Hub : Genes

Chmp4c

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	mRNA stability	Chmp4c	0.04	0.03	5.6e-04	0	0.02	0.02	0.01	7.7e-02	1.5e-03	5.2e-03	7.9e-03
2	Liver	gene expression	Chmp4c	0.04	0.03	3.4e-03	0.02	0.02	0	0.01	1.8e-03	4.7e-03	1.0e-01	2.0e-02
3	Brain	gene expression	Chmp4c	0.07	0.05	8.1e-05	0.01	0.04	0.03	0.02	4.2e-02	2.4e-04	1.2e-03	2.7e-03
4	LHb	gene expression	Chmp4c	0.45	0.18	5.9e-05	0.09	0.05	0.08	0.1	4.5e-03	2.9e-02	5.7e-03	2.6e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.8	1.4	2.8	0.3	1.7	-0.2	-1.6
Area under the delay curve	0.5	0.6	1.2	-0.2	-1.1	0.1	1.0
BMI with tail	0.3	1.1	1.5	-1.2	-1.1	-0.9	0.9
BMI without tail	0.5	1.4	2.6	-1.6	-0.9	-1.3	0.7
Body weight	0.6	2.8	6.0	-2.5	-0.4	-2.2	0.2
Weight adjusted by age	0.2	0.3	0.7	-0.8	0.3	-0.8	-0.3
Bone surface	2.6	4.8	9.1	-0.2	3.0	-0.9	-3.0
Bone volume	2.6	4.6	8.6	-0.3	2.9	-1.1	-2.9
Breakpoint value in progressive ratio session	0.4	0.5	1.1	-1.1	0.0	-1.0	-0.1
Number of licking bursts	0.2	0.3	0.6	0.2	0.8	0.0	-0.7
Context. condit. distance diff. score	0.2	0.2	0.3	0.3	-0.5	0.5	0.6
Locomotion velocity, session 1	1.0	1.1	2.0	-1.4	-0.8	-1.1	0.7
Locomotion distance, session 1	0.9	1.2	2.5	-1.6	0.0	-1.5	-0.2
Locomotion velocity, session 2	0.9	1.1	2.0	-1.4	-0.8	-1.1	0.6
Locomotion distance, session 2	1.6	2.3	4.4	-2.1	0.3	-2.1	-0.5
Locomotion velocity, session 3	0.1	0.1	0.2	0.1	-0.4	0.2	0.4
Locomotion distance, session 3	0.3	0.3	0.6	-0.1	0.8	-0.3	-0.8
Stereotopy head waving bouts, day 3	0.9	1.1	1.4	-1.0	1.0	-1.2	-1.0
Stereotopy head waving duration, day 3	0.2	0.3	0.6	-0.8	-0.1	-0.7	-0.0
Locomotion velocity, session 7	5.2	5.7	11.0	-0.1	3.3	-0.9	-3.3
Locomotion distance, session 7	2.3	2.9	5.2	1.2	2.3	0.6	-2.2
Stereotopy head waving bouts, day 7	0.5	0.5	1.1	-1.1	-0.3	-1.0	0.2
Stereotopy head waving duration, day 7	0.6	0.7	0.8	-0.9	-0.9	-0.6	0.8
Locomotion velocity, session 8	1.5	1.8	2.3	-1.5	-1.5	-1.0	1.4
Locomotion distance, session 8	0.5	0.7	1.6	-1.3	-0.4	-1.0	0.3
Degree of sensitization distance	0.2	0.2	0.3	0.4	0.6	0.3	-0.5
Degree of sensitization stereotypy	0.8	0.9	1.4	-1.2	-0.9	-0.9	0.8
Conditioned locomotion	0.1	0.1	0.2	-0.4	-0.2	-0.3	0.1
Cocaine response after cond. corrected	0.3	0.4	0.8	0.9	0.4	0.8	-0.3
Cocaine response after cond. not corrected	0.6	0.7	1.3	1.2	0.6	0.9	-0.5
Cocaine response before conditioning	0.3	0.3	0.6	0.0	0.8	-0.2	-0.8
Saline control response	1.1	1.4	2.4	-0.6	1.5	-0.9	-1.5
Bone: connectivity density	0.8	1.2	2.2	0.7	1.5	0.2	-1.4
Bone: cortical apparent density	0.6	0.8	1.5	-0.5	-1.2	-0.2	1.1
Bone: cortical area	0.9	1.4	1.9	-1.2	1.0	-1.4	-1.1
Bone: cortical porosity	0.2	0.3	0.4	-0.3	0.6	-0.5	-0.6
Bone: cortical porosity	0.3	0.3	0.5	-0.6	0.5	-0.7	-0.5
Bone: cortical thickness	1.0	1.6	2.8	-1.6	0.6	-1.7	-0.8
Bone: cortical thickness	1.6	1.9	3.7	-1.9	-1.0	-1.6	0.8
Bone: cortical tissue density	0.6	0.8	1.6	-0.5	-1.3	-0.1	1.2
Condit. Reinf. active minus inactive responses	5.0	5.5	10.9	-3.3	0.5	-3.2	-0.8
Condit. Reinf. active-inactive response ratio	5.9	6.3	12.6	-3.6	0.5	-3.4	-0.7
Condit. Reinf. active responses	4.7	5.9	10.8	-3.3	0.9	-3.3	-1.1
Condit. Reinf. inactive responses	0.1	0.1	0.2	-0.4	0.2	-0.5	-0.3
Incentive salience index mean	5.1	6.3	12.4	-3.5	0.5	-3.5	-0.8
Condit. Reinf. lever presses	1.8	2.6	5.5	-2.3	-0.1	-2.2	-0.1
Condit. Reinf. active minus inactive responses	3.4	4.5	8.1	-0.5	2.8	-1.2	-2.8
Condit. Reinf. active-inactive response ratio	2.7	3.1	5.3	-0.7	2.3	-1.2	-2.3
Condit. Reinf. active responses	3.9	5.4	10.1	-0.4	3.2	-1.2	-3.2
Condit. Reinf. inactive responses	0.2	0.3	0.5	-0.2	0.7	-0.4	-0.7
Condit. Reinf. lever presses	2.0	2.7	5.0	-0.3	2.2	-0.9	-2.2
Condit. Reinf. lever reinforcers received	3.8	5.3	10.0	-0.3	3.2	-1.1	-3.2
Conditioned reinforcement - actives	1.9	3.2	6.3	0.9	2.5	0.1	-2.4
Conditioned reinforcement - inactives	0.4	0.5	1.0	-0.1	1.0	-0.3	-1.0
Conditioned locomotion	1.0	1.3	2.5	0.5	1.6	-0.1	-1.6
Patch foraging indifference point 0 sec	0.5	0.9	2.0	1.4	0.1	1.3	0.1
Patch foraging indifference point AUC	0.2	0.2	0.5	-0.1	-0.7	0.1	0.7
Delay disc. indifference point, 0s delay	0.2	0.2	0.3	0.5	-0.4	0.5	0.5
Delay disc. indifference point, 16s delay	0.2	0.2	0.4	-0.2	-0.6	0.1	0.6
Delay disc. indifference point, 2s delay	1.3	1.4	2.6	-1.6	0.5	-1.6	-0.6
Delay disc. indifference point, 24s delay	0.1	0.1	0.1	0.1	-0.3	0.2	0.3
Delay disc. indifference point, 4s delay	1.2	1.2	2.4	-0.5	-1.5	-0.1	1.5
Delay disc. indifference point, 8s delay	0.6	0.7	0.9	0.6	-1.0	0.8	1.0
Indifference point function ln k	0.0	0.0	0.1	0.1	-0.2	0.2	0.2
Indifference point function log k	0.0	0.0	0.1	0.1	-0.2	0.2	0.2
Patch foraging total patch changes 0 sec	0.5	0.9	1.8	1.3	-0.2	1.3	0.3
Patch foraging total patch changes 12 sec	0.6	0.7	1.1	1.0	-0.6	1.0	0.7
Patch foraging total patch changes 18 sec	0.2	0.2	0.5	-0.2	-0.7	0.0	0.7
Patch foraging total patch changes 24 sec	0.4	0.7	0.9	0.7	-0.9	0.9	0.9
Patch foraging total patch changes 6 sec	0.3	0.4	0.5	0.5	-0.7	0.7	0.7
Patch foraging time to switch 0 sec	1.5	3.1	5.4	-2.3	0.8	-2.3	-1.0
Patch foraging water rate 0 sec	0.6	1.3	1.9	1.2	-0.9	1.4	1.0
Patch foraging water rate 12 sec	0.6	1.2	2.4	1.5	0.7	1.3	-0.6
Patch foraging water rate 18 sec	0.1	0.2	0.3	0.6	0.4	0.4	-0.3
Patch foraging water rate 24 sec	0.9	1.2	1.7	1.1	-0.9	1.3	1.0
Patch foraging water rate 6 sec	0.9	1.4	2.4	1.5	0.9	1.2	-0.8
Seeking ratio, delayed vs. immediate footshock	3.0	3.6	6.9	2.6	1.4	2.0	-1.2
Distance traveled before self-admin	0.3	0.5	0.8	-0.5	-0.9	-0.3	0.8
Distance traveled after self-admin	0.1	0.1	0.2	0.4	0.0	0.4	0.0
Extensor digitorum longus weight	4.2	16.7	31.7	-5.6	-3.0	-4.4	2.6
Bone: elastic displacement	1.3	1.5	1.7	-1.1	1.2	-1.3	-1.2
Bone: elastic work	1.3	1.7	1.9	-1.1	1.3	-1.4	-1.4
Bone: endosteal estimation	1.4	3.2	5.3	-0.7	2.3	-1.2	-2.3
Bone: endosteal perimeter	0.4	0.9	1.9	0.2	1.4	-0.1	-1.3
Epididymis fat weight	0.3	1.0	2.0	-0.5	-1.4	-0.1	1.4
Delta time in closed arm before/after self-admin	0.9	0.8	1.1	0.7	-1.0	0.8	1.1
Delta time in open arm before/after self-admin	0.3	0.3	0.5	0.1	0.7	-0.0	-0.7
Diff in mean of infusions in LGA sessions	1.8	2.2	3.7	-1.9	0.9	-1.9	-0.9
Delay discount exponential model param	0.5	0.5	1.0	0.1	1.0	-0.2	-1.0
Extinction: sum of active levers before priming	0.3	0.3	0.5	-0.6	0.3	-0.7	-0.3
Active lever presses in extinction session 6	0.3	0.3	0.5	0.7	-0.3	0.7	0.4
Bone: final force	1.0	1.5	2.3	-1.3	1.0	-1.5	-1.1
Bone: final moment	0.9	1.5	1.7	-1.0	1.2	-1.3	-1.3
Food consumed during 24 hour testing period	0.8	1.1	2.5	-1.6	-0.3	-1.4	0.2
Glucose	0.5	0.7	1.5	-1.2	-0.5	-1.0	0.4
Heart weight	0.4	0.6	1.2	0.0	-1.1	0.3	1.0
Delay discount hyperbolic model param	0.4	0.5	0.8	0.5	0.9	0.2	-0.9
Intermittent access intake day 1-15 change	0.8	1.7	2.9	1.7	1.2	1.3	-0.9
Intermittent access intake escalation	1.0	2.1	4.2	2.1	0.9	1.7	-0.7
Intermittent access intake escalation 2	2.4	2.7	4.3	2.1	1.6	1.5	-1.3
Intermitt. access day 1 inactive lever presses	0.5	1.8	3.5	-0.1	-1.9	0.4	1.9
Intermitt. access day 15 inactive lever presses	1.0	2.1	3.0	1.0	-1.6	1.4	1.7
Intermitt. access escalation Index	0.8	1.1	2.0	0.4	-1.3	0.8	1.4
Intermittent access day 1 total infusions	1.4	2.2	4.3	0.7	2.1	0.1	-2.0
Intermittent access day 15 total infusions	2.8	4.2	5.2	2.3	2.3	1.6	-2.0
Intermittent access terminal intake (last 3 days)	3.6	4.7	6.2	2.3	2.5	1.5	-2.2
Intermittent access total infusions	2.3	2.7	3.8	1.7	2.0	1.0	-1.8
Intermittent access day 1 locomotion	0.7	0.8	1.6	0.5	1.3	0.3	-1.2
Intermittent access day 15 total locomotion	0.5	1.0	2.0	0.3	1.4	-0.1	-1.4
Intermittent access total locomotion	1.1	1.3	2.2	0.9	1.5	0.5	-1.4
Intermittent access standard deviation	1.4	2.9	6.3	2.5	0.7	2.1	-0.5
Left kidney weight	0.2	0.7	1.2	1.0	-0.6	1.1	0.6
Right kidney weight	0.0	0.2	0.4	-0.0	-0.6	0.2	0.6
Cocaine induced anxiety	0.2	0.3	0.6	-0.1	-0.8	0.2	0.7
Post-drug Anxiety	0.8	0.8	1.4	-1.2	-0.8	-0.9	0.6
Baseline Anxiety	0.5	0.6	1.1	-1.0	0.3	-1.0	-0.3
Tail length	0.3	1.0	2.3	-1.5	-0.1	-1.3	0.0
Length with tail	0.4	1.7	3.3	-1.8	0.4	-1.8	-0.5
Length without tail	0.2	0.7	1.0	-0.6	0.9	-0.8	-1.0
Times rat made contact with spout	0.0	0.0	0.1	0.3	0.1	0.2	-0.0
Lifetime Intake	1.8	2.1	3.6	1.9	1.3	1.4	-1.1
Liver weight, left	0.4	0.7	1.3	-1.1	0.2	-1.1	-0.3
Liver weight, right	0.6	1.1	1.7	0.6	-1.2	0.8	1.3
Locomotor activity	0.0	0.0	0.0	-0.1	0.0	-0.1	-0.0
Locomotor testing distance	0.1	0.2	0.2	-0.4	0.4	-0.4	-0.4
Locomotor testing rearing	0.2	0.5	0.9	1.0	0.5	0.7	-0.4
Locomotion in novel chamber	0.7	0.9	1.8	-1.3	0.0	-1.3	-0.1
Locomotion in novel chamber post-restriction	0.2	0.3	0.6	0.3	-0.8	0.5	0.6
Fecal boli incidents, locomotor time 1	0.0	0.1	0.1	-0.4	-0.1	-0.3	0.1
Change in fecal boli incidents, locomotor task	0.8	0.8	1.6	1.3	0.7	0.9	-0.5
Time >=10cm from walls, locomotor time 1	0.4	0.4	0.8	0.4	0.9	0.1	-0.8
Bouts of movement, locomotor time 1	4.3	4.8	5.8	1.8	-2.3	2.2	2.4
Total resting periods, locomotor time 1	3.1	3.4	4.1	1.6	-1.9	1.9	2.0
Rest time, locomotor task time 1	0.9	1.1	1.5	0.9	-1.1	1.0	1.2
Distance moved, locomotor task time 1	0.1	0.2	0.2	-0.3	0.5	-0.3	-0.5
Vertical activity count, locomotor time 1	0.7	1.7	2.2	-1.1	1.4	-1.3	-1.5
Time >=10cm from walls, locomotor time 2	0.6	0.9	1.8	-0.3	1.3	-0.6	-1.2
Bouts of movement, locomotor time 2	2.4	3.9	6.1	1.1	-2.5	1.5	2.5
Total resting periods, locomotor time 2	2.5	4.4	6.8	1.1	-2.6	1.6	2.6
Rest time, locomotor task time 2	0.8	1.0	1.8	0.4	-1.3	0.7	1.3
Distance moved, locomotor task time 2	0.0	0.0	0.1	0.2	0.1	0.2	-0.0
Vertical activity count, locomotor time 2	0.8	1.1	2.2	-1.5	0.3	-1.4	-0.5
Light reinforcement 1	0.6	1.5	3.1	-0.1	-1.8	0.3	1.7
Light reinforcement 2	0.8	1.3	1.8	-1.2	-1.3	-0.7	1.2
Bone: marrow area	1.4	3.2	5.1	-0.8	2.2	-1.3	-2.3
Bone: maximum diameter	0.1	0.1	0.2	-0.0	0.4	-0.1	-0.4
Bone: maximum force	1.1	1.9	2.7	-1.4	1.2	-1.6	-1.3
Bone: maximum moment	1.1	1.9	2.4	-1.0	1.5	-1.4	-1.5
Mean time between licks in bursts	0.7	1.8	3.1	-1.7	0.7	-1.8	-0.9
Mean num. licks in bursts	0.2	0.3	0.5	0.0	-0.7	0.2	0.7
Cd content in liver	1.0	1.2	2.2	0.3	-1.5	0.6	1.4
Co content in liver	1.7	2.0	2.6	1.0	-1.6	1.3	1.6
Cu content in liver	1.5	1.8	4.0	2.0	0.2	1.8	-0.0
Fe content in liver	0.4	0.4	0.8	0.0	0.9	-0.3	-0.9
K content in liver	0.5	0.5	1.0	1.0	-0.0	1.0	0.1
Mg content in liver	0.3	0.3	0.5	0.7	0.4	0.6	-0.3
Mn content in liver	0.0	0.0	0.0	0.1	-0.1	0.2	0.1
Na content in liver	0.7	0.7	1.5	1.2	0.3	1.1	-0.2
Rb content in liver	0.2	0.2	0.3	0.5	-0.4	0.5	0.5
Se content in liver	0.2	0.3	0.5	0.5	-0.4	0.7	0.4
Sr content in liver	0.5	0.5	0.6	-0.7	0.6	-0.7	-0.7
Zn content in liver	1.7	1.8	3.9	2.0	0.5	1.8	-0.3
Bone: minimum diameter	4.2	7.7	9.5	-2.6	2.6	-3.1	-2.8
Time in familiar zone, hab. session 1	1.4	1.4	2.1	1.3	-0.9	1.4	0.9
Time in novel zone, hab. session 1	0.2	0.2	0.2	-0.4	0.5	-0.4	-0.5
Total zone transitions, hab. session 1	0.8	1.1	2.4	-1.6	-0.3	-1.4	0.1
Total locomotion distance, hab. session 1	1.1	1.5	2.5	-1.5	0.8	-1.6	-0.9
Locomotion velocity, hab. session 1	1.3	1.9	3.5	-1.8	0.6	-1.9	-0.7
Time in familiar zone, hab. session 2	3.1	3.3	5.2	2.2	-1.1	2.3	1.3
Time in novel zone, hab. session 2	2.1	2.1	2.7	-1.5	1.3	-1.6	-1.4
Total zone transitions, hab. session 2	0.4	0.5	1.1	-0.3	-1.1	-0.0	1.0
Total locomotion distance, hab. session 2	0.2	0.3	0.5	-0.7	0.1	-0.7	-0.1
Locomotion velocity, hab. session 2	0.1	0.2	0.3	-0.6	-0.0	-0.6	-0.1
Novel to familiar place preference ratio	0.4	0.4	0.6	-0.5	0.7	-0.6	-0.8
Novelty place preference	0.2	0.2	0.4	-0.2	0.6	-0.2	-0.6
Time in novel zone, NPP test	0.1	0.1	0.1	-0.0	0.4	-0.0	-0.3
Total zone transitions, NPP test	0.6	0.8	1.3	-0.8	-1.2	-0.5	1.0
Total locomotion distance, NPP test	0.5	0.7	1.4	-1.2	0.1	-1.2	-0.2
Locomotion velocity, NPP test	0.5	0.7	1.4	-1.1	0.4	-1.2	-0.5
Intraocular pressure	1.4	2.1	4.3	-2.1	-0.5	-1.9	0.3
Delta distance traveled before/after self-admin	2.0	2.1	3.6	1.1	1.9	0.7	-1.7
Delta ambulatory time before/after self-admin	1.7	2.1	3.4	1.2	1.8	0.8	-1.7
Parametrial fat weight	0.1	0.3	0.5	-0.7	0.2	-0.7	-0.2
Pavlov. Cond. lever latency	0.5	0.6	1.3	1.1	-0.1	1.1	0.2
Pavlov. Cond. magazine entry latency	0.4	0.5	1.0	-1.0	0.2	-1.0	-0.3
Pavlov. Cond. change in total contacts	1.7	1.8	4.0	-2.0	-0.1	-1.8	-0.1
Pavlov. Cond. index score	0.5	0.6	1.2	-1.1	-0.3	-1.0	0.2
Pavlov. Cond. latency score	0.4	0.5	1.0	-1.0	-0.4	-0.9	0.3
Pavlov. Cond. lever contacts	1.0	1.2	2.3	-1.5	0.5	-1.5	-0.6
Pavlov. Cond. magazine entry number	0.4	0.5	1.1	1.0	0.4	0.9	-0.4
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.4	0.3	0.6	0.1	-0.6
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	1.1	-1.1	-0.3	-1.0	0.2
Pavlov. Cond. response bias	0.9	1.1	2.1	-1.5	0.2	-1.4	-0.3
Pavlov. Cond. lever latency	0.6	0.9	1.4	-0.8	-1.2	-0.5	1.1
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	-0.1	0.1	-0.1	-0.1
Pavlov. Cond. change in total contacts	1.8	2.9	4.2	-1.2	2.0	-1.5	-2.0
Pavlov. Cond. index score	0.8	1.1	1.8	-0.5	1.3	-0.8	-1.3
Pavlov. Cond. latency score	0.6	0.8	1.5	-0.2	1.2	-0.5	-1.2
Pavlov. Cond. lever contacts	0.5	0.7	1.3	0.4	1.2	0.1	-1.1
Pavlov. Cond. magazine entry number	0.2	0.2	0.3	0.4	-0.4	0.5	0.4
Pavlov. Cond. intertrial magazine entries	0.3	0.5	0.9	-0.9	0.4	-1.0	-0.4
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.9	1.6	-0.4	1.2	-0.7	-1.2
Pavlov. Cond. response bias	0.8	1.0	1.9	-0.3	1.4	-0.6	-1.4
Time in closed arm before self-admin	0.6	0.7	1.4	1.2	0.4	1.1	-0.3
Time in closed arm after self-admin	1.6	1.8	2.5	1.4	-1.1	1.6	1.2
Time in open arm before self-admin	0.5	0.6	0.8	-0.7	0.7	-0.9	-0.7
Time in open arm after self-admin	0.4	0.5	0.9	-0.9	0.2	-0.9	-0.3
Bone: periosteal estimation	2.2	4.7	5.8	-1.7	2.3	-2.2	-2.4
Bone: periosteal perimeter	0.4	0.7	1.3	-0.3	1.1	-0.5	-1.1
Bone: post-yield work	1.3	1.9	2.9	1.7	1.3	1.2	-1.2
Progressive ratio test 1 active lever presses	0.9	1.1	2.2	1.5	0.6	1.3	-0.4
Progressive ratio test 1 breakpoint	0.9	1.1	2.1	1.4	0.7	1.2	-0.5
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.0	0.0	0.1	0.0	-0.0
Progressive ratio test 2 active lever presses	1.9	2.2	3.8	1.2	2.0	0.5	-1.8
Progressive ratio test 2 breakpoint	1.9	2.1	3.7	1.2	1.9	0.5	-1.8
Progressive ratio test 2 inactive lever presses	0.5	0.8	1.1	0.9	1.0	0.6	-1.0
Incentive Sensitization - Responses	2.1	2.9	5.6	-0.0	2.4	-0.7	-2.4
Incentive Sensitization - Breakpoint	2.1	2.7	5.3	0.1	2.3	-0.6	-2.3
Sum of active levers in priming session hrs 5-6	1.2	1.1	2.2	-0.2	1.4	-0.5	-1.5
Progressive ratio	1.6	2.5	3.7	1.8	-1.2	1.9	1.3
Food seeking constrained by brief footshock	2.4	3.0	6.2	-2.5	0.2	-2.4	-0.4
Seeking ratio, punishment vs. effort	2.9	4.2	7.6	-2.8	0.9	-2.7	-1.0
Retroperitoneal fat weight	0.1	0.4	0.6	-0.8	-0.7	-0.6	0.6
Reaction time number correct	0.8	1.5	2.6	-0.4	1.6	-0.8	-1.6
Reaction time mean minus median	0.8	2.0	3.9	-0.8	-2.0	-0.3	1.9
Reaction time mean minus median AUC	0.7	1.8	2.9	-1.2	-1.7	-0.7	1.5
Reaction time num false alarms	1.8	2.5	4.7	-0.2	2.2	-0.7	-2.2
Reaction time num false alarms AUC	1.4	2.1	4.1	-0.0	2.0	-0.6	-2.0
Reaction time trials correct on left	0.8	1.5	2.6	-0.4	1.6	-0.8	-1.6
Reaction time trials on left	0.8	1.5	2.5	-0.5	1.6	-0.9	-1.6
Reaction time mean	0.7	1.1	1.9	-1.4	-0.9	-1.1	0.8
Reaction time mean AUC	0.8	1.2	2.3	-1.5	-0.8	-1.3	0.6
Median of all reaction times	0.8	1.1	2.4	-1.6	-0.3	-1.4	0.1
Reaction time omissions	1.6	2.3	3.4	-1.8	-1.5	-1.3	1.4
Reaction time false alarm rate	0.1	0.1	0.2	0.4	0.5	0.2	-0.4
Reaction time premature initiation rate	1.2	1.7	3.4	1.8	-0.4	1.8	0.5
Reaction time premature initiations	0.5	1.0	2.2	1.5	0.3	1.2	-0.2
Std. dev. reaction times	0.6	1.1	2.1	-0.6	-1.4	-0.2	1.4
Reaction time trials completed	0.8	1.5	2.5	-0.5	1.6	-0.9	-1.6
Reaction time trials AUC	0.8	1.6	2.6	-0.6	1.6	-1.0	-1.6
Run reversals in cocaine runway, females	0.2	0.2	0.3	-0.5	-0.3	-0.4	0.3
Run reversals in cocaine runway, males	1.4	1.4	3.1	-1.8	-0.1	-1.6	0.0
Latency to leave start box in cocaine runway	0.3	0.3	0.6	0.8	0.4	0.6	-0.4
Latency to leave start box in cocaine runway, F	1.1	1.2	2.1	1.5	1.0	1.1	-0.8
Latency to leave start box in cocaine runway, M	1.0	0.9	1.4	-1.2	-1.0	-0.9	0.8
Std. dev. time between licks in bursts	0.4	0.5	0.6	-0.6	0.8	-0.7	-0.8
Total sessions with >9 infusions	1.2	1.4	3.1	1.8	0.3	1.6	-0.1
Short access day 1 total inactive lever presses	1.6	2.1	3.7	1.9	-0.7	1.9	0.8
Short access day 10 total inactive lever presses	0.5	1.3	2.2	0.4	-1.5	0.7	1.5
Short access day 1 total infusions	1.4	1.8	3.9	2.0	-0.1	1.8	0.2
Short access day 10 total infusions	1.1	1.4	2.3	1.5	1.0	1.2	-0.8
Short access total infusions	0.9	1.1	2.4	1.6	0.5	1.3	-0.4
Short access day 1 locomotion	0.4	0.5	0.9	0.9	-0.3	1.0	0.3
Short access day 10 total locomotion	0.1	0.2	0.4	-0.1	-0.6	0.1	0.6
Short access total locomotion	0.3	0.3	0.6	0.8	0.4	0.7	-0.3
One hour access (0.3 mA shock)	2.6	3.0	5.5	1.2	2.4	0.5	-2.2
Compulsive drug intake	0.3	0.3	0.6	-0.5	-0.8	-0.2	0.7
One hour access (shock baseline)	3.5	5.4	9.6	1.7	3.1	0.7	-2.9
Social response proportion	0.3	0.3	0.6	0.0	-0.8	0.2	0.8
Social responses	0.6	0.8	1.6	-0.0	-1.3	0.3	1.3
Social time	0.0	0.0	0.1	-0.2	0.2	-0.2	-0.2
Soleus weight	0.4	1.1	2.4	-1.5	-0.5	-1.3	0.4
Bone: stiffness	0.3	0.5	0.9	-0.9	0.5	-0.9	-0.6
Tibialis anterior weight	4.0	13.4	28.8	-5.4	-1.7	-4.5	1.2
Time to tail flick, vehicle, before self-admin	0.4	0.4	0.8	-0.0	0.9	-0.3	-0.9
Time to tail flick, vehicle, after self-admin	0.9	1.2	1.8	1.3	1.1	1.0	-0.9
Time to tail flick, test, before self-admin	0.6	0.6	0.7	0.7	-0.8	0.9	0.8
Time to tail flick, test, after self-admin	0.8	0.9	1.9	1.4	0.3	1.2	-0.2
Delta time to tail flick, vehicle, before/after SA	1.0	1.0	1.8	1.4	0.8	1.0	-0.6
Delta time to tail flick, test, before/after SA	0.1	0.1	0.1	0.2	-0.2	0.3	0.3
Tibia length	0.6	1.5	3.2	1.8	0.6	1.6	-0.4
Ambulatory time before self-admin	0.5	0.8	1.1	-0.9	-1.0	-0.6	1.0
Ambulatory time after self-admin	0.4	0.4	0.9	0.1	0.9	-0.1	-0.9
Bone: tissue strength	1.4	1.4	3.1	1.7	0.4	1.5	-0.3
Total heroin consumption	0.9	1.0	1.7	-0.6	1.2	-0.8	-1.3
Bone: trabecular number	0.2	0.3	0.6	0.4	0.8	0.1	-0.8
Bone: trabecular spacing	0.8	1.1	2.1	-0.3	-1.5	0.1	1.4
Bone: trabecular thickness	1.8	2.2	4.3	0.0	2.1	-0.5	-2.1
Bone: trabecular tissue density	1.3	1.9	3.5	-1.0	-1.9	-0.5	1.8
Water consumed over 24 hours	0.1	0.1	0.1	-0.4	-0.2	-0.3	0.2
Number of responses in last shaping day	0.3	0.4	0.8	0.9	0.2	0.8	-0.2