Hub : Genes

Cfl1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 RMTg mRNA stability Cfl1 0.18 0.1 5.1e-04 0.02 0.02 -0 0 9.7e-02 1.2e-01 3.9e-01 3.2e-01
2 NAcc mRNA stability Cfl1 0.44 0.1 0.0e+00 0.58 0.6 0.61 0.61 9.8e-83 3.9e-88 5.6e-89 5.9e-90
3 pVTA mRNA stability Cfl1 0.52 0.12 0.0e+00 0.4 0.42 0.41 0.42 1.2e-18 1.2e-19 2.5e-19 1.1e-19
4 PL mRNA stability Cfl1 0.51 0.09 0.0e+00 0.62 0.63 0.63 0.63 4.6e-86 6.2e-90 3.5e-90 3.3e-90
5 Brain mRNA stability Cfl1 0.6 0.04 0.0e+00 0.69 0.65 0.69 0.68 1.5e-88 9.3e-80 3.6e-89 3.0e-86
6 Adipose mRNA stability Cfl1 0.25 0.1 2.4e-13 0.08 0.09 0.09 0.09 2.0e-09 1.5e-10 1.7e-10 3.9e-10
7 BLA mRNA stability Cfl1 0.66 0.1 0.0e+00 0.62 0.64 0.65 0.66 3.8e-42 3.5e-44 1.7e-44 1.5e-45
8 IL mRNA stability Cfl1 0.67 0.1 0.0e+00 0.43 0.46 0.48 0.48 1.3e-11 1.7e-12 2.7e-13 3.4e-13
9 LHb mRNA stability Cfl1 0.7 0.1 0.0e+00 0.51 0.51 0.54 0.52 3.9e-14 5.2e-14 4.1e-15 2.1e-14
10 Liver mRNA stability Cfl1 0.3 0.11 0.0e+00 0.18 0.2 0.2 0.17 2.4e-19 3.0e-21 2.0e-21 1.3e-18
11 OFC mRNA stability Cfl1 0.62 0.11 0.0e+00 0.58 0.47 0.58 0.59 1.5e-16 9.5e-13 9.9e-17 3.1e-17
12 Adipose gene expression Cfl1 0.07 0.04 5.9e-05 0.02 0.02 0.01 0.02 3.0e-03 2.2e-03 7.0e-03 6.2e-03
13 NAcc gene expression Cfl1 0.06 0.04 2.3e-04 0.01 0.01 0.01 0.01 5.1e-02 7.2e-03 3.9e-02 4.9e-02
14 Brain gene expression Cfl1 0.04 0.03 6.8e-04 0.05 0.03 0.05 0.05 3.6e-05 7.5e-04 8.4e-06 2.3e-05
15 Liver gene expression Cfl1 0.04 0.03 7.3e-03 0.01 0 0 0.01 1.7e-02 1.2e-01 7.4e-02 5.9e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.40.74.1-0.80.70.60.6-0.40.20.6-0.7-0.9-0.10.8-0.4-2.00.81.0
Area under the delay curve0.10.20.70.3-0.2-0.3-0.30.3-0.6-0.30.20.20.6-0.40.2-0.40.20.8
BMI with tail2.37.625.1-3.13.02.72.6-2.22.02.9-2.9-3.2-1.82.8-2.2-5.01.71.2
BMI without tail1.02.05.9-1.41.61.51.3-1.30.91.6-1.6-1.7-0.91.3-1.3-2.40.60.4
Body weight3.514.819.0-4.44.34.24.1-3.93.94.2-4.3-4.3-3.74.3-3.8-4.0-1.1-1.6
Weight adjusted by age2.32.63.5-1.61.91.71.8-1.61.91.6-1.7-1.7-1.71.7-1.6-1.2-1.1-1.2
Bone surface3.66.412.2-2.82.72.82.6-2.52.42.7-2.8-2.9-2.32.8-2.1-3.5-0.5-0.4
Bone volume1.32.27.7-1.61.51.51.4-1.31.21.4-1.5-1.7-1.11.6-0.9-2.80.30.6
Breakpoint value in progressive ratio session3.43.74.7-2.12.02.12.2-2.02.22.0-2.0-2.1-2.02.1-1.8-1.8-1.3-1.0
Number of licking bursts0.30.40.5-0.70.60.60.7-0.70.70.6-0.6-0.6-0.60.7-0.5-0.7-0.3-0.1
Context. condit. distance diff. score2.12.63.21.7-1.8-1.7-1.81.7-1.7-1.61.71.71.7-1.71.51.11.31.1
Locomotion velocity, session 10.10.10.50.10.10.10.0-0.20.10.1-0.1-0.0-0.2-0.0-0.40.6-0.3-0.7
Locomotion distance, session 10.40.51.5-0.60.80.70.6-0.50.40.7-0.8-0.9-0.30.8-0.8-1.20.40.2
Locomotion velocity, session 22.63.04.0-1.82.01.91.9-1.81.81.9-2.0-2.0-1.62.0-1.8-1.9-0.6-0.7
Locomotion distance, session 20.60.81.5-0.91.10.91.0-0.80.70.9-1.0-1.2-0.51.1-1.0-1.20.0-0.0
Locomotion velocity, session 30.30.42.40.3-0.4-0.5-0.50.7-0.5-0.40.40.30.7-0.20.4-0.41.51.0
Locomotion distance, session 30.00.00.10.1-0.2-0.2-0.20.2-0.2-0.20.20.20.2-0.10.10.10.30.2
Stereotopy head waving bouts, day 30.91.13.81.0-0.9-1.0-1.11.1-1.2-0.80.80.81.1-1.00.80.22.00.9
Stereotopy head waving duration, day 31.01.22.21.2-1.1-1.1-1.31.1-1.3-1.01.01.01.1-1.21.00.41.50.8
Locomotion velocity, session 71.01.14.10.5-0.6-0.8-0.81.1-0.9-0.70.70.51.2-0.50.9-0.92.01.9
Locomotion distance, session 70.20.21.00.0-0.1-0.3-0.20.6-0.4-0.20.30.10.6-0.10.1-0.41.00.8
Stereotopy head waving bouts, day 70.30.31.00.4-0.5-0.5-0.50.4-0.5-0.50.40.40.5-0.50.7-0.50.91.0
Stereotopy head waving duration, day 70.81.03.1-1.11.01.01.0-1.00.81.0-1.1-1.1-0.81.0-0.7-1.7-0.10.3
Locomotion velocity, session 81.11.32.3-1.11.11.11.1-1.21.11.2-1.1-1.1-1.21.2-1.4-0.0-1.0-1.5
Locomotion distance, session 80.40.52.40.5-0.6-0.6-0.70.7-0.6-0.50.50.50.8-0.50.6-0.31.60.9
Degree of sensitization distance0.20.21.2-0.1-0.0-0.1-0.10.4-0.3-0.00.10.00.4-0.00.1-0.61.10.7
Degree of sensitization stereotypy0.50.51.8-0.90.70.70.7-0.70.70.6-0.7-0.7-0.60.7-0.3-1.4-0.10.4
Conditioned locomotion1.61.92.4-1.41.51.51.4-1.41.51.5-1.5-1.4-1.51.5-1.5-0.7-1.0-1.2
Cocaine response after cond. corrected1.61.82.41.5-1.4-1.4-1.51.4-1.5-1.31.41.41.5-1.31.01.41.10.4
Cocaine response after cond. not corrected1.31.41.81.3-1.2-1.3-1.31.3-1.3-1.11.21.21.3-1.20.91.21.10.4
Cocaine response before conditioning0.70.91.2-1.11.01.01.0-1.01.00.9-1.0-1.0-1.01.0-0.7-1.0-0.5-0.3
Saline control response4.25.56.9-2.62.62.52.5-2.42.32.5-2.5-2.6-2.42.5-2.6-1.6-1.4-1.8
Bone: connectivity density1.93.07.5-1.91.91.81.8-1.61.41.8-1.9-2.1-1.32.0-1.5-2.7-0.10.1
Bone: cortical apparent density0.30.51.7-0.60.60.60.7-0.80.60.7-0.6-0.6-0.70.5-0.7-0.2-1.3-0.5
Bone: cortical area0.71.01.7-1.21.11.11.1-0.81.31.0-1.1-1.1-1.01.3-0.8-0.9-0.4-0.4
Bone: cortical porosity0.10.10.6-0.30.30.20.2-0.10.00.3-0.2-0.30.00.2-0.2-0.80.20.5
Bone: cortical porosity0.50.51.0-0.80.80.80.8-0.70.50.8-0.8-0.8-0.60.7-0.8-1.0-0.3-0.0
Bone: cortical thickness3.35.57.0-2.42.42.42.5-2.22.72.3-2.3-2.2-2.42.6-2.4-0.6-2.7-2.3
Bone: cortical thickness1.01.12.8-0.91.00.91.0-0.81.00.9-0.9-0.8-1.01.0-1.30.5-1.7-1.5
Bone: cortical tissue density0.50.62.1-0.60.70.70.8-0.90.70.8-0.7-0.7-0.80.6-0.8-0.2-1.4-0.7
Condit. Reinf. active minus inactive responses0.10.20.4-0.30.40.40.4-0.30.40.5-0.4-0.5-0.20.6-0.4-0.6-0.10.1
Condit. Reinf. active-inactive response ratio0.00.00.30.10.10.10.1-0.20.20.2-0.2-0.2-0.10.3-0.2-0.1-0.60.1
Condit. Reinf. active responses0.10.10.6-0.20.20.10.20.00.20.3-0.2-0.20.00.5-0.0-0.80.60.6
Condit. Reinf. inactive responses0.30.32.20.0-0.2-0.2-0.20.5-0.2-0.10.20.20.4-0.00.5-0.71.51.0
Incentive salience index mean0.30.31.1-0.50.60.50.5-0.40.50.7-0.6-0.7-0.30.8-0.5-1.10.40.4
Condit. Reinf. lever presses0.30.40.9-0.60.70.60.6-0.50.70.7-0.6-0.6-0.50.7-0.4-1.00.60.2
Condit. Reinf. active minus inactive responses0.20.20.90.4-0.4-0.4-0.40.4-0.3-0.40.30.20.4-0.20.7-0.50.70.9
Condit. Reinf. active-inactive response ratio1.01.02.90.9-0.9-0.9-0.91.0-0.7-0.90.80.70.9-0.71.4-0.41.71.5
Condit. Reinf. active responses0.10.10.9-0.20.20.20.2-0.20.00.1-0.3-0.40.10.30.0-1.00.10.7
Condit. Reinf. inactive responses0.30.40.7-0.60.70.60.7-0.60.20.7-0.6-0.8-0.30.6-0.8-0.7-0.7-0.2
Condit. Reinf. lever presses2.33.14.4-1.91.91.91.9-1.81.91.8-1.9-2.0-1.72.1-1.4-2.1-0.7-0.6
Condit. Reinf. lever reinforcers received0.20.31.3-0.50.60.60.6-0.60.40.5-0.6-0.8-0.40.6-0.3-1.1-0.20.3
Conditioned reinforcement - actives0.20.20.40.5-0.4-0.4-0.30.4-0.3-0.60.40.40.3-0.40.60.40.50.1
Conditioned reinforcement - inactives5.96.69.02.7-2.9-2.7-2.72.7-2.5-2.82.82.82.5-2.63.01.91.42.0
Conditioned locomotion7.89.411.73.3-3.4-3.3-3.23.2-3.1-3.43.33.42.9-3.33.32.91.71.6
Patch foraging indifference point 0 sec0.00.10.10.1-0.3-0.2-0.20.2-0.3-0.30.30.20.2-0.30.3-0.00.20.3
Patch foraging indifference point AUC4.14.75.8-2.32.22.42.3-2.42.32.2-2.3-2.3-2.22.3-2.0-1.7-2.0-1.3
Delay disc. indifference point, 0s delay0.60.61.41.0-0.6-0.8-0.90.7-1.2-0.70.60.61.1-1.00.60.10.71.0
Delay disc. indifference point, 16s delay1.11.12.80.9-1.0-1.1-1.01.0-1.0-1.11.00.91.1-0.91.2-0.20.81.7
Delay disc. indifference point, 2s delay0.10.20.40.4-0.3-0.3-0.40.4-0.4-0.40.30.30.4-0.30.4-0.10.70.5
Delay disc. indifference point, 24s delay0.10.10.50.3-0.2-0.4-0.30.2-0.3-0.30.20.30.3-0.4-0.10.7-0.5-0.3
Delay disc. indifference point, 4s delay0.20.20.60.5-0.4-0.5-0.50.5-0.8-0.40.40.30.7-0.50.20.20.20.4
Delay disc. indifference point, 8s delay0.10.10.30.3-0.1-0.3-0.30.2-0.5-0.20.10.10.5-0.4-0.00.1-0.10.2
Indifference point function ln k9.012.515.53.7-3.7-3.9-3.73.9-3.7-3.73.83.83.7-3.83.23.22.82.1
Indifference point function log k9.012.515.53.7-3.7-3.9-3.73.9-3.7-3.73.83.83.7-3.83.23.22.82.1
Patch foraging total patch changes 0 sec0.00.00.10.0-0.2-0.1-0.10.1-0.1-0.10.20.20.0-0.20.00.3-0.2-0.3
Patch foraging total patch changes 12 sec5.26.78.4-2.92.72.82.8-2.72.62.7-2.7-2.8-2.52.7-2.5-2.4-1.9-1.3
Patch foraging total patch changes 18 sec0.60.71.5-0.90.80.90.8-1.00.80.9-0.9-1.0-0.80.9-0.6-1.2-0.3-0.1
Patch foraging total patch changes 24 sec2.93.54.6-2.01.92.01.9-2.21.91.9-1.9-1.9-2.01.8-2.0-0.9-1.7-1.9
Patch foraging total patch changes 6 sec1.11.62.7-1.61.31.31.3-1.31.21.3-1.3-1.4-1.21.5-1.3-1.2-0.7-0.7
Patch foraging time to switch 0 sec1.72.68.5-1.81.71.51.5-1.41.31.7-1.7-1.8-1.21.8-1.1-2.90.50.7
Patch foraging water rate 0 sec3.65.811.72.8-2.7-2.5-2.52.3-2.2-2.62.62.82.0-2.62.23.40.40.1
Patch foraging water rate 12 sec8.012.223.74.0-3.7-3.7-3.63.5-3.5-3.83.83.93.2-3.92.84.90.90.3
Patch foraging water rate 18 sec3.24.46.82.4-2.3-2.2-2.32.2-2.1-2.22.32.32.0-2.11.72.61.20.4
Patch foraging water rate 24 sec4.25.810.62.8-2.6-2.6-2.62.4-2.3-2.62.52.72.1-2.72.13.20.90.3
Patch foraging water rate 6 sec3.75.312.12.6-2.5-2.5-2.52.3-2.2-2.42.52.62.0-2.41.73.50.8-0.1
Seeking ratio, delayed vs. immediate footshock0.10.10.8-0.1-0.1-0.3-0.10.3-0.3-0.20.20.10.3-0.20.2-0.60.40.9
Distance traveled before self-admin0.60.60.9-0.80.90.90.9-0.90.80.8-0.8-0.8-0.80.6-0.5-1.0-0.4-0.2
Distance traveled after self-admin0.30.30.6-0.60.60.60.6-0.60.60.5-0.5-0.4-0.50.4-0.3-0.6-0.8-0.1
Extensor digitorum longus weight7.529.636.1-5.96.05.95.8-5.65.75.9-5.9-5.9-5.55.9-5.5-4.7-3.0-3.1
Bone: elastic displacement1.01.15.11.0-1.0-1.0-0.91.1-0.8-1.11.11.20.9-0.90.52.3-0.4-0.7
Bone: elastic work0.91.22.5-1.21.11.01.1-0.81.11.0-1.0-0.9-1.01.1-1.40.4-1.4-1.6
Bone: endosteal estimation1.43.010.31.3-1.4-1.5-1.71.8-1.7-1.51.41.31.8-1.51.7-0.43.22.4
Bone: endosteal perimeter1.73.510.81.5-1.6-1.6-1.81.9-1.8-1.61.51.41.9-1.52.1-0.63.32.6
Epididymis fat weight2.96.78.22.6-2.7-2.7-2.72.7-2.8-2.82.62.62.7-2.72.91.22.72.3
Delta time in closed arm before/after self-admin0.10.10.5-0.10.20.00.10.00.00.1-0.1-0.1-0.00.2-0.60.6-0.1-0.7
Delta time in open arm before/after self-admin0.10.10.7-0.30.30.40.3-0.40.40.2-0.2-0.2-0.40.10.1-0.4-0.80.0
Diff in mean of infusions in LGA sessions0.50.61.1-0.70.80.80.8-0.80.90.7-0.7-0.7-0.80.8-0.7-0.2-1.0-0.8
Delay discount exponential model param0.10.10.4-0.30.10.30.2-0.20.50.2-0.1-0.1-0.50.3-0.20.3-0.0-0.6
Extinction: sum of active levers before priming4.74.76.5-2.42.42.32.4-2.12.32.3-2.3-2.4-2.12.4-2.0-2.6-1.1-0.5
Active lever presses in extinction session 62.72.63.8-1.51.71.81.7-1.81.91.6-1.7-1.6-1.91.6-1.5-0.7-1.3-1.7
Bone: final force2.74.45.5-2.32.32.32.2-2.12.22.3-2.3-2.3-2.22.3-2.0-2.1-0.9-1.0
Bone: final moment2.43.94.8-2.22.12.22.0-2.02.12.2-2.2-2.2-2.02.2-1.9-1.9-0.8-1.0
Food consumed during 24 hour testing period0.10.10.7-0.20.20.30.3-0.40.40.2-0.2-0.1-0.50.2-0.10.3-0.9-0.5
Glucose2.43.75.81.9-1.9-1.9-2.01.9-2.2-1.81.81.72.1-1.82.00.22.42.2
Heart weight3.65.16.42.3-2.4-2.5-2.42.4-2.5-2.32.42.32.5-2.12.21.51.91.7
Delay discount hyperbolic model param0.10.10.3-0.20.10.20.2-0.20.40.2-0.1-0.1-0.40.3-0.10.3-0.0-0.5
Intermittent access intake day 1-15 change0.50.51.00.8-0.9-0.8-0.70.7-0.4-0.80.80.90.4-0.60.81.00.1-0.0
Intermittent access intake escalation0.50.50.80.8-0.9-0.8-0.70.7-0.5-0.80.80.80.5-0.60.90.70.30.3
Intermittent access intake escalation 20.20.20.50.4-0.4-0.3-0.30.2-0.0-0.40.40.50.0-0.40.40.7-0.4-0.3
Intermitt. access day 1 inactive lever presses2.42.63.51.7-1.8-1.7-1.71.7-1.6-1.71.71.81.7-1.51.90.90.91.5
Intermitt. access day 15 inactive lever presses2.42.74.01.8-1.8-1.7-1.71.8-1.5-1.71.81.71.7-1.32.00.81.21.5
Intermitt. access escalation Index3.83.44.71.9-1.8-1.9-1.92.0-2.2-1.81.81.72.2-1.91.80.81.61.9
Intermittent access day 1 total infusions6.87.813.32.7-2.7-2.7-2.82.9-3.1-2.62.62.33.2-2.43.00.23.63.5
Intermittent access day 15 total infusions8.89.812.53.3-3.3-3.3-3.23.3-3.2-3.33.23.03.3-2.83.51.53.22.9
Intermittent access terminal intake (last 3 days)6.47.010.22.7-2.7-2.7-2.72.8-2.7-2.72.62.42.8-2.33.10.83.22.8
Intermittent access total infusions5.66.210.52.5-2.4-2.5-2.52.6-2.6-2.42.32.12.8-2.02.80.33.23.0
Intermittent access day 1 locomotion4.95.19.92.1-2.1-2.2-2.32.4-2.5-2.12.01.82.7-1.82.30.13.12.9
Intermittent access day 15 total locomotion5.45.87.62.5-2.5-2.5-2.52.6-2.5-2.52.42.32.6-2.12.80.92.42.5
Intermittent access total locomotion7.68.714.12.8-2.9-2.9-3.03.1-3.1-2.82.72.53.2-2.53.30.33.83.7
Intermittent access standard deviation1.11.22.01.4-1.2-1.1-1.11.1-1.0-1.21.21.21.0-1.01.21.10.50.5
Left kidney weight0.71.92.81.4-1.5-1.4-1.41.4-1.1-1.41.41.51.3-1.41.70.71.21.3
Right kidney weight0.10.30.90.5-0.6-0.5-0.50.3-0.0-0.60.50.70.2-0.51.00.40.30.4
Cocaine induced anxiety0.00.00.1-0.10.10.00.0-0.00.1-0.00.00.1-0.10.00.10.10.3-0.1
Post-drug Anxiety1.31.52.2-1.51.31.31.3-1.31.51.2-1.2-1.1-1.51.2-1.1-0.6-0.5-1.3
Baseline Anxiety2.62.83.7-1.81.71.81.7-1.71.91.8-1.7-1.7-1.91.7-1.8-0.8-1.3-1.6
Tail length0.92.87.0-1.11.41.61.5-1.71.71.5-1.5-1.3-1.81.4-1.80.8-2.5-2.6
Length with tail2.48.810.7-2.93.03.13.1-3.13.33.0-3.0-2.9-3.23.2-3.1-1.0-2.7-3.0
Length without tail2.75.98.0-2.82.62.52.6-2.32.72.5-2.5-2.5-2.62.8-2.5-1.6-1.4-1.8
Times rat made contact with spout0.50.51.0-0.70.80.70.8-0.80.50.8-0.7-0.8-0.60.8-0.9-0.5-1.0-0.4
Lifetime Intake4.95.59.82.4-2.3-2.3-2.32.5-2.5-2.32.21.92.7-1.82.60.23.12.9
Liver weight, left0.10.10.20.3-0.3-0.3-0.30.3-0.3-0.30.30.30.2-0.40.30.20.40.3
Liver weight, right0.10.10.60.2-0.2-0.3-0.30.4-0.4-0.30.30.30.2-0.30.00.50.8-0.1
Locomotor activity1.62.56.81.7-1.7-1.8-1.71.5-1.5-1.71.71.81.3-1.51.12.60.2-0.4
Locomotor testing distance2.23.710.62.1-2.0-2.1-2.01.9-1.9-2.12.12.11.7-1.91.13.30.2-0.6
Locomotor testing rearing2.13.26.12.0-1.9-1.9-1.91.8-2.1-2.01.91.81.9-1.81.22.50.2-0.0
Locomotion in novel chamber4.96.07.82.6-2.6-2.5-2.62.5-2.4-2.62.62.62.4-2.62.81.62.31.9
Locomotion in novel chamber post-restriction3.13.74.52.0-2.1-2.0-2.12.0-1.9-2.12.12.01.9-1.92.11.31.61.4
Fecal boli incidents, locomotor time 10.10.10.5-0.20.10.20.1-0.30.30.0-0.2-0.2-0.40.20.4-0.70.30.5
Change in fecal boli incidents, locomotor task0.00.00.2-0.00.1-0.1-0.10.2-0.30.10.1-0.00.2-0.2-0.40.10.5-0.1
Time >=10cm from walls, locomotor time 11.61.66.40.7-0.9-0.9-1.11.0-1.1-0.90.80.71.1-0.91.5-1.02.52.2
Bouts of movement, locomotor time 11.81.95.5-1.41.31.41.4-1.61.51.3-1.3-1.2-1.41.1-1.3-0.8-2.3-1.0
Total resting periods, locomotor time 11.21.33.4-1.21.11.21.2-1.31.21.1-1.1-1.1-1.21.0-1.0-0.9-1.8-0.6
Rest time, locomotor task time 11.21.31.91.3-1.2-1.1-1.21.1-1.0-1.31.21.31.0-1.31.11.40.50.1
Distance moved, locomotor task time 10.20.21.0-0.30.40.20.3-0.00.10.3-0.3-0.40.10.4-0.2-1.00.70.8
Vertical activity count, locomotor time 11.31.41.91.2-1.2-1.3-1.21.4-1.2-1.21.31.21.2-1.11.20.91.00.9
Time >=10cm from walls, locomotor time 20.00.00.3-0.10.10.20.1-0.30.10.1-0.2-0.1-0.1-0.10.2-0.5-0.00.4
Bouts of movement, locomotor time 20.60.61.8-0.80.80.70.9-0.90.80.8-0.7-0.7-0.70.7-0.7-0.8-1.3-0.2
Total resting periods, locomotor time 20.30.31.0-0.60.50.40.6-0.60.50.6-0.5-0.5-0.40.4-0.4-0.8-1.00.1
Rest time, locomotor task time 22.52.93.81.9-1.8-1.8-1.91.6-1.8-1.91.71.81.8-1.91.81.21.21.2
Distance moved, locomotor task time 21.21.41.8-1.21.31.31.3-1.21.31.2-1.2-1.2-1.21.3-1.3-0.7-1.0-1.0
Vertical activity count, locomotor time 20.30.32.0-0.0-0.0-0.00.00.10.20.00.10.2-0.30.0-0.51.4-0.7-1.4
Light reinforcement 10.10.20.70.5-0.5-0.4-0.40.2-0.5-0.50.40.40.3-0.70.30.9-0.5-0.4
Light reinforcement 20.81.12.21.1-1.1-1.0-1.01.0-0.8-1.31.01.10.9-1.11.50.61.00.9
Bone: marrow area1.53.210.61.4-1.5-1.6-1.71.8-1.8-1.51.41.31.9-1.51.8-0.43.32.4
Bone: maximum diameter0.10.20.4-0.50.40.50.4-0.30.70.4-0.5-0.5-0.50.5-0.1-0.60.40.0
Bone: maximum force3.05.210.2-2.62.52.42.3-2.22.32.5-2.5-2.6-2.02.6-1.9-3.2-0.0-0.2
Bone: maximum moment2.64.48.7-2.42.32.22.1-2.02.12.3-2.3-2.4-1.82.4-1.8-3.00.0-0.1
Mean time between licks in bursts0.60.92.1-1.00.90.80.8-0.90.71.0-0.8-0.8-1.00.7-1.40.4-1.0-1.5
Mean num. licks in bursts0.20.20.40.6-0.5-0.4-0.40.5-0.6-0.50.40.40.6-0.50.20.5-0.20.0
Cd content in liver1.21.32.01.4-1.3-1.2-1.21.1-1.0-1.31.21.30.9-1.41.41.10.40.4
Co content in liver1.41.65.61.4-1.3-1.2-1.21.1-1.2-1.31.31.41.0-1.40.72.4-1.0-0.6
Cu content in liver0.30.40.9-0.80.60.60.7-0.50.60.6-0.6-0.7-0.40.8-0.5-0.9-0.60.2
Fe content in liver0.10.20.4-0.70.50.40.5-0.30.50.3-0.4-0.4-0.40.3-0.3-0.20.2-0.4
K content in liver1.51.53.7-1.41.31.21.2-1.11.11.3-1.3-1.5-0.91.5-1.1-1.90.30.2
Mg content in liver0.40.42.7-0.30.30.10.1-0.0-0.20.3-0.3-0.50.30.4-0.0-1.61.11.3
Mn content in liver2.73.04.0-2.01.81.91.9-1.91.91.8-1.9-1.9-1.82.0-1.5-1.7-0.9-0.8
Na content in liver1.21.31.9-1.11.21.31.2-1.21.41.2-1.2-1.1-1.31.2-1.0-0.6-0.8-0.9
Rb content in liver1.62.03.01.2-1.4-1.5-1.41.6-1.7-1.51.41.31.7-1.41.40.31.21.7
Se content in liver0.10.10.8-0.1-0.0-0.00.10.00.0-0.1-0.0-0.10.10.30.4-0.90.70.7
Sr content in liver3.83.55.2-1.81.82.01.9-2.12.01.8-1.9-1.7-2.11.6-1.8-0.5-2.3-1.9
Zn content in liver1.11.21.7-1.11.21.21.2-1.11.11.2-1.2-1.2-1.01.3-1.0-1.3-0.8-0.2
Bone: minimum diameter1.32.46.91.0-1.2-1.3-1.31.6-1.5-1.31.21.01.8-1.11.6-0.92.62.6
Time in familiar zone, hab. session 10.40.41.30.4-0.5-0.5-0.50.6-0.6-0.50.50.40.6-0.50.5-0.11.10.9
Time in novel zone, hab. session 10.30.31.50.5-0.4-0.3-0.40.2-0.4-0.30.40.50.2-0.40.01.2-0.7-0.8
Total zone transitions, hab. session 10.71.01.4-1.11.11.01.1-0.91.01.0-1.1-1.1-0.81.2-0.9-1.2-0.5-0.1
Total locomotion distance, hab. session 10.40.61.50.6-0.6-0.7-0.80.8-0.7-0.70.60.60.8-0.70.8-0.21.21.2
Locomotion velocity, hab. session 10.10.10.70.1-0.1-0.2-0.20.3-0.2-0.20.10.10.4-0.20.3-0.50.70.9
Time in familiar zone, hab. session 20.20.21.10.1-0.0-0.0-0.00.1-0.10.00.10.1-0.1-0.1-0.41.1-0.2-1.0
Time in novel zone, hab. session 20.10.11.0-0.20.20.20.2-0.30.10.2-0.3-0.3-0.00.30.1-1.00.00.7
Total zone transitions, hab. session 21.21.65.3-1.31.41.21.2-1.20.71.3-1.4-1.6-0.71.3-1.2-2.30.40.5
Total locomotion distance, hab. session 20.30.42.00.2-0.1-0.3-0.30.3-0.5-0.10.1-0.00.6-0.20.2-1.01.41.3
Locomotion velocity, hab. session 20.40.63.00.4-0.3-0.5-0.50.5-0.7-0.30.30.20.8-0.40.5-1.01.71.5
Novel to familiar place preference ratio1.11.12.8-1.11.11.11.1-1.11.11.1-1.1-1.2-1.01.1-0.6-1.7-0.40.2
Novelty place preference0.50.51.8-0.70.70.70.7-0.70.70.6-0.7-0.8-0.60.6-0.2-1.3-0.30.4
Time in novel zone, NPP test0.30.31.3-0.60.60.60.6-0.60.60.5-0.6-0.6-0.50.5-0.2-1.1-0.30.3
Total zone transitions, NPP test2.13.04.3-1.81.91.91.8-1.81.61.9-2.0-2.0-1.61.9-1.7-2.1-0.6-0.4
Total locomotion distance, NPP test0.10.10.7-0.10.20.10.1-0.10.00.2-0.2-0.20.10.2-0.1-0.80.60.7
Locomotion velocity, NPP test0.10.10.9-0.30.30.20.2-0.20.20.3-0.3-0.3-0.00.3-0.1-0.90.50.7
Intraocular pressure0.71.01.61.1-1.2-1.0-1.00.7-0.7-1.11.11.30.7-1.21.31.20.10.2
Delta distance traveled before/after self-admin0.00.00.20.1-0.1-0.2-0.10.2-0.1-0.20.20.20.1-0.1-0.10.5-0.4-0.3
Delta ambulatory time before/after self-admin0.10.10.3-0.00.0-0.10.00.1-0.0-0.10.10.10.0-0.0-0.30.5-0.5-0.5
Parametrial fat weight3.05.89.72.1-2.4-2.3-2.52.3-2.5-2.22.22.22.5-2.52.60.23.13.0
Pavlov. Cond. lever latency0.20.30.70.7-0.6-0.5-0.50.5-0.4-0.50.60.60.4-0.50.40.8-0.4-0.2
Pavlov. Cond. magazine entry latency0.20.31.9-0.30.40.40.3-0.30.20.4-0.5-0.5-0.00.2-0.0-1.40.40.9
Pavlov. Cond. change in total contacts0.20.21.3-0.30.10.10.2-0.20.20.1-0.2-0.2-0.10.10.3-1.10.41.1
Pavlov. Cond. index score0.10.10.4-0.40.40.40.4-0.40.40.3-0.4-0.4-0.30.2-0.1-0.7-0.10.2
Pavlov. Cond. latency score0.10.10.4-0.20.20.20.2-0.20.20.2-0.3-0.2-0.10.1-0.0-0.60.20.4
Pavlov. Cond. lever contacts0.00.00.1-0.20.10.00.1-0.00.00.1-0.1-0.10.0-0.0-0.0-0.30.40.3
Pavlov. Cond. magazine entry number0.20.30.50.5-0.5-0.6-0.60.7-0.7-0.50.60.50.6-0.40.20.70.60.1
Pavlov. Cond. intertrial magazine entries0.30.40.60.5-0.7-0.7-0.50.7-0.4-0.80.80.70.6-0.40.80.6-0.00.3
Pavlov. Cond. lever-magazine prob. diff.0.30.30.9-0.60.60.60.6-0.60.60.6-0.7-0.6-0.50.5-0.3-0.9-0.10.2
Pavlov. Cond. response bias0.10.10.3-0.40.30.30.4-0.40.40.3-0.4-0.3-0.30.3-0.1-0.5-0.30.1
Pavlov. Cond. lever latency0.50.71.30.8-0.9-0.9-0.90.8-0.9-0.80.90.90.8-0.90.51.1-0.00.1
Pavlov. Cond. magazine entry latency3.74.35.6-2.32.32.22.2-2.12.12.2-2.2-2.4-1.92.4-1.9-2.3-1.3-0.6
Pavlov. Cond. change in total contacts2.02.76.4-1.81.71.71.8-1.61.81.6-1.8-1.9-1.51.9-1.0-2.5-0.60.3
Pavlov. Cond. index score2.53.25.3-1.91.91.91.9-1.81.91.8-1.9-2.0-1.72.1-1.4-2.3-0.7-0.3
Pavlov. Cond. latency score2.02.54.5-1.71.71.71.7-1.51.71.6-1.7-1.8-1.51.9-1.2-2.1-0.4-0.1
Pavlov. Cond. lever contacts0.50.71.1-0.90.91.00.9-0.91.00.8-0.9-0.9-1.00.9-0.6-0.7-0.5-0.6
Pavlov. Cond. magazine entry number6.78.110.33.1-3.1-3.1-3.12.9-2.9-3.03.13.22.7-3.22.63.11.91.0
Pavlov. Cond. intertrial magazine entries1.31.72.21.5-1.4-1.4-1.41.3-1.3-1.31.31.41.2-1.41.31.11.10.7
Pavlov. Cond. lever-magazine prob. diff.3.03.95.8-2.12.12.12.1-2.02.12.0-2.1-2.2-1.82.2-1.6-2.4-0.9-0.4
Pavlov. Cond. response bias1.92.63.2-1.71.71.81.7-1.71.71.6-1.7-1.8-1.71.8-1.3-1.7-1.0-0.7
Time in closed arm before self-admin0.10.10.4-0.20.10.20.1-0.20.10.1-0.2-0.1-0.20.00.2-0.60.30.4
Time in closed arm after self-admin0.10.10.50.0-0.1-0.2-0.20.3-0.2-0.10.20.20.2-0.10.00.00.70.3
Time in open arm before self-admin0.60.61.50.9-0.8-1.0-0.70.9-0.9-0.70.80.70.9-0.60.11.20.2-0.1
Time in open arm after self-admin0.20.20.90.4-0.5-0.4-0.30.2-0.3-0.40.40.40.2-0.40.21.0-0.8-0.4
Bone: periosteal estimation0.20.42.9-0.0-0.2-0.2-0.30.5-0.1-0.30.10.10.4-0.00.6-0.81.71.1
Bone: periosteal perimeter0.10.21.0-0.40.30.30.2-0.00.20.2-0.3-0.4-0.10.40.0-1.00.90.6
Bone: post-yield work1.72.314.4-0.60.50.40.3-0.20.00.6-0.6-0.90.30.60.5-3.82.92.9
Progressive ratio test 1 active lever presses3.03.14.32.1-1.9-1.8-1.81.9-1.9-1.91.81.72.0-1.61.91.11.31.5
Progressive ratio test 1 breakpoint2.62.73.92.0-1.8-1.7-1.71.8-1.8-1.81.71.61.8-1.51.81.21.11.2
Progressive ratio test 1 inactive lever presses1.31.41.91.4-1.3-1.2-1.21.3-1.3-1.21.21.21.4-1.11.20.70.71.1
Progressive ratio test 2 active lever presses4.54.86.52.5-2.3-2.3-2.22.4-2.3-2.32.32.12.4-1.92.61.02.12.1
Progressive ratio test 2 breakpoint5.46.07.92.8-2.7-2.6-2.52.7-2.5-2.62.62.52.6-2.22.81.71.91.9
Progressive ratio test 2 inactive lever presses9.210.713.93.4-3.4-3.4-3.33.4-3.5-3.43.43.23.5-3.23.71.52.93.1
Incentive Sensitization - Responses0.50.51.00.7-0.7-0.7-0.60.8-0.6-0.70.70.50.8-0.40.9-0.11.01.0
Incentive Sensitization - Breakpoint0.70.81.20.9-0.9-0.9-0.71.0-0.8-0.90.90.70.9-0.61.10.01.11.1
Sum of active levers in priming session hrs 5-62.01.93.6-1.31.31.41.5-1.51.91.2-1.3-1.2-1.81.4-1.0-0.4-1.4-1.5
Progressive ratio1.92.27.5-1.61.61.51.4-1.41.11.5-1.6-1.8-1.01.5-1.1-2.70.50.7
Food seeking constrained by brief footshock0.20.30.6-0.60.50.40.5-0.30.50.5-0.4-0.5-0.50.5-0.80.1-0.4-0.7
Seeking ratio, punishment vs. effort1.62.07.21.4-1.5-1.5-1.31.4-1.2-1.41.51.61.1-1.40.82.7-0.4-0.7
Retroperitoneal fat weight5.819.222.04.3-4.6-4.7-4.64.7-4.6-4.64.54.44.6-4.44.72.34.33.9
Reaction time number correct0.40.61.2-0.50.80.90.7-0.80.90.7-0.8-0.7-0.80.7-0.80.2-0.9-1.1
Reaction time mean minus median3.04.05.4-2.32.12.02.1-2.22.22.1-2.1-2.1-2.12.2-1.6-2.3-0.7-0.6
Reaction time mean minus median AUC1.82.33.1-1.71.61.51.6-1.71.81.6-1.5-1.5-1.71.7-1.3-1.3-0.8-0.8
Reaction time num false alarms0.20.31.50.5-0.5-0.6-0.40.7-0.4-0.40.70.60.4-0.40.01.20.2-0.3
Reaction time num false alarms AUC0.10.10.4-0.30.20.10.30.00.30.2-0.0-0.1-0.20.3-0.60.6-0.3-0.7
Reaction time trials correct on left0.40.61.2-0.50.80.90.7-0.80.90.7-0.8-0.7-0.80.7-0.80.2-0.9-1.1
Reaction time trials on left0.50.81.5-0.60.91.00.8-0.91.00.8-0.9-0.8-0.90.8-0.90.2-1.0-1.2
Reaction time mean0.10.10.4-0.20.20.20.2-0.30.30.3-0.2-0.1-0.40.20.1-0.6-0.10.4
Reaction time mean AUC0.10.10.6-0.20.10.10.2-0.20.20.2-0.1-0.1-0.20.10.3-0.70.00.6
Median of all reaction times0.10.10.50.3-0.3-0.2-0.30.2-0.2-0.10.30.30.1-0.30.5-0.30.10.7
Reaction time omissions1.41.92.5-1.61.61.41.5-1.41.61.4-1.5-1.4-1.41.6-1.3-1.2-1.0-0.6
Reaction time false alarm rate0.20.20.60.4-0.5-0.6-0.50.7-0.5-0.40.70.50.5-0.30.10.80.40.0
Reaction time premature initiation rate2.73.65.6-1.91.91.91.9-2.01.82.0-1.8-1.8-2.01.7-2.4-0.3-2.1-2.3
Reaction time premature initiations4.56.49.1-2.42.62.62.6-2.72.52.5-2.5-2.4-2.72.3-3.0-0.3-2.9-3.0
Std. dev. reaction times0.81.21.7-1.31.11.11.2-1.21.21.2-1.1-1.1-1.21.1-0.7-1.3-0.5-0.3
Reaction time trials completed0.50.81.5-0.60.91.00.8-0.91.00.8-0.9-0.8-0.90.8-0.90.2-1.0-1.2
Reaction time trials AUC0.30.51.1-0.50.70.70.6-0.70.80.6-0.7-0.6-0.70.6-0.80.3-0.8-1.0
Run reversals in cocaine runway, females0.40.41.5-0.70.70.50.4-0.30.20.7-0.6-0.7-0.10.6-0.6-1.20.80.6
Run reversals in cocaine runway, males0.40.42.60.5-0.6-0.4-0.50.4-0.1-0.50.50.60.0-0.40.21.6-0.5-1.0
Latency to leave start box in cocaine runway0.30.31.4-0.0-0.1-0.2-0.10.3-0.2-0.20.20.10.4-0.10.4-0.91.11.2
Latency to leave start box in cocaine runway, F0.10.10.7-0.10.0-0.00.00.0-0.0-0.0-0.0-0.10.20.00.2-0.80.20.8
Latency to leave start box in cocaine runway, M0.10.11.2-0.20.1-0.10.00.2-0.0-0.10.20.10.10.10.1-0.31.10.3
Std. dev. time between licks in bursts0.20.21.70.2-0.1-0.2-0.20.2-0.3-0.10.30.30.0-0.3-0.41.3-0.2-0.9
Total sessions with >9 infusions2.22.45.01.4-1.4-1.5-1.61.7-1.7-1.41.41.31.8-1.31.50.32.21.8
Short access day 1 total inactive lever presses3.94.45.32.0-2.2-2.2-2.22.3-2.3-2.22.22.12.3-2.12.31.11.72.0
Short access day 10 total inactive lever presses3.53.94.82.1-2.2-2.2-2.12.2-2.1-2.12.22.22.1-2.01.91.81.01.2
Short access day 1 total infusions3.74.07.21.9-1.8-1.9-2.02.1-2.2-1.91.81.62.3-1.72.10.02.52.7
Short access day 10 total infusions2.62.98.91.4-1.2-1.4-1.41.7-1.8-1.31.20.82.0-0.91.7-1.13.02.9
Short access total infusions2.02.25.91.3-1.2-1.3-1.41.5-1.7-1.31.21.01.8-1.01.5-0.32.42.2
Short access day 1 locomotion3.13.46.31.8-1.7-1.9-1.92.0-2.0-1.71.71.42.2-1.31.90.12.52.3
Short access day 10 total locomotion2.12.44.91.5-1.3-1.5-1.51.7-1.7-1.51.31.11.9-1.11.6-0.22.12.2
Short access total locomotion1.92.04.11.3-1.2-1.3-1.31.5-1.6-1.21.21.01.8-1.01.4-0.22.02.0
One hour access (0.3 mA shock)10.612.415.74.0-3.7-3.7-3.73.7-3.7-3.73.73.63.7-3.43.82.42.92.7
Compulsive drug intake3.33.36.5-1.51.81.81.9-1.81.71.8-1.7-1.6-1.81.6-2.2-0.2-2.5-2.2
One hour access (shock baseline)9.611.115.33.6-3.6-3.5-3.53.5-3.3-3.53.43.33.4-3.13.91.73.23.0
Social response proportion0.90.91.3-1.11.01.01.0-1.10.91.1-1.0-1.0-1.01.0-0.9-1.0-0.5-0.6
Social responses0.30.41.0-0.60.50.60.6-0.60.50.6-0.5-0.5-0.70.7-0.70.1-0.7-1.0
Social time0.40.61.5-0.60.70.70.6-0.70.70.7-0.8-0.7-0.70.7-1.00.2-0.9-1.2
Soleus weight4.312.614.93.8-3.8-3.8-3.93.8-3.6-3.83.73.83.6-3.83.62.82.82.3
Bone: stiffness2.43.99.0-2.22.12.12.0-1.91.92.1-2.2-2.2-1.72.2-1.5-3.0-0.10.1
Tibialis anterior weight11.338.646.3-6.66.76.76.6-6.66.86.5-6.6-6.5-6.76.6-6.2-4.0-4.3-4.7
Time to tail flick, vehicle, before self-admin0.40.41.2-0.60.70.60.6-0.60.50.7-0.7-0.8-0.50.6-0.5-1.10.60.1
Time to tail flick, vehicle, after self-admin1.01.11.7-1.11.10.91.0-1.00.81.2-1.2-1.3-0.81.2-1.2-1.20.3-0.4
Time to tail flick, test, before self-admin1.21.13.60.9-1.0-1.0-1.11.1-1.2-0.80.80.71.3-0.70.8-0.11.91.4
Time to tail flick, test, after self-admin0.00.00.2-0.10.00.00.0-0.20.10.1-0.1-0.1-0.20.1-0.20.3-0.2-0.5
Delta time to tail flick, vehicle, before/after SA0.30.30.6-0.70.60.50.5-0.60.50.7-0.6-0.7-0.40.7-0.7-0.6-0.2-0.3
Delta time to tail flick, test, before/after SA2.11.94.8-1.21.01.11.3-1.51.51.1-1.2-0.9-1.61.0-1.20.4-2.2-2.1
Tibia length1.13.15.1-2.11.92.01.9-1.92.21.7-1.9-1.7-2.01.9-1.2-1.5-0.9-1.0
Ambulatory time before self-admin0.40.41.1-0.70.60.70.7-0.70.80.6-0.6-0.6-0.70.6-0.2-1.0-0.10.1
Ambulatory time after self-admin0.10.21.00.1-0.1-0.1-0.10.2-0.2-0.30.30.20.3-0.30.6-0.70.11.0
Bone: tissue strength0.00.00.3-0.20.10.10.1-0.20.20.2-0.2-0.2-0.10.20.0-0.50.30.2
Total heroin consumption5.96.98.1-2.82.72.82.8-2.82.82.8-2.8-2.8-2.72.7-2.6-2.2-1.9-1.7
Bone: trabecular number0.50.84.4-0.90.80.80.7-0.60.50.7-0.8-1.0-0.31.0-0.3-2.10.60.9
Bone: trabecular spacing0.20.31.10.6-0.5-0.5-0.50.4-0.5-0.40.50.60.4-0.60.21.0-0.2-0.3
Bone: trabecular thickness0.70.82.00.6-0.8-0.8-0.81.0-1.0-0.90.80.61.1-0.60.9-0.41.01.4
Bone: trabecular tissue density3.54.96.32.4-2.5-2.4-2.42.3-2.1-2.42.42.52.1-2.42.32.11.41.2
Water consumed over 24 hours1.01.23.1-0.91.11.11.1-1.20.91.0-1.0-1.1-1.11.0-1.2-0.4-1.8-1.0
Number of responses in last shaping day1.21.21.91.3-1.2-1.2-1.11.2-1.2-1.21.21.21.1-1.01.01.40.30.2