Hub : Genes

Stmn2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 LHb gene expression Stmn2 0.34 0.16 5.1e-04 0.06 0.05 0.09 0.06 1.5e-02 2.8e-02 4.7e-03 1.7e-02
2 NAcc gene expression Stmn2 0.02 0.02 1.6e-03 0.02 0.01 0.01 0.01 1.1e-03 4.3e-03 2.6e-03 4.1e-03
3 IC gene expression Stmn2 0.24 0.12 1.7e-05 0.11 0.1 0.09 0.1 2.9e-05 3.9e-05 1.6e-04 4.8e-05
4 pVTA mRNA stability Stmn2 0.07 0.06 1.1e-04 0.05 0.05 0.04 0.04 5.4e-05 8.6e-05 4.3e-04 1.9e-04
5 Brain gene expression Stmn2 0.08 0.05 9.7e-05 0.01 0.03 0.03 0.02 1.6e-02 1.7e-03 1.4e-03 3.2e-03
6 Adipose gene expression Stmn2 0.06 0.04 8.4e-05 0.03 0.03 0.03 0.03 1.1e-04 3.4e-04 7.3e-04 4.0e-04
7 NAcc mRNA stability Stmn2 0.16 0.12 8.9e-07 0.05 0.05 0.05 0.05 2.1e-08 1.2e-07 1.1e-07 2.9e-08
8 Brain mRNA stability Stmn2 0.04 0.04 9.3e-03 0.01 0 0.01 0 4.9e-02 1.0e-01 8.3e-02 1.4e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.71.42.1-1.31.2-1.51.1-1.4-0.81.10.5
Area under the delay curve0.71.12.61.0-0.81.6-1.01.40.8-0.8-0.6
BMI with tail1.55.213.13.6-3.42.4-2.70.8-0.91.40.6
BMI without tail1.47.317.14.1-3.93.1-3.31.2-0.81.60.6
Body weight1.25.111.03.3-3.11.8-3.10.5-1.21.91.5
Weight adjusted by age0.00.10.30.0-0.4-0.3-0.50.10.20.6-0.2
Bone surface0.81.63.4-0.80.6-1.50.4-1.8-1.41.71.2
Bone volume0.91.93.7-1.11.0-1.61.0-1.9-1.31.61.0
Breakpoint value in progressive ratio session0.20.30.60.8-0.60.3-0.4-0.3-0.80.60.6
Number of licking bursts0.10.20.50.5-0.30.7-0.40.40.3-0.4-0.1
Context. condit. distance diff. score0.20.30.60.0-0.20.5-0.30.70.8-0.4-0.6
Locomotion velocity, session 10.00.00.20.3-0.20.40.1-0.0-0.10.1-0.2
Locomotion distance, session 10.70.91.90.6-0.7-0.1-0.8-1.0-1.41.21.2
Locomotion velocity, session 21.41.73.01.7-1.51.0-1.5-0.5-1.41.11.3
Locomotion distance, session 22.02.86.60.7-0.8-0.5-1.0-2.0-2.62.22.1
Locomotion velocity, session 30.50.61.1-0.70.8-0.01.10.60.9-0.8-0.9
Locomotion distance, session 30.40.50.9-0.40.5-1.00.3-1.0-0.60.70.8
Stereotopy head waving bouts, day 30.20.30.8-0.80.8-0.30.9-0.20.10.1-0.2
Stereotopy head waving duration, day 30.40.51.10.4-0.41.1-0.30.90.7-0.6-0.7
Locomotion velocity, session 79.310.217.2-3.03.2-4.03.0-4.2-2.62.42.8
Locomotion distance, session 73.44.38.8-2.52.5-3.02.2-2.3-1.00.91.2
Stereotopy head waving bouts, day 70.30.30.80.6-0.60.7-0.90.1-0.10.50.5
Stereotopy head waving duration, day 70.60.81.81.1-1.01.3-1.20.80.2-0.00.1
Locomotion velocity, session 81.41.73.91.9-1.71.3-2.0-0.0-0.90.70.7
Locomotion distance, session 80.50.71.60.8-0.90.3-1.3-0.6-1.00.90.8
Degree of sensitization distance0.60.61.2-1.01.1-1.01.0-0.8-0.30.10.2
Degree of sensitization stereotypy1.51.63.71.7-1.61.7-1.90.90.10.20.2
Conditioned locomotion0.30.41.1-0.20.2-0.60.5-1.1-0.70.50.6
Cocaine response after cond. corrected0.30.40.9-1.00.9-0.80.9-0.10.2-0.10.1
Cocaine response after cond. not corrected1.21.84.3-2.12.0-1.61.7-0.30.5-0.3-0.2
Cocaine response before conditioning0.80.92.2-1.51.5-1.31.1-0.50.2-0.0-0.0
Saline control response0.20.30.80.00.2-0.50.3-0.9-0.60.90.6
Bone: connectivity density0.91.53.0-1.41.2-1.70.9-1.4-0.81.10.6
Bone: cortical apparent density0.00.10.20.4-0.40.1-0.30.20.00.0-0.2
Bone: cortical area1.21.94.52.0-2.11.6-1.70.1-0.70.90.5
Bone: cortical porosity0.10.10.2-0.1-0.2-0.20.3-0.2-0.30.40.1
Bone: cortical porosity0.10.10.3-0.2-0.1-0.20.5-0.4-0.30.5-0.0
Bone: cortical thickness0.71.22.51.5-1.61.1-1.40.1-0.60.80.8
Bone: cortical thickness2.73.36.82.5-2.52.6-2.31.1-0.0-0.1-0.6
Bone: cortical tissue density0.00.10.10.4-0.40.1-0.30.30.0-0.0-0.2
Condit. Reinf. active minus inactive responses2.83.26.50.9-0.7-1.0-0.5-2.3-2.52.52.4
Condit. Reinf. active-inactive response ratio4.54.99.41.1-0.9-1.3-0.5-2.8-3.13.02.9
Condit. Reinf. active responses2.53.36.40.8-0.6-1.0-0.5-2.3-2.52.52.5
Condit. Reinf. inactive responses0.10.20.50.4-0.50.6-0.70.2-0.10.20.2
Incentive salience index mean3.03.97.41.4-1.2-0.7-0.9-2.3-2.72.72.6
Condit. Reinf. lever presses2.03.05.31.8-1.80.2-1.5-1.4-2.02.12.3
Condit. Reinf. active minus inactive responses1.42.14.5-0.90.8-1.90.7-2.1-1.71.41.5
Condit. Reinf. active-inactive response ratio1.11.73.40.10.0-1.1-0.3-1.8-1.81.51.8
Condit. Reinf. active responses2.53.67.4-1.81.6-2.71.4-2.6-1.71.51.5
Condit. Reinf. inactive responses0.60.92.0-1.01.0-1.41.1-1.1-0.40.50.4
Condit. Reinf. lever presses0.60.91.9-1.10.9-1.40.4-1.3-0.60.50.8
Condit. Reinf. lever reinforcers received2.33.36.6-1.81.6-2.61.3-2.4-1.61.31.4
Conditioned reinforcement - actives0.31.22.6-1.51.4-1.61.4-0.70.10.2-0.0
Conditioned reinforcement - inactives0.20.61.9-0.60.4-1.40.4-1.0-0.80.30.7
Conditioned locomotion0.50.81.6-1.21.1-1.30.8-1.0-0.2-0.10.2
Patch foraging indifference point 0 sec0.30.91.8-1.31.4-0.70.90.10.7-1.1-0.5
Patch foraging indifference point AUC0.20.51.1-0.90.9-1.10.7-0.7-0.20.10.4
Delay disc. indifference point, 0s delay0.30.31.10.2-0.10.5-0.31.10.7-0.7-0.5
Delay disc. indifference point, 16s delay0.20.30.80.9-0.80.9-0.70.20.0-0.10.1
Delay disc. indifference point, 2s delay0.80.91.41.0-0.90.2-1.2-0.3-1.01.21.1
Delay disc. indifference point, 24s delay0.10.20.60.5-0.40.8-0.20.20.2-0.4-0.2
Delay disc. indifference point, 4s delay2.22.34.11.8-1.62.0-1.82.00.8-0.4-0.6
Delay disc. indifference point, 8s delay0.71.12.5-0.10.11.1-0.11.61.4-1.3-1.2
Indifference point function ln k0.41.33.11.4-1.31.8-0.71.30.6-0.8-0.9
Indifference point function log k0.41.33.11.4-1.31.8-0.71.30.6-0.8-0.9
Patch foraging total patch changes 0 sec0.30.91.7-1.21.3-0.40.80.41.0-1.3-0.7
Patch foraging total patch changes 12 sec0.60.91.7-1.31.3-0.50.70.41.0-1.2-0.4
Patch foraging total patch changes 18 sec0.10.20.5-0.50.7-0.10.2-0.10.3-0.6-0.1
Patch foraging total patch changes 24 sec0.10.30.8-0.90.8-0.40.2-0.00.4-0.7-0.3
Patch foraging total patch changes 6 sec0.20.41.0-0.81.0-0.30.40.30.7-0.7-0.3
Patch foraging time to switch 0 sec0.72.64.21.6-1.50.1-1.5-1.4-2.02.01.9
Patch foraging water rate 0 sec0.31.32.8-1.01.00.30.71.21.6-1.2-1.7
Patch foraging water rate 12 sec0.10.30.5-0.70.6-0.00.70.30.6-0.4-0.6
Patch foraging water rate 18 sec0.00.10.4-0.30.4-0.20.60.00.30.2-0.2
Patch foraging water rate 24 sec0.71.02.0-0.00.21.00.21.31.4-1.0-1.4
Patch foraging water rate 6 sec0.71.11.8-0.91.00.11.20.81.3-1.2-1.2
Seeking ratio, delayed vs. immediate footshock2.23.16.3-2.32.5-2.22.5-1.3-0.1-0.80.1
Distance traveled before self-admin1.43.16.62.5-2.32.4-2.60.7-0.30.20.2
Distance traveled after self-admin0.61.12.71.6-1.61.3-1.40.10.0-0.00.1
Extensor digitorum longus weight6.023.851.07.1-6.75.4-7.00.7-2.32.52.0
Bone: elastic displacement0.40.50.9-0.10.2-0.80.5-0.9-0.80.71.0
Bone: elastic work0.30.41.00.2-0.2-0.2-0.7-0.8-0.80.71.0
Bone: endosteal estimation0.71.63.31.0-1.10.2-1.0-1.5-1.81.80.9
Bone: endosteal perimeter0.20.51.00.4-0.50.2-0.7-0.9-1.01.00.4
Epididymis fat weight0.00.10.30.6-0.40.3-0.40.2-0.2-0.00.0
Delta time in closed arm before/after self-admin0.70.72.11.1-0.71.5-1.00.80.0-0.4-0.1
Delta time in open arm before/after self-admin0.20.20.6-0.30.2-0.80.5-0.8-0.50.30.2
Diff in mean of infusions in LGA sessions0.61.22.21.5-1.40.8-1.2-0.4-1.01.10.8
Delay discount exponential model param0.71.02.3-0.80.7-1.50.9-1.4-0.80.80.6
Extinction: sum of active levers before priming0.30.40.7-0.80.8-0.70.8-0.5-0.20.70.0
Active lever presses in extinction session 60.10.10.60.3-0.30.40.1-0.00.2-0.8-0.1
Bone: final force1.11.83.41.7-1.70.9-1.8-0.6-1.31.31.1
Bone: final moment1.01.63.01.6-1.60.9-1.7-0.5-1.11.21.0
Food consumed during 24 hour testing period0.61.12.41.3-1.21.6-1.11.00.6-0.2-0.8
Glucose0.50.92.01.1-1.01.4-1.00.80.6-0.5-0.6
Heart weight0.20.30.6-0.10.10.50.30.50.7-0.6-0.8
Delay discount hyperbolic model param0.81.02.2-1.10.9-1.51.2-1.3-0.50.50.4
Intermittent access intake day 1-15 change0.10.71.6-1.00.8-1.30.5-0.8-0.8-0.30.8
Intermittent access intake escalation0.21.12.4-1.31.1-1.60.8-1.0-0.9-0.60.8
Intermittent access intake escalation 21.11.94.2-1.91.7-2.11.4-1.2-0.7-0.60.6
Intermitt. access day 1 inactive lever presses0.11.02.11.2-1.21.5-1.11.10.4-0.3-0.6
Intermitt. access day 15 inactive lever presses0.42.02.8-1.71.4-0.51.51.21.4-1.6-1.6
Intermitt. access escalation Index0.10.20.4-0.30.30.10.50.30.5-0.6-0.6
Intermittent access day 1 total infusions1.02.97.1-1.41.2-2.71.3-2.6-1.40.81.3
Intermittent access day 15 total infusions1.63.89.9-2.01.7-3.11.5-2.6-1.60.11.5
Intermittent access terminal intake (last 3 days)2.03.58.9-2.21.9-3.01.9-2.2-1.00.10.9
Intermittent access total infusions1.82.25.6-1.51.3-2.41.3-2.1-1.0-0.10.9
Intermittent access day 1 locomotion0.40.82.7-0.60.4-1.20.2-1.7-0.80.30.8
Intermittent access day 15 total locomotion0.20.82.6-0.20.0-0.9-0.5-1.6-1.10.51.0
Intermittent access total locomotion1.01.23.1-1.31.0-1.70.5-1.8-0.70.00.7
Intermittent access standard deviation0.10.51.4-0.80.7-0.90.2-0.6-0.3-1.20.3
Left kidney weight0.21.84.6-0.10.11.20.42.11.8-1.2-1.8
Right kidney weight0.10.82.00.8-0.71.4-0.51.20.6-0.7-0.6
Cocaine induced anxiety0.00.00.10.2-0.20.2-0.20.2-0.00.2-0.0
Post-drug Anxiety0.40.41.20.8-0.80.4-0.70.1-0.51.10.4
Baseline Anxiety0.20.30.70.8-0.80.3-0.60.0-0.40.80.5
Tail length0.10.82.11.2-1.10.8-1.40.6-0.30.50.5
Length with tail0.10.41.30.4-0.3-0.1-1.1-0.1-0.50.71.1
Length without tail0.10.51.3-0.91.0-1.10.4-0.6-0.30.20.7
Times rat made contact with spout0.30.40.70.6-0.40.8-0.40.80.8-0.5-0.5
Lifetime Intake1.72.15.4-1.71.4-2.31.4-1.8-0.7-0.40.6
Liver weight, left0.61.01.81.2-1.10.5-1.2-0.0-0.71.31.0
Liver weight, right0.91.53.8-0.0-0.21.3-0.61.91.7-1.2-1.3
Locomotor activity1.11.74.11.8-1.91.5-2.00.90.10.00.0
Locomotor testing distance0.30.82.71.1-1.11.0-1.60.50.10.20.2
Locomotor testing rearing0.31.02.4-0.60.60.30.31.21.6-1.2-1.3
Locomotion in novel chamber1.52.03.51.8-1.60.8-1.9-0.9-1.31.21.4
Locomotion in novel chamber post-restriction0.20.51.30.3-0.01.0-0.21.20.7-1.0-0.7
Fecal boli incidents, locomotor time 10.10.31.1-0.20.1-0.30.6-1.0-0.60.50.5
Change in fecal boli incidents, locomotor task0.50.61.3-0.81.1-0.40.60.40.5-1.1-0.4
Time >=10cm from walls, locomotor time 10.10.20.4-0.60.6-0.20.30.60.40.0-0.2
Bouts of movement, locomotor time 12.22.96.0-0.60.60.80.82.12.5-2.1-2.4
Total resting periods, locomotor time 11.31.52.8-0.80.80.11.01.31.7-1.5-1.7
Rest time, locomotor task time 10.10.20.6-0.20.10.10.50.20.6-0.8-0.6
Distance moved, locomotor task time 10.20.51.40.7-0.50.3-1.2-0.3-0.70.70.8
Vertical activity count, locomotor time 10.21.23.61.2-1.00.6-1.9-0.2-0.91.21.1
Time >=10cm from walls, locomotor time 20.00.00.10.00.1-0.2-0.1-0.2-0.20.40.2
Bouts of movement, locomotor time 21.03.35.70.3-0.32.0-0.22.42.3-2.4-2.3
Total resting periods, locomotor time 21.14.68.50.2-0.22.2-0.02.92.8-2.7-2.8
Rest time, locomotor task time 21.01.83.50.4-0.41.10.11.91.8-1.7-1.7
Distance moved, locomotor task time 20.40.51.00.5-0.50.0-0.9-0.7-0.90.71.0
Vertical activity count, locomotor time 21.63.75.92.2-1.90.8-2.4-1.1-1.92.22.2
Light reinforcement 10.10.30.50.3-0.50.6-0.70.60.3-0.6-0.5
Light reinforcement 20.71.64.02.0-1.71.1-1.7-0.4-0.90.70.7
Bone: marrow area0.71.73.41.1-1.20.3-1.2-1.5-1.81.81.0
Bone: maximum diameter1.12.24.42.0-2.12.1-2.10.5-0.40.40.0
Bone: maximum force0.71.32.91.5-1.61.3-1.7-0.0-0.60.70.5
Bone: maximum moment0.61.12.51.4-1.51.3-1.60.0-0.50.60.4
Mean time between licks in bursts0.21.43.3-0.60.3-1.30.5-1.8-1.51.51.1
Mean num. licks in bursts0.00.00.0-0.10.1-0.20.10.10.20.1-0.2
Cd content in liver0.70.81.80.7-0.51.3-0.01.30.9-1.0-0.7
Co content in liver1.92.24.90.4-0.41.30.02.21.8-1.7-2.2
Cu content in liver0.60.71.4-1.21.2-0.70.50.50.8-1.0-0.2
Fe content in liver0.10.20.3-0.50.4-0.60.0-0.5-0.30.40.5
K content in liver0.20.20.5-0.70.4-0.70.1-0.5-0.30.20.3
Mg content in liver0.40.50.9-0.60.4-0.90.3-0.9-0.90.70.7
Mn content in liver0.30.30.7-0.60.5-0.70.8-0.5-0.50.5-0.2
Na content in liver0.10.10.20.3-0.20.1-0.30.30.3-0.4-0.2
Rb content in liver0.20.20.8-0.50.3-0.20.90.10.0-0.2-0.5
Se content in liver0.10.10.4-0.20.40.00.00.30.6-0.5-0.4
Sr content in liver0.20.20.6-0.10.2-0.8-0.1-0.6-0.20.60.5
Zn content in liver1.72.03.8-1.91.9-1.01.80.51.3-1.3-0.9
Bone: minimum diameter2.64.98.82.0-2.20.4-1.8-2.2-2.83.02.4
Time in familiar zone, hab. session 11.31.53.70.2-0.01.3-0.21.61.5-1.9-1.2
Time in novel zone, hab. session 10.60.71.6-1.21.0-1.30.9-0.7-0.10.5-0.0
Total zone transitions, hab. session 10.50.71.50.3-0.1-0.6-0.3-1.1-1.21.01.0
Total locomotion distance, hab. session 10.91.32.80.1-0.1-1.10.0-1.7-1.61.61.2
Locomotion velocity, hab. session 11.21.73.60.6-0.7-0.8-0.4-1.7-1.91.91.5
Time in familiar zone, hab. session 22.12.44.1-1.61.60.01.41.32.0-1.9-1.6
Time in novel zone, hab. session 20.80.92.01.0-0.8-0.2-0.6-1.0-1.41.10.9
Total zone transitions, hab. session 20.10.10.2-0.00.00.1-0.5-0.1-0.20.10.5
Total locomotion distance, hab. session 20.40.51.0-0.1-0.0-0.5-0.4-1.0-1.00.90.9
Locomotion velocity, hab. session 20.40.61.1-0.1-0.0-0.5-0.5-1.0-1.01.01.0
Novel to familiar place preference ratio0.20.30.60.8-0.70.7-0.40.3-0.30.2-0.7
Novelty place preference0.30.41.00.7-0.70.8-0.30.5-0.0-0.0-1.0
Time in novel zone, NPP test0.50.71.70.8-0.71.2-0.40.90.3-0.4-1.3
Total zone transitions, NPP test0.10.10.40.0-0.0-0.2-0.5-0.4-0.40.10.6
Total locomotion distance, NPP test0.20.30.5-0.0-0.0-0.5-0.3-0.7-0.60.70.6
Locomotion velocity, NPP test0.40.51.1-0.40.2-0.9-0.1-1.0-0.80.90.8
Intraocular pressure0.81.33.41.9-1.60.8-1.50.2-0.61.10.4
Delta distance traveled before/after self-admin0.80.92.3-1.30.9-1.51.2-0.80.30.0-0.0
Delta ambulatory time before/after self-admin0.91.53.6-1.81.3-1.91.7-0.60.4-0.0-0.2
Parametrial fat weight0.10.30.9-0.30.1-0.9-0.1-0.5-0.60.60.4
Pavlov. Cond. lever latency2.02.54.8-1.41.50.11.41.41.9-2.0-2.2
Pavlov. Cond. magazine entry latency0.40.50.90.7-0.60.1-0.5-0.7-0.90.60.9
Pavlov. Cond. change in total contacts3.23.45.72.4-2.21.0-2.1-0.8-1.81.92.0
Pavlov. Cond. index score1.21.52.31.5-1.40.4-1.3-0.7-1.31.21.5
Pavlov. Cond. latency score1.21.52.31.4-1.40.4-1.4-0.8-1.31.21.5
Pavlov. Cond. lever contacts2.93.46.71.4-1.5-0.3-1.5-1.8-2.32.32.6
Pavlov. Cond. magazine entry number0.50.61.6-1.31.0-0.60.90.30.6-0.5-0.8
Pavlov. Cond. intertrial magazine entries1.61.94.4-2.12.0-1.61.9-0.30.5-0.5-0.5
Pavlov. Cond. lever-magazine prob. diff.1.01.32.21.5-1.50.6-1.3-0.5-1.11.01.3
Pavlov. Cond. response bias1.62.03.41.6-1.40.3-1.3-1.1-1.61.51.8
Pavlov. Cond. lever latency0.50.71.71.3-1.31.1-0.90.5-0.20.3-0.1
Pavlov. Cond. magazine entry latency0.20.31.30.4-0.2-0.1-0.8-0.5-0.50.41.1
Pavlov. Cond. change in total contacts0.51.22.40.00.1-0.9-0.5-1.6-1.41.31.6
Pavlov. Cond. index score0.30.51.3-0.20.4-0.8-0.3-1.0-0.70.71.1
Pavlov. Cond. latency score0.20.40.9-0.40.6-0.8-0.1-0.8-0.50.41.0
Pavlov. Cond. lever contacts0.50.71.5-1.11.2-1.20.8-0.9-0.20.10.4
Pavlov. Cond. magazine entry number0.50.61.7-0.60.40.21.00.70.8-0.7-1.3
Pavlov. Cond. intertrial magazine entries0.10.20.60.4-0.50.0-0.0-0.5-0.70.70.4
Pavlov. Cond. lever-magazine prob. diff.0.30.51.0-0.40.6-0.9-0.1-1.0-0.60.51.0
Pavlov. Cond. response bias0.60.81.8-0.30.4-1.0-0.1-1.3-1.00.91.2
Time in closed arm before self-admin0.81.53.0-1.71.4-0.91.70.11.1-0.7-1.0
Time in closed arm after self-admin1.21.42.50.5-0.31.60.11.51.5-1.4-1.3
Time in open arm before self-admin0.70.82.01.1-0.90.6-1.40.0-0.80.31.1
Time in open arm after self-admin1.11.22.21.4-1.40.4-1.5-0.5-1.20.71.0
Bone: periosteal estimation1.33.24.72.0-2.21.0-1.9-1.3-2.02.11.3
Bone: periosteal perimeter0.40.81.81.2-1.41.0-1.1-0.2-0.70.80.2
Bone: post-yield work1.01.83.0-1.31.20.11.11.11.7-1.7-1.7
Progressive ratio test 1 active lever presses0.61.02.6-1.31.0-1.61.2-1.1-0.0-0.50.0
Progressive ratio test 1 breakpoint0.61.12.8-1.31.0-1.71.2-1.2-0.1-0.40.1
Progressive ratio test 1 inactive lever presses0.20.51.3-0.30.2-1.10.7-1.1-0.80.50.6
Progressive ratio test 2 active lever presses0.91.33.6-0.90.7-1.90.7-1.7-1.10.31.1
Progressive ratio test 2 breakpoint1.11.43.7-1.00.7-1.90.8-1.7-1.10.21.1
Progressive ratio test 2 inactive lever presses0.00.10.2-0.20.0-0.50.1-0.10.1-0.2-0.2
Incentive Sensitization - Responses0.51.53.1-0.70.6-1.70.5-1.8-1.40.91.4
Incentive Sensitization - Breakpoint0.61.32.7-0.70.6-1.60.5-1.6-1.30.71.3
Sum of active levers in priming session hrs 5-60.70.71.3-1.00.9-1.11.0-0.7-0.50.70.4
Progressive ratio0.72.04.31.3-1.02.1-1.51.70.9-1.5-0.9
Food seeking constrained by brief footshock4.25.37.22.6-2.30.6-2.6-1.9-2.72.32.7
Seeking ratio, punishment vs. effort1.43.26.60.1-0.3-1.70.1-2.6-2.22.52.2
Retroperitoneal fat weight0.10.51.00.3-0.2-0.6-0.6-0.7-1.00.81.0
Reaction time number correct0.10.30.7-0.80.6-0.80.8-0.10.40.5-0.1
Reaction time mean minus median0.21.11.90.9-1.01.4-0.81.30.6-1.1-1.1
Reaction time mean minus median AUC0.21.12.11.1-1.31.4-1.11.20.4-0.6-0.8
Reaction time num false alarms1.22.14.5-0.70.8-1.80.7-2.1-1.61.41.6
Reaction time num false alarms AUC0.92.03.9-1.11.2-2.01.0-1.9-1.31.21.3
Reaction time trials correct on left0.10.30.7-0.80.6-0.80.8-0.10.40.5-0.1
Reaction time trials on left0.10.30.7-0.80.6-0.80.7-0.20.30.6-0.0
Reaction time mean0.40.92.21.5-1.30.7-0.8-0.5-1.20.50.7
Reaction time mean AUC0.40.92.11.4-1.30.7-0.8-0.4-1.20.60.6
Median of all reaction times1.01.53.31.4-1.10.2-0.7-1.2-1.81.21.4
Reaction time omissions0.10.10.50.1-0.2-0.1-0.1-0.3-0.60.70.4
Reaction time false alarm rate0.40.61.5-0.30.6-0.90.3-1.2-1.00.50.8
Reaction time premature initiation rate0.91.43.6-0.80.60.50.41.11.4-1.7-1.9
Reaction time premature initiations0.51.53.5-1.20.90.10.81.11.7-1.4-1.9
Std. dev. reaction times0.30.91.81.1-1.11.3-0.71.00.3-1.0-0.9
Reaction time trials completed0.10.30.7-0.80.6-0.80.7-0.20.30.6-0.0
Reaction time trials AUC0.10.40.9-0.80.5-1.00.7-0.40.20.70.1
Run reversals in cocaine runway, females2.42.75.72.4-2.31.8-2.40.5-0.90.20.9
Run reversals in cocaine runway, males1.41.53.11.6-1.61.1-1.80.0-1.01.11.0
Latency to leave start box in cocaine runway0.20.30.6-0.70.7-0.50.50.20.6-0.8-0.5
Latency to leave start box in cocaine runway, F1.51.93.9-2.01.8-1.21.50.61.2-1.0-1.1
Latency to leave start box in cocaine runway, M1.21.12.71.7-1.40.8-1.2-0.6-0.90.41.0
Std. dev. time between licks in bursts0.40.71.3-0.90.7-1.11.0-1.0-0.60.60.2
Total sessions with >9 infusions1.01.32.3-1.51.4-1.51.5-1.10.1-0.7-0.1
Short access day 1 total inactive lever presses0.81.64.8-1.31.1-0.51.30.71.1-2.2-1.2
Short access day 10 total inactive lever presses0.00.10.30.1-0.10.6-0.40.50.0-0.5-0.2
Short access day 1 total infusions0.61.12.0-1.31.3-1.21.4-0.80.2-1.1-0.2
Short access day 10 total infusions1.22.04.3-1.91.8-2.11.9-1.2-0.3-0.30.2
Short access total infusions1.62.25.1-1.71.6-2.31.7-1.8-0.6-0.20.6
Short access day 1 locomotion0.10.20.50.5-0.50.6-0.70.00.1-0.2-0.1
Short access day 10 total locomotion0.00.10.30.0-0.0-0.0-0.5-0.5-0.30.10.2
Short access total locomotion0.00.00.2-0.10.00.0-0.3-0.50.1-0.1-0.1
One hour access (0.3 mA shock)0.91.13.1-1.20.9-1.80.7-1.2-0.7-0.40.6
Compulsive drug intake1.42.04.92.2-2.01.9-1.80.2-0.4-0.10.5
One hour access (shock baseline)1.02.57.1-2.21.8-2.71.6-1.5-0.40.20.3
Social response proportion0.60.71.60.1-0.20.60.31.01.2-1.1-1.3
Social responses1.72.24.5-0.00.11.20.42.12.1-1.6-2.1
Social time1.21.94.9-2.21.8-1.21.40.61.3-0.4-1.1
Soleus weight0.82.45.72.4-2.31.9-2.10.5-0.50.6-0.3
Bone: stiffness0.20.40.90.9-0.80.9-0.70.50.10.0-0.3
Tibialis anterior weight6.923.646.66.8-6.54.1-6.7-0.7-3.53.93.2
Time to tail flick, vehicle, before self-admin0.50.61.2-0.60.6-1.11.0-0.8-0.70.80.6
Time to tail flick, vehicle, after self-admin0.51.01.8-0.91.1-1.31.3-1.3-0.7-0.30.7
Time to tail flick, test, before self-admin0.20.20.40.6-0.70.6-0.40.00.2-0.4-0.1
Time to tail flick, test, after self-admin1.21.22.5-1.61.3-0.91.20.61.1-1.0-0.9
Delta time to tail flick, vehicle, before/after SA0.80.81.7-1.31.2-1.11.1-0.7-0.1-0.70.2
Delta time to tail flick, test, before/after SA0.30.30.7-0.60.6-0.00.20.90.6-0.6-0.6
Tibia length0.41.01.8-1.21.3-0.31.00.71.3-1.2-0.1
Ambulatory time before self-admin0.82.55.42.3-2.02.0-2.30.3-0.70.50.5
Ambulatory time after self-admin0.20.30.50.6-0.70.1-0.5-0.5-0.50.70.5
Bone: tissue strength1.31.43.7-1.91.8-1.21.4-0.10.8-0.6-0.2
Total heroin consumption0.30.41.0-0.30.2-0.80.6-0.4-0.61.00.5
Bone: trabecular number0.10.30.5-0.60.5-0.60.3-0.7-0.40.60.3
Bone: trabecular spacing0.10.10.40.6-0.40.3-0.40.1-0.1-0.00.1
Bone: trabecular thickness0.60.81.3-1.11.1-1.11.1-0.9-0.40.60.4
Bone: trabecular tissue density0.50.81.7-0.20.50.50.61.21.2-1.3-1.0
Water consumed over 24 hours0.20.40.60.7-0.60.8-0.70.70.6-0.3-0.4
Number of responses in last shaping day0.00.00.1-0.2-0.1-0.2-0.0-0.1-0.1-0.3-0.1