Hub : Genes

Topors

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 LHb gene expression Topors 0.14 0.1 3.8e-03 0.09 0.08 0.08 0.07 4.7e-03 5.2e-03 6.3e-03 8.2e-03
2 Brain mRNA stability Topors 0.03 0.02 2.7e-03 0.02 0.03 0.02 0.02 1.2e-02 7.9e-04 3.3e-03 1.1e-02
3 Adipose mRNA stability Topors 0.08 0.05 1.4e-08 0.07 0.07 0.06 0.07 1.6e-08 4.1e-08 9.4e-08 3.6e-08
4 PL gene expression Topors 0.09 0.06 1.6e-05 0.05 0.04 0.05 0.04 5.7e-06 1.0e-04 6.7e-06 1.3e-05
5 pVTA gene expression Topors 0.05 0.04 4.9e-04 0.05 0.05 0.04 0.04 1.2e-04 5.5e-05 3.6e-04 2.8e-04
6 BLA gene expression Topors 0.08 0.05 1.1e-03 0.01 0.05 0.04 0.03 1.5e-01 1.2e-03 3.9e-03 1.4e-02
7 Adipose gene expression Topors 0.04 0.03 2.1e-03 0.01 0.01 0.01 0.01 5.9e-02 2.7e-02 8.6e-03 3.7e-02
8 NAcc gene expression Topors 0.02 0.01 2.0e-03 0.01 0.02 0.01 0.02 3.6e-02 1.5e-03 2.6e-03 1.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density1.12.12.8-1.2-1.61.6-1.71.71.51.40.2
Area under the delay curve0.40.60.90.70.8-1.00.8-0.9-0.80.1-0.7
BMI with tail1.03.45.7-1.9-2.42.0-2.11.91.60.91.5
BMI without tail0.84.46.7-2.5-2.62.5-2.32.01.71.51.2
Body weight1.67.114.2-3.8-3.52.8-2.92.11.32.51.3
Weight adjusted by age0.10.31.1-0.6-0.1-0.0-0.2-0.5-0.81.1-0.4
Bone surface0.71.43.4-1.3-1.41.2-1.21.00.71.8-0.4
Bone volume0.71.52.9-1.2-1.41.3-1.21.21.01.7-0.3
Breakpoint value in progressive ratio session2.44.37.50.61.6-2.12.1-2.5-2.61.4-2.7
Number of licking bursts2.57.810.7-3.0-3.13.3-3.22.92.41.12.5
Context. condit. distance diff. score0.10.10.30.40.5-0.20.4-0.3-0.2-0.50.0
Locomotion velocity, session 12.12.36.8-1.00.9-0.40.8-2.0-2.61.6-1.6
Locomotion distance, session 10.81.02.2-0.80.40.00.3-1.1-1.51.4-1.3
Locomotion velocity, session 21.82.23.6-1.7-1.61.9-1.61.51.30.11.3
Locomotion distance, session 20.91.23.8-1.9-0.91.4-1.20.4-0.21.20.3
Locomotion velocity, session 31.01.23.2-0.11.0-0.60.7-1.5-1.80.8-1.2
Locomotion distance, session 30.40.51.3-1.1-0.40.6-0.5-0.2-0.61.1-0.1
Stereotopy head waving bouts, day 30.10.10.4-0.5-0.20.2-0.1-0.2-0.50.6-0.3
Stereotopy head waving duration, day 30.10.10.2-0.4-0.50.5-0.40.40.30.4-0.0
Locomotion velocity, session 70.20.20.40.40.5-0.40.6-0.5-0.4-0.4-0.3
Locomotion distance, session 70.10.10.4-0.20.4-0.00.2-0.5-0.60.10.1
Stereotopy head waving bouts, day 72.02.34.3-2.1-1.61.9-1.81.20.80.51.4
Stereotopy head waving duration, day 71.72.13.3-1.8-1.81.8-1.81.41.00.61.0
Locomotion velocity, session 80.40.41.7-1.00.40.20.2-0.9-1.3-0.00.0
Locomotion distance, session 80.30.41.3-0.80.50.20.1-0.8-1.10.4-0.1
Degree of sensitization distance0.30.30.70.80.7-0.60.6-0.2-0.1-0.80.2
Degree of sensitization stereotypy2.02.33.6-1.9-1.61.9-1.81.31.00.61.3
Conditioned locomotion1.41.75.3-0.10.8-0.60.6-1.2-1.51.8-2.3
Cocaine response after cond. corrected1.82.66.80.71.3-1.51.3-1.7-1.81.4-2.6
Cocaine response after cond. not corrected1.72.57.20.41.1-1.21.1-1.6-1.81.7-2.7
Cocaine response before conditioning1.11.32.0-1.2-1.41.4-1.31.10.90.11.2
Saline control response1.11.63.6-1.9-1.51.3-1.30.80.21.60.2
Bone: connectivity density0.60.91.4-0.6-1.21.0-1.01.21.10.9-0.2
Bone: cortical apparent density0.50.81.60.0-0.60.6-0.51.11.2-1.11.2
Bone: cortical area4.06.510.8-2.2-3.32.8-2.63.02.80.62.2
Bone: cortical porosity0.20.20.90.10.30.1-0.10.10.1-1.00.6
Bone: cortical porosity0.20.20.7-0.4-0.10.4-0.40.20.1-0.60.8
Bone: cortical thickness2.74.57.0-1.5-2.42.3-2.12.62.7-0.12.0
Bone: cortical thickness0.20.30.8-0.1-0.40.6-0.50.70.90.4-0.1
Bone: cortical tissue density0.40.61.20.1-0.40.4-0.30.91.1-1.01.1
Condit. Reinf. active minus inactive responses0.20.20.5-0.7-0.40.6-0.60.30.20.10.6
Condit. Reinf. active-inactive response ratio0.80.92.41.11.0-0.90.9-0.6-0.4-1.60.4
Condit. Reinf. active responses1.82.33.5-1.9-1.81.8-1.71.31.01.50.7
Condit. Reinf. inactive responses2.93.85.6-2.1-2.42.2-2.11.81.52.30.2
Incentive salience index mean2.02.65.2-2.3-1.91.9-1.91.20.71.40.9
Condit. Reinf. lever presses5.48.116.8-4.1-3.33.2-3.32.00.93.20.7
Condit. Reinf. active minus inactive responses0.40.61.4-0.7-1.20.7-0.71.00.90.30.4
Condit. Reinf. active-inactive response ratio0.10.10.4-0.0-0.30.2-0.20.50.6-0.30.3
Condit. Reinf. active responses1.21.73.6-1.2-1.91.2-1.31.51.20.41.0
Condit. Reinf. inactive responses2.02.95.6-1.4-2.41.7-1.82.01.80.71.4
Condit. Reinf. lever presses2.23.26.2-0.9-2.51.4-1.62.32.2-0.62.0
Condit. Reinf. lever reinforcers received1.31.94.1-1.3-2.01.3-1.41.61.30.31.1
Conditioned reinforcement - actives0.00.10.20.4-0.5-0.4-0.00.40.4-0.3-0.1
Conditioned reinforcement - inactives0.00.10.30.00.1-0.40.1-0.3-0.40.5-0.5
Conditioned locomotion0.10.10.20.20.4-0.40.1-0.4-0.4-0.0-0.3
Patch foraging indifference point 0 sec0.51.44.2-0.70.6-0.60.5-1.5-2.11.2-1.2
Patch foraging indifference point AUC1.74.27.1-2.6-2.72.4-2.21.81.21.61.4
Delay disc. indifference point, 0s delay0.60.71.00.71.0-1.00.8-0.9-0.9-0.4-0.6
Delay disc. indifference point, 16s delay1.52.23.31.11.2-1.81.6-1.7-1.70.7-1.8
Delay disc. indifference point, 2s delay0.70.81.8-0.0-0.60.3-0.91.01.0-1.01.3
Delay disc. indifference point, 24s delay0.10.20.40.70.5-0.60.3-0.3-0.2-0.2-0.3
Delay disc. indifference point, 4s delay0.10.10.20.50.4-0.40.4-0.3-0.2-0.30.0
Delay disc. indifference point, 8s delay0.00.00.0-0.0-0.10.0-0.10.10.10.10.1
Indifference point function ln k0.61.92.81.41.7-1.61.4-1.4-1.2-0.5-1.4
Indifference point function log k0.61.92.81.41.7-1.61.4-1.4-1.2-0.5-1.4
Patch foraging total patch changes 0 sec0.31.02.6-1.30.10.0-0.1-1.0-1.61.5-0.9
Patch foraging total patch changes 12 sec0.50.61.3-1.0-1.10.9-0.80.70.50.50.6
Patch foraging total patch changes 18 sec0.00.10.1-0.4-0.3-0.00.1-0.2-0.30.4-0.2
Patch foraging total patch changes 24 sec0.31.12.6-1.6-1.21.1-1.10.70.31.10.5
Patch foraging total patch changes 6 sec0.61.03.0-1.7-1.00.9-0.70.0-0.61.4-0.1
Patch foraging time to switch 0 sec0.51.84.52.11.5-1.51.5-0.8-0.2-1.4-0.7
Patch foraging water rate 0 sec0.20.72.6-1.6-0.80.9-0.90.2-0.40.90.5
Patch foraging water rate 12 sec0.00.10.3-0.6-0.00.0-0.1-0.1-0.3-0.00.6
Patch foraging water rate 18 sec0.92.14.3-0.7-1.31.4-1.41.61.6-1.02.1
Patch foraging water rate 24 sec0.71.02.3-0.6-0.51.1-1.01.11.1-0.81.5
Patch foraging water rate 6 sec1.31.93.5-1.9-1.31.7-1.71.30.80.71.0
Seeking ratio, delayed vs. immediate footshock0.40.61.2-0.9-1.10.8-0.80.80.50.50.6
Distance traveled before self-admin1.73.78.8-3.0-1.72.3-2.21.10.32.40.7
Distance traveled after self-admin3.46.110.0-2.7-2.43.2-2.92.52.00.72.5
Extensor digitorum longus weight3.915.726.0-4.6-5.14.3-4.34.13.22.33.0
Bone: elastic displacement3.74.78.42.92.7-2.42.5-1.8-1.0-2.1-1.0
Bone: elastic work1.31.85.72.00.7-0.80.90.51.3-2.40.4
Bone: endosteal estimation0.30.91.9-1.4-1.40.8-0.90.50.11.20.3
Bone: endosteal perimeter0.41.02.3-1.4-1.50.8-0.80.60.21.40.1
Epididymis fat weight0.10.71.2-0.8-0.80.9-1.10.80.70.60.8
Delta time in closed arm before/after self-admin0.30.30.50.1-0.30.4-0.20.60.7-0.50.7
Delta time in open arm before/after self-admin0.20.30.60.30.1-0.70.8-0.4-0.40.0-0.7
Diff in mean of infusions in LGA sessions0.20.41.50.6-0.2-0.00.20.30.6-1.20.7
Delay discount exponential model param0.40.60.9-0.7-0.80.9-0.80.90.8-0.10.7
Extinction: sum of active levers before priming1.52.23.41.51.8-1.71.9-1.6-1.3-0.5-1.3
Active lever presses in extinction session 60.00.00.1-0.2-0.00.2-0.0-0.00.00.3-0.1
Bone: final force1.93.25.3-1.8-2.32.0-1.82.01.70.41.5
Bone: final moment1.93.15.1-1.5-2.31.9-1.72.11.90.11.6
Food consumed during 24 hour testing period0.51.02.1-1.5-1.41.0-1.00.60.10.90.8
Glucose0.81.32.7-1.5-1.61.2-1.31.00.60.40.9
Heart weight0.50.82.2-0.9-1.50.7-0.80.90.90.80.1
Delay discount hyperbolic model param0.40.50.8-0.6-0.80.9-0.70.80.8-0.10.6
Intermittent access intake day 1-15 change0.10.41.3-0.3-1.10.6-0.40.80.9-0.10.5
Intermittent access intake escalation0.10.81.6-0.4-1.30.8-0.51.11.2-0.40.8
Intermittent access intake escalation 21.32.23.8-0.8-1.71.6-1.31.91.9-0.51.6
Intermitt. access day 1 inactive lever presses0.00.30.9-0.9-0.00.4-0.6-0.2-0.50.80.3
Intermitt. access day 15 inactive lever presses0.00.20.4-0.5-0.40.6-0.40.20.10.20.6
Intermitt. access escalation Index0.10.20.4-0.6-0.40.6-0.60.30.20.10.6
Intermittent access day 1 total infusions0.72.03.21.21.7-1.81.5-1.6-1.4-0.5-1.1
Intermittent access day 15 total infusions0.10.20.70.3-0.4-0.10.10.40.6-0.80.6
Intermittent access terminal intake (last 3 days)0.10.20.4-0.3-0.60.3-0.40.60.5-0.30.6
Intermittent access total infusions0.00.00.10.0-0.2-0.30.0-0.0-0.0-0.10.1
Intermittent access day 1 locomotion0.81.52.70.91.6-1.31.4-1.5-1.3-0.5-0.7
Intermittent access day 15 total locomotion0.51.82.91.41.4-1.61.7-1.5-1.1-0.8-0.8
Intermittent access total locomotion0.70.81.91.21.0-0.90.9-0.6-0.3-1.40.1
Intermittent access standard deviation0.00.00.1-0.2-0.0-0.1-0.2-0.2-0.30.2-0.1
Left kidney weight0.21.85.5-2.4-1.51.1-0.90.1-0.52.0-0.1
Right kidney weight0.10.93.1-1.3-1.80.6-0.70.70.50.80.2
Cocaine induced anxiety0.20.51.2-1.1-0.30.9-1.10.50.00.9-0.1
Post-drug Anxiety1.71.94.0-2.0-1.11.5-1.70.80.22.0-0.1
Baseline Anxiety0.50.81.6-0.8-1.31.0-0.90.90.80.60.6
Tail length0.84.27.0-2.6-2.62.2-2.31.91.31.80.9
Length with tail0.62.87.5-2.7-1.91.4-1.60.6-0.22.5-0.1
Length without tail0.10.61.6-0.60.1-0.60.3-0.9-1.31.0-0.8
Times rat made contact with spout0.50.60.9-0.8-0.70.9-0.90.90.80.40.8
Lifetime Intake0.10.10.1-0.1-0.1-0.40.2-0.3-0.40.2-0.3
Liver weight, left0.10.20.4-0.7-0.60.3-0.40.30.10.50.1
Liver weight, right0.30.51.31.00.5-1.00.8-0.4-0.10.2-1.1
Locomotor activity0.00.00.10.30.2-0.20.1-0.1-0.0-0.30.2
Locomotor testing distance0.20.61.00.10.7-0.60.6-0.9-1.00.8-1.0
Locomotor testing rearing0.10.51.6-0.9-0.70.5-0.70.20.01.3-0.3
Locomotion in novel chamber0.40.61.3-0.9-0.41.1-1.00.70.6-0.00.8
Locomotion in novel chamber post-restriction1.75.06.9-2.0-2.42.6-2.52.52.40.32.3
Fecal boli incidents, locomotor time 11.23.16.32.51.6-2.22.2-1.2-0.8-1.1-1.5
Change in fecal boli incidents, locomotor task0.90.93.3-1.8-0.31.2-1.2-0.0-0.40.80.7
Time >=10cm from walls, locomotor time 10.30.31.1-0.10.4-0.20.0-0.5-0.70.8-1.0
Bouts of movement, locomotor time 11.01.22.61.61.1-1.51.2-0.9-0.6-0.6-0.8
Total resting periods, locomotor time 11.51.84.52.11.3-1.81.4-0.8-0.4-1.2-0.7
Rest time, locomotor task time 10.81.24.21.50.2-0.30.20.81.3-2.00.9
Distance moved, locomotor task time 10.41.14.5-1.4-0.30.4-0.4-0.6-1.12.1-0.9
Vertical activity count, locomotor time 10.21.13.6-1.6-0.10.4-0.4-0.7-1.31.9-0.7
Time >=10cm from walls, locomotor time 20.10.41.00.30.6-0.80.3-0.5-0.70.5-1.0
Bouts of movement, locomotor time 20.31.12.1-1.4-1.41.2-0.81.00.80.80.6
Total resting periods, locomotor time 20.20.61.2-1.0-1.10.9-0.60.80.70.50.5
Rest time, locomotor task time 20.10.20.70.80.6-0.40.4-0.10.2-0.7-0.1
Distance moved, locomotor task time 20.10.10.10.3-0.3-0.0-0.10.30.4-0.30.2
Vertical activity count, locomotor time 20.00.10.3-0.2-0.2-0.1-0.0-0.0-0.30.5-0.3
Light reinforcement 10.31.55.7-1.5-0.90.1-0.2-0.7-1.32.4-1.2
Light reinforcement 20.61.43.4-1.2-0.1-0.20.2-1.1-1.71.8-1.3
Bone: marrow area0.41.02.2-1.4-1.50.9-1.00.70.31.00.5
Bone: maximum diameter2.95.710.1-2.4-3.22.6-2.52.72.30.82.0
Bone: maximum force3.36.511.1-2.6-3.32.8-2.72.82.40.72.1
Bone: maximum moment3.15.810.0-2.3-3.22.6-2.52.82.50.42.1
Mean time between licks in bursts0.10.62.00.70.5-0.80.8-0.7-0.60.5-1.4
Mean num. licks in bursts1.43.85.42.32.2-2.32.3-1.9-1.5-0.8-1.7
Cd content in liver1.71.93.5-1.4-1.91.4-1.41.51.40.61.1
Co content in liver1.11.33.60.60.7-1.11.0-1.0-1.01.3-1.9
Cu content in liver0.70.81.91.41.0-1.11.0-0.6-0.3-0.4-0.9
Fe content in liver1.31.63.10.71.1-1.31.3-1.4-1.40.6-1.7
K content in liver0.80.81.50.50.8-0.80.7-0.9-1.00.8-1.2
Mg content in liver1.21.32.71.11.2-1.31.2-1.1-0.90.4-1.7
Mn content in liver2.42.63.9-1.4-2.01.8-1.92.01.70.31.2
Na content in liver0.50.51.41.20.8-0.90.9-0.4-0.1-0.5-0.5
Rb content in liver4.45.27.32.52.6-2.72.6-2.4-1.9-1.3-1.6
Se content in liver2.93.45.1-1.7-2.22.1-2.32.11.80.71.5
Sr content in liver0.50.40.5-0.6-0.70.7-0.70.70.60.10.7
Zn content in liver0.10.10.30.1-0.40.2-0.20.50.60.10.0
Bone: minimum diameter0.10.10.40.4-0.4-0.10.20.40.6-0.20.2
Time in familiar zone, hab. session 11.21.34.80.7-0.70.6-0.61.72.2-0.80.8
Time in novel zone, hab. session 13.74.28.20.82.0-2.02.1-2.7-2.90.5-2.2
Total zone transitions, hab. session 10.20.20.90.10.60.00.2-0.2-0.2-1.00.6
Total locomotion distance, hab. session 11.31.83.3-0.7-0.91.5-1.31.51.6-0.81.8
Locomotion velocity, hab. session 12.33.35.4-1.4-1.62.1-2.02.01.9-0.72.3
Time in familiar zone, hab. session 20.60.71.71.2-0.0-0.40.30.61.1-1.30.6
Time in novel zone, hab. session 21.92.14.40.41.6-1.21.3-1.9-2.10.6-1.7
Total zone transitions, hab. session 20.60.82.3-1.30.00.7-0.4-0.5-1.01.5-0.7
Total locomotion distance, hab. session 20.91.22.1-1.4-1.01.5-1.30.90.60.41.1
Locomotion velocity, hab. session 21.01.42.3-1.5-1.11.5-1.41.00.80.31.2
Novel to familiar place preference ratio3.64.77.11.92.7-2.52.3-2.6-2.4-1.2-1.2
Novelty place preference4.35.58.52.22.9-2.72.6-2.7-2.4-1.5-1.2
Time in novel zone, NPP test5.36.510.02.43.2-2.92.8-2.9-2.6-1.6-1.4
Total zone transitions, NPP test0.40.71.9-1.4-0.20.9-0.6-0.2-0.61.30.0
Total locomotion distance, NPP test1.11.64.1-2.0-1.01.6-1.40.50.11.40.8
Locomotion velocity, NPP test1.42.04.5-2.1-1.31.9-1.60.90.41.41.0
Intraocular pressure0.81.32.5-1.6-1.51.2-1.30.90.61.10.6
Delta distance traveled before/after self-admin0.50.51.0-0.5-0.70.9-0.60.80.8-0.41.0
Delta ambulatory time before/after self-admin0.30.51.3-0.7-0.41.1-0.60.60.6-0.31.0
Parametrial fat weight0.51.12.4-0.10.8-0.70.7-1.3-1.41.2-1.6
Pavlov. Cond. lever latency4.65.811.73.42.8-2.92.9-1.9-1.0-2.2-0.9
Pavlov. Cond. magazine entry latency0.30.30.7-0.8-0.80.6-0.60.50.20.6-0.3
Pavlov. Cond. change in total contacts1.21.33.7-1.9-1.01.4-1.30.4-0.21.30.3
Pavlov. Cond. index score2.32.95.1-2.3-2.02.0-2.11.50.91.50.4
Pavlov. Cond. latency score2.02.54.6-2.1-1.91.9-1.91.40.81.50.3
Pavlov. Cond. lever contacts4.35.210.2-3.2-2.62.7-2.81.91.11.81.1
Pavlov. Cond. magazine entry number0.40.50.80.90.9-0.80.9-0.7-0.5-0.60.1
Pavlov. Cond. intertrial magazine entries0.20.20.7-0.3-0.50.3-0.50.40.5-0.10.8
Pavlov. Cond. lever-magazine prob. diff.2.32.84.3-2.1-2.02.0-2.11.61.21.30.6
Pavlov. Cond. response bias2.43.06.0-2.5-2.02.0-2.11.40.71.60.5
Pavlov. Cond. lever latency1.92.74.90.92.2-1.41.5-2.2-2.10.3-1.7
Pavlov. Cond. magazine entry latency0.30.41.30.9-0.1-0.50.40.40.6-1.20.3
Pavlov. Cond. change in total contacts0.82.04.20.0-1.40.8-0.91.82.1-1.31.9
Pavlov. Cond. index score0.71.02.20.4-0.90.2-0.31.31.5-1.31.2
Pavlov. Cond. latency score0.81.42.90.2-1.20.4-0.51.51.7-1.41.4
Pavlov. Cond. lever contacts1.52.34.1-0.7-2.01.1-1.22.02.0-0.51.6
Pavlov. Cond. magazine entry number0.81.02.5-0.40.8-0.30.4-1.3-1.61.3-1.1
Pavlov. Cond. intertrial magazine entries0.10.20.5-0.7-0.40.5-0.50.1-0.00.50.3
Pavlov. Cond. lever-magazine prob. diff.0.81.22.60.4-1.00.3-0.41.41.6-1.51.4
Pavlov. Cond. response bias1.11.63.4-0.1-1.50.7-0.81.71.8-0.81.3
Time in closed arm before self-admin0.20.30.70.80.5-0.70.3-0.4-0.2-0.6-0.3
Time in closed arm after self-admin0.10.10.40.40.20.1-0.10.10.4-0.60.5
Time in open arm before self-admin0.60.82.8-1.30.20.6-0.5-0.3-0.81.7-0.5
Time in open arm after self-admin0.40.41.2-1.1-0.70.4-0.30.2-0.21.1-0.3
Bone: periosteal estimation1.53.67.0-2.1-2.62.0-2.01.91.61.11.4
Bone: periosteal perimeter0.40.92.3-1.2-1.50.8-0.80.70.41.00.3
Bone: post-yield work1.32.24.8-2.0-2.21.5-1.51.20.71.40.5
Progressive ratio test 1 active lever presses0.20.40.60.20.6-0.80.6-0.7-0.80.2-0.8
Progressive ratio test 1 breakpoint0.20.30.50.10.4-0.70.5-0.6-0.70.3-0.7
Progressive ratio test 1 inactive lever presses0.20.51.3-0.9-0.2-0.0-0.2-0.5-0.91.2-0.6
Progressive ratio test 2 active lever presses0.70.91.60.50.7-1.21.1-1.1-1.10.4-1.3
Progressive ratio test 2 breakpoint0.81.01.70.60.7-1.31.1-1.1-1.10.4-1.3
Progressive ratio test 2 inactive lever presses0.00.10.2-0.3-0.1-0.10.1-0.2-0.30.4-0.3
Incentive Sensitization - Responses0.10.30.60.20.3-0.70.7-0.6-0.60.4-0.8
Incentive Sensitization - Breakpoint0.20.40.80.40.4-0.80.8-0.7-0.70.3-0.9
Sum of active levers in priming session hrs 5-65.55.27.31.82.2-2.72.5-2.6-2.40.3-2.7
Progressive ratio0.00.10.20.10.2-0.30.4-0.4-0.40.3-0.5
Food seeking constrained by brief footshock4.25.311.8-3.4-2.82.3-2.81.60.52.60.4
Seeking ratio, punishment vs. effort1.02.23.8-2.0-1.81.6-1.81.40.91.00.9
Retroperitoneal fat weight0.20.71.61.11.2-0.90.8-0.7-0.4-0.7-0.2
Reaction time number correct0.10.30.50.20.5-0.60.6-0.7-0.7-0.3-0.3
Reaction time mean minus median0.42.86.80.5-1.40.8-0.92.12.6-1.92.0
Reaction time mean minus median AUC0.53.16.6-0.2-1.81.2-1.42.32.6-1.32.1
Reaction time num false alarms0.50.81.50.0-0.90.8-0.81.11.2-0.81.1
Reaction time num false alarms AUC0.41.01.5-0.6-1.21.1-1.11.11.1-0.11.0
Reaction time trials correct on left0.10.30.50.20.5-0.60.6-0.7-0.7-0.3-0.3
Reaction time trials on left0.10.40.60.30.6-0.70.7-0.7-0.8-0.4-0.3
Reaction time mean0.81.87.11.70.3-0.50.50.71.4-2.71.2
Reaction time mean AUC0.81.97.61.80.3-0.50.50.81.5-2.81.2
Median of all reaction times1.11.75.91.91.1-1.11.1-0.20.4-2.40.4
Reaction time omissions1.32.13.71.91.3-1.81.9-1.3-0.8-0.7-1.3
Reaction time false alarm rate0.50.61.3-0.2-0.80.8-0.81.01.1-0.30.9
Reaction time premature initiation rate2.53.89.03.02.0-2.32.2-1.3-0.5-2.4-0.2
Reaction time premature initiations1.33.97.92.82.0-2.42.3-1.5-0.9-2.3-0.3
Std. dev. reaction times0.62.05.11.2-0.50.1-0.11.42.1-2.31.6
Reaction time trials completed0.10.40.60.30.6-0.70.7-0.7-0.8-0.4-0.3
Reaction time trials AUC0.10.30.60.30.6-0.70.7-0.7-0.8-0.4-0.2
Run reversals in cocaine runway, females0.30.31.2-0.20.00.6-0.40.30.5-0.71.1
Run reversals in cocaine runway, males0.10.10.40.60.4-0.40.2-0.3-0.20.1-0.2
Latency to leave start box in cocaine runway0.91.32.1-1.4-1.11.4-1.51.00.80.80.9
Latency to leave start box in cocaine runway, F0.30.30.60.00.4-0.40.4-0.7-0.70.8-0.7
Latency to leave start box in cocaine runway, M4.13.96.7-2.6-1.82.5-2.61.71.21.31.4
Std. dev. time between licks in bursts0.30.61.21.10.6-0.90.9-0.5-0.2-0.4-1.0
Total sessions with >9 infusions0.10.10.1-0.3-0.2-0.20.2-0.3-0.40.3-0.2
Short access day 1 total inactive lever presses0.51.13.4-1.30.20.2-0.2-0.8-1.41.8-0.9
Short access day 10 total inactive lever presses0.10.51.3-0.8-0.50.8-1.10.40.20.30.8
Short access day 1 total infusions0.20.51.2-0.70.1-0.30.1-0.7-1.01.1-0.7
Short access day 10 total infusions0.50.91.60.30.9-1.11.0-1.2-1.20.1-0.9
Short access total infusions0.40.61.10.00.5-0.90.7-0.9-1.10.5-1.0
Short access day 1 locomotion1.11.82.61.11.6-1.51.6-1.6-1.3-0.4-0.9
Short access day 10 total locomotion0.20.93.31.30.7-0.60.8-0.20.3-1.80.6
Short access total locomotion0.50.81.30.91.0-1.01.1-0.9-0.7-0.7-0.3
One hour access (0.3 mA shock)0.40.41.20.60.3-0.90.8-0.5-0.50.0-1.1
Compulsive drug intake0.20.20.90.5-0.10.1-0.10.50.6-0.90.4
One hour access (shock baseline)0.41.12.20.20.5-1.10.8-1.2-1.31.0-1.5
Social response proportion0.81.02.01.11.2-0.90.9-0.9-0.70.3-1.4
Social responses0.40.51.9-0.5-0.70.4-0.50.2-0.01.4-0.8
Social time0.50.82.70.70.2-0.90.7-0.6-0.61.0-1.6
Soleus weight0.51.33.2-0.20.5-1.11.0-1.4-1.81.1-1.4
Bone: stiffness4.07.312.3-2.9-3.53.1-3.02.92.41.61.9
Tibialis anterior weight4.816.527.4-5.2-5.24.5-4.53.82.63.22.6
Time to tail flick, vehicle, before self-admin0.70.91.71.30.8-1.01.3-0.8-0.3-0.9-0.3
Time to tail flick, vehicle, after self-admin0.20.50.9-0.2-0.90.5-0.70.80.9-0.20.7
Time to tail flick, test, before self-admin0.30.30.6-0.8-0.60.8-0.50.60.40.10.6
Time to tail flick, test, after self-admin1.21.33.00.2-1.20.6-0.81.61.7-0.91.1
Delta time to tail flick, vehicle, before/after SA0.80.81.5-1.0-1.20.9-1.20.90.70.70.3
Delta time to tail flick, test, before/after SA0.30.41.31.20.1-0.70.40.30.6-0.90.0
Tibia length0.20.51.6-1.2-0.70.4-0.3-0.1-0.51.2-0.0
Ambulatory time before self-admin0.82.66.6-2.6-1.21.8-1.80.7-0.02.30.2
Ambulatory time after self-admin2.13.37.0-2.6-1.62.5-2.01.30.81.71.3
Bone: tissue strength0.60.62.1-0.2-0.50.4-0.30.60.6-1.21.5
Total heroin consumption1.61.92.91.21.2-1.71.4-1.6-1.40.1-1.7
Bone: trabecular number0.81.52.3-0.9-1.51.3-1.41.51.31.00.2
Bone: trabecular spacing0.40.61.8-0.3-0.60.6-0.70.80.9-0.71.4
Bone: trabecular thickness0.10.10.50.30.5-0.00.2-0.2-0.10.4-0.7
Bone: trabecular tissue density2.95.18.1-2.8-2.42.8-2.82.11.51.81.3
Water consumed over 24 hours0.91.82.8-1.7-1.61.6-1.61.20.81.20.8
Number of responses in last shaping day1.62.14.1-0.80.4-0.90.9-1.6-2.01.9-2.0