Hub : Genes

Stmn2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 LHb gene expression Stmn2 0.34 0.16 5.1e-04 0.06 0.05 0.09 0.06 1.5e-02 2.8e-02 4.7e-03 1.8e-02
2 NAcc gene expression Stmn2 0.02 0.02 1.6e-03 0.02 0.01 0.01 0.01 1.1e-03 4.3e-03 2.6e-03 3.7e-03
3 IC gene expression Stmn2 0.24 0.12 1.7e-05 0.11 0.1 0.09 0.1 2.9e-05 3.9e-05 1.5e-04 4.7e-05
4 pVTA mRNA stability Stmn2 0.07 0.06 1.1e-04 0.05 0.05 0.04 0.04 5.4e-05 8.6e-05 4.3e-04 1.8e-04
5 Brain gene expression Stmn2 0.08 0.05 9.7e-05 0.01 0.03 0.03 0.02 1.6e-02 1.7e-03 1.5e-03 3.0e-03
6 Adipose gene expression Stmn2 0.06 0.04 8.4e-05 0.03 0.03 0.03 0.03 1.1e-04 3.4e-04 7.2e-04 4.0e-04
7 NAcc mRNA stability Stmn2 0.16 0.12 8.9e-07 0.05 0.05 0.05 0.05 2.1e-08 1.2e-07 1.1e-07 2.9e-08
8 Brain mRNA stability Stmn2 0.04 0.04 9.3e-03 0.01 0 0.01 0 4.9e-02 1.0e-01 8.2e-02 1.4e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.81.42.11.3-1.21.5-1.11.40.8-1.1-0.5
Area under the delay curve1.01.12.6-1.00.8-1.61.0-1.4-0.80.80.6
BMI with tail1.55.213.1-3.63.4-2.42.7-0.80.9-1.4-0.6
BMI without tail2.47.317.1-4.13.9-3.13.3-1.20.8-1.6-0.6
Body weight1.25.111.0-3.33.1-1.83.1-0.51.2-1.9-1.5
Weight adjusted by age0.10.10.3-0.00.40.30.5-0.1-0.2-0.60.2
Bone surface0.91.63.40.8-0.61.5-0.41.81.4-1.7-1.2
Bone volume1.01.93.71.1-1.01.6-1.01.91.3-1.6-1.0
Breakpoint value in progressive ratio session0.30.30.6-0.80.6-0.30.40.30.8-0.6-0.6
Number of licking bursts0.10.20.5-0.50.3-0.70.4-0.4-0.30.40.1
Context. condit. distance diff. score0.20.30.6-0.00.2-0.50.3-0.7-0.80.40.6
Locomotion velocity, session 10.00.00.2-0.30.2-0.4-0.10.00.1-0.10.2
Locomotion distance, session 10.70.91.9-0.60.70.10.81.01.4-1.2-1.2
Locomotion velocity, session 21.51.73.0-1.71.5-1.01.50.51.4-1.1-1.3
Locomotion distance, session 22.02.86.6-0.70.80.51.02.02.6-2.2-2.1
Locomotion velocity, session 30.50.61.10.7-0.80.0-1.1-0.6-0.90.80.9
Locomotion distance, session 30.40.50.90.4-0.51.0-0.31.00.6-0.7-0.8
Stereotopy head waving bouts, day 30.20.30.80.8-0.80.3-0.90.2-0.1-0.10.2
Stereotopy head waving duration, day 30.40.51.1-0.40.4-1.10.3-0.9-0.70.60.7
Locomotion velocity, session 79.410.217.23.0-3.24.0-3.04.22.6-2.4-2.8
Locomotion distance, session 73.44.38.82.5-2.53.0-2.22.31.0-0.9-1.2
Stereotopy head waving bouts, day 70.30.30.8-0.60.6-0.70.9-0.10.1-0.5-0.5
Stereotopy head waving duration, day 70.60.81.8-1.11.0-1.31.2-0.8-0.20.0-0.1
Locomotion velocity, session 81.51.73.9-1.91.7-1.32.00.00.9-0.7-0.7
Locomotion distance, session 80.50.71.6-0.80.9-0.31.30.61.0-0.9-0.8
Degree of sensitization distance0.60.61.21.0-1.11.0-1.00.80.3-0.1-0.2
Degree of sensitization stereotypy1.51.63.7-1.71.6-1.71.9-0.9-0.1-0.2-0.2
Conditioned locomotion0.30.41.10.2-0.20.6-0.51.10.7-0.5-0.6
Cocaine response after cond. corrected0.30.40.91.0-0.90.8-0.90.1-0.20.1-0.1
Cocaine response after cond. not corrected1.51.84.32.1-2.01.6-1.70.3-0.50.30.2
Cocaine response before conditioning0.80.92.21.5-1.51.3-1.10.5-0.20.00.0
Saline control response0.20.30.8-0.0-0.20.5-0.30.90.6-0.9-0.6
Bone: connectivity density0.91.53.01.4-1.21.7-0.91.40.8-1.1-0.6
Bone: cortical apparent density0.00.10.2-0.40.4-0.10.3-0.2-0.0-0.00.2
Bone: cortical area1.31.94.5-2.02.1-1.61.7-0.10.7-0.9-0.5
Bone: cortical porosity0.10.10.20.10.20.2-0.30.20.3-0.4-0.1
Bone: cortical porosity0.10.10.30.20.10.2-0.50.40.3-0.50.0
Bone: cortical thickness0.71.22.5-1.51.6-1.11.4-0.10.6-0.8-0.8
Bone: cortical thickness2.83.36.8-2.52.5-2.62.3-1.10.00.10.6
Bone: cortical tissue density0.00.10.1-0.40.4-0.10.3-0.3-0.00.00.2
Condit. Reinf. active minus inactive responses2.93.26.5-0.90.71.00.52.32.5-2.5-2.4
Condit. Reinf. active-inactive response ratio4.54.99.4-1.10.91.30.52.83.1-3.0-2.9
Condit. Reinf. active responses2.63.36.4-0.80.61.00.52.32.5-2.5-2.5
Condit. Reinf. inactive responses0.10.20.5-0.40.5-0.60.7-0.20.1-0.2-0.2
Incentive salience index mean3.23.97.4-1.41.20.70.92.32.7-2.7-2.6
Condit. Reinf. lever presses2.23.05.3-1.81.8-0.21.51.42.0-2.1-2.3
Condit. Reinf. active minus inactive responses1.62.14.50.9-0.81.9-0.72.11.7-1.4-1.5
Condit. Reinf. active-inactive response ratio1.51.73.4-0.1-0.01.10.31.81.8-1.5-1.8
Condit. Reinf. active responses2.63.67.41.8-1.62.7-1.42.61.7-1.5-1.5
Condit. Reinf. inactive responses0.70.92.01.0-1.01.4-1.11.10.4-0.5-0.4
Condit. Reinf. lever presses0.60.91.91.1-0.91.4-0.41.30.6-0.5-0.8
Condit. Reinf. lever reinforcers received2.33.36.61.8-1.62.6-1.32.41.6-1.3-1.4
Conditioned reinforcement - actives0.71.22.61.5-1.41.6-1.40.7-0.1-0.20.0
Conditioned reinforcement - inactives0.40.61.90.6-0.41.4-0.41.00.8-0.3-0.7
Conditioned locomotion0.60.81.61.2-1.11.3-0.81.00.20.1-0.2
Patch foraging indifference point 0 sec0.50.91.81.3-1.40.7-0.9-0.1-0.71.10.5
Patch foraging indifference point AUC0.30.51.10.9-0.91.1-0.70.70.2-0.1-0.4
Delay disc. indifference point, 0s delay0.30.31.1-0.20.1-0.50.3-1.1-0.70.70.5
Delay disc. indifference point, 16s delay0.30.30.8-0.90.8-0.90.7-0.2-0.00.1-0.1
Delay disc. indifference point, 2s delay0.80.91.4-1.00.9-0.21.20.31.0-1.2-1.1
Delay disc. indifference point, 24s delay0.10.20.6-0.50.4-0.80.2-0.2-0.20.40.2
Delay disc. indifference point, 4s delay2.22.34.1-1.81.6-2.01.8-2.0-0.80.40.6
Delay disc. indifference point, 8s delay0.91.12.50.1-0.1-1.10.1-1.6-1.41.31.2
Indifference point function ln k0.81.33.1-1.41.3-1.80.7-1.3-0.60.80.9
Indifference point function log k0.81.33.1-1.41.3-1.80.7-1.3-0.60.80.9
Patch foraging total patch changes 0 sec0.50.91.71.2-1.30.4-0.8-0.4-1.01.30.7
Patch foraging total patch changes 12 sec0.70.91.71.3-1.30.5-0.7-0.4-1.01.20.4
Patch foraging total patch changes 18 sec0.10.20.50.5-0.70.1-0.20.1-0.30.60.1
Patch foraging total patch changes 24 sec0.20.30.80.9-0.80.4-0.20.0-0.40.70.3
Patch foraging total patch changes 6 sec0.30.41.00.8-1.00.3-0.4-0.3-0.70.70.3
Patch foraging time to switch 0 sec1.32.64.2-1.61.5-0.11.51.42.0-2.0-1.9
Patch foraging water rate 0 sec0.61.32.81.0-1.0-0.3-0.7-1.2-1.61.21.7
Patch foraging water rate 12 sec0.10.30.50.7-0.60.0-0.7-0.3-0.60.40.6
Patch foraging water rate 18 sec0.10.10.40.3-0.40.2-0.6-0.0-0.3-0.20.2
Patch foraging water rate 24 sec0.71.02.00.0-0.2-1.0-0.2-1.3-1.41.01.4
Patch foraging water rate 6 sec0.71.11.80.9-1.0-0.1-1.2-0.8-1.31.21.2
Seeking ratio, delayed vs. immediate footshock2.63.16.32.3-2.52.2-2.51.30.10.8-0.1
Distance traveled before self-admin2.33.16.6-2.52.3-2.42.6-0.70.3-0.2-0.2
Distance traveled after self-admin0.91.12.7-1.61.6-1.31.4-0.1-0.00.0-0.1
Extensor digitorum longus weight6.123.851.0-7.16.7-5.47.0-0.72.3-2.5-2.0
Bone: elastic displacement0.40.50.90.1-0.20.8-0.50.90.8-0.7-1.0
Bone: elastic work0.30.41.0-0.20.20.20.70.80.8-0.7-1.0
Bone: endosteal estimation0.71.63.3-1.01.1-0.21.01.51.8-1.8-0.9
Bone: endosteal perimeter0.20.51.0-0.40.5-0.20.70.91.0-1.0-0.4
Epididymis fat weight0.00.10.3-0.60.4-0.30.4-0.20.20.0-0.0
Delta time in closed arm before/after self-admin0.70.72.1-1.10.7-1.51.0-0.8-0.00.40.1
Delta time in open arm before/after self-admin0.20.20.60.3-0.20.8-0.50.80.5-0.3-0.2
Diff in mean of infusions in LGA sessions1.01.22.2-1.51.4-0.81.20.41.0-1.1-0.8
Delay discount exponential model param0.91.02.30.8-0.71.5-0.91.40.8-0.8-0.6
Extinction: sum of active levers before priming0.40.40.70.8-0.80.7-0.80.50.2-0.7-0.0
Active lever presses in extinction session 60.10.10.6-0.30.3-0.4-0.10.0-0.20.80.1
Bone: final force1.11.83.4-1.71.7-0.91.80.61.3-1.3-1.1
Bone: final moment1.01.63.0-1.61.6-0.91.70.51.1-1.2-1.0
Food consumed during 24 hour testing period0.81.12.4-1.31.2-1.61.1-1.0-0.60.20.8
Glucose0.50.92.0-1.11.0-1.41.0-0.8-0.60.50.6
Heart weight0.20.30.60.1-0.1-0.5-0.3-0.5-0.70.60.8
Delay discount hyperbolic model param0.91.02.21.1-0.91.5-1.21.30.5-0.5-0.4
Intermittent access intake day 1-15 change0.30.71.61.0-0.81.3-0.50.80.80.3-0.8
Intermittent access intake escalation0.51.12.41.3-1.11.6-0.81.00.90.6-0.8
Intermittent access intake escalation 21.71.94.21.9-1.72.1-1.41.20.70.6-0.6
Intermitt. access day 1 inactive lever presses0.31.02.1-1.21.2-1.51.1-1.1-0.40.30.6
Intermitt. access day 15 inactive lever presses1.02.02.81.7-1.40.5-1.5-1.2-1.41.61.6
Intermitt. access escalation Index0.10.20.40.3-0.3-0.1-0.5-0.3-0.50.60.6
Intermittent access day 1 total infusions1.82.97.11.4-1.22.7-1.32.61.4-0.8-1.3
Intermittent access day 15 total infusions2.63.89.92.0-1.73.1-1.52.61.6-0.1-1.5
Intermittent access terminal intake (last 3 days)2.63.58.92.2-1.93.0-1.92.21.0-0.1-0.9
Intermittent access total infusions1.82.25.61.5-1.32.4-1.32.11.00.1-0.9
Intermittent access day 1 locomotion0.60.82.70.6-0.41.2-0.21.70.8-0.3-0.8
Intermittent access day 15 total locomotion0.40.82.60.2-0.00.90.51.61.1-0.5-1.0
Intermittent access total locomotion1.01.23.11.3-1.01.7-0.51.80.7-0.0-0.7
Intermittent access standard deviation0.20.51.40.8-0.70.9-0.20.60.31.2-0.3
Left kidney weight0.41.84.60.1-0.1-1.2-0.4-2.1-1.81.21.8
Right kidney weight0.20.82.0-0.80.7-1.40.5-1.2-0.60.70.6
Cocaine induced anxiety0.00.00.1-0.20.2-0.20.2-0.20.0-0.20.0
Post-drug Anxiety0.40.41.2-0.80.8-0.40.7-0.10.5-1.1-0.4
Baseline Anxiety0.30.30.7-0.80.8-0.30.6-0.00.4-0.8-0.5
Tail length0.20.82.1-1.21.1-0.81.4-0.60.3-0.5-0.5
Length with tail0.10.41.3-0.40.30.11.10.10.5-0.7-1.1
Length without tail0.20.51.30.9-1.01.1-0.40.60.3-0.2-0.7
Times rat made contact with spout0.30.40.7-0.60.4-0.80.4-0.8-0.80.50.5
Lifetime Intake1.72.15.41.7-1.42.3-1.41.80.70.4-0.6
Liver weight, left0.61.01.8-1.21.1-0.51.20.00.7-1.3-1.0
Liver weight, right0.91.53.80.00.2-1.30.6-1.9-1.71.21.3
Locomotor activity1.11.74.1-1.81.9-1.52.0-0.9-0.1-0.0-0.0
Locomotor testing distance0.40.82.7-1.11.1-1.01.6-0.5-0.1-0.2-0.2
Locomotor testing rearing0.51.02.40.6-0.6-0.3-0.3-1.2-1.61.21.3
Locomotion in novel chamber1.52.03.5-1.81.6-0.81.90.91.3-1.2-1.4
Locomotion in novel chamber post-restriction0.30.51.3-0.30.0-1.00.2-1.2-0.71.00.7
Fecal boli incidents, locomotor time 10.20.31.10.2-0.10.3-0.61.00.6-0.5-0.5
Change in fecal boli incidents, locomotor task0.60.61.30.8-1.10.4-0.6-0.4-0.51.10.4
Time >=10cm from walls, locomotor time 10.20.20.40.6-0.60.2-0.3-0.6-0.4-0.00.2
Bouts of movement, locomotor time 12.52.96.00.6-0.6-0.8-0.8-2.1-2.52.12.4
Total resting periods, locomotor time 11.31.52.80.8-0.8-0.1-1.0-1.3-1.71.51.7
Rest time, locomotor task time 10.20.20.60.2-0.1-0.1-0.5-0.2-0.60.80.6
Distance moved, locomotor task time 10.30.51.4-0.70.5-0.31.20.30.7-0.7-0.8
Vertical activity count, locomotor time 10.51.23.6-1.21.0-0.61.90.20.9-1.2-1.1
Time >=10cm from walls, locomotor time 20.00.00.1-0.0-0.10.20.10.20.2-0.4-0.2
Bouts of movement, locomotor time 22.13.35.7-0.30.3-2.00.2-2.4-2.32.42.3
Total resting periods, locomotor time 22.64.68.5-0.20.2-2.20.0-2.9-2.82.72.8
Rest time, locomotor task time 21.41.83.5-0.40.4-1.1-0.1-1.9-1.81.71.7
Distance moved, locomotor task time 20.40.51.0-0.50.5-0.00.90.70.9-0.7-1.0
Vertical activity count, locomotor time 22.73.75.9-2.21.9-0.82.41.11.9-2.2-2.2
Light reinforcement 10.10.30.5-0.30.5-0.60.7-0.6-0.30.60.5
Light reinforcement 21.01.64.0-2.01.7-1.11.70.40.9-0.7-0.7
Bone: marrow area0.81.73.4-1.11.2-0.31.21.51.8-1.8-1.0
Bone: maximum diameter1.22.24.4-2.02.1-2.12.1-0.50.4-0.4-0.0
Bone: maximum force0.81.32.9-1.51.6-1.31.70.00.6-0.7-0.5
Bone: maximum moment0.61.12.5-1.41.5-1.31.6-0.00.5-0.6-0.4
Mean time between licks in bursts0.61.43.30.6-0.31.3-0.51.81.5-1.5-1.1
Mean num. licks in bursts0.00.00.00.1-0.10.2-0.1-0.1-0.2-0.10.2
Cd content in liver0.70.81.8-0.70.5-1.30.0-1.3-0.91.00.7
Co content in liver1.92.24.9-0.40.4-1.3-0.0-2.2-1.81.72.2
Cu content in liver0.60.71.41.2-1.20.7-0.5-0.5-0.81.00.2
Fe content in liver0.10.20.30.5-0.40.6-0.00.50.3-0.4-0.5
K content in liver0.20.20.50.7-0.40.7-0.10.50.3-0.2-0.3
Mg content in liver0.50.50.90.6-0.40.9-0.30.90.9-0.7-0.7
Mn content in liver0.30.30.70.6-0.50.7-0.80.50.5-0.50.2
Na content in liver0.10.10.2-0.30.2-0.10.3-0.3-0.30.40.2
Rb content in liver0.20.20.80.5-0.30.2-0.9-0.1-0.00.20.5
Se content in liver0.10.10.40.2-0.4-0.0-0.0-0.3-0.60.50.4
Sr content in liver0.20.20.60.1-0.20.80.10.60.2-0.6-0.5
Zn content in liver1.82.03.81.9-1.91.0-1.8-0.5-1.31.30.9
Bone: minimum diameter2.74.98.8-2.02.2-0.41.82.22.8-3.0-2.4
Time in familiar zone, hab. session 11.51.53.7-0.20.0-1.30.2-1.6-1.51.91.2
Time in novel zone, hab. session 10.70.71.61.2-1.01.3-0.90.70.1-0.50.0
Total zone transitions, hab. session 10.50.71.5-0.30.10.60.31.11.2-1.0-1.0
Total locomotion distance, hab. session 10.91.32.8-0.10.11.1-0.01.71.6-1.6-1.2
Locomotion velocity, hab. session 11.21.73.6-0.60.70.80.41.71.9-1.9-1.5
Time in familiar zone, hab. session 22.22.44.11.6-1.6-0.0-1.4-1.3-2.01.91.6
Time in novel zone, hab. session 20.90.92.0-1.00.80.20.61.01.4-1.1-0.9
Total zone transitions, hab. session 20.10.10.20.0-0.0-0.10.50.10.2-0.1-0.5
Total locomotion distance, hab. session 20.40.51.00.10.00.50.41.01.0-0.9-0.9
Locomotion velocity, hab. session 20.40.61.10.10.00.50.51.01.0-1.0-1.0
Novel to familiar place preference ratio0.30.30.6-0.80.7-0.70.4-0.30.3-0.20.7
Novelty place preference0.30.41.0-0.70.7-0.80.3-0.50.00.01.0
Time in novel zone, NPP test0.60.71.7-0.80.7-1.20.4-0.9-0.30.41.3
Total zone transitions, NPP test0.10.10.4-0.00.00.20.50.40.4-0.1-0.6
Total locomotion distance, NPP test0.20.30.50.00.00.50.30.70.6-0.7-0.6
Locomotion velocity, NPP test0.40.51.10.4-0.20.90.11.00.8-0.9-0.8
Intraocular pressure0.91.33.4-1.91.6-0.81.5-0.20.6-1.1-0.4
Delta distance traveled before/after self-admin0.80.92.31.3-0.91.5-1.20.8-0.3-0.00.0
Delta ambulatory time before/after self-admin1.21.53.61.8-1.31.9-1.70.6-0.40.00.2
Parametrial fat weight0.10.30.90.3-0.10.90.10.50.6-0.6-0.4
Pavlov. Cond. lever latency2.02.54.81.4-1.5-0.1-1.4-1.4-1.92.02.2
Pavlov. Cond. magazine entry latency0.40.50.9-0.70.6-0.10.50.70.9-0.6-0.9
Pavlov. Cond. change in total contacts3.23.45.7-2.42.2-1.02.10.81.8-1.9-2.0
Pavlov. Cond. index score1.21.52.3-1.51.4-0.41.30.71.3-1.2-1.5
Pavlov. Cond. latency score1.21.52.3-1.41.4-0.41.40.81.3-1.2-1.5
Pavlov. Cond. lever contacts2.93.46.7-1.41.50.31.51.82.3-2.3-2.6
Pavlov. Cond. magazine entry number0.50.61.61.3-1.00.6-0.9-0.3-0.60.50.8
Pavlov. Cond. intertrial magazine entries1.61.94.42.1-2.01.6-1.90.3-0.50.50.5
Pavlov. Cond. lever-magazine prob. diff.1.11.32.2-1.51.5-0.61.30.51.1-1.0-1.3
Pavlov. Cond. response bias1.62.03.4-1.61.4-0.31.31.11.6-1.5-1.8
Pavlov. Cond. lever latency0.50.71.7-1.31.3-1.10.9-0.50.2-0.30.1
Pavlov. Cond. magazine entry latency0.30.31.3-0.40.20.10.80.50.5-0.4-1.1
Pavlov. Cond. change in total contacts0.71.22.4-0.0-0.10.90.51.61.4-1.3-1.6
Pavlov. Cond. index score0.40.51.30.2-0.40.80.31.00.7-0.7-1.1
Pavlov. Cond. latency score0.30.40.90.4-0.60.80.10.80.5-0.4-1.0
Pavlov. Cond. lever contacts0.50.71.51.1-1.21.2-0.80.90.2-0.1-0.4
Pavlov. Cond. magazine entry number0.50.61.70.6-0.4-0.2-1.0-0.7-0.80.71.3
Pavlov. Cond. intertrial magazine entries0.10.20.6-0.40.5-0.00.00.50.7-0.7-0.4
Pavlov. Cond. lever-magazine prob. diff.0.40.51.00.4-0.60.90.11.00.6-0.5-1.0
Pavlov. Cond. response bias0.60.81.80.3-0.41.00.11.31.0-0.9-1.2
Time in closed arm before self-admin1.11.53.01.7-1.40.9-1.7-0.1-1.10.71.0
Time in closed arm after self-admin1.31.42.5-0.50.3-1.6-0.1-1.5-1.51.41.3
Time in open arm before self-admin0.70.82.0-1.10.9-0.61.4-0.00.8-0.3-1.1
Time in open arm after self-admin1.11.22.2-1.41.4-0.41.50.51.2-0.7-1.0
Bone: periosteal estimation1.53.24.7-2.02.2-1.01.91.32.0-2.1-1.3
Bone: periosteal perimeter0.50.81.8-1.21.4-1.01.10.20.7-0.8-0.2
Bone: post-yield work1.21.83.01.3-1.2-0.1-1.1-1.1-1.71.71.7
Progressive ratio test 1 active lever presses0.81.02.61.3-1.01.6-1.21.10.00.5-0.0
Progressive ratio test 1 breakpoint0.91.12.81.3-1.01.7-1.21.20.10.4-0.1
Progressive ratio test 1 inactive lever presses0.40.51.30.3-0.21.1-0.71.10.8-0.5-0.6
Progressive ratio test 2 active lever presses1.11.33.60.9-0.71.9-0.71.71.1-0.3-1.1
Progressive ratio test 2 breakpoint1.21.43.71.0-0.71.9-0.81.71.1-0.2-1.1
Progressive ratio test 2 inactive lever presses0.00.10.20.2-0.00.5-0.10.1-0.10.20.2
Incentive Sensitization - Responses1.01.53.10.7-0.61.7-0.51.81.4-0.9-1.4
Incentive Sensitization - Breakpoint1.01.32.70.7-0.61.6-0.51.61.3-0.7-1.3
Sum of active levers in priming session hrs 5-60.70.71.31.0-0.91.1-1.00.70.5-0.7-0.4
Progressive ratio1.32.04.3-1.31.0-2.11.5-1.7-0.91.50.9
Food seeking constrained by brief footshock4.35.37.2-2.62.3-0.62.61.92.7-2.3-2.7
Seeking ratio, punishment vs. effort2.23.26.6-0.10.31.7-0.12.62.2-2.5-2.2
Retroperitoneal fat weight0.10.51.0-0.30.20.60.60.71.0-0.8-1.0
Reaction time number correct0.20.30.70.8-0.60.8-0.80.1-0.4-0.50.1
Reaction time mean minus median0.51.11.9-0.91.0-1.40.8-1.3-0.61.11.1
Reaction time mean minus median AUC0.41.12.1-1.11.3-1.41.1-1.2-0.40.60.8
Reaction time num false alarms1.52.14.50.7-0.81.8-0.72.11.6-1.4-1.6
Reaction time num false alarms AUC1.32.03.91.1-1.22.0-1.01.91.3-1.2-1.3
Reaction time trials correct on left0.20.30.70.8-0.60.8-0.80.1-0.4-0.50.1
Reaction time trials on left0.20.30.70.8-0.60.8-0.70.2-0.3-0.60.0
Reaction time mean0.60.92.2-1.51.3-0.70.80.51.2-0.5-0.7
Reaction time mean AUC0.60.92.1-1.41.3-0.70.80.41.2-0.6-0.6
Median of all reaction times1.11.53.3-1.41.1-0.20.71.21.8-1.2-1.4
Reaction time omissions0.10.10.5-0.10.20.10.10.30.6-0.7-0.4
Reaction time false alarm rate0.40.61.50.3-0.60.9-0.31.21.0-0.5-0.8
Reaction time premature initiation rate1.01.43.60.8-0.6-0.5-0.4-1.1-1.41.71.9
Reaction time premature initiations0.91.53.51.2-0.9-0.1-0.8-1.1-1.71.41.9
Std. dev. reaction times0.50.91.8-1.11.1-1.30.7-1.0-0.31.00.9
Reaction time trials completed0.20.30.70.8-0.60.8-0.70.2-0.3-0.60.0
Reaction time trials AUC0.20.40.90.8-0.51.0-0.70.4-0.2-0.7-0.1
Run reversals in cocaine runway, females2.72.75.7-2.42.3-1.82.4-0.50.9-0.2-0.9
Run reversals in cocaine runway, males1.51.53.1-1.61.6-1.11.8-0.01.0-1.1-1.0
Latency to leave start box in cocaine runway0.30.30.60.7-0.70.5-0.5-0.2-0.60.80.5
Latency to leave start box in cocaine runway, F1.61.93.92.0-1.81.2-1.5-0.6-1.21.01.1
Latency to leave start box in cocaine runway, M1.21.12.7-1.71.4-0.81.20.60.9-0.4-1.0
Std. dev. time between licks in bursts0.50.71.30.9-0.71.1-1.01.00.6-0.6-0.2
Total sessions with >9 infusions1.11.32.31.5-1.41.5-1.51.1-0.10.70.1
Short access day 1 total inactive lever presses1.21.64.81.3-1.10.5-1.3-0.7-1.12.21.2
Short access day 10 total inactive lever presses0.10.10.3-0.10.1-0.60.4-0.5-0.00.50.2
Short access day 1 total infusions0.81.12.01.3-1.31.2-1.40.8-0.21.10.2
Short access day 10 total infusions1.62.04.31.9-1.82.1-1.91.20.30.3-0.2
Short access total infusions1.72.25.11.7-1.62.3-1.71.80.60.2-0.6
Short access day 1 locomotion0.10.20.5-0.50.5-0.60.7-0.0-0.10.20.1
Short access day 10 total locomotion0.00.10.3-0.00.00.00.50.50.3-0.1-0.2
Short access total locomotion0.00.00.20.1-0.0-0.00.30.5-0.10.10.1
One hour access (0.3 mA shock)0.91.13.11.2-0.91.8-0.71.20.70.4-0.6
Compulsive drug intake1.72.04.9-2.22.0-1.91.8-0.20.40.1-0.5
One hour access (shock baseline)1.62.57.12.2-1.82.7-1.61.50.4-0.2-0.3
Social response proportion0.70.71.6-0.10.2-0.6-0.3-1.0-1.21.11.3
Social responses1.72.24.50.0-0.1-1.2-0.4-2.1-2.11.62.1
Social time1.41.94.92.2-1.81.2-1.4-0.6-1.30.41.1
Soleus weight0.82.45.7-2.42.3-1.92.1-0.50.5-0.60.3
Bone: stiffness0.20.40.9-0.90.8-0.90.7-0.5-0.1-0.00.3
Tibialis anterior weight7.023.646.6-6.86.5-4.16.70.73.5-3.9-3.2
Time to tail flick, vehicle, before self-admin0.60.61.20.6-0.61.1-1.00.80.7-0.8-0.6
Time to tail flick, vehicle, after self-admin0.81.01.80.9-1.11.3-1.31.30.70.3-0.7
Time to tail flick, test, before self-admin0.20.20.4-0.60.7-0.60.4-0.0-0.20.40.1
Time to tail flick, test, after self-admin1.21.22.51.6-1.30.9-1.2-0.6-1.11.00.9
Delta time to tail flick, vehicle, before/after SA0.90.81.71.3-1.21.1-1.10.70.10.7-0.2
Delta time to tail flick, test, before/after SA0.30.30.70.6-0.60.0-0.2-0.9-0.60.60.6
Tibia length0.41.01.81.2-1.30.3-1.0-0.7-1.31.20.1
Ambulatory time before self-admin1.72.55.4-2.32.0-2.02.3-0.30.7-0.5-0.5
Ambulatory time after self-admin0.20.30.5-0.60.7-0.10.50.50.5-0.7-0.5
Bone: tissue strength1.41.43.71.9-1.81.2-1.40.1-0.80.60.2
Total heroin consumption0.30.41.00.3-0.20.8-0.60.40.6-1.0-0.5
Bone: trabecular number0.20.30.50.6-0.50.6-0.30.70.4-0.6-0.3
Bone: trabecular spacing0.10.10.4-0.60.4-0.30.4-0.10.10.0-0.1
Bone: trabecular thickness0.60.81.31.1-1.11.1-1.10.90.4-0.6-0.4
Bone: trabecular tissue density0.60.81.70.2-0.5-0.5-0.6-1.2-1.21.31.0
Water consumed over 24 hours0.30.40.6-0.70.6-0.80.7-0.7-0.60.30.4
Number of responses in last shaping day0.00.00.10.20.10.20.00.10.10.30.1