-0.40.4-0.4
Total locomotion distance, hab. session 10.10.21.10.4-0.4-0.40.40.10.2-0.1-0.60.10.1-1.1-0.30.5
Locomotion velocity, hab. session 10.20.31.80.60.30.3-0.2-0.4-0.30.5-0.00.70.7-1.3-0.00.1
Time in familiar zone, hab. session 20.60.75.7-0.9-0.3-0.30.30.60.4-0.70.1-0.7-0.72.40.5-0.3
Time in novel zone, hab. session 20.60.73.70.90.60.6-0.6-0.8-0.70.80.40.80.8-1.90.2-0.4
Total zone transitions, hab. session 21.52.03.11.21.21.2-1.2-1.4-1.31.31.51.61.6-0.81.8-1.7
Total locomotion distance, hab. session 20.20.30.60.60.30.3-0.3-0.5-0.40.40.40.70.7-0.70.8-0.7
Locomotion velocity, hab. session 20.10.20.80.70.10.1-0.1-0.4-0.30.20.10.50.5-0.90.5-0.3
Novel to familiar place preference ratio1.52.03.31.41.61.6-1.6-1.7-1.61.41.11.21.2-1.81.0-0.5
Novelty place preference1.01.22.31.21.31.3-1.3-1.4-1.31.00.80.90.9-1.50.7-0.3
Time in novel zone, NPP test1.11.32.51.11.31.3-1.3-1.4-1.31.10.90.90.9-1.60.7-0.4
Total zone transitions, NPP test1.01.52.90.71.11.1-1.1-1.1-1.11.41.31.71.7-1.20.7-1.4
Total locomotion distance, NPP test0.10.20.5-0.0-0.0-0.0-0.0-0.1-0.10.40.20.70.7-0.7-0.2-0.6
Locomotion velocity, NPP test0.10.10.4-0.2-0.1-0.10.10.00.10.30.00.60.6-0.6-0.4-0.3
Intraocular pressure0.20.30.7-0.6-0.3-0.30.30.50.4-0.4-0.5-0.5-0.50.8-0.60.6
Delta distance traveled before/after self-admin0.70.82.8-1.7-0.8-0.80.81.10.9-0.8-0.3-0.3-0.31.7-0.1-0.3
Delta ambulatory time before/after self-admin0.71.23.8-2.0-1.0-1.01.01.31.1-1.0-0.5-0.5-0.51.9-0.5-0.1
Parametrial fat weight1.12.74.80.3-1.7-1.71.71.01.4-1.8-2.2-2.1-2.1-0.3-1.52.1
Pavlov. Cond. lever latency1.11.43.0-1.7-1.2-1.21.21.41.3-1.1-1.0-0.9-0.91.0-1.30.7
Pavlov. Cond. magazine entry latency1.31.65.92.41.31.3-1.3-1.5-1.31.20.70.50.5-1.41.3-0.1
Pavlov. Cond. change in total contacts0.60.63.31.80.70.7-0.7-0.9-0.70.7-0.00.20.2-1.10.50.6
Pavlov. Cond. index score0.81.03.11.81.11.1-1.1-1.2-1.11.00.60.50.5-0.91.0-0.1
Pavlov. Cond. latency score0.70.92.81.71.01.0-1.0-1.1-1.00.90.70.50.5-0.71.1-0.3
Pavlov. Cond. lever contacts0.60.82.21.50.80.8-0.8-1.1-0.90.70.70.50.5-0.81.1-0.5
Pavlov. Cond. magazine entry number0.81.02.9-1.7-1.1-1.11.11.21.1-1.1-0.6-0.5-0.50.8-0.9-0.1
Pavlov. Cond. intertrial magazine entries0.10.10.60.00.10.1-0.10.0-0.00.3-0.3-0.3-0.3-0.3-0.60.7
Pavlov. Cond. lever-magazine prob. diff.0.91.13.51.91.11.1-1.1-1.3-1.11.00.60.50.5-1.00.90.0
Pavlov. Cond. response bias1.01.33.92.01.31.2-1.2-1.4-1.21.20.70.60.6-1.01.1-0.1
Pavlov. Cond. lever latency0.60.92.5-1.6-1.0-1.01.01.11.0-0.8-0.7-0.4-0.40.5-1.30.4
Pavlov. Cond. magazine entry latency4.05.78.02.82.72.7-2.6-2.6-2.62.82.21.91.9-1.42.6-1.4
Pavlov. Cond. change in total contacts0.92.26.92.61.61.6-1.6-1.8-1.61.50.90.70.7-1.11.9-0.1
Pavlov. Cond. index score2.33.68.22.92.12.1-2.1-2.2-2.12.11.51.11.1-1.42.2-0.7
Pavlov. Cond. latency score2.03.38.02.82.02.0-2.0-2.1-2.02.01.31.11.1-1.52.0-0.6
Pavlov. Cond. lever contacts0.50.72.31.50.90.9-0.9-1.0-0.90.80.60.20.2-0.31.2-0.2
Pavlov. Cond. magazine entry number6.68.612.0-3.5-3.3-3.33.33.23.2-3.4-2.6-2.4-2.42.1-3.01.6
Pavlov. Cond. intertrial magazine entries1.02.33.4-1.4-1.6-1.61.61.61.6-1.5-1.7-1.2-1.20.5-1.81.6
Pavlov. Cond. lever-magazine prob. diff.2.64.08.83.02.22.2-2.2-2.3-2.22.21.61.21.2-1.42.3-0.8
Pavlov. Cond. response bias2.12.95.32.31.91.9-1.9-1.9-1.91.71.51.11.1-0.92.2-1.0
Time in closed arm before self-admin0.10.20.80.90.00.0-0.0-0.2-0.0-0.1-0.5-0.6-0.60.00.10.8
Time in closed arm after self-admin0.60.61.3-1.1-0.8-0.80.80.80.7-0.9-0.5-0.9-0.91.0-0.60.2
Time in open arm before self-admin1.21.56.8-2.6-1.2-1.21.21.41.2-1.3-0.1-0.1-0.11.2-1.0-1.1
Time in open arm after self-admin0.40.41.3-0.00.40.4-0.4-0.3-0.30.60.61.11.1-1.1-0.2-0.9
Bone: periosteal estimation0.30.63.51.90.10.1-0.1-0.8-0.4-0.2-0.4-0.4-0.4-1.80.30.6
Bone: periosteal perimeter0.20.42.41.60.20.2-0.2-0.6-0.3-0.1-0.4-0.3-0.3-1.10.60.7
Bone: post-yield work0.61.16.02.5-0.2-0.20.2-0.6-0.1-0.2-0.8-0.7-0.7-2.20.00.9
Progressive ratio test 1 active lever presses0.40.61.20.2-1.0-1.01.00.70.9-0.3-1.1-0.8-0.8-0.2-1.00.7
Progressive ratio test 1 breakpoint0.40.61.20.2-1.0-1.01.00.70.9-0.3-1.1-0.8-0.8-0.2-0.90.8
Progressive ratio test 1 inactive lever presses0.30.71.51.20.70.7-0.7-0.9-0.81.10.60.60.6-0.90.8-0.5
Progressive ratio test 2 active lever presses1.01.42.80.8-1.3-1.31.30.81.1-0.5-1.7-1.4-1.4-0.1-0.91.6
Progressive ratio test 2 breakpoint1.01.32.60.9-1.2-1.21.20.81.1-0.5-1.6-1.4-1.4-0.1-0.91.5
Progressive ratio test 2 inactive lever presses0.31.02.31.1-0.9-0.90.90.50.8-0.4-1.4-1.3-1.30.1-0.41.5
Incentive Sensitization - Responses0.30.94.52.10.70.7-0.7-1.1-0.91.00.30.30.3-1.21.00.1
Incentive Sensitization - Breakpoint0.30.74.32.10.60.6-0.6-0.9-0.70.80.20.20.2-1.10.90.2
Sum of active levers in priming session hrs 5-60.80.71.91.41.01.0-0.9-0.8-0.81.10.00.30.3-0.70.61.1
Progressive ratio0.00.11.31.10.10.1-0.1-0.4-0.2-0.0-0.2-0.3-0.3-0.10.00.3
Food seeking constrained by brief footshock0.10.11.1-0.3-0.2-0.20.20.20.2-0.1-0.0-0.0-0.01.10.4-0.2
Seeking ratio, punishment vs. effort0.10.31.8-1.4-0.2-0.20.20.50.2-0.10.40.40.40.60.3-0.8
Retroperitoneal fat weight2.812.817.1-2.4-4.0-4.04.03.43.7-4.1-3.8-4.0-4.02.2-3.42.8
Reaction time number correct0.30.92.60.21.01.0-1.0-0.9-1.00.41.30.70.7-0.11.6-1.2
Reaction time mean minus median0.10.51.31.10.80.8-0.8-0.7-0.70.9-0.10.20.2-0.3-0.11.1
Reaction time mean minus median AUC0.00.10.80.10.40.4-0.4-0.1-0.30.4-0.1-0.0-0.00.5-0.20.9
Reaction time num false alarms0.40.83.4-1.9-0.8-0.80.81.10.9-0.6-0.0-0.0-0.00.9-0.6-0.8
Reaction time num false alarms AUC0.20.53.1-1.8-0.3-0.30.30.70.4-0.10.50.60.60.6-0.3-1.2
Reaction time trials correct on left0.30.92.60.21.01.0-1.0-0.9-1.00.41.30.70.7-0.11.6-1.2
Reaction time trials on left0.30.92.60.21.11.1-1.1-0.9-1.00.51.30.70.7-0.11.6-1.2
Reaction time mean0.10.31.50.5-0.3-0.30.30.40.30.1-0.9-0.6-0.60.5-0.51.2
Reaction time mean AUC0.20.41.70.5-0.3-0.30.30.40.4-0.1-1.0-0.8-0.80.6-0.31.3
Median of all reaction times0.10.20.70.6-0.3-0.30.30.30.30.1-0.8-0.4-0.40.3-0.30.8
Reaction time omissions0.10.20.60.20.60.6-0.6-0.3-0.50.80.30.50.50.40.20.2
Reaction time false alarm rate0.50.72.4-1.5-0.9-0.90.91.10.9-0.4-0.30.00.00.7-1.1-0.4
Reaction time premature initiation rate4.56.910.41.82.62.6-2.6-2.6-2.82.33.22.72.7-1.43.1-3.2
Reaction time premature initiations2.98.713.91.53.13.1-3.1-2.8-3.12.53.72.92.9-1.43.6-3.5
Std. dev. reaction times0.10.42.3-0.0-0.3-0.30.30.50.40.1-1.0-0.5-0.50.6-1.01.5
Reaction time trials completed0.30.92.60.21.11.1-1.1-0.9-1.00.51.30.70.7-0.11.6-1.2
Reaction time trials AUC0.20.82.50.20.90.9-0.9-0.8-0.90.41.20.60.6-0.01.6-1.2
Run reversals in cocaine runway, females0.60.73.30.30.50.5-0.5-0.7-0.60.41.01.11.1-0.00.7-1.8
Run reversals in cocaine runway, males0.40.51.1-1.1-0.7-0.70.70.90.8-0.7-0.6-0.3-0.30.6-0.70.5
Latency to leave start box in cocaine runway0.20.30.60.2-0.6-0.60.60.30.5-0.7-0.6-0.8-0.80.4-0.00.4
Latency to leave start box in cocaine runway, F0.10.10.70.40.20.2-0.2-0.4-0.30.20.30.10.10.10.8-0.2
Latency to leave start box in cocaine runway, M1.91.82.5-0.7-1.5-1.51.51.31.4-1.6-1.4-1.5-1.50.7-1.31.0
Std. dev. time between licks in bursts0.30.63.8-1.0-0.2-0.20.20.40.2-0.40.6-0.1-0.12.00.7-1.1
Total sessions with >9 infusions0.80.91.4-0.3-1.2-1.21.21.01.1-0.7-1.1-1.1-1.10.4-1.00.6
Short access day 1 total inactive lever presses0.10.10.30.4-0.5-0.50.50.20.4-0.2-0.4-0.1-0.1-0.1-0.5-0.2
Short access day 10 total inactive lever presses0.10.81.1-1.1-0.9-0.90.91.01.0-1.0-0.8-0.7-0.70.6-1.00.5
Short access day 1 total infusions0.71.52.1-0.5-1.5-1.51.51.11.4-1.1-1.3-1.3-1.30.9-1.30.7
Short access day 10 total infusions0.20.41.01.0-0.7-0.70.70.20.5-0.3-0.8-0.7-0.7-0.4-0.30.2
Short access total infusions0.40.61.20.0-1.1-1.11.10.70.9-0.6-0.9-0.8-0.80.1-0.80.1
Short access day 1 locomotion0.30.40.90.3-0.8-0.80.80.50.7-0.4-0.8-0.7-0.7-0.2-1.00.5
Short access day 10 total locomotion0.10.32.31.5-0.1-0.10.1-0.4-0.10.3-0.30.00.0-0.80.30.1
Short access total locomotion0.20.30.91.0-0.6-0.60.60.20.4-0.1-0.8-0.5-0.5-0.6-0.50.4
One hour access (0.3 mA shock)1.11.32.50.6-1.3-1.31.30.91.2-0.9-1.6-1.4-1.40.2-0.91.3
Compulsive drug intake0.81.22.4-0.81.21.2-1.2-0.8-1.00.61.51.31.3-0.10.6-1.5
One hour access (shock baseline)1.64.27.40.4-2.3-2.32.31.72.1-1.6-2.7-2.5-2.50.7-1.72.5
Social response proportion0.20.20.6-0.00.50.5-0.5-0.4-0.50.30.6-0.0-0.00.80.8-0.4
Social responses0.10.20.5-0.70.40.4-0.4-0.2-0.30.30.60.20.20.70.3-0.4
Social time0.10.21.4-1.20.00.0-0.00.30.10.10.20.30.30.7-0.1-0.2
Soleus weight2.78.010.0-2.5-3.2-3.23.23.13.1-3.0-2.8-2.8-2.82.1-2.72.0
Bone: stiffness0.81.44.52.11.21.2-1.2-1.4-1.20.90.50.50.5-1.61.20.1
Tibialis anterior weight8.228.234.64.25.95.9-5.9-5.7-5.85.75.25.85.8-4.44.2-3.8
Time to tail flick, vehicle, before self-admin0.20.31.41.10.30.3-0.3-0.6-0.40.40.10.20.2-1.20.1-0.1
Time to tail flick, vehicle, after self-admin0.20.40.90.60.50.5-0.5-0.6-0.60.60.70.70.7-0.70.9-1.0
Time to tail flick, test, before self-admin0.50.51.80.70.30.3-0.3-0.6-0.50.20.70.90.9-1.30.2-1.3
Time to tail flick, test, after self-admin0.10.10.30.60.30.3-0.3-0.3-0.20.1-0.1-0.1-0.1-0.4-0.40.4
Delta time to tail flick, vehicle, before/after SA0.30.30.7-0.00.50.5-0.5-0.4-0.50.50.70.70.70.10.6-0.8
Delta time to tail flick, test, before/after SA0.20.21.5-0.10.20.2-0.20.10.00.2-0.4-0.5-0.50.3-0.41.2
Tibia length1.54.18.72.92.12.1-2.1-2.3-2.12.11.01.71.7-2.71.60.1
Ambulatory time before self-admin0.82.46.12.51.61.6-1.6-1.7-1.61.60.91.11.1-1.91.5-0.2
Ambulatory time after self-admin0.10.20.80.90.40.4-0.4-0.4-0.40.60.10.20.2-0.40.80.2
Bone: tissue strength0.20.20.7-0.6-0.3-0.30.30.40.3-0.8-0.0-0.6-0.60.70.2-0.0
Total heroin consumption4.85.67.41.52.72.7-2.7-2.3-2.52.72.42.72.7-1.91.8-1.5
Bone: trabecular number1.12.04.02.01.31.3-1.3-1.7-1.51.21.11.21.2-1.81.4-1.0
Bone: trabecular spacing0.71.04.0-1.6-0.8-0.80.81.10.9-0.8-0.3-0.8-0.82.0-0.40.1
Bone: trabecular thickness0.20.30.80.5-0.4-0.40.40.20.4-0.5-0.8-0.6-0.6-0.2-0.40.9
Bone: trabecular tissue density4.57.910.9-2.9-3.0-3.03.03.33.1-2.7-2.8-2.5-2.52.5-2.72.3
Water consumed over 24 hours0.50.91.60.21.11.1-1.1-0.8-1.00.71.31.01.00.31.1-1.1
Number of responses in last shaping day0.20.20.7-0.40.30.3-0.3-0.2-0.30.70.50.60.6-0.1-0.2-0.8