Carns1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Carns1	0.06	0.04	1.0e-07	0.08	0.07	0.07	0.05	1.1e-07	2.8e-07	6.8e-07	2.6e-05
2	pVTA	gene expression	Carns1	0.03	0.02	5.9e-03	0.02	0.01	0.01	0.01	1.4e-02	3.7e-02	4.7e-02	6.3e-02
3	NAcc	gene expression	Carns1	0.01	0.01	9.9e-03	0	0.01	0.01	0.01	5.4e-02	1.7e-02	7.8e-03	3.7e-02
4	BLA	intron excision ratio	chr1_210895896_210896285	0.06	0.05	9.5e-03	0.04	0.02	0.01	0.02	5.6e-03	1.8e-02	5.4e-02	1.9e-02
5	BLA	intron excision ratio	chr1_210895896_210896618	0.06	0.05	9.9e-03	0.04	0.02	0.01	0.02	2.3e-03	1.9e-02	7.1e-02	2.0e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	2.0	3.4	5.7	-1.3	-1.2	-1.6	2.4	-2.4
Area under the delay curve	0.8	1.0	1.3	-1.0	-0.8	-1.1	1.0	-1.0
BMI with tail	1.9	6.4	13.6	-0.8	-0.7	-1.9	3.7	-3.7
BMI without tail	0.7	2.0	4.8	0.1	0.3	-0.6	2.2	-2.2
Body weight	0.8	3.3	5.4	1.6	1.8	0.4	2.3	-2.3
Weight adjusted by age	0.4	0.6	1.4	1.1	1.2	0.7	0.2	-0.2
Bone surface	2.0	3.6	7.8	-0.3	-0.3	-1.4	2.8	-2.8
Bone volume	1.4	2.6	4.7	-0.9	-0.8	-1.5	2.2	-2.2
Breakpoint value in progressive ratio session	0.8	0.9	1.6	1.3	1.1	0.5	0.9	-0.9
Number of licking bursts	0.0	0.0	0.0	-0.0	0.0	-0.2	0.0	-0.0
Context. condit. distance diff. score	0.4	0.5	1.0	-1.0	-1.0	-0.7	0.0	-0.0
Locomotion velocity, session 1	0.0	0.0	0.0	-0.1	-0.0	-0.0	0.1	-0.1
Locomotion distance, session 1	1.2	1.5	2.6	-0.7	-0.6	-1.1	1.6	-1.6
Locomotion velocity, session 2	0.6	0.7	1.4	1.1	1.2	0.7	0.6	-0.6
Locomotion distance, session 2	0.4	0.6	1.4	0.2	0.2	-0.4	1.2	-1.2
Locomotion velocity, session 3	1.7	2.0	2.5	-1.3	-1.1	-1.4	1.6	-1.6
Locomotion distance, session 3	0.2	0.3	0.4	-0.4	-0.3	-0.4	0.6	-0.6
Stereotopy head waving bouts, day 3	1.5	1.8	2.5	-1.2	-1.4	-1.6	1.2	-1.2
Stereotopy head waving duration, day 3	1.0	1.2	2.1	-1.3	-1.4	-1.3	0.4	-0.4
Locomotion velocity, session 7	1.3	1.4	1.9	-0.9	-0.9	-1.2	1.4	-1.4
Locomotion distance, session 7	0.2	0.3	0.6	0.1	0.1	-0.2	0.8	-0.8
Stereotopy head waving bouts, day 7	1.5	1.7	2.2	-1.4	-1.4	-1.5	1.1	-1.1
Stereotopy head waving duration, day 7	1.0	1.2	2.0	-0.7	-0.7	-1.1	1.4	-1.4
Locomotion velocity, session 8	0.4	0.5	1.0	1.0	1.0	0.5	0.4	-0.4
Locomotion distance, session 8	0.3	0.4	0.6	-0.8	-0.8	-0.8	0.5	-0.5
Degree of sensitization distance	0.3	0.3	0.7	-0.0	-0.1	-0.5	0.8	-0.8
Degree of sensitization stereotypy	0.4	0.4	0.6	-0.5	-0.4	-0.7	0.8	-0.8
Conditioned locomotion	3.2	3.6	5.7	2.3	2.4	2.2	-1.0	1.0
Cocaine response after cond. corrected	0.1	0.1	0.2	-0.5	-0.5	-0.4	0.2	-0.2
Cocaine response after cond. not corrected	0.4	0.5	0.7	-0.8	-0.8	-0.8	0.5	-0.5
Cocaine response before conditioning	0.0	0.0	0.1	-0.2	-0.1	-0.2	0.2	-0.2
Saline control response	0.8	1.0	2.0	1.4	1.4	0.7	0.5	-0.5
Bone: connectivity density	2.1	3.3	7.3	-0.5	-0.4	-1.2	2.7	-2.7
Bone: cortical apparent density	0.4	0.6	1.0	0.9	1.0	0.9	-0.3	0.3
Bone: cortical area	0.8	1.2	1.7	1.2	1.3	1.1	-0.8	0.8
Bone: cortical porosity	0.0	0.0	0.1	-0.1	-0.1	-0.4	0.0	-0.0
Bone: cortical porosity	0.1	0.1	0.2	0.4	0.3	0.0	-0.0	0.0
Bone: cortical thickness	4.3	7.1	12.1	3.4	3.5	2.9	-1.4	1.4
Bone: cortical thickness	1.4	1.6	3.0	1.6	1.7	1.4	-0.5	0.5
Bone: cortical tissue density	0.5	0.7	1.3	1.1	1.1	1.0	-0.2	0.2
Condit. Reinf. active minus inactive responses	0.4	0.5	0.8	-0.3	-0.4	-0.6	0.9	-0.9
Condit. Reinf. active-inactive response ratio	0.3	0.4	0.4	-0.5	-0.5	-0.6	0.6	-0.6
Condit. Reinf. active responses	0.1	0.1	0.2	-0.2	-0.2	-0.3	0.4	-0.4
Condit. Reinf. inactive responses	0.0	0.0	0.1	-0.1	-0.1	0.1	-0.2	0.2
Incentive salience index mean	0.2	0.3	0.6	-0.1	-0.2	-0.4	0.8	-0.8
Condit. Reinf. lever presses	0.1	0.1	0.2	0.4	0.3	0.2	-0.2	0.2
Condit. Reinf. active minus inactive responses	1.7	2.1	2.6	-1.6	-1.6	-1.6	1.3	-1.3
Condit. Reinf. active-inactive response ratio	1.5	1.7	3.0	-1.7	-1.7	-1.5	0.5	-0.5
Condit. Reinf. active responses	1.8	2.5	2.9	-1.4	-1.4	-1.7	1.7	-1.7
Condit. Reinf. inactive responses	0.7	0.9	1.9	-0.1	-0.1	-0.6	1.4	-1.4
Condit. Reinf. lever presses	0.7	1.0	2.0	-0.3	-0.3	-0.8	1.4	-1.4
Condit. Reinf. lever reinforcers received	1.8	2.5	3.5	-1.2	-1.2	-1.6	1.9	-1.9
Conditioned reinforcement - actives	0.3	0.4	0.9	0.4	-0.0	0.4	-1.0	1.0
Conditioned reinforcement - inactives	1.2	1.8	4.1	-1.9	-2.0	-1.1	-0.3	0.3
Conditioned locomotion	2.2	2.9	4.4	-2.0	-2.1	-0.7	-1.7	1.7
Patch foraging indifference point 0 sec	0.2	0.3	0.8	-0.9	-0.8	-0.5	-0.2	0.2
Patch foraging indifference point AUC	0.9	1.3	2.7	1.6	1.5	1.2	-0.1	0.1
Delay disc. indifference point, 0s delay	2.0	2.2	2.6	-1.4	-1.5	-1.6	1.5	-1.5
Delay disc. indifference point, 16s delay	0.6	0.6	1.3	-1.2	-1.0	-0.8	-0.1	0.1
Delay disc. indifference point, 2s delay	0.8	0.8	1.3	-1.1	-1.0	-1.1	0.6	-0.6
Delay disc. indifference point, 24s delay	0.3	0.4	0.5	0.5	0.4	0.6	-0.7	0.7
Delay disc. indifference point, 4s delay	0.6	0.6	1.1	-0.4	-0.4	-0.8	1.0	-1.0
Delay disc. indifference point, 8s delay	0.2	0.3	0.4	-0.6	-0.4	-0.6	0.5	-0.5
Indifference point function ln k	1.1	2.0	3.4	-1.8	-1.8	-0.9	-1.1	1.1
Indifference point function log k	1.1	2.0	3.4	-1.8	-1.8	-0.9	-1.1	1.1
Patch foraging total patch changes 0 sec	0.1	0.1	0.3	-0.2	-0.1	0.2	-0.6	0.6
Patch foraging total patch changes 12 sec	0.9	1.2	2.5	1.6	1.4	0.8	0.7	-0.7
Patch foraging total patch changes 18 sec	0.1	0.1	0.2	0.3	0.2	0.0	0.4	-0.4
Patch foraging total patch changes 24 sec	0.4	0.8	1.6	1.2	1.2	1.0	-0.0	0.0
Patch foraging total patch changes 6 sec	0.4	0.5	1.3	0.2	0.2	-0.2	1.1	-1.1
Patch foraging time to switch 0 sec	1.0	2.1	3.9	-0.5	-0.4	-1.4	2.0	-2.0
Patch foraging water rate 0 sec	1.7	3.6	8.0	-0.1	-0.0	1.4	-2.8	2.8
Patch foraging water rate 12 sec	1.9	3.9	9.1	-0.4	-0.4	1.1	-3.0	3.0
Patch foraging water rate 18 sec	0.5	0.8	1.7	-0.5	-0.4	0.2	-1.3	1.3
Patch foraging water rate 24 sec	1.9	2.6	5.8	0.2	0.2	1.2	-2.4	2.4
Patch foraging water rate 6 sec	1.6	2.4	4.8	0.5	0.5	1.3	-2.2	2.2
Seeking ratio, delayed vs. immediate footshock	0.7	0.9	1.0	-0.8	-0.9	-0.9	1.0	-1.0
Distance traveled before self-admin	0.3	0.5	0.9	-0.4	-0.2	-1.0	0.8	-0.8
Distance traveled after self-admin	0.1	0.1	0.3	-0.2	0.1	-0.5	-0.1	0.1
Extensor digitorum longus weight	2.5	9.9	21.2	4.6	4.5	2.5	0.9	-0.9
Bone: elastic displacement	2.5	2.9	3.6	1.6	1.4	1.7	-1.9	1.9
Bone: elastic work	2.0	2.6	4.6	2.2	2.1	1.7	-0.8	0.8
Bone: endosteal estimation	1.5	3.3	5.3	-2.3	-2.3	-2.1	0.9	-0.9
Bone: endosteal perimeter	3.4	7.1	11.5	-3.3	-3.4	-3.1	1.3	-1.3
Epididymis fat weight	1.4	4.6	7.6	-2.8	-2.7	-1.4	-1.8	1.8
Delta time in closed arm before/after self-admin	0.9	0.9	2.0	1.4	1.1	0.9	0.0	-0.0
Delta time in open arm before/after self-admin	0.3	0.3	0.4	-0.5	-0.5	-0.5	0.6	-0.6
Diff in mean of infusions in LGA sessions	0.5	0.7	1.4	1.2	1.1	0.8	-0.2	0.2
Delay discount exponential model param	0.6	0.7	0.9	0.7	0.6	0.9	-0.9	0.9
Extinction: sum of active levers before priming	0.6	0.7	1.5	0.5	0.2	0.0	1.2	-1.2
Active lever presses in extinction session 6	0.6	0.6	1.6	1.1	1.3	0.4	0.3	-0.3
Bone: final force	0.3	0.5	0.7	0.8	0.8	0.2	0.7	-0.7
Bone: final moment	0.3	0.5	0.7	0.8	0.8	0.3	0.7	-0.7
Food consumed during 24 hour testing period	0.3	0.4	1.0	0.1	0.1	0.4	-1.0	1.0
Glucose	3.1	4.9	7.3	-2.7	-2.6	-2.5	1.4	-1.4
Heart weight	1.6	2.5	3.3	-1.8	-1.7	-1.8	1.2	-1.2
Delay discount hyperbolic model param	0.8	0.9	1.1	0.8	0.7	1.0	-1.0	1.0
Intermittent access intake day 1-15 change	0.8	1.6	2.5	-1.2	-1.3	-0.4	-1.6	1.6
Intermittent access intake escalation	0.7	1.5	2.6	-1.0	-1.0	-0.3	-1.6	1.6
Intermittent access intake escalation 2	0.9	1.0	1.4	-1.1	-1.1	-0.2	-1.2	1.2
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.1	-0.2	-0.4	-0.1	-0.1	0.1
Intermitt. access day 15 inactive lever presses	1.1	2.3	4.6	-2.1	-2.1	-1.6	0.0	-0.0
Intermitt. access escalation Index	0.8	1.1	2.5	-0.5	-0.3	-0.1	-1.6	1.6
Intermittent access day 1 total infusions	3.6	5.8	9.2	-3.0	-2.9	-2.5	1.7	-1.7
Intermittent access day 15 total infusions	2.8	4.1	8.7	-2.9	-2.9	-1.8	-0.4	0.4
Intermittent access terminal intake (last 3 days)	3.6	4.7	9.6	-3.1	-3.0	-2.2	0.3	-0.3
Intermittent access total infusions	3.3	3.9	7.0	-2.7	-2.6	-2.1	0.8	-0.8
Intermittent access day 1 locomotion	2.4	3.1	4.2	-2.0	-2.0	-2.0	1.2	-1.2
Intermittent access day 15 total locomotion	2.0	3.6	7.5	-2.7	-2.6	-1.9	-0.1	0.1
Intermittent access total locomotion	5.0	6.0	11.7	-3.4	-3.4	-2.7	0.2	-0.2
Intermittent access standard deviation	0.2	0.5	1.2	-1.1	-1.0	-0.5	-0.2	0.2
Left kidney weight	0.3	1.6	3.0	-1.7	-1.7	-1.0	-0.8	0.8
Right kidney weight	0.3	1.2	2.4	-0.9	-0.8	-0.1	-1.5	1.5
Cocaine induced anxiety	0.1	0.1	0.2	-0.4	-0.3	-0.4	0.3	-0.3
Post-drug Anxiety	0.1	0.1	0.2	0.2	0.3	0.1	0.4	-0.4
Baseline Anxiety	0.3	0.4	0.8	0.7	0.8	0.9	-0.0	0.0
Tail length	0.8	3.1	5.3	2.1	2.3	2.1	-0.9	0.9
Length with tail	1.3	5.8	11.7	3.2	3.4	2.6	-0.3	0.3
Length without tail	1.1	3.6	7.4	2.6	2.7	2.0	-0.0	0.0
Times rat made contact with spout	0.3	0.3	0.7	-0.0	-0.0	-0.5	0.8	-0.8
Lifetime Intake	2.2	2.7	4.8	-2.2	-2.2	-1.6	0.8	-0.8
Liver weight, left	0.4	0.7	1.6	0.2	0.2	0.6	-1.3	1.3
Liver weight, right	0.5	0.8	1.8	-0.6	-0.4	0.2	-1.3	1.3
Locomotor activity	0.4	0.6	1.4	-0.2	-0.2	0.3	-1.2	1.2
Locomotor testing distance	0.4	0.7	1.6	-0.3	-0.2	0.3	-1.3	1.3
Locomotor testing rearing	0.3	0.7	1.3	-1.1	-1.2	-0.9	0.2	-0.2
Locomotion in novel chamber	2.6	3.3	7.4	-2.7	-2.5	-1.3	-0.6	0.6
Locomotion in novel chamber post-restriction	1.0	1.7	3.5	-1.7	-1.9	-0.9	-0.7	0.7
Fecal boli incidents, locomotor time 1	0.1	0.1	0.1	-0.3	-0.2	-0.2	-0.3	0.3
Change in fecal boli incidents, locomotor task	0.0	0.0	0.1	0.1	-0.0	-0.1	0.3	-0.3
Time >=10cm from walls, locomotor time 1	3.7	4.0	6.3	-2.5	-2.4	-2.2	1.2	-1.2
Bouts of movement, locomotor time 1	1.5	1.7	3.0	1.7	1.6	1.4	-0.7	0.7
Total resting periods, locomotor time 1	1.2	1.3	1.9	1.4	1.4	1.2	-0.7	0.7
Rest time, locomotor task time 1	0.8	1.0	2.3	-0.4	-0.3	0.3	-1.5	1.5
Distance moved, locomotor task time 1	0.8	1.2	1.7	-0.8	-0.7	-1.2	1.3	-1.3
Vertical activity count, locomotor time 1	0.4	1.0	1.8	-1.3	-1.3	-1.2	0.4	-0.4
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.2	-0.1	-0.3	0.2	-0.4	0.4
Bouts of movement, locomotor time 2	0.1	0.2	0.5	0.7	0.5	0.4	0.2	-0.2
Total resting periods, locomotor time 2	0.0	0.1	0.1	0.4	0.2	0.1	0.2	-0.2
Rest time, locomotor task time 2	1.3	1.6	3.4	-1.8	-1.6	-1.4	0.1	-0.1
Distance moved, locomotor task time 2	1.0	1.2	2.0	1.4	1.4	1.2	-0.5	0.5
Vertical activity count, locomotor time 2	1.8	2.5	3.1	1.6	1.4	1.8	-1.5	1.5
Light reinforcement 1	0.1	0.3	0.8	-0.2	-0.3	0.1	-0.9	0.9
Light reinforcement 2	0.5	0.8	1.3	-0.8	-0.8	-0.1	-1.1	1.1
Bone: marrow area	1.6	3.4	5.6	-2.3	-2.4	-2.1	0.9	-0.9
Bone: maximum diameter	0.1	0.2	0.5	-0.1	-0.1	-0.0	-0.7	0.7
Bone: maximum force	1.1	2.0	4.4	-0.2	-0.2	-1.1	2.1	-2.1
Bone: maximum moment	1.0	1.8	3.9	-0.1	-0.1	-1.0	2.0	-2.0
Mean time between licks in bursts	0.1	0.3	0.6	0.8	0.7	0.4	0.3	-0.3
Mean num. licks in bursts	0.1	0.2	0.3	-0.3	-0.3	-0.4	0.5	-0.5
Cd content in liver	0.7	0.8	1.5	-1.2	-1.2	-0.8	-0.3	0.3
Co content in liver	1.3	1.5	2.2	0.9	0.8	1.3	-1.5	1.5
Cu content in liver	0.0	0.0	0.0	-0.1	-0.1	-0.1	0.1	-0.1
Fe content in liver	0.1	0.1	0.2	0.4	0.4	0.2	0.3	-0.3
K content in liver	0.4	0.3	0.8	0.1	-0.0	-0.4	0.9	-0.9
Mg content in liver	0.5	0.5	0.8	-0.9	-0.9	-0.9	0.4	-0.4
Mn content in liver	0.7	0.8	1.4	1.2	1.1	0.6	0.7	-0.7
Na content in liver	0.8	0.9	1.0	0.9	0.8	1.0	-1.0	1.0
Rb content in liver	1.5	1.8	3.0	-1.7	-1.6	-1.5	0.7	-0.7
Se content in liver	0.5	0.6	1.0	-0.8	-0.9	-1.0	0.6	-0.6
Sr content in liver	1.8	1.6	2.7	1.6	1.6	1.5	-0.5	0.5
Zn content in liver	0.4	0.5	0.8	0.9	0.9	0.8	-0.4	0.4
Bone: minimum diameter	2.1	3.8	5.9	-2.2	-2.3	-2.4	1.2	-1.2
Time in familiar zone, hab. session 1	0.6	0.6	0.8	-0.9	-0.9	-0.9	0.5	-0.5
Time in novel zone, hab. session 1	0.2	0.2	0.2	0.3	0.4	0.5	-0.5	0.5
Total zone transitions, hab. session 1	0.1	0.1	0.1	0.4	0.4	0.0	0.3	-0.3
Total locomotion distance, hab. session 1	0.3	0.4	0.7	-0.8	-0.8	-0.7	-0.1	0.1
Locomotion velocity, hab. session 1	0.1	0.1	0.1	-0.4	-0.4	-0.4	-0.1	0.1
Time in familiar zone, hab. session 2	0.9	0.9	1.5	1.1	1.2	1.1	-0.5	0.5
Time in novel zone, hab. session 2	1.2	1.2	1.5	-1.1	-1.1	-1.2	1.0	-1.0
Total zone transitions, hab. session 2	2.9	3.7	6.7	-0.9	-1.0	-1.8	2.6	-2.6
Total locomotion distance, hab. session 2	1.3	1.7	2.3	-1.1	-1.2	-1.5	1.4	-1.4
Locomotion velocity, hab. session 2	1.4	1.9	2.6	-1.3	-1.3	-1.6	1.3	-1.3
Novel to familiar place preference ratio	0.2	0.3	0.3	-0.4	-0.4	-0.6	0.6	-0.6
Novelty place preference	0.3	0.4	0.6	-0.7	-0.6	-0.7	0.5	-0.5
Time in novel zone, NPP test	0.3	0.4	0.6	-0.7	-0.6	-0.7	0.5	-0.5
Total zone transitions, NPP test	0.7	1.1	2.4	0.1	0.0	-0.7	1.6	-1.6
Total locomotion distance, NPP test	0.5	0.6	0.8	-0.6	-0.6	-0.9	0.9	-0.9
Locomotion velocity, NPP test	0.3	0.4	0.5	-0.4	-0.5	-0.7	0.7	-0.7
Intraocular pressure	0.8	1.1	2.2	0.4	0.4	0.9	-1.5	1.5
Delta distance traveled before/after self-admin	0.3	0.3	0.5	0.3	0.4	0.7	-0.7	0.7
Delta ambulatory time before/after self-admin	0.3	0.3	0.5	0.3	0.6	0.6	-0.7	0.7
Parametrial fat weight	1.4	3.3	6.6	-2.6	-2.5	-1.9	-0.1	0.1
Pavlov. Cond. lever latency	0.2	0.2	0.3	-0.6	-0.4	0.0	-0.6	0.6
Pavlov. Cond. magazine entry latency	0.7	0.9	1.4	-0.9	-0.9	-1.2	0.8	-0.8
Pavlov. Cond. change in total contacts	0.5	0.5	0.9	-0.7	-0.9	-0.9	0.4	-0.4
Pavlov. Cond. index score	0.0	0.0	0.0	0.1	-0.1	-0.2	-0.0	0.0
Pavlov. Cond. latency score	0.1	0.1	0.1	-0.0	-0.2	-0.4	0.3	-0.3
Pavlov. Cond. lever contacts	0.1	0.1	0.2	0.3	0.1	-0.2	0.4	-0.4
Pavlov. Cond. magazine entry number	0.0	0.1	0.1	-0.0	0.1	0.1	0.4	-0.4
Pavlov. Cond. intertrial magazine entries	0.4	0.4	0.7	0.4	0.4	0.7	-0.8	0.8
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.0	0.0	-0.1	-0.2	0.1	-0.1
Pavlov. Cond. response bias	0.1	0.1	0.2	0.2	0.1	0.1	-0.4	0.4
Pavlov. Cond. lever latency	0.1	0.1	0.1	-0.3	-0.3	-0.3	0.3	-0.3
Pavlov. Cond. magazine entry latency	1.2	1.5	3.4	0.5	0.4	-0.6	1.8	-1.8
Pavlov. Cond. change in total contacts	0.4	0.6	1.0	-0.4	-0.5	-0.8	1.0	-1.0
Pavlov. Cond. index score	0.3	0.4	0.9	0.2	0.1	-0.4	0.9	-0.9
Pavlov. Cond. latency score	0.2	0.3	0.6	0.2	0.1	-0.3	0.7	-0.7
Pavlov. Cond. lever contacts	0.0	0.0	0.0	0.2	0.2	0.2	-0.2	0.2
Pavlov. Cond. magazine entry number	1.4	1.8	4.0	-0.6	-0.5	0.5	-2.0	2.0
Pavlov. Cond. intertrial magazine entries	0.3	0.5	0.7	-0.6	-0.6	-0.1	-0.9	0.9
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	1.2	0.3	0.2	-0.4	1.1	-1.1
Pavlov. Cond. response bias	0.3	0.4	0.8	0.1	0.1	-0.4	0.9	-0.9
Time in closed arm before self-admin	1.1	1.4	2.7	-1.6	-1.3	-1.4	0.6	-0.6
Time in closed arm after self-admin	0.0	0.0	0.0	-0.2	-0.1	-0.0	-0.1	0.1
Time in open arm before self-admin	1.5	1.6	2.9	1.7	1.3	1.5	-0.8	0.8
Time in open arm after self-admin	0.2	0.3	0.6	0.7	0.6	0.4	0.4	-0.4
Bone: periosteal estimation	0.1	0.2	0.3	-0.6	-0.6	-0.5	-0.1	0.1
Bone: periosteal perimeter	0.5	0.9	1.5	-1.0	-1.0	-1.2	0.7	-0.7
Bone: post-yield work	8.4	12.3	14.5	-3.2	-3.2	-3.8	3.7	-3.7
Progressive ratio test 1 active lever presses	0.1	0.1	0.2	-0.2	-0.4	-0.1	0.3	-0.3
Progressive ratio test 1 breakpoint	0.0	0.1	0.1	-0.2	-0.4	-0.1	0.2	-0.2
Progressive ratio test 1 inactive lever presses	0.1	0.2	0.3	-0.3	-0.6	-0.4	0.4	-0.4
Progressive ratio test 2 active lever presses	1.2	1.4	3.0	-1.6	-1.7	-1.2	0.2	-0.2
Progressive ratio test 2 breakpoint	1.1	1.3	2.6	-1.5	-1.6	-1.1	0.1	-0.1
Progressive ratio test 2 inactive lever presses	3.2	5.2	11.6	-3.1	-3.4	-2.1	-0.4	0.4
Incentive Sensitization - Responses	0.7	1.0	1.1	-1.0	-0.8	-1.1	1.0	-1.0
Incentive Sensitization - Breakpoint	0.8	1.0	1.3	-1.1	-0.9	-1.1	0.9	-0.9
Sum of active levers in priming session hrs 5-6	3.6	3.3	4.4	1.6	1.6	1.5	-2.1	2.1
Progressive ratio	2.4	3.7	6.6	-1.3	-1.2	-1.6	2.6	-2.6
Food seeking constrained by brief footshock	0.1	0.1	0.2	-0.1	-0.0	-0.3	0.4	-0.4
Seeking ratio, punishment vs. effort	1.4	2.0	4.1	0.7	0.7	1.0	-2.0	2.0
Retroperitoneal fat weight	2.6	11.2	20.2	-4.5	-4.4	-2.4	-2.3	2.3
Reaction time number correct	0.5	1.0	1.6	1.2	1.3	1.2	-0.6	0.6
Reaction time mean minus median	0.3	0.8	1.9	0.2	0.5	-0.0	1.4	-1.4
Reaction time mean minus median AUC	0.3	0.7	1.1	0.8	1.0	0.6	0.8	-0.8
Reaction time num false alarms	1.0	1.4	2.0	1.0	1.1	1.4	-1.1	1.1
Reaction time num false alarms AUC	0.9	1.4	2.2	1.3	1.4	1.5	-0.7	0.7
Reaction time trials correct on left	0.5	1.0	1.6	1.2	1.3	1.2	-0.6	0.6
Reaction time trials on left	0.6	1.2	1.9	1.3	1.4	1.3	-0.6	0.6
Reaction time mean	0.3	0.4	0.7	-0.9	-0.6	-0.7	0.5	-0.5
Reaction time mean AUC	0.4	0.6	1.0	-1.0	-0.7	-0.8	0.6	-0.6
Median of all reaction times	0.6	0.8	1.4	-1.2	-1.0	-1.0	0.5	-0.5
Reaction time omissions	0.6	0.9	1.6	1.0	1.3	0.7	0.8	-0.8
Reaction time false alarm rate	0.3	0.5	0.8	0.6	0.7	0.9	-0.6	0.6
Reaction time premature initiation rate	1.0	1.4	2.1	1.4	1.4	0.8	1.0	-1.0
Reaction time premature initiations	1.5	2.7	5.3	2.2	2.3	1.6	0.5	-0.5
Std. dev. reaction times	0.2	0.3	0.8	-0.3	0.1	-0.2	0.9	-0.9
Reaction time trials completed	0.6	1.2	1.9	1.3	1.4	1.3	-0.6	0.6
Reaction time trials AUC	0.5	0.9	1.5	1.2	1.2	1.1	-0.5	0.5
Run reversals in cocaine runway, females	0.8	0.8	1.8	-0.4	-0.2	-0.6	1.3	-1.3
Run reversals in cocaine runway, males	1.3	1.3	1.9	0.9	1.1	1.4	-1.2	1.2
Latency to leave start box in cocaine runway	1.3	1.4	2.2	-1.2	-1.2	-1.5	1.0	-1.0
Latency to leave start box in cocaine runway, F	0.8	0.9	1.3	-0.9	-0.7	-1.1	0.9	-0.9
Latency to leave start box in cocaine runway, M	0.1	0.1	0.3	-0.2	-0.4	-0.5	0.3	-0.3
Std. dev. time between licks in bursts	1.5	2.1	3.0	1.7	1.7	1.6	-0.9	0.9
Total sessions with >9 infusions	0.4	0.5	1.0	-0.4	-0.5	-0.5	1.0	-1.0
Short access day 1 total inactive lever presses	0.7	0.9	1.9	-1.3	-1.4	-0.7	-0.5	0.5
Short access day 10 total inactive lever presses	0.0	0.1	0.1	-0.2	-0.4	-0.3	0.0	-0.0
Short access day 1 total infusions	0.9	1.2	2.6	-1.6	-1.6	-1.0	0.2	-0.2
Short access day 10 total infusions	2.8	3.5	4.1	-1.9	-1.7	-2.0	1.9	-1.9
Short access total infusions	1.2	1.5	1.6	-1.2	-1.3	-1.1	1.3	-1.3
Short access day 1 locomotion	0.8	1.0	1.8	-1.2	-1.4	-1.1	0.4	-0.4
Short access day 10 total locomotion	0.8	1.5	2.4	-1.6	-1.2	-1.5	0.9	-0.9
Short access total locomotion	1.3	1.5	2.4	-1.5	-1.5	-1.4	0.7	-0.7
One hour access (0.3 mA shock)	2.5	2.9	6.5	-2.4	-2.6	-1.4	-0.2	0.2
Compulsive drug intake	1.9	2.3	4.6	2.1	1.8	1.9	-0.4	0.4
One hour access (shock baseline)	2.7	4.1	8.5	-2.9	-2.8	-2.0	-0.4	0.4
Social response proportion	0.4	0.4	0.9	-0.1	0.0	-0.3	1.0	-1.0
Social responses	0.3	0.4	0.8	0.9	0.9	0.7	0.3	-0.3
Social time	0.3	0.4	0.6	0.7	0.7	0.3	0.8	-0.8
Soleus weight	1.2	3.6	6.9	-1.4	-1.5	-0.1	-2.6	2.6
Bone: stiffness	1.1	1.9	3.3	-0.5	-0.6	-1.5	1.8	-1.8
Tibialis anterior weight	5.0	16.9	34.2	5.8	5.8	4.0	-0.8	0.8
Time to tail flick, vehicle, before self-admin	0.8	0.8	1.1	-0.9	-0.5	-1.0	1.0	-1.0
Time to tail flick, vehicle, after self-admin	1.4	1.9	4.5	-0.0	-0.2	-0.6	2.1	-2.1
Time to tail flick, test, before self-admin	2.5	2.6	3.3	-1.6	-1.8	-1.8	1.4	-1.4
Time to tail flick, test, after self-admin	0.2	0.2	0.3	-0.2	0.5	0.2	-0.6	0.6
Delta time to tail flick, vehicle, before/after SA	0.8	0.8	1.8	0.6	0.1	-0.2	1.3	-1.3
Delta time to tail flick, test, before/after SA	5.1	5.3	6.7	1.9	2.6	2.5	-2.2	2.2
Tibia length	0.8	2.3	2.5	1.4	1.5	1.6	-1.5	1.5
Ambulatory time before self-admin	0.5	0.7	1.5	-0.5	-0.6	-1.2	0.9	-0.9
Ambulatory time after self-admin	1.1	1.3	2.3	-1.5	-1.3	-1.5	0.4	-0.4
Bone: tissue strength	0.3	0.3	0.5	-0.5	-0.6	-0.7	0.3	-0.3
Total heroin consumption	1.3	1.6	2.8	1.6	1.7	1.0	0.8	-0.8
Bone: trabecular number	1.9	3.1	5.5	-1.1	-1.0	-1.5	2.3	-2.3
Bone: trabecular spacing	0.3	0.4	0.8	0.4	0.3	0.4	-0.9	0.9
Bone: trabecular thickness	1.3	1.6	2.0	-1.4	-1.4	-1.2	1.1	-1.1
Bone: trabecular tissue density	2.1	3.1	6.8	-1.0	-1.0	0.1	-2.6	2.6
Water consumed over 24 hours	0.2	0.2	0.4	0.3	0.3	-0.2	0.6	-0.6
Number of responses in last shaping day	0.1	0.1	0.1	0.4	0.1	0.2	0.3	-0.3