Hub : Genes

Tut1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Tut1 0.13 0.1 2.6e-04 0.01 0.03 0.03 0.02 8.7e-03 1.7e-04 6.1e-04 1.5e-03
2 RMTg alternative TSS NM_001033901.1 0.36 0.14 6.6e-10 0.25 0.24 0.24 0.26 2.2e-07 5.5e-07 5.4e-07 1.2e-07
3 RMTg alternative TSS NM_001033901.1 0.23 0.12 4.7e-06 0.14 0.13 0.13 0.15 1.1e-04 2.2e-04 2.7e-04 1.0e-04
4 RMTg alternative TSS XM_063271615.1 0.36 0.14 6.0e-10 0.26 0.24 0.24 0.26 1.6e-07 5.0e-07 3.9e-07 1.1e-07
5 RMTg isoform ratio XM_063271617.1 0.34 0.14 7.4e-09 0.2 0.22 0.21 0.22 4.8e-06 2.0e-06 3.6e-06 2.2e-06
6 pVTA gene expression Tut1 0.05 0.03 6.8e-05 0.05 0.05 0.04 0.05 4.8e-05 1.1e-04 3.0e-04 1.2e-04
7 RMTg alternative TSS XM_063271615.1 0.32 0.14 8.9e-09 0.23 0.21 0.21 0.23 7.7e-07 3.4e-06 3.2e-06 9.2e-07
8 RMTg isoform ratio XM_063271615.1 0.35 0.14 1.4e-09 0.23 0.23 0.23 0.23 7.9e-07 7.5e-07 7.8e-07 8.1e-07
9 Brain gene expression Tut1 0.09 0.04 1.1e-10 0.12 0.11 0.11 0.11 7.8e-11 2.1e-10 2.3e-10 2.2e-10
10 NAcc gene expression Tut1 0.03 0.02 2.0e-05 0.03 0.03 0.02 0.03 7.5e-06 1.3e-05 2.2e-04 2.9e-05
11 PL gene expression Tut1 0.04 0.02 5.4e-06 0.05 0.05 0.05 0.05 5.0e-06 3.6e-06 3.1e-06 4.9e-06
12 RMTg isoform ratio XM_063271613.1 0.17 0.1 2.5e-04 0.02 0.07 0.08 0.05 9.4e-02 6.1e-03 4.6e-03 2.3e-02
13 RMTg mRNA stability Tut1 0.23 0.13 5.0e-04 0.05 0.06 0.08 0.07 1.9e-02 1.3e-02 4.1e-03 8.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.40.72.11.50.70.7-0.7-0.9-0.6-0.5-0.9-0.7-0.7-0.81.10.5
Area under the delay curve0.10.10.50.00.10.1-0.1-0.3-0.2-0.4-0.4-0.4-0.4-0.30.30.7
BMI with tail2.69.114.73.82.72.7-2.7-3.4-2.7-2.6-3.5-2.6-2.6-3.03.82.7
BMI without tail0.61.93.60.81.21.2-1.2-1.4-1.1-1.6-1.6-1.4-1.4-0.91.71.9
Body weight3.415.118.13.84.04.0-4.0-4.1-3.7-3.9-4.3-3.8-3.8-3.93.73.4
Weight adjusted by age0.71.12.81.41.11.1-1.1-1.1-1.0-0.9-1.1-0.7-0.7-0.81.70.5
Bone surface2.34.29.33.12.12.1-2.1-2.3-1.9-1.5-2.2-1.7-1.7-2.12.21.0
Bone volume1.11.96.42.51.31.3-1.3-1.5-1.1-0.8-1.4-1.0-1.0-1.31.80.3
Breakpoint value in progressive ratio session1.61.93.41.11.61.6-1.6-1.6-1.8-1.2-1.4-1.4-1.4-1.21.10.6
Number of licking bursts0.00.10.3-0.10.20.2-0.2-0.00.1-0.2-0.0-0.4-0.40.20.60.1
Context. condit. distance diff. score0.30.30.8-0.4-0.9-0.90.90.40.40.50.30.00.00.70.50.2
Locomotion velocity, session 10.10.20.9-0.4-0.3-0.30.3-0.0-0.2-0.3-0.1-0.4-0.4-0.2-0.40.9
Locomotion distance, session 10.70.82.00.50.40.4-0.4-0.9-0.9-0.9-1.0-1.2-1.2-0.71.01.4
Locomotion velocity, session 22.52.93.91.51.71.7-1.7-1.9-2.0-1.6-1.9-1.8-1.8-1.51.61.4
Locomotion distance, session 20.30.40.9-0.30.30.3-0.3-0.5-0.6-0.6-0.6-0.9-0.90.10.50.9
Locomotion velocity, session 30.60.71.90.90.40.4-0.4-0.8-0.5-0.7-0.9-0.9-0.9-0.81.41.1
Locomotion distance, session 30.10.20.60.00.30.3-0.3-0.2-0.1-0.6-0.2-0.4-0.4-0.7-0.10.8
Stereotopy head waving bouts, day 30.20.31.90.0-0.6-0.60.6-0.00.20.4-0.2-0.2-0.20.81.40.0
Stereotopy head waving duration, day 30.20.31.2-0.4-0.6-0.60.6-0.00.10.4-0.1-0.4-0.40.91.10.1
Locomotion velocity, session 70.20.22.20.2-0.2-0.20.2-0.2-0.10.2-0.2-0.4-0.40.71.5-0.1
Locomotion distance, session 70.10.10.4-0.4-0.3-0.30.30.10.2-0.2-0.1-0.2-0.20.40.50.6
Stereotopy head waving bouts, day 70.30.31.21.00.40.4-0.4-0.6-0.60.0-0.5-0.5-0.5-0.11.1-0.3
Stereotopy head waving duration, day 71.51.82.31.51.41.4-1.4-1.5-1.5-1.1-1.4-1.4-1.4-1.01.40.7
Locomotion velocity, session 80.20.21.3-1.2-0.4-0.40.40.2-0.0-0.20.1-0.4-0.40.6-0.10.7
Locomotion distance, session 80.30.41.2-0.2-0.9-0.90.90.30.40.60.2-0.0-0.00.91.10.0
Degree of sensitization distance0.20.21.50.5-0.2-0.20.2-0.20.10.1-0.3-0.1-0.10.31.20.1
Degree of sensitization stereotypy0.91.02.41.51.11.1-1.1-1.1-1.3-0.5-1.0-0.8-0.8-0.61.2-0.0
Conditioned locomotion0.50.60.80.40.90.9-0.9-0.8-0.8-0.8-0.9-0.9-0.9-0.30.60.7
Cocaine response after cond. corrected0.60.71.4-1.2-1.2-1.21.20.80.70.40.60.10.10.7-1.00.4
Cocaine response after cond. not corrected0.40.41.1-0.5-0.9-0.90.90.60.60.40.50.40.40.1-1.00.2
Cocaine response before conditioning0.50.62.51.60.90.9-0.9-0.5-0.7-0.3-0.30.40.4-1.4-0.0-0.4
Saline control response3.14.15.81.12.22.2-2.2-1.9-2.1-2.4-1.9-2.2-2.2-2.20.92.1
Bone: connectivity density1.93.04.82.21.71.7-1.7-1.9-1.6-1.5-1.9-1.5-1.5-1.81.71.4
Bone: cortical apparent density0.20.20.7-0.00.40.4-0.4-0.4-0.7-0.4-0.4-0.9-0.9-0.2-0.00.2
Bone: cortical area1.01.63.21.81.41.4-1.4-1.3-1.2-1.0-1.2-0.9-0.9-1.31.50.4
Bone: cortical porosity0.20.21.3-0.8-0.2-0.20.20.2-0.10.40.3-0.1-0.11.1-0.3-0.6
Bone: cortical porosity0.10.10.6-0.70.00.0-0.0-0.0-0.30.0-0.0-0.4-0.40.8-0.1-0.1
Bone: cortical thickness2.84.66.60.92.52.5-2.5-2.0-2.4-2.6-2.0-2.3-2.3-2.10.62.0
Bone: cortical thickness0.40.51.2-0.20.60.6-0.6-0.4-0.6-1.0-0.5-0.8-0.8-0.7-0.61.1
Bone: cortical tissue density0.30.41.10.00.60.6-0.6-0.6-0.9-0.5-0.5-1.0-1.0-0.3-0.00.3
Condit. Reinf. active minus inactive responses1.01.11.51.21.01.0-1.0-1.1-1.2-0.9-1.1-0.9-0.9-1.20.70.8
Condit. Reinf. active-inactive response ratio0.30.30.50.40.50.5-0.5-0.6-0.7-0.5-0.6-0.7-0.7-0.6-0.10.6
Condit. Reinf. active responses0.91.13.21.81.01.0-1.0-1.2-1.1-0.6-1.2-0.6-0.6-1.11.40.3
Condit. Reinf. inactive responses0.30.31.71.30.10.1-0.1-0.20.00.4-0.10.60.6-0.31.1-0.7
Incentive salience index mean1.41.73.01.71.31.3-1.3-1.4-1.3-1.1-1.4-1.1-1.1-1.71.11.0
Condit. Reinf. lever presses1.21.63.71.91.31.3-1.3-1.3-1.1-1.1-1.3-1.0-1.0-1.81.30.9
Condit. Reinf. active minus inactive responses0.20.31.30.3-0.3-0.30.30.30.20.70.40.50.50.50.3-1.1
Condit. Reinf. active-inactive response ratio0.81.03.30.7-0.7-0.70.70.40.51.40.50.90.91.31.3-1.8
Condit. Reinf. active responses0.10.10.30.50.40.4-0.4-0.2-0.4-0.2-0.2-0.3-0.3-0.40.4-0.1
Condit. Reinf. inactive responses0.50.62.1-0.20.60.6-0.6-0.2-0.5-1.1-0.3-0.7-0.7-1.4-1.01.2
Condit. Reinf. lever presses1.01.43.51.91.41.4-1.4-1.2-1.1-1.0-1.1-0.7-0.7-1.51.00.5
Condit. Reinf. lever reinforcers received0.20.30.50.70.60.6-0.6-0.5-0.7-0.4-0.4-0.5-0.5-0.50.5-0.1
Conditioned reinforcement - actives0.40.72.50.7-0.7-0.70.80.30.21.30.51.11.10.5-0.4-1.6
Conditioned reinforcement - inactives0.30.42.11.5-0.4-0.40.4-0.10.10.9-0.00.70.7-0.20.2-1.1
Conditioned locomotion2.12.74.6-0.4-2.1-2.12.11.31.32.11.31.71.71.7-0.7-1.4
Patch foraging indifference point 0 sec0.51.01.50.70.90.9-0.9-1.0-1.0-1.0-1.0-1.2-1.2-0.91.00.9
Patch foraging indifference point AUC1.01.52.51.61.41.4-1.4-1.4-1.4-0.7-1.2-0.9-0.9-0.81.4-0.4
Delay disc. indifference point, 0s delay0.20.20.5-0.5-0.7-0.70.70.40.50.20.20.30.3-0.1-0.60.4
Delay disc. indifference point, 16s delay0.20.20.70.80.30.3-0.3-0.4-0.4-0.2-0.4-0.2-0.2-0.20.80.1
Delay disc. indifference point, 2s delay0.20.20.30.3-0.5-0.50.50.30.40.50.20.60.6-0.1-0.1-0.3
Delay disc. indifference point, 24s delay0.20.20.8-0.10.30.3-0.3-0.3-0.3-0.6-0.4-0.5-0.5-0.6-0.00.9
Delay disc. indifference point, 4s delay0.60.62.0-0.20.40.4-0.4-0.6-0.4-1.0-0.8-1.0-1.0-0.80.41.4
Delay disc. indifference point, 8s delay0.30.41.7-1.3-0.7-0.70.70.60.60.20.50.10.10.7-0.40.3
Indifference point function ln k2.33.96.3-2.3-2.5-2.52.52.22.41.31.91.51.50.9-2.40.4
Indifference point function log k2.33.96.3-2.3-2.5-2.52.52.22.41.31.91.51.50.9-2.40.4
Patch foraging total patch changes 0 sec0.51.01.70.30.90.9-0.9-0.9-1.0-1.2-0.9-1.3-1.3-1.10.51.2
Patch foraging total patch changes 12 sec5.57.19.92.13.03.0-3.0-2.9-3.1-2.5-2.8-2.9-2.9-1.92.51.5
Patch foraging total patch changes 18 sec0.50.71.30.71.01.0-1.0-0.9-1.0-0.7-0.8-0.9-0.9-0.11.10.0
Patch foraging total patch changes 24 sec4.98.410.02.53.03.0-3.0-3.0-3.0-2.9-3.0-3.2-3.2-2.72.92.2
Patch foraging total patch changes 6 sec1.42.12.91.11.41.4-1.4-1.4-1.4-1.4-1.4-1.7-1.7-1.51.41.3
Patch foraging time to switch 0 sec0.30.62.41.50.60.6-0.6-0.9-0.9-0.1-0.9-0.3-0.3-0.01.3-0.1
Patch foraging water rate 0 sec0.30.72.1-1.1-0.8-0.80.81.11.10.41.00.50.50.4-1.4-0.1
Patch foraging water rate 12 sec1.22.65.8-2.4-1.7-1.71.72.02.00.71.81.21.20.4-2.20.2
Patch foraging water rate 18 sec0.50.82.5-1.3-0.7-0.70.70.91.0-0.30.60.20.2-0.6-1.61.3
Patch foraging water rate 24 sec1.21.73.1-1.7-1.5-1.51.41.51.60.91.41.01.00.8-1.8-0.2
Patch foraging water rate 6 sec1.21.84.9-2.2-1.4-1.41.41.71.70.61.50.80.80.7-1.50.3
Seeking ratio, delayed vs. immediate footshock0.10.10.40.20.30.3-0.3-0.2-0.1-0.3-0.2-0.2-0.2-0.6-0.50.4
Distance traveled before self-admin2.22.95.92.41.81.8-1.8-1.8-1.7-1.2-1.7-1.4-1.4-1.52.20.5
Distance traveled after self-admin0.30.40.70.60.70.7-0.7-0.7-0.8-0.5-0.6-0.6-0.6-0.60.60.2
Extensor digitorum longus weight6.324.729.14.35.45.4-5.4-5.2-4.9-5.2-5.3-5.2-5.2-4.83.74.3
Bone: elastic displacement0.50.62.4-1.6-0.6-0.60.60.80.60.20.80.40.41.1-1.20.0
Bone: elastic work0.91.22.9-0.11.11.1-1.1-0.9-1.1-1.5-1.0-1.2-1.2-0.50.31.7
Bone: endosteal estimation0.71.62.60.9-1.4-1.41.40.91.51.60.81.61.60.81.1-1.2
Bone: endosteal perimeter1.42.95.31.0-1.7-1.71.71.21.92.31.32.12.11.01.3-2.1
Epididymis fat weight0.51.83.70.8-1.1-1.11.11.01.71.61.11.91.90.70.6-1.7
Delta time in closed arm before/after self-admin1.61.44.5-0.50.80.8-0.8-1.0-1.1-1.6-1.2-1.5-1.5-0.61.02.1
Delta time in open arm before/after self-admin1.81.84.82.21.41.4-1.4-1.5-1.6-0.7-1.4-1.0-1.0-1.01.5-0.1
Diff in mean of infusions in LGA sessions2.02.43.80.81.61.6-1.6-1.7-1.8-1.6-1.6-2.0-2.0-1.60.81.3
Delay discount exponential model param0.10.10.5-0.0-0.1-0.10.10.30.30.40.40.50.50.4-0.3-0.7
Extinction: sum of active levers before priming3.74.14.82.12.12.1-2.1-2.2-2.1-1.8-2.1-2.1-2.1-2.01.91.5
Active lever presses in extinction session 62.52.54.82.21.71.7-1.7-1.8-1.9-1.1-1.6-1.3-1.3-1.61.40.4
Bone: final force1.82.95.12.31.81.8-1.8-1.8-1.6-1.5-1.8-1.4-1.4-1.82.01.1
Bone: final moment1.93.05.02.21.81.8-1.8-1.8-1.6-1.5-1.8-1.5-1.5-1.82.01.2
Food consumed during 24 hour testing period0.10.10.40.10.00.0-0.00.40.40.20.50.50.50.1-0.6-0.5
Glucose1.72.74.8-1.0-1.9-1.91.91.72.21.71.61.81.81.3-0.5-1.0
Heart weight0.10.20.9-0.3-0.5-0.50.50.30.8-0.10.10.30.3-0.20.30.9
Delay discount hyperbolic model param0.10.10.3-0.1-0.0-0.00.00.20.20.30.30.30.30.3-0.2-0.5
Intermittent access intake day 1-15 change1.22.65.3-0.5-1.4-1.41.41.51.31.91.61.91.91.2-1.6-2.3
Intermittent access intake escalation1.53.26.5-0.5-1.6-1.61.61.61.52.11.82.12.11.4-1.7-2.6
Intermittent access intake escalation 20.91.03.40.2-0.7-0.70.80.70.51.30.91.31.30.7-0.8-1.9
Intermitt. access day 1 inactive lever presses0.41.62.9-0.9-1.3-1.31.31.20.91.61.31.41.41.2-0.7-1.7
Intermitt. access day 15 inactive lever presses0.61.15.52.30.80.8-0.8-1.2-1.1-0.3-1.0-0.2-0.2-1.51.2-0.3
Intermitt. access escalation Index0.60.82.2-1.3-0.9-0.90.91.00.90.61.00.70.70.5-1.5-0.2
Intermittent access day 1 total infusions0.40.61.81.4-0.9-0.90.90.00.30.9-0.10.90.90.40.7-0.4
Intermittent access day 15 total infusions3.04.47.50.2-2.3-2.32.31.71.82.71.82.72.71.6-1.2-2.5
Intermittent access terminal intake (last 3 days)1.21.63.21.5-1.3-1.31.30.50.71.80.61.71.70.90.0-1.8
Intermittent access total infusions1.21.42.81.1-1.4-1.41.40.50.71.70.51.51.51.00.2-1.3
Intermittent access day 1 locomotion0.20.31.31.1-0.5-0.50.5-0.3-0.10.5-0.40.30.30.31.0-0.0
Intermittent access day 15 total locomotion0.40.72.81.7-0.7-0.70.7-0.10.01.2-0.00.90.90.40.6-1.2
Intermittent access total locomotion0.91.16.02.5-0.8-0.80.8-0.30.01.3-0.31.01.00.41.0-1.2
Intermittent access standard deviation0.61.32.3-0.2-1.2-1.21.21.00.81.51.01.51.51.1-0.4-1.5
Left kidney weight0.10.40.70.8-0.5-0.50.50.20.70.80.20.80.80.30.8-0.7
Right kidney weight0.00.20.40.6-0.2-0.20.20.20.60.60.20.60.60.20.6-0.6
Cocaine induced anxiety0.00.00.30.30.10.1-0.1-0.2-0.30.1-0.10.10.1-0.00.1-0.5
Post-drug Anxiety0.30.31.00.70.60.6-0.6-0.6-0.6-0.4-0.5-0.4-0.4-1.0-0.10.1
Baseline Anxiety0.50.61.60.10.60.6-0.6-0.6-0.5-0.9-0.7-0.9-0.9-1.0-0.11.3
Tail length0.31.42.5-0.41.41.4-1.4-0.8-0.9-1.6-0.8-1.5-1.5-0.8-0.01.3
Length with tail1.46.18.21.42.92.9-2.9-2.3-2.3-2.8-2.3-2.8-2.8-2.71.02.2
Length without tail3.09.513.72.13.33.3-3.3-3.0-2.9-3.3-3.1-3.5-3.5-3.71.52.8
Times rat made contact with spout0.30.30.7-0.70.40.4-0.4-0.1-0.4-0.8-0.2-0.7-0.7-0.2-0.70.8
Lifetime Intake0.81.01.90.7-1.3-1.31.30.50.61.40.41.31.30.90.1-0.8
Liver weight, left1.01.72.2-1.4-1.3-1.31.31.51.51.11.41.31.31.2-1.3-1.0
Liver weight, right1.01.73.0-1.3-1.5-1.51.51.61.70.91.41.21.20.6-1.4-0.2
Locomotor activity0.91.45.3-2.3-1.1-1.11.11.31.10.21.10.60.60.5-1.80.6
Locomotor testing distance0.81.54.7-2.2-1.2-1.21.21.31.20.11.10.70.70.4-2.00.8
Locomotor testing rearing0.71.43.6-1.8-1.2-1.21.21.41.30.41.31.01.00.3-1.90.3
Locomotion in novel chamber1.82.33.5-0.4-1.7-1.71.71.41.41.91.41.91.91.7-0.5-1.6
Locomotion in novel chamber post-restriction1.83.05.7-1.2-1.9-1.91.91.61.52.11.71.61.62.4-0.5-2.0
Fecal boli incidents, locomotor time 10.40.52.30.6-0.4-0.40.40.40.41.00.50.90.90.7-0.1-1.5
Change in fecal boli incidents, locomotor task1.01.02.5-1.6-1.2-1.21.21.11.20.50.90.50.50.5-1.30.2
Time >=10cm from walls, locomotor time 12.02.24.80.5-1.4-1.41.41.11.32.11.31.71.71.4-0.2-2.2
Bouts of movement, locomotor time 10.10.20.5-0.50.30.3-0.3-0.1-0.70.10.1-0.2-0.20.5-0.6-0.6
Total resting periods, locomotor time 10.10.10.5-0.20.30.3-0.3-0.2-0.60.10.0-0.1-0.10.3-0.4-0.7
Rest time, locomotor task time 11.62.02.6-1.2-1.3-1.31.31.61.51.41.61.51.51.5-1.0-1.5
Distance moved, locomotor task time 10.30.40.90.80.60.6-0.6-0.7-0.6-0.6-0.8-0.5-0.5-0.90.30.7
Vertical activity count, locomotor time 10.20.50.8-0.6-0.8-0.80.80.70.80.60.60.60.60.4-0.9-0.3
Time >=10cm from walls, locomotor time 20.20.31.60.6-0.1-0.10.10.20.10.80.40.60.60.3-0.1-1.3
Bouts of movement, locomotor time 20.71.21.80.91.31.3-1.3-1.1-1.3-1.1-1.1-1.0-1.0-0.90.80.8
Total resting periods, locomotor time 20.30.50.80.70.90.9-0.9-0.7-0.9-0.7-0.7-0.6-0.6-0.50.70.4
Rest time, locomotor task time 22.83.54.5-1.8-2.0-2.02.02.02.01.91.91.71.72.1-1.3-1.5
Distance moved, locomotor task time 20.40.40.90.40.80.8-0.8-0.7-1.0-0.8-0.6-0.5-0.5-0.80.00.5
Vertical activity count, locomotor time 20.10.21.2-1.1-0.1-0.10.10.30.1-0.30.3-0.1-0.1-0.0-0.90.4
Light reinforcement 10.10.10.6-0.2-0.0-0.00.00.40.2-0.00.40.30.3-0.7-0.8-0.2
Light reinforcement 20.40.62.71.4-0.1-0.10.10.10.31.00.31.01.0-0.00.6-1.7
Bone: marrow area0.91.93.00.7-1.5-1.51.51.01.71.71.01.71.71.01.0-1.2
Bone: maximum diameter0.30.63.01.70.50.5-0.5-0.7-0.40.1-0.6-0.1-0.1-0.51.7-0.5
Bone: maximum force2.95.111.43.42.32.3-2.3-2.4-2.0-1.7-2.4-1.6-1.6-2.23.11.2
Bone: maximum moment2.95.110.73.32.32.3-2.3-2.4-2.0-1.8-2.4-1.6-1.6-2.13.01.3
Mean time between licks in bursts0.40.94.2-0.50.60.6-0.6-0.4-0.4-1.6-0.6-0.8-0.8-1.2-0.82.1
Mean num. licks in bursts0.10.21.3-0.7-0.3-0.30.30.3-0.0-0.00.30.20.20.1-1.20.2
Cd content in liver0.91.02.3-0.2-1.1-1.11.10.80.81.40.90.80.81.5-0.1-1.4
Co content in liver1.21.44.7-2.1-1.1-1.11.11.30.90.51.20.50.50.7-2.2-0.0
Cu content in liver0.00.10.3-0.6-0.2-0.20.20.20.00.10.2-0.0-0.00.3-0.50.1
Fe content in liver0.00.00.1-0.2-0.3-0.30.30.10.10.30.0-0.0-0.00.20.1-0.0
K content in liver0.80.71.80.90.90.9-0.9-0.7-0.6-0.9-0.7-0.6-0.6-1.31.10.8
Mg content in liver0.20.20.70.20.10.1-0.1-0.2-0.1-0.5-0.3-0.5-0.5-0.80.70.9
Mn content in liver3.23.64.52.02.12.1-2.1-2.0-1.9-1.7-1.9-1.8-1.8-2.01.91.0
Na content in liver0.60.71.81.20.80.8-0.8-0.7-0.7-0.7-0.7-0.5-0.5-1.31.10.4
Rb content in liver2.12.44.1-2.0-1.7-1.71.71.91.81.21.71.41.41.1-1.5-0.6
Se content in liver0.20.31.81.00.40.4-0.4-0.4-0.30.1-0.30.00.00.11.3-0.5
Sr content in liver3.83.34.61.42.02.0-2.0-2.0-2.2-1.8-2.0-2.1-2.1-1.41.21.1
Zn content in liver2.62.94.31.31.61.6-1.6-1.9-1.9-1.6-1.9-2.1-2.1-1.11.71.4
Bone: minimum diameter0.50.91.61.3-0.7-0.70.70.51.01.10.51.21.20.41.3-1.0
Time in familiar zone, hab. session 10.10.10.60.80.20.2-0.2-0.3-0.3-0.3-0.3-0.1-0.1-0.70.00.4
Time in novel zone, hab. session 11.41.42.3-1.5-1.2-1.21.21.31.30.81.31.01.00.8-1.4-0.5
Total zone transitions, hab. session 10.20.31.00.10.50.5-0.5-0.5-0.6-0.4-0.5-1.0-1.0-0.40.40.4
Total locomotion distance, hab. session 10.10.21.20.4-0.4-0.40.4-0.00.10.6-0.0-0.1-0.10.31.1-0.5
Locomotion velocity, hab. session 10.20.31.80.60.30.3-0.2-0.6-0.50.0-0.6-0.7-0.70.01.3-0.1
Time in familiar zone, hab. session 20.70.85.9-0.9-0.3-0.30.30.80.7-0.10.80.70.7-0.5-2.40.3
Time in novel zone, hab. session 20.70.73.70.90.60.6-0.6-0.9-0.8-0.4-1.0-0.8-0.8-0.21.90.4
Total zone transitions, hab. session 21.52.03.11.21.21.2-1.2-1.4-1.3-1.5-1.4-1.6-1.6-1.80.81.7
Total locomotion distance, hab. session 20.20.30.60.60.30.3-0.3-0.5-0.4-0.4-0.6-0.7-0.7-0.80.80.7
Locomotion velocity, hab. session 20.20.21.00.70.10.1-0.1-0.4-0.2-0.1-0.5-0.5-0.5-0.51.00.3
Novel to familiar place preference ratio1.82.03.31.41.61.6-1.6-1.7-1.4-1.1-1.6-1.2-1.2-1.01.80.5
Novelty place preference1.11.22.41.21.31.3-1.3-1.3-1.0-0.8-1.2-0.9-0.9-0.71.50.3
Time in novel zone, NPP test1.21.32.41.11.31.3-1.3-1.3-1.1-0.9-1.3-0.9-0.9-0.71.60.4
Total zone transitions, NPP test1.11.62.90.71.11.1-1.1-1.3-1.4-1.3-1.4-1.7-1.7-0.71.11.4
Total locomotion distance, NPP test0.10.20.5-0.0-0.0-0.0-0.0-0.4-0.4-0.2-0.5-0.7-0.70.20.70.6
Locomotion velocity, NPP test0.10.10.4-0.2-0.1-0.10.1-0.2-0.3-0.0-0.3-0.6-0.60.40.60.3
Intraocular pressure0.20.30.9-0.6-0.3-0.30.30.50.40.50.60.50.50.6-1.0-0.6
Delta distance traveled before/after self-admin0.70.83.0-1.7-0.8-0.80.80.90.80.30.80.30.30.1-1.70.3
Delta ambulatory time before/after self-admin0.91.23.8-2.0-1.0-1.01.01.11.00.51.00.50.50.5-1.90.1
Parametrial fat weight1.22.84.80.3-1.7-1.71.71.41.82.21.42.12.11.50.5-2.1
Pavlov. Cond. lever latency1.11.43.0-1.7-1.2-1.21.21.21.11.01.20.90.91.3-1.2-0.7
Pavlov. Cond. magazine entry latency1.21.65.92.41.31.3-1.3-1.3-1.2-0.7-1.2-0.5-0.5-1.31.50.1
Pavlov. Cond. change in total contacts0.60.63.31.80.70.7-0.7-0.8-0.70.0-0.6-0.2-0.2-0.51.1-0.6
Pavlov. Cond. index score0.80.93.11.81.11.1-1.1-1.0-1.0-0.6-0.9-0.5-0.5-1.00.90.1
Pavlov. Cond. latency score0.70.92.81.71.01.0-1.0-1.0-0.9-0.7-0.9-0.5-0.5-1.10.80.3
Pavlov. Cond. lever contacts0.60.72.21.50.80.8-0.8-0.9-0.7-0.7-0.8-0.5-0.5-1.10.90.5
Pavlov. Cond. magazine entry number0.70.92.9-1.7-1.1-1.11.11.11.10.60.90.50.50.9-0.80.1
Pavlov. Cond. intertrial magazine entries0.10.10.60.00.10.1-0.1-0.1-0.30.3-0.00.30.30.60.2-0.7
Pavlov. Cond. lever-magazine prob. diff.0.81.03.51.91.11.1-1.1-1.1-1.0-0.6-1.0-0.5-0.5-0.91.1-0.0
Pavlov. Cond. response bias1.01.23.92.01.31.2-1.2-1.2-1.2-0.7-1.1-0.6-0.6-1.11.10.1
Pavlov. Cond. lever latency0.60.82.5-1.6-1.0-1.01.00.90.80.70.80.40.41.3-0.5-0.4
Pavlov. Cond. magazine entry latency4.65.68.02.82.72.7-2.6-2.6-2.8-2.2-2.5-1.9-1.9-2.61.41.4
Pavlov. Cond. change in total contacts1.32.16.92.61.61.6-1.6-1.5-1.5-0.9-1.3-0.7-0.7-1.91.10.1
Pavlov. Cond. index score2.63.58.22.92.12.1-2.1-2.0-2.1-1.5-1.9-1.1-1.1-2.21.30.7
Pavlov. Cond. latency score2.43.28.02.82.02.0-2.0-2.0-2.0-1.3-1.8-1.1-1.1-2.01.40.6
Pavlov. Cond. lever contacts0.50.72.31.50.90.9-0.9-0.8-0.8-0.6-0.7-0.2-0.2-1.20.20.2
Pavlov. Cond. magazine entry number6.98.512.0-3.5-3.3-3.33.33.23.42.63.12.42.43.0-2.0-1.6
Pavlov. Cond. intertrial magazine entries1.52.23.4-1.4-1.6-1.61.61.61.51.71.61.21.21.8-0.6-1.6
Pavlov. Cond. lever-magazine prob. diff.2.93.98.83.02.22.2-2.2-2.2-2.2-1.6-2.0-1.2-1.2-2.31.30.8
Pavlov. Cond. response bias2.02.75.32.31.91.9-1.9-1.7-1.7-1.5-1.6-1.1-1.1-2.20.81.0
Time in closed arm before self-admin0.20.20.80.90.00.0-0.00.10.10.50.20.60.6-0.1-0.0-0.8
Time in closed arm after self-admin0.60.71.3-1.1-0.8-0.80.81.00.90.50.90.90.90.6-1.0-0.2
Time in open arm before self-admin1.31.46.8-2.6-1.2-1.21.21.21.30.10.90.10.11.0-1.21.1
Time in open arm after self-admin0.40.51.1-0.00.40.4-0.4-0.6-0.6-0.6-0.7-1.1-1.10.21.10.9
Bone: periosteal estimation0.30.63.51.90.10.1-0.1-0.30.20.4-0.30.40.4-0.31.9-0.6
Bone: periosteal perimeter0.20.42.41.60.20.2-0.2-0.20.10.4-0.20.30.3-0.61.3-0.7
Bone: post-yield work0.71.16.02.5-0.2-0.20.2-0.40.20.8-0.30.70.7-0.02.2-0.9
Progressive ratio test 1 active lever presses0.40.61.20.2-1.0-1.01.00.40.31.10.40.80.81.00.2-0.7
Progressive ratio test 1 breakpoint0.50.61.20.2-1.0-1.01.00.40.31.10.40.80.80.90.2-0.8
Progressive ratio test 1 inactive lever presses0.50.81.51.20.70.7-0.7-1.1-1.1-0.6-1.1-0.6-0.6-0.81.10.5
Progressive ratio test 2 active lever presses1.11.32.80.8-1.3-1.31.30.60.51.70.71.41.40.90.1-1.6
Progressive ratio test 2 breakpoint1.01.22.60.9-1.2-1.21.20.50.51.60.61.41.40.90.1-1.5
Progressive ratio test 2 inactive lever presses0.60.92.31.1-0.9-0.90.90.30.41.40.41.31.30.40.1-1.5
Incentive Sensitization - Responses0.70.94.52.10.70.7-0.7-1.1-1.0-0.3-1.0-0.3-0.3-1.01.2-0.1
Incentive Sensitization - Breakpoint0.60.84.32.10.60.6-0.6-1.0-0.8-0.2-0.9-0.2-0.2-0.91.0-0.2
Sum of active levers in priming session hrs 5-60.80.71.91.41.01.0-0.9-0.9-1.1-0.0-0.6-0.3-0.3-0.60.6-1.1
Progressive ratio0.10.11.31.10.10.1-0.1-0.20.00.2-0.20.30.3-0.00.4-0.3
Food seeking constrained by brief footshock0.10.10.9-0.3-0.2-0.20.20.20.10.00.20.00.0-0.4-1.00.2
Seeking ratio, punishment vs. effort0.20.31.8-1.4-0.2-0.20.20.20.1-0.40.1-0.4-0.4-0.3-0.80.8
Retroperitoneal fat weight3.012.817.1-2.4-4.0-4.04.03.74.13.83.64.04.03.4-1.9-2.8
Reaction time number correct0.40.82.60.21.01.0-1.0-0.5-0.4-1.3-0.6-0.7-0.7-1.60.11.2
Reaction time mean minus median0.20.51.31.10.80.8-0.8-0.7-0.90.1-0.5-0.2-0.20.10.4-1.1
Reaction time mean minus median AUC0.10.10.80.10.40.4-0.4-0.2-0.40.1-0.00.00.00.2-0.4-0.9
Reaction time num false alarms0.50.73.4-1.9-0.8-0.80.80.70.60.00.50.00.00.6-1.10.8
Reaction time num false alarms AUC0.30.53.1-1.8-0.3-0.30.30.20.1-0.50.1-0.6-0.60.3-0.91.2
Reaction time trials correct on left0.40.82.60.21.01.0-1.0-0.5-0.4-1.3-0.6-0.7-0.7-1.60.11.2
Reaction time trials on left0.50.92.60.21.11.1-1.1-0.6-0.5-1.3-0.6-0.7-0.7-1.60.11.2
Reaction time mean0.20.31.50.5-0.3-0.30.30.1-0.10.90.30.60.60.5-0.6-1.2
Reaction time mean AUC0.30.41.70.5-0.3-0.30.30.30.11.00.50.80.80.3-0.6-1.3
Median of all reaction times0.10.20.70.6-0.3-0.30.30.0-0.10.80.20.40.40.3-0.4-0.8
Reaction time omissions0.20.20.60.20.60.6-0.6-0.5-0.8-0.3-0.4-0.5-0.5-0.2-0.6-0.2
Reaction time false alarm rate0.40.62.4-1.5-0.9-0.90.90.50.40.30.4-0.0-0.01.1-0.90.4
Reaction time premature initiation rate4.96.810.41.82.62.6-2.6-2.4-2.3-3.2-2.6-2.7-2.7-3.11.53.2
Reaction time premature initiations4.78.413.91.53.13.1-3.1-2.6-2.5-3.7-2.7-2.9-2.9-3.61.43.5
Std. dev. reaction times0.20.42.3-0.0-0.3-0.30.30.2-0.11.00.40.50.51.0-0.6-1.5
Reaction time trials completed0.50.92.60.21.11.1-1.1-0.6-0.5-1.3-0.6-0.7-0.7-1.60.11.2
Reaction time trials AUC0.40.72.50.20.90.9-0.9-0.5-0.4-1.2-0.5-0.6-0.6-1.60.01.2
Run reversals in cocaine runway, females0.70.73.30.30.50.5-0.5-0.7-0.4-1.0-0.9-1.1-1.1-0.70.11.8
Run reversals in cocaine runway, males0.50.51.1-1.1-0.7-0.70.70.80.70.60.80.30.30.7-0.6-0.5
Latency to leave start box in cocaine runway0.30.30.60.2-0.6-0.60.60.40.70.60.40.80.80.0-0.3-0.4
Latency to leave start box in cocaine runway, F0.10.10.70.40.20.2-0.2-0.3-0.2-0.3-0.3-0.1-0.1-0.8-0.00.2
Latency to leave start box in cocaine runway, M1.91.82.5-0.7-1.5-1.51.51.31.61.41.31.51.51.3-0.7-1.0
Std. dev. time between licks in bursts0.40.53.1-1.0-0.2-0.20.20.40.4-0.60.30.10.1-0.7-1.81.1
Total sessions with >9 infusions0.70.91.4-0.3-1.2-1.21.20.80.71.10.71.11.11.0-0.4-0.6
Short access day 1 total inactive lever presses0.10.10.30.4-0.5-0.50.5-0.10.20.4-0.20.10.10.50.30.2
Short access day 10 total inactive lever presses0.30.71.1-1.1-0.9-0.90.90.91.00.80.90.70.71.0-0.5-0.5
Short access day 1 total infusions1.01.42.1-0.5-1.5-1.51.51.11.11.31.01.31.31.3-0.8-0.7
Short access day 10 total infusions0.30.41.01.0-0.7-0.70.70.10.30.8-0.00.70.70.30.5-0.2
Short access total infusions0.40.61.20.0-1.1-1.11.10.50.60.90.40.80.80.8-0.0-0.1
Short access day 1 locomotion0.30.40.90.3-0.8-0.80.80.30.40.80.30.70.71.00.2-0.5
Short access day 10 total locomotion0.20.32.31.5-0.1-0.10.1-0.5-0.30.3-0.5-0.0-0.0-0.30.9-0.1
Short access total locomotion0.20.30.91.0-0.6-0.60.6-0.10.10.8-0.10.50.50.50.6-0.4
One hour access (0.3 mA shock)1.11.22.50.6-1.3-1.31.30.70.91.60.71.41.40.9-0.2-1.3
Compulsive drug intake0.91.12.4-0.81.21.2-1.2-0.5-0.6-1.5-0.6-1.3-1.3-0.60.21.5
One hour access (shock baseline)2.64.07.40.4-2.3-2.32.31.51.62.71.62.52.51.7-0.7-2.5
Social response proportion0.10.20.6-0.00.50.5-0.5-0.1-0.3-0.6-0.10.00.0-0.8-0.60.4
Social responses0.10.20.6-0.70.40.4-0.40.1-0.3-0.60.1-0.2-0.2-0.3-0.80.4
Social time0.10.21.4-1.20.00.0-0.00.3-0.1-0.20.3-0.3-0.30.1-0.70.2
Soleus weight2.77.910.0-2.5-3.2-3.23.23.13.02.83.02.82.82.7-2.0-2.0
Bone: stiffness0.81.34.52.11.21.2-1.2-1.1-0.9-0.5-1.0-0.5-0.5-1.21.6-0.1
Tibialis anterior weight8.328.034.64.25.95.9-5.9-5.7-5.7-5.2-5.7-5.8-5.8-4.24.23.8
Time to tail flick, vehicle, before self-admin0.30.31.31.10.30.3-0.3-0.6-0.4-0.1-0.6-0.2-0.2-0.11.20.1
Time to tail flick, vehicle, after self-admin0.30.50.90.60.50.5-0.5-0.7-0.6-0.7-0.8-0.7-0.7-0.90.61.0
Time to tail flick, test, before self-admin0.60.62.00.70.30.3-0.3-0.7-0.2-0.7-0.9-0.9-0.9-0.21.41.3
Time to tail flick, test, after self-admin0.10.10.30.60.30.3-0.3-0.1-0.10.1-0.10.10.10.40.4-0.4
Delta time to tail flick, vehicle, before/after SA0.30.30.7-0.00.50.5-0.5-0.4-0.5-0.7-0.5-0.7-0.7-0.6-0.10.8
Delta time to tail flick, test, before/after SA0.20.21.5-0.10.20.2-0.20.2-0.20.40.40.50.50.4-0.4-1.2
Tibia length1.54.08.72.92.12.1-2.1-2.2-2.1-1.0-2.0-1.7-1.7-1.62.8-0.1
Ambulatory time before self-admin1.62.36.12.51.61.6-1.6-1.7-1.6-0.9-1.5-1.1-1.1-1.51.90.2
Ambulatory time after self-admin0.20.20.80.90.40.4-0.4-0.4-0.6-0.1-0.4-0.2-0.2-0.80.3-0.2
Bone: tissue strength0.30.30.7-0.6-0.3-0.30.30.70.80.00.70.60.6-0.2-0.70.0
Total heroin consumption4.85.67.41.52.72.7-2.7-2.5-2.7-2.4-2.4-2.7-2.7-1.81.91.5
Bone: trabecular number1.22.04.02.01.31.3-1.3-1.5-1.2-1.1-1.5-1.2-1.2-1.41.71.0
Bone: trabecular spacing0.71.03.7-1.6-0.8-0.80.81.10.80.31.10.80.80.4-1.9-0.1
Bone: trabecular thickness0.20.30.80.5-0.4-0.40.40.30.50.80.40.60.60.40.1-0.9
Bone: trabecular tissue density5.27.69.2-2.9-3.0-3.03.02.92.72.83.02.52.52.7-2.4-2.3
Water consumed over 24 hours0.60.81.60.21.11.1-1.1-0.6-0.7-1.3-0.7-1.0-1.0-1.1-0.31.1
Number of responses in last shaping day0.20.20.7-0.40.30.3-0.3-0.4-0.7-0.5-0.5-0.6-0.60.20.40.8