Hub : Genes

Myo1e

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA isoform ratio NM_173101.2 0.53 0.11 2.2e-03 0.02 0.05 0.04 0.02 2.2e-02 9.9e-04 2.6e-03 4.5e-02
2 BLA isoform ratio XM_039080888.2 0.5 0.12 4.4e-03 0.02 0.04 0.03 0.01 2.3e-02 2.0e-03 9.9e-03 6.5e-02
3 Brain gene expression Myo1e 0.03 0.03 9.4e-04 0.02 0.03 0.02 0.02 4.4e-03 6.5e-04 2.9e-03 4.4e-03
4 Adipose alternative polyA NM_173101.2 0.04 0.03 2.2e-04 0.02 0.03 0.02 0.02 9.5e-04 5.7e-04 1.1e-03 1.1e-03
5 Adipose alternative polyA XM_039080888.2 0.04 0.03 1.8e-04 0.03 0.03 0.02 0.02 8.3e-04 5.1e-04 9.6e-04 9.3e-04
6 NAcc mRNA stability Myo1e 0.03 0.03 5.0e-05 0.03 0.03 0.03 0.03 4.0e-05 4.4e-05 3.8e-05 4.4e-05
7 Adipose gene expression Myo1e 0.43 0.18 0.0e+00 0.36 0.36 0.36 0.36 3.7e-41 2.6e-41 9.9e-42 7.7e-42
8 Eye intron excision ratio chr8_79886256_79888609 0.31 0.19 3.2e-03 0.11 0.11 0.07 0.12 1.0e-02 9.9e-03 3.3e-02 6.0e-03
9 Eye intron excision ratio chr8_79883828_79886122 0.3 0.19 4.0e-03 0.09 0.09 0.04 0.11 1.5e-02 1.5e-02 8.4e-02 9.2e-03
10 BLA gene expression Myo1e 0.18 0.15 5.6e-07 0.11 0.11 0.11 0.11 2.2e-06 1.5e-06 2.4e-06 1.4e-06
11 Adipose mRNA stability Myo1e 0.1 0.07 3.5e-12 0.09 0.09 0.09 0.09 2.6e-10 7.6e-10 2.7e-10 7.5e-10
12 Liver isoform ratio NM_173101.2 0.04 0.04 6.7e-05 0.03 0.03 0.03 0.03 1.6e-04 2.0e-04 1.8e-04 2.1e-04
13 Liver isoform ratio XM_039080888.2 0.05 0.05 6.7e-06 0.04 0.04 0.04 0.04 2.3e-05 2.9e-05 2.3e-05 2.6e-05
14 NAcc gene expression Myo1e 0.01 0.01 5.0e-03 0.01 0.01 0.01 0.01 2.6e-03 6.9e-03 2.1e-03 3.7e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.50.91.20.1-0.1-1.0-1.01.00.9-0.9-1.11.1-1.01.11.0-1.01.0
Area under the delay curve0.20.32.2-1.51.40.20.2-0.2-0.20.20.3-0.3-0.1-0.2-0.30.30.0
BMI with tail6.221.526.21.2-1.55.05.0-5.0-4.94.95.0-5.05.0-5.1-5.05.0-4.9
BMI without tail1.47.59.30.5-0.63.03.0-3.0-3.03.12.9-2.92.8-3.0-2.92.9-3.0
Body weight4.218.421.72.0-2.24.74.7-4.7-4.64.64.5-4.54.6-4.5-4.44.4-4.4
Weight adjusted by age1.95.76.91.2-1.32.62.6-2.6-2.62.62.4-2.42.5-2.6-2.42.4-2.6
Bone surface0.00.10.50.7-0.70.20.2-0.2-0.30.3-0.00.00.3-0.0-0.10.1-0.2
Bone volume0.00.10.40.6-0.6-0.1-0.10.10.00.0-0.20.20.10.20.1-0.10.1
Breakpoint value in progressive ratio session0.61.01.4-0.30.11.01.0-1.0-1.11.11.2-1.20.9-1.0-1.11.1-1.1
Number of licking bursts0.72.23.5-0.40.5-1.7-1.71.71.9-1.8-1.51.5-1.51.51.5-1.51.4
Context. condit. distance diff. score0.80.91.3-0.40.5-1.1-1.11.11.2-1.1-0.90.9-1.01.00.9-0.91.0
Locomotion velocity, session 11.51.78.02.8-2.80.70.7-0.7-0.50.50.7-0.71.3-0.6-0.90.9-1.0
Locomotion distance, session 10.60.71.71.3-1.2-0.8-0.80.80.9-0.9-0.70.7-0.40.90.7-0.70.6
Locomotion velocity, session 20.20.31.61.3-1.20.20.2-0.2-0.10.20.2-0.20.5-0.1-0.40.4-0.4
Locomotion distance, session 20.30.42.51.6-1.50.10.1-0.1-0.00.00.3-0.30.3-0.1-0.30.3-0.4
Locomotion velocity, session 30.40.42.41.6-1.5-0.4-0.40.40.4-0.4-0.40.40.10.50.2-0.20.3
Locomotion distance, session 32.02.33.50.4-0.3-1.7-1.71.71.8-1.9-1.61.6-1.31.71.4-1.41.5
Stereotopy head waving bouts, day 30.80.91.4-0.80.81.11.1-1.1-1.21.10.9-0.90.9-1.0-0.80.8-0.8
Stereotopy head waving duration, day 31.01.21.6-0.80.71.21.2-1.2-1.31.31.1-1.11.0-1.1-1.01.0-0.9
Locomotion velocity, session 71.82.02.61.1-1.0-1.6-1.61.61.6-1.5-1.41.4-1.21.61.4-1.41.3
Locomotion distance, session 71.51.92.90.7-0.6-1.6-1.61.61.7-1.6-1.21.2-1.41.31.3-1.31.3
Stereotopy head waving bouts, day 71.72.03.0-1.41.31.51.5-1.5-1.71.71.3-1.31.1-1.2-1.31.3-1.2
Stereotopy head waving duration, day 71.51.93.3-1.81.71.51.5-1.5-1.71.61.2-1.20.9-1.0-1.11.1-1.1
Locomotion velocity, session 81.01.28.22.9-2.80.10.1-0.10.2-0.20.3-0.30.7-0.2-0.40.4-0.5
Locomotion distance, session 80.81.11.71.0-0.9-1.2-1.21.21.3-1.3-0.90.9-0.91.10.9-0.91.0
Degree of sensitization distance0.10.10.4-0.60.6-0.3-0.30.30.1-0.0-0.10.1-0.60.10.3-0.30.2
Degree of sensitization stereotypy1.01.11.7-1.31.21.11.1-1.1-1.31.30.9-0.90.7-0.8-1.01.0-0.9
Conditioned locomotion0.10.10.3-0.50.5-0.4-0.40.40.4-0.4-0.30.3-0.50.30.3-0.30.1
Cocaine response after cond. corrected2.53.84.41.5-1.52.02.0-2.0-1.91.92.1-2.12.0-2.0-2.12.1-2.1
Cocaine response after cond. not corrected1.72.53.41.8-1.91.51.5-1.5-1.41.41.6-1.61.6-1.6-1.61.6-1.6
Cocaine response before conditioning0.81.01.60.2-0.2-1.1-1.11.11.0-1.0-1.11.1-1.01.01.2-1.21.2
Saline control response0.20.31.8-1.41.30.20.2-0.2-0.20.20.0-0.0-0.1-0.20.2-0.20.2
Bone: connectivity density0.91.51.9-0.20.2-1.3-1.31.31.2-1.2-1.41.4-1.41.41.3-1.31.3
Bone: cortical apparent density0.91.51.7-0.90.9-1.3-1.31.31.3-1.3-1.21.2-1.21.31.2-1.21.3
Bone: cortical area0.30.41.71.3-1.2-0.5-0.50.50.6-0.6-0.60.6-0.00.50.5-0.50.4
Bone: cortical porosity0.91.01.3-0.50.6-1.1-1.11.11.0-1.0-1.11.1-1.11.01.1-1.11.1
Bone: cortical porosity1.41.62.0-0.80.9-1.3-1.31.31.3-1.2-1.31.3-1.41.31.3-1.31.3
Bone: cortical thickness1.72.94.10.3-0.2-1.9-1.91.92.0-2.0-1.91.9-1.41.81.8-1.81.6
Bone: cortical thickness0.81.01.50.6-0.5-1.1-1.11.11.2-1.2-1.11.1-0.71.11.0-1.00.9
Bone: cortical tissue density0.91.41.5-0.90.9-1.2-1.21.21.2-1.2-1.21.2-1.21.21.2-1.21.2
Condit. Reinf. active minus inactive responses0.10.10.40.6-0.6-0.1-0.10.10.1-0.0-0.20.20.00.20.2-0.20.2
Condit. Reinf. active-inactive response ratio0.40.50.7-0.30.3-0.7-0.70.70.8-0.8-0.70.7-0.60.70.8-0.80.8
Condit. Reinf. active responses0.40.51.11.0-1.00.70.7-0.7-0.70.80.5-0.50.8-0.5-0.50.5-0.5
Condit. Reinf. inactive responses0.91.11.50.9-0.91.21.2-1.2-1.21.21.0-1.01.1-1.0-0.90.9-1.0
Incentive salience index mean0.20.31.91.4-1.3-0.1-0.10.10.1-0.2-0.30.30.30.30.3-0.30.2
Condit. Reinf. lever presses0.30.52.71.6-1.6-0.3-0.30.30.5-0.5-0.40.40.20.50.3-0.30.3
Condit. Reinf. active minus inactive responses2.33.65.92.4-2.41.91.9-1.9-1.81.81.6-1.62.3-1.7-1.51.5-1.8
Condit. Reinf. active-inactive response ratio0.50.81.20.5-0.51.11.1-1.1-1.11.00.8-0.81.1-0.9-0.80.8-0.9
Condit. Reinf. active responses1.82.58.42.9-2.81.31.4-1.4-1.31.31.0-1.01.9-1.1-1.01.0-1.2
Condit. Reinf. inactive responses0.81.28.22.9-2.7-0.2-0.20.20.2-0.2-0.30.30.50.30.2-0.20.2
Condit. Reinf. lever presses1.11.52.81.7-1.5-1.0-1.01.01.0-1.0-1.41.4-0.51.31.4-1.41.2
Condit. Reinf. lever reinforcers received1.41.97.92.8-2.71.11.1-1.1-1.01.00.7-0.71.6-0.8-0.70.7-0.9
Conditioned reinforcement - actives0.41.78.6-2.92.80.80.8-0.8-1.00.90.9-0.90.2-0.9-0.80.8-0.7
Conditioned reinforcement - inactives0.10.32.0-1.41.3-0.1-0.10.10.1-0.1-0.00.0-0.1-0.00.0-0.0-0.0
Conditioned locomotion0.81.28.1-2.82.7-0.1-0.10.1-0.10.1-0.10.1-0.6-0.10.1-0.10.3
Patch foraging indifference point 0 sec0.30.84.12.0-1.90.50.5-0.5-0.50.40.2-0.21.0-0.3-0.30.3-0.3
Patch foraging indifference point AUC0.20.63.82.0-1.9-0.1-0.10.10.2-0.20.0-0.00.50.1-0.00.0-0.2
Delay disc. indifference point, 0s delay0.40.52.1-1.41.4-0.4-0.40.40.4-0.5-0.40.4-0.60.40.5-0.50.5
Delay disc. indifference point, 16s delay0.50.74.9-2.22.1-0.1-0.10.10.1-0.10.2-0.2-0.4-0.1-0.00.00.2
Delay disc. indifference point, 2s delay0.50.53.6-1.91.80.10.1-0.1-0.10.10.1-0.1-0.2-0.1-0.20.2-0.0
Delay disc. indifference point, 24s delay0.10.20.7-0.80.8-0.3-0.40.40.4-0.4-0.20.2-0.50.30.3-0.30.7
Delay disc. indifference point, 4s delay0.30.32.0-1.41.4-0.0-0.00.00.00.0-0.10.1-0.50.10.2-0.20.3
Delay disc. indifference point, 8s delay0.10.20.5-0.70.70.30.3-0.3-0.40.40.4-0.40.1-0.3-0.50.5-0.2
Indifference point function ln k0.20.50.8-0.40.40.80.8-0.8-0.90.90.8-0.80.4-0.8-0.70.7-0.5
Indifference point function log k0.20.50.8-0.40.40.80.8-0.8-0.90.90.8-0.80.4-0.8-0.70.7-0.5
Patch foraging total patch changes 0 sec0.30.94.72.2-2.10.60.6-0.6-0.60.50.3-0.31.1-0.4-0.30.3-0.4
Patch foraging total patch changes 12 sec0.30.42.21.5-1.4-0.1-0.10.10.1-0.1-0.30.30.40.30.4-0.40.2
Patch foraging total patch changes 18 sec0.10.20.70.8-0.80.40.4-0.4-0.30.40.2-0.20.7-0.2-0.30.3-0.4
Patch foraging total patch changes 24 sec0.51.611.13.3-3.20.00.1-0.1-0.00.1-0.20.20.70.20.2-0.2-0.2
Patch foraging total patch changes 6 sec0.71.35.62.4-2.30.70.7-0.7-0.70.70.6-0.61.3-0.5-0.70.7-0.8
Patch foraging time to switch 0 sec0.72.68.5-2.92.9-1.3-1.31.31.2-1.2-1.21.2-1.81.21.1-1.11.3
Patch foraging water rate 0 sec0.93.54.92.2-2.21.91.9-1.9-1.81.81.7-1.72.1-1.8-1.61.6-1.7
Patch foraging water rate 12 sec1.56.212.33.5-3.52.32.3-2.3-2.22.22.1-2.12.9-2.1-2.12.1-2.4
Patch foraging water rate 18 sec0.30.72.71.6-1.60.70.7-0.7-0.80.80.5-0.50.8-0.5-0.40.4-0.5
Patch foraging water rate 24 sec0.50.72.71.6-1.60.60.6-0.6-0.50.50.5-0.51.1-0.4-0.60.6-0.7
Patch foraging water rate 6 sec1.21.72.01.2-1.11.41.4-1.4-1.41.41.3-1.31.4-1.4-1.21.2-1.2
Seeking ratio, delayed vs. immediate footshock0.60.81.91.4-1.40.80.8-0.8-0.60.70.8-0.81.0-0.8-0.80.8-1.0
Distance traveled before self-admin0.71.58.8-3.02.80.50.5-0.5-0.50.40.8-0.8-0.1-0.7-0.60.6-0.4
Distance traveled after self-admin0.81.41.8-0.30.31.31.3-1.3-1.31.21.3-1.31.0-1.4-1.31.3-1.2
Extensor digitorum longus weight7.228.733.71.9-2.25.85.8-5.8-5.75.75.7-5.75.4-5.7-5.75.7-5.8
Bone: elastic displacement0.40.50.7-0.80.70.70.7-0.7-0.70.70.7-0.70.5-0.7-0.70.7-0.7
Bone: elastic work0.00.00.20.4-0.40.00.0-0.00.1-0.0-0.00.00.10.1-0.10.1-0.1
Bone: endosteal estimation1.74.14.91.6-1.62.12.1-2.1-2.12.12.1-2.12.2-2.1-2.12.1-2.0
Bone: endosteal perimeter2.56.17.22.1-2.22.52.5-2.5-2.42.42.5-2.52.7-2.5-2.52.5-2.5
Epididymis fat weight0.00.10.8-0.90.90.20.1-0.1-0.20.2-0.10.10.1-0.1-0.10.1-0.0
Delta time in closed arm before/after self-admin1.31.31.7-0.30.3-1.3-1.31.31.3-1.2-1.31.3-1.11.21.1-1.11.1
Delta time in open arm before/after self-admin0.20.20.40.6-0.5-0.5-0.40.40.6-0.6-0.50.5-0.40.40.5-0.50.3
Diff in mean of infusions in LGA sessions0.71.21.9-0.1-0.01.21.2-1.2-1.41.41.2-1.21.0-1.1-1.11.1-1.0
Delay discount exponential model param0.30.42.01.4-1.4-0.4-0.30.30.3-0.4-0.40.40.00.40.4-0.40.1
Extinction: sum of active levers before priming0.20.30.50.3-0.30.70.7-0.7-0.70.70.7-0.70.4-0.6-0.50.5-0.6
Active lever presses in extinction session 60.60.60.9-0.40.40.80.8-0.8-0.90.90.8-0.80.6-0.8-1.01.0-0.8
Bone: final force0.61.06.52.6-2.50.30.3-0.3-0.10.10.2-0.20.9-0.2-0.30.3-0.5
Bone: final moment0.60.96.22.5-2.4-0.2-0.20.20.3-0.3-0.20.20.50.30.1-0.1-0.0
Food consumed during 24 hour testing period0.51.01.5-0.50.51.21.2-1.2-1.21.21.1-1.10.8-1.1-1.01.0-0.9
Glucose0.91.42.91.7-1.71.11.1-1.1-0.90.91.1-1.11.3-0.9-1.21.2-1.1
Heart weight1.52.32.9-1.51.41.61.6-1.6-1.71.71.6-1.61.1-1.7-1.51.5-1.2
Delay discount hyperbolic model param0.30.42.61.6-1.6-0.2-0.20.20.2-0.3-0.30.30.20.20.2-0.2-0.0
Intermittent access intake day 1-15 change0.21.34.6-2.12.1-0.7-0.80.80.6-0.6-0.90.9-1.41.00.9-0.90.8
Intermittent access intake escalation0.20.82.2-1.51.5-0.7-0.70.70.5-0.6-0.90.9-1.20.90.8-0.80.6
Intermittent access intake escalation 20.30.52.9-1.71.60.20.2-0.2-0.30.20.2-0.2-0.5-0.1-0.20.2-0.3
Intermitt. access day 1 inactive lever presses0.33.74.6-0.91.0-2.0-2.02.01.9-2.0-2.12.1-1.92.12.1-2.12.1
Intermitt. access day 15 inactive lever presses0.20.94.6-2.12.00.60.6-0.6-0.70.70.5-0.5-0.1-0.6-0.40.4-0.4
Intermitt. access escalation Index0.10.40.9-0.0-0.00.70.7-0.7-0.60.70.9-0.90.9-0.8-0.50.5-0.5
Intermittent access day 1 total infusions0.20.60.8-0.60.6-0.9-0.90.90.9-0.9-0.80.8-0.80.60.7-0.70.8
Intermittent access day 15 total infusions0.71.62.1-1.41.4-1.2-1.21.21.1-1.1-1.41.4-1.51.21.3-1.31.1
Intermittent access terminal intake (last 3 days)0.40.82.7-1.71.6-0.6-0.60.60.5-0.5-0.70.7-1.00.60.6-0.60.5
Intermittent access total infusions0.30.31.0-1.01.0-0.4-0.40.40.4-0.3-0.50.5-0.60.40.4-0.40.4
Intermittent access day 1 locomotion1.42.53.2-1.41.4-1.6-1.61.61.5-1.5-1.81.8-1.61.51.6-1.61.7
Intermittent access day 15 total locomotion0.62.34.1-1.81.9-1.3-1.31.31.2-1.2-1.61.6-2.01.41.4-1.41.6
Intermittent access total locomotion0.30.42.4-1.51.50.10.1-0.1-0.30.3-0.20.2-0.5-0.00.0-0.00.3
Intermittent access standard deviation0.10.41.2-1.11.1-0.4-0.40.40.3-0.4-0.60.6-0.90.60.3-0.30.4
Left kidney weight1.07.910.5-0.60.43.13.1-3.1-3.23.23.0-3.02.7-3.0-3.03.0-3.0
Right kidney weight1.611.013.60.2-0.53.63.6-3.6-3.63.73.7-3.73.3-3.6-3.53.5-3.4
Cocaine induced anxiety0.10.21.4-1.21.1-0.2-0.20.20.1-0.0-0.20.2-0.30.10.1-0.10.5
Post-drug Anxiety2.12.33.0-1.31.3-1.6-1.61.61.5-1.5-1.51.5-1.71.61.5-1.51.7
Baseline Anxiety0.61.11.60.5-0.4-1.1-1.11.11.2-1.2-1.11.1-0.91.21.0-1.00.9
Tail length0.00.00.00.0-0.00.10.1-0.1-0.20.1-0.10.1-0.10.10.1-0.1-0.1
Length with tail0.52.33.01.7-1.71.61.6-1.6-1.61.51.4-1.41.6-1.3-1.31.3-1.5
Length without tail2.010.513.42.9-3.03.43.4-3.4-3.23.23.3-3.33.7-3.2-3.23.2-3.1
Times rat made contact with spout1.21.48.3-2.92.8-0.5-0.50.50.5-0.4-0.30.3-1.30.30.4-0.40.6
Lifetime Intake0.10.10.2-0.40.4-0.4-0.40.40.4-0.4-0.40.4-0.30.30.2-0.20.1
Liver weight, left3.25.56.52.5-2.62.42.4-2.4-2.32.32.2-2.22.5-2.3-2.22.2-2.3
Liver weight, right1.42.48.22.9-2.81.11.1-1.1-0.90.91.3-1.31.7-1.1-1.21.2-1.3
Locomotor activity5.78.911.30.7-0.83.33.3-3.3-3.43.33.3-3.32.9-3.2-3.13.1-3.0
Locomotor testing distance2.56.08.0-0.1-0.12.82.7-2.7-2.82.82.7-2.72.2-2.6-2.62.6-2.4
Locomotor testing rearing0.93.34.60.6-0.72.02.0-2.0-2.12.11.9-1.91.8-1.8-1.91.9-1.8
Locomotion in novel chamber0.30.30.8-0.20.3-0.5-0.50.50.3-0.3-0.80.8-0.40.50.9-0.90.8
Locomotion in novel chamber post-restriction0.30.81.3-1.21.1-0.8-0.80.80.8-0.8-0.80.8-1.00.80.8-0.81.0
Fecal boli incidents, locomotor time 10.10.21.0-1.01.0-0.0-0.10.10.1-0.1-0.20.2-0.3-0.00.2-0.20.3
Change in fecal boli incidents, locomotor task0.20.21.01.0-1.0-0.00.0-0.00.1-0.00.3-0.30.20.0-0.10.1-0.3
Time >=10cm from walls, locomotor time 10.10.20.3-0.50.50.40.4-0.4-0.40.40.4-0.40.2-0.5-0.50.5-0.3
Bouts of movement, locomotor time 10.00.00.10.1-0.00.10.2-0.2-0.30.3-0.20.20.2-0.20.1-0.1-0.4
Total resting periods, locomotor time 10.00.00.2-0.10.10.20.2-0.2-0.30.3-0.10.10.2-0.20.1-0.1-0.4
Rest time, locomotor task time 10.00.00.10.3-0.2-0.1-0.10.10.1-0.1-0.10.1-0.10.20.1-0.1-0.3
Distance moved, locomotor task time 10.00.10.3-0.20.2-0.3-0.30.30.3-0.3-0.20.2-0.20.10.2-0.20.5
Vertical activity count, locomotor time 10.00.31.3-1.21.1-0.3-0.30.30.2-0.2-0.20.2-0.40.00.2-0.20.7
Time >=10cm from walls, locomotor time 20.00.10.30.5-0.5-0.1-0.10.10.3-0.3-0.10.10.30.00.0-0.00.2
Bouts of movement, locomotor time 20.51.82.5-0.70.61.51.4-1.4-1.51.41.5-1.51.0-1.6-1.41.4-1.5
Total resting periods, locomotor time 20.52.02.8-0.60.61.51.5-1.5-1.61.51.5-1.51.0-1.6-1.51.5-1.7
Rest time, locomotor task time 20.10.20.50.1-0.0-0.5-0.50.50.4-0.5-0.60.6-0.50.70.5-0.50.3
Distance moved, locomotor task time 20.00.10.10.3-0.3-0.2-0.20.20.4-0.4-0.20.2-0.1-0.00.1-0.10.3
Vertical activity count, locomotor time 20.30.83.9-2.01.9-0.5-0.50.50.5-0.4-0.40.4-0.90.20.4-0.40.9
Light reinforcement 11.14.95.92.2-2.22.22.2-2.2-2.12.12.3-2.32.4-2.4-2.12.1-2.1
Light reinforcement 20.30.62.11.5-1.4-0.6-0.60.60.6-0.7-0.60.6-0.20.60.5-0.50.5
Bone: marrow area1.74.14.81.6-1.62.12.1-2.1-2.02.12.1-2.12.2-2.1-2.02.0-2.0
Bone: maximum diameter1.63.35.12.3-2.31.71.7-1.7-1.51.61.7-1.72.0-1.7-1.71.7-1.8
Bone: maximum force0.20.52.51.6-1.50.40.4-0.4-0.20.20.3-0.30.7-0.3-0.40.4-0.5
Bone: maximum moment0.20.32.21.5-1.4-0.0-0.00.00.1-0.1-0.10.10.40.1-0.00.0-0.1
Mean time between licks in bursts0.10.51.6-1.31.2-0.6-0.60.60.6-0.6-0.30.3-0.80.40.6-0.60.7
Mean num. licks in bursts0.51.32.0-1.11.11.31.3-1.3-1.41.41.1-1.10.6-1.1-1.11.1-0.9
Cd content in liver1.21.31.6-1.11.1-1.2-1.21.21.1-1.2-1.11.1-1.31.11.1-1.11.2
Co content in liver1.21.42.0-1.31.3-1.2-1.21.21.3-1.2-1.01.0-1.41.11.1-1.11.1
Cu content in liver0.10.10.80.9-0.8-0.2-0.20.20.3-0.3-0.10.1-0.10.0-0.00.0-0.0
Fe content in liver0.20.30.91.0-0.90.50.5-0.5-0.40.40.3-0.30.5-0.5-0.30.3-0.3
K content in liver1.41.41.80.8-0.81.31.3-1.3-1.31.31.1-1.11.3-1.2-1.21.2-1.3
Mg content in liver1.31.41.80.6-0.71.31.3-1.3-1.31.31.2-1.21.3-1.2-1.21.2-1.3
Mn content in liver0.00.00.0-0.10.1-0.2-0.20.20.2-0.1-0.10.1-0.1-0.00.1-0.10.2
Na content in liver6.87.69.22.9-2.92.82.8-2.8-2.62.72.7-2.73.0-2.8-2.72.7-2.8
Rb content in liver0.50.60.8-0.20.20.80.8-0.8-0.90.90.8-0.80.6-0.8-0.80.8-0.8
Se content in liver0.10.10.2-0.40.4-0.1-0.10.10.1-0.1-0.30.3-0.20.10.3-0.30.2
Sr content in liver0.00.00.1-0.20.2-0.2-0.20.20.2-0.2-0.20.2-0.10.20.2-0.20.2
Zn content in liver0.00.00.00.1-0.00.10.1-0.1-0.10.10.0-0.00.2-0.1-0.10.1-0.2
Bone: minimum diameter0.10.10.30.6-0.5-0.2-0.20.20.2-0.2-0.40.4-0.00.30.4-0.40.4
Time in familiar zone, hab. session 10.20.21.41.2-1.1-0.2-0.20.20.2-0.2-0.30.3-0.00.10.2-0.20.0
Time in novel zone, hab. session 10.20.21.1-1.11.0-0.1-0.10.10.2-0.20.0-0.0-0.30.10.0-0.00.1
Total zone transitions, hab. session 10.71.01.30.8-0.7-1.1-1.11.11.1-1.1-1.11.1-0.81.01.1-1.11.0
Total locomotion distance, hab. session 10.10.20.40.6-0.5-0.4-0.40.40.5-0.5-0.40.4-0.20.20.4-0.40.5
Locomotion velocity, hab. session 10.00.00.20.4-0.4-0.1-0.10.10.2-0.1-0.10.10.00.00.2-0.20.2
Time in familiar zone, hab. session 20.10.10.50.7-0.7-0.3-0.30.30.4-0.4-0.10.1-0.20.20.1-0.10.0
Time in novel zone, hab. session 20.10.10.5-0.70.7-0.0-0.00.0-0.10.1-0.20.2-0.20.30.2-0.20.3
Total zone transitions, hab. session 20.40.52.61.6-1.60.30.3-0.3-0.00.10.5-0.50.7-0.5-0.50.5-0.5
Total locomotion distance, hab. session 20.60.81.00.8-0.80.80.8-0.8-0.70.71.0-1.00.9-1.0-1.01.0-0.9
Locomotion velocity, hab. session 20.30.40.50.6-0.70.50.5-0.5-0.40.40.7-0.70.7-0.7-0.70.7-0.6
Novel to familiar place preference ratio0.91.22.00.1-0.11.21.2-1.2-1.41.41.0-1.01.1-0.9-1.11.1-1.1
Novelty place preference0.91.11.90.3-0.41.21.2-1.2-1.41.41.0-1.01.1-0.8-1.11.1-1.2
Time in novel zone, NPP test1.11.42.30.4-0.41.31.3-1.3-1.51.51.1-1.11.2-1.0-1.21.2-1.3
Total zone transitions, NPP test0.10.21.01.0-0.90.40.4-0.4-0.30.30.2-0.20.5-0.2-0.20.2-0.3
Total locomotion distance, NPP test0.50.60.90.9-0.90.80.8-0.8-0.80.80.7-0.70.9-0.7-0.70.7-0.7
Locomotion velocity, NPP test0.20.20.50.7-0.70.50.5-0.5-0.50.40.4-0.40.6-0.4-0.30.3-0.3
Intraocular pressure0.00.10.20.0-0.00.00.0-0.00.1-0.00.4-0.4-0.1-0.4-0.30.3-0.3
Delta distance traveled before/after self-admin1.51.66.82.6-2.50.90.9-0.9-0.90.90.7-0.71.3-0.7-0.80.8-1.0
Delta ambulatory time before/after self-admin0.50.84.52.1-2.00.50.5-0.5-0.50.50.3-0.30.9-0.3-0.30.3-0.4
Parametrial fat weight0.92.24.20.4-0.3-1.8-1.81.82.1-2.0-1.41.4-1.51.41.3-1.31.1
Pavlov. Cond. lever latency0.10.10.3-0.40.4-0.3-0.30.30.3-0.2-0.10.1-0.50.10.1-0.10.3
Pavlov. Cond. magazine entry latency0.81.11.50.9-0.9-1.1-1.11.11.1-1.2-1.11.1-0.61.21.0-1.01.0
Pavlov. Cond. change in total contacts0.20.21.3-1.11.10.10.1-0.1-0.10.1-0.20.2-0.10.00.2-0.20.1
Pavlov. Cond. index score0.60.71.10.3-0.2-0.9-0.90.91.0-1.0-1.01.0-0.51.01.0-1.00.8
Pavlov. Cond. latency score0.30.40.60.5-0.4-0.5-0.50.50.6-0.7-0.80.8-0.20.80.7-0.70.5
Pavlov. Cond. lever contacts0.00.00.20.4-0.4-0.1-0.10.10.2-0.2-0.20.20.20.20.1-0.10.0
Pavlov. Cond. magazine entry number1.01.21.7-0.30.21.21.2-1.2-1.31.31.2-1.20.8-1.3-1.21.2-1.1
Pavlov. Cond. intertrial magazine entries0.20.21.11.0-1.00.30.3-0.3-0.30.30.4-0.40.4-0.2-0.30.3-0.3
Pavlov. Cond. lever-magazine prob. diff.0.40.40.70.5-0.4-0.7-0.70.70.7-0.8-0.80.8-0.30.80.7-0.70.6
Pavlov. Cond. response bias0.40.50.70.3-0.3-0.7-0.70.70.8-0.9-0.80.8-0.40.90.7-0.70.7
Pavlov. Cond. lever latency0.81.13.5-1.91.70.80.8-0.8-0.70.81.1-1.10.3-1.0-1.11.1-0.9
Pavlov. Cond. magazine entry latency3.04.25.4-0.80.9-2.1-2.12.12.1-2.1-2.32.3-2.12.12.3-2.32.2
Pavlov. Cond. change in total contacts0.30.81.30.8-0.6-0.8-0.80.80.8-0.8-1.01.0-0.61.01.2-1.21.1
Pavlov. Cond. index score1.01.62.20.8-0.7-1.3-1.31.31.2-1.3-1.51.5-1.01.41.5-1.51.3
Pavlov. Cond. latency score0.71.11.50.8-0.6-1.0-1.01.01.0-1.0-1.21.2-0.81.11.2-1.21.1
Pavlov. Cond. lever contacts0.71.03.11.8-1.6-0.7-0.70.70.7-0.7-1.01.0-0.31.01.0-1.00.8
Pavlov. Cond. magazine entry number3.44.45.50.3-0.52.22.2-2.2-2.22.22.3-2.32.1-2.2-2.32.3-2.3
Pavlov. Cond. intertrial magazine entries0.61.41.71.1-1.11.11.1-1.1-1.11.21.3-1.31.3-1.2-1.21.2-1.1
Pavlov. Cond. lever-magazine prob. diff.1.21.82.40.8-0.6-1.4-1.41.41.3-1.4-1.61.6-1.11.51.5-1.51.4
Pavlov. Cond. response bias1.72.43.30.9-0.8-1.5-1.51.51.5-1.5-1.81.8-1.21.71.8-1.81.6
Time in closed arm before self-admin0.50.96.2-2.52.40.10.1-0.1-0.20.20.0-0.0-0.6-0.10.0-0.00.2
Time in closed arm after self-admin0.91.14.3-2.12.0-0.7-0.70.70.6-0.6-0.70.7-1.00.70.8-0.80.8
Time in open arm before self-admin0.60.71.10.7-0.70.70.7-0.7-0.80.81.0-1.01.0-0.8-1.01.0-0.8
Time in open arm after self-admin0.40.41.41.2-1.20.50.5-0.5-0.40.40.5-0.50.6-0.5-0.50.5-0.6
Bone: periosteal estimation0.92.04.12.0-2.01.31.3-1.3-1.21.21.2-1.21.7-1.3-1.31.3-1.3
Bone: periosteal perimeter1.42.84.22.0-2.01.61.6-1.6-1.51.51.5-1.51.9-1.6-1.61.6-1.6
Bone: post-yield work0.00.10.1-0.30.30.30.3-0.3-0.30.30.3-0.30.2-0.4-0.30.3-0.2
Progressive ratio test 1 active lever presses0.00.10.2-0.50.5-0.3-0.30.30.3-0.3-0.20.2-0.10.20.1-0.10.2
Progressive ratio test 1 breakpoint0.10.10.2-0.40.4-0.4-0.40.40.4-0.3-0.30.3-0.20.30.2-0.20.2
Progressive ratio test 1 inactive lever presses1.12.94.1-0.30.4-2.0-2.02.02.0-2.0-1.91.9-1.51.91.7-1.71.6
Progressive ratio test 2 active lever presses0.30.40.8-0.90.80.50.5-0.5-0.60.60.5-0.50.4-0.5-0.60.6-0.6
Progressive ratio test 2 breakpoint0.20.30.7-0.90.80.50.5-0.5-0.50.60.4-0.40.3-0.5-0.60.6-0.6
Progressive ratio test 2 inactive lever presses0.10.42.2-1.51.4-0.3-0.30.30.3-0.3-0.40.4-0.40.40.3-0.30.4
Incentive Sensitization - Responses0.20.61.4-1.21.10.70.7-0.7-0.80.80.6-0.60.2-0.7-0.70.7-0.6
Incentive Sensitization - Breakpoint0.20.51.8-1.31.30.60.6-0.6-0.60.60.4-0.40.1-0.6-0.60.6-0.5
Sum of active levers in priming session hrs 5-60.20.20.3-0.30.30.40.4-0.4-0.50.50.5-0.50.1-0.4-0.40.4-0.4
Progressive ratio0.61.910.1-3.23.1-0.7-0.70.70.6-0.8-0.80.8-1.10.50.6-0.60.9
Food seeking constrained by brief footshock0.20.20.40.6-0.60.50.5-0.5-0.40.40.4-0.40.5-0.7-0.50.5-0.4
Seeking ratio, punishment vs. effort2.45.417.14.1-4.11.91.9-1.9-1.81.81.9-1.92.4-1.8-1.71.7-1.9
Retroperitoneal fat weight0.10.61.51.2-1.1-0.7-0.70.70.9-0.9-0.70.7-0.40.60.7-0.70.6
Reaction time number correct0.62.23.00.2-0.21.51.5-1.5-1.51.61.7-1.71.3-1.6-1.71.7-1.6
Reaction time mean minus median0.10.51.91.4-1.3-0.3-0.30.30.3-0.4-0.60.60.30.70.6-0.60.3
Reaction time mean minus median AUC0.21.11.81.3-1.3-0.9-0.90.91.0-1.0-1.11.1-0.31.21.1-1.10.7
Reaction time num false alarms0.50.81.30.7-0.6-1.0-1.01.01.2-1.2-0.80.8-0.61.00.9-0.90.8
Reaction time num false alarms AUC0.20.51.11.0-1.0-0.7-0.70.70.8-0.9-0.50.5-0.20.70.6-0.60.5
Reaction time trials correct on left0.62.23.00.2-0.21.51.5-1.5-1.51.61.7-1.71.3-1.6-1.71.7-1.6
Reaction time trials on left0.72.33.20.3-0.41.61.6-1.6-1.61.61.7-1.71.4-1.7-1.81.8-1.7
Reaction time mean1.63.54.70.6-0.5-2.0-2.02.02.0-2.0-2.12.1-1.62.12.2-2.21.8
Reaction time mean AUC1.02.53.20.6-0.5-1.7-1.71.71.7-1.7-1.81.8-1.31.71.8-1.81.5
Median of all reaction times3.75.77.20.10.0-2.6-2.62.62.6-2.6-2.62.6-2.32.62.7-2.72.4
Reaction time omissions0.20.30.70.8-0.90.40.4-0.4-0.30.30.4-0.40.6-0.3-0.40.4-0.6
Reaction time false alarm rate1.42.02.90.7-0.6-1.5-1.51.51.7-1.7-1.41.4-1.01.51.5-1.51.4
Reaction time premature initiation rate1.42.22.71.3-1.41.51.5-1.5-1.41.31.5-1.51.6-1.5-1.51.5-1.6
Reaction time premature initiations1.23.74.71.3-1.41.91.9-1.9-1.81.82.1-2.12.0-2.0-2.12.1-2.2
Std. dev. reaction times0.41.42.00.8-0.7-1.2-1.21.21.2-1.2-1.41.4-0.71.41.4-1.40.9
Reaction time trials completed0.72.33.20.3-0.41.61.6-1.6-1.61.61.7-1.71.4-1.7-1.81.8-1.7
Reaction time trials AUC0.62.02.80.2-0.21.51.5-1.5-1.41.51.6-1.61.2-1.5-1.71.7-1.6
Run reversals in cocaine runway, females0.00.00.1-0.0-0.0-0.2-0.20.20.1-0.1-0.00.0-0.4-0.1-0.10.10.0
Run reversals in cocaine runway, males0.20.31.81.3-1.30.10.1-0.10.0-0.00.1-0.10.3-0.2-0.10.1-0.1
Latency to leave start box in cocaine runway2.23.04.1-0.50.41.91.9-1.9-2.02.02.0-2.01.6-1.8-1.91.9-1.5
Latency to leave start box in cocaine runway, F0.70.81.3-0.30.21.11.1-1.1-1.11.11.0-1.01.0-0.9-0.90.9-0.6
Latency to leave start box in cocaine runway, M5.85.57.1-0.50.32.52.5-2.5-2.72.62.6-2.62.1-2.5-2.72.7-2.5
Std. dev. time between licks in bursts0.50.94.32.1-2.00.60.6-0.6-0.50.50.5-0.51.1-0.4-0.40.4-0.5
Total sessions with >9 infusions0.20.30.50.5-0.5-0.6-0.60.60.7-0.7-0.50.50.10.50.4-0.40.1
Short access day 1 total inactive lever presses0.40.81.1-1.11.1-0.9-0.90.91.0-1.0-0.80.8-0.60.60.8-0.80.8
Short access day 10 total inactive lever presses0.21.63.5-1.91.9-1.0-1.01.00.9-0.9-1.21.2-1.41.11.2-1.21.3
Short access day 1 total infusions0.10.31.6-1.31.2-0.3-0.30.30.4-0.4-0.20.2-0.20.2-0.00.0-0.1
Short access day 10 total infusions0.71.21.7-0.40.4-1.3-1.31.31.3-1.3-1.21.2-0.91.11.0-1.00.9
Short access total infusions0.30.50.9-0.20.2-0.9-0.90.90.9-0.9-0.70.7-0.40.70.6-0.60.5
Short access day 1 locomotion0.00.10.2-0.40.4-0.3-0.30.30.4-0.3-0.00.00.10.0-0.20.2-0.1
Short access day 10 total locomotion0.20.61.00.4-0.3-0.8-0.80.80.8-0.8-1.01.0-0.40.90.9-0.91.0
Short access total locomotion0.30.40.6-0.20.2-0.8-0.80.80.8-0.8-0.70.7-0.30.70.7-0.70.7
One hour access (0.3 mA shock)0.81.01.6-0.40.31.01.0-1.0-1.01.01.0-1.00.6-1.1-1.21.2-1.3
Compulsive drug intake1.01.52.21.4-1.51.11.1-1.1-1.01.01.3-1.31.3-1.3-1.21.2-1.2
One hour access (shock baseline)0.10.31.4-1.21.2-0.3-0.30.30.3-0.3-0.30.3-0.70.30.1-0.10.1
Social response proportion0.30.41.8-1.31.3-0.2-0.20.20.1-0.2-0.40.4-0.40.20.6-0.60.7
Social responses0.10.21.01.0-0.90.10.1-0.1-0.20.0-0.20.20.30.10.3-0.30.3
Social time0.10.21.1-1.01.00.30.3-0.3-0.30.20.0-0.0-0.1-0.1-0.10.1-0.1
Soleus weight14.843.750.13.2-3.57.17.1-7.1-7.07.07.0-7.06.8-6.9-7.07.0-7.1
Bone: stiffness0.71.23.21.8-1.81.01.0-1.0-0.90.90.8-0.81.3-0.8-0.80.8-0.9
Tibialis anterior weight12.141.848.23.4-3.76.96.9-6.9-6.76.76.8-6.86.8-6.8-6.96.9-6.9
Time to tail flick, vehicle, before self-admin0.30.40.60.5-0.4-0.6-0.60.60.6-0.6-0.80.8-0.40.70.8-0.80.6
Time to tail flick, vehicle, after self-admin1.53.017.7-4.24.1-0.7-0.70.70.5-0.5-0.50.5-1.60.60.7-0.71.0
Time to tail flick, test, before self-admin1.82.12.7-0.00.1-1.6-1.61.61.7-1.6-1.61.6-1.31.51.6-1.61.4
Time to tail flick, test, after self-admin3.63.818.8-4.34.2-1.2-1.21.21.0-1.0-1.01.0-1.91.01.0-1.01.5
Delta time to tail flick, vehicle, before/after SA1.61.810.5-3.23.1-0.6-0.60.60.5-0.5-0.40.4-1.20.40.5-0.50.7
Delta time to tail flick, test, before/after SA0.60.73.0-1.71.60.60.6-0.6-0.70.60.6-0.60.0-0.6-0.70.7-0.3
Tibia length0.10.31.0-1.01.0-0.3-0.30.30.2-0.2-0.40.4-0.50.40.5-0.50.6
Ambulatory time before self-admin0.20.53.3-1.81.70.10.1-0.1-0.0-0.00.3-0.3-0.2-0.3-0.20.2-0.1
Ambulatory time after self-admin0.30.50.60.3-0.30.70.7-0.7-0.70.70.8-0.80.7-0.7-0.80.8-0.7
Bone: tissue strength1.21.21.6-0.40.5-1.2-1.21.21.2-1.1-1.21.2-1.21.31.2-1.21.1
Total heroin consumption1.92.22.8-1.00.91.61.6-1.6-1.71.61.7-1.71.2-1.4-1.61.6-1.5
Bone: trabecular number1.22.32.90.10.1-1.6-1.61.61.6-1.5-1.71.7-1.61.71.6-1.61.6
Bone: trabecular spacing0.10.10.2-0.50.50.30.3-0.3-0.30.30.3-0.30.3-0.3-0.20.2-0.3
Bone: trabecular thickness0.50.61.0-0.40.4-0.9-0.90.91.0-0.9-0.80.8-1.00.70.7-0.70.7
Bone: trabecular tissue density3.45.97.12.3-2.42.42.4-2.4-2.32.32.5-2.52.7-2.3-2.52.5-2.6
Water consumed over 24 hours0.20.41.0-1.01.0-0.5-0.50.50.5-0.5-0.50.5-0.70.40.5-0.50.5
Number of responses in last shaping day0.60.85.5-2.32.30.20.1-0.1-0.40.40.0-0.0-0.3-0.1-0.10.1-0.0