Hub : Genes

Bin3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA mRNA stability Bin3 0.05 0.05 6.8e-04 0.04 0.04 0.04 0.04 2.2e-04 3.1e-04 2.7e-04 3.1e-04
2 NAcc mRNA stability Bin3 0.09 0.08 3.3e-11 0.08 0.07 0.07 0.07 1.5e-11 2.7e-11 3.3e-11 2.8e-11
3 Liver mRNA stability Bin3 0.19 0.13 0.0e+00 0.18 0.18 0.18 0.18 2.9e-19 9.8e-20 2.2e-19 1.9e-19
4 Brain mRNA stability Bin3 0.11 0.1 1.1e-08 0.09 0.09 0.09 0.09 1.4e-08 7.1e-09 1.5e-08 1.6e-08
5 IC intron excision ratio chr15_51561238_51562057 0.07 0.08 8.8e-03 0.01 -0 -0.01 -0 1.6e-01 4.0e-01 6.6e-01 3.8e-01
6 PL mRNA stability Bin3 0.07 0.06 3.0e-06 0.05 0.05 0.05 0.05 3.2e-06 4.4e-06 8.2e-06 4.0e-06
7 IC mRNA stability Bin3 0.13 0.12 2.1e-04 0.1 0.09 0.1 0.1 3.9e-05 1.7e-04 6.2e-05 6.3e-05
8 OFC mRNA stability Bin3 0.16 0.15 6.3e-03 0.07 0.05 0.03 0.06 7.6e-03 2.5e-02 5.9e-02 1.5e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density1.22.02.2-1.4-1.5-1.4-1.41.4-1.4-1.3-1.3
Area under the delay curve0.10.10.20.20.30.30.3-0.40.30.30.3
BMI with tail0.41.41.61.21.31.21.2-1.21.21.11.1
BMI without tail0.00.00.10.00.1-0.0-0.0-0.0-0.1-0.3-0.3
Body weight0.72.93.11.71.81.71.7-1.71.81.61.6
Weight adjusted by age1.42.22.41.51.41.51.5-1.41.51.51.5
Bone surface0.50.91.1-1.0-1.1-1.0-1.01.1-1.0-0.7-0.7
Bone volume0.61.11.3-1.1-1.1-1.1-1.11.1-1.1-0.9-0.9
Breakpoint value in progressive ratio session0.10.10.20.30.50.30.3-0.10.30.30.3
Number of licking bursts0.00.00.0-0.0-0.1-0.0-0.00.0-0.0-0.1-0.1
Context. condit. distance diff. score1.01.21.5-1.0-1.0-1.0-1.01.0-1.1-1.2-1.2
Locomotion velocity, session 10.20.20.30.40.50.50.5-0.40.40.50.5
Locomotion distance, session 10.00.00.1-0.2-0.1-0.1-0.10.2-0.2-0.3-0.3
Locomotion velocity, session 20.00.00.1-0.2-0.1-0.2-0.20.3-0.2-0.2-0.2
Locomotion distance, session 20.00.00.1-0.2-0.1-0.1-0.10.3-0.1-0.2-0.2
Locomotion velocity, session 30.50.60.70.70.80.80.8-0.70.70.80.8
Locomotion distance, session 30.00.00.0-0.2-0.1-0.2-0.20.2-0.2-0.1-0.1
Stereotopy head waving bouts, day 30.70.80.90.91.00.90.9-0.90.90.80.8
Stereotopy head waving duration, day 32.42.93.01.71.71.71.7-1.71.71.61.6
Locomotion velocity, session 74.14.54.7-2.1-2.1-2.1-2.12.2-2.1-2.1-2.1
Locomotion distance, session 73.24.14.4-2.0-2.0-2.0-2.02.1-2.0-2.0-2.0
Stereotopy head waving bouts, day 71.61.81.91.41.31.31.3-1.41.41.41.4
Stereotopy head waving duration, day 72.32.73.01.71.51.61.6-1.71.61.71.7
Locomotion velocity, session 80.00.00.0-0.10.0-0.0-0.00.2-0.0-0.0-0.0
Locomotion distance, session 80.71.11.4-1.0-0.9-1.0-1.01.1-1.0-1.2-1.2
Degree of sensitization distance4.44.54.8-2.1-2.1-2.1-2.12.2-2.1-2.1-2.1
Degree of sensitization stereotypy1.11.21.31.21.01.11.1-1.11.11.11.1
Conditioned locomotion0.00.00.0-0.2-0.2-0.2-0.20.2-0.2-0.2-0.2
Cocaine response after cond. corrected0.20.30.30.50.60.60.6-0.50.50.50.5
Cocaine response after cond. not corrected0.20.20.20.40.40.40.4-0.40.40.40.4
Cocaine response before conditioning0.20.20.2-0.4-0.4-0.4-0.40.4-0.4-0.5-0.5
Saline control response0.10.10.1-0.4-0.3-0.4-0.40.4-0.4-0.2-0.2
Bone: connectivity density2.43.74.0-1.9-2.0-2.0-2.01.9-1.9-1.9-1.9
Bone: cortical apparent density0.10.10.1-0.3-0.3-0.3-0.30.4-0.3-0.3-0.3
Bone: cortical area0.00.00.00.0-0.0-0.0-0.00.10.00.10.1
Bone: cortical porosity1.21.31.31.11.11.11.1-1.11.11.11.1
Bone: cortical porosity0.70.70.70.90.90.90.9-0.80.90.80.8
Bone: cortical thickness0.00.00.0-0.0-0.0-0.0-0.00.2-0.00.10.1
Bone: cortical thickness0.00.00.1-0.0-0.0-0.0-0.00.1-0.0-0.3-0.3
Bone: cortical tissue density0.10.10.2-0.3-0.3-0.3-0.30.4-0.3-0.4-0.4
Condit. Reinf. active minus inactive responses0.40.50.60.70.70.70.8-0.60.70.60.6
Condit. Reinf. active-inactive response ratio2.12.32.51.51.51.61.6-1.41.51.41.4
Condit. Reinf. active responses0.00.00.0-0.00.10.00.00.00.0-0.0-0.0
Condit. Reinf. inactive responses2.43.03.2-1.8-1.7-1.7-1.71.7-1.7-1.7-1.7
Incentive salience index mean0.60.80.90.91.01.01.0-0.80.90.80.8
Condit. Reinf. lever presses0.20.30.40.50.70.60.6-0.50.60.40.4
Condit. Reinf. active minus inactive responses0.30.40.4-0.7-0.7-0.7-0.70.7-0.7-0.6-0.6
Condit. Reinf. active-inactive response ratio0.10.10.10.20.20.30.3-0.20.20.30.3
Condit. Reinf. active responses0.91.21.2-1.1-1.1-1.1-1.11.1-1.1-1.1-1.1
Condit. Reinf. inactive responses2.02.62.7-1.6-1.6-1.6-1.61.6-1.6-1.7-1.7
Condit. Reinf. lever presses0.20.20.3-0.4-0.5-0.4-0.40.4-0.4-0.6-0.6
Condit. Reinf. lever reinforcers received0.70.90.9-1.0-1.0-1.0-1.01.0-1.0-0.9-0.9
Conditioned reinforcement - actives1.01.71.8-1.3-1.3-1.3-1.31.3-1.3-1.3-1.3
Conditioned reinforcement - inactives3.24.74.9-2.2-2.2-2.2-2.22.2-2.1-2.2-2.2
Conditioned locomotion0.20.20.3-0.5-0.5-0.4-0.40.5-0.4-0.4-0.4
Patch foraging indifference point 0 sec1.52.73.1-1.8-1.8-1.8-1.81.8-1.7-1.2-1.2
Patch foraging indifference point AUC0.20.30.40.50.60.60.6-0.60.50.50.5
Delay disc. indifference point, 0s delay0.30.40.4-0.6-0.6-0.6-0.60.5-0.7-0.6-0.6
Delay disc. indifference point, 16s delay0.20.20.3-0.5-0.5-0.5-0.50.4-0.5-0.5-0.5
Delay disc. indifference point, 2s delay1.51.61.91.31.31.31.3-1.41.31.31.3
Delay disc. indifference point, 24s delay0.20.20.40.40.40.40.4-0.60.50.40.4
Delay disc. indifference point, 4s delay1.81.91.91.31.41.41.4-1.41.31.41.4
Delay disc. indifference point, 8s delay0.00.00.0-0.2-0.1-0.2-0.20.0-0.2-0.2-0.2
Indifference point function ln k0.00.00.0-0.0-0.1-0.0-0.10.0-0.0-0.2-0.2
Indifference point function log k0.00.00.0-0.0-0.1-0.0-0.10.0-0.0-0.2-0.2
Patch foraging total patch changes 0 sec1.01.92.3-1.5-1.5-1.5-1.51.5-1.4-1.0-1.0
Patch foraging total patch changes 12 sec0.50.70.9-0.9-0.9-0.9-0.90.8-0.9-0.5-0.5
Patch foraging total patch changes 18 sec1.21.92.1-1.4-1.3-1.4-1.41.4-1.4-1.2-1.2
Patch foraging total patch changes 24 sec0.00.00.10.00.10.00.0-0.10.00.30.3
Patch foraging total patch changes 6 sec0.20.20.3-0.5-0.5-0.6-0.60.5-0.6-0.3-0.3
Patch foraging time to switch 0 sec0.61.11.2-1.1-1.1-1.1-1.11.1-1.0-1.1-1.1
Patch foraging water rate 0 sec0.30.50.60.70.70.70.7-0.80.80.70.7
Patch foraging water rate 12 sec0.51.01.11.01.01.01.0-1.01.01.01.0
Patch foraging water rate 18 sec2.74.24.52.12.02.02.0-2.12.12.02.0
Patch foraging water rate 24 sec0.10.20.30.50.40.50.4-0.60.50.30.3
Patch foraging water rate 6 sec2.02.93.11.71.71.71.7-1.71.71.81.8
Seeking ratio, delayed vs. immediate footshock1.01.21.8-1.0-1.4-1.1-1.11.0-1.0-1.1-1.1
Distance traveled before self-admin0.70.91.01.00.81.01.0-0.91.01.01.0
Distance traveled after self-admin2.53.13.31.81.71.81.8-1.61.81.81.8
Extensor digitorum longus weight12.950.651.67.27.27.27.1-7.17.17.07.0
Bone: elastic displacement0.40.50.6-0.7-0.7-0.7-0.70.7-0.7-0.8-0.8
Bone: elastic work0.20.30.3-0.5-0.5-0.5-0.50.6-0.5-0.5-0.5
Bone: endosteal estimation0.10.20.20.40.30.30.3-0.40.40.50.5
Bone: endosteal perimeter0.00.10.20.30.20.20.2-0.30.30.40.4
Epididymis fat weight0.82.83.5-1.6-1.5-1.6-1.61.7-1.6-1.9-1.9
Delta time in closed arm before/after self-admin4.23.94.2-2.0-2.1-2.0-2.01.9-1.9-2.0-2.0
Delta time in open arm before/after self-admin0.10.10.10.30.20.30.3-0.10.20.30.3
Diff in mean of infusions in LGA sessions0.91.11.21.11.11.11.1-0.71.01.11.1
Delay discount exponential model param0.40.40.6-0.6-0.7-0.6-0.60.8-0.6-0.6-0.6
Extinction: sum of active levers before priming2.12.32.3-1.5-1.5-1.5-1.51.5-1.5-1.5-1.5
Active lever presses in extinction session 60.60.60.8-0.9-0.8-0.8-0.80.8-0.8-0.8-0.8
Bone: final force0.10.20.20.40.40.40.4-0.30.40.50.5
Bone: final moment0.10.10.20.40.30.30.3-0.30.40.40.4
Food consumed during 24 hour testing period0.30.40.5-0.6-0.6-0.6-0.60.6-0.6-0.7-0.7
Glucose0.00.00.00.0-0.1-0.0-0.00.0-0.00.10.1
Heart weight0.40.50.8-0.8-0.9-0.8-0.80.8-0.8-0.5-0.5
Delay discount hyperbolic model param0.50.50.7-0.7-0.8-0.7-0.70.8-0.7-0.7-0.7
Intermittent access intake day 1-15 change1.73.53.7-1.9-1.8-1.9-1.91.9-1.9-1.9-1.9
Intermittent access intake escalation1.83.73.9-2.0-1.9-1.9-1.92.0-1.9-1.9-1.9
Intermittent access intake escalation 21.51.71.8-1.3-1.3-1.3-1.31.3-1.3-1.3-1.3
Intermitt. access day 1 inactive lever presses0.00.00.0-0.1-0.2-0.1-0.10.1-0.1-0.1-0.1
Intermitt. access day 15 inactive lever presses0.00.10.1-0.2-0.3-0.2-0.20.2-0.2-0.2-0.2
Intermitt. access escalation Index0.00.00.10.20.30.20.2-0.20.20.20.2
Intermittent access day 1 total infusions0.00.00.00.0-0.20.00.0-0.00.00.00.0
Intermittent access day 15 total infusions1.72.63.0-1.6-1.7-1.6-1.61.6-1.6-1.6-1.6
Intermittent access terminal intake (last 3 days)1.11.51.8-1.2-1.3-1.2-1.21.2-1.2-1.2-1.2
Intermittent access total infusions1.31.51.7-1.2-1.3-1.2-1.21.2-1.2-1.2-1.2
Intermittent access day 1 locomotion0.00.00.0-0.1-0.1-0.1-0.10.1-0.1-0.1-0.1
Intermittent access day 15 total locomotion0.30.50.6-0.7-0.8-0.6-0.60.7-0.6-0.6-0.6
Intermittent access total locomotion0.10.10.2-0.4-0.4-0.3-0.30.4-0.3-0.3-0.3
Intermittent access standard deviation0.20.30.4-0.6-0.5-0.6-0.60.6-0.5-0.6-0.6
Left kidney weight0.00.20.20.50.40.40.4-0.40.50.40.4
Right kidney weight0.00.20.40.30.30.30.3-0.30.30.70.7
Cocaine induced anxiety0.00.00.00.00.00.10.1-0.00.00.10.1
Post-drug Anxiety0.91.01.0-1.0-1.0-1.0-1.01.0-1.0-1.0-1.0
Baseline Anxiety0.40.50.5-0.7-0.7-0.7-0.70.7-0.7-0.7-0.7
Tail length0.51.82.0-1.4-1.3-1.4-1.41.4-1.4-1.3-1.3
Length with tail0.10.30.40.50.40.40.4-0.50.50.60.6
Length without tail2.37.58.22.72.62.72.7-2.72.72.92.9
Times rat made contact with spout0.60.70.8-0.8-0.8-0.8-0.80.8-0.8-0.9-0.9
Lifetime Intake0.70.91.1-1.0-1.1-0.9-0.91.0-0.9-0.9-0.9
Liver weight, left1.72.93.51.81.91.71.7-1.81.71.51.5
Liver weight, right0.40.81.10.91.00.90.9-0.90.90.60.6
Locomotor activity1.62.42.61.61.41.61.6-1.61.61.61.6
Locomotor testing distance0.00.00.1-0.2-0.3-0.2-0.20.2-0.2-0.2-0.2
Locomotor testing rearing0.10.20.3-0.5-0.5-0.5-0.50.4-0.5-0.4-0.4
Locomotion in novel chamber0.50.60.7-0.8-0.8-0.8-0.80.8-0.8-0.8-0.8
Locomotion in novel chamber post-restriction0.71.11.31.10.81.11.1-1.21.11.11.1
Fecal boli incidents, locomotor time 11.01.41.81.11.31.21.2-1.11.21.21.2
Change in fecal boli incidents, locomotor task0.20.20.30.50.40.50.5-0.50.50.50.5
Time >=10cm from walls, locomotor time 11.01.11.2-1.1-0.9-1.0-1.01.1-1.0-1.0-1.0
Bouts of movement, locomotor time 14.75.35.92.32.42.32.3-2.32.22.32.3
Total resting periods, locomotor time 14.65.15.72.22.42.32.3-2.32.22.32.3
Rest time, locomotor task time 11.92.32.51.61.61.51.5-1.61.41.51.5
Distance moved, locomotor task time 12.33.43.7-1.9-1.8-1.8-1.81.9-1.8-1.8-1.8
Vertical activity count, locomotor time 10.51.11.4-1.0-1.2-1.1-1.11.0-1.0-1.1-1.1
Time >=10cm from walls, locomotor time 20.30.50.70.80.60.70.7-0.80.60.70.7
Bouts of movement, locomotor time 23.25.15.42.22.32.32.3-2.32.22.32.3
Total resting periods, locomotor time 23.25.65.72.42.42.42.4-2.42.32.42.4
Rest time, locomotor task time 21.01.21.61.21.01.11.1-1.31.01.11.1
Distance moved, locomotor task time 23.13.73.9-2.0-1.9-1.9-1.92.0-1.9-1.9-1.9
Vertical activity count, locomotor time 20.40.50.5-0.7-0.7-0.7-0.70.7-0.7-0.7-0.7
Light reinforcement 12.25.46.5-2.3-2.3-2.3-2.32.3-2.2-2.5-2.5
Light reinforcement 20.91.41.8-1.1-1.1-1.1-1.11.1-1.1-1.3-1.3
Bone: marrow area0.00.10.10.20.20.20.2-0.20.20.40.4
Bone: maximum diameter0.40.71.00.80.80.80.8-0.70.81.01.0
Bone: maximum force0.30.50.70.70.70.70.7-0.60.70.90.9
Bone: maximum moment0.20.40.50.60.50.50.5-0.40.60.70.7
Mean time between licks in bursts1.23.04.1-1.6-1.7-1.6-1.61.6-1.6-2.0-2.0
Mean num. licks in bursts0.20.30.3-0.6-0.5-0.6-0.60.6-0.6-0.6-0.6
Cd content in liver1.21.31.51.11.11.11.1-1.11.11.21.2
Co content in liver5.15.96.32.42.42.42.4-2.42.42.52.5
Cu content in liver0.40.50.60.60.70.70.7-0.60.60.80.8
Fe content in liver1.51.82.0-1.4-1.4-1.4-1.41.4-1.4-1.1-1.1
K content in liver1.11.11.2-1.1-1.1-1.1-1.11.1-1.1-1.0-1.0
Mg content in liver2.72.72.8-1.7-1.7-1.7-1.71.7-1.7-1.6-1.6
Mn content in liver2.52.72.8-1.7-1.7-1.7-1.71.7-1.7-1.6-1.6
Na content in liver1.01.11.31.01.01.01.0-1.01.01.11.1
Rb content in liver0.00.00.0-0.2-0.2-0.2-0.20.2-0.2-0.0-0.0
Se content in liver1.01.11.2-1.1-1.1-1.1-1.11.1-1.1-1.0-1.0
Sr content in liver0.00.00.0-0.2-0.1-0.1-0.10.2-0.20.00.0
Zn content in liver0.10.10.2-0.4-0.4-0.4-0.40.4-0.4-0.2-0.2
Bone: minimum diameter0.20.30.40.50.50.50.5-0.50.50.70.7
Time in familiar zone, hab. session 10.00.00.10.20.10.20.2-0.10.20.20.2
Time in novel zone, hab. session 11.21.21.31.11.11.11.1-1.11.11.11.1
Total zone transitions, hab. session 10.10.20.30.40.60.50.5-0.40.50.40.4
Total locomotion distance, hab. session 10.00.00.0-0.10.0-0.1-0.00.1-0.1-0.1-0.1
Locomotion velocity, hab. session 10.10.10.2-0.4-0.3-0.3-0.30.4-0.4-0.4-0.4
Time in familiar zone, hab. session 21.92.02.21.41.51.51.5-1.31.51.41.4
Time in novel zone, hab. session 20.70.70.8-0.9-0.9-0.9-0.90.7-0.9-0.8-0.8
Total zone transitions, hab. session 21.31.61.81.31.31.31.3-1.31.31.11.1
Total locomotion distance, hab. session 20.20.30.30.50.60.50.5-0.50.50.40.4
Locomotion velocity, hab. session 20.50.70.80.80.90.90.9-0.80.80.70.7
Novel to familiar place preference ratio1.51.61.7-1.3-1.3-1.3-1.31.1-1.3-1.3-1.3
Novelty place preference1.21.21.3-1.1-1.2-1.1-1.11.0-1.1-1.1-1.1
Time in novel zone, NPP test0.60.60.7-0.8-0.8-0.8-0.80.7-0.8-0.8-0.8
Total zone transitions, NPP test0.20.30.4-0.5-0.4-0.5-0.50.5-0.5-0.6-0.6
Total locomotion distance, NPP test2.73.73.9-1.9-1.9-1.9-1.91.9-1.9-2.0-2.0
Locomotion velocity, NPP test2.63.63.9-1.9-1.8-1.9-1.91.9-1.9-2.0-2.0
Intraocular pressure0.60.91.5-0.8-0.9-0.8-0.80.9-0.8-1.2-1.2
Delta distance traveled before/after self-admin3.03.23.61.81.91.81.8-1.81.81.81.8
Delta ambulatory time before/after self-admin2.83.53.71.81.91.81.8-1.91.91.91.9
Parametrial fat weight1.84.24.8-2.0-2.2-2.1-2.12.1-2.0-1.9-1.9
Pavlov. Cond. lever latency0.00.00.00.0-0.0-0.0-0.0-0.1-0.00.10.1
Pavlov. Cond. magazine entry latency0.00.00.1-0.2-0.1-0.2-0.20.3-0.2-0.2-0.2
Pavlov. Cond. change in total contacts1.01.11.41.01.21.11.1-1.01.10.90.9
Pavlov. Cond. index score0.10.10.10.20.30.30.3-0.10.30.20.2
Pavlov. Cond. latency score0.00.00.00.10.20.20.2-0.00.20.10.1
Pavlov. Cond. lever contacts0.00.00.1-0.1-0.1-0.1-0.10.2-0.1-0.2-0.2
Pavlov. Cond. magazine entry number0.30.40.5-0.6-0.7-0.7-0.70.6-0.7-0.6-0.6
Pavlov. Cond. intertrial magazine entries0.10.10.1-0.3-0.4-0.4-0.40.3-0.4-0.2-0.2
Pavlov. Cond. lever-magazine prob. diff.0.20.20.30.40.50.50.5-0.30.50.40.4
Pavlov. Cond. response bias0.10.10.20.40.50.40.4-0.30.40.30.3
Pavlov. Cond. lever latency0.30.50.5-0.7-0.7-0.7-0.70.7-0.7-0.6-0.6
Pavlov. Cond. magazine entry latency0.10.10.1-0.3-0.3-0.3-0.30.3-0.3-0.3-0.3
Pavlov. Cond. change in total contacts1.11.71.91.41.31.41.4-1.41.41.21.2
Pavlov. Cond. index score0.30.40.50.70.60.70.7-0.70.70.60.6
Pavlov. Cond. latency score0.20.30.30.60.50.60.6-0.60.60.40.4
Pavlov. Cond. lever contacts0.10.20.20.50.40.50.5-0.50.50.30.3
Pavlov. Cond. magazine entry number0.00.00.10.20.20.20.2-0.20.20.30.3
Pavlov. Cond. intertrial magazine entries5.27.98.2-2.8-2.8-2.8-2.82.8-2.8-2.9-2.9
Pavlov. Cond. lever-magazine prob. diff.0.40.60.60.80.70.80.8-0.80.80.60.6
Pavlov. Cond. response bias0.20.20.30.50.50.50.5-0.50.50.40.4
Time in closed arm before self-admin1.62.12.31.51.51.41.4-1.51.41.41.4
Time in closed arm after self-admin0.00.00.10.20.10.20.2-0.30.20.20.2
Time in open arm before self-admin0.00.00.0-0.1-0.1-0.0-0.00.0-0.0-0.0-0.0
Time in open arm after self-admin0.00.00.1-0.2-0.1-0.2-0.20.3-0.2-0.2-0.2
Bone: periosteal estimation0.10.10.20.30.20.30.3-0.20.30.50.5
Bone: periosteal perimeter0.00.10.20.20.20.20.2-0.30.20.40.4
Bone: post-yield work0.10.20.3-0.4-0.4-0.4-0.40.5-0.4-0.5-0.5
Progressive ratio test 1 active lever presses0.10.10.10.30.30.30.3-0.30.30.30.3
Progressive ratio test 1 breakpoint0.10.20.20.40.30.40.4-0.40.40.40.4
Progressive ratio test 1 inactive lever presses0.91.21.7-1.1-1.3-1.1-1.11.1-1.1-1.1-1.1
Progressive ratio test 2 active lever presses0.00.00.1-0.2-0.3-0.2-0.20.2-0.2-0.2-0.2
Progressive ratio test 2 breakpoint0.00.00.1-0.2-0.3-0.1-0.10.2-0.1-0.1-0.1
Progressive ratio test 2 inactive lever presses0.30.50.6-0.7-0.8-0.7-0.70.7-0.6-0.7-0.7
Incentive Sensitization - Responses0.20.30.4-0.6-0.6-0.6-0.60.6-0.6-0.6-0.6
Incentive Sensitization - Breakpoint0.40.50.5-0.7-0.7-0.7-0.70.7-0.7-0.7-0.7
Sum of active levers in priming session hrs 5-60.10.10.2-0.4-0.3-0.3-0.30.4-0.3-0.3-0.3
Progressive ratio0.00.00.00.10.10.10.1-0.10.10.10.1
Food seeking constrained by brief footshock2.12.62.91.71.51.61.6-1.61.61.61.6
Seeking ratio, punishment vs. effort0.71.01.11.00.91.01.0-1.01.01.01.0
Retroperitoneal fat weight0.10.30.5-0.7-0.6-0.7-0.70.6-0.6-0.3-0.3
Reaction time number correct0.50.91.11.11.01.01.0-1.11.00.80.8
Reaction time mean minus median0.10.20.20.40.30.40.4-0.40.40.50.5
Reaction time mean minus median AUC0.00.10.10.30.30.30.3-0.30.30.30.3
Reaction time num false alarms0.10.10.20.40.30.40.4-0.40.40.10.1
Reaction time num false alarms AUC0.00.10.10.30.20.30.3-0.30.4-0.0-0.0
Reaction time trials correct on left0.50.91.11.11.01.01.0-1.11.00.80.8
Reaction time trials on left0.40.70.90.90.90.90.9-0.90.80.60.6
Reaction time mean0.10.20.30.40.50.50.5-0.40.40.30.3
Reaction time mean AUC0.20.40.50.60.70.60.7-0.60.60.50.5
Median of all reaction times0.10.10.30.40.50.40.4-0.30.40.20.2
Reaction time omissions1.82.73.0-1.6-1.6-1.6-1.61.6-1.6-1.7-1.7
Reaction time false alarm rate0.10.10.2-0.3-0.4-0.3-0.30.3-0.2-0.4-0.4
Reaction time premature initiation rate1.72.42.71.61.61.61.6-1.51.61.31.3
Reaction time premature initiations1.93.43.92.02.02.02.0-1.92.01.51.5
Std. dev. reaction times0.10.10.20.40.40.40.4-0.40.40.30.3
Reaction time trials completed0.40.70.90.90.90.90.9-0.90.80.60.6
Reaction time trials AUC0.30.60.80.90.80.80.8-0.90.80.60.6
Run reversals in cocaine runway, females3.23.23.6-1.9-1.7-1.8-1.81.8-1.7-1.8-1.8
Run reversals in cocaine runway, males2.12.12.71.41.61.41.4-1.41.41.41.4
Latency to leave start box in cocaine runway0.50.50.70.80.50.70.7-0.70.80.70.7
Latency to leave start box in cocaine runway, F1.41.61.81.31.21.21.2-1.31.31.21.2
Latency to leave start box in cocaine runway, M0.10.10.3-0.3-0.6-0.3-0.30.3-0.3-0.3-0.3
Std. dev. time between licks in bursts1.52.02.8-1.3-1.3-1.3-1.31.3-1.3-1.7-1.7
Total sessions with >9 infusions0.00.00.10.20.20.20.2-0.20.20.20.2
Short access day 1 total inactive lever presses0.10.20.2-0.4-0.5-0.4-0.40.4-0.4-0.4-0.4
Short access day 10 total inactive lever presses0.10.20.4-0.4-0.6-0.5-0.50.4-0.5-0.5-0.5
Short access day 1 total infusions0.00.10.10.20.20.30.3-0.20.30.30.3
Short access day 10 total infusions0.30.40.40.60.50.60.6-0.60.60.60.6
Short access total infusions0.00.00.10.20.10.20.2-0.20.20.20.2
Short access day 1 locomotion0.81.01.11.00.91.01.0-1.01.01.01.0
Short access day 10 total locomotion0.00.00.00.1-0.0-0.0-0.0-0.1-0.1-0.0-0.0
Short access total locomotion0.10.10.10.30.40.40.4-0.30.40.40.4
One hour access (0.3 mA shock)0.70.80.9-0.9-0.9-0.9-0.90.9-0.9-0.9-0.9
Compulsive drug intake0.50.70.8-0.8-0.7-0.8-0.80.8-0.9-0.8-0.8
One hour access (shock baseline)0.00.00.0-0.1-0.1-0.0-0.00.10.0-0.0-0.0
Social response proportion0.10.20.30.30.40.30.3-0.30.40.50.5
Social responses0.91.21.4-1.2-1.1-1.2-1.21.2-1.2-0.9-0.9
Social time0.30.40.6-0.7-0.7-0.7-0.70.8-0.6-0.5-0.5
Soleus weight1.23.43.92.01.91.91.9-1.91.91.61.6
Bone: stiffness0.71.21.51.11.11.11.1-0.91.11.21.2
Tibialis anterior weight8.328.228.75.45.35.35.3-5.35.35.35.3
Time to tail flick, vehicle, before self-admin1.11.11.4-1.0-1.2-1.0-1.01.1-1.1-1.0-1.0
Time to tail flick, vehicle, after self-admin1.41.92.01.41.41.41.4-1.31.41.41.4
Time to tail flick, test, before self-admin3.13.23.7-1.8-1.7-1.8-1.81.9-1.8-1.8-1.8
Time to tail flick, test, after self-admin2.32.42.5-1.6-1.5-1.6-1.61.4-1.6-1.6-1.6
Delta time to tail flick, vehicle, before/after SA0.30.30.50.50.60.50.5-0.70.60.50.5
Delta time to tail flick, test, before/after SA0.00.00.0-0.1-0.1-0.1-0.1-0.1-0.1-0.1-0.1
Tibia length1.13.13.6-1.9-1.8-1.8-1.81.9-1.8-1.5-1.5
Ambulatory time before self-admin0.20.30.40.60.50.60.6-0.50.60.60.6
Ambulatory time after self-admin5.36.26.32.52.52.52.5-2.52.52.52.5
Bone: tissue strength0.00.00.1-0.2-0.2-0.2-0.20.2-0.2-0.0-0.0
Total heroin consumption0.60.70.90.80.90.80.8-0.60.90.80.8
Bone: trabecular number2.13.53.8-1.9-2.0-1.9-1.91.9-1.9-1.8-1.8
Bone: trabecular spacing2.33.03.11.71.71.71.7-1.81.71.81.8
Bone: trabecular thickness1.11.41.5-1.2-1.2-1.2-1.21.2-1.2-1.2-1.2
Bone: trabecular tissue density1.31.92.01.41.41.41.4-1.41.41.41.4
Water consumed over 24 hours1.21.71.71.31.31.31.3-1.31.31.31.3
Number of responses in last shaping day0.60.60.70.70.80.80.8-0.70.80.80.8