Cbr3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	gene expression	Cbr3	0.08	0.05	3.2e-04	0.03	0.05	0.04	0.04	1.7e-03	1.4e-04	2.7e-04	2.3e-04
2	Adipose	gene expression	Cbr3	0.23	0.1	0.0e+00	0.2	0.18	0.19	0.19	8.9e-22	5.6e-20	1.5e-20	2.3e-20
3	Adipose	mRNA stability	Cbr3	0.06	0.04	2.6e-05	0.02	0.03	0.03	0.03	1.3e-03	1.7e-04	3.2e-04	7.5e-04
4	PL	gene expression	Cbr3	0.1	0.06	8.3e-06	0.04	0.06	0.05	0.05	9.0e-05	5.0e-07	1.6e-06	2.1e-06
5	Liver	gene expression	Cbr3	0.04	0.03	8.8e-04	0	0.01	0.01	0	1.1e-01	6.3e-02	6.3e-02	1.7e-01
6	Brain	gene expression	Cbr3	0.26	0.1	0.0e+00	0.12	0.22	0.22	0.23	2.0e-11	5.4e-20	5.0e-20	6.9e-21
7	OFC	gene expression	Cbr3	0.33	0.15	2.0e-04	0.01	0.11	0.01	0.07	1.7e-01	1.4e-03	2.0e-01	1.1e-02
8	NAcc	gene expression	Cbr3	0.32	0.1	0.0e+00	0.19	0.25	0.24	0.21	2.2e-28	5.5e-37	1.2e-36	1.2e-31

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8
Bone: apparent density	0.1	0.2	0.8	-0.9	-0.0	0.4	0.6	-0.5	-0.2	-0.1	-0.2
Area under the delay curve	1.0	1.2	3.2	0.1	0.8	-0.1	1.8	0.6	1.0	1.2	1.6
BMI with tail	0.3	1.1	2.4	-1.6	0.9	-0.8	1.5	-0.6	1.0	1.0	0.7
BMI without tail	0.1	0.2	0.9	-0.7	-0.2	0.5	1.0	-0.2	0.2	0.2	0.1
Body weight	0.1	0.5	1.5	-0.0	0.1	-0.7	0.7	0.5	0.7	1.2	0.7
Weight adjusted by age	0.3	0.4	1.4	1.1	-0.6	0.2	-0.1	1.2	0.0	0.5	0.3
Bone surface	2.6	4.7	9.1	-2.2	3.0	-2.5	1.8	-1.1	2.5	1.9	1.7
Bone volume	1.4	2.5	4.4	-1.8	2.1	-1.7	1.6	-1.0	1.7	1.3	1.1
Breakpoint value in progressive ratio session	0.2	0.2	0.6	0.3	0.6	-0.8	-0.2	0.4	0.6	0.3	0.4
Number of licking bursts	0.3	0.5	1.5	-0.2	-0.9	1.2	0.1	-0.3	-0.8	-0.6	-0.6
Context. condit. distance diff. score	1.5	1.8	2.8	1.2	0.7	-1.5	0.4	1.5	1.6	1.7	1.5
Locomotion velocity, session 1	0.2	0.2	0.4	-0.2	0.1	0.1	-0.6	-0.5	-0.4	-0.4	-0.6
Locomotion distance, session 1	0.6	0.7	2.1	0.1	1.4	-1.3	-0.2	0.1	1.1	0.7	0.7
Locomotion velocity, session 2	0.2	0.3	1.1	0.3	0.4	-1.1	-0.2	0.3	0.3	0.7	0.4
Locomotion distance, session 2	0.3	0.4	0.8	0.3	0.6	-0.5	0.6	0.6	0.6	0.9	0.9
Locomotion velocity, session 3	1.1	1.3	3.4	-1.1	1.8	-1.8	-0.7	-1.3	0.7	0.2	-0.0
Locomotion distance, session 3	0.4	0.4	1.4	-1.2	0.7	-0.2	0.2	-1.2	0.2	-0.1	-0.1
Stereotopy head waving bouts, day 3	4.4	5.2	9.2	-1.5	-1.0	1.4	-2.2	-2.7	-2.5	-2.9	-3.0
Stereotopy head waving duration, day 3	2.6	3.1	5.5	-1.3	-0.7	0.9	-1.6	-2.2	-2.0	-2.2	-2.4
Locomotion velocity, session 7	0.5	0.6	1.1	1.0	-1.1	0.8	-0.8	0.6	-0.6	-0.4	-0.4
Locomotion distance, session 7	0.4	0.6	1.6	1.1	-0.7	0.4	0.3	1.3	0.1	0.6	0.7
Stereotopy head waving bouts, day 7	0.7	0.8	1.6	-0.7	0.6	-1.1	-1.3	-1.2	-0.0	-0.5	-0.9
Stereotopy head waving duration, day 7	0.7	0.9	3.7	-0.1	1.0	-1.9	-1.0	-0.4	0.9	0.4	-0.1
Locomotion velocity, session 8	1.1	1.3	4.2	-1.0	1.6	-2.1	-0.4	-1.0	0.8	0.7	0.2
Locomotion distance, session 8	1.6	2.3	4.1	1.1	1.0	-1.7	0.7	1.6	1.7	2.0	1.9
Degree of sensitization distance	0.8	0.8	2.6	1.6	-0.9	0.3	-0.3	1.6	-0.1	0.4	0.4
Degree of sensitization stereotypy	1.2	1.3	4.6	-0.5	1.5	-2.1	-0.1	-0.4	1.4	1.0	0.5
Conditioned locomotion	0.5	0.5	1.0	1.0	-0.9	0.6	-0.7	0.9	-0.6	-0.5	-0.3
Cocaine response after cond. corrected	0.4	0.5	1.2	1.1	0.0	-0.8	-1.0	0.8	0.4	0.3	0.2
Cocaine response after cond. not corrected	0.6	0.7	1.8	1.3	0.0	-0.8	-0.9	1.1	0.6	0.4	0.4
Cocaine response before conditioning	0.3	0.4	0.9	0.3	0.4	-0.3	0.6	0.4	1.0	0.7	0.8
Saline control response	0.6	0.8	2.4	-0.3	1.6	-1.3	0.0	-0.3	1.3	0.5	0.6
Bone: connectivity density	0.6	0.9	2.0	-1.4	1.2	-0.6	1.1	-0.8	0.8	0.6	0.5
Bone: cortical apparent density	0.0	0.0	0.0	0.0	-0.0	-0.0	0.2	0.1	0.2	0.1	0.0
Bone: cortical area	0.5	0.8	2.5	0.7	0.5	-1.6	-0.5	0.7	1.1	0.9	0.6
Bone: cortical porosity	0.2	0.3	0.6	0.6	-0.6	0.8	0.2	0.7	-0.3	-0.2	0.1
Bone: cortical porosity	0.2	0.2	0.5	0.7	-0.5	0.7	-0.0	0.7	-0.2	-0.2	0.1
Bone: cortical thickness	1.1	1.9	6.0	2.5	-1.6	-0.1	-1.6	1.9	-0.1	-0.1	-0.3
Bone: cortical thickness	0.2	0.2	0.7	0.9	-0.5	0.5	-0.4	0.5	-0.2	-0.3	-0.1
Bone: cortical tissue density	0.0	0.0	0.1	-0.1	-0.0	0.1	0.3	-0.1	0.1	0.0	-0.0
Condit. Reinf. active minus inactive responses	0.1	0.1	0.1	0.2	-0.2	0.3	-0.2	0.1	-0.3	-0.4	-0.1
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.5	0.7	-0.6	0.3	-0.7	0.3	-0.5	-0.5	-0.4
Condit. Reinf. active responses	0.1	0.1	0.2	0.3	0.3	-0.0	0.2	0.3	0.3	0.1	0.4
Condit. Reinf. inactive responses	0.0	0.0	0.1	-0.0	0.4	-0.1	-0.1	-0.1	0.4	-0.1	0.1
Incentive salience index mean	0.1	0.1	0.2	0.5	-0.2	0.2	0.0	0.5	-0.3	-0.0	0.2
Condit. Reinf. lever presses	0.2	0.3	1.1	1.0	-0.2	-0.1	-0.0	1.0	-0.0	0.4	0.5
Condit. Reinf. active minus inactive responses	1.8	2.4	3.9	0.3	1.7	-2.0	0.9	1.0	1.9	1.8	1.8
Condit. Reinf. active-inactive response ratio	1.1	1.2	2.3	0.0	1.0	-0.7	1.4	0.9	1.2	1.3	1.5
Condit. Reinf. active responses	1.0	1.4	4.0	-0.1	1.7	-2.0	-0.1	0.1	1.5	1.0	0.9
Condit. Reinf. inactive responses	0.5	0.7	2.3	-0.3	1.0	-1.5	-1.0	-0.7	0.8	0.2	-0.2
Condit. Reinf. lever presses	0.6	0.8	2.7	-0.2	1.2	-1.6	0.0	-0.1	1.1	0.9	0.5
Condit. Reinf. lever reinforcers received	1.2	1.7	4.8	-0.1	1.8	-2.2	0.0	0.1	1.7	1.3	1.0
Conditioned reinforcement - actives	0.6	1.0	3.0	1.6	-1.0	0.2	0.1	1.7	0.1	0.7	0.7
Conditioned reinforcement - inactives	2.3	3.4	7.9	2.8	-2.0	1.2	-2.4	1.8	-1.3	-1.4	-0.9
Conditioned locomotion	0.3	0.4	0.9	0.9	-0.3	0.5	-0.8	0.5	-0.2	-0.7	-0.4
Patch foraging indifference point 0 sec	1.0	1.8	5.3	1.9	-1.4	-0.1	-2.3	1.2	-0.9	-0.4	-1.0
Patch foraging indifference point AUC	0.8	1.2	3.8	0.1	1.3	-1.9	-0.0	0.4	1.4	1.2	0.8
Delay disc. indifference point, 0s delay	1.3	1.4	2.9	-0.1	0.9	-0.6	1.7	0.7	1.3	1.4	1.7
Delay disc. indifference point, 16s delay	0.2	0.2	0.7	-0.3	-0.0	0.6	0.8	-0.3	-0.2	-0.0	0.3
Delay disc. indifference point, 2s delay	0.6	0.6	2.3	-0.6	0.4	-0.1	1.5	0.0	0.7	0.9	1.1
Delay disc. indifference point, 24s delay	0.5	0.5	1.5	1.1	-0.3	0.4	0.6	1.2	0.3	0.3	0.9
Delay disc. indifference point, 4s delay	1.7	1.8	3.9	-0.2	1.2	-0.7	2.0	0.6	1.6	1.6	1.8
Delay disc. indifference point, 8s delay	0.6	0.7	1.5	0.7	0.4	-0.2	0.9	1.0	0.7	1.0	1.2
Indifference point function ln k	0.4	0.7	1.6	1.2	-0.8	1.2	-0.2	1.0	-0.4	-0.6	0.0
Indifference point function log k	0.4	0.7	1.6	1.2	-0.8	1.2	-0.2	1.0	-0.4	-0.6	0.0
Patch foraging total patch changes 0 sec	0.8	1.4	4.5	1.8	-1.2	-0.4	-2.1	1.1	-0.6	-0.3	-0.8
Patch foraging total patch changes 12 sec	0.4	0.5	1.7	0.3	0.5	-1.3	-1.2	-0.1	0.3	0.0	-0.4
Patch foraging total patch changes 18 sec	0.4	0.6	2.1	0.6	0.6	-1.5	-1.0	0.6	0.8	0.5	0.1
Patch foraging total patch changes 24 sec	0.9	1.5	3.3	0.7	1.2	-1.8	0.0	1.0	1.7	1.3	1.1
Patch foraging total patch changes 6 sec	0.7	1.1	5.4	0.8	-0.3	-1.0	-2.3	0.0	-0.4	-0.5	-1.1
Patch foraging time to switch 0 sec	0.2	0.4	1.1	-1.0	0.0	0.6	0.8	-1.0	-0.4	-0.1	-0.1
Patch foraging water rate 0 sec	0.2	0.5	1.1	-0.5	0.5	-1.0	-1.0	-0.8	0.2	-0.2	-0.6
Patch foraging water rate 12 sec	0.5	1.1	3.3	1.8	-1.1	-0.2	-1.1	1.6	0.2	0.4	-0.0
Patch foraging water rate 18 sec	0.1	0.1	0.6	-0.8	0.1	-0.0	0.5	-0.5	0.2	0.1	0.0
Patch foraging water rate 24 sec	0.9	1.2	2.9	1.3	0.2	-0.7	0.3	1.7	1.3	1.1	1.3
Patch foraging water rate 6 sec	0.2	0.2	0.5	0.7	0.3	-0.4	-0.3	0.7	0.6	0.4	0.4
Seeking ratio, delayed vs. immediate footshock	1.2	1.4	3.3	-1.0	-1.3	1.7	0.5	-0.9	-1.8	-0.9	-0.9
Distance traveled before self-admin	0.1	0.1	0.4	0.2	0.2	-0.4	-0.6	-0.4	0.2	-0.3	-0.2
Distance traveled after self-admin	0.4	0.4	1.9	-0.9	0.4	0.2	1.4	-0.3	0.3	0.5	0.5
Extensor digitorum longus weight	1.6	6.3	16.8	-4.1	3.4	-2.0	1.8	-3.4	1.7	0.6	0.3
Bone: elastic displacement	0.8	0.9	1.7	0.1	-1.0	1.3	-0.6	-0.3	-1.2	-1.2	-0.9
Bone: elastic work	0.4	0.5	1.0	0.0	-0.5	0.6	-0.8	-0.6	-0.8	-1.0	-0.9
Bone: endosteal estimation	2.0	4.5	9.6	-2.6	3.1	-1.9	2.2	-1.5	1.9	1.6	1.5
Bone: endosteal perimeter	1.6	3.5	6.9	-1.0	2.5	-2.6	1.2	-0.2	2.3	2.0	1.7
Epididymis fat weight	1.0	3.5	6.9	0.3	2.1	-2.4	1.1	0.9	2.6	2.2	2.1
Delta time in closed arm before/after self-admin	0.9	0.8	3.8	-1.0	0.2	0.2	2.0	-0.1	0.1	1.0	0.7
Delta time in open arm before/after self-admin	0.2	0.2	1.1	-0.5	0.3	-0.1	-0.4	-1.1	0.1	-0.4	-0.3
Diff in mean of infusions in LGA sessions	0.6	0.7	1.9	0.3	1.4	-1.4	-0.8	0.2	1.0	0.1	0.4
Delay discount exponential model param	0.9	1.0	2.7	-0.1	-0.7	0.1	-1.7	-0.6	-1.0	-1.1	-1.5
Extinction: sum of active levers before priming	0.6	0.6	1.7	0.9	0.6	-1.3	-0.7	0.6	0.8	0.6	0.4
Active lever presses in extinction session 6	2.3	2.3	6.5	0.8	-1.2	0.6	-2.5	0.1	-1.5	-1.9	-1.9
Bone: final force	0.3	0.4	1.5	-0.1	0.8	-1.2	-0.2	-0.0	0.8	0.6	0.3
Bone: final moment	0.3	0.5	1.6	0.0	0.9	-1.3	-0.2	0.0	0.8	0.6	0.3
Food consumed during 24 hour testing period	0.3	0.4	0.9	0.9	-0.9	0.0	-0.9	0.6	-0.3	-0.1	-0.4
Glucose	2.0	3.1	7.3	-2.0	2.7	-2.4	0.6	-1.6	1.8	1.0	0.7
Heart weight	0.2	0.3	1.6	-0.3	-0.0	0.3	1.3	0.1	0.0	0.4	0.5
Delay discount hyperbolic model param	1.1	1.2	3.1	-0.0	-0.8	0.2	-1.8	-0.6	-1.1	-1.3	-1.6
Intermittent access intake day 1-15 change	0.6	1.2	1.9	1.2	-1.2	1.0	-1.4	0.3	-0.9	-1.2	-1.0
Intermittent access intake escalation	0.5	1.1	1.7	1.0	-1.0	1.2	-1.3	0.1	-1.0	-1.3	-1.1
Intermittent access intake escalation 2	0.4	0.4	1.4	0.9	-0.2	0.2	-1.2	0.2	-0.3	-0.8	-0.5
Intermitt. access day 1 inactive lever presses	0.4	1.5	3.5	1.9	-1.4	1.1	-1.1	1.5	-0.9	-0.7	-0.5
Intermitt. access day 15 inactive lever presses	0.6	1.3	4.4	2.1	-0.3	0.1	-1.7	1.3	-0.2	-0.9	-0.2
Intermitt. access escalation Index	0.1	0.2	0.5	0.5	-0.4	0.5	-0.1	0.7	-0.1	-0.2	-0.0
Intermittent access day 1 total infusions	0.6	1.0	3.1	1.8	-1.2	0.4	-0.8	1.5	-0.3	0.0	0.2
Intermittent access day 15 total infusions	1.9	2.9	5.9	2.4	-1.8	1.5	-2.2	1.3	-1.3	-1.5	-1.0
Intermittent access terminal intake (last 3 days)	1.6	2.2	6.5	2.5	-1.2	1.1	-1.9	1.6	-0.8	-1.1	-0.5
Intermittent access total infusions	1.6	1.9	4.9	2.2	-1.6	1.1	-1.7	1.4	-1.0	-0.9	-0.6
Intermittent access day 1 locomotion	0.9	1.1	4.1	2.0	-1.1	0.8	-0.6	1.6	-0.4	0.1	0.2
Intermittent access day 15 total locomotion	0.8	1.4	5.2	2.3	-0.5	-0.4	-1.8	1.4	0.2	-0.2	-0.1
Intermittent access total locomotion	2.1	2.5	9.7	3.1	-1.1	0.4	-2.0	2.2	-0.4	-0.4	-0.2
Intermittent access standard deviation	0.5	1.1	4.1	0.7	-0.6	0.2	-2.0	-0.3	-1.0	-1.2	-1.2
Left kidney weight	0.9	4.0	12.5	3.0	-2.5	1.4	0.6	3.5	-0.2	0.8	1.2
Right kidney weight	0.9	4.1	11.3	3.1	-3.0	1.2	-0.6	3.4	-0.8	0.2	0.3
Cocaine induced anxiety	0.2	0.2	0.8	0.8	-0.5	-0.2	-0.9	0.3	0.1	-0.2	-0.1
Post-drug Anxiety	1.3	1.4	2.7	0.8	1.0	-1.6	0.1	1.0	1.6	1.3	1.2
Baseline Anxiety	0.9	1.0	2.9	-0.3	0.6	-0.6	1.7	0.6	0.8	1.5	1.2
Tail length	0.7	2.9	5.9	2.4	-2.2	1.5	-1.8	1.5	-1.4	-1.3	-0.9
Length with tail	0.2	0.8	3.0	1.7	-0.8	-0.0	-0.5	1.5	-0.0	0.4	0.3
Length without tail	0.2	0.5	1.4	0.4	0.7	-1.2	-0.1	0.6	0.7	0.9	0.5
Times rat made contact with spout	4.4	5.0	9.7	3.1	-2.9	2.2	-2.4	2.0	-1.6	-1.7	-1.3
Lifetime Intake	1.1	1.3	2.2	1.4	-1.5	1.3	-1.1	0.9	-1.2	-0.9	-0.7
Liver weight, left	2.3	3.9	9.7	2.3	-3.1	2.4	-0.7	2.1	-1.8	-1.1	-0.7
Liver weight, right	1.6	2.7	6.0	0.7	-2.4	2.5	-0.8	0.5	-2.2	-1.4	-1.4
Locomotor activity	0.8	1.3	4.3	2.1	-0.9	0.3	-0.2	2.1	0.3	0.7	0.6
Locomotor testing distance	0.4	0.6	1.8	1.4	-1.0	0.3	-1.0	1.0	-0.3	0.1	-0.3
Locomotor testing rearing	0.2	0.4	0.9	0.9	-0.2	-0.0	0.3	0.9	0.6	0.7	0.6
Locomotion in novel chamber	0.1	0.2	0.6	0.7	-0.2	0.0	-0.5	0.6	0.2	-0.2	0.0
Locomotion in novel chamber post-restriction	0.4	0.7	2.4	-1.2	0.1	0.7	0.3	-1.5	-0.6	-0.8	-0.6
Fecal boli incidents, locomotor time 1	1.1	1.7	3.7	0.7	0.2	-0.7	1.7	1.1	1.3	1.7	1.9
Change in fecal boli incidents, locomotor task	1.2	1.1	2.6	1.2	-0.8	1.6	-0.8	0.9	-0.9	-1.2	-0.8
Time >=10cm from walls, locomotor time 1	0.3	0.3	0.8	0.9	-0.1	0.1	-0.9	0.5	-0.4	-0.4	-0.5
Bouts of movement, locomotor time 1	0.0	0.0	0.2	-0.2	0.1	-0.2	-0.2	-0.4	-0.0	-0.1	-0.1
Total resting periods, locomotor time 1	0.0	0.0	0.1	0.1	0.2	-0.4	-0.2	-0.2	0.3	0.0	0.1
Rest time, locomotor task time 1	3.0	3.7	6.6	-0.0	1.9	-1.8	2.1	0.9	2.3	2.5	2.6
Distance moved, locomotor task time 1	2.7	4.0	7.4	-0.5	-1.8	2.3	-1.6	-1.3	-2.3	-2.7	-2.5
Vertical activity count, locomotor time 1	0.6	1.5	3.1	-0.5	-1.0	0.6	-1.4	-1.3	-1.4	-1.3	-1.8
Time >=10cm from walls, locomotor time 2	0.3	0.5	1.6	-1.2	0.4	0.3	0.3	-1.3	-0.3	-0.5	-0.5
Bouts of movement, locomotor time 2	1.9	3.0	5.9	-0.1	2.4	-2.2	1.0	0.4	2.3	1.8	1.9
Total resting periods, locomotor time 2	1.4	2.5	4.7	0.5	2.0	-1.9	0.8	1.0	2.2	1.6	1.8
Rest time, locomotor task time 2	1.1	1.4	2.8	1.4	0.6	-1.2	-0.0	1.7	1.3	1.2	1.3
Distance moved, locomotor task time 2	2.4	2.9	5.1	-1.9	-0.7	2.0	-0.0	-2.3	-1.7	-2.0	-1.8
Vertical activity count, locomotor time 2	0.8	1.1	4.3	-1.8	0.2	0.4	0.4	-2.1	-0.6	-0.5	-0.8
Light reinforcement 1	0.5	1.2	2.5	-0.4	1.0	-0.8	1.6	0.3	1.2	1.5	1.2
Light reinforcement 2	2.9	4.4	7.7	-1.7	2.8	-2.5	2.1	-0.8	2.3	2.2	1.9
Bone: marrow area	2.2	4.9	10.6	-2.6	3.3	-2.1	2.3	-1.5	2.0	1.8	1.6
Bone: maximum diameter	1.0	1.9	5.6	-0.3	1.7	-2.4	0.4	0.1	1.7	1.6	1.2
Bone: maximum force	0.1	0.2	0.6	-0.5	0.6	-0.8	-0.3	-0.6	0.3	0.1	-0.3
Bone: maximum moment	0.1	0.2	0.8	-0.4	0.7	-0.9	-0.2	-0.4	0.5	0.2	-0.1
Mean time between licks in bursts	0.6	1.5	3.6	1.1	-1.9	1.6	-1.0	0.6	-1.3	-1.0	-0.8
Mean num. licks in bursts	0.7	1.1	3.1	1.8	-0.7	0.1	-1.8	1.1	-0.2	-0.7	-0.5
Cd content in liver	1.0	1.1	3.2	-1.8	0.3	0.8	0.3	-1.8	-0.7	-1.0	-0.8
Co content in liver	0.8	1.0	2.0	-0.1	0.8	-0.7	1.4	0.6	1.1	1.3	1.3
Cu content in liver	0.2	0.2	0.5	0.6	-0.7	0.4	-0.7	0.2	-0.3	-0.4	-0.4
Fe content in liver	0.8	0.9	3.0	0.5	-0.6	0.0	-1.7	-0.3	-0.9	-1.1	-1.3
K content in liver	0.2	0.2	0.7	-0.8	0.3	-0.3	0.7	-0.6	0.0	0.4	0.1
Mg content in liver	0.3	0.3	0.8	-0.9	0.5	-0.2	0.8	-0.6	0.2	0.3	0.2
Mn content in liver	0.9	1.0	1.9	-0.2	1.1	-1.1	0.9	0.2	1.4	1.3	1.1
Na content in liver	1.9	2.0	4.6	-1.1	2.2	-2.1	0.6	-0.8	1.6	1.1	0.9
Rb content in liver	0.2	0.2	0.7	0.4	-0.8	0.6	0.3	0.5	-0.4	-0.0	-0.0
Se content in liver	1.3	1.6	2.4	0.4	-1.3	1.2	-1.4	-0.4	-1.5	-1.5	-1.6
Sr content in liver	0.4	0.3	0.8	0.9	-0.8	0.6	0.1	0.9	-0.3	0.1	0.2
Zn content in liver	0.1	0.1	0.2	-0.1	-0.3	0.2	-0.3	-0.3	-0.4	-0.2	-0.4
Bone: minimum diameter	1.6	3.0	6.3	-2.1	2.5	-2.2	0.8	-1.7	1.7	1.0	0.8
Time in familiar zone, hab. session 1	1.0	1.0	1.9	0.5	0.6	-1.1	0.7	0.9	1.2	1.4	1.3
Time in novel zone, hab. session 1	2.4	2.4	4.3	-1.7	-0.3	1.6	-0.3	-2.1	-1.4	-2.0	-1.7
Total zone transitions, hab. session 1	0.8	1.1	3.4	1.7	-0.4	-0.4	-0.2	1.8	0.7	1.0	1.0
Total locomotion distance, hab. session 1	0.4	0.6	1.8	1.3	-0.9	0.4	-0.3	1.3	-0.1	0.2	0.2
Locomotion velocity, hab. session 1	0.4	0.6	1.8	1.3	-0.9	0.4	-0.3	1.3	-0.2	0.2	0.2
Time in familiar zone, hab. session 2	2.1	2.2	3.7	-0.1	1.7	-1.2	1.7	0.6	1.9	1.6	1.9
Time in novel zone, hab. session 2	1.9	1.9	3.4	-0.3	-1.5	1.4	-1.1	-0.8	-1.8	-1.6	-1.7
Total zone transitions, hab. session 2	1.8	2.4	4.4	1.4	0.6	-1.0	1.0	2.1	1.5	1.9	2.1
Total locomotion distance, hab. session 2	1.1	1.4	4.4	1.6	-0.4	0.2	0.8	2.1	0.6	1.1	1.4
Locomotion velocity, hab. session 2	1.0	1.4	4.1	1.5	-0.3	0.0	0.8	2.0	0.6	1.3	1.4
Novel to familiar place preference ratio	1.0	1.1	1.6	-0.9	-0.8	1.2	-0.3	-1.2	-1.3	-1.1	-1.2
Novelty place preference	1.1	1.1	2.0	-1.4	-0.5	1.1	0.1	-1.4	-1.2	-1.0	-1.1
Time in novel zone, NPP test	0.9	1.0	2.0	-1.4	-0.3	1.0	0.2	-1.4	-0.9	-0.9	-0.9
Total zone transitions, NPP test	0.8	1.2	1.8	1.0	0.8	-1.1	0.3	1.3	1.2	1.2	1.3
Total locomotion distance, NPP test	0.1	0.1	0.3	0.3	-0.2	0.2	0.3	0.5	-0.1	0.2	0.3
Locomotion velocity, NPP test	0.1	0.1	0.4	0.5	-0.3	0.2	0.2	0.6	-0.2	0.3	0.3
Intraocular pressure	0.6	0.9	1.8	-1.1	-0.4	1.2	0.0	-1.4	-0.8	-1.1	-1.0
Delta distance traveled before/after self-admin	1.8	1.9	7.1	-0.7	0.5	0.0	2.7	0.8	1.0	1.7	1.7
Delta ambulatory time before/after self-admin	2.0	2.5	7.9	-0.6	0.5	-0.4	2.8	0.9	1.3	2.1	2.0
Parametrial fat weight	2.3	5.3	14.3	-3.8	2.4	-1.7	2.8	-2.4	1.3	1.9	0.9
Pavlov. Cond. lever latency	0.0	0.1	0.2	-0.4	-0.1	0.1	0.3	-0.3	-0.1	0.1	-0.1
Pavlov. Cond. magazine entry latency	0.3	0.4	0.8	0.5	-0.8	0.8	-0.4	0.2	-0.9	-0.6	-0.5
Pavlov. Cond. change in total contacts	0.1	0.1	0.4	0.5	-0.2	-0.2	0.3	0.6	0.2	0.4	0.4
Pavlov. Cond. index score	0.1	0.1	0.2	0.3	-0.4	0.2	-0.3	0.1	-0.5	-0.2	-0.2
Pavlov. Cond. latency score	0.1	0.1	0.2	0.3	-0.4	0.3	-0.2	0.2	-0.4	-0.2	-0.2
Pavlov. Cond. lever contacts	0.1	0.1	0.4	0.5	0.0	-0.3	-0.6	0.2	0.0	-0.1	-0.1
Pavlov. Cond. magazine entry number	0.2	0.3	0.7	0.1	0.5	-0.8	0.1	0.3	0.9	0.6	0.5
Pavlov. Cond. intertrial magazine entries	1.1	1.3	3.3	-1.2	1.2	-0.6	-1.1	-1.8	0.1	-1.3	-1.1
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.1	0.2	0.1	-0.3	0.2	-0.2	0.0	-0.4	-0.2	-0.2
Pavlov. Cond. response bias	0.1	0.2	0.3	0.4	-0.5	0.4	-0.5	0.1	-0.5	-0.5	-0.4
Pavlov. Cond. lever latency	1.3	1.7	4.3	0.1	-1.5	2.1	-0.6	-0.2	-1.7	-1.6	-1.2
Pavlov. Cond. magazine entry latency	0.4	0.5	0.9	1.0	0.4	-0.8	-0.1	0.8	0.8	0.7	0.7
Pavlov. Cond. change in total contacts	1.1	1.8	3.5	-0.3	1.4	-1.9	1.0	0.2	1.7	1.7	1.4
Pavlov. Cond. index score	0.5	0.7	2.0	0.7	0.7	-1.4	-0.3	0.5	1.1	0.9	0.7
Pavlov. Cond. latency score	0.6	0.8	1.4	0.9	0.6	-1.2	-0.1	0.8	1.1	0.9	0.8
Pavlov. Cond. lever contacts	1.3	1.8	4.2	-0.3	1.6	-2.1	0.7	0.0	1.8	1.5	1.2
Pavlov. Cond. magazine entry number	0.5	0.6	0.9	-0.3	-0.7	0.8	-0.6	-0.5	-1.0	-1.0	-0.9
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.2	-0.4	0.4	-0.4	-0.3	-0.5	0.1	-0.2	-0.2
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	2.1	0.8	0.7	-1.5	-0.2	0.6	1.2	1.0	0.8
Pavlov. Cond. response bias	1.1	1.5	4.0	-0.2	1.4	-2.0	0.4	0.0	1.6	1.4	1.0
Time in closed arm before self-admin	0.5	0.7	1.4	-0.3	1.2	-0.7	0.9	0.0	1.1	0.7	0.9
Time in closed arm after self-admin	3.2	3.5	13.8	-1.9	1.2	-0.0	3.7	-0.2	1.2	2.0	1.9
Time in open arm before self-admin	0.1	0.1	0.4	0.1	-0.2	-0.3	0.5	0.3	-0.0	0.6	0.3
Time in open arm after self-admin	0.5	0.5	2.1	0.3	0.3	-0.9	-1.4	-0.8	0.2	-0.4	-0.5
Bone: periosteal estimation	0.9	1.9	4.1	-1.2	2.0	-2.0	0.7	-0.7	1.6	1.2	1.0
Bone: periosteal perimeter	0.9	1.5	4.7	0.0	1.3	-2.2	0.1	0.2	1.6	1.4	1.0
Bone: post-yield work	0.2	0.4	1.0	-0.5	0.6	-1.0	-0.5	-0.7	0.5	0.1	-0.3
Progressive ratio test 1 active lever presses	1.2	1.5	3.7	1.7	-1.8	1.0	-0.4	1.9	-0.8	-0.1	-0.0
Progressive ratio test 1 breakpoint	1.1	1.4	3.7	1.7	-1.7	0.9	-0.4	1.9	-0.7	-0.0	0.1
Progressive ratio test 1 inactive lever presses	2.1	3.1	5.1	1.8	-2.3	2.0	-1.6	1.4	-1.8	-1.7	-1.3
Progressive ratio test 2 active lever presses	2.8	3.3	5.6	2.4	-2.3	1.6	-2.1	1.6	-1.5	-1.5	-1.1
Progressive ratio test 2 breakpoint	2.8	3.2	5.2	2.3	-2.2	1.6	-2.1	1.6	-1.5	-1.5	-1.1
Progressive ratio test 2 inactive lever presses	2.2	3.6	12.4	3.5	-1.3	0.8	-2.6	2.4	-0.5	-1.3	-0.4
Incentive Sensitization - Responses	1.4	1.9	4.2	1.7	-1.3	1.1	-2.0	1.1	-0.8	-1.6	-1.0
Incentive Sensitization - Breakpoint	1.6	2.1	4.7	1.9	-1.2	1.1	-2.2	1.2	-0.8	-1.7	-1.0
Sum of active levers in priming session hrs 5-6	0.6	0.6	2.1	0.4	-0.3	-0.1	-1.5	-0.3	-0.8	-0.8	-1.1
Progressive ratio	0.2	0.4	0.7	-0.6	0.1	0.1	-0.6	-0.8	-0.5	-0.7	-0.7
Food seeking constrained by brief footshock	0.6	0.8	2.2	0.4	-1.5	0.9	-0.8	0.2	-1.0	-0.5	-1.0
Seeking ratio, punishment vs. effort	0.3	0.4	1.0	0.5	-1.0	0.9	-0.3	0.4	-0.6	-0.3	-0.4
Retroperitoneal fat weight	1.3	5.4	8.8	-3.0	2.8	-2.1	2.8	-1.7	2.0	2.1	1.6
Reaction time number correct	0.1	0.2	0.4	0.4	0.1	-0.7	-0.5	0.3	0.5	0.3	0.3
Reaction time mean minus median	0.2	0.5	1.3	1.2	-0.0	0.5	-1.0	0.6	-0.1	-0.9	-0.4
Reaction time mean minus median AUC	0.2	0.4	1.4	1.2	0.4	-0.2	-1.1	0.6	0.3	-0.6	-0.1
Reaction time num false alarms	1.5	2.1	5.2	0.9	-2.3	1.6	-1.2	0.1	-1.8	-1.2	-1.4
Reaction time num false alarms AUC	0.9	1.4	4.1	0.9	-2.0	1.4	-0.8	0.4	-1.4	-0.7	-1.0
Reaction time trials correct on left	0.1	0.2	0.4	0.4	0.1	-0.7	-0.5	0.3	0.5	0.3	0.3
Reaction time trials on left	0.1	0.2	0.5	0.4	0.2	-0.7	-0.5	0.2	0.5	0.3	0.3
Reaction time mean	0.7	1.0	2.0	-0.9	-0.2	1.3	-0.2	-1.2	-1.1	-1.4	-1.1
Reaction time mean AUC	0.6	0.9	2.1	-0.4	-0.2	1.1	-0.6	-0.9	-1.0	-1.4	-1.1
Median of all reaction times	1.0	1.4	2.5	-1.5	-0.1	1.4	0.3	-1.6	-1.2	-1.3	-1.1
Reaction time omissions	0.1	0.2	0.5	0.0	0.5	0.7	0.0	-0.4	-0.1	-0.6	-0.0
Reaction time false alarm rate	1.1	1.6	4.0	0.6	-2.0	1.7	-0.6	0.1	-1.7	-0.9	-1.1
Reaction time premature initiation rate	1.3	1.8	3.5	-1.0	1.9	-1.2	1.6	-0.4	1.6	1.3	1.3
Reaction time premature initiations	0.9	1.5	3.0	-0.4	1.7	-1.5	0.9	-0.1	1.7	1.2	1.2
Std. dev. reaction times	0.5	0.8	1.9	0.7	-0.4	1.2	-1.1	-0.0	-0.8	-1.4	-1.0
Reaction time trials completed	0.1	0.2	0.5	0.4	0.2	-0.7	-0.5	0.2	0.5	0.3	0.3
Reaction time trials AUC	0.1	0.2	0.7	0.1	0.3	-0.8	-0.4	-0.0	0.6	0.3	0.2
Run reversals in cocaine runway, females	0.4	0.4	1.4	1.2	-0.2	0.6	-0.1	1.2	0.1	-0.4	0.3
Run reversals in cocaine runway, males	1.0	1.0	1.5	1.0	0.6	-1.2	0.0	1.2	1.2	1.0	1.0
Latency to leave start box in cocaine runway	0.2	0.3	0.9	-0.2	0.6	0.0	1.0	0.3	0.4	0.5	0.6
Latency to leave start box in cocaine runway, F	0.2	0.2	0.8	-0.5	0.1	0.9	0.9	-0.2	-0.2	-0.1	0.1
Latency to leave start box in cocaine runway, M	0.9	0.9	1.4	0.5	1.0	-1.2	0.4	0.9	1.0	1.1	1.0
Std. dev. time between licks in bursts	0.5	0.7	2.0	1.3	-0.7	0.2	-1.4	0.7	-0.2	-0.7	-0.5
Total sessions with >9 infusions	0.9	1.0	2.4	0.0	-1.2	1.5	-0.3	-0.3	-1.4	-1.1	-1.0
Short access day 1 total inactive lever presses	2.2	2.8	5.1	0.9	-1.6	2.0	-1.9	-0.3	-1.8	-2.3	-1.8
Short access day 10 total inactive lever presses	0.6	1.5	4.3	-0.4	-0.3	1.4	-1.1	-0.9	-1.3	-2.1	-1.3
Short access day 1 total infusions	1.5	2.0	3.8	-0.5	-1.8	2.0	-0.4	-0.6	-1.9	-1.5	-1.5
Short access day 10 total infusions	0.9	1.1	2.5	-0.5	-1.1	1.6	-0.1	-0.8	-1.6	-1.0	-1.0
Short access total infusions	0.9	1.1	2.6	-0.2	-1.2	1.6	-0.2	-0.3	-1.6	-1.0	-1.0
Short access day 1 locomotion	2.0	2.5	6.0	0.2	-1.8	2.4	-0.8	-0.6	-1.9	-1.9	-1.6
Short access day 10 total locomotion	0.2	0.4	0.9	0.4	1.0	-0.3	0.6	0.4	0.8	0.6	0.7
Short access total locomotion	0.1	0.1	0.4	0.5	0.1	0.7	0.0	0.0	-0.1	-0.3	-0.0
One hour access (0.3 mA shock)	1.6	1.9	6.1	2.5	-1.3	0.7	-1.7	1.5	-0.4	-1.0	-0.2
Compulsive drug intake	0.6	0.7	1.2	-0.7	1.1	-0.8	1.0	-0.4	1.0	0.7	0.8
One hour access (shock baseline)	2.2	3.4	7.0	2.5	-2.0	1.3	-2.6	1.2	-1.4	-1.8	-1.3
Social response proportion	0.2	0.2	0.9	0.8	-0.3	0.4	0.0	0.9	-0.1	0.1	-0.0
Social responses	0.4	0.5	1.7	0.8	-0.2	-0.2	0.5	1.3	0.4	1.0	0.6
Social time	0.2	0.3	0.7	0.3	0.5	-0.6	0.2	0.3	0.8	0.6	0.6
Soleus weight	1.0	2.9	5.8	-1.0	2.4	-2.2	1.3	-0.5	2.0	1.8	1.5
Bone: stiffness	0.0	0.1	0.2	0.2	-0.1	-0.5	-0.4	0.0	0.2	0.2	-0.1
Tibialis anterior weight	3.0	10.2	29.2	-5.4	4.2	-2.3	2.2	-4.6	1.7	0.6	0.2
Time to tail flick, vehicle, before self-admin	3.5	3.6	5.8	0.3	-2.4	1.7	-2.0	-1.2	-2.1	-2.1	-2.4
Time to tail flick, vehicle, after self-admin	0.6	0.8	2.0	-0.7	1.2	-0.5	1.4	-0.1	0.9	0.6	1.0
Time to tail flick, test, before self-admin	0.5	0.5	1.5	0.5	-0.5	1.2	1.1	0.6	-0.2	0.2	0.4
Time to tail flick, test, after self-admin	0.9	0.9	2.2	0.6	0.1	-0.0	1.5	1.0	0.8	1.2	1.3
Delta time to tail flick, vehicle, before/after SA	2.7	2.6	4.7	-0.3	2.2	-1.3	1.8	0.9	1.9	1.5	2.1
Delta time to tail flick, test, before/after SA	0.1	0.1	0.2	0.3	0.1	-0.5	-0.1	0.1	0.3	0.3	0.3
Tibia length	0.0	0.1	0.2	0.3	-0.5	0.2	0.0	0.4	-0.3	-0.1	0.0
Ambulatory time before self-admin	0.3	0.4	1.0	-0.2	0.3	-0.3	-0.9	-1.0	0.1	-0.8	-0.6
Ambulatory time after self-admin	0.5	0.5	1.3	-1.1	0.6	-0.2	1.2	-0.7	0.6	0.5	0.4
Bone: tissue strength	0.2	0.2	0.5	0.6	-0.6	0.5	0.1	0.7	-0.2	-0.0	0.1
Total heroin consumption	1.2	1.5	4.2	1.9	0.1	-1.0	-0.5	2.0	0.9	1.0	0.9
Bone: trabecular number	0.1	0.2	0.6	-0.6	0.4	0.0	0.8	-0.1	0.2	0.3	0.3
Bone: trabecular spacing	1.2	1.5	4.9	2.2	-1.5	1.1	-0.3	1.9	-0.4	-0.2	0.3
Bone: trabecular thickness	0.4	0.5	1.8	-1.4	0.7	-0.6	0.4	-1.1	0.3	0.2	-0.1
Bone: trabecular tissue density	0.4	0.6	1.9	1.2	-0.8	0.2	0.4	1.4	0.3	0.7	0.7
Water consumed over 24 hours	0.2	0.3	1.0	1.0	-0.5	-0.1	-0.7	0.8	0.0	0.2	-0.1
Number of responses in last shaping day	0.7	0.8	2.0	1.0	-1.2	1.4	0.3	1.0	-0.6	-0.3	-0.0