Best TWAS P=1.270291e-09 · Best GWAS P=3.913983e-10 conditioned to 0.06647497
| # | Tissue | Gene | Modality | RNA phenotype | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Adipose | Ltbp1 | mRNA stability | ENSRNOG00000033090 | 0.21 | 0.13 | blup | 2403 | 0.16 | 1.8e-17 | 2.5 | -5.1 | 3.0e-07 | 0.65 | 1.00 | 0.00 | FALSE |
| 2 | BLA | Ltbp1 | gene expression | ENSRNOG00000033090 | 0.20 | 0.08 | blup | 2403 | 0.16 | 4.0e-09 | -3.9 | -5.2 | 1.6e-07 | 0.89 | 0.37 | 0.63 | FALSE |
| 3 | Brain | Ltbp1 | gene expression | ENSRNOG00000033090 | 0.49 | 0.35 | blup | 2403 | 0.40 | 4.5e-40 | -6.1 | -5.4 | 6.7e-08 | 0.95 | 0.16 | 0.84 | FALSE |
| 4 | IL | Ltbp1 | gene expression | ENSRNOG00000033090 | 0.32 | 0.23 | top1 | 1 | 0.23 | 2.9e-06 | -6.1 | -6.1 | 1.3e-09 | 0.90 | 0.14 | 0.35 | TRUE |
| 5 | PL | Rasgrp3 | mRNA stability | ENSRNOG00000032703 | 0.06 | 0.01 | top1 | 1 | 0.00 | 1.2e-01 | -5.3 | 5.3 | 1.3e-07 | -0.92 | 0.14 | 0.03 | FALSE |
h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.