Hub : Genes

Rps6ka4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose mRNA stability Rps6ka4 0.03 0.02 6.6e-03 0.01 0 -0 0 5.6e-02 8.8e-02 6.0e-01 2.3e-01
2 Liver mRNA stability Rps6ka4 0.06 0.04 3.8e-05 0.04 0.03 0.03 0.04 1.9e-05 3.0e-04 1.8e-04 5.9e-05
3 Adipose gene expression Rps6ka4 0.05 0.04 2.4e-03 0.01 0.01 0.01 0.01 2.4e-02 4.7e-02 3.2e-02 6.5e-02
4 OFC gene expression Rps6ka4 0.17 0.1 2.0e-03 0.06 0.08 0.06 0.07 1.4e-02 6.7e-03 1.3e-02 1.1e-02
5 Brain mRNA stability Rps6ka4 0.03 0.02 6.2e-03 0.01 0.02 0.01 0.01 3.6e-02 6.3e-03 4.0e-02 3.3e-02
6 NAcc gene expression Rps6ka4 0.15 0.07 0.0e+00 0.1 0.12 0.12 0.12 1.2e-15 1.3e-17 6.8e-18 8.2e-18
7 BLA gene expression Rps6ka4 0.44 0.16 7.4e-14 0.24 0.24 0.24 0.25 7.5e-13 3.3e-13 6.2e-13 2.1e-13
8 IC gene expression Rps6ka4 0.17 0.1 8.8e-04 0.08 0.06 0.05 0.08 2.8e-04 1.5e-03 3.6e-03 4.1e-04
9 PL gene expression Rps6ka4 0.17 0.08 4.6e-12 0.1 0.1 0.1 0.1 3.3e-11 2.9e-11 4.8e-11 9.6e-11
10 Brain gene expression Rps6ka4 0.08 0.05 1.5e-04 0.04 0.04 0.04 0.03 1.8e-04 2.3e-04 1.0e-04 4.5e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bone: apparent density0.91.53.2-0.9-0.90.80.5-0.71.81.81.71.31.2
Area under the delay curve0.40.51.5-0.00.1-0.10.10.40.90.90.81.11.2
BMI with tail3.712.924.5-2.3-2.22.71.7-1.75.04.94.93.64.4
BMI without tail1.54.68.2-1.5-1.51.61.4-0.62.82.72.62.62.9
Body weight3.515.123.6-3.7-3.63.83.2-2.84.94.64.33.83.8
Weight adjusted by age0.81.32.9-1.7-1.41.41.5-1.70.70.50.30.2-0.1
Bone surface4.17.510.5-3.0-3.13.02.3-3.23.23.02.71.61.5
Bone volume1.73.05.1-1.8-1.81.71.0-2.12.32.12.10.80.9
Breakpoint value in progressive ratio session2.22.75.5-2.0-2.02.22.0-2.31.51.20.60.60.3
Number of licking bursts0.10.20.5-0.6-0.60.60.5-0.70.20.1-0.0-0.0-0.1
Context. condit. distance diff. score1.01.22.81.61.6-1.4-1.31.7-0.4-0.2-0.00.10.4
Locomotion velocity, session 10.40.41.5-0.1-0.10.00.10.50.70.80.61.20.9
Locomotion distance, session 11.31.63.3-0.8-0.80.50.40.11.71.81.81.81.5
Locomotion velocity, session 22.22.53.6-1.9-1.91.71.6-1.41.71.61.41.41.1
Locomotion distance, session 20.81.12.4-1.0-1.00.60.8-0.11.31.31.11.51.1
Locomotion velocity, session 31.82.04.90.50.5-0.8-1.01.21.51.82.21.61.9
Locomotion distance, session 30.20.20.60.20.2-0.1-0.20.40.50.50.80.50.7
Stereotopy head waving bouts, day 31.92.24.20.90.8-1.2-1.21.61.31.72.11.52.0
Stereotopy head waving duration, day 30.60.71.30.90.8-1.2-1.21.20.30.60.90.40.7
Locomotion velocity, session 70.91.02.70.70.6-0.9-1.01.00.81.01.70.71.2
Locomotion distance, session 70.60.81.70.20.2-0.4-0.20.90.91.11.31.31.3
Stereotopy head waving bouts, day 70.10.10.30.10.1-0.0-0.4-0.30.40.40.6-0.20.3
Stereotopy head waving duration, day 70.60.71.8-1.0-1.01.00.7-1.30.80.60.50.00.2
Locomotion velocity, session 81.01.22.6-1.1-1.11.11.2-0.41.11.10.61.61.1
Locomotion distance, session 80.71.12.20.50.5-0.5-0.80.91.11.31.51.21.4
Degree of sensitization distance0.60.61.40.00.0-0.3-0.30.60.91.11.21.11.2
Degree of sensitization stereotypy0.40.41.5-0.7-0.70.80.3-1.20.50.40.3-0.3-0.0
Conditioned locomotion1.11.32.3-1.3-1.51.31.3-1.01.01.00.61.00.8
Cocaine response after cond. corrected1.01.23.61.41.3-1.5-1.21.9-0.20.10.20.60.6
Cocaine response after cond. not corrected0.70.82.41.21.1-1.2-1.01.50.10.30.40.60.6
Cocaine response before conditioning0.60.72.3-1.0-0.91.20.9-1.50.30.00.1-0.5-0.6
Saline control response3.14.17.2-2.5-2.52.52.7-2.11.81.51.21.41.2
Bone: connectivity density2.43.85.9-2.0-2.02.01.6-1.82.42.32.01.61.3
Bone: cortical apparent density0.40.51.3-0.3-0.30.30.5-0.4-0.9-1.1-1.0-0.8-0.9
Bone: cortical area0.50.81.6-1.2-1.11.00.8-1.30.80.60.70.20.4
Bone: cortical porosity0.10.10.2-0.4-0.50.30.4-0.40.10.00.1-0.00.3
Bone: cortical porosity0.40.40.8-0.8-0.90.80.8-0.70.50.40.40.40.5
Bone: cortical thickness1.72.87.0-2.4-2.32.32.7-2.00.40.0-0.30.50.1
Bone: cortical thickness0.40.51.2-0.7-0.70.71.1-0.00.50.30.21.10.7
Bone: cortical tissue density0.40.61.2-0.4-0.50.50.7-0.6-0.9-1.1-1.0-0.8-0.9
Condit. Reinf. active minus inactive responses0.10.10.3-0.4-0.40.50.5-0.30.20.20.30.20.5
Condit. Reinf. active-inactive response ratio0.20.20.4-0.2-0.20.40.4-0.3-0.5-0.6-0.5-0.5-0.2
Condit. Reinf. active responses0.10.10.3-0.1-0.10.1-0.1-0.10.30.30.60.10.4
Condit. Reinf. inactive responses0.30.41.20.40.4-0.5-0.70.40.60.71.10.30.5
Incentive salience index mean0.40.51.0-0.5-0.60.60.5-0.40.80.81.00.61.0
Condit. Reinf. lever presses0.60.81.8-0.7-0.70.80.5-0.81.21.21.30.50.9
Condit. Reinf. active minus inactive responses0.10.10.50.30.2-0.3-0.6-0.2-0.0-0.10.3-0.7-0.2
Condit. Reinf. active-inactive response ratio0.50.62.31.00.8-0.9-1.50.30.10.20.8-0.8-0.0
Condit. Reinf. active responses0.10.10.4-0.3-0.40.40.1-0.70.1-0.00.1-0.4-0.1
Condit. Reinf. inactive responses0.40.51.5-0.9-0.81.01.2-0.60.2-0.0-0.30.40.3
Condit. Reinf. lever presses1.31.84.1-1.6-1.71.61.1-2.01.41.21.10.20.3
Condit. Reinf. lever reinforcers received0.20.31.1-0.6-0.70.70.5-1.00.20.00.1-0.5-0.2
Conditioned reinforcement - actives0.20.41.6-0.1-0.00.2-0.5-1.0-0.1-0.20.1-1.3-0.9
Conditioned reinforcement - inactives2.13.15.02.02.1-1.9-2.20.8-1.5-1.3-1.3-2.2-1.8
Conditioned locomotion6.58.512.73.33.4-3.5-3.62.5-2.9-2.5-2.0-2.6-2.2
Patch foraging indifference point 0 sec0.00.00.10.00.10.0-0.10.0-0.1-0.2-0.1-0.30.1
Patch foraging indifference point AUC1.62.35.9-1.9-1.82.41.7-2.40.70.30.4-0.3-0.6
Delay disc. indifference point, 0s delay1.21.32.90.30.4-0.1-0.31.01.41.51.41.71.7
Delay disc. indifference point, 16s delay0.40.50.90.90.9-0.9-0.90.6-0.5-0.5-0.3-0.6-0.3
Delay disc. indifference point, 2s delay0.20.20.40.20.3-0.2-0.40.30.60.60.50.70.7
Delay disc. indifference point, 24s delay0.00.00.10.10.2-0.10.30.4-0.1-0.1-0.10.20.2
Delay disc. indifference point, 4s delay0.70.72.00.20.2-0.10.20.71.01.00.91.41.4
Delay disc. indifference point, 8s delay0.50.51.7-0.00.0-0.20.20.60.80.90.71.21.3
Indifference point function ln k4.17.117.63.63.5-3.7-3.14.2-1.6-1.1-0.9-0.00.5
Indifference point function log k4.17.117.63.63.5-3.7-3.14.2-1.6-1.1-0.9-0.00.5
Patch foraging total patch changes 0 sec0.00.00.1-0.00.00.10.10.1-0.2-0.4-0.3-0.20.1
Patch foraging total patch changes 12 sec3.24.18.7-2.7-2.52.92.6-2.61.71.31.00.80.5
Patch foraging total patch changes 18 sec0.50.82.1-1.0-0.81.41.0-1.40.60.30.6-0.20.1
Patch foraging total patch changes 24 sec1.11.94.2-1.9-1.72.01.9-1.90.90.50.30.30.2
Patch foraging total patch changes 6 sec0.91.32.0-1.3-1.21.41.3-0.91.21.01.01.11.1
Patch foraging time to switch 0 sec1.42.84.9-1.7-1.61.11.0-1.52.12.22.21.31.5
Patch foraging water rate 0 sec2.85.98.02.82.7-2.4-2.12.3-2.8-2.8-2.5-2.0-1.6
Patch foraging water rate 12 sec4.910.315.53.83.7-3.9-3.03.9-3.4-3.1-3.0-1.5-1.5
Patch foraging water rate 18 sec1.82.86.82.22.1-2.4-1.72.6-1.2-1.0-0.7-0.10.1
Patch foraging water rate 24 sec2.84.06.82.62.6-2.6-2.02.5-1.7-1.7-1.6-0.9-0.7
Patch foraging water rate 6 sec3.45.09.72.92.7-2.6-2.03.1-2.2-2.1-1.9-0.7-0.6
Seeking ratio, delayed vs. immediate footshock0.10.20.30.50.5-0.5-0.40.6-0.3-0.30.1-0.20.2
Distance traveled before self-admin0.50.72.0-1.0-0.91.00.6-1.40.90.80.60.0-0.1
Distance traveled after self-admin0.50.61.4-0.6-0.50.40.6-0.9-0.5-0.6-1.1-0.7-1.2
Extensor digitorum longus weight5.923.434.9-5.8-5.95.85.5-5.04.74.23.73.53.2
Bone: elastic displacement1.01.22.31.01.0-1.0-0.51.4-1.4-1.3-1.5-0.2-0.5
Bone: elastic work0.70.92.1-1.1-1.01.01.5-0.20.60.60.31.31.1
Bone: endosteal estimation1.22.56.01.21.3-1.3-1.91.31.51.92.41.01.8
Bone: endosteal perimeter1.12.35.31.41.4-1.5-2.31.11.21.62.20.41.3
Epididymis fat weight1.86.214.63.53.5-3.2-3.82.5-1.2-0.9-0.2-1.7-0.7
Delta time in closed arm before/after self-admin0.70.72.5-0.4-0.30.10.60.80.70.80.71.61.1
Delta time in open arm before/after self-admin0.60.62.4-0.5-0.40.90.4-1.5-0.1-0.3-0.4-1.1-1.0
Diff in mean of infusions in LGA sessions0.30.41.0-0.8-0.80.71.0-0.80.50.30.10.30.3
Delay discount exponential model param0.40.41.20.10.00.0-0.2-0.2-0.8-0.8-0.7-1.0-1.1
Extinction: sum of active levers before priming2.02.23.5-1.7-1.61.91.6-1.71.61.41.31.00.5
Active lever presses in extinction session 62.62.66.1-2.0-2.02.31.7-2.51.41.11.00.3-0.1
Bone: final force2.33.74.8-2.2-2.22.01.7-1.92.22.02.11.31.4
Bone: final moment2.13.54.5-2.1-2.11.91.7-1.92.12.02.01.31.4
Food consumed during 24 hour testing period0.50.71.7-0.2-0.20.20.1-0.7-0.9-1.0-1.2-1.1-1.3
Glucose1.62.65.52.22.1-2.0-2.32.30.20.50.90.60.7
Heart weight1.72.64.21.31.2-1.0-1.02.01.41.81.92.02.0
Delay discount hyperbolic model param0.40.51.30.10.00.0-0.2-0.2-0.9-0.9-0.9-1.0-1.1
Intermittent access intake day 1-15 change0.91.94.01.41.4-1.1-1.40.3-1.4-1.4-1.2-2.0-1.6
Intermittent access intake escalation0.81.74.11.21.2-1.0-1.30.1-1.4-1.3-1.1-2.0-1.7
Intermittent access intake escalation 21.41.63.71.11.1-1.1-1.30.1-1.3-1.3-1.1-1.9-1.7
Intermitt. access day 1 inactive lever presses0.10.40.60.30.4-0.4-0.40.1-0.8-0.7-0.7-0.8-0.8
Intermitt. access day 15 inactive lever presses1.02.04.51.61.6-2.0-2.10.8-1.1-1.0-0.5-1.5-1.2
Intermitt. access escalation Index1.82.64.12.02.0-1.8-1.72.0-1.6-1.4-1.4-0.8-0.6
Intermittent access day 1 total infusions1.62.67.11.91.9-2.0-2.71.70.50.81.50.21.0
Intermittent access day 15 total infusions3.04.411.92.82.8-2.7-3.41.7-1.1-0.8-0.1-1.8-0.9
Intermittent access terminal intake (last 3 days)2.53.310.62.62.5-2.3-3.31.4-0.3-0.00.6-1.3-0.3
Intermittent access total infusions2.42.88.82.32.2-2.2-3.01.60.10.41.1-0.60.3
Intermittent access day 1 locomotion1.31.74.71.71.7-1.8-2.21.50.20.50.9-0.00.6
Intermittent access day 15 total locomotion1.93.49.42.52.5-2.4-3.11.2-0.8-0.7-0.0-1.9-0.9
Intermittent access total locomotion3.94.714.33.03.0-2.9-3.81.7-0.6-0.30.5-1.6-0.4
Intermittent access standard deviation0.71.52.61.41.4-1.6-1.60.9-1.0-0.9-0.8-1.2-1.1
Left kidney weight0.31.33.21.51.7-1.4-1.81.30.10.30.7-0.10.5
Right kidney weight0.20.71.91.11.2-1.1-1.40.9-0.1-0.00.5-0.40.1
Cocaine induced anxiety0.10.10.4-0.2-0.20.10.0-0.60.0-0.1-0.0-0.4-0.5
Post-drug Anxiety0.40.40.9-0.9-0.90.70.6-0.90.60.60.30.20.1
Baseline Anxiety0.30.30.8-0.6-0.60.60.80.00.30.50.00.90.7
Tail length0.31.13.4-1.6-1.51.41.8-1.00.1-0.3-0.50.5-0.1
Length with tail1.35.810.1-3.2-3.13.03.2-2.32.01.61.32.01.3
Length without tail1.54.87.5-2.7-2.62.72.7-1.92.11.81.42.01.4
Times rat made contact with spout0.30.31.1-0.8-0.80.71.1-0.5-0.0-0.1-0.30.30.1
Lifetime Intake1.82.26.41.91.9-1.9-2.51.60.30.61.2-0.10.6
Liver weight, left0.50.92.41.21.3-1.1-1.11.5-0.00.20.40.40.7
Liver weight, right1.42.57.22.02.1-2.0-1.72.7-0.10.30.41.01.0
Locomotor activity1.42.25.01.92.0-1.8-1.32.2-1.3-1.1-1.1-0.3-0.4
Locomotor testing distance1.42.67.22.22.2-1.9-1.42.7-1.1-1.0-1.00.1-0.1
Locomotor testing rearing1.12.26.12.02.0-1.9-1.42.5-1.0-0.8-0.90.1-0.1
Locomotion in novel chamber3.34.28.52.82.6-2.6-2.92.1-1.5-1.2-0.8-1.5-0.9
Locomotion in novel chamber post-restriction1.93.25.72.22.2-2.1-2.41.6-1.6-1.5-1.0-1.5-1.1
Fecal boli incidents, locomotor time 10.20.20.9-0.2-0.20.4-0.1-1.00.20.00.1-0.8-0.7
Change in fecal boli incidents, locomotor task0.60.61.80.30.1-0.6-0.11.10.40.50.81.21.3
Time >=10cm from walls, locomotor time 10.60.72.00.60.7-0.9-1.40.10.60.71.4-0.40.2
Bouts of movement, locomotor time 12.02.23.7-1.2-1.31.11.6-1.9-1.0-1.3-1.7-1.6-1.9
Total resting periods, locomotor time 11.82.04.1-0.9-1.10.91.2-1.7-1.1-1.3-1.6-1.7-2.0
Rest time, locomotor task time 11.31.72.21.51.4-1.1-1.40.9-1.4-1.5-1.0-1.5-1.0
Distance moved, locomotor task time 10.50.82.0-0.5-0.30.40.3-0.11.21.40.91.21.3
Vertical activity count, locomotor time 10.30.71.51.01.2-1.2-1.11.20.00.30.20.30.5
Time >=10cm from walls, locomotor time 20.30.51.3-0.4-0.4-0.0-0.0-1.0-0.4-0.6-0.5-1.2-1.1
Bouts of movement, locomotor time 20.20.40.8-0.6-0.70.90.8-0.9-0.2-0.3-0.4-0.4-0.5
Total resting periods, locomotor time 20.10.20.4-0.3-0.40.60.4-0.6-0.2-0.3-0.4-0.4-0.5
Rest time, locomotor task time 21.31.73.81.81.8-1.6-1.91.8-0.5-0.40.2-0.50.1
Distance moved, locomotor task time 20.80.92.0-1.4-1.31.21.4-1.30.30.2-0.30.2-0.2
Vertical activity count, locomotor time 20.10.10.5-0.00.1-0.20.30.3-0.5-0.6-0.70.0-0.3
Light reinforcement 10.10.30.70.10.3-0.3-0.10.1-0.8-0.8-0.8-0.7-0.7
Light reinforcement 20.81.32.70.80.9-1.4-1.60.2-1.0-1.0-0.4-1.7-1.3
Bone: marrow area1.22.75.91.31.3-1.4-1.91.41.41.82.41.01.8
Bone: maximum diameter0.20.41.1-0.6-0.60.5-0.0-1.10.90.80.9-0.10.2
Bone: maximum force3.76.511.5-2.5-2.62.31.7-2.43.23.03.41.72.1
Bone: maximum moment3.45.910.2-2.4-2.42.21.6-2.23.02.93.21.72.0
Mean time between licks in bursts0.20.41.4-0.5-0.50.51.00.30.30.30.11.20.8
Mean num. licks in bursts0.10.20.40.50.5-0.4-0.20.6-0.6-0.5-0.4-0.1-0.1
Cd content in liver0.91.02.01.21.2-1.0-1.30.3-0.9-0.9-0.5-1.4-0.7
Co content in liver1.72.04.81.31.2-1.0-0.41.4-2.0-1.9-2.2-0.8-0.9
Cu content in liver0.10.20.50.10.1-0.0-0.0-0.0-0.6-0.6-0.7-0.4-0.5
Fe content in liver0.30.41.0-0.3-0.30.50.3-0.30.90.91.00.70.7
K content in liver1.41.42.7-0.8-0.60.80.8-0.21.51.51.41.51.7
Mg content in liver0.40.41.10.50.6-0.5-0.41.00.30.50.50.81.0
Mn content in liver2.02.35.0-1.9-2.01.91.7-2.21.21.01.00.20.3
Na content in liver0.30.30.6-0.7-0.80.70.7-0.60.40.30.40.30.4
Rb content in liver1.31.64.41.71.7-1.6-1.52.1-0.6-0.30.00.20.6
Se content in liver0.30.41.10.40.4-0.3-0.6-0.4-0.5-0.5-0.4-1.0-0.9
Sr content in liver1.91.63.7-1.7-1.71.81.7-1.90.30.1-0.3-0.1-0.5
Zn content in liver0.30.30.8-0.8-0.70.90.9-0.7-0.1-0.1-0.60.2-0.3
Bone: minimum diameter0.81.53.01.11.1-1.2-1.71.11.01.21.70.61.2
Time in familiar zone, hab. session 10.30.20.50.60.6-0.5-0.50.50.20.10.60.00.7
Time in novel zone, hab. session 10.20.20.70.30.3-0.4-0.20.8-0.3-0.2-0.60.5-0.2
Total zone transitions, hab. session 10.30.50.9-1.0-1.00.70.7-0.80.60.50.40.40.4
Total locomotion distance, hab. session 10.40.60.90.60.6-0.9-0.90.80.40.70.90.40.9
Locomotion velocity, hab. session 10.10.20.60.10.1-0.3-0.40.30.40.60.70.30.7
Time in familiar zone, hab. session 20.20.20.70.10.10.10.60.50.20.1-0.00.80.7
Time in novel zone, hab. session 20.10.10.2-0.3-0.30.1-0.2-0.40.10.10.1-0.2-0.4
Total zone transitions, hab. session 21.82.43.9-1.4-1.41.11.0-0.71.92.01.91.71.8
Total locomotion distance, hab. session 20.91.23.3-0.0-0.0-0.2-0.30.61.31.51.71.31.8
Locomotion velocity, hab. session 20.81.12.80.20.2-0.4-0.60.71.21.41.71.11.7
Novel to familiar place preference ratio0.91.03.4-1.2-1.21.20.8-1.80.70.50.3-0.4-0.7
Novelty place preference0.50.52.1-0.8-0.80.80.4-1.40.30.20.0-0.6-0.9
Time in novel zone, NPP test0.40.41.5-0.7-0.60.70.4-1.20.40.30.1-0.4-0.7
Total zone transitions, NPP test1.92.84.0-2.0-2.01.71.6-1.61.91.81.51.41.2
Total locomotion distance, NPP test0.50.71.6-0.3-0.3-0.1-0.10.31.11.21.31.11.3
Locomotion velocity, NPP test0.30.41.0-0.4-0.3-0.0-0.00.10.80.91.00.70.9
Intraocular pressure2.53.67.61.31.2-0.9-1.0-0.1-2.2-2.4-2.3-2.7-2.8
Delta distance traveled before/after self-admin0.50.51.60.40.4-0.60.00.9-1.0-1.0-1.3-0.1-0.5
Delta ambulatory time before/after self-admin0.30.31.20.20.2-0.40.20.7-0.8-0.7-1.10.2-0.2
Parametrial fat weight1.84.210.23.03.0-2.7-3.22.4-0.8-0.50.1-0.8-0.2
Pavlov. Cond. lever latency0.30.40.60.60.6-0.7-0.60.5-0.8-0.8-0.7-0.5-0.6
Pavlov. Cond. magazine entry latency0.40.51.0-0.6-0.60.70.4-0.81.00.90.90.40.6
Pavlov. Cond. change in total contacts0.20.20.9-0.3-0.30.50.0-0.90.1-0.00.0-0.7-0.7
Pavlov. Cond. index score0.20.30.8-0.6-0.60.80.6-0.90.30.10.0-0.3-0.1
Pavlov. Cond. latency score0.10.20.4-0.5-0.40.60.4-0.60.50.40.30.00.2
Pavlov. Cond. lever contacts0.30.30.6-0.3-0.30.50.3-0.20.80.80.80.60.7
Pavlov. Cond. magazine entry number0.40.51.50.70.7-0.8-0.61.20.10.30.50.70.7
Pavlov. Cond. intertrial magazine entries1.51.83.30.90.9-0.8-0.70.2-1.8-1.8-1.7-1.8-1.8
Pavlov. Cond. lever-magazine prob. diff.0.30.41.2-0.8-0.81.00.7-1.10.50.30.2-0.10.0
Pavlov. Cond. response bias0.20.30.9-0.6-0.60.70.5-0.90.1-0.0-0.1-0.4-0.3
Pavlov. Cond. lever latency0.40.61.70.90.9-0.8-0.51.3-0.8-0.6-0.60.10.1
Pavlov. Cond. magazine entry latency3.23.96.8-2.5-2.52.52.3-2.61.81.51.20.80.5
Pavlov. Cond. change in total contacts1.01.65.5-1.6-1.61.51.0-2.30.80.60.5-0.5-0.5
Pavlov. Cond. index score1.82.45.8-2.0-2.01.91.5-2.41.41.21.10.20.1
Pavlov. Cond. latency score1.62.14.9-1.8-1.81.71.3-2.21.41.21.20.20.1
Pavlov. Cond. lever contacts0.40.61.9-0.9-0.90.90.6-1.40.70.60.6-0.2-0.2
Pavlov. Cond. magazine entry number4.75.812.23.23.2-3.2-2.83.5-1.9-1.5-1.3-0.6-0.2
Pavlov. Cond. intertrial magazine entries0.61.01.71.31.3-1.1-1.21.0-0.9-0.9-0.7-0.8-0.3
Pavlov. Cond. lever-magazine prob. diff.2.12.96.7-2.1-2.22.11.7-2.61.51.21.10.20.0
Pavlov. Cond. response bias1.52.14.7-1.8-1.81.81.5-2.21.41.11.00.30.1
Time in closed arm before self-admin0.20.30.70.60.5-0.5-0.8-0.1-0.3-0.20.2-0.8-0.6
Time in closed arm after self-admin0.30.41.20.70.6-1.0-0.71.1-0.3-0.00.20.20.2
Time in open arm before self-admin0.60.72.80.40.4-0.40.21.7-0.10.1-0.41.41.2
Time in open arm after self-admin0.10.20.5-0.3-0.30.70.7-0.30.0-0.1-0.50.20.2
Bone: periosteal estimation0.61.24.3-0.10.0-0.1-0.7-0.11.51.62.10.71.4
Bone: periosteal perimeter0.50.82.4-0.5-0.40.2-0.2-0.51.31.31.50.61.0
Bone: post-yield work2.53.713.2-0.7-0.80.5-0.5-1.02.82.93.61.12.0
Progressive ratio test 1 active lever presses0.20.21.00.60.6-0.5-1.00.30.10.20.4-0.20.1
Progressive ratio test 1 breakpoint0.20.20.90.50.6-0.5-0.90.20.20.30.4-0.30.0
Progressive ratio test 1 inactive lever presses0.10.10.30.30.3-0.3-0.3-0.1-0.2-0.0-0.3-0.6-0.5
Progressive ratio test 2 active lever presses1.72.05.31.81.9-1.6-2.30.9-0.8-0.8-0.1-1.5-0.8
Progressive ratio test 2 breakpoint1.72.05.31.81.8-1.6-2.30.9-0.9-0.8-0.1-1.5-0.8
Progressive ratio test 2 inactive lever presses4.47.214.03.43.3-3.4-3.72.0-2.1-1.9-1.3-2.7-1.8
Incentive Sensitization - Responses0.10.20.70.20.20.1-0.5-0.30.50.40.8-0.30.2
Incentive Sensitization - Breakpoint0.10.20.60.50.4-0.1-0.8-0.10.30.20.7-0.40.1
Sum of active levers in priming session hrs 5-62.22.15.3-1.1-1.01.00.8-2.3-0.7-1.0-1.0-2.0-2.2
Progressive ratio1.42.24.3-1.2-1.31.40.7-1.12.01.92.11.31.4
Food seeking constrained by brief footshock0.10.10.4-0.1-0.10.20.30.20.30.30.20.70.2
Seeking ratio, punishment vs. effort1.31.93.31.51.6-1.5-0.71.8-1.7-1.5-1.7-0.4-0.7
Retroperitoneal fat weight5.623.846.46.86.7-6.6-6.56.3-3.1-2.4-1.2-2.0-0.8
Reaction time number correct0.10.20.5-0.6-0.60.60.7-0.60.0-0.0-0.2-0.0-0.2
Reaction time mean minus median1.43.68.0-2.3-2.52.21.8-2.81.71.41.70.20.5
Reaction time mean minus median AUC0.71.84.3-1.6-1.81.71.5-2.11.00.80.9-0.10.2
Reaction time num false alarms0.40.52.40.90.7-0.8-0.21.5-0.5-0.4-0.40.60.5
Reaction time num false alarms AUC0.10.20.80.20.1-0.00.50.9-0.1-0.0-0.10.80.5
Reaction time trials correct on left0.10.20.5-0.6-0.60.60.7-0.60.0-0.0-0.2-0.0-0.2
Reaction time trials on left0.10.30.7-0.7-0.80.70.8-0.70.10.0-0.2-0.0-0.2
Reaction time mean0.10.10.6-0.1-0.40.2-0.1-0.70.00.00.1-0.6-0.4
Reaction time mean AUC0.10.10.5-0.0-0.30.1-0.2-0.70.00.00.1-0.7-0.4
Median of all reaction times0.10.20.40.50.2-0.4-0.6-0.0-0.3-0.2-0.3-0.7-0.4
Reaction time omissions0.91.33.3-1.6-1.81.31.3-1.60.70.70.40.0-0.0
Reaction time false alarm rate0.30.41.80.80.7-0.6-0.21.4-0.1-0.00.10.70.7
Reaction time premature initiation rate2.12.95.2-1.9-2.02.02.3-0.81.41.30.92.11.5
Reaction time premature initiations2.03.58.2-2.4-2.52.52.9-1.51.21.00.51.71.0
Std. dev. reaction times0.50.92.9-1.2-1.41.10.9-1.70.50.40.7-0.5-0.2
Reaction time trials completed0.10.30.7-0.7-0.80.70.8-0.70.10.0-0.2-0.0-0.2
Reaction time trials AUC0.10.10.4-0.5-0.50.50.6-0.40.10.1-0.10.1-0.0
Run reversals in cocaine runway, females1.91.95.3-0.6-0.40.20.50.61.51.71.72.12.3
Run reversals in cocaine runway, males0.20.20.50.60.7-0.2-0.30.5-0.2-0.2-0.4-0.10.4
Latency to leave start box in cocaine runway0.20.31.10.10.4-0.4-0.70.40.40.61.10.30.4
Latency to leave start box in cocaine runway, F0.00.00.2-0.10.20.0-0.20.00.10.20.5-0.0-0.1
Latency to leave start box in cocaine runway, M0.50.41.40.10.0-0.3-0.40.30.70.81.20.70.9
Std. dev. time between licks in bursts0.20.20.90.20.2-0.30.31.0-0.10.1-0.20.90.6
Total sessions with >9 infusions0.60.71.90.20.2-0.2-0.60.31.01.11.40.71.3
Short access day 1 total inactive lever presses1.82.35.22.02.0-2.3-2.12.1-0.9-0.6-0.3-0.50.0
Short access day 10 total inactive lever presses0.30.71.20.80.8-1.0-0.61.1-1.0-0.9-0.7-0.3-0.6
Short access day 1 total infusions1.11.53.51.61.5-1.7-1.91.60.10.30.80.10.8
Short access day 10 total infusions1.21.63.80.80.8-0.8-1.50.81.31.42.00.81.6
Short access total infusions1.31.63.20.90.8-0.9-1.41.21.21.51.81.11.6
Short access day 1 locomotion0.91.12.61.51.5-1.5-1.61.2-0.30.00.3-0.40.1
Short access day 10 total locomotion0.40.72.21.21.2-1.2-1.50.7-0.10.20.3-0.4-0.1
Short access total locomotion0.91.13.31.41.5-1.5-1.81.1-0.10.20.5-0.40.1
One hour access (0.3 mA shock)4.24.810.03.03.0-2.9-3.22.3-1.4-1.2-0.7-1.5-1.0
Compulsive drug intake1.21.55.1-1.6-1.61.62.2-0.60.10.0-0.41.10.3
One hour access (shock baseline)4.06.114.13.33.3-3.2-3.82.0-1.6-1.3-0.7-2.2-1.4
Social response proportion0.50.61.2-1.0-1.01.00.8-1.10.60.50.30.10.2
Social responses0.20.30.9-0.6-0.60.90.9-0.70.40.1-0.1-0.00.1
Social time0.20.30.7-0.7-0.80.70.8-0.50.40.30.10.30.2
Soleus weight2.88.214.33.73.7-3.8-3.53.6-2.5-2.1-1.4-1.5-0.7
Bone: stiffness2.33.86.3-2.1-2.21.91.4-2.32.32.12.50.81.4
Tibialis anterior weight6.923.541.3-6.3-6.36.46.0-6.04.03.32.52.42.0
Time to tail flick, vehicle, before self-admin0.70.82.0-0.5-0.50.60.1-0.51.21.31.40.90.9
Time to tail flick, vehicle, after self-admin2.63.46.8-0.8-0.81.21.0-0.42.62.62.42.32.4
Time to tail flick, test, before self-admin1.61.73.71.51.5-1.5-1.51.90.40.61.00.71.4
Time to tail flick, test, after self-admin0.10.10.5-0.2-0.30.40.2-0.70.50.40.1-0.2-0.3
Delta time to tail flick, vehicle, before/after SA1.11.02.0-0.6-0.60.80.9-0.21.41.41.01.31.3
Delta time to tail flick, test, before/after SA2.42.55.1-1.5-1.51.51.5-2.2-0.7-1.0-1.6-1.4-2.2
Tibia length0.82.17.8-1.8-1.71.81.1-2.80.60.20.4-1.0-0.9
Ambulatory time before self-admin0.40.52.1-0.7-0.70.90.4-1.50.70.60.5-0.4-0.4
Ambulatory time after self-admin0.50.62.00.40.4-0.5-0.5-0.1-0.8-0.9-1.1-0.9-1.4
Bone: tissue strength0.10.10.20.10.0-0.1-0.2-0.1-0.2-0.30.0-0.5-0.4
Total heroin consumption3.54.07.8-2.7-2.72.62.7-2.81.41.10.60.6-0.1
Bone: trabecular number0.81.32.6-1.0-1.11.10.6-1.31.61.51.40.70.6
Bone: trabecular spacing0.40.61.30.90.8-0.8-0.31.1-1.0-1.0-0.6-0.20.0
Bone: trabecular thickness0.20.30.90.70.7-0.8-1.00.6-0.00.10.1-0.1-0.1
Bone: trabecular tissue density3.24.76.72.52.6-2.4-2.42.0-2.2-2.1-1.7-1.9-1.5
Water consumed over 24 hours0.70.92.3-1.3-1.31.21.5-1.2-0.1-0.3-0.7-0.0-0.4
Number of responses in last shaping day0.00.00.10.10.1-0.10.20.3-0.2-0.2-0.20.0-0.1