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chr11:32,148,992-35,008,541

Best TWAS P=3.209645e-09 · Best GWAS P=2.591036e-09 conditioned to 1

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Cbr1	alternative polyA	ENSRNOT00000075105	0.32	0.22	enet	10	0.26	3.6e-29	-5.4	5.2	2.6e-07	-0.90	0.32	0.68	FALSE
2	Adipose	Cbr1	alternative polyA	ENSRNOT00000075985	0.32	0.21	enet	10	0.27	1.7e-29	-5.4	-5.2	2.5e-07	0.89	0.32	0.68	FALSE
3	Adipose	Ttc3	gene expression	ENSRNOG00000001682	0.32	0.34	lasso	53	0.36	8.4e-42	-5.8	5.4	6.5e-08	-0.75	0.41	0.59	FALSE
4	Adipose	Ripply3	gene expression	ENSRNOG00000001684	0.02	0.02	top1	1	0.02	2.0e-03	-5.8	-5.8	8.5e-09	0.96	0.06	0.04	FALSE
5	Adipose	Setd4	gene expression	ENSRNOG00000001699	0.57	0.47	enet	83	0.51	3.6e-65	-5.6	5.2	2.6e-07	-0.92	0.33	0.67	FALSE
6	Adipose	NA	gene expression	ENSRNOG00000067486	0.24	0.22	lasso	17	0.23	8.0e-25	4.1	5.3	9.4e-08	-0.33	1.00	0.00	TRUE
7	Adipose	Ttc3	intron excision ratio	chr11:33702457:33703457	0.02	0.02	top1	1	0.02	3.5e-03	-5.8	5.8	8.5e-09	-0.95	0.06	0.04	FALSE
8	BLA	Setd4	gene expression	ENSRNOG00000001699	0.41	0.27	enet	20	0.29	4.2e-16	-5.6	5.8	7.6e-09	-0.90	0.32	0.68	FALSE
9	BLA	Sim2	gene expression	ENSRNOG00000054203	0.05	0.04	top1	1	0.04	3.7e-03	-5.6	-5.6	2.5e-08	0.95	0.07	0.04	FALSE
10	BLA	U4	gene expression	ENSRNOG00000061658	0.06	0.03	top1	1	0.04	5.8e-03	-5.6	5.6	2.6e-08	-0.93	0.08	0.05	FALSE
11	BLA	NA	gene expression	ENSRNOG00000067486	0.19	0.16	blup	2012	0.22	2.9e-12	-5.6	5.2	2.4e-07	-0.89	0.55	0.45	FALSE
12	BLA	Cbr1	isoform ratio	ENSRNOT00000042283	0.47	0.36	blup	1975	0.37	1.1e-20	-5.6	5.6	1.8e-08	-0.92	0.31	0.69	FALSE
13	BLA	Cbr1	isoform ratio	ENSRNOT00000072384	0.07	0.01	blup	1975	0.02	4.1e-02	-5.6	-5.3	1.4e-07	0.84	0.32	0.40	FALSE
14	BLA	Ttc3	intron excision ratio	chr11:33721965:33734534	0.06	0.06	top1	1	0.06	6.1e-04	-5.8	5.8	7.1e-09	-0.96	0.08	0.06	FALSE
15	BLA	Setd4	intron excision ratio	chr11:32845874:32847402	0.08	0.03	top1	1	0.03	9.6e-03	-5.6	5.6	2.1e-08	-0.93	0.08	0.05	FALSE
16	BLA	Cbr1	intron excision ratio	chr11:32860952:32861423	0.14	0.11	blup	1975	0.13	1.2e-07	-5.6	5.2	1.8e-07	-0.89	0.42	0.58	FALSE
17	BLA	Vps26c	mRNA stability	ENSRNOG00000001681	0.14	0.12	blup	1882	0.12	4.7e-07	4.8	-5.1	2.9e-07	0.87	0.69	0.31	FALSE
18	Brain	Kcnj6	alternative polyA	ENSRNOT00000066940	0.57	0.32	enet	235	0.39	1.9e-38	-5.8	-5.1	3.3e-07	0.77	0.30	0.70	TRUE
19	Brain	Kcnj6	alternative polyA	ENSRNOT00000119355	0.57	0.32	enet	238	0.39	4.1e-38	-5.8	5.1	3.3e-07	-0.76	0.30	0.70	FALSE
20	Brain	Setd4	gene expression	ENSRNOG00000001699	0.44	0.43	enet	95	0.45	3.0e-45	-5.7	5.5	3.7e-08	-0.93	0.32	0.68	FALSE
21	Brain	Cbr1	gene expression	ENSRNOG00000049911	0.71	0.62	enet	60	0.71	5.0e-92	4.1	5.1	3.2e-07	-0.92	0.65	0.35	FALSE
22	Brain	U4	gene expression	ENSRNOG00000061658	0.21	0.16	top1	1	0.16	1.1e-14	-5.5	5.5	3.2e-08	-0.93	0.46	0.54	FALSE
23	Brain	NA	gene expression	ENSRNOG00000063617	0.10	0.10	lasso	11	0.11	1.8e-10	-5.7	-5.6	2.8e-08	0.92	0.31	0.69	FALSE
24	Brain	NA	gene expression	ENSRNOG00000067486	0.29	0.19	blup	2012	0.21	2.8e-19	-5.6	5.5	4.0e-08	-0.94	0.31	0.69	FALSE
25	Brain	Kcnj6	isoform ratio	ENSRNOT00000079955	0.32	0.02	top1	1	0.03	2.1e-03	-5.8	-5.8	8.3e-09	0.92	0.08	0.06	FALSE
26	Brain	Setd4	isoform ratio	ENSRNOT00000002308	0.07	0.03	enet	40	0.05	3.9e-05	-5.7	-5.6	2.1e-08	-0.19	0.33	0.65	FALSE
27	Brain	Setd4	isoform ratio	ENSRNOT00000104229	0.07	0.04	enet	32	0.05	2.6e-05	-5.7	5.6	1.9e-08	0.52	0.33	0.66	TRUE
28	Brain	Cbr1	isoform ratio	ENSRNOT00000042283	0.52	0.40	enet	76	0.50	1.7e-52	-5.6	5.5	3.4e-08	-0.90	0.32	0.68	FALSE
29	Brain	Cbr1	isoform ratio	ENSRNOT00000114595	0.20	0.21	top1	1	0.21	2.1e-19	-5.7	-5.7	1.6e-08	0.89	0.30	0.70	FALSE
30	Brain	Kcnj6	intron excision ratio	chr11:34250394:34308566	0.06	0.04	enet	15	0.04	7.1e-05	4.6	5.3	1.4e-07	-0.91	0.50	0.49	TRUE
31	Brain	Kcnj6	intron excision ratio	chr11:34276411:34308566	0.04	0.03	blup	2461	0.03	1.7e-03	-5.9	-5.6	2.2e-08	0.94	0.39	0.58	FALSE
32	Brain	Ttc3	intron excision ratio	chr11:33721965:33734534	0.16	0.13	enet	28	0.18	2.7e-16	-5.8	5.3	1.1e-07	-0.73	0.37	0.63	FALSE
33	Brain	Setd4	intron excision ratio	chr11:32845874:32847402	0.08	0.04	blup	1972	0.05	2.7e-05	-5.4	5.2	2.4e-07	-0.83	0.32	0.68	FALSE
34	Brain	Setd4	intron excision ratio	chr11:32845874:32853438	0.43	0.01	enet	38	0.08	5.0e-08	2.0	-5.1	3.0e-07	0.90	0.66	0.33	FALSE
35	Brain	Setd4	intron excision ratio	chr11:32847490:32850712	0.06	0.04	blup	1972	0.06	4.1e-06	-5.6	5.4	6.2e-08	-0.91	0.34	0.66	FALSE
36	Brain	Cbr1	intron excision ratio	chr11:32877739:32878644	0.15	0.13	blup	1975	0.18	4.0e-16	-5.6	5.3	1.1e-07	-0.88	0.33	0.67	FALSE
37	Brain	Cbr1	intron excision ratio	chr11:32893820:32894725	0.13	0.15	enet	11	0.15	3.9e-14	-5.8	-5.7	1.3e-08	0.94	0.32	0.69	FALSE
38	Brain	Kcnj6	mRNA stability	ENSRNOG00000001658	0.39	0.16	lasso	14	0.17	1.8e-15	-5.8	5.8	8.3e-09	0.96	0.29	0.71	FALSE
39	Brain	Vps26c	mRNA stability	ENSRNOG00000001681	0.06	0.04	lasso	18	0.04	5.1e-05	-5.6	-5.9	3.2e-09	0.95	0.42	0.58	TRUE
40	Brain	Setd4	mRNA stability	ENSRNOG00000001699	0.11	0.06	top1	1	0.06	2.4e-06	-5.6	-5.6	2.3e-08	0.94	0.28	0.44	FALSE
41	Eye	Vps26c	intron excision ratio	chr11:33826532:33827030	0.34	0.01	top1	1	0.01	2.0e-01	-5.6	5.6	1.8e-08	-0.95	0.11	0.06	FALSE
42	IL	Cbr1	alternative polyA	ENSRNOT00000075105	0.17	-0.01	blup	1972	0.04	4.2e-02	-5.7	5.4	7.5e-08	-0.87	0.30	0.46	FALSE
43	IL	Cbr1	alternative polyA	ENSRNOT00000075985	0.16	-0.01	blup	1972	0.03	5.6e-02	-5.7	-5.4	8.6e-08	0.86	0.29	0.43	FALSE
44	IL	Cbr1	alternative polyA	ENSRNOT00000072384	0.13	0.16	top1	1	0.16	9.6e-05	-5.7	5.7	1.6e-08	-0.91	0.10	0.06	FALSE
45	IL	Cbr1	alternative polyA	ENSRNOT00000114595	0.13	0.17	top1	1	0.17	8.9e-05	-5.7	-5.7	1.6e-08	0.91	0.10	0.06	TRUE
46	IL	Setd4	gene expression	ENSRNOG00000001699	0.53	0.39	lasso	5	0.41	5.2e-11	-5.6	5.6	1.6e-08	-0.87	0.31	0.69	FALSE
47	IL	Cbr1	gene expression	ENSRNOG00000049911	0.64	0.37	enet	14	0.56	5.8e-16	4.2	5.2	2.6e-07	-0.90	0.55	0.45	FALSE
48	IL	Cbr1	isoform ratio	ENSRNOT00000042283	0.46	0.19	lasso	7	0.27	4.0e-07	-5.6	5.6	2.4e-08	-0.92	0.33	0.67	FALSE
49	IL	Cbr1	isoform ratio	ENSRNOT00000072384	0.28	0.22	top1	1	0.22	6.7e-06	-5.6	-5.6	1.8e-08	0.94	0.12	0.10	FALSE
50	IL	Setd4	intron excision ratio	chr11:32845874:32847402	0.13	0.12	top1	1	0.12	8.4e-04	-5.7	5.7	1.4e-08	-0.94	0.10	0.06	FALSE
51	IL	Setd4	intron excision ratio	chr11:32845874:32853438	0.15	0.11	top1	1	0.11	1.2e-03	-5.7	-5.7	1.4e-08	0.93	0.10	0.07	FALSE
52	LHb	Ripply3	gene expression	ENSRNOG00000001684	0.13	0.04	blup	1884	0.04	4.5e-02	-5.8	-5.7	1.5e-08	0.95	0.32	0.41	FALSE
53	LHb	Setd4	gene expression	ENSRNOG00000001699	0.32	0.17	blup	1969	0.30	8.8e-08	-5.7	5.2	1.8e-07	-0.83	0.34	0.66	FALSE
54	LHb	Cbr1	isoform ratio	ENSRNOT00000042283	0.41	0.21	enet	44	0.38	7.0e-10	-5.6	5.4	7.7e-08	-0.86	0.32	0.68	FALSE
55	LHb	Vps26c	mRNA stability	ENSRNOG00000001681	0.14	0.04	blup	1874	0.11	1.3e-03	-5.8	-5.6	2.4e-08	0.91	0.35	0.46	FALSE
56	Liver	Cldn14	alternative TSS	ENSRNOT00000002297	0.29	0.29	lasso	17	0.30	5.4e-34	-5.7	-5.6	1.7e-08	0.94	0.34	0.66	FALSE
57	Liver	Cldn14	alternative TSS	ENSRNOT00000102693	0.28	0.29	lasso	17	0.30	1.4e-33	-5.7	5.6	1.7e-08	-0.94	0.34	0.66	FALSE
58	Liver	Ripply3	gene expression	ENSRNOG00000001684	0.04	0.03	blup	1890	0.03	3.6e-04	-5.8	-5.6	2.8e-08	0.91	0.36	0.63	FALSE
59	Liver	Cldn14	gene expression	ENSRNOG00000001691	0.03	0.02	enet	21	0.02	4.7e-03	-5.6	5.5	3.2e-08	-0.93	0.48	0.45	FALSE
60	Liver	Setd4	gene expression	ENSRNOG00000001699	0.29	0.26	enet	41	0.27	1.8e-29	-5.6	5.6	1.6e-08	-0.93	0.31	0.69	FALSE
61	Liver	Cbr3	gene expression	ENSRNOG00000001701	0.04	0.01	blup	1942	0.02	2.4e-03	3.2	-5.2	1.6e-07	0.83	0.29	0.60	FALSE
62	Liver	Dop1b	gene expression	ENSRNOG00000051204	0.07	0.06	top1	1	0.06	2.5e-07	-5.6	5.6	1.8e-08	-0.91	0.32	0.67	FALSE
63	Liver	Cldn14	isoform ratio	ENSRNOT00000002297	0.29	0.30	lasso	8	0.31	3.2e-35	-5.7	-5.7	1.6e-08	0.94	0.35	0.65	FALSE
64	Liver	Cldn14	isoform ratio	ENSRNOT00000102693	0.29	0.32	top1	1	0.32	6.6e-36	-5.7	5.7	1.5e-08	-0.96	0.37	0.63	FALSE
65	Liver	Cldn14	intron excision ratio	chr11:33233296:33241680	0.05	0.04	top1	1	0.04	1.0e-05	-5.6	-5.6	2.6e-08	0.93	0.35	0.35	FALSE
66	Liver	Cldn14	intron excision ratio	chr11:33233296:33242036	0.16	0.11	lasso	25	0.12	4.3e-13	-5.7	5.4	7.9e-08	-0.92	0.34	0.66	FALSE
67	Liver	Vps26c	mRNA stability	ENSRNOG00000001681	0.07	0.06	blup	1881	0.07	2.0e-08	-5.6	-5.5	4.3e-08	0.93	0.55	0.45	FALSE
68	NAcc	Setd4	gene expression	ENSRNOG00000001699	0.59	0.35	top1	1	0.35	1.5e-08	-5.7	5.7	1.2e-08	-0.94	0.19	0.48	FALSE
69	NAcc	Cbr1	isoform ratio	ENSRNOT00000042283	0.65	0.21	blup	1972	0.29	3.2e-07	-5.7	5.2	2.4e-07	-0.82	0.35	0.64	FALSE
70	NAcc	Cbr1	isoform ratio	ENSRNOT00000072384	0.29	0.11	top1	1	0.11	1.6e-03	-5.4	-5.4	8.0e-08	0.91	0.10	0.05	FALSE
71	NAcc2	Cbr1	alternative polyA	ENSRNOT00000072384	0.23	0.31	lasso	15	0.33	3.3e-18	4.3	5.2	2.5e-07	-0.92	0.97	0.03	FALSE
72	NAcc2	Cbr1	alternative polyA	ENSRNOT00000114595	0.23	0.30	lasso	13	0.32	9.6e-18	4.3	-5.2	2.0e-07	0.93	0.97	0.03	FALSE
73	NAcc2	Hlcs	gene expression	ENSRNOG00000001686	0.05	0.04	top1	1	0.04	2.3e-03	-5.7	-5.7	1.0e-08	0.95	0.08	0.06	FALSE
74	NAcc2	Setd4	gene expression	ENSRNOG00000001699	0.33	0.23	blup	1972	0.30	1.6e-16	-5.6	5.6	1.7e-08	-0.92	0.30	0.70	FALSE
75	NAcc2	NA	gene expression	ENSRNOG00000063617	0.14	0.07	blup	1979	0.08	5.8e-05	-5.8	-5.4	5.6e-08	0.88	0.28	0.69	FALSE
76	NAcc2	NA	gene expression	ENSRNOG00000067486	0.18	0.16	enet	34	0.22	4.2e-12	4.3	5.7	1.5e-08	-0.90	0.81	0.19	FALSE
77	NAcc2	Cbr1	isoform ratio	ENSRNOT00000042283	0.53	0.36	enet	87	0.47	1.5e-28	-5.7	5.2	2.4e-07	-0.82	0.28	0.72	FALSE
78	NAcc2	Cbr1	isoform ratio	ENSRNOT00000072384	0.11	0.05	blup	1975	0.06	2.6e-04	-5.5	-5.7	1.0e-08	0.93	0.30	0.70	FALSE
79	NAcc2	Cbr1	isoform ratio	ENSRNOT00000114595	0.17	0.14	lasso	19	0.16	3.3e-09	-5.7	-5.3	1.2e-07	0.87	0.41	0.59	FALSE
80	NAcc2	Cbr1	intron excision ratio	chr11:32861530:32862436	0.08	0.06	blup	1975	0.06	2.6e-04	-5.7	-5.7	1.1e-08	0.92	0.30	0.60	FALSE
81	NAcc2	Cbr1	intron excision ratio	chr11:32877739:32878644	0.06	0.03	enet	17	0.05	9.4e-04	-5.6	5.5	3.3e-08	-0.90	0.38	0.53	FALSE
82	NAcc2	Vps26c	mRNA stability	ENSRNOG00000001681	0.08	0.06	blup	1882	0.07	7.6e-05	-5.8	-5.5	2.9e-08	0.94	0.48	0.51	FALSE
83	OFC	Setd4	gene expression	ENSRNOG00000001699	0.33	0.26	top1	1	0.26	8.2e-07	-5.6	5.6	1.8e-08	-0.92	0.19	0.29	FALSE
84	OFC	Cbr1	isoform ratio	ENSRNOT00000042283	0.45	0.23	lasso	8	0.37	1.1e-09	-5.7	5.2	1.8e-07	-0.86	0.45	0.54	FALSE
85	OFC	Cbr1	isoform ratio	ENSRNOT00000072384	0.13	0.07	blup	1972	0.07	8.3e-03	-5.7	-5.3	9.2e-08	0.89	0.39	0.35	FALSE
86	PL	Cbr1	alternative polyA	ENSRNOT00000075105	0.14	0.08	top1	1	0.08	5.7e-03	-5.7	5.7	1.6e-08	-0.90	0.10	0.06	FALSE
87	PL	Cbr1	alternative polyA	ENSRNOT00000075985	0.14	0.08	top1	1	0.08	6.2e-03	-5.7	-5.7	1.6e-08	0.90	0.10	0.06	FALSE
88	PL	Ripply3	gene expression	ENSRNOG00000001684	0.12	0.02	enet	7	0.03	5.5e-02	-5.4	-5.2	1.5e-07	0.92	0.38	0.30	FALSE
89	PL	Setd4	gene expression	ENSRNOG00000001699	0.45	0.22	blup	1969	0.26	5.4e-07	-5.6	5.3	1.2e-07	-0.84	0.32	0.67	FALSE
90	PL	Cbr1	isoform ratio	ENSRNOT00000072384	0.20	0.14	top1	1	0.14	2.8e-04	-5.6	-5.6	2.9e-08	0.93	0.11	0.07	FALSE
91	PL	Vps26c	mRNA stability	ENSRNOG00000001681	0.16	0.06	blup	1876	0.11	1.2e-03	-5.8	-5.8	7.2e-09	0.98	0.38	0.44	FALSE
92	PL2	Hlcs	gene expression	ENSRNOG00000001686	0.13	0.10	lasso	15	0.10	3.3e-06	-5.7	-5.7	1.4e-08	0.95	0.35	0.65	FALSE
93	PL2	Setd4	gene expression	ENSRNOG00000001699	0.40	0.27	blup	1972	0.29	5.9e-16	-5.6	5.7	1.1e-08	-0.94	0.31	0.69	FALSE
94	PL2	Cbr1	isoform ratio	ENSRNOT00000114595	0.17	0.12	blup	1975	0.15	1.1e-08	-5.6	-5.4	7.5e-08	0.92	0.34	0.66	FALSE
95	PL2	Ttc3	intron excision ratio	chr11:33727139:33728112	0.05	0.01	blup	1972	0.02	2.0e-02	-5.7	-5.6	2.6e-08	0.92	0.32	0.42	FALSE
96	PL2	Setd4	intron excision ratio	chr11:32845874:32853438	0.13	0.08	top1	1	0.08	5.8e-05	-5.7	-5.7	1.6e-08	0.94	0.13	0.20	FALSE
97	PL2	Morc3	intron excision ratio	chr11:33163168:33163995	0.07	0.06	top1	1	0.06	6.0e-04	-5.8	-5.8	8.5e-09	0.93	0.08	0.09	FALSE
98	PL2	Kcnj6	mRNA stability	ENSRNOG00000001658	0.09	0.03	top1	1	0.03	1.0e-02	-5.8	5.8	7.6e-09	-0.90	0.10	0.05	FALSE
99	PL2	Vps26c	mRNA stability	ENSRNOG00000001681	0.13	0.10	enet	93	0.11	2.5e-06	-5.8	-5.5	3.4e-08	0.93	0.44	0.56	FALSE
100	PL2	Setd4	mRNA stability	ENSRNOG00000001699	0.11	0.10	top1	1	0.10	4.2e-06	-5.6	-5.6	2.1e-08	0.87	0.24	0.39	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.