Hub : Genes

Rps6ka4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver mRNA stability Rps6ka4 0.06 0.04 4.7e-05 0.04 0.03 0.03 0.04 8.3e-05 3.2e-04 1.7e-04 8.2e-05
2 PL isoform ratio XM_039084019.1 0.03 0.02 1.8e-03 0.01 0.02 0.01 0.01 1.1e-02 1.9e-03 6.7e-02 1.5e-02
3 Adipose mRNA stability Rps6ka4 0.02 0.02 7.7e-03 0.01 0 -0 0 2.8e-02 9.5e-02 5.3e-01 1.5e-01
4 PL isoform ratio NM_001108517.2 0.03 0.02 2.0e-03 0.01 0.02 0 0.01 1.3e-02 2.4e-03 1.0e-01 1.7e-02
5 Adipose gene expression Rps6ka4 0.05 0.05 1.8e-03 0.01 0.01 0.01 0.01 2.2e-02 3.7e-02 4.4e-02 6.6e-02
6 NAcc intron excision ratio chr1_204032571_204032659 0.02 0.02 7.5e-03 0.01 0.01 -0 0.01 1.9e-02 2.5e-02 4.5e-01 4.2e-02
7 OFC gene expression Rps6ka4 0.14 0.09 4.4e-03 0.09 0.08 0.02 0.07 3.5e-03 5.9e-03 1.0e-01 9.8e-03
8 IL gene expression Rps6ka4 0.19 0.13 8.5e-03 0.05 0.08 0.08 0.06 3.0e-02 5.5e-03 5.0e-03 1.6e-02
9 NAcc gene expression Rps6ka4 0.08 0.05 6.6e-07 0.02 0.05 0.04 0.04 1.1e-03 1.3e-06 6.2e-06 9.1e-06
10 Brain gene expression Rps6ka4 0.08 0.05 6.4e-05 0.04 0.03 0.03 0.04 9.7e-05 3.5e-04 1.2e-03 3.1e-04
11 BLA gene expression Rps6ka4 0.43 0.16 1.0e-13 0.24 0.22 0.25 0.24 3.6e-13 3.0e-12 7.5e-14 2.4e-13
12 PL gene expression Rps6ka4 0.18 0.09 2.7e-12 0.12 0.11 0.12 0.11 2.7e-13 1.5e-12 1.3e-12 4.0e-12

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density0.91.43.3-0.7-0.50.70.5-0.8-0.9-0.6-1.81.4-1.7-1.5-1.8
Area under the delay curve0.30.31.10.10.4-0.0-0.4-0.10.2-0.2-0.20.8-0.7-0.9-1.0
BMI with tail4.915.930.6-2.7-1.82.71.7-3.2-3.0-2.5-5.55.0-5.4-5.3-5.5
BMI without tail2.65.410.9-1.7-1.01.51.0-2.3-1.9-1.7-2.83.2-2.9-3.3-2.9
Body weight4.317.927.7-4.1-3.34.13.2-4.4-4.4-3.8-5.34.7-4.3-4.7-4.1
Weight adjusted by age1.92.23.6-1.7-1.91.81.9-1.8-1.5-1.4-1.41.0-0.8-1.0-0.6
Bone surface4.47.813.5-2.8-2.92.82.9-2.9-2.9-1.9-3.72.6-2.6-2.5-2.8
Bone volume1.93.27.2-1.5-1.81.61.8-1.6-1.7-0.8-2.71.6-2.0-1.5-2.1
Breakpoint value in progressive ratio session2.42.65.0-1.9-2.21.92.2-1.9-1.8-1.5-1.61.0-0.4-0.8-0.4
Number of licking bursts0.20.20.4-0.5-0.70.70.7-0.6-0.6-0.4-0.30.20.1-0.2-0.2
Context. condit. distance diff. score1.21.42.91.71.7-1.6-1.71.51.21.20.8-0.50.00.3-0.1
Locomotion velocity, session 10.30.30.8-0.10.50.2-0.50.0-0.0-0.8-0.30.9-0.7-0.8-0.9
Locomotion distance, session 11.11.53.4-0.80.10.7-0.1-0.4-0.6-1.2-1.41.7-1.8-1.7-1.8
Locomotion velocity, session 22.53.04.0-1.9-1.51.91.5-1.7-1.7-2.0-1.81.9-1.3-1.9-1.4
Locomotion distance, session 20.81.12.3-1.0-0.20.90.1-0.7-0.6-1.4-1.01.5-1.2-1.4-1.4
Locomotion velocity, session 31.31.54.60.41.4-0.5-1.40.80.60.2-1.01.1-2.1-1.3-2.2
Locomotion distance, session 30.20.20.60.20.5-0.3-0.50.30.1-0.0-0.40.4-0.7-0.5-0.7
Stereotopy head waving bouts, day 31.31.64.10.81.7-0.8-1.71.01.10.5-0.60.9-2.0-1.0-1.7
Stereotopy head waving duration, day 30.70.81.80.91.3-1.0-1.31.11.10.90.2-0.0-0.8-0.0-0.6
Locomotion velocity, session 70.90.92.90.81.2-0.7-1.21.11.00.6-0.60.3-1.7-0.5-1.0
Locomotion distance, session 70.50.62.10.31.0-0.3-1.10.60.6-0.3-0.50.7-1.5-0.7-0.9
Stereotopy head waving bouts, day 70.10.10.60.30.1-0.3-0.10.40.20.8-0.3-0.2-0.3-0.0-0.5
Stereotopy head waving duration, day 71.01.21.9-1.1-1.31.21.4-1.1-1.4-0.6-1.30.8-0.6-0.9-0.9
Locomotion velocity, session 80.81.02.4-1.1-0.51.10.4-0.9-0.9-1.5-0.61.5-0.6-1.3-1.0
Locomotion distance, session 80.60.92.70.50.9-0.5-1.00.60.40.2-0.70.9-1.6-1.0-1.6
Degree of sensitization distance0.40.41.60.10.7-0.1-0.70.30.6-0.1-0.50.7-1.3-0.6-1.0
Degree of sensitization stereotypy0.50.51.2-0.7-1.10.81.1-0.6-0.9-0.1-0.90.3-0.2-0.3-0.6
Conditioned locomotion1.21.52.3-1.5-1.11.41.1-1.5-1.2-1.3-1.11.3-0.7-1.1-1.0
Cocaine response after cond. corrected1.11.33.71.31.9-1.4-1.91.11.30.80.7-0.1-0.2-0.1-0.4
Cocaine response after cond. not corrected0.80.92.71.21.6-1.3-1.60.90.90.70.30.1-0.5-0.3-0.5
Cocaine response before conditioning0.60.82.0-0.9-1.40.91.4-1.0-1.2-0.5-0.90.2-0.3-0.20.2
Saline control response3.24.26.2-2.4-2.12.42.1-2.5-2.4-2.4-1.81.9-1.2-1.7-0.7
Bone: connectivity density2.64.17.1-1.9-1.71.91.7-2.0-2.1-1.6-2.72.2-2.0-2.2-2.1
Bone: cortical apparent density0.30.41.4-0.6-0.70.50.7-0.5-0.5-0.60.4-0.30.80.51.2
Bone: cortical area0.60.91.6-1.0-1.20.91.3-1.1-1.0-0.5-1.10.6-0.7-0.5-0.6
Bone: cortical porosity0.10.10.2-0.3-0.20.30.2-0.1-0.1-0.2-0.50.1-0.4-0.3-0.1
Bone: cortical porosity0.50.50.8-0.9-0.70.80.7-0.7-0.8-0.8-0.90.4-0.5-0.6-0.2
Bone: cortical thickness1.82.95.0-2.2-2.22.02.1-2.2-2.2-2.1-0.90.90.1-0.70.6
Bone: cortical thickness0.40.41.6-0.7-0.30.80.3-0.7-0.7-1.3-0.30.8-0.3-0.50.1
Bone: cortical tissue density0.40.51.5-0.7-0.80.60.8-0.6-0.6-0.70.4-0.30.80.51.2
Condit. Reinf. active minus inactive responses0.10.10.3-0.4-0.30.40.3-0.4-0.3-0.6-0.30.2-0.3-0.3-0.1
Condit. Reinf. active-inactive response ratio0.10.10.5-0.2-0.30.10.3-0.2-0.1-0.20.4-0.40.60.40.7
Condit. Reinf. active responses0.10.10.3-0.1-0.10.10.1-0.0-0.0-0.1-0.50.1-0.5-0.4-0.3
Condit. Reinf. inactive responses0.30.31.20.30.4-0.2-0.40.50.30.3-0.80.3-1.1-0.6-0.9
Incentive salience index mean0.40.51.0-0.6-0.40.60.3-0.6-0.5-0.7-0.90.7-0.9-1.0-0.7
Condit. Reinf. lever presses0.50.71.6-0.6-0.50.60.5-0.7-0.6-0.5-1.30.9-1.2-1.1-1.1
Condit. Reinf. active minus inactive responses0.10.20.80.40.1-0.5-0.00.30.20.9-0.4-0.6-0.50.20.2
Condit. Reinf. active-inactive response ratio0.60.62.50.80.5-0.9-0.50.80.71.6-0.5-0.7-0.90.1-0.5
Condit. Reinf. active responses0.10.10.3-0.2-0.40.00.4-0.3-0.30.2-0.5-0.1-0.3-0.20.2
Condit. Reinf. inactive responses0.20.30.8-0.6-0.50.60.5-0.8-0.6-0.9-0.10.50.2-0.50.3
Condit. Reinf. lever presses1.72.44.2-1.7-2.01.62.0-1.7-1.8-0.8-1.91.0-1.1-0.9-0.8
Condit. Reinf. lever reinforcers received0.20.30.7-0.5-0.80.50.9-0.7-0.6-0.0-0.7-0.0-0.3-0.20.2
Conditioned reinforcement - actives0.40.41.20.5-0.1-0.40.10.70.60.80.3-0.90.41.10.4
Conditioned reinforcement - inactives5.46.010.02.81.7-2.8-1.72.52.63.22.6-2.82.22.51.5
Conditioned locomotion8.19.712.13.52.8-3.3-2.73.53.53.43.3-3.32.53.22.1
Patch foraging indifference point 0 sec0.00.10.20.20.1-0.2-0.10.4-0.10.4-0.2-0.40.20.10.3
Patch foraging indifference point AUC3.03.46.8-2.1-2.62.22.6-2.3-2.1-1.8-1.71.1-0.6-0.8-0.4
Delay disc. indifference point, 0s delay0.80.92.90.41.1-0.4-1.10.40.4-0.2-0.21.3-0.8-1.5-1.7
Delay disc. indifference point, 16s delay0.70.71.31.10.7-1.0-0.71.01.01.10.8-0.80.30.70.3
Delay disc. indifference point, 2s delay0.20.21.30.30.4-0.1-0.40.10.50.1-0.10.6-0.6-0.2-1.1
Delay disc. indifference point, 24s delay0.10.10.20.20.3-0.2-0.30.00.2-0.30.5-0.0-0.1-0.20.3
Delay disc. indifference point, 4s delay0.40.52.10.30.7-0.2-0.8-0.00.1-0.3-0.11.0-0.6-1.4-0.9
Delay disc. indifference point, 8s delay0.30.30.80.10.6-0.0-0.6-0.10.0-0.5-0.10.9-0.6-0.8-0.9
Indifference point function ln k6.49.018.33.64.3-3.7-4.33.63.32.92.7-1.60.81.10.7
Indifference point function log k6.49.018.33.64.3-3.7-4.33.63.32.92.7-1.60.81.10.7
Patch foraging total patch changes 0 sec0.00.10.30.10.1-0.1-0.10.3-0.20.1-0.0-0.40.40.00.5
Patch foraging total patch changes 12 sec4.05.28.9-2.5-2.72.72.7-2.5-3.0-2.4-2.51.7-0.9-1.7-0.9
Patch foraging total patch changes 18 sec0.70.91.8-0.8-1.31.01.3-1.2-1.2-0.5-1.20.3-0.7-0.5-0.0
Patch foraging total patch changes 24 sec2.32.85.2-1.9-2.12.02.1-2.0-2.3-1.6-1.61.0-0.4-1.1-0.3
Patch foraging total patch changes 6 sec0.71.11.4-1.1-0.91.10.8-1.0-1.1-1.1-1.21.2-0.9-1.1-1.0
Patch foraging time to switch 0 sec2.03.05.8-1.6-1.41.71.4-1.3-1.3-1.2-2.41.9-2.3-1.6-2.2
Patch foraging water rate 0 sec3.96.38.42.72.2-2.8-2.22.32.32.42.9-2.72.62.32.6
Patch foraging water rate 12 sec7.110.817.13.63.7-3.8-3.73.23.32.64.1-2.93.02.42.5
Patch foraging water rate 18 sec2.53.36.72.12.6-2.3-2.61.92.11.42.0-1.20.81.00.9
Patch foraging water rate 24 sec3.04.26.82.52.5-2.6-2.51.92.02.02.2-1.71.61.41.4
Patch foraging water rate 6 sec3.75.38.12.62.8-2.8-2.82.32.41.82.8-1.81.81.41.8
Seeking ratio, delayed vs. immediate footshock0.20.20.40.30.4-0.3-0.40.50.50.20.5-0.40.60.50.6
Distance traveled before self-admin0.60.61.4-0.9-1.20.91.2-0.7-1.0-0.4-1.10.3-0.3-0.3-0.3
Distance traveled after self-admin0.20.20.6-0.5-0.80.40.8-0.4-0.5-0.1-0.1-0.30.70.50.3
Extensor digitorum longus weight6.726.434.6-5.9-5.15.85.0-5.7-5.6-5.4-5.65.0-3.9-4.6-3.5
Bone: elastic displacement1.51.73.61.21.4-1.3-1.41.31.30.61.9-1.01.50.91.3
Bone: elastic work0.40.61.7-0.9-0.40.70.3-0.9-0.9-1.3-0.40.9-0.2-0.9-0.0
Bone: endosteal estimation1.02.25.91.31.6-1.3-1.61.21.51.4-0.90.6-2.2-0.8-2.4
Bone: endosteal perimeter1.12.25.51.51.4-1.4-1.31.41.51.9-0.90.2-2.0-0.4-2.3
Epididymis fat weight1.63.67.62.72.5-2.6-2.42.31.82.80.4-1.1-0.2-0.0-0.5
Delta time in closed arm before/after self-admin0.40.41.0-0.00.90.2-1.00.2-0.0-1.0-0.00.8-0.6-0.9-0.2
Delta time in open arm before/after self-admin0.50.51.6-0.2-1.20.21.3-0.6-0.40.4-0.0-0.70.90.70.7
Diff in mean of infusions in LGA sessions0.40.51.0-0.6-1.00.61.0-0.8-0.8-0.5-0.5-0.10.5-0.60.7
Delay discount exponential model param0.20.20.8-0.1-0.3-0.00.30.2-0.10.30.2-0.80.70.80.9
Extinction: sum of active levers before priming4.24.25.6-2.2-2.32.32.3-2.3-2.1-2.0-2.41.7-1.2-1.9-1.2
Active lever presses in extinction session 62.22.25.2-1.7-2.31.72.3-1.6-1.7-1.2-1.50.5-0.2-0.50.0
Bone: final force3.04.97.9-2.4-2.12.32.1-2.3-2.2-1.9-2.82.1-2.2-2.0-1.9
Bone: final moment2.64.36.8-2.2-2.02.12.0-2.2-2.1-1.8-2.62.0-2.0-1.9-1.8
Food consumed during 24 hour testing period0.40.41.5-0.2-0.80.30.8-0.4-0.20.20.5-0.71.20.80.9
Glucose1.62.44.21.82.1-2.0-2.01.91.92.00.4-0.4-0.80.1-1.0
Heart weight2.73.87.42.52.7-2.4-2.72.32.12.11.7-1.00.50.80.0
Delay discount hyperbolic model param0.30.31.0-0.0-0.3-0.10.30.2-0.10.30.3-0.90.70.91.0
Intermittent access intake day 1-15 change0.90.92.10.9-0.0-0.90.10.70.41.20.8-1.41.31.11.1
Intermittent access intake escalation0.70.61.60.80.1-0.8-0.00.70.31.10.6-1.31.00.90.9
Intermittent access intake escalation 20.50.51.50.4-0.4-0.40.50.3-0.10.80.5-1.21.10.91.0
Intermitt. access day 1 inactive lever presses2.02.13.31.71.4-1.7-1.41.71.81.81.4-1.40.71.30.6
Intermitt. access day 15 inactive lever presses2.32.54.91.81.3-1.9-1.22.01.82.21.3-1.91.01.30.7
Intermitt. access escalation Index2.42.14.31.82.0-1.8-2.11.61.71.41.5-0.60.50.90.3
Intermittent access day 1 total infusions4.04.68.22.72.9-2.7-2.82.72.72.80.7-0.8-0.80.4-1.2
Intermittent access day 15 total infusions5.76.413.13.32.7-3.3-2.63.22.83.61.5-2.20.61.50.2
Intermittent access terminal intake (last 3 days)3.53.89.92.72.1-2.7-2.02.52.03.10.5-1.4-0.20.7-0.6
Intermittent access total infusions3.33.78.02.52.2-2.5-2.22.52.22.80.5-1.2-0.50.7-0.6
Intermittent access day 1 locomotion3.13.37.02.22.6-2.2-2.62.12.02.00.4-0.0-1.1-0.3-1.4
Intermittent access day 15 total locomotion3.33.57.92.51.9-2.5-1.92.22.02.81.1-1.60.51.20.1
Intermittent access total locomotion4.14.610.12.92.6-2.9-2.52.72.43.20.6-1.2-0.50.6-0.9
Intermittent access standard deviation1.01.12.11.20.7-1.2-0.61.20.61.40.8-1.41.00.90.8
Left kidney weight0.41.02.61.41.0-1.3-1.01.21.11.60.4-0.90.30.80.1
Right kidney weight0.10.31.50.60.0-0.50.00.50.11.2-0.2-0.80.10.7-0.1
Cocaine induced anxiety0.10.10.2-0.1-0.40.10.5-0.3-0.00.1-0.4-0.0-0.4-0.1-0.3
Post-drug Anxiety1.01.12.4-1.2-1.51.21.5-1.1-1.2-0.9-1.10.6-0.5-0.7-0.5
Baseline Anxiety1.81.93.9-1.6-1.41.61.3-1.5-2.0-1.7-1.31.2-0.4-1.2-0.4
Tail length0.61.83.6-1.6-1.61.51.6-1.9-1.8-1.8-0.20.80.5-0.50.8
Length with tail1.66.09.8-3.0-2.73.02.6-3.0-3.1-2.9-2.12.0-0.9-1.7-0.9
Length without tail1.73.75.8-2.2-1.82.31.8-1.9-2.2-2.0-2.41.6-1.4-1.7-1.4
Times rat made contact with spout0.30.40.9-0.7-0.60.70.6-0.8-0.6-1.0-0.10.40.2-0.40.4
Lifetime Intake2.93.36.42.32.3-2.4-2.32.42.02.50.4-0.9-0.60.3-0.8
Liver weight, left0.20.41.40.20.5-0.2-0.50.30.50.2-0.70.5-1.2-0.6-0.9
Liver weight, right0.61.13.30.30.9-0.2-0.90.10.4-0.3-0.91.3-1.6-1.6-1.8
Locomotor activity1.62.64.51.92.1-1.9-2.11.61.41.21.9-1.11.30.81.2
Locomotor testing distance2.23.67.42.32.7-2.3-2.72.01.91.32.2-1.11.30.71.1
Locomotor testing rearing1.72.65.52.02.3-2.0-2.31.81.51.11.8-0.91.10.60.6
Locomotion in novel chamber3.34.19.12.51.9-2.6-1.82.52.13.01.4-2.10.71.70.6
Locomotion in novel chamber post-restriction2.53.14.52.11.8-2.1-1.82.12.02.01.5-1.60.71.70.8
Fecal boli incidents, locomotor time 10.20.20.9-0.2-0.90.31.0-0.4-0.30.5-0.6-0.10.10.2-0.1
Change in fecal boli incidents, locomotor task0.60.61.40.01.1-0.2-1.10.30.5-0.6-0.00.9-1.2-0.9-0.9
Time >=10cm from walls, locomotor time 10.80.82.20.70.6-0.7-0.50.70.61.4-1.00.0-1.5-0.8-1.2
Bouts of movement, locomotor time 12.02.14.8-1.2-1.91.12.0-1.1-1.4-0.80.5-1.02.21.12.0
Total resting periods, locomotor time 11.61.73.9-1.0-1.80.91.8-0.9-1.4-0.50.5-1.02.01.11.8
Rest time, locomotor task time 11.61.82.61.30.9-1.4-0.91.31.61.31.6-1.61.11.41.5
Distance moved, locomotor task time 10.80.92.7-0.3-0.10.40.1-0.5-0.9-0.4-1.31.1-1.3-1.6-1.4
Vertical activity count, locomotor time 10.90.92.01.31.4-1.2-1.41.20.81.10.6-0.40.20.0-0.2
Time >=10cm from walls, locomotor time 20.20.20.6-0.2-0.70.40.8-0.3-0.30.3-0.1-0.60.60.30.4
Bouts of movement, locomotor time 20.30.30.8-0.6-0.90.60.9-0.6-0.8-0.5-0.1-0.10.50.00.5
Total resting periods, locomotor time 20.10.10.4-0.4-0.60.30.6-0.4-0.5-0.2-0.0-0.10.40.00.3
Rest time, locomotor task time 21.92.23.91.81.9-1.8-1.92.01.91.71.0-1.0-0.10.60.2
Distance moved, locomotor task time 21.01.22.4-1.3-1.41.31.4-1.3-1.6-1.2-0.90.50.1-0.7-0.0
Vertical activity count, locomotor time 20.20.20.80.10.2-0.0-0.20.00.1-0.30.7-0.30.90.20.9
Light reinforcement 10.20.31.00.50.2-0.4-0.20.5-0.10.20.8-0.80.80.51.0
Light reinforcement 20.81.12.51.00.5-0.9-0.41.51.11.50.5-1.60.41.40.7
Bone: marrow area1.12.35.81.41.7-1.3-1.71.31.51.4-0.80.6-2.2-0.8-2.4
Bone: maximum diameter0.30.61.4-0.6-0.90.51.0-0.7-0.60.2-1.10.5-0.8-0.4-1.2
Bone: maximum force4.17.115.0-2.5-2.22.42.2-2.4-2.3-1.8-3.92.7-3.5-2.6-3.0
Bone: maximum moment3.56.112.8-2.3-2.02.22.0-2.2-2.1-1.6-3.62.5-3.2-2.5-2.8
Mean time between licks in bursts0.30.41.7-0.7-0.10.50.1-0.6-0.7-1.3-0.21.0-0.2-1.0-0.1
Mean num. licks in bursts0.20.20.40.40.5-0.5-0.50.40.50.10.6-0.30.30.30.7
Cd content in liver0.90.92.21.20.4-1.1-0.40.61.11.50.9-1.20.91.00.6
Co content in liver2.22.66.61.31.3-1.2-1.31.11.30.52.6-1.52.41.52.0
Cu content in liver0.20.20.5-0.6-0.70.60.7-0.7-0.4-0.50.10.10.5-0.10.1
Fe content in liver0.30.30.6-0.4-0.60.40.6-0.7-0.4-0.1-0.80.5-0.8-0.5-0.7
K content in liver2.52.55.0-1.2-0.81.20.8-1.4-1.1-1.2-2.02.0-2.2-2.0-2.0
Mg content in liver0.60.62.1-0.20.20.1-0.2-0.2-0.0-0.1-1.00.9-1.5-1.1-1.4
Mn content in liver1.92.24.3-1.8-2.11.62.1-1.7-1.7-1.0-1.80.7-0.9-0.9-0.5
Na content in liver1.01.01.7-1.3-1.21.21.2-1.0-1.0-1.0-1.20.7-0.8-0.6-0.6
Rb content in liver1.21.53.11.51.8-1.6-1.81.41.61.40.5-0.5-0.70.3-0.2
Se content in liver0.20.31.00.0-0.8-0.10.9-0.20.01.0-0.3-0.70.20.40.2
Sr content in liver2.72.45.1-1.9-2.32.02.2-1.8-2.0-1.7-0.80.50.6-0.20.4
Zn content in liver0.91.01.9-1.2-1.31.41.3-1.1-1.3-1.1-0.80.60.1-0.5-0.4
Bone: minimum diameter0.81.43.31.11.3-1.1-1.31.11.21.3-0.60.4-1.6-0.4-1.8
Time in familiar zone, hab. session 10.20.20.30.60.6-0.5-0.60.40.50.4-0.2-0.1-0.6-0.1-0.1
Time in novel zone, hab. session 10.30.30.80.30.7-0.4-0.80.50.40.00.90.10.60.1-0.1
Total zone transitions, hab. session 10.50.71.2-1.0-0.81.10.8-0.8-1.0-1.1-0.70.7-0.4-0.7-0.5
Total locomotion distance, hab. session 10.30.51.00.60.9-0.6-0.90.70.70.4-0.30.2-1.0-0.5-0.9
Locomotion velocity, hab. session 10.10.20.60.10.4-0.1-0.30.20.2-0.0-0.40.2-0.8-0.5-0.6
Time in familiar zone, hab. session 20.10.10.30.20.4-0.1-0.4-0.10.0-0.60.30.40.1-0.50.2
Time in novel zone, hab. session 20.10.10.2-0.3-0.30.20.3-0.1-0.10.1-0.20.0-0.00.1-0.5
Total zone transitions, hab. session 21.82.43.7-1.4-0.71.40.6-1.1-1.3-1.6-1.91.9-1.9-1.9-1.9
Total locomotion distance, hab. session 20.60.82.70.00.7-0.0-0.70.20.2-0.4-0.91.1-1.7-1.4-1.5
Locomotion velocity, hab. session 20.60.82.80.20.8-0.2-0.80.40.4-0.0-0.90.8-1.7-1.1-1.4
Novel to familiar place preference ratio1.21.33.1-1.2-1.71.21.8-1.3-1.4-0.4-1.30.4-0.3-0.3-0.6
Novelty place preference0.60.61.9-0.8-1.30.81.4-0.9-1.0-0.1-0.80.10.00.1-0.3
Time in novel zone, NPP test0.50.51.3-0.6-1.10.71.2-0.8-1.0-0.1-0.80.2-0.1-0.1-0.4
Total zone transitions, NPP test2.43.44.4-2.0-1.52.01.5-1.8-2.0-2.0-2.11.9-1.6-1.9-1.6
Total locomotion distance, NPP test0.40.61.8-0.30.40.2-0.40.0-0.1-0.5-0.91.0-1.3-1.2-1.3
Locomotion velocity, NPP test0.20.31.0-0.30.20.3-0.2-0.1-0.0-0.5-0.70.7-1.0-0.9-0.9
Intraocular pressure1.62.25.51.0-0.0-1.40.10.70.81.91.4-2.42.11.62.1
Delta distance traveled before/after self-admin0.10.10.40.20.5-0.3-0.50.10.20.00.6-0.00.60.30.1
Delta ambulatory time before/after self-admin0.10.10.50.10.5-0.2-0.50.00.2-0.20.70.20.60.0-0.0
Parametrial fat weight1.32.64.82.22.2-2.1-2.11.81.52.00.0-0.2-1.0-0.5-1.5
Pavlov. Cond. lever latency0.40.50.90.60.6-0.6-0.60.80.60.51.0-0.70.90.80.8
Pavlov. Cond. magazine entry latency0.40.51.0-0.5-0.60.50.6-0.7-0.7-0.3-1.00.7-0.8-0.8-0.8
Pavlov. Cond. change in total contacts0.10.10.5-0.2-0.70.30.7-0.3-0.20.2-0.3-0.20.00.4-0.1
Pavlov. Cond. index score0.20.20.6-0.5-0.80.50.8-0.7-0.5-0.2-0.40.1-0.0-0.10.1
Pavlov. Cond. latency score0.10.10.3-0.3-0.50.30.5-0.5-0.4-0.2-0.50.3-0.3-0.3-0.1
Pavlov. Cond. lever contacts0.10.10.4-0.1-0.10.10.1-0.3-0.1-0.2-0.50.4-0.6-0.5-0.5
Pavlov. Cond. magazine entry number0.40.51.40.71.2-0.6-1.20.80.80.20.30.2-0.5-0.3-0.5
Pavlov. Cond. intertrial magazine entries1.21.43.01.00.3-0.9-0.20.90.81.01.3-1.71.61.61.7
Pavlov. Cond. lever-magazine prob. diff.0.40.51.0-0.8-1.00.71.0-0.9-0.8-0.5-0.60.3-0.1-0.3-0.1
Pavlov. Cond. response bias0.10.20.5-0.4-0.70.40.7-0.6-0.5-0.1-0.3-0.10.10.10.2
Pavlov. Cond. lever latency0.60.81.60.81.0-0.7-1.00.91.00.11.3-0.61.00.70.7
Pavlov. Cond. magazine entry latency3.33.86.4-2.1-2.32.22.3-2.4-2.5-1.8-2.11.5-1.1-1.4-0.8
Pavlov. Cond. change in total contacts1.52.15.1-1.7-2.21.62.3-1.6-1.8-0.5-1.70.5-0.6-0.5-0.5
Pavlov. Cond. index score2.33.04.9-1.9-2.21.92.2-2.0-2.2-1.1-2.11.1-1.2-1.0-0.9
Pavlov. Cond. latency score2.02.54.1-1.6-1.91.61.9-1.8-2.0-0.9-2.01.1-1.3-1.1-1.1
Pavlov. Cond. lever contacts0.50.61.5-0.8-1.20.81.2-0.9-1.2-0.2-0.90.2-0.3-0.2-0.1
Pavlov. Cond. magazine entry number5.36.510.43.03.2-3.0-3.23.03.22.32.6-1.81.21.51.1
Pavlov. Cond. intertrial magazine entries0.81.11.81.31.1-1.3-1.11.11.31.21.0-0.90.50.60.6
Pavlov. Cond. lever-magazine prob. diff.2.73.55.7-2.1-2.42.12.4-2.2-2.4-1.3-2.21.3-1.2-1.1-0.9
Pavlov. Cond. response bias1.62.24.2-1.7-2.01.62.0-1.7-2.0-0.9-1.60.8-0.7-0.7-0.5
Time in closed arm before self-admin0.20.20.4-0.2-0.60.20.7-0.4-0.10.3-0.60.1-0.5-0.0-0.5
Time in closed arm after self-admin0.20.20.70.30.8-0.2-0.80.50.6-0.10.10.2-0.7-0.4-0.2
Time in open arm before self-admin0.70.82.70.81.6-0.8-1.60.90.5-0.11.10.10.5-0.00.5
Time in open arm after self-admin0.50.62.40.4-0.0-0.40.00.10.20.31.0-0.81.51.11.2
Bone: periosteal estimation0.40.93.70.10.1-0.1-0.10.00.20.6-1.40.8-1.9-0.8-1.9
Bone: periosteal perimeter0.40.62.3-0.3-0.40.40.4-0.4-0.30.1-1.30.7-1.3-0.7-1.5
Bone: post-yield work2.12.811.0-0.6-0.50.60.5-0.4-0.10.4-2.81.5-3.3-1.4-3.1
Progressive ratio test 1 active lever presses2.82.94.42.01.7-2.0-1.72.02.12.11.5-1.60.81.50.7
Progressive ratio test 1 breakpoint2.52.63.91.91.6-1.9-1.51.82.02.01.5-1.50.91.50.7
Progressive ratio test 1 inactive lever presses0.91.01.71.31.3-1.3-1.31.10.81.10.9-0.80.60.50.2
Progressive ratio test 2 active lever presses3.73.97.72.51.9-2.5-1.82.42.42.81.4-2.00.71.60.6
Progressive ratio test 2 breakpoint5.25.89.32.82.2-2.8-2.12.82.93.12.1-2.51.32.21.3
Progressive ratio test 2 inactive lever presses6.37.314.33.42.6-3.4-2.63.12.93.82.0-2.71.22.10.9
Incentive Sensitization - Responses0.40.41.40.80.4-0.9-0.40.70.61.20.1-0.80.10.50.1
Incentive Sensitization - Breakpoint0.70.71.91.00.5-1.1-0.50.90.91.40.3-1.00.20.70.3
Sum of active levers in priming session hrs 5-61.71.65.4-1.2-2.31.22.3-1.2-1.2-0.3-0.7-0.80.80.51.0
Progressive ratio2.93.45.7-1.8-1.51.81.5-1.6-1.8-1.5-2.42.0-1.9-2.2-2.1
Food seeking constrained by brief footshock0.10.20.6-0.20.10.2-0.1-0.3-0.1-0.7-0.00.8-0.2-0.8-0.4
Seeking ratio, punishment vs. effort2.32.85.61.81.8-1.7-1.81.51.71.02.4-1.31.51.61.7
Retroperitoneal fat weight3.812.421.24.64.4-4.6-4.44.34.04.52.1-2.40.31.70.1
Reaction time number correct0.30.40.8-0.7-0.70.60.7-0.7-0.9-0.6-0.50.2-0.0-0.80.3
Reaction time mean minus median2.93.86.6-2.3-2.52.22.6-2.4-2.3-1.2-2.21.2-1.5-1.0-0.9
Reaction time mean minus median AUC1.52.03.8-1.7-1.91.51.9-1.9-1.8-0.8-1.40.7-0.7-0.7-0.3
Reaction time num false alarms0.40.61.70.71.3-0.7-1.30.90.7-0.00.9-0.20.30.20.8
Reaction time num false alarms AUC0.10.10.5-0.00.60.0-0.60.1-0.0-0.70.30.30.0-0.30.5
Reaction time trials correct on left0.30.40.8-0.7-0.70.60.7-0.7-0.9-0.6-0.50.2-0.0-0.80.3
Reaction time trials on left0.30.50.9-0.8-0.80.70.8-0.8-1.0-0.7-0.60.3-0.0-0.80.3
Reaction time mean0.10.10.4-0.4-0.60.20.6-0.3-0.40.3-0.1-0.30.30.50.0
Reaction time mean AUC0.10.10.3-0.3-0.60.10.6-0.2-0.40.4-0.1-0.30.20.4-0.0
Median of all reaction times0.10.10.40.1-0.0-0.30.10.20.00.60.3-0.50.50.6-0.0
Reaction time omissions0.71.02.2-1.4-1.21.21.2-1.1-1.5-0.8-0.80.5-0.2-0.4-0.1
Reaction time false alarm rate0.30.41.40.61.1-0.6-1.20.80.7-0.10.70.0-0.00.20.3
Reaction time premature initiation rate1.82.56.2-2.0-1.11.91.0-1.7-1.1-2.5-1.21.9-1.0-1.6-0.8
Reaction time premature initiations2.73.88.6-2.6-1.82.51.8-2.3-1.7-2.9-1.41.9-0.7-1.8-0.3
Std. dev. reaction times0.60.92.3-1.3-1.51.11.5-1.1-1.1-0.4-0.80.1-0.40.20.1
Reaction time trials completed0.30.50.9-0.8-0.80.70.8-0.8-1.0-0.7-0.60.3-0.0-0.80.3
Reaction time trials AUC0.20.30.6-0.6-0.50.50.5-0.6-0.8-0.6-0.50.3-0.1-0.80.2
Run reversals in cocaine runway, females1.51.53.9-0.60.50.6-0.5-0.4-0.7-1.1-1.21.9-2.0-1.7-1.7
Run reversals in cocaine runway, males0.20.20.40.60.4-0.6-0.40.20.40.40.5-0.10.4-0.10.1
Latency to leave start box in cocaine runway0.10.10.40.20.4-0.1-0.40.40.70.2-0.00.3-0.50.2-0.6
Latency to leave start box in cocaine runway, F0.00.00.2-0.0-0.10.20.1-0.00.1-0.00.1-0.00.10.50.0
Latency to leave start box in cocaine runway, M0.30.30.90.10.6-0.3-0.60.50.80.2-0.20.5-0.9-0.2-0.9
Std. dev. time between licks in bursts0.20.30.90.30.9-0.5-1.00.50.3-0.30.70.20.3-0.20.2
Total sessions with >9 infusions1.71.94.61.62.1-1.6-2.11.61.51.40.3-0.0-0.7-0.2-1.0
Short access day 1 total inactive lever presses3.84.26.62.42.6-2.5-2.52.62.52.31.9-1.50.71.00.6
Short access day 10 total inactive lever presses3.53.86.02.12.4-2.2-2.52.22.41.72.3-1.41.21.31.1
Short access day 1 total infusions2.32.55.11.92.3-2.0-2.22.01.91.90.6-0.6-0.50.4-0.6
Short access day 10 total infusions1.82.03.61.41.9-1.4-1.91.71.41.5-0.50.2-1.7-0.6-1.6
Short access total infusions1.51.73.71.31.9-1.4-1.91.51.31.3-0.20.2-1.2-0.4-1.3
Short access day 1 locomotion1.81.94.41.72.1-1.7-2.11.61.21.50.2-0.1-0.7-0.3-1.0
Short access day 10 total locomotion1.21.32.71.51.6-1.5-1.61.41.21.40.4-0.3-0.30.1-0.6
Short access total locomotion1.21.33.11.41.8-1.3-1.81.31.21.10.20.1-0.7-0.1-0.9
One hour access (0.3 mA shock)7.99.215.03.83.2-3.7-3.13.73.63.92.5-2.81.32.31.0
Compulsive drug intake1.71.75.1-1.8-1.21.81.1-1.5-1.4-2.3-0.21.00.3-0.60.6
One hour access (shock baseline)6.97.916.93.62.5-3.6-2.43.43.14.12.0-2.91.22.30.7
Social response proportion0.70.81.4-1.1-1.21.21.2-1.0-0.7-0.8-0.80.7-0.1-0.3-0.4
Social responses0.30.30.7-0.7-0.80.60.8-0.8-0.7-0.6-0.30.30.3-0.30.3
Social time0.30.30.7-0.8-0.60.70.6-0.9-0.7-0.7-0.30.50.0-0.3-0.1
Soleus weight3.19.213.83.73.6-3.7-3.63.73.63.32.6-2.50.92.01.3
Bone: stiffness3.14.810.4-2.2-2.12.22.1-2.1-2.0-1.5-3.21.9-2.7-1.8-2.0
Tibialis anterior weight9.030.743.5-6.6-6.26.56.2-6.6-6.5-5.9-5.54.6-2.9-4.2-2.6
Time to tail flick, vehicle, before self-admin1.41.53.6-0.7-0.60.90.6-1.1-0.7-0.7-1.61.5-1.6-1.5-1.9
Time to tail flick, vehicle, after self-admin3.03.37.0-1.3-0.81.30.8-1.8-1.6-1.6-2.02.6-2.0-2.4-2.3
Time to tail flick, test, before self-admin1.21.12.30.81.5-0.9-1.50.80.40.5-0.50.7-1.4-1.3-1.4
Time to tail flick, test, after self-admin0.10.10.2-0.2-0.20.00.2-0.3-0.5-0.0-0.10.30.1-0.0-0.3
Delta time to tail flick, vehicle, before/after SA0.60.61.5-0.7-0.30.50.3-0.8-0.8-0.8-0.71.2-0.8-1.1-0.8
Delta time to tail flick, test, before/after SA1.81.63.3-1.2-1.81.21.8-1.2-0.9-0.90.4-0.51.61.51.4
Tibia length0.92.67.4-1.8-2.71.82.7-1.9-1.7-0.6-1.90.3-0.5-0.2-0.4
Ambulatory time before self-admin0.50.61.6-0.7-1.20.61.3-0.6-1.10.1-1.1-0.1-0.2-0.1-0.1
Ambulatory time after self-admin0.20.20.80.3-0.1-0.40.20.30.20.80.3-0.60.70.90.1
Bone: tissue strength0.10.10.2-0.1-0.3-0.10.30.1-0.00.3-0.3-0.4-0.10.30.3
Total heroin consumption4.65.48.0-2.8-2.82.72.8-2.8-2.7-2.6-2.31.7-0.9-1.6-0.8
Bone: trabecular number0.81.23.1-0.8-1.00.91.0-0.9-1.0-0.3-1.71.0-1.3-1.0-1.5
Bone: trabecular spacing0.40.51.30.50.8-0.5-0.80.70.7-0.01.0-0.60.50.51.1
Bone: trabecular thickness0.40.40.90.80.8-0.8-0.80.90.61.00.1-0.4-0.10.2-0.4
Bone: trabecular tissue density3.04.25.62.41.9-2.3-1.82.32.12.22.2-2.21.52.01.6
Water consumed over 24 hours0.70.81.4-1.1-1.21.01.2-1.1-0.9-1.10.10.10.80.10.9
Number of responses in last shaping day1.01.11.81.31.3-1.3-1.31.10.71.01.0-0.90.70.50.6