Hub : Genes

Ehd1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 LHb gene expression Ehd1 0.13 0.08 7.4e-03 0.11 0.06 0.11 0.08 1.2e-03 1.2e-02 1.8e-03 6.3e-03
2 NAcc gene expression Ehd1 0.09 0.04 0.0e+00 0.13 0.13 0.13 0.14 1.0e-19 5.0e-19 1.0e-19 5.1e-20
3 pVTA gene expression Ehd1 0.14 0.07 3.6e-14 0.17 0.17 0.18 0.18 1.5e-13 6.0e-14 2.5e-14 2.5e-14
4 Eye gene expression Ehd1 0.35 0.15 9.8e-04 0.02 0.06 0.04 0.03 1.4e-01 4.5e-02 7.8e-02 1.3e-01
5 Liver gene expression Ehd1 0.22 0.09 0.0e+00 0.13 0.16 0.14 0.15 2.2e-14 5.9e-17 3.1e-15 1.4e-16
6 PL gene expression Ehd1 0.07 0.04 4.3e-10 0.08 0.09 0.09 0.09 1.7e-09 1.0e-09 1.4e-09 8.7e-10
7 Brain gene expression Ehd1 0.14 0.06 9.4e-16 0.16 0.14 0.14 0.15 6.9e-15 7.1e-13 6.0e-13 4.5e-14
8 IL gene expression Ehd1 0.2 0.12 6.2e-03 0.06 0.04 0.06 0 1.3e-02 3.2e-02 1.3e-02 3.1e-01
9 Adipose gene expression Ehd1 0.07 0.04 4.3e-06 0.03 0.03 0.03 0.03 2.9e-04 1.1e-04 3.7e-04 6.8e-04
10 IC gene expression Ehd1 0.21 0.1 9.2e-08 0.11 0.15 0.15 0.15 1.7e-05 5.5e-07 7.4e-07 9.0e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bone: apparent density0.30.41.0-0.7-0.9-0.8-0.3-1.0-0.2-0.61.00.3-0.0
Area under the delay curve0.00.00.30.10.0-0.10.1-0.2-0.2-0.20.60.20.1
BMI with tail1.03.37.2-2.4-2.4-2.4-1.0-2.7-0.8-2.11.70.3-0.5
BMI without tail0.61.83.4-1.7-1.6-1.7-1.0-1.8-1.1-1.70.3-0.4-0.9
Body weight2.29.616.0-3.8-3.7-3.8-2.9-4.0-2.7-3.6-0.1-1.9-2.5
Weight adjusted by age1.32.02.3-1.5-1.5-1.5-1.5-1.4-1.4-1.3-1.3-1.3-1.2
Bone surface2.64.88.7-2.9-3.0-2.7-2.1-3.0-1.5-2.20.3-1.1-1.3
Bone volume0.71.32.8-1.6-1.7-1.4-0.8-1.6-0.4-0.91.00.0-0.1
Breakpoint value in progressive ratio session2.42.84.0-1.8-2.0-2.0-1.8-2.0-1.5-1.6-1.0-1.4-1.3
Number of licking bursts0.10.20.5-0.7-0.6-0.5-0.5-0.5-0.4-0.4-0.3-0.3-0.2
Context. condit. distance diff. score1.51.82.91.71.61.41.51.31.11.31.01.21.1
Locomotion velocity, session 10.10.20.5-0.0-0.2-0.3-0.3-0.3-0.6-0.50.1-0.5-0.7
Locomotion distance, session 10.40.51.0-0.7-0.8-0.8-0.4-0.9-0.6-1.00.7-0.1-0.5
Locomotion velocity, session 22.22.63.9-1.9-1.9-1.9-1.5-2.0-1.5-1.8-0.5-1.1-1.3
Locomotion distance, session 20.60.81.6-1.0-1.0-1.0-0.8-1.0-0.9-1.30.1-0.5-0.8
Locomotion velocity, session 30.70.83.90.50.40.50.90.20.70.22.01.10.6
Locomotion distance, session 30.00.00.20.20.20.10.20.10.10.00.40.20.0
Stereotopy head waving bouts, day 31.01.14.20.80.80.81.20.51.00.42.01.30.8
Stereotopy head waving duration, day 30.91.12.00.90.91.01.10.81.10.71.41.21.0
Locomotion velocity, session 71.01.13.10.60.60.71.10.61.10.61.81.41.2
Locomotion distance, session 70.10.10.50.10.10.10.3-0.00.1-0.30.70.30.0
Stereotopy head waving bouts, day 70.30.40.90.10.20.30.50.20.70.60.90.80.9
Stereotopy head waving duration, day 70.30.30.9-0.9-0.9-0.8-0.5-0.7-0.3-0.40.1-0.00.1
Locomotion velocity, session 81.41.72.7-1.0-1.1-1.3-1.3-1.4-1.5-1.4-0.6-1.3-1.6
Locomotion distance, session 80.40.62.40.60.50.50.90.30.70.41.51.00.7
Degree of sensitization distance0.10.10.8-0.0-0.00.00.3-0.10.3-0.20.90.50.1
Degree of sensitization stereotypy0.10.20.5-0.7-0.6-0.5-0.2-0.4-0.0-0.10.30.10.3
Conditioned locomotion1.61.82.5-1.5-1.4-1.4-1.4-1.5-1.2-1.6-0.7-1.2-1.3
Cocaine response after cond. corrected0.91.12.21.51.31.21.11.10.90.70.90.80.6
Cocaine response after cond. not corrected0.70.81.61.31.11.01.00.80.80.60.80.80.5
Cocaine response before conditioning0.40.51.0-1.0-0.9-0.9-0.8-0.8-0.6-0.4-0.7-0.5-0.4
Saline control response4.76.27.2-2.6-2.6-2.7-2.5-2.7-2.5-2.7-1.9-2.3-2.5
Bone: connectivity density1.42.34.4-1.8-1.9-1.9-1.4-2.1-1.2-1.60.2-0.7-1.0
Bone: cortical apparent density0.20.31.4-0.3-0.3-0.3-0.6-0.1-0.6-0.3-1.2-0.8-0.4
Bone: cortical area0.40.61.1-1.0-1.0-0.9-0.8-1.1-0.6-0.7-0.2-0.5-0.6
Bone: cortical porosity0.10.10.2-0.5-0.5-0.4-0.3-0.4-0.3-0.4-0.4-0.2-0.2
Bone: cortical porosity0.50.60.8-0.9-0.9-0.8-0.7-0.9-0.7-0.8-0.6-0.5-0.6
Bone: cortical thickness3.76.27.6-2.1-2.3-2.4-2.7-2.3-2.6-2.4-2.6-2.7-2.6
Bone: cortical thickness1.21.42.6-0.6-0.8-1.0-1.2-0.9-1.5-1.2-1.1-1.5-1.6
Bone: cortical tissue density0.40.61.9-0.5-0.5-0.5-0.8-0.2-0.8-0.5-1.4-1.0-0.6
Condit. Reinf. active minus inactive responses0.10.20.2-0.4-0.4-0.4-0.4-0.4-0.5-0.5-0.4-0.3-0.3
Condit. Reinf. active-inactive response ratio0.10.10.6-0.1-0.1-0.2-0.3-0.1-0.4-0.2-0.8-0.4-0.2
Condit. Reinf. active responses0.00.00.1-0.1-0.0-0.00.2-0.10.2-0.00.30.40.3
Condit. Reinf. inactive responses0.50.61.80.30.40.50.80.20.90.51.31.10.9
Incentive salience index mean0.20.20.4-0.6-0.5-0.6-0.3-0.7-0.3-0.6-0.0-0.1-0.2
Condit. Reinf. lever presses0.20.30.7-0.8-0.7-0.6-0.3-0.8-0.0-0.40.50.2-0.0
Condit. Reinf. active minus inactive responses0.30.40.70.20.30.40.50.40.70.70.80.70.8
Condit. Reinf. active-inactive response ratio1.92.13.80.91.01.21.41.01.81.52.01.71.7
Condit. Reinf. active responses0.00.00.1-0.4-0.3-0.2-0.1-0.10.00.00.10.10.2
Condit. Reinf. inactive responses0.81.01.4-0.9-0.9-1.0-1.0-0.8-1.2-1.0-1.1-1.0-0.9
Condit. Reinf. lever presses0.91.32.9-1.7-1.6-1.4-1.1-1.4-0.7-1.00.1-0.6-0.6
Condit. Reinf. lever reinforcers received0.10.20.5-0.7-0.7-0.5-0.5-0.4-0.3-0.2-0.1-0.3-0.0
Conditioned reinforcement - actives0.10.20.5-0.00.10.20.30.30.70.60.70.50.7
Conditioned reinforcement - inactives3.55.26.82.32.22.32.22.32.52.61.72.12.4
Conditioned locomotion8.310.714.03.43.43.63.33.73.33.52.22.83.2
Patch foraging indifference point 0 sec0.00.00.10.20.20.10.20.20.20.30.00.20.3
Patch foraging indifference point AUC1.82.63.9-1.8-2.0-2.0-1.8-1.7-1.4-1.2-1.4-1.5-1.2
Delay disc. indifference point, 0s delay0.30.31.80.60.30.10.5-0.00.20.11.30.60.3
Delay disc. indifference point, 16s delay0.91.01.40.91.01.01.01.01.00.90.81.11.2
Delay disc. indifference point, 2s delay0.30.31.10.40.30.30.50.10.50.41.10.70.5
Delay disc. indifference point, 24s delay0.10.10.40.10.1-0.1-0.20.0-0.4-0.2-0.6-0.4-0.4
Delay disc. indifference point, 4s delay0.00.00.10.30.2-0.10.1-0.2-0.3-0.30.20.1-0.2
Delay disc. indifference point, 8s delay0.10.10.20.0-0.1-0.1-0.1-0.2-0.4-0.40.3-0.1-0.3
Indifference point function ln k5.08.813.33.53.63.43.23.22.72.52.22.62.2
Indifference point function log k5.08.813.33.53.63.43.23.22.72.52.22.62.2
Patch foraging total patch changes 0 sec0.00.00.30.10.0-0.0-0.10.0-0.2-0.0-0.5-0.2-0.2
Patch foraging total patch changes 12 sec4.25.47.4-2.7-2.7-2.7-2.4-2.5-2.2-2.3-1.7-2.0-1.9
Patch foraging total patch changes 18 sec0.40.61.2-0.9-1.0-1.1-0.7-1.0-0.6-0.5-0.8-0.4-0.4
Patch foraging total patch changes 24 sec1.83.13.5-1.7-1.8-1.9-1.9-1.8-1.7-1.5-1.8-1.8-1.7
Patch foraging total patch changes 6 sec0.91.42.0-1.1-1.3-1.4-1.2-1.4-1.2-1.2-0.7-1.0-1.2
Patch foraging time to switch 0 sec0.61.33.0-1.7-1.6-1.3-0.8-1.5-0.6-1.10.80.0-0.2
Patch foraging water rate 0 sec2.04.27.02.62.62.51.92.61.92.20.01.11.3
Patch foraging water rate 12 sec3.77.815.23.93.73.52.73.52.12.80.41.51.5
Patch foraging water rate 18 sec1.62.54.72.22.12.01.61.91.31.40.71.00.8
Patch foraging water rate 24 sec2.63.66.22.42.52.41.92.31.71.90.41.21.1
Patch foraging water rate 6 sec2.23.26.52.62.42.31.82.31.51.60.10.90.7
Seeking ratio, delayed vs. immediate footshock0.20.20.40.20.50.50.50.60.30.10.20.60.7
Distance traveled before self-admin0.20.30.9-1.0-0.8-0.7-0.5-0.8-0.3-0.40.3-0.00.1
Distance traveled after self-admin0.20.30.9-0.4-0.5-0.3-0.6-0.3-0.6-0.3-0.9-0.5-0.2
Extensor digitorum longus weight6.826.835.6-5.8-5.9-5.9-5.3-6.0-4.9-5.5-2.7-4.3-4.6
Bone: elastic displacement0.40.41.01.00.90.80.30.80.10.4-0.8-0.3-0.3
Bone: elastic work1.62.13.5-1.0-1.1-1.3-1.5-1.3-1.6-1.6-1.4-1.7-1.9
Bone: endosteal estimation1.73.610.01.11.31.42.00.92.11.43.22.51.9
Bone: endosteal perimeter2.55.413.11.41.61.82.41.32.62.03.63.02.5
Epididymis fat weight3.813.116.73.33.53.63.83.44.13.83.53.73.6
Delta time in closed arm before/after self-admin0.70.71.6-0.4-0.5-0.6-0.7-0.8-1.0-1.1-0.5-0.9-1.3
Delta time in open arm before/after self-admin0.10.10.2-0.3-0.4-0.4-0.3-0.20.10.3-0.4-0.00.3
Diff in mean of infusions in LGA sessions0.60.70.9-0.8-0.8-0.8-1.0-0.9-0.9-0.8-0.7-0.9-1.0
Delay discount exponential model param0.00.00.1-0.00.00.10.00.20.30.2-0.3-0.00.1
Extinction: sum of active levers before priming1.71.92.9-1.6-1.7-1.7-1.4-1.7-1.3-1.4-0.6-0.9-0.9
Active lever presses in extinction session 62.42.43.9-2.0-1.9-1.9-1.6-2.0-1.1-1.4-0.8-1.1-1.2
Bone: final force1.82.84.6-2.1-2.1-1.9-1.7-2.1-1.4-1.8-0.2-1.1-1.4
Bone: final moment1.62.64.4-2.0-2.0-1.9-1.6-2.1-1.4-1.7-0.2-1.1-1.4
Food consumed during 24 hour testing period0.10.10.4-0.3-0.2-0.1-0.30.1-0.10.1-0.6-0.4-0.1
Glucose3.04.67.01.92.02.02.41.82.31.72.72.52.1
Heart weight1.01.53.81.21.10.91.40.51.20.62.01.60.9
Delay discount hyperbolic model param0.00.00.2-0.10.00.1-0.00.20.20.2-0.5-0.1-0.0
Intermittent access intake day 1-15 change1.02.13.21.41.41.51.41.61.61.80.71.31.5
Intermittent access intake escalation0.91.82.91.31.31.41.31.41.51.70.71.11.4
Intermittent access intake escalation 21.41.62.61.21.21.31.21.41.41.60.71.11.4
Intermitt. access day 1 inactive lever presses0.10.20.40.60.50.50.30.60.20.60.10.20.5
Intermitt. access day 15 inactive lever presses2.04.15.01.71.82.02.01.92.12.02.22.12.2
Intermitt. access escalation Index2.33.24.52.12.02.01.92.01.71.80.91.61.6
Intermittent access day 1 total infusions4.47.116.52.01.92.12.81.92.92.14.13.22.9
Intermittent access day 15 total infusions7.411.113.92.92.93.13.43.03.73.33.73.53.5
Intermittent access terminal intake (last 3 days)7.910.516.82.72.62.83.32.63.73.14.13.63.5
Intermittent access total infusions7.18.415.82.32.32.43.02.23.32.64.03.33.1
Intermittent access day 1 locomotion3.74.79.21.71.71.82.31.72.41.83.02.52.3
Intermittent access day 15 total locomotion5.39.712.12.72.62.83.12.83.53.13.53.33.5
Intermittent access total locomotion11.914.320.83.13.13.33.93.24.33.64.64.24.2
Intermittent access standard deviation1.12.22.81.61.51.61.51.51.61.71.21.31.4
Left kidney weight0.83.64.91.81.71.72.01.41.92.02.22.22.0
Right kidney weight0.31.61.91.11.11.21.31.11.31.41.41.31.2
Cocaine induced anxiety0.00.00.1-0.1-0.1-0.0-0.0-0.00.00.10.20.10.2
Post-drug Anxiety0.50.50.8-0.9-0.9-0.8-0.7-0.8-0.7-0.7-0.0-0.5-0.5
Baseline Anxiety0.70.81.3-0.7-0.7-0.7-0.9-0.8-1.0-0.9-0.7-1.0-1.1
Tail length0.93.65.0-1.5-1.5-1.6-2.0-1.5-2.2-1.7-2.2-2.2-2.2
Length with tail2.310.111.6-3.1-3.1-3.2-3.3-3.3-3.4-3.3-2.2-3.2-3.4
Length without tail2.57.99.8-2.7-2.7-2.9-2.9-2.9-3.0-3.1-1.8-2.9-3.1
Times rat made contact with spout0.80.91.3-0.7-0.8-0.9-1.0-0.8-1.1-1.0-1.1-1.0-0.9
Lifetime Intake5.06.112.51.91.92.02.61.82.82.13.52.82.5
Liver weight, left0.60.91.61.31.11.01.10.90.90.81.00.90.5
Liver weight, right1.42.44.02.02.01.81.71.41.41.21.51.30.8
Locomotor activity1.01.63.61.91.81.51.21.60.91.10.10.50.4
Locomotor testing distance1.01.84.32.12.01.61.31.61.01.10.10.50.3
Locomotor testing rearing0.91.73.92.02.01.61.31.61.01.10.30.60.4
Locomotion in novel chamber5.97.58.92.72.82.82.92.83.02.82.32.72.7
Locomotion in novel chamber post-restriction3.25.25.82.22.32.42.32.42.42.41.92.22.3
Fecal boli incidents, locomotor time 10.10.20.50.1-0.00.10.2-0.00.50.70.50.50.7
Change in fecal boli incidents, locomotor task0.10.10.5-0.10.00.00.0-0.1-0.1-0.70.2-0.1-0.4
Time >=10cm from walls, locomotor time 12.52.75.90.80.81.11.60.91.91.52.42.22.0
Bouts of movement, locomotor time 12.22.57.7-1.7-1.4-1.2-1.7-0.8-1.5-1.5-2.8-1.7-1.0
Total resting periods, locomotor time 11.31.55.4-1.3-1.1-0.9-1.2-0.6-1.0-1.0-2.3-1.2-0.6
Rest time, locomotor task time 11.21.52.31.21.31.31.31.41.51.30.31.11.2
Distance moved, locomotor task time 10.10.10.6-0.1-0.4-0.4-0.1-0.5-0.3-0.20.70.2-0.1
Vertical activity count, locomotor time 10.51.22.01.21.11.11.11.10.90.91.41.00.8
Time >=10cm from walls, locomotor time 20.00.10.3-0.3-0.30.0-0.00.10.20.3-0.10.20.5
Bouts of movement, locomotor time 20.40.61.0-0.8-0.7-0.7-0.8-0.5-0.8-0.8-1.0-0.8-0.5
Total resting periods, locomotor time 20.10.20.4-0.5-0.4-0.4-0.4-0.2-0.4-0.5-0.6-0.4-0.1
Rest time, locomotor task time 22.32.93.51.71.71.71.91.71.81.51.61.81.7
Distance moved, locomotor task time 21.51.72.2-1.3-1.3-1.3-1.4-1.2-1.5-1.2-1.4-1.4-1.3
Vertical activity count, locomotor time 20.20.30.90.00.0-0.1-0.5-0.0-0.7-0.4-0.9-0.9-0.9
Light reinforcement 10.00.10.20.30.30.30.10.4-0.20.4-0.5-0.2-0.0
Light reinforcement 21.32.02.90.91.11.51.41.41.51.71.51.41.6
Bone: marrow area1.73.810.21.21.41.52.10.92.11.53.22.62.0
Bone: maximum diameter0.10.20.9-0.5-0.4-0.2-0.0-0.50.40.10.90.40.3
Bone: maximum force1.83.26.3-2.5-2.4-2.2-1.6-2.5-1.2-1.90.7-0.7-1.0
Bone: maximum moment1.73.05.7-2.4-2.3-2.1-1.5-2.4-1.1-1.80.6-0.7-1.0
Mean time between licks in bursts0.51.22.1-0.6-0.6-0.8-1.0-0.9-1.3-1.4-1.2-1.2-1.5
Mean num. licks in bursts0.10.10.30.60.40.30.20.4-0.00.1-0.3-0.0-0.0
Cd content in liver1.82.02.81.21.31.41.41.41.61.71.01.41.6
Co content in liver0.60.71.61.21.10.90.31.1-0.10.6-1.3-0.5-0.2
Cu content in liver0.00.00.20.20.20.20.20.30.00.2-0.30.20.4
Fe content in liver0.10.20.4-0.4-0.4-0.4-0.4-0.5-0.2-0.40.2-0.3-0.6
K content in liver0.40.41.1-0.6-0.7-0.8-0.5-1.0-0.6-0.80.1-0.3-0.6
Mg content in liver0.20.20.40.60.60.40.50.30.30.20.40.50.3
Mn content in liver2.42.64.6-2.1-2.0-1.8-1.7-1.8-1.3-1.6-0.9-1.3-1.2
Na content in liver0.50.50.8-0.5-0.7-0.7-0.8-0.8-0.8-0.5-0.6-0.8-0.9
Rb content in liver1.51.72.91.71.61.51.41.51.11.11.01.11.0
Se content in liver0.40.50.90.40.50.60.60.61.00.90.60.80.9
Sr content in liver3.02.63.2-1.7-1.7-1.7-1.8-1.5-1.6-1.4-1.5-1.7-1.5
Zn content in liver0.40.51.0-0.5-0.5-0.7-0.7-0.6-0.9-0.7-1.0-0.7-0.6
Bone: minimum diameter1.73.17.41.11.21.31.81.01.81.42.72.32.0
Time in familiar zone, hab. session 10.40.40.60.50.50.50.70.50.70.60.60.80.7
Time in novel zone, hab. session 10.10.10.30.40.30.2-0.10.2-0.3-0.2-0.3-0.4-0.5
Total zone transitions, hab. session 10.40.61.0-1.0-1.0-0.9-0.8-0.8-0.8-0.8-0.3-0.6-0.5
Total locomotion distance, hab. session 10.50.72.00.70.60.70.90.60.90.61.41.10.9
Locomotion velocity, hab. session 10.10.20.60.20.10.20.40.10.30.10.80.60.5
Time in familiar zone, hab. session 20.30.30.90.20.1-0.2-0.4-0.4-0.5-0.5-0.8-0.7-1.0
Time in novel zone, hab. session 20.10.10.2-0.4-0.3-0.10.10.10.00.10.40.30.5
Total zone transitions, hab. session 20.91.22.0-1.4-1.4-1.3-0.8-1.4-1.0-1.40.4-0.3-0.6
Total locomotion distance, hab. session 20.20.31.5-0.0-0.00.00.4-0.20.2-0.21.20.80.4
Locomotion velocity, hab. session 20.40.52.40.20.20.30.70.10.60.11.51.10.8
Novel to familiar place preference ratio0.40.51.3-1.2-1.1-0.9-0.7-0.8-0.3-0.3-0.1-0.20.0
Novelty place preference0.20.20.6-0.7-0.7-0.5-0.3-0.4-0.00.00.00.00.3
Time in novel zone, NPP test0.10.10.4-0.6-0.6-0.5-0.3-0.4-0.1-0.00.10.00.2
Total zone transitions, NPP test1.72.43.9-2.0-1.9-1.8-1.5-1.9-1.5-1.7-0.2-1.0-1.2
Total locomotion distance, NPP test0.10.10.9-0.2-0.3-0.20.1-0.3-0.0-0.31.00.30.1
Locomotion velocity, NPP test0.10.10.5-0.3-0.3-0.20.0-0.3-0.1-0.30.70.30.1
Intraocular pressure1.11.63.51.41.21.31.01.51.41.9-0.60.81.3
Delta distance traveled before/after self-admin0.20.31.20.50.30.2-0.10.3-0.4-0.1-1.1-0.6-0.5
Delta ambulatory time before/after self-admin0.20.31.10.20.10.0-0.30.1-0.6-0.3-1.0-0.7-0.7
Parametrial fat weight4.310.211.83.03.03.03.42.93.43.23.33.43.3
Pavlov. Cond. lever latency0.20.20.40.60.60.60.40.70.30.5-0.10.10.2
Pavlov. Cond. magazine entry latency0.10.20.6-0.7-0.5-0.5-0.2-0.5-0.1-0.30.50.20.2
Pavlov. Cond. change in total contacts0.10.10.5-0.4-0.2-0.10.10.00.30.30.40.50.7
Pavlov. Cond. index score0.10.20.4-0.7-0.5-0.5-0.4-0.5-0.2-0.3-0.2-0.2-0.1
Pavlov. Cond. latency score0.10.10.3-0.5-0.4-0.4-0.2-0.4-0.1-0.30.0-0.0-0.0
Pavlov. Cond. lever contacts0.10.10.2-0.4-0.3-0.4-0.1-0.5-0.1-0.30.20.1-0.1
Pavlov. Cond. magazine entry number0.20.20.60.80.60.50.50.40.40.20.50.40.1
Pavlov. Cond. intertrial magazine entries0.60.71.20.90.91.00.71.10.81.1-0.30.50.8
Pavlov. Cond. lever-magazine prob. diff.0.20.30.7-0.8-0.7-0.7-0.5-0.6-0.3-0.4-0.2-0.2-0.1
Pavlov. Cond. response bias0.10.10.4-0.6-0.5-0.4-0.4-0.4-0.2-0.2-0.3-0.2-0.0
Pavlov. Cond. lever latency0.20.30.80.90.90.70.50.70.20.4-0.20.20.2
Pavlov. Cond. magazine entry latency3.34.05.8-2.4-2.4-2.3-2.1-2.3-2.0-2.0-1.0-1.6-1.5
Pavlov. Cond. change in total contacts0.50.92.5-1.6-1.5-1.2-0.9-1.1-0.5-0.60.0-0.3-0.0
Pavlov. Cond. index score1.31.83.6-1.9-1.9-1.6-1.4-1.7-1.0-1.2-0.3-0.8-0.7
Pavlov. Cond. latency score1.01.42.9-1.7-1.7-1.4-1.2-1.5-0.8-1.0-0.0-0.6-0.5
Pavlov. Cond. lever contacts0.20.30.9-0.9-0.9-0.7-0.6-0.8-0.2-0.40.1-0.3-0.2
Pavlov. Cond. magazine entry number5.26.410.13.23.12.92.72.82.42.41.42.01.8
Pavlov. Cond. intertrial magazine entries0.91.31.71.31.31.21.21.21.21.30.61.01.0
Pavlov. Cond. lever-magazine prob. diff.1.72.34.4-2.1-2.1-1.8-1.6-1.8-1.2-1.4-0.5-1.0-0.8
Pavlov. Cond. response bias1.31.73.2-1.8-1.8-1.6-1.4-1.6-1.0-1.2-0.4-0.9-0.8
Time in closed arm before self-admin0.70.91.50.50.60.70.90.81.01.11.11.11.2
Time in closed arm after self-admin0.30.30.50.60.60.70.60.60.40.40.50.50.4
Time in open arm before self-admin0.40.41.10.30.2-0.1-0.3-0.0-0.9-0.7-0.8-0.8-1.1
Time in open arm after self-admin0.40.41.1-0.2-0.4-0.6-0.7-0.5-0.7-0.6-1.1-0.8-0.8
Bone: periosteal estimation0.40.84.0-0.00.10.30.7-0.11.00.52.01.30.9
Bone: periosteal perimeter0.20.31.9-0.4-0.3-0.10.2-0.40.50.11.40.70.5
Bone: post-yield work1.42.19.9-0.9-0.6-0.20.8-0.61.30.13.12.11.7
Progressive ratio test 1 active lever presses0.70.82.00.60.60.70.90.71.10.81.41.01.0
Progressive ratio test 1 breakpoint0.60.82.00.60.60.60.80.61.00.81.41.01.0
Progressive ratio test 1 inactive lever presses0.10.20.30.40.30.40.40.50.40.60.30.40.6
Progressive ratio test 2 active lever presses4.24.96.51.91.92.02.22.02.62.32.52.32.4
Progressive ratio test 2 breakpoint4.24.86.41.91.92.02.22.02.52.32.42.32.4
Progressive ratio test 2 inactive lever presses8.413.615.73.53.53.73.83.74.03.93.23.73.9
Incentive Sensitization - Responses0.30.51.80.20.20.30.60.20.90.51.30.90.8
Incentive Sensitization - Breakpoint0.60.72.10.40.40.50.80.41.10.71.41.11.0
Sum of active levers in priming session hrs 5-60.70.72.0-0.9-0.9-0.7-1.0-0.6-0.3-0.0-1.4-0.9-0.4
Progressive ratio0.50.81.9-1.4-1.2-1.1-0.5-1.2-0.3-1.10.90.30.0
Food seeking constrained by brief footshock0.10.10.2-0.3-0.2-0.3-0.3-0.3-0.4-0.5-0.3-0.3-0.5
Seeking ratio, punishment vs. effort0.60.92.31.51.31.10.61.20.30.8-0.7-0.2-0.1
Retroperitoneal fat weight8.938.145.36.76.76.66.66.46.36.14.85.85.5
Reaction time number correct0.30.60.8-0.7-0.8-0.8-0.8-0.7-0.7-0.6-0.9-0.9-0.9
Reaction time mean minus median1.22.96.1-2.5-2.2-1.9-1.8-2.0-1.3-1.6-0.6-1.2-1.0
Reaction time mean minus median AUC0.71.72.9-1.7-1.6-1.5-1.4-1.4-1.0-1.2-1.0-1.1-0.9
Reaction time num false alarms0.10.20.50.70.70.40.20.4-0.1-0.1-0.5-0.2-0.4
Reaction time num false alarms AUC0.20.41.00.0-0.0-0.3-0.4-0.2-0.7-0.7-1.0-0.7-0.9
Reaction time trials correct on left0.30.60.8-0.7-0.8-0.8-0.8-0.7-0.7-0.6-0.9-0.9-0.9
Reaction time trials on left0.40.71.0-0.8-0.9-0.9-0.9-0.8-0.8-0.7-1.0-1.0-1.0
Reaction time mean0.00.00.2-0.3-0.20.0-0.00.20.10.20.20.10.5
Reaction time mean AUC0.10.10.4-0.2-0.10.10.10.30.30.30.30.30.6
Median of all reaction times0.30.40.80.40.40.60.50.70.60.70.60.60.9
Reaction time omissions1.31.83.0-1.7-1.7-1.4-1.5-1.2-1.2-1.5-1.0-1.2-0.9
Reaction time false alarm rate0.10.10.40.70.60.40.30.4-0.0-0.1-0.20.0-0.2
Reaction time premature initiation rate4.05.57.5-2.0-2.1-2.3-2.4-2.3-2.6-2.7-1.8-2.5-2.7
Reaction time premature initiations4.88.610.8-2.5-2.6-2.8-3.0-2.7-3.1-3.2-2.7-3.2-3.3
Std. dev. reaction times0.40.71.8-1.3-1.2-0.9-0.9-0.8-0.6-0.7-0.5-0.6-0.3
Reaction time trials completed0.40.71.0-0.8-0.9-0.9-0.9-0.8-0.8-0.7-1.0-1.0-1.0
Reaction time trials AUC0.30.50.8-0.6-0.7-0.7-0.7-0.6-0.6-0.6-0.8-0.8-0.9
Run reversals in cocaine runway, females0.40.40.8-0.5-0.6-0.7-0.3-0.9-0.6-0.90.5-0.1-0.6
Run reversals in cocaine runway, males0.20.20.70.80.60.40.30.40.30.5-0.1-0.1-0.2
Latency to leave start box in cocaine runway0.40.51.50.30.40.50.70.30.60.51.21.00.8
Latency to leave start box in cocaine runway, F0.10.10.30.20.10.20.30.20.10.30.50.50.5
Latency to leave start box in cocaine runway, M0.20.21.0-0.00.10.20.4-0.10.50.11.00.60.3
Std. dev. time between licks in bursts0.20.30.90.10.1-0.1-0.3-0.2-0.6-0.8-0.7-0.7-1.0
Total sessions with >9 infusions0.40.52.90.00.10.10.60.10.70.21.71.00.7
Short access day 1 total inactive lever presses2.73.64.21.91.92.02.01.92.01.61.91.81.7
Short access day 10 total inactive lever presses0.20.41.01.00.90.80.60.80.40.6-0.10.30.4
Short access day 1 total infusions2.43.26.21.41.51.51.91.42.01.42.52.11.8
Short access day 10 total infusions2.22.810.20.80.80.91.70.71.81.03.22.21.9
Short access total infusions1.62.17.90.80.80.91.50.61.60.82.81.81.4
Short access day 1 locomotion2.22.83.71.61.51.51.81.51.81.51.91.81.7
Short access day 10 total locomotion1.42.64.21.21.21.31.71.21.81.42.11.91.9
Short access total locomotion2.73.35.91.41.41.61.91.52.01.62.42.12.0
One hour access (0.3 mA shock)8.19.310.73.13.03.13.23.03.33.12.83.02.9
Compulsive drug intake4.65.49.1-1.7-1.6-1.9-2.3-1.8-2.7-2.2-3.0-2.7-2.8
One hour access (shock baseline)8.913.616.83.43.33.53.83.54.13.83.73.83.9
Social response proportion0.40.50.8-0.8-0.9-0.8-0.8-0.8-0.8-0.6-0.2-0.6-0.5
Social responses0.40.50.9-0.5-0.6-0.8-0.7-0.6-0.8-0.6-0.9-0.8-0.8
Social time0.60.81.0-0.7-0.9-0.9-0.9-0.8-0.9-0.9-1.0-1.0-1.0
Soleus weight3.711.014.73.83.73.73.53.53.23.42.03.02.9
Bone: stiffness1.22.04.4-2.1-2.0-1.7-1.3-1.9-0.9-1.40.5-0.5-0.6
Tibialis anterior weight9.632.740.9-6.2-6.4-6.3-6.0-6.2-5.3-5.7-3.9-5.2-5.3
Time to tail flick, vehicle, before self-admin0.20.20.9-0.6-0.5-0.4-0.1-0.5-0.0-0.31.00.20.0
Time to tail flick, vehicle, after self-admin0.50.72.0-0.8-0.9-1.1-0.5-1.4-0.5-1.00.60.0-0.5
Time to tail flick, test, before self-admin2.32.33.31.41.51.41.81.31.51.21.81.81.5
Time to tail flick, test, after self-admin0.00.00.1-0.2-0.3-0.3-0.2-0.30.10.1-0.1-0.0-0.0
Delta time to tail flick, vehicle, before/after SA0.50.41.0-0.5-0.6-0.8-0.5-1.0-0.6-0.9-0.3-0.3-0.6
Delta time to tail flick, test, before/after SA2.42.55.2-1.4-1.4-1.4-1.8-1.1-1.5-0.9-2.3-2.0-1.5
Tibia length0.41.22.6-1.6-1.6-1.3-1.2-1.3-0.6-0.5-0.5-0.7-0.4
Ambulatory time before self-admin0.10.20.5-0.7-0.6-0.5-0.2-0.50.1-0.10.40.30.4
Ambulatory time after self-admin0.40.40.90.50.50.60.60.70.60.80.30.71.0
Bone: tissue strength0.00.00.1-0.10.00.10.10.10.30.10.00.20.3
Total heroin consumption5.15.97.1-2.5-2.7-2.6-2.6-2.6-2.4-2.4-2.2-2.2-2.1
Bone: trabecular number0.30.51.1-1.0-1.0-0.9-0.4-1.0-0.2-0.50.80.20.1
Bone: trabecular spacing0.20.20.50.70.60.50.30.60.10.2-0.7-0.1-0.1
Bone: trabecular thickness0.70.91.50.80.70.81.00.70.90.81.21.11.1
Bone: trabecular tissue density3.75.57.22.72.72.62.42.62.22.61.01.92.1
Water consumed over 24 hours1.52.13.0-1.2-1.3-1.3-1.6-1.1-1.6-1.3-1.7-1.6-1.4
Number of responses in last shaping day0.10.10.40.10.10.0-0.20.0-0.3-0.1-0.6-0.4-0.4