Hub : Genes

Chmp4c

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	mRNA stability	Chmp4c	0.03	0.03	1.8e-03	0	0.01	0.01	0.01	2.1e-01	7.5e-03	1.9e-02	4.5e-02
2	Brain	gene expression	Chmp4c	0.08	0.05	1.6e-05	0.04	0.05	0.04	0.04	2.2e-04	1.9e-05	2.9e-04	2.3e-04
3	LHb	gene expression	Chmp4c	0.47	0.16	2.5e-06	0.13	0.11	0.11	0.15	5.8e-04	1.8e-03	1.2e-03	1.8e-04
4	PL	gene expression	Chmp4c	0.03	0.03	6.6e-03	0.02	0	0	0.01	5.9e-03	1.7e-01	1.1e-01	3.5e-02
5	Liver	gene expression	Chmp4c	0.04	0.03	3.0e-03	0.01	0.02	0	0.01	1.3e-02	4.2e-03	1.2e-01	3.8e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	0.2	0.4	1.2	0.4	-0.2	-0.2	0.5	1.1
Area under the delay curve	0.2	0.2	0.4	-0.4	0.0	0.3	-0.5	-0.6
BMI with tail	1.5	5.0	7.7	-2.8	-2.4	-2.3	2.1	1.3
BMI without tail	2.0	4.1	8.3	-2.9	-2.2	-1.9	1.9	0.6
Body weight	0.9	3.8	5.1	-2.2	-2.0	-2.3	1.7	1.4
Weight adjusted by age	0.2	0.3	0.4	-0.5	-0.5	-0.5	0.6	0.4
Bone surface	1.5	2.6	6.1	-0.2	-1.1	-1.6	1.8	2.5
Bone volume	1.4	2.4	5.8	-0.2	-1.1	-1.4	1.7	2.4
Breakpoint value in progressive ratio session	0.7	0.7	1.5	-1.2	-1.0	-0.7	0.7	0.4
Number of licking bursts	0.1	0.1	0.3	0.2	-0.1	-0.4	0.3	0.5
Context. condit. distance diff. score	0.4	0.4	0.6	0.4	0.6	0.7	-0.7	-0.8
Locomotion velocity, session 1	0.6	0.7	1.8	-1.3	-0.9	-0.8	0.5	0.0
Locomotion distance, session 1	1.6	2.0	2.6	-1.6	-1.5	-1.6	1.4	1.0
Locomotion velocity, session 2	0.7	0.8	2.0	-1.4	-1.1	-0.7	0.7	0.2
Locomotion distance, session 2	2.8	3.9	4.4	-2.1	-2.1	-2.0	2.0	1.6
Locomotion velocity, session 3	0.1	0.1	0.2	0.2	0.3	0.5	-0.3	-0.3
Locomotion distance, session 3	0.2	0.2	0.5	-0.2	-0.4	-0.4	0.6	0.7
Stereotopy head waving bouts, day 3	1.1	1.3	1.4	-1.1	-1.2	-1.0	1.2	1.2
Stereotopy head waving duration, day 3	0.3	0.3	0.7	-0.8	-0.7	-0.4	0.5	0.3
Locomotion velocity, session 7	2.8	3.0	6.9	-0.2	-1.2	-1.8	1.9	2.6
Locomotion distance, session 7	0.4	0.5	1.1	1.0	0.3	-0.5	0.4	1.1
Stereotopy head waving bouts, day 7	0.7	0.8	1.2	-1.1	-1.0	-0.8	0.8	0.7
Stereotopy head waving duration, day 7	0.1	0.2	0.6	-0.8	-0.4	-0.1	0.1	-0.2
Locomotion velocity, session 8	0.5	0.6	2.0	-1.4	-0.8	0.0	0.3	-0.4
Locomotion distance, session 8	0.5	0.8	1.5	-1.2	-1.0	-0.9	0.8	0.3
Degree of sensitization distance	0.0	0.0	0.1	0.3	0.1	-0.1	0.0	0.2
Degree of sensitization stereotypy	0.3	0.4	1.1	-1.1	-0.7	-0.3	0.3	0.0
Conditioned locomotion	0.1	0.1	0.2	-0.4	-0.3	-0.3	0.2	0.1
Cocaine response after cond. corrected	0.4	0.4	0.9	0.9	0.7	0.5	-0.5	-0.2
Cocaine response after cond. not corrected	0.5	0.6	1.4	1.2	0.9	0.5	-0.6	-0.2
Cocaine response before conditioning	0.1	0.1	0.3	0.0	-0.2	-0.3	0.4	0.6
Saline control response	1.2	1.6	3.2	-0.4	-1.0	-1.3	1.4	1.8
Bone: connectivity density	0.2	0.2	0.6	0.7	0.2	-0.1	0.2	0.8
Bone: cortical apparent density	0.2	0.2	0.5	-0.4	-0.0	0.6	-0.5	-0.7
Bone: cortical area	1.0	1.5	2.3	-0.9	-1.2	-1.0	1.4	1.5
Bone: cortical porosity	0.5	0.5	0.8	-0.6	-0.8	-0.6	0.8	0.9
Bone: cortical porosity	0.5	0.5	0.6	-0.7	-0.8	-0.6	0.7	0.8
Bone: cortical thickness	1.1	1.7	2.2	-1.4	-1.5	-0.9	1.4	1.4
Bone: cortical thickness	0.9	1.0	2.9	-1.7	-1.3	0.1	0.7	0.4
Bone: cortical tissue density	0.2	0.3	0.6	-0.4	0.0	0.6	-0.5	-0.7
Condit. Reinf. active minus inactive responses	7.3	8.2	11.0	-3.3	-3.2	-2.6	2.8	2.3
Condit. Reinf. active-inactive response ratio	8.5	9.2	12.9	-3.6	-3.4	-2.7	3.0	2.4
Condit. Reinf. active responses	7.2	8.8	10.9	-3.3	-3.3	-2.7	2.9	2.6
Condit. Reinf. inactive responses	0.2	0.2	0.3	-0.5	-0.5	-0.5	0.4	0.5
Incentive salience index mean	7.7	9.3	12.5	-3.5	-3.4	-2.8	3.0	2.5
Condit. Reinf. lever presses	2.7	3.6	5.1	-2.3	-2.1	-1.7	1.8	1.4
Condit. Reinf. active minus inactive responses	2.5	3.1	6.3	-0.5	-1.4	-1.7	2.0	2.5
Condit. Reinf. active-inactive response ratio	2.2	2.3	4.2	-0.7	-1.3	-1.5	1.7	2.1
Condit. Reinf. active responses	2.5	3.4	7.6	-0.4	-1.4	-1.8	2.1	2.8
Condit. Reinf. inactive responses	0.2	0.3	0.7	-0.2	-0.5	-0.5	0.6	0.8
Condit. Reinf. lever presses	1.3	1.8	3.6	-0.4	-1.1	-1.4	1.5	1.9
Condit. Reinf. lever reinforcers received	2.3	3.2	7.5	-0.3	-1.3	-1.6	2.0	2.7
Conditioned reinforcement - actives	0.3	0.3	0.7	0.8	0.2	-0.2	0.3	0.8
Conditioned reinforcement - inactives	0.0	0.0	0.1	-0.0	-0.1	-0.1	-0.2	0.3
Conditioned locomotion	0.2	0.3	0.8	0.5	-0.0	-0.4	0.3	0.9
Patch foraging indifference point 0 sec	1.0	1.7	2.2	1.5	1.4	1.4	-1.2	-0.9
Patch foraging indifference point AUC	0.2	0.2	0.5	-0.1	0.1	0.7	-0.4	-0.6
Delay disc. indifference point, 0s delay	0.1	0.1	0.2	0.4	0.4	0.3	-0.3	-0.4
Delay disc. indifference point, 16s delay	0.2	0.2	0.5	-0.3	0.1	0.5	-0.5	-0.7
Delay disc. indifference point, 2s delay	1.9	2.1	2.6	-1.5	-1.6	-1.6	1.1	1.4
Delay disc. indifference point, 24s delay	0.3	0.3	0.8	0.2	0.4	0.6	-0.9	-0.6
Delay disc. indifference point, 4s delay	0.2	0.2	0.6	-0.6	-0.1	0.4	-0.4	-0.8
Delay disc. indifference point, 8s delay	0.9	0.9	1.2	0.6	0.9	1.1	-1.0	-1.1
Indifference point function ln k	0.1	0.1	0.2	0.1	0.3	-0.2	-0.2	-0.5
Indifference point function log k	0.1	0.1	0.2	0.1	0.3	-0.2	-0.2	-0.5
Patch foraging total patch changes 0 sec	1.3	2.1	3.0	1.4	1.5	1.7	-1.4	-1.2
Patch foraging total patch changes 12 sec	1.3	1.7	2.5	1.2	1.2	1.6	-1.3	-1.0
Patch foraging total patch changes 18 sec	0.4	0.5	1.3	-0.1	0.2	1.1	-0.8	-0.8
Patch foraging total patch changes 24 sec	1.2	1.4	1.9	0.9	1.1	1.4	-1.3	-1.3
Patch foraging total patch changes 6 sec	0.8	1.2	2.6	0.7	0.9	1.6	-0.9	-1.1
Patch foraging time to switch 0 sec	2.8	4.3	5.2	-2.3	-2.3	-1.8	2.1	1.8
Patch foraging water rate 0 sec	1.1	1.8	2.6	1.2	1.4	1.2	-1.6	-1.4
Patch foraging water rate 12 sec	0.8	1.3	2.3	1.5	1.3	0.8	-1.2	-0.6
Patch foraging water rate 18 sec	0.1	0.2	0.5	0.7	0.5	0.2	-0.3	-0.0
Patch foraging water rate 24 sec	1.3	1.8	2.3	1.1	1.4	1.0	-1.5	-1.5
Patch foraging water rate 6 sec	0.8	1.2	2.4	1.5	1.2	0.8	-1.2	-0.3
Seeking ratio, delayed vs. immediate footshock	2.4	2.8	6.9	2.6	1.9	1.1	-1.5	-0.2
Distance traveled before self-admin	0.1	0.1	0.2	0.4	0.4	0.3	-0.4	-0.4
Distance traveled after self-admin	1.0	1.1	1.3	0.9	1.0	1.1	-1.1	-1.0
Extensor digitorum longus weight	3.3	13.0	30.0	-5.5	-4.1	-3.2	2.8	0.8
Bone: elastic displacement	1.7	1.9	2.3	-1.1	-1.3	-1.5	1.5	1.4
Bone: elastic work	1.5	2.0	2.6	-1.0	-1.3	-1.4	1.6	1.6
Bone: endosteal estimation	1.8	3.9	6.4	-0.9	-1.5	-2.5	2.1	2.3
Bone: endosteal perimeter	0.2	0.5	0.9	0.2	-0.3	-0.9	0.7	1.0
Epididymis fat weight	0.7	1.5	2.6	1.0	1.3	0.8	-1.3	-1.6
Delta time in closed arm before/after self-admin	0.5	0.5	0.6	0.7	0.7	0.7	-0.6	-0.7
Delta time in open arm before/after self-admin	0.0	0.0	0.1	0.2	0.2	0.3	-0.0	-0.1
Diff in mean of infusions in LGA sessions	2.2	2.4	3.5	-1.9	-1.7	-1.4	1.5	1.1
Delay discount exponential model param	0.1	0.1	0.3	0.3	0.0	-0.2	0.4	0.5
Extinction: sum of active levers before priming	0.3	0.3	0.7	-0.8	-0.6	-0.6	0.2	0.1
Active lever presses in extinction session 6	0.1	0.1	0.2	0.4	0.3	0.3	-0.0	0.0
Bone: final force	1.1	1.8	2.4	-1.1	-1.3	-1.3	1.5	1.5
Bone: final moment	0.9	1.4	2.1	-0.8	-1.1	-1.1	1.4	1.4
Food consumed during 24 hour testing period	0.8	1.0	2.2	-1.5	-1.2	-0.8	0.9	0.5
Glucose	0.5	0.8	1.8	-1.3	-1.0	-0.6	0.7	0.3
Heart weight	0.9	1.3	2.7	1.6	1.4	0.8	-0.8	-0.8
Delay discount hyperbolic model param	0.1	0.1	0.3	0.5	0.2	-0.1	0.3	0.5
Intermittent access intake day 1-15 change	3.3	3.3	5.7	2.4	2.0	1.6	-1.7	-1.0
Intermittent access intake escalation	2.4	2.4	4.2	2.0	1.7	1.4	-1.5	-0.8
Intermittent access intake escalation 2	1.8	1.7	4.1	2.0	1.5	0.9	-1.2	-0.3
Intermitt. access day 1 inactive lever presses	1.6	1.7	3.3	0.4	1.0	1.5	-1.3	-1.8
Intermitt. access day 15 inactive lever presses	3.6	3.9	5.4	1.3	1.8	2.2	-2.3	-2.1
Intermitt. access escalation Index	0.1	0.1	0.3	0.2	0.3	0.3	-0.5	-0.4
Intermittent access day 1 total infusions	0.2	0.2	0.6	0.5	0.1	-0.1	0.5	0.8
Intermittent access day 15 total infusions	1.2	1.4	4.1	2.0	1.3	0.8	-0.5	0.3
Intermittent access terminal intake (last 3 days)	1.5	1.6	4.5	2.1	1.4	1.1	-0.6	0.1
Intermittent access total infusions	0.8	0.9	2.5	1.6	1.0	0.8	-0.3	0.2
Intermittent access day 1 locomotion	0.1	0.1	0.1	0.3	0.1	0.3	-0.1	0.3
Intermittent access day 15 total locomotion	0.1	0.1	0.5	0.2	-0.1	-0.2	0.0	0.7
Intermittent access total locomotion	0.3	0.4	0.7	0.8	0.6	0.7	-0.5	0.0
Intermittent access standard deviation	5.4	5.7	7.7	2.8	2.6	2.3	-2.4	-1.7
Left kidney weight	1.1	3.1	4.6	2.1	2.0	1.7	-1.7	-1.2
Right kidney weight	1.3	3.6	4.3	2.0	2.1	2.0	-1.6	-1.8
Cocaine induced anxiety	0.6	0.7	1.3	0.3	0.6	0.9	-1.1	-0.9
Post-drug Anxiety	0.2	0.2	0.6	-0.8	-0.3	0.2	-0.1	-0.6
Baseline Anxiety	0.6	0.7	1.0	-0.7	-0.8	-0.8	1.0	0.7
Tail length	0.1	0.2	0.6	-0.8	-0.4	-0.4	0.2	-0.2
Length with tail	0.0	0.1	0.5	-0.2	-0.3	-0.7	0.1	0.4
Length without tail	0.2	0.4	1.0	0.3	-0.2	-0.8	0.1	1.0
Times rat made contact with spout	0.1	0.1	0.4	0.3	0.2	0.6	-0.2	-0.1
Lifetime Intake	1.1	1.3	3.1	1.8	1.3	1.1	-0.6	-0.1
Liver weight, left	1.1	1.7	2.8	-1.7	-1.4	-1.2	1.3	0.8
Liver weight, right	0.2	0.3	0.6	0.0	0.3	0.7	-0.8	-0.6
Locomotor activity	0.0	0.0	0.0	-0.0	-0.0	0.1	-0.1	-0.0
Locomotor testing distance	0.0	0.0	0.1	-0.2	-0.3	0.1	0.0	0.3
Locomotor testing rearing	0.3	0.5	0.9	1.0	0.7	0.9	-0.7	-0.2
Locomotion in novel chamber	0.6	0.8	1.4	-1.2	-1.1	-0.9	0.2	0.7
Locomotion in novel chamber post-restriction	0.2	0.2	0.3	0.4	0.5	0.5	-0.2	-0.5
Fecal boli incidents, locomotor time 1	0.1	0.1	0.2	-0.5	-0.3	-0.2	-0.2	0.1
Change in fecal boli incidents, locomotor task	0.4	0.4	1.1	1.0	0.6	0.1	-0.7	0.2
Time >=10cm from walls, locomotor time 1	0.3	0.3	0.9	0.3	-0.2	-0.6	-0.2	0.9
Bouts of movement, locomotor time 1	4.6	5.0	6.5	1.9	2.3	2.5	-1.9	-2.6
Total resting periods, locomotor time 1	3.1	3.4	4.2	1.6	1.9	2.0	-1.6	-2.1
Rest time, locomotor task time 1	1.6	1.8	2.1	1.3	1.5	1.4	-1.0	-1.5
Distance moved, locomotor task time 1	0.1	0.1	0.1	-0.2	-0.3	-0.3	0.2	0.3
Vertical activity count, locomotor time 1	2.0	2.1	2.7	-1.1	-1.4	-1.5	1.6	1.6
Time >=10cm from walls, locomotor time 2	1.2	1.3	2.2	-0.4	-0.9	-1.2	1.3	1.5
Bouts of movement, locomotor time 2	3.0	3.2	5.1	1.2	1.7	2.1	-1.6	-2.3
Total resting periods, locomotor time 2	3.2	3.4	5.4	1.2	1.7	2.1	-1.7	-2.3
Rest time, locomotor task time 2	0.4	0.5	1.0	0.3	0.6	0.8	-0.5	-1.0
Distance moved, locomotor task time 2	0.1	0.1	0.1	0.3	0.3	0.3	-0.2	-0.2
Vertical activity count, locomotor time 2	1.5	1.6	1.9	-1.4	-1.3	-1.3	1.4	1.0
Light reinforcement 1	0.4	0.7	1.6	-0.1	0.5	1.1	-0.8	-1.3
Light reinforcement 2	0.3	0.3	1.1	-1.1	-0.5	0.1	0.1	-0.5
Bone: marrow area	1.8	4.0	6.6	-0.9	-1.5	-2.6	2.2	2.3
Bone: maximum diameter	0.0	0.1	0.2	0.2	-0.1	-0.0	0.3	0.5
Bone: maximum force	1.4	2.4	3.2	-1.1	-1.5	-1.6	1.8	1.8
Bone: maximum moment	1.2	2.0	3.0	-0.8	-1.2	-1.4	1.6	1.7
Mean time between licks in bursts	2.2	3.2	4.0	-1.8	-1.8	-2.0	1.7	1.5
Mean num. licks in bursts	0.2	0.2	0.5	0.0	0.3	0.7	-0.5	-0.6
Cd content in liver	1.5	1.6	3.1	0.4	1.0	1.4	-1.4	-1.8
Co content in liver	1.0	1.1	2.0	0.6	1.0	1.0	-1.2	-1.4
Cu content in liver	1.8	2.2	4.4	2.1	1.7	1.4	-1.2	-0.6
Fe content in liver	3.4	4.1	6.1	-1.2	-1.8	-2.5	2.1	2.3
K content in liver	0.8	0.8	1.1	1.0	1.0	0.7	-0.9	-0.7
Mg content in liver	0.1	0.1	0.2	0.5	0.3	-0.1	-0.1	0.0
Mn content in liver	0.1	0.1	0.2	-0.3	-0.2	-0.4	0.0	-0.1
Na content in liver	0.8	0.9	1.4	1.2	1.0	0.9	-0.8	-0.6
Rb content in liver	0.1	0.2	0.3	0.3	0.4	0.3	-0.5	-0.5
Se content in liver	0.3	0.4	0.5	0.6	0.6	0.7	-0.6	-0.6
Sr content in liver	0.3	0.3	0.6	-0.8	-0.6	-0.5	0.5	0.3
Zn content in liver	1.3	1.5	2.1	1.5	1.3	1.3	-1.0	-0.8
Bone: minimum diameter	5.7	10.7	12.4	-2.7	-3.2	-3.5	3.5	3.4
Time in familiar zone, hab. session 1	2.1	2.0	2.8	1.4	1.4	1.7	-1.3	-1.3
Time in novel zone, hab. session 1	0.2	0.2	0.4	-0.4	-0.4	-0.7	0.3	0.4
Total zone transitions, hab. session 1	1.1	1.5	2.3	-1.5	-1.4	-1.0	1.2	0.9
Total locomotion distance, hab. session 1	1.6	2.3	2.7	-1.5	-1.6	-1.4	1.5	1.5
Locomotion velocity, hab. session 1	2.0	2.9	3.5	-1.8	-1.9	-1.5	1.7	1.6
Time in familiar zone, hab. session 2	4.8	4.9	5.4	2.3	2.3	2.3	-2.2	-2.0
Time in novel zone, hab. session 2	2.7	2.7	3.0	-1.5	-1.7	-1.6	1.7	1.6
Total zone transitions, hab. session 2	0.1	0.1	0.2	-0.2	0.0	0.0	-0.3	-0.5
Total locomotion distance, hab. session 2	0.3	0.5	0.5	-0.7	-0.7	-0.7	0.6	0.6
Locomotion velocity, hab. session 2	0.2	0.3	0.4	-0.6	-0.6	-0.6	0.6	0.4
Novel to familiar place preference ratio	0.6	0.6	1.2	-0.5	-0.6	-1.1	0.8	0.7
Novelty place preference	0.2	0.2	0.5	-0.2	-0.3	-0.7	0.6	0.4
Time in novel zone, NPP test	0.1	0.1	0.2	-0.1	-0.1	-0.4	0.3	0.1
Total zone transitions, NPP test	0.1	0.2	0.5	-0.7	-0.4	-0.1	0.1	-0.2
Total locomotion distance, NPP test	0.8	1.1	1.4	-1.2	-1.2	-0.9	1.0	0.9
Locomotion velocity, NPP test	0.9	1.2	1.4	-1.1	-1.2	-1.1	1.1	1.1
Intraocular pressure	1.9	2.7	4.1	-2.0	-1.8	-1.6	1.6	1.0
Delta distance traveled before/after self-admin	0.1	0.1	0.3	0.5	0.3	0.2	-0.2	0.1
Delta ambulatory time before/after self-admin	0.3	0.3	0.8	0.9	0.7	0.5	-0.4	-0.1
Parametrial fat weight	0.1	0.1	0.4	-0.1	0.2	-0.1	-0.4	-0.6
Pavlov. Cond. lever latency	0.7	0.9	1.4	1.2	1.1	0.7	-0.9	-0.8
Pavlov. Cond. magazine entry latency	0.7	0.9	1.1	-1.0	-1.0	-0.8	1.0	0.8
Pavlov. Cond. change in total contacts	2.3	2.4	4.0	-2.0	-1.8	-1.4	1.4	1.1
Pavlov. Cond. index score	0.5	0.6	1.2	-1.1	-1.0	-0.5	0.7	0.5
Pavlov. Cond. latency score	0.4	0.5	1.0	-1.0	-0.8	-0.4	0.6	0.4
Pavlov. Cond. lever contacts	1.6	1.9	2.3	-1.5	-1.5	-1.2	1.4	1.2
Pavlov. Cond. magazine entry number	0.3	0.4	1.0	1.0	0.8	0.4	-0.5	-0.3
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.2	0.3	0.1	-0.4	0.1	0.4
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	1.2	-1.1	-0.9	-0.5	0.7	0.5
Pavlov. Cond. response bias	1.2	1.5	2.0	-1.4	-1.4	-1.1	1.2	1.0
Pavlov. Cond. lever latency	0.2	0.2	0.7	-0.8	-0.4	-0.4	0.2	-0.3
Pavlov. Cond. magazine entry latency	0.1	0.1	0.1	-0.1	-0.2	-0.4	0.3	0.3
Pavlov. Cond. change in total contacts	2.2	3.1	4.5	-1.2	-1.7	-1.8	1.9	2.1
Pavlov. Cond. index score	0.8	1.0	1.8	-0.5	-0.9	-1.0	1.1	1.4
Pavlov. Cond. latency score	0.4	0.5	1.1	-0.2	-0.6	-0.7	0.8	1.1
Pavlov. Cond. lever contacts	0.1	0.1	0.4	0.4	0.0	-0.0	0.2	0.6
Pavlov. Cond. magazine entry number	0.3	0.4	0.6	0.5	0.6	0.8	-0.7	-0.7
Pavlov. Cond. intertrial magazine entries	0.6	0.7	0.9	-0.9	-0.9	-1.0	0.9	0.7
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	1.5	-0.4	-0.7	-0.9	1.0	1.2
Pavlov. Cond. response bias	0.6	0.8	1.6	-0.3	-0.7	-0.9	1.0	1.3
Time in closed arm before self-admin	0.5	0.5	0.7	0.8	0.8	0.8	-0.7	-0.5
Time in closed arm after self-admin	1.7	1.7	1.9	1.2	1.3	1.4	-1.4	-1.2
Time in open arm before self-admin	1.3	1.5	2.0	-0.9	-1.2	-1.3	1.2	1.4
Time in open arm after self-admin	0.6	0.7	1.2	-1.1	-0.9	-0.6	0.8	0.5
Bone: periosteal estimation	2.8	5.8	7.8	-1.5	-2.1	-2.7	2.7	2.8
Bone: periosteal perimeter	0.4	0.6	1.3	-0.2	-0.5	-0.8	0.9	1.1
Bone: post-yield work	0.6	0.8	2.3	1.5	1.0	0.6	-0.4	0.2
Progressive ratio test 1 active lever presses	4.3	4.5	5.7	2.4	2.3	2.4	-1.7	-1.7
Progressive ratio test 1 breakpoint	3.5	3.7	4.9	2.2	2.1	2.2	-1.5	-1.4
Progressive ratio test 1 inactive lever presses	1.2	1.3	2.2	0.9	1.1	1.5	-1.0	-1.2
Progressive ratio test 2 active lever presses	0.5	0.6	1.7	1.3	0.8	0.6	-0.2	0.2
Progressive ratio test 2 breakpoint	0.3	0.3	1.1	1.1	0.6	0.3	0.1	0.4
Progressive ratio test 2 inactive lever presses	0.5	0.6	1.2	1.1	0.8	0.7	-0.7	0.0
Incentive Sensitization - Responses	1.3	1.3	2.8	-0.2	-0.8	-1.3	1.3	1.7
Incentive Sensitization - Breakpoint	1.0	1.0	2.2	-0.0	-0.6	-1.1	1.1	1.5
Sum of active levers in priming session hrs 5-6	0.7	0.6	1.0	-0.4	-0.7	-1.0	0.8	1.0
Progressive ratio	3.1	3.6	6.8	1.7	1.8	1.7	-2.6	-1.5
Food seeking constrained by brief footshock	3.1	3.8	5.9	-2.4	-2.2	-2.0	1.5	1.5
Seeking ratio, punishment vs. effort	6.0	7.3	9.9	-2.9	-2.8	-2.5	3.1	2.0
Retroperitoneal fat weight	0.0	0.1	0.2	0.4	0.5	0.0	-0.3	-0.4
Reaction time number correct	0.7	1.0	1.9	-0.5	-0.9	-1.2	0.8	1.4
Reaction time mean minus median	0.5	0.6	1.1	-0.7	-0.0	1.0	-0.7	-1.1
Reaction time mean minus median AUC	0.4	0.5	1.3	-1.1	-0.5	0.7	-0.1	-0.6
Reaction time num false alarms	1.3	1.8	3.6	-0.4	-1.0	-1.4	1.5	1.9
Reaction time num false alarms AUC	0.9	1.2	2.8	-0.3	-0.8	-1.1	1.2	1.7
Reaction time trials correct on left	0.7	1.0	1.9	-0.5	-0.9	-1.2	0.8	1.4
Reaction time trials on left	0.8	1.1	1.9	-0.6	-0.9	-1.2	0.9	1.4
Reaction time mean	0.4	0.6	1.8	-1.4	-1.0	-0.3	0.4	0.1
Reaction time mean AUC	0.6	0.8	2.3	-1.5	-1.1	-0.4	0.7	0.3
Median of all reaction times	0.9	1.3	2.6	-1.6	-1.3	-0.9	0.9	0.6
Reaction time omissions	0.5	0.7	2.2	-1.5	-0.8	0.5	0.1	-0.5
Reaction time false alarm rate	0.0	0.0	0.1	0.2	0.0	-0.0	0.3	0.3
Reaction time premature initiation rate	1.6	2.2	3.4	1.8	1.7	1.4	-1.3	-1.1
Reaction time premature initiations	0.7	1.0	2.0	1.4	1.1	0.8	-0.9	-0.3
Std. dev. reaction times	0.3	0.4	0.7	-0.6	-0.1	0.8	-0.5	-0.8
Reaction time trials completed	0.8	1.1	1.9	-0.6	-0.9	-1.2	0.9	1.4
Reaction time trials AUC	0.9	1.3	2.1	-0.7	-1.1	-1.3	1.0	1.5
Run reversals in cocaine runway, females	0.3	0.3	0.9	-0.5	-0.3	-0.0	-0.9	-0.2
Run reversals in cocaine runway, males	2.5	2.4	3.8	-2.0	-1.7	-1.5	1.5	0.9
Latency to leave start box in cocaine runway	0.1	0.1	0.3	0.6	0.3	-0.2	0.1	0.2
Latency to leave start box in cocaine runway, F	0.4	0.5	1.7	1.3	0.8	0.0	-0.1	0.2
Latency to leave start box in cocaine runway, M	0.7	0.7	1.6	-1.3	-0.9	-0.6	0.7	0.2
Std. dev. time between licks in bursts	0.6	0.8	1.3	-0.6	-0.8	-1.1	0.9	0.9
Total sessions with >9 infusions	1.7	1.9	2.7	1.5	1.5	1.6	-1.0	-1.1
Short access day 1 total inactive lever presses	1.1	1.3	1.7	1.1	1.2	1.3	-1.0	-1.0
Short access day 10 total inactive lever presses	1.3	1.5	2.3	0.7	1.1	1.2	-1.3	-1.5
Short access day 1 total infusions	2.0	2.1	3.1	1.8	1.6	1.4	-1.4	-1.0
Short access day 10 total infusions	1.8	2.0	3.2	1.8	1.5	1.5	-1.3	-0.7
Short access total infusions	1.6	1.8	3.2	1.8	1.5	1.5	-1.0	-0.6
Short access day 1 locomotion	1.1	1.2	2.1	1.0	1.1	1.4	-0.9	-1.0
Short access day 10 total locomotion	0.5	0.5	1.0	-0.2	0.2	0.9	-1.0	-0.9
Short access total locomotion	0.7	0.8	1.3	0.9	0.8	1.2	-0.9	-0.6
One hour access (0.3 mA shock)	0.5	0.6	2.0	1.4	0.7	0.1	-0.1	0.7
Compulsive drug intake	0.5	0.6	1.1	-0.9	-0.7	-0.6	1.1	-0.0
One hour access (shock baseline)	1.6	1.9	4.9	2.2	1.4	0.9	-1.3	0.3
Social response proportion	0.2	0.2	0.4	0.1	0.3	0.6	-0.5	-0.7
Social responses	0.4	0.5	1.1	-0.0	0.4	1.1	-0.7	-1.0
Social time	0.1	0.1	0.2	-0.1	-0.2	0.2	0.3	0.4
Soleus weight	0.3	0.7	1.8	-1.3	-1.0	-0.4	0.8	0.2
Bone: stiffness	0.3	0.5	0.6	-0.6	-0.7	-0.7	0.8	0.8
Tibialis anterior weight	4.2	14.2	26.9	-5.2	-4.2	-3.6	3.2	1.7
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.4	0.3	-0.1	-0.3	0.5	0.6
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.8	0.9	0.4	0.2	0.1	0.4
Time to tail flick, test, before self-admin	1.7	1.6	2.0	0.9	1.2	1.4	-1.4	-1.4
Time to tail flick, test, after self-admin	1.0	1.1	1.4	1.2	1.1	1.1	-1.0	-0.7
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.4	0.6	0.3	0.1	0.0	0.3
Delta time to tail flick, test, before/after SA	0.4	0.3	0.4	0.5	0.6	0.6	-0.5	-0.6
Tibia length	0.5	1.4	3.4	1.9	1.5	0.4	-0.8	-0.5
Ambulatory time before self-admin	0.1	0.1	0.1	0.3	0.3	0.2	0.2	-0.4
Ambulatory time after self-admin	0.3	0.3	0.5	0.7	0.6	0.4	-0.6	-0.3
Bone: tissue strength	1.5	1.4	2.6	1.6	1.4	1.1	-1.0	-0.6
Total heroin consumption	0.6	0.7	0.7	-0.8	-0.8	-0.8	0.8	0.8
Bone: trabecular number	0.1	0.1	0.3	0.5	0.1	0.2	0.1	0.6
Bone: trabecular spacing	0.2	0.2	0.8	-0.3	0.1	0.2	-0.5	-0.9
Bone: trabecular thickness	0.6	0.7	2.3	0.1	-0.5	-0.3	0.9	1.5
Bone: trabecular tissue density	0.3	0.4	0.9	-0.7	-0.1	0.8	-0.4	-0.9
Water consumed over 24 hours	0.0	0.1	0.1	-0.3	-0.3	-0.1	0.2	0.1
Number of responses in last shaping day	0.6	0.6	1.0	0.6	0.7	1.0	-0.7	-0.7