Hub : Genes

Morc3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL isoform ratio XM_063270585.1 0.03 0.02 1.6e-03 0.02 0.02 0.03 0.03 1.0e-03 6.9e-03 2.8e-04 8.7e-04
2 Adipose isoform ratio XM_063270588.1 0.04 0.03 3.0e-03 0.02 0.01 0.01 0.01 6.2e-03 7.9e-03 1.0e-02 1.3e-02
3 Eye isoform ratio XM_063270584.1 0.42 0.18 1.2e-03 0.07 0.03 0.06 0.07 2.9e-02 1.1e-01 3.8e-02 3.6e-02
4 PL intron excision ratio chr11_46632835_46633662 0.03 0.02 3.6e-03 0 0.01 0.01 0 1.4e-01 3.8e-02 9.9e-03 7.8e-02
5 Liver isoform ratio XM_039088415.2 0.02 0.01 9.2e-03 0 0.01 0 0 1.4e-01 2.7e-02 2.8e-01 1.3e-01
6 LHb isoform ratio XM_039088415.2 0.15 0.1 6.3e-03 0.01 0.02 0.01 -0 2.2e-01 1.3e-01 2.1e-01 3.5e-01
7 Adipose isoform ratio XM_039088415.2 0.03 0.02 9.4e-04 0 0.01 0.01 0 2.6e-01 3.0e-02 4.6e-02 8.7e-02
8 Adipose mRNA stability Morc3 0.08 0.04 2.9e-09 0.06 0.07 0.06 0.07 1.7e-07 9.6e-09 4.9e-07 3.3e-08
9 pVTA mRNA stability Morc3 0.07 0.04 7.4e-05 0.04 0.04 0.05 0.06 5.8e-04 2.8e-04 5.2e-05 2.0e-05
10 Adipose gene expression Morc3 0.12 0.07 4.1e-09 0.07 0.08 0.08 0.09 2.2e-08 1.5e-09 1.5e-09 9.8e-10
11 Liver gene expression Morc3 0.1 0.05 4.1e-09 0.04 0.07 0.05 0.06 5.4e-05 5.1e-08 1.5e-06 3.7e-07
12 Brain gene expression Morc3 0.08 0.05 1.3e-05 0.01 0.04 0.03 0.04 2.2e-02 6.4e-05 6.7e-04 2.1e-04
13 NAcc gene expression Morc3 0.04 0.02 2.1e-04 0.01 0.02 0.03 0.02 1.7e-03 1.3e-04 7.3e-05 3.7e-04
14 Liver isoform ratio NM_001395628.1 0.02 0.02 8.2e-03 0.01 -0 0 0 2.6e-02 5.2e-01 1.9e-01 2.8e-01
15 PL intron excision ratio chr11_46642820_46648103 0.04 0.03 8.1e-03 -0 0.01 -0 -0 4.7e-01 5.5e-02 4.3e-01 3.8e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.20.40.90.4-0.30.5-0.9-0.6-0.6-0.00.60.20.50.50.90.90.90.3
Area under the delay curve0.81.03.8-0.4-0.5-0.3-0.2-0.4-0.60.51.0-0.10.91.51.20.51.82.0
BMI with tail0.62.24.62.2-1.31.1-1.8-1.6-1.7-0.91.7-0.8-0.21.61.61.91.41.2
BMI without tail0.20.51.60.5-0.20.1-1.0-0.5-0.60.30.70.41.00.71.10.91.30.6
Body weight0.10.20.80.9-0.3-0.4-0.2-0.2-0.40.10.5-0.10.20.70.30.10.60.8
Weight adjusted by age0.50.71.6-0.90.6-1.31.01.10.91.2-0.80.70.6-0.3-0.7-1.1-0.10.2
Bone surface4.17.512.83.6-3.23.0-2.6-3.1-3.0-3.03.0-3.0-2.32.72.22.41.11.9
Bone volume2.54.47.12.7-2.52.2-2.2-2.4-2.4-2.22.3-2.1-1.42.01.92.01.21.4
Breakpoint value in progressive ratio session0.20.21.3-0.1-0.20.40.5-0.1-0.1-0.70.0-0.7-1.10.0-0.40.0-0.60.0
Number of licking bursts0.30.52.4-0.80.6-0.8-0.30.40.31.1-0.31.11.5-0.30.30.30.7-0.1
Context. condit. distance diff. score0.30.41.10.3-0.8-0.40.80.20.1-0.30.1-0.9-0.80.6-0.6-0.6-0.51.1
Locomotion velocity, session 10.10.10.3-0.10.20.1-0.00.00.1-0.2-0.20.0-0.2-0.4-0.3-0.4-0.5-0.5
Locomotion distance, session 10.40.62.40.6-0.90.80.0-0.4-0.4-1.00.4-1.3-1.60.5-0.3-0.0-0.60.4
Locomotion velocity, session 20.20.30.70.8-0.70.20.1-0.1-0.1-0.60.0-0.7-0.80.1-0.6-0.6-0.80.0
Locomotion distance, session 20.10.10.7-0.0-0.4-0.1-0.1-0.1-0.20.10.4-0.4-0.10.70.1-0.00.30.8
Locomotion velocity, session 32.32.67.32.2-1.62.1-0.7-1.5-1.2-2.60.9-2.3-2.70.4-0.10.4-1.3-0.4
Locomotion distance, session 30.60.61.70.6-0.51.1-0.8-1.0-1.0-0.80.9-0.6-0.50.60.91.30.50.2
Stereotopy head waving bouts, day 31.01.28.10.20.91.1-0.9-0.20.2-0.6-0.80.6-0.1-1.9-0.4-0.2-1.4-2.8
Stereotopy head waving duration, day 30.70.85.00.40.61.0-0.7-0.20.0-0.7-0.60.3-0.2-1.4-0.3-0.4-1.2-2.2
Locomotion velocity, session 71.11.22.4-1.61.1-1.21.11.31.21.2-1.21.00.9-0.9-1.0-1.2-0.5-0.5
Locomotion distance, session 70.70.82.6-1.50.7-1.30.91.10.91.6-0.60.91.00.0-0.5-0.20.50.7
Stereotopy head waving bouts, day 71.31.43.91.8-0.81.3-0.6-0.8-0.4-2.00.1-1.3-1.8-0.6-0.6-0.5-1.7-1.3
Stereotopy head waving duration, day 71.51.85.12.1-1.21.1-0.2-0.7-0.5-2.20.2-1.8-2.3-0.2-0.8-1.1-1.8-0.7
Locomotion velocity, session 81.92.35.62.4-1.91.8-0.9-1.4-1.2-2.31.0-2.0-2.30.6-0.0-0.1-1.1-0.1
Locomotion distance, session 80.30.52.20.3-0.9-0.30.60.0-0.1-0.30.4-1.1-0.81.0-0.4-0.5-0.11.5
Degree of sensitization distance1.11.22.3-1.30.7-1.51.21.51.31.5-1.10.90.8-0.5-1.1-1.1-0.30.1
Degree of sensitization stereotypy1.82.05.62.4-1.61.4-0.7-1.2-1.0-2.30.9-2.1-2.20.6-0.0-0.1-0.90.1
Conditioned locomotion0.70.91.2-1.10.9-1.11.01.11.10.9-1.10.80.5-0.9-0.9-1.0-0.6-0.6
Cocaine response after cond. corrected0.60.72.00.00.1-0.31.20.70.7-0.2-0.7-0.4-1.1-0.6-1.3-1.2-1.4-0.4
Cocaine response after cond. not corrected0.60.82.1-0.10.1-0.61.40.90.90.0-0.8-0.4-1.0-0.5-1.4-1.3-1.4-0.2
Cocaine response before conditioning0.10.10.70.0-0.5-0.10.1-0.0-0.20.10.3-0.4-0.00.60.20.20.40.8
Saline control response0.91.33.61.5-1.41.4-0.6-0.9-0.8-1.60.7-1.8-1.90.50.10.5-0.60.2
Bone: connectivity density1.11.72.51.5-1.21.4-1.4-1.5-1.6-1.01.5-0.9-0.51.31.51.51.20.9
Bone: cortical apparent density0.00.00.0-0.10.1-0.10.0-0.0-0.00.00.00.10.10.10.10.00.20.1
Bone: cortical area0.50.72.51.2-0.80.10.40.00.1-1.0-0.1-1.2-1.6-0.1-1.0-0.9-1.3-0.1
Bone: cortical porosity0.40.51.3-1.10.7-0.80.40.70.61.0-0.50.81.0-0.3-0.0-0.30.30.1
Bone: cortical porosity0.40.41.1-1.00.7-0.80.60.80.71.0-0.60.60.7-0.4-0.3-0.40.10.0
Bone: cortical thickness2.23.68.6-1.21.3-2.12.52.22.31.1-2.10.9-0.1-1.7-2.5-2.9-2.1-1.1
Bone: cortical thickness0.50.61.1-1.10.9-1.01.00.80.90.7-0.80.70.6-0.6-0.6-1.0-0.3-0.3
Bone: cortical tissue density0.00.00.1-0.10.1-0.0-0.1-0.1-0.10.10.10.10.20.10.20.20.30.1
Condit. Reinf. active minus inactive responses0.10.10.2-0.40.3-0.10.20.20.20.1-0.30.20.1-0.3-0.1-0.5-0.1-0.2
Condit. Reinf. active-inactive response ratio0.40.40.7-0.70.6-0.50.60.70.80.4-0.80.40.0-0.8-0.8-0.7-0.7-0.7
Condit. Reinf. active responses0.00.00.2-0.30.20.00.30.00.0-0.10.0-0.1-0.10.10.1-0.40.10.3
Condit. Reinf. inactive responses0.00.00.10.00.10.30.3-0.2-0.1-0.30.1-0.2-0.30.10.0-0.2-0.10.0
Incentive salience index mean0.10.10.5-0.70.4-0.40.40.40.40.4-0.30.30.3-0.2-0.2-0.6-0.00.1
Condit. Reinf. lever presses0.20.31.1-0.80.4-0.70.90.60.60.5-0.40.30.2-0.1-0.6-1.0-0.30.2
Condit. Reinf. active minus inactive responses0.91.13.11.0-1.70.5-0.0-0.8-0.8-1.21.0-1.8-1.51.40.20.10.11.5
Condit. Reinf. active-inactive response ratio0.60.72.60.2-1.00.0-0.3-0.6-0.7-0.21.0-0.70.01.30.90.61.11.6
Condit. Reinf. active responses1.11.54.81.7-1.71.2-0.1-0.8-0.8-1.80.7-2.0-2.20.6-0.3-0.2-1.00.3
Condit. Reinf. inactive responses1.11.44.72.0-1.31.3-0.2-0.5-0.4-1.70.1-1.5-2.2-0.2-0.9-0.3-1.7-0.7
Condit. Reinf. lever presses0.70.92.71.3-1.40.9-0.4-0.8-0.7-1.50.6-1.5-1.60.5-0.10.1-0.70.2
Condit. Reinf. lever reinforcers received1.31.85.21.8-1.91.3-0.3-1.0-0.9-1.90.9-2.2-2.30.8-0.20.1-0.90.5
Conditioned reinforcement - actives0.71.24.2-1.50.8-2.01.51.31.11.5-0.80.90.8-0.2-0.7-0.80.20.6
Conditioned reinforcement - inactives4.26.29.3-2.93.1-2.63.12.93.01.9-2.91.60.4-2.6-2.8-2.4-1.9-1.7
Conditioned locomotion0.50.62.1-1.50.4-0.80.80.91.00.5-1.00.2-0.2-0.9-0.80.3-0.6-0.7
Patch foraging indifference point 0 sec1.83.37.5-0.70.6-1.52.12.12.20.8-2.20.7-0.4-2.1-2.7-2.5-2.5-1.7
Patch foraging indifference point AUC0.91.34.21.8-1.41.2-0.2-0.6-0.5-1.60.5-1.7-2.10.5-0.4-0.5-1.00.2
Delay disc. indifference point, 0s delay0.90.93.60.2-0.70.1-0.4-0.7-0.9-0.01.2-0.50.61.61.10.51.51.9
Delay disc. indifference point, 16s delay0.30.41.4-0.5-0.0-0.1-0.6-0.2-0.30.50.40.40.90.50.90.71.20.6
Delay disc. indifference point, 2s delay0.80.92.90.1-0.30.0-0.6-0.7-0.90.11.20.00.91.41.30.31.71.6
Delay disc. indifference point, 24s delay0.40.51.4-1.20.5-0.90.80.70.51.0-0.30.50.50.2-0.0-0.40.60.8
Delay disc. indifference point, 4s delay1.21.33.90.6-1.30.4-0.7-0.8-1.00.01.3-0.60.41.81.21.21.62.0
Delay disc. indifference point, 8s delay0.40.41.7-0.70.0-1.00.50.30.10.80.20.10.80.70.2-0.50.81.3
Indifference point function ln k0.81.44.7-2.21.5-1.51.31.21.21.5-1.01.21.1-0.7-0.5-0.60.1-0.1
Indifference point function log k0.81.44.7-2.21.5-1.51.31.21.21.5-1.01.21.1-0.7-0.5-0.60.1-0.1
Patch foraging total patch changes 0 sec1.42.76.5-0.40.3-1.31.91.81.90.5-2.00.4-0.6-1.8-2.6-2.3-2.4-1.5
Patch foraging total patch changes 12 sec0.91.23.81.3-0.90.90.2-0.00.2-1.3-0.4-1.2-1.9-0.7-1.2-0.9-1.9-1.0
Patch foraging total patch changes 18 sec0.71.03.21.2-1.00.40.50.10.3-1.1-0.4-1.2-1.8-0.4-1.3-1.1-1.7-0.6
Patch foraging total patch changes 24 sec0.50.83.11.1-1.20.40.3-0.2-0.1-1.10.2-1.6-1.80.4-0.6-0.7-0.90.5
Patch foraging total patch changes 6 sec1.42.27.90.9-0.30.21.10.71.0-1.0-1.3-0.7-2.0-1.6-2.1-1.8-2.8-1.9
Patch foraging time to switch 0 sec0.30.51.50.1-0.10.3-0.8-0.6-0.70.30.70.30.90.71.11.21.20.5
Patch foraging water rate 0 sec0.40.93.41.2-0.60.9-0.2-0.6-0.3-1.60.1-1.0-1.8-0.3-0.4-0.1-1.3-0.8
Patch foraging water rate 12 sec0.81.74.1-0.90.9-2.01.91.71.61.1-1.50.70.1-1.0-1.8-1.2-1.2-0.4
Patch foraging water rate 18 sec0.20.30.80.10.00.4-0.5-0.7-0.7-0.40.7-0.10.00.50.90.80.70.4
Patch foraging water rate 24 sec0.30.41.7-0.40.2-1.21.30.60.50.4-0.2-0.2-0.50.3-0.5-0.4-0.10.9
Patch foraging water rate 6 sec0.10.20.8-0.60.2-0.60.90.40.40.0-0.3-0.2-0.5-0.1-0.5-0.2-0.40.2
Seeking ratio, delayed vs. immediate footshock0.81.04.4-0.91.5-0.3-0.3-0.1-0.11.10.11.82.1-0.11.1-0.31.4-0.2
Distance traveled before self-admin0.20.31.4-0.20.30.40.3-0.00.1-0.6-0.3-0.4-1.2-0.4-0.50.5-0.9-0.6
Distance traveled after self-admin0.70.82.30.2-0.50.3-1.2-0.8-1.00.21.00.10.91.11.40.91.51.0
Extensor digitorum longus weight3.313.021.84.5-3.64.7-4.3-4.3-4.1-4.13.6-3.3-2.62.63.34.11.41.0
Bone: elastic displacement0.60.71.6-1.11.3-0.60.70.70.70.9-0.81.20.9-0.9-0.2-0.6-0.1-0.8
Bone: elastic work0.20.30.9-0.40.7-0.10.30.30.50.1-0.60.4-0.1-0.8-0.4-0.7-0.6-0.9
Bone: endosteal estimation3.67.910.63.2-3.13.0-3.2-3.2-3.3-2.73.2-2.7-1.62.82.72.91.82.0
Bone: endosteal perimeter2.04.38.52.9-2.82.0-1.6-2.0-2.0-2.42.0-2.8-2.32.01.01.60.31.6
Epididymis fat weight0.61.94.81.8-2.20.9-0.4-1.0-1.1-1.51.3-2.2-1.91.60.30.5-0.11.6
Delta time in closed arm before/after self-admin1.81.74.40.8-1.20.2-1.7-0.9-1.10.41.30.21.51.41.71.52.11.4
Delta time in open arm before/after self-admin0.10.10.5-0.20.20.70.1-0.4-0.3-0.60.2-0.2-0.4-0.00.1-0.2-0.2-0.2
Diff in mean of infusions in LGA sessions0.81.04.60.7-0.51.10.4-0.4-0.2-1.70.0-1.7-2.2-0.1-0.7-0.3-1.5-0.4
Delay discount exponential model param0.70.83.20.40.40.30.20.30.6-0.5-0.90.0-0.8-1.4-1.1-0.4-1.7-1.8
Extinction: sum of active levers before priming0.60.73.00.5-1.10.10.50.30.4-0.8-0.4-1.1-1.7-0.2-1.1-0.2-1.3-0.2
Active lever presses in extinction session 62.32.26.4-0.50.6-0.21.21.31.6-0.0-1.90.5-1.0-2.3-2.1-0.8-2.5-2.5
Bone: final force0.40.62.21.2-1.10.7-0.4-0.5-0.4-1.10.3-1.2-1.50.2-0.3-0.0-0.70.0
Bone: final moment0.40.62.51.2-1.10.7-0.4-0.4-0.3-1.10.3-1.2-1.60.2-0.3-0.0-0.8-0.0
Food consumed during 24 hour testing period0.60.81.6-0.50.6-1.01.01.11.10.6-1.10.60.2-0.9-1.3-1.0-1.1-0.7
Glucose3.75.913.13.6-3.03.0-2.4-2.6-2.4-3.22.1-3.1-2.71.61.21.4-0.20.6
Heart weight0.20.41.5-0.00.10.0-0.7-0.5-0.50.20.60.30.70.61.10.31.20.7
Delay discount hyperbolic model param0.80.93.60.20.50.20.20.40.7-0.4-1.00.1-0.8-1.5-1.1-0.4-1.7-1.9
Intermittent access intake day 1-15 change0.91.93.3-1.71.8-1.01.51.51.60.9-1.71.10.4-1.7-1.4-0.8-1.4-1.5
Intermittent access intake escalation0.91.83.1-1.71.8-0.91.41.41.51.0-1.61.20.6-1.7-1.2-0.9-1.2-1.5
Intermittent access intake escalation 20.80.92.4-0.80.7-0.31.30.81.0-0.0-1.10.0-0.8-1.2-1.2-0.6-1.5-1.2
Intermitt. access day 1 inactive lever presses0.83.04.8-2.21.6-2.01.82.12.11.9-2.01.51.1-1.6-1.7-1.8-1.0-0.9
Intermitt. access day 15 inactive lever presses1.22.55.2-1.71.6-1.02.31.61.80.3-1.80.1-1.3-1.7-2.1-1.2-2.1-1.3
Intermitt. access escalation Index0.20.30.8-0.90.8-0.60.30.60.60.7-0.50.60.8-0.3-0.2-0.70.0-0.1
Intermittent access day 1 total infusions0.91.53.6-1.61.4-1.91.71.51.51.2-1.20.80.2-0.8-1.2-1.0-0.3-0.0
Intermittent access day 15 total infusions3.75.510.2-3.23.1-2.42.92.72.81.9-2.71.70.3-2.4-2.4-1.4-1.6-1.7
Intermittent access terminal intake (last 3 days)3.54.79.4-3.12.8-2.33.02.52.61.8-2.41.30.1-2.0-2.2-1.5-1.4-1.2
Intermittent access total infusions3.23.86.8-2.52.6-2.32.52.32.31.7-2.21.40.3-1.8-1.9-1.5-1.1-1.1
Intermittent access day 1 locomotion1.92.55.5-2.31.3-2.41.82.01.92.0-1.51.21.0-0.9-1.3-1.5-0.10.1
Intermittent access day 15 total locomotion1.22.35.5-1.20.7-1.51.91.82.00.5-1.9-0.2-1.3-1.6-2.3-0.8-1.9-1.0
Intermittent access total locomotion4.04.88.7-2.71.8-2.72.92.82.81.7-2.60.7-0.3-2.0-2.8-1.8-1.8-1.1
Intermittent access standard deviation0.71.53.5-0.51.2-0.31.21.01.20.0-1.40.2-0.8-1.6-1.7-1.3-1.9-1.7
Left kidney weight1.35.915.5-3.22.8-3.92.82.72.43.5-1.72.72.6-0.5-1.0-1.31.01.0
Right kidney weight1.46.213.8-2.82.7-3.73.13.02.83.2-2.32.62.0-1.4-2.0-2.3-0.2-0.0
Cocaine induced anxiety0.20.41.0-0.30.6-0.40.80.70.70.1-0.70.1-0.4-0.6-1.0-0.6-0.8-0.5
Post-drug Anxiety0.50.52.30.8-1.00.30.3-0.1-0.2-0.80.3-1.4-1.50.6-0.60.1-0.50.7
Baseline Anxiety0.60.72.30.5-1.0-0.0-0.5-0.7-0.90.11.1-0.30.41.41.00.71.21.5
Tail length1.45.49.6-3.12.4-2.42.82.72.72.1-2.62.01.0-2.2-2.2-2.7-1.4-1.4
Length with tail0.31.43.1-1.51.0-1.71.81.41.41.1-1.10.80.3-0.7-1.3-1.6-0.5-0.0
Length without tail0.10.21.20.6-0.4-0.00.4-0.1-0.0-0.60.1-0.8-1.10.2-0.4-0.2-0.50.2
Times rat made contact with spout8.59.813.7-3.73.6-3.43.53.73.73.2-3.52.91.9-3.0-3.0-2.9-1.9-2.0
Lifetime Intake1.92.34.9-2.12.2-1.91.71.71.71.6-1.61.50.9-1.4-1.1-1.0-0.3-0.8
Liver weight, left3.96.411.1-3.33.0-3.32.32.82.73.2-2.43.12.8-1.8-1.4-2.4-0.1-0.8
Liver weight, right2.03.47.7-2.32.2-2.21.01.91.72.6-1.62.72.8-1.4-0.7-0.90.3-0.9
Locomotor activity1.42.34.4-1.71.0-2.12.12.01.72.1-1.41.21.4-0.6-1.5-1.4-0.30.3
Locomotor testing distance0.81.42.6-0.90.7-1.61.41.61.51.4-1.40.90.8-0.9-1.5-1.3-0.8-0.5
Locomotor testing rearing0.20.41.0-0.60.1-1.00.80.70.61.0-0.30.40.90.1-0.4-0.30.30.6
Locomotion in novel chamber0.30.30.7-0.70.7-0.40.80.50.60.1-0.60.1-0.7-0.5-0.60.8-0.6-0.3
Locomotion in novel chamber post-restriction0.30.51.80.1-0.10.7-1.3-0.8-0.7-0.40.60.11.00.21.00.40.7-0.2
Fecal boli incidents, locomotor time 10.50.73.8-0.3-0.6-0.70.0-0.2-0.40.30.8-0.3-0.31.40.71.01.22.0
Change in fecal boli incidents, locomotor task2.42.35.4-2.31.9-1.31.41.71.61.8-1.61.61.4-1.4-1.0-1.5-0.4-1.0
Time >=10cm from walls, locomotor time 10.80.83.2-0.60.4-0.80.60.91.00.4-1.00.20.3-1.0-1.1-1.8-1.1-0.9
Bouts of movement, locomotor time 10.10.10.40.1-0.20.5-0.1-0.2-0.1-0.40.1-0.2-0.5-0.0-0.00.6-0.3-0.2
Total resting periods, locomotor time 10.10.10.50.0-0.40.40.0-0.1-0.0-0.40.0-0.4-0.7-0.0-0.20.7-0.4-0.1
Rest time, locomotor task time 11.82.36.50.9-1.80.7-0.6-1.1-1.4-0.71.7-1.6-1.32.31.11.81.42.5
Distance moved, locomotor task time 11.21.85.2-1.12.0-0.3-0.00.81.00.9-1.31.82.0-2.0-0.4-1.1-0.6-2.3
Vertical activity count, locomotor time 10.30.73.00.40.50.1-0.50.30.5-0.2-0.80.60.7-1.3-0.7-1.3-1.1-1.7
Time >=10cm from walls, locomotor time 20.30.41.20.6-0.40.9-1.1-0.8-0.8-0.50.6-0.10.30.20.90.80.5-0.2
Bouts of movement, locomotor time 21.32.15.51.5-1.81.3-0.4-1.3-1.3-1.81.4-2.3-2.11.60.60.10.11.5
Total resting periods, locomotor time 20.61.13.40.8-1.40.70.2-0.6-0.6-1.10.8-1.9-1.81.20.1-0.3-0.11.3
Rest time, locomotor task time 20.40.51.5-0.0-0.9-0.61.00.60.50.0-0.3-0.9-1.20.2-1.0-0.6-0.70.7
Distance moved, locomotor task time 20.81.03.3-0.31.10.6-1.4-0.7-0.60.20.31.11.8-0.41.41.01.1-0.9
Vertical activity count, locomotor time 20.70.93.60.9-0.50.9-1.9-1.2-1.2-0.71.0-0.10.90.51.30.40.9-0.1
Light reinforcement 10.41.02.10.8-1.10.5-0.7-0.9-1.0-0.31.2-0.6-0.11.41.11.11.31.5
Light reinforcement 23.85.88.12.6-2.62.8-1.9-2.7-2.7-2.62.7-2.6-2.12.62.02.41.22.0
Bone: marrow area3.98.511.33.4-3.23.1-3.3-3.3-3.4-2.83.3-2.9-1.82.92.73.01.82.1
Bone: maximum diameter1.12.15.02.2-2.01.3-0.7-1.2-1.1-2.01.1-2.2-2.21.00.10.4-0.60.7
Bone: maximum force0.30.51.61.3-0.90.9-0.7-0.6-0.5-1.10.3-0.9-1.20.0-0.10.4-0.6-0.4
Bone: maximum moment0.30.51.51.2-0.90.8-0.6-0.5-0.4-1.10.3-1.0-1.20.1-0.10.3-0.6-0.2
Mean time between licks in bursts0.92.34.0-1.92.0-1.61.41.71.62.0-1.61.91.4-1.3-1.1-0.9-0.3-0.9
Mean num. licks in bursts1.52.34.6-1.11.5-1.02.21.61.70.5-1.80.5-0.6-1.6-2.1-1.8-2.0-1.3
Cd content in liver0.70.82.20.7-0.11.3-1.5-1.2-1.1-0.60.80.10.30.31.31.30.9-0.3
Co content in liver0.50.62.00.4-0.60.1-0.3-0.6-0.7-0.21.0-0.50.11.20.90.51.11.4
Cu content in liver0.30.30.6-0.60.4-0.70.50.70.80.5-0.80.50.3-0.7-0.6-0.5-0.5-0.5
Fe content in liver0.91.13.6-0.10.4-0.10.60.60.9-0.4-1.20.0-0.9-1.5-1.3-1.4-1.9-1.7
K content in liver0.40.40.80.6-0.60.6-0.7-0.7-0.8-0.40.7-0.20.20.60.80.90.70.4
Mg content in liver0.60.61.10.6-0.60.7-0.9-0.9-0.9-0.50.9-0.40.10.81.10.80.90.6
Mn content in liver0.60.71.50.8-1.20.6-0.6-0.8-0.8-0.71.0-1.0-0.61.20.60.60.61.2
Na content in liver3.03.26.12.5-2.22.1-1.3-1.9-1.7-2.41.6-2.4-2.21.40.81.2-0.10.8
Rb content in liver0.30.30.9-0.60.5-0.90.20.50.40.9-0.30.80.9-0.10.1-0.40.50.2
Se content in liver1.01.22.6-0.80.9-0.70.31.01.20.7-1.31.00.6-1.6-1.0-1.4-1.1-1.6
Sr content in liver0.70.61.4-1.20.8-1.10.90.90.81.1-0.60.91.0-0.3-0.3-0.20.20.2
Zn content in liver0.00.00.10.1-0.1-0.0-0.20.10.10.1-0.20.20.1-0.3-0.1-0.1-0.2-0.4
Bone: minimum diameter3.36.011.93.4-2.83.1-2.5-2.7-2.6-3.12.4-2.9-2.51.81.51.90.20.9
Time in familiar zone, hab. session 10.30.31.10.6-0.90.00.1-0.1-0.2-0.20.4-0.7-0.60.8-0.00.50.31.1
Time in novel zone, hab. session 10.60.61.5-0.30.60.9-1.2-0.7-0.6-0.10.30.60.8-0.41.11.00.6-1.0
Total zone transitions, hab. session 10.60.92.2-0.80.5-1.51.41.31.11.1-0.80.30.2-0.1-1.2-1.2-0.40.6
Total locomotion distance, hab. session 10.81.12.1-1.20.9-1.41.31.41.21.4-1.00.90.7-0.5-1.0-1.3-0.20.0
Locomotion velocity, hab. session 10.91.22.2-1.21.0-1.51.31.41.21.5-1.11.00.8-0.6-1.0-1.4-0.3-0.0
Time in familiar zone, hab. session 21.31.33.60.8-1.20.8-0.5-1.0-1.2-0.71.4-1.3-0.71.71.10.81.21.9
Time in novel zone, hab. session 20.80.82.2-1.01.1-0.60.00.70.80.7-1.01.31.0-1.3-0.4-0.1-0.5-1.5
Total zone transitions, hab. session 20.40.53.0-0.3-0.3-0.90.90.50.20.70.2-0.40.01.0-0.4-0.50.41.7
Total locomotion distance, hab. session 20.81.13.0-1.30.6-1.71.11.10.81.7-0.40.71.20.4-0.4-0.80.81.3
Locomotion velocity, hab. session 20.71.02.7-1.10.5-1.61.01.10.81.6-0.40.71.10.5-0.4-0.70.71.3
Novel to familiar place preference ratio0.30.30.9-0.40.40.1-0.8-0.1-0.10.5-0.10.80.9-0.40.40.80.5-0.7
Novelty place preference0.40.51.5-0.10.10.4-1.2-0.5-0.50.30.30.71.0-0.10.91.20.9-0.4
Time in novel zone, NPP test0.50.51.8-0.1-0.00.6-1.3-0.6-0.70.10.50.50.80.11.11.31.0-0.2
Total zone transitions, NPP test0.20.30.9-0.1-0.4-0.30.80.20.1-0.10.1-0.8-0.80.5-0.5-0.6-0.30.9
Total locomotion distance, NPP test0.10.20.5-0.70.4-0.60.20.40.20.7-0.10.40.50.1-0.0-0.00.40.4
Locomotion velocity, NPP test0.20.20.7-0.70.4-0.80.30.50.40.9-0.30.50.60.0-0.2-0.10.30.3
Intraocular pressure0.20.30.8-0.50.70.6-0.7-0.4-0.30.20.10.80.8-0.20.90.70.7-0.5
Delta distance traveled before/after self-admin2.32.47.80.4-1.2-0.1-1.5-0.9-1.30.71.70.12.02.22.10.42.82.5
Delta ambulatory time before/after self-admin2.12.67.80.8-1.5-0.2-1.4-0.9-1.40.71.8-0.01.82.42.00.52.82.7
Parametrial fat weight4.19.615.64.0-3.43.0-4.0-3.6-3.8-2.33.7-1.8-0.53.23.43.12.62.1
Pavlov. Cond. lever latency0.10.10.30.4-0.30.0-0.5-0.3-0.30.10.30.00.30.30.40.60.50.2
Pavlov. Cond. magazine entry latency0.40.61.5-1.20.9-0.70.50.80.80.9-0.70.90.9-0.7-0.4-0.7-0.1-0.5
Pavlov. Cond. change in total contacts0.10.10.9-0.20.1-0.40.40.20.20.1-0.00.20.30.1-0.1-1.00.10.3
Pavlov. Cond. index score0.10.10.2-0.50.4-0.20.30.40.40.3-0.40.40.2-0.3-0.3-0.4-0.2-0.3
Pavlov. Cond. latency score0.10.10.3-0.60.4-0.30.30.40.40.4-0.40.50.3-0.3-0.3-0.5-0.1-0.2
Pavlov. Cond. lever contacts0.20.20.7-0.10.10.10.50.30.4-0.2-0.4-0.2-0.6-0.4-0.7-0.6-0.8-0.4
Pavlov. Cond. magazine entry number0.20.20.70.8-0.60.30.1-0.3-0.3-0.60.3-0.7-0.70.4-0.1-0.0-0.20.3
Pavlov. Cond. intertrial magazine entries1.61.95.81.4-0.62.2-0.9-1.3-0.8-2.40.3-1.5-2.3-0.60.10.4-1.6-1.5
Pavlov. Cond. lever-magazine prob. diff.0.00.10.1-0.40.3-0.10.10.20.30.2-0.30.30.1-0.3-0.2-0.3-0.1-0.3
Pavlov. Cond. response bias0.20.30.5-0.70.6-0.30.40.50.60.3-0.60.40.1-0.6-0.5-0.5-0.5-0.5
Pavlov. Cond. lever latency1.11.54.1-1.82.0-1.00.51.01.01.6-1.01.91.7-1.1-0.20.00.3-0.9
Pavlov. Cond. magazine entry latency0.20.20.7-0.2-0.4-0.40.80.40.4-0.1-0.3-0.5-0.6-0.0-0.7-0.7-0.60.2
Pavlov. Cond. change in total contacts0.91.43.81.6-2.00.9-0.6-1.1-1.1-1.31.2-1.6-1.21.30.50.10.21.2
Pavlov. Cond. index score0.40.51.60.7-1.00.20.5-0.00.0-0.9-0.0-1.1-1.30.1-0.7-0.9-1.00.2
Pavlov. Cond. latency score0.30.30.90.3-0.8-0.20.70.20.2-0.5-0.1-0.9-0.90.2-0.6-0.9-0.70.4
Pavlov. Cond. lever contacts1.31.74.52.0-2.11.2-0.7-1.2-1.1-1.71.2-1.9-1.71.20.40.1-0.20.9
Pavlov. Cond. magazine entry number0.10.20.6-0.20.7-0.1-0.20.30.30.3-0.40.70.3-0.6-0.20.2-0.2-0.8
Pavlov. Cond. intertrial magazine entries0.20.20.60.8-0.20.7-0.2-0.4-0.4-0.80.2-0.5-0.7-0.0-0.1-0.2-0.5-0.4
Pavlov. Cond. lever-magazine prob. diff.0.40.51.40.7-1.00.10.60.00.1-0.8-0.0-1.1-1.20.1-0.7-1.0-1.00.2
Pavlov. Cond. response bias1.11.43.81.9-2.01.0-0.5-1.0-0.9-1.60.9-1.8-1.70.90.1-0.1-0.40.7
Time in closed arm before self-admin0.50.61.20.6-0.60.7-0.7-0.7-0.8-0.60.9-0.9-0.80.90.81.10.60.9
Time in closed arm after self-admin5.66.015.11.3-1.60.9-2.9-2.0-2.40.32.7-0.11.83.03.43.33.93.1
Time in open arm before self-admin0.00.00.10.3-0.3-0.3-0.10.0-0.10.20.10.00.10.20.00.20.20.3
Time in open arm after self-admin0.80.93.10.3-0.30.50.80.00.3-1.2-0.5-0.9-1.8-0.7-1.1-0.9-1.7-1.0
Bone: periosteal estimation1.43.06.62.6-2.21.9-1.7-1.8-1.8-2.21.7-2.3-1.91.40.91.00.10.9
Bone: periosteal perimeter0.91.54.22.1-1.80.9-0.5-0.8-0.8-1.70.7-2.0-2.00.8-0.30.1-0.80.5
Bone: post-yield work0.50.82.71.6-1.11.0-0.7-0.6-0.5-1.30.3-1.1-1.3-0.1-0.20.4-0.9-0.5
Progressive ratio test 1 active lever presses2.02.55.7-2.22.0-2.41.91.81.72.0-1.41.71.3-0.9-1.0-1.00.1-0.1
Progressive ratio test 1 breakpoint1.82.35.3-2.11.9-2.31.81.71.61.9-1.31.61.2-0.8-0.9-0.90.10.0
Progressive ratio test 1 inactive lever presses3.14.47.2-2.72.6-2.22.22.42.42.1-2.42.11.2-2.2-1.7-1.9-1.1-1.6
Progressive ratio test 2 active lever presses4.45.28.6-2.92.8-2.52.72.72.72.1-2.71.90.6-2.4-2.2-1.4-1.3-1.7
Progressive ratio test 2 breakpoint4.35.08.1-2.82.8-2.42.72.62.72.0-2.61.80.5-2.4-2.2-1.4-1.4-1.7
Progressive ratio test 2 inactive lever presses3.96.411.3-2.92.3-2.53.43.03.21.5-3.10.8-0.8-2.7-3.2-2.1-2.6-1.7
Incentive Sensitization - Responses2.02.84.7-1.92.0-1.42.21.82.00.9-2.10.8-0.5-2.1-1.9-0.5-1.6-1.7
Incentive Sensitization - Breakpoint2.43.15.2-2.02.0-1.42.31.92.10.9-2.20.8-0.6-2.2-2.1-0.6-1.7-1.8
Sum of active levers in priming session hrs 5-60.80.82.7-0.10.1-0.20.50.60.8-0.3-1.00.0-1.0-1.3-1.3-0.3-1.6-1.5
Progressive ratio0.20.31.50.20.41.0-0.0-0.3-0.2-0.6-0.0-0.00.1-0.3-0.0-1.2-0.5-0.7
Food seeking constrained by brief footshock0.81.01.9-0.40.8-1.30.41.11.11.3-1.11.31.4-1.0-0.9-1.1-0.4-0.8
Seeking ratio, punishment vs. effort0.40.61.9-0.60.3-1.40.20.90.81.2-0.80.90.7-0.6-0.50.70.0-0.3
Retroperitoneal fat weight2.08.512.83.5-2.82.9-3.2-3.5-3.6-2.63.5-2.2-1.13.23.22.82.22.3
Reaction time number correct0.10.20.60.6-0.3-0.10.50.10.2-0.5-0.1-0.6-0.8-0.1-0.6-0.6-0.7-0.1
Reaction time mean minus median0.41.12.0-1.41.1-0.61.31.11.20.6-1.30.3-0.1-1.2-1.2-0.8-1.2-0.9
Reaction time mean minus median AUC0.40.92.8-0.90.5-0.21.20.81.0-0.2-1.0-0.4-1.1-1.0-1.3-1.0-1.7-0.9
Reaction time num false alarms1.72.44.3-1.41.5-1.81.11.81.71.9-1.72.11.7-1.6-1.3-1.2-0.6-1.3
Reaction time num false alarms AUC1.42.24.3-1.31.3-1.91.11.71.52.1-1.52.01.9-1.2-1.1-1.2-0.2-0.8
Reaction time trials correct on left0.10.20.60.6-0.3-0.10.50.10.2-0.5-0.1-0.6-0.8-0.1-0.6-0.6-0.7-0.1
Reaction time trials on left0.10.20.70.6-0.3-0.00.50.10.1-0.5-0.1-0.6-0.8-0.1-0.6-0.5-0.7-0.1
Reaction time mean0.20.30.6-0.70.70.5-0.5-0.2-0.10.3-0.10.70.7-0.50.50.50.3-0.8
Reaction time mean AUC0.20.31.1-0.80.70.30.00.10.20.2-0.50.60.4-0.80.00.2-0.3-1.0
Median of all reaction times0.40.61.6-0.30.40.8-1.1-0.7-0.70.10.40.71.0-0.01.21.01.0-0.5
Reaction time omissions0.10.11.1-1.00.60.10.20.10.10.3-0.10.10.3-0.10.20.30.2-0.0
Reaction time false alarm rate1.52.14.8-1.61.5-1.70.81.51.42.1-1.32.22.2-1.1-0.7-0.90.1-0.8
Reaction time premature initiation rate1.21.72.81.2-0.91.4-1.2-1.5-1.6-1.21.7-1.3-0.71.71.40.91.11.4
Reaction time premature initiations0.61.12.21.3-1.01.1-0.6-1.1-1.1-1.41.2-1.5-1.21.20.70.20.31.0
Std. dev. reaction times0.61.22.5-1.61.4-0.51.01.11.20.9-1.30.80.4-1.3-1.0-0.8-1.0-1.2
Reaction time trials completed0.10.20.70.6-0.3-0.00.50.10.1-0.5-0.1-0.6-0.8-0.1-0.6-0.5-0.7-0.1
Reaction time trials AUC0.10.30.91.0-0.60.20.2-0.2-0.1-0.80.1-0.8-1.00.0-0.4-0.3-0.6-0.1
Run reversals in cocaine runway, females0.70.72.3-1.50.9-0.81.00.90.90.7-0.80.50.6-0.6-0.5-1.0-0.3-0.1
Run reversals in cocaine runway, males0.30.31.10.4-0.5-0.10.60.20.2-0.5-0.1-0.9-1.10.2-0.7-0.5-0.70.4
Latency to leave start box in cocaine runway0.20.30.8-0.10.10.2-0.3-0.3-0.40.20.60.10.70.70.7-0.30.90.8
Latency to leave start box in cocaine runway, F0.50.53.0-0.50.60.0-0.5-0.2-0.30.80.40.81.70.50.9-0.21.20.6
Latency to leave start box in cocaine runway, M0.30.31.30.5-0.80.30.2-0.3-0.3-0.70.4-0.9-1.10.6-0.1-0.3-0.20.7
Std. dev. time between licks in bursts0.81.12.4-0.80.7-0.81.21.21.30.4-1.40.3-0.5-1.3-1.6-0.9-1.6-1.1
Total sessions with >9 infusions0.60.72.0-1.11.2-0.70.00.70.71.1-0.71.41.4-0.80.1-0.10.4-0.7
Short access day 1 total inactive lever presses2.22.96.0-2.32.4-1.01.51.71.81.4-2.01.70.8-2.2-1.4-0.5-1.0-2.0
Short access day 10 total inactive lever presses0.20.62.3-1.21.50.70.70.20.40.0-0.60.6-0.0-1.1-0.1-0.1-0.4-1.4
Short access day 1 total infusions0.81.14.4-0.91.3-0.8-0.30.50.51.3-0.61.92.1-0.90.3-0.20.8-0.9
Short access day 10 total infusions0.60.82.7-1.11.3-0.6-0.10.30.31.1-0.31.51.6-0.40.5-0.11.0-0.4
Short access total infusions0.70.82.6-1.11.3-0.90.10.50.51.2-0.51.61.6-0.60.4-0.30.9-0.4
Short access day 1 locomotion1.62.05.0-2.21.7-1.00.21.31.31.9-1.32.12.2-1.4-0.20.20.4-1.2
Short access day 10 total locomotion0.10.10.5-0.5-0.4-0.20.1-0.0-0.10.10.2-0.4-0.20.40.20.60.40.7
Short access total locomotion0.20.21.6-1.20.2-0.50.20.50.50.7-0.40.30.4-0.30.00.50.40.0
One hour access (0.3 mA shock)2.93.47.6-2.52.1-1.92.82.12.21.2-2.10.8-0.6-1.8-2.0-0.8-1.5-1.1
Compulsive drug intake0.91.12.31.3-1.51.2-1.1-1.1-1.2-1.01.2-1.0-0.51.11.00.50.60.9
One hour access (shock baseline)3.75.69.3-2.92.9-2.33.02.72.91.5-2.91.4-0.2-2.7-2.6-1.3-2.1-2.1
Social response proportion0.80.93.2-1.20.9-1.21.20.90.81.0-0.70.91.0-0.4-0.5-1.8-0.1-0.0
Social responses0.30.51.6-0.20.0-1.30.80.70.50.9-0.20.50.80.3-0.3-1.10.30.7
Social time0.10.10.30.2-0.30.00.3-0.2-0.2-0.30.3-0.5-0.50.40.0-0.3-0.00.5
Soleus weight1.23.56.22.5-2.51.8-1.6-1.9-1.9-2.01.9-2.4-1.81.91.11.80.51.5
Bone: stiffness0.10.10.50.5-0.30.1-0.00.10.1-0.3-0.2-0.3-0.6-0.3-0.50.1-0.7-0.3
Tibialis anterior weight6.020.334.95.5-4.45.9-5.6-5.5-5.2-5.14.6-4.0-3.03.24.25.21.81.1
Time to tail flick, vehicle, before self-admin2.22.35.6-0.71.6-1.20.71.51.61.2-1.91.81.2-2.3-1.4-0.1-1.3-2.4
Time to tail flick, vehicle, after self-admin1.01.32.30.5-0.91.2-1.0-1.3-1.3-1.01.3-1.0-0.81.21.41.51.11.1
Time to tail flick, test, before self-admin1.21.24.3-1.50.8-1.10.20.70.41.8-0.21.42.10.20.50.61.50.8
Time to tail flick, test, after self-admin0.60.62.2-0.2-0.2-0.7-0.40.2-0.10.90.40.21.50.90.6-0.01.31.5
Delta time to tail flick, vehicle, before/after SA2.12.03.70.4-1.41.4-0.7-1.5-1.5-1.31.7-1.7-1.41.91.50.81.21.9
Delta time to tail flick, test, before/after SA0.10.10.70.3-0.00.10.0-0.0-0.0-0.40.0-0.4-0.30.1-0.2-0.8-0.30.1
Tibia length0.00.00.2-0.20.3-0.40.20.20.20.3-0.20.30.1-0.2-0.0-0.10.1-0.0
Ambulatory time before self-admin0.40.52.20.10.21.00.0-0.3-0.1-1.1-0.2-0.6-1.5-0.6-0.40.6-1.1-1.0
Ambulatory time after self-admin0.81.01.90.7-0.90.8-1.4-1.1-1.2-0.41.2-0.30.41.11.31.11.20.9
Bone: tissue strength0.30.30.9-1.00.7-0.70.60.60.50.8-0.40.70.5-0.2-0.2-0.20.20.1
Total heroin consumption1.01.13.9-0.70.4-1.22.01.21.10.4-0.9-0.2-0.5-0.4-1.5-1.8-1.20.2
Bone: trabecular number0.20.40.90.5-0.40.5-0.7-0.6-0.7-0.10.7-0.10.20.70.90.81.00.6
Bone: trabecular spacing2.43.28.0-2.82.1-2.32.32.01.92.1-1.61.71.4-1.0-1.1-1.7-0.2-0.1
Bone: trabecular thickness1.01.23.82.0-1.41.2-1.6-1.2-1.2-1.21.0-0.9-0.60.70.90.90.40.1
Bone: trabecular tissue density0.50.72.3-0.80.4-1.50.51.00.81.3-0.50.71.1-0.0-0.5-0.70.40.6
Water consumed over 24 hours0.50.61.3-0.50.4-1.11.01.01.00.7-0.90.40.2-0.6-1.2-0.9-0.8-0.3
Number of responses in last shaping day1.31.44.0-1.80.9-1.50.71.31.12.0-0.91.61.8-0.5-0.1-0.50.80.2