Hub : Genes

LOC108352311

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	LOC108352311	0.03	0.02	3.9e-03	0.03	0.03	0.01	0.02	1.3e-03	2.1e-03	2.1e-02	3.5e-03
2	PL	gene expression	LOC108352311	0.1	0.06	2.6e-11	0.11	0.1	0.1	0.11	2.9e-12	2.6e-11	7.0e-11	7.1e-12
3	Liver	gene expression	LOC108352311	0.04	0.02	1.0e-04	0.02	0.02	0.02	0.02	2.6e-03	2.7e-03	2.6e-03	3.8e-03
4	NAcc	gene expression	LOC108352311	0.07	0.05	2.4e-06	0.05	0.05	0.05	0.06	9.3e-07	1.2e-06	1.3e-06	2.2e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.0	0.0	0.1	0.1	0.1	0.3	0.2
Area under the delay curve	0.2	0.3	0.7	0.4	0.4	0.8	-0.2
BMI with tail	0.2	0.7	1.2	-1.1	-0.9	-0.6	0.8
BMI without tail	0.0	0.0	0.1	0.1	-0.0	0.2	-0.3
Body weight	0.1	0.5	0.6	-0.7	-0.8	-0.6	0.8
Weight adjusted by age	1.6	1.8	2.4	1.5	1.2	1.2	-1.5
Bone surface	3.6	6.4	7.3	-2.7	-2.5	-2.2	2.7
Bone volume	2.1	3.5	4.6	-1.8	-1.9	-1.6	2.1
Breakpoint value in progressive ratio session	0.0	0.0	0.1	0.1	0.2	0.3	0.1
Number of licking bursts	0.5	0.6	0.8	0.8	0.6	0.9	-0.8
Context. condit. distance diff. score	0.1	0.1	0.2	0.3	0.4	0.4	-0.3
Locomotion velocity, session 1	0.1	0.1	0.1	-0.3	-0.0	-0.2	0.4
Locomotion distance, session 1	0.4	0.5	1.1	-0.8	-0.2	-0.4	1.1
Locomotion velocity, session 2	0.1	0.1	0.2	-0.4	0.1	-0.2	0.4
Locomotion distance, session 2	0.2	0.2	0.4	0.1	0.5	0.6	0.6
Locomotion velocity, session 3	4.1	4.7	6.3	-2.5	-1.9	-2.2	2.0
Locomotion distance, session 3	0.7	0.8	1.6	-1.3	-0.7	-0.7	0.8
Stereotopy head waving bouts, day 3	0.8	0.9	1.7	-1.0	-0.9	-1.3	0.2
Stereotopy head waving duration, day 3	0.8	1.0	1.9	-0.9	-1.0	-1.4	0.4
Locomotion velocity, session 7	1.6	1.7	2.1	1.1	1.5	1.4	-1.2
Locomotion distance, session 7	2.6	3.3	5.2	1.3	2.1	2.3	-1.4
Stereotopy head waving bouts, day 7	2.1	2.3	3.9	-1.3	-1.5	-2.0	1.2
Stereotopy head waving duration, day 7	2.2	2.7	4.3	-1.3	-1.6	-2.1	1.4
Locomotion velocity, session 8	2.7	3.2	4.1	-2.0	-1.7	-2.0	1.4
Locomotion distance, session 8	0.2	0.2	0.5	0.1	0.6	0.7	0.2
Degree of sensitization distance	3.3	3.3	3.9	1.7	1.9	2.0	-1.6
Degree of sensitization stereotypy	3.0	3.3	4.2	-1.5	-1.8	-2.1	1.8
Conditioned locomotion	0.9	1.0	1.2	1.0	1.0	0.9	-1.1
Cocaine response after cond. corrected	0.1	0.1	0.3	0.4	0.6	0.2	0.1
Cocaine response after cond. not corrected	0.4	0.5	1.0	0.7	1.0	0.7	-0.1
Cocaine response before conditioning	0.1	0.1	0.3	0.2	0.4	0.6	0.2
Saline control response	0.4	0.5	0.6	-0.8	-0.6	-0.8	0.8
Bone: connectivity density	0.5	0.8	1.3	-1.0	-0.8	-0.5	1.1
Bone: cortical apparent density	0.2	0.2	0.9	0.1	-0.1	-0.1	0.9
Bone: cortical area	0.0	0.0	0.1	-0.1	-0.1	-0.3	0.3
Bone: cortical porosity	0.4	0.4	0.6	0.8	0.7	0.7	-0.3
Bone: cortical porosity	0.5	0.5	0.7	0.8	0.8	0.8	-0.3
Bone: cortical thickness	1.9	3.1	4.4	2.1	1.8	1.5	-1.5
Bone: cortical thickness	0.6	0.7	1.1	1.1	0.7	0.8	-0.6
Bone: cortical tissue density	0.2	0.3	1.0	-0.0	-0.2	-0.1	1.0
Condit. Reinf. active minus inactive responses	0.0	0.0	0.1	0.0	0.0	0.1	-0.2
Condit. Reinf. active-inactive response ratio	0.4	0.4	1.0	0.5	0.5	0.4	-1.0
Condit. Reinf. active responses	0.1	0.1	0.3	-0.1	-0.1	-0.0	0.5
Condit. Reinf. inactive responses	0.4	0.5	1.7	-0.4	-0.3	-0.3	1.3
Incentive salience index mean	0.1	0.1	0.3	0.3	0.3	0.4	-0.5
Condit. Reinf. lever presses	0.4	0.5	0.6	0.8	0.7	0.7	-0.8
Condit. Reinf. active minus inactive responses	0.3	0.3	0.7	-0.5	-0.4	-0.4	0.9
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.1	-0.0	0.0	0.3	0.2
Condit. Reinf. active responses	0.7	0.9	1.2	-1.1	-0.8	-1.0	0.9
Condit. Reinf. inactive responses	0.7	0.9	1.3	-1.1	-0.7	-1.1	0.6
Condit. Reinf. lever presses	0.4	0.5	0.8	-0.7	-0.8	-0.9	0.2
Condit. Reinf. lever reinforcers received	0.8	1.1	1.4	-1.2	-0.9	-1.1	1.0
Conditioned reinforcement - actives	0.4	0.4	0.7	0.6	0.7	0.8	-0.1
Conditioned reinforcement - inactives	2.3	2.6	3.2	1.8	1.8	1.4	-1.4
Conditioned locomotion	0.2	0.3	0.4	0.5	0.6	0.5	-0.5
Patch foraging indifference point 0 sec	1.7	2.8	4.1	1.8	1.7	1.0	-2.0
Patch foraging indifference point AUC	1.3	1.5	2.0	-1.1	-1.1	-1.4	1.2
Delay disc. indifference point, 0s delay	0.1	0.1	0.4	-0.2	-0.1	0.0	0.6
Delay disc. indifference point, 16s delay	0.1	0.1	0.2	0.1	0.1	0.5	-0.3
Delay disc. indifference point, 2s delay	0.1	0.1	0.4	-0.2	-0.2	0.1	0.6
Delay disc. indifference point, 24s delay	1.1	1.0	1.6	1.1	1.0	1.2	-0.7
Delay disc. indifference point, 4s delay	0.1	0.1	0.2	0.0	-0.0	0.2	0.4
Delay disc. indifference point, 8s delay	0.8	0.8	1.0	0.8	0.8	1.0	-1.0
Indifference point function ln k	1.2	1.7	2.4	1.5	1.3	1.2	-1.2
Indifference point function log k	1.2	1.7	2.4	1.5	1.3	1.2	-1.2
Patch foraging total patch changes 0 sec	1.2	1.9	2.9	1.5	1.3	0.7	-1.7
Patch foraging total patch changes 12 sec	0.6	0.8	1.9	-0.7	-0.8	-1.4	0.4
Patch foraging total patch changes 18 sec	0.3	0.4	0.9	-0.3	-0.5	-0.9	0.5
Patch foraging total patch changes 24 sec	0.2	0.3	0.6	-0.4	-0.6	-0.8	0.4
Patch foraging total patch changes 6 sec	0.1	0.2	0.6	-0.3	-0.1	-0.7	0.1
Patch foraging time to switch 0 sec	0.1	0.1	0.2	-0.4	-0.0	0.4	0.4
Patch foraging water rate 0 sec	1.1	1.8	3.6	-1.0	-1.4	-1.9	0.9
Patch foraging water rate 12 sec	2.2	3.3	4.0	1.8	1.9	1.5	-2.0
Patch foraging water rate 18 sec	0.3	0.4	0.8	-0.6	-0.9	-0.7	0.1
Patch foraging water rate 24 sec	0.5	0.7	0.9	1.0	0.8	0.8	-0.7
Patch foraging water rate 6 sec	0.1	0.2	0.2	0.5	0.4	0.3	-0.4
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.4	0.2	0.0	0.2	0.6
Distance traveled before self-admin	0.1	0.1	0.2	-0.4	-0.2	-0.2	0.3
Distance traveled after self-admin	0.1	0.1	0.4	-0.7	-0.4	0.1	0.0
Extensor digitorum longus weight	5.1	20.1	21.5	-4.4	-4.6	-4.5	4.3
Bone: elastic displacement	0.4	0.4	0.6	0.7	0.6	0.6	-0.8
Bone: elastic work	0.0	0.0	0.1	0.1	-0.0	-0.2	-0.3
Bone: endosteal estimation	3.7	8.0	10.7	-3.3	-2.9	-2.5	2.7
Bone: endosteal perimeter	1.8	3.7	4.9	-2.2	-1.7	-1.7	2.0
Epididymis fat weight	4.2	9.9	11.0	-3.3	-3.1	-2.8	3.3
Delta time in closed arm before/after self-admin	0.1	0.1	0.2	-0.1	-0.0	0.5	-0.1
Delta time in open arm before/after self-admin	0.5	0.5	0.6	-0.7	-0.8	-0.8	0.3
Diff in mean of infusions in LGA sessions	0.5	0.6	0.9	-0.6	-0.5	-1.0	0.8
Delay discount exponential model param	0.3	0.3	0.7	-0.4	-0.4	-0.8	0.2
Extinction: sum of active levers before priming	0.1	0.1	0.3	-0.2	-0.3	-0.6	0.3
Active lever presses in extinction session 6	0.4	0.4	1.3	0.1	0.5	-0.1	-1.1
Bone: final force	0.3	0.6	0.8	-0.8	-0.8	-0.9	0.4
Bone: final moment	0.3	0.6	0.8	-0.8	-0.8	-0.9	0.4
Food consumed during 24 hour testing period	0.5	0.6	0.9	0.9	1.0	0.7	-0.6
Glucose	4.9	7.3	7.7	-2.7	-2.6	-2.8	2.7
Heart weight	0.7	0.9	1.7	-0.8	-1.3	-0.8	0.9
Delay discount hyperbolic model param	0.1	0.1	0.4	-0.3	-0.3	-0.6	-0.0
Intermittent access intake day 1-15 change	0.7	0.7	1.3	1.1	0.9	0.5	-0.7
Intermittent access intake escalation	0.6	0.6	1.0	1.0	0.8	0.4	-0.8
Intermittent access intake escalation 2	0.3	0.3	0.5	0.5	0.7	0.1	-0.5
Intermitt. access day 1 inactive lever presses	3.9	4.2	6.1	2.0	1.9	1.8	-2.5
Intermitt. access day 15 inactive lever presses	0.6	0.7	1.0	1.0	0.8	0.6	-0.7
Intermitt. access escalation Index	0.2	0.2	0.4	0.6	0.3	0.3	-0.5
Intermittent access day 1 total infusions	0.6	0.7	1.3	1.1	0.9	0.8	-0.3
Intermittent access day 15 total infusions	2.5	2.8	3.7	1.9	1.9	1.2	-1.5
Intermittent access terminal intake (last 3 days)	2.4	2.7	3.5	1.9	1.8	1.2	-1.5
Intermittent access total infusions	1.9	2.2	2.7	1.7	1.6	1.1	-1.4
Intermittent access day 1 locomotion	2.5	2.6	3.7	1.9	1.7	1.7	-1.0
Intermittent access day 15 total locomotion	0.6	0.6	1.1	1.0	1.0	0.5	-0.5
Intermittent access total locomotion	2.4	2.7	3.8	1.9	1.9	1.4	-1.3
Intermittent access standard deviation	0.5	0.5	0.9	0.6	0.9	0.3	-1.0
Left kidney weight	1.7	4.9	6.4	2.4	2.2	2.5	-1.5
Right kidney weight	2.5	7.1	8.6	2.7	2.7	2.9	-2.4
Cocaine induced anxiety	0.0	0.0	0.0	0.2	0.2	-0.1	-0.1
Post-drug Anxiety	0.3	0.3	0.5	-0.5	-0.3	-0.7	0.7
Baseline Anxiety	0.0	0.0	0.1	-0.3	0.0	0.0	0.3
Tail length	0.7	2.1	3.1	1.8	1.4	1.1	-1.5
Length with tail	0.1	0.3	0.7	0.8	0.4	0.3	-0.4
Length without tail	0.0	0.0	0.0	-0.1	-0.1	-0.2	0.2
Times rat made contact with spout	9.1	10.5	11.9	3.3	3.4	3.1	-3.1
Lifetime Intake	0.8	0.9	1.1	1.1	1.1	0.7	-0.9
Liver weight, left	0.2	0.3	0.8	0.9	0.6	0.5	-0.1
Liver weight, right	0.1	0.2	0.4	0.3	0.5	0.6	-0.1
Locomotor activity	4.5	7.2	8.0	2.5	2.8	2.7	-2.7
Locomotor testing distance	2.1	3.6	4.4	1.8	2.1	1.7	-1.9
Locomotor testing rearing	1.0	1.6	2.0	1.3	1.3	1.4	-1.0
Locomotion in novel chamber	0.2	0.2	0.6	0.8	0.5	0.1	-0.2
Locomotion in novel chamber post-restriction	1.9	2.3	2.5	-1.3	-1.6	-1.6	1.6
Fecal boli incidents, locomotor time 1	0.4	0.5	0.8	0.8	0.6	0.9	-0.3
Change in fecal boli incidents, locomotor task	2.7	2.5	3.0	1.6	1.7	1.6	-1.5
Time >=10cm from walls, locomotor time 1	0.6	0.6	1.3	0.9	0.5	0.4	-1.1
Bouts of movement, locomotor time 1	0.1	0.1	0.3	-0.2	-0.2	-0.4	0.5
Total resting periods, locomotor time 1	0.0	0.0	0.1	0.0	-0.1	-0.2	0.3
Rest time, locomotor task time 1	0.2	0.2	0.5	-0.5	-0.3	-0.0	0.7
Distance moved, locomotor task time 1	0.3	0.4	1.3	0.2	0.2	0.2	-1.2
Vertical activity count, locomotor time 1	0.1	0.2	0.3	-0.2	-0.3	-0.6	-0.4
Time >=10cm from walls, locomotor time 2	0.6	0.6	1.2	-0.7	-1.1	-0.7	0.4
Bouts of movement, locomotor time 2	1.8	2.0	3.5	-1.0	-1.3	-1.3	1.9
Total resting periods, locomotor time 2	0.5	0.5	1.2	-0.3	-0.6	-0.6	1.1
Rest time, locomotor task time 2	0.5	0.6	1.2	0.7	1.1	0.7	-0.3
Distance moved, locomotor task time 2	0.7	0.8	1.2	-1.0	-1.1	-0.8	0.4
Vertical activity count, locomotor time 2	1.1	1.2	1.8	-1.1	-1.3	-1.2	0.5
Light reinforcement 1	0.0	0.1	0.3	0.0	-0.2	0.2	0.5
Light reinforcement 2	4.0	5.3	6.3	-2.3	-2.5	-2.1	2.4
Bone: marrow area	3.8	8.2	10.8	-3.3	-2.9	-2.5	2.7
Bone: maximum diameter	0.9	1.7	1.8	-1.3	-1.3	-1.3	1.3
Bone: maximum force	0.5	0.8	1.1	-0.9	-0.9	-1.0	0.6
Bone: maximum moment	0.4	0.7	0.9	-0.8	-0.9	-1.0	0.6
Mean time between licks in bursts	2.6	3.7	4.2	1.6	2.1	2.0	-2.0
Mean num. licks in bursts	0.6	0.8	1.2	0.9	1.1	0.6	-0.9
Cd content in liver	1.5	1.7	2.9	1.2	1.2	1.0	-1.7
Co content in liver	0.0	0.0	0.0	-0.1	-0.2	-0.1	0.1
Cu content in liver	0.0	0.1	0.1	-0.1	-0.3	-0.3	0.1
Fe content in liver	0.5	0.6	1.5	-0.5	-0.8	-1.2	-0.0
K content in liver	0.6	0.6	0.9	-0.9	-1.0	-0.8	0.2
Mg content in liver	0.9	0.9	1.3	-0.9	-1.1	-1.1	0.3
Mn content in liver	1.2	1.3	2.4	-1.1	-1.0	-0.8	1.5
Na content in liver	4.1	4.3	4.7	-2.1	-2.0	-2.2	2.0
Rb content in liver	0.4	0.6	1.0	1.0	0.6	0.7	-0.7
Se content in liver	0.2	0.2	0.6	0.5	0.3	-0.0	-0.8
Sr content in liver	2.9	2.6	2.7	1.6	1.6	1.6	-1.6
Zn content in liver	0.4	0.5	1.1	0.6	0.6	0.3	-1.1
Bone: minimum diameter	4.5	8.5	10.2	-3.2	-2.9	-2.8	2.7
Time in familiar zone, hab. session 1	0.2	0.1	0.3	0.1	0.3	0.4	0.6
Time in novel zone, hab. session 1	0.8	0.8	1.1	-1.0	-1.1	-0.9	0.2
Total zone transitions, hab. session 1	2.0	2.7	3.8	1.4	2.0	1.9	-1.3
Total locomotion distance, hab. session 1	1.9	2.7	3.3	1.6	1.8	1.8	-1.4
Locomotion velocity, hab. session 1	2.1	2.9	3.6	1.6	1.9	1.9	-1.4
Time in familiar zone, hab. session 2	0.3	0.3	0.7	-0.6	-0.5	-0.2	0.8
Time in novel zone, hab. session 2	0.1	0.1	0.2	0.4	0.2	0.1	-0.5
Total zone transitions, hab. session 2	1.2	1.6	3.0	0.8	1.5	1.7	-0.6
Total locomotion distance, hab. session 2	2.8	3.7	5.9	1.7	2.1	2.4	-1.3
Locomotion velocity, hab. session 2	2.8	3.7	6.0	1.6	2.2	2.5	-1.2
Novel to familiar place preference ratio	0.0	0.0	0.1	-0.1	0.1	0.2	-0.1
Novelty place preference	0.1	0.1	0.2	-0.4	-0.3	-0.1	0.3
Time in novel zone, NPP test	0.2	0.2	0.3	-0.6	-0.5	-0.2	0.5
Total zone transitions, NPP test	0.1	0.2	0.4	0.2	0.6	0.5	0.2
Total locomotion distance, NPP test	0.4	0.5	0.9	0.5	0.8	0.9	-0.3
Locomotion velocity, NPP test	0.6	0.8	1.4	0.8	1.1	1.2	-0.4
Intraocular pressure	0.2	0.2	0.3	-0.4	-0.6	-0.4	0.5
Delta distance traveled before/after self-admin	0.2	0.2	0.7	0.1	0.3	0.8	-0.5
Delta ambulatory time before/after self-admin	0.4	0.4	0.9	0.2	0.4	1.0	-0.7
Parametrial fat weight	1.2	2.4	2.9	-1.7	-1.6	-1.3	1.6
Pavlov. Cond. lever latency	0.1	0.1	0.1	0.2	0.2	0.4	-0.4
Pavlov. Cond. magazine entry latency	0.5	0.7	0.8	0.9	0.8	0.9	-0.7
Pavlov. Cond. change in total contacts	0.1	0.1	0.1	0.4	0.1	0.2	0.3
Pavlov. Cond. index score	0.1	0.1	0.2	0.4	0.4	0.3	-0.3
Pavlov. Cond. latency score	0.1	0.2	0.2	0.5	0.4	0.4	-0.3
Pavlov. Cond. lever contacts	0.0	0.1	0.1	0.3	0.3	0.1	-0.1
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	-0.3	-0.3	-0.3	0.4
Pavlov. Cond. intertrial magazine entries	5.2	6.3	9.7	-2.2	-2.6	-3.1	1.9
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.1	0.4	0.3	0.2	-0.3
Pavlov. Cond. response bias	0.2	0.3	0.4	0.7	0.6	0.4	-0.4
Pavlov. Cond. lever latency	1.2	1.6	2.0	1.2	1.3	1.4	-1.0
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	0.3	0.2	0.1	-0.2
Pavlov. Cond. change in total contacts	0.7	0.9	1.1	-0.8	-1.0	-0.9	1.1
Pavlov. Cond. index score	0.1	0.1	0.4	-0.2	-0.4	-0.6	0.1
Pavlov. Cond. latency score	0.0	0.0	0.0	0.1	-0.0	-0.2	-0.2
Pavlov. Cond. lever contacts	0.5	0.7	0.9	-0.8	-0.9	-1.0	0.7
Pavlov. Cond. magazine entry number	0.1	0.1	0.1	0.2	0.3	0.3	-0.3
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.4	-0.6	-0.4	-0.6	0.5
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	-0.1	-0.2	-0.5	0.0
Pavlov. Cond. response bias	0.4	0.5	0.7	-0.6	-0.8	-0.8	0.6
Time in closed arm before self-admin	0.4	0.4	0.6	-0.6	-0.7	-0.6	0.8
Time in closed arm after self-admin	0.5	0.5	1.1	-0.7	-0.5	0.4	1.0
Time in open arm before self-admin	0.1	0.1	0.2	0.3	0.4	0.5	-0.2
Time in open arm after self-admin	0.2	0.2	0.6	-0.4	-0.4	-0.8	0.0
Bone: periosteal estimation	1.7	3.4	4.1	-2.0	-1.8	-1.7	1.8
Bone: periosteal perimeter	0.6	1.0	1.5	-1.1	-0.8	-0.9	1.2
Bone: post-yield work	1.1	1.4	2.2	-1.1	-1.2	-1.5	1.0
Progressive ratio test 1 active lever presses	0.7	0.7	1.1	1.1	0.8	0.9	-0.6
Progressive ratio test 1 breakpoint	1.1	1.1	1.5	1.2	1.0	1.1	-0.9
Progressive ratio test 1 inactive lever presses	1.1	1.2	1.5	1.2	1.1	0.9	-1.2
Progressive ratio test 2 active lever presses	1.3	1.4	2.1	1.3	1.5	0.9	-0.9
Progressive ratio test 2 breakpoint	1.1	1.3	1.9	1.3	1.4	0.8	-0.9
Progressive ratio test 2 inactive lever presses	1.8	2.1	3.2	1.8	1.7	1.0	-1.1
Incentive Sensitization - Responses	0.1	0.1	0.1	0.0	0.4	-0.3	0.2
Incentive Sensitization - Breakpoint	0.1	0.1	0.2	0.1	0.4	-0.3	0.3
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.3	-0.2	-0.1	-0.6	-0.3
Progressive ratio	0.1	0.1	0.1	-0.0	-0.3	-0.4	-0.2
Food seeking constrained by brief footshock	1.9	2.3	2.5	1.6	1.5	1.4	-1.6
Seeking ratio, punishment vs. effort	1.1	1.4	1.7	1.0	1.3	1.3	-1.1
Retroperitoneal fat weight	2.1	6.9	7.5	-2.7	-2.6	-2.5	2.7
Reaction time number correct	0.1	0.1	0.2	-0.0	-0.1	-0.4	0.5
Reaction time mean minus median	0.3	0.4	0.6	0.8	0.8	0.4	-0.3
Reaction time mean minus median AUC	0.1	0.1	0.1	0.2	0.2	-0.3	0.4
Reaction time num false alarms	3.2	4.4	5.5	1.9	2.1	2.0	-2.3
Reaction time num false alarms AUC	3.8	5.2	5.8	2.1	2.3	2.3	-2.4
Reaction time trials correct on left	0.1	0.1	0.2	-0.0	-0.1	-0.4	0.5
Reaction time trials on left	0.1	0.1	0.2	-0.0	-0.1	-0.4	0.5
Reaction time mean	0.1	0.1	0.3	-0.5	-0.4	-0.3	0.3
Reaction time mean AUC	0.0	0.1	0.1	-0.3	-0.2	-0.2	0.1
Median of all reaction times	0.3	0.5	0.8	-0.9	-0.8	-0.5	0.5
Reaction time omissions	0.0	0.1	0.2	-0.4	0.0	-0.0	0.1
Reaction time false alarm rate	3.3	4.6	5.7	1.9	2.0	2.2	-2.4
Reaction time premature initiation rate	1.0	1.3	1.7	-1.0	-1.2	-1.1	1.3
Reaction time premature initiations	0.9	1.3	1.8	-0.9	-1.0	-1.2	1.3
Std. dev. reaction times	0.3	0.4	0.7	0.7	0.8	0.6	-0.5
Reaction time trials completed	0.1	0.1	0.2	-0.0	-0.1	-0.4	0.5
Reaction time trials AUC	0.2	0.2	0.4	-0.3	-0.3	-0.6	0.6
Run reversals in cocaine runway, females	0.5	0.5	0.9	1.0	0.7	0.7	-0.3
Run reversals in cocaine runway, males	0.1	0.1	0.1	0.2	0.2	0.0	0.4
Latency to leave start box in cocaine runway	0.1	0.1	0.4	-0.1	-0.1	0.0	0.6
Latency to leave start box in cocaine runway, F	0.1	0.2	0.5	0.2	0.4	0.7	-0.1
Latency to leave start box in cocaine runway, M	0.9	0.8	1.6	-0.7	-0.7	-0.9	1.3
Std. dev. time between licks in bursts	0.5	0.7	0.8	0.8	0.9	0.5	-0.9
Total sessions with >9 infusions	0.7	0.8	0.9	0.9	0.8	1.0	-0.9
Short access day 1 total inactive lever presses	2.5	2.8	4.7	1.6	1.6	1.3	-2.2
Short access day 10 total inactive lever presses	0.2	0.3	0.5	-0.7	-0.4	-0.6	-0.2
Short access day 1 total infusions	0.1	0.1	0.2	0.4	0.3	0.2	-0.5
Short access day 10 total infusions	0.0	0.0	0.1	0.1	-0.1	0.0	-0.2
Short access total infusions	0.1	0.1	0.2	0.3	0.1	0.3	-0.4
Short access day 1 locomotion	1.1	1.2	1.4	1.0	1.0	1.1	-1.2
Short access day 10 total locomotion	0.1	0.1	0.2	0.4	0.2	0.4	0.0
Short access total locomotion	0.1	0.1	0.3	0.4	0.2	0.5	-0.2
One hour access (0.3 mA shock)	0.6	0.7	1.1	0.9	1.1	0.8	-0.7
Compulsive drug intake	0.8	0.8	1.0	-1.0	-0.9	-0.7	1.0
One hour access (shock baseline)	1.1	1.3	1.7	1.2	1.3	0.8	-1.1
Social response proportion	1.0	1.1	1.6	1.3	0.9	0.9	-1.0
Social responses	0.9	1.2	1.6	1.3	1.0	1.1	-0.9
Social time	0.0	0.1	0.1	0.0	-0.2	-0.3	0.3
Soleus weight	0.8	2.3	2.7	-1.6	-1.6	-1.5	1.2
Bone: stiffness	0.0	0.0	0.1	0.1	0.1	-0.0	-0.3
Tibialis anterior weight	9.1	31.0	33.2	-5.6	-5.8	-5.6	5.4
Time to tail flick, vehicle, before self-admin	4.3	4.4	6.3	2.3	1.8	1.7	-2.5
Time to tail flick, vehicle, after self-admin	2.3	2.5	2.8	-1.7	-1.6	-1.3	1.6
Time to tail flick, test, before self-admin	0.9	0.9	1.6	0.9	0.9	1.3	-0.6
Time to tail flick, test, after self-admin	0.7	0.7	1.6	0.8	0.7	1.3	-0.4
Delta time to tail flick, vehicle, before/after SA	5.3	5.3	6.5	-2.4	-2.2	-2.0	2.5
Delta time to tail flick, test, before/after SA	0.0	0.0	0.0	0.0	-0.1	-0.0	-0.1
Tibia length	0.0	0.0	0.0	0.1	0.0	0.1	-0.2
Ambulatory time before self-admin	0.7	0.8	1.0	-1.0	-0.8	-0.8	0.9
Ambulatory time after self-admin	0.3	0.3	0.8	-0.9	-0.6	-0.3	0.3
Bone: tissue strength	0.5	0.5	0.8	0.7	0.6	0.5	-0.9
Total heroin consumption	1.9	2.3	3.0	1.7	1.7	1.4	-1.1
Bone: trabecular number	0.0	0.1	0.1	0.1	0.1	0.3	0.3
Bone: trabecular spacing	2.3	3.0	3.9	2.0	1.7	1.7	-1.6
Bone: trabecular thickness	0.8	1.0	1.1	-0.9	-1.0	-1.0	1.1
Bone: trabecular tissue density	1.3	1.9	2.6	1.4	1.5	1.6	-0.8
Water consumed over 24 hours	0.7	0.8	1.0	0.8	0.9	0.9	-1.0
Number of responses in last shaping day	1.1	1.1	1.5	1.1	0.9	1.2	-1.0