Hub : Genes

Bhlhe22

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	Bhlhe22	0.28	0.15	0.0e+00	0.13	0.13	0.13	0.13	1.3e-18	2.1e-19	8.0e-19	2.1e-19
2	Brain	gene expression	Bhlhe22	0.08	0.05	8.6e-06	0.05	0.04	0.04	0.04	1.8e-05	1.2e-04	4.5e-05	6.2e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Bone: apparent density	1.3	2.3	2.4	-1.5	1.5
Area under the delay curve	0.8	0.9	1.2	1.1	-0.8
BMI with tail	2.7	9.5	10.2	3.2	-3.0
BMI without tail	2.3	6.9	7.0	2.6	-2.6
Body weight	2.8	12.3	13.3	3.6	-3.4
Weight adjusted by age	0.4	0.6	0.7	0.8	-0.8
Bone surface	0.0	0.0	0.0	-0.1	0.2
Bone volume	0.0	0.0	0.1	-0.2	0.3
Breakpoint value in progressive ratio session	0.4	0.5	0.6	0.7	-0.7
Number of licking bursts	2.0	3.3	3.4	1.8	-1.8
Context. condit. distance diff. score	0.6	0.7	0.8	0.9	-0.8
Locomotion velocity, session 1	0.3	0.3	0.3	0.5	-0.6
Locomotion distance, session 1	0.0	0.0	0.0	0.2	-0.2
Locomotion velocity, session 2	2.7	3.2	3.2	1.8	-1.8
Locomotion distance, session 2	0.0	0.0	0.1	0.1	-0.3
Locomotion velocity, session 3	1.1	1.2	1.4	1.0	-1.2
Locomotion distance, session 3	0.7	0.8	1.0	0.8	-1.0
Stereotopy head waving bouts, day 3	0.2	0.2	0.3	-0.4	0.6
Stereotopy head waving duration, day 3	0.4	0.5	0.7	-0.6	0.8
Locomotion velocity, session 7	2.0	2.2	2.2	-1.5	1.5
Locomotion distance, session 7	2.0	2.6	2.9	-1.7	1.5
Stereotopy head waving bouts, day 7	1.3	1.5	1.7	1.3	-1.1
Stereotopy head waving duration, day 7	0.6	0.7	0.9	0.9	-0.7
Locomotion velocity, session 8	1.9	2.3	2.3	1.5	-1.5
Locomotion distance, session 8	2.0	3.0	3.0	1.7	-1.7
Degree of sensitization distance	4.6	4.8	4.8	-2.2	2.2
Degree of sensitization stereotypy	4.0	4.4	4.7	2.2	-2.0
Conditioned locomotion	1.7	1.9	2.2	-1.3	1.5
Cocaine response after cond. corrected	0.2	0.3	0.3	-0.6	0.4
Cocaine response after cond. not corrected	0.2	0.3	0.3	-0.6	0.5
Cocaine response before conditioning	0.2	0.2	0.3	-0.4	0.5
Saline control response	0.3	0.4	0.5	0.7	-0.6
Bone: connectivity density	1.9	3.0	3.1	-1.7	1.8
Bone: cortical apparent density	0.8	1.0	1.1	1.0	-1.0
Bone: cortical area	0.8	1.2	1.3	1.2	-1.0
Bone: cortical porosity	0.6	0.6	0.8	-0.9	0.7
Bone: cortical porosity	0.2	0.2	0.2	-0.5	0.3
Bone: cortical thickness	0.0	0.0	0.0	0.1	0.1
Bone: cortical thickness	1.1	1.3	1.4	1.1	-1.2
Bone: cortical tissue density	0.9	1.2	1.3	1.1	-1.1
Condit. Reinf. active minus inactive responses	0.1	0.1	0.1	0.3	-0.3
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.0	0.0	0.0
Condit. Reinf. active responses	0.2	0.2	0.3	0.4	-0.5
Condit. Reinf. inactive responses	0.4	0.5	0.7	0.6	-0.8
Incentive salience index mean	0.3	0.3	0.4	0.5	-0.6
Condit. Reinf. lever presses	0.3	0.4	0.6	0.5	-0.8
Condit. Reinf. active minus inactive responses	0.5	0.6	0.7	0.8	-0.7
Condit. Reinf. active-inactive response ratio	0.2	0.3	0.3	0.5	-0.5
Condit. Reinf. active responses	0.2	0.3	0.4	0.6	-0.5
Condit. Reinf. inactive responses	0.1	0.2	0.2	0.4	-0.4
Condit. Reinf. lever presses	0.3	0.5	0.5	-0.7	0.7
Condit. Reinf. lever reinforcers received	0.2	0.2	0.2	0.5	-0.4
Conditioned reinforcement - actives	0.1	0.2	0.4	-0.1	0.6
Conditioned reinforcement - inactives	0.0	0.0	0.0	0.1	-0.1
Conditioned locomotion	0.4	0.6	0.7	0.8	-0.7
Patch foraging indifference point 0 sec	0.1	0.2	0.3	0.3	-0.5
Patch foraging indifference point AUC	0.4	0.6	0.8	-0.9	0.7
Delay disc. indifference point, 0s delay	0.6	0.7	0.8	0.7	-0.9
Delay disc. indifference point, 16s delay	0.2	0.2	0.5	0.0	0.7
Delay disc. indifference point, 2s delay	0.8	0.9	1.5	1.2	-0.6
Delay disc. indifference point, 24s delay	0.9	1.0	1.5	-0.7	1.2
Delay disc. indifference point, 4s delay	2.7	2.9	3.8	1.4	-1.9
Delay disc. indifference point, 8s delay	0.7	0.8	0.8	0.9	-0.9
Indifference point function ln k	0.7	1.1	1.3	1.0	-1.1
Indifference point function log k	0.7	1.1	1.3	1.0	-1.1
Patch foraging total patch changes 0 sec	0.2	0.5	0.7	0.5	-0.8
Patch foraging total patch changes 12 sec	0.0	0.0	0.0	-0.2	0.1
Patch foraging total patch changes 18 sec	0.0	0.0	0.1	-0.2	-0.1
Patch foraging total patch changes 24 sec	0.3	0.4	0.4	-0.7	0.6
Patch foraging total patch changes 6 sec	0.1	0.1	0.1	0.4	-0.4
Patch foraging time to switch 0 sec	0.2	0.4	0.6	0.8	-0.4
Patch foraging water rate 0 sec	0.0	0.1	0.1	-0.3	-0.2
Patch foraging water rate 12 sec	1.1	2.3	3.1	-1.8	1.2
Patch foraging water rate 18 sec	0.7	1.1	2.0	-1.4	0.5
Patch foraging water rate 24 sec	0.4	0.5	0.9	-0.9	0.4
Patch foraging water rate 6 sec	0.2	0.3	0.6	-0.1	-0.8
Seeking ratio, delayed vs. immediate footshock	2.0	2.4	3.5	-1.1	1.9
Distance traveled before self-admin	6.4	8.4	9.4	2.7	-3.1
Distance traveled after self-admin	7.2	8.8	8.9	3.0	-3.0
Extensor digitorum longus weight	6.7	26.5	27.6	5.0	-5.3
Bone: elastic displacement	3.4	4.0	4.8	-2.2	1.8
Bone: elastic work	1.0	1.4	1.6	-1.3	1.1
Bone: endosteal estimation	1.4	3.0	3.1	1.7	-1.8
Bone: endosteal perimeter	2.2	4.6	5.2	2.3	-2.0
Epididymis fat weight	3.3	11.1	11.5	3.3	-3.4
Delta time in closed arm before/after self-admin	0.6	0.6	1.0	-0.4	1.0
Delta time in open arm before/after self-admin	0.6	0.6	0.6	0.8	-0.8
Diff in mean of infusions in LGA sessions	0.5	0.6	1.2	-1.1	0.3
Delay discount exponential model param	0.7	0.7	1.0	-1.0	0.7
Extinction: sum of active levers before priming	0.7	0.8	1.4	1.2	-0.4
Active lever presses in extinction session 6	1.1	1.1	1.2	1.0	-1.1
Bone: final force	1.7	2.7	2.9	1.7	-1.6
Bone: final moment	1.5	2.4	2.5	1.6	-1.5
Food consumed during 24 hour testing period	3.8	5.2	5.8	2.2	-2.4
Glucose	0.4	0.6	0.6	0.7	-0.8
Heart weight	1.1	1.7	1.8	1.3	-1.3
Delay discount hyperbolic model param	1.0	1.1	1.3	-1.2	0.9
Intermittent access intake day 1-15 change	0.0	0.0	0.0	-0.1	0.0
Intermittent access intake escalation	0.0	0.0	0.0	-0.1	0.1
Intermittent access intake escalation 2	0.2	0.2	0.3	-0.5	0.3
Intermitt. access day 1 inactive lever presses	0.1	0.3	0.4	0.7	-0.4
Intermitt. access day 15 inactive lever presses	0.0	0.1	0.1	-0.3	0.2
Intermitt. access escalation Index	0.4	0.5	0.6	-0.7	0.8
Intermittent access day 1 total infusions	0.0	0.0	0.1	-0.3	0.1
Intermittent access day 15 total infusions	0.5	0.7	1.2	-1.1	0.6
Intermittent access terminal intake (last 3 days)	0.1	0.2	0.3	-0.6	0.0
Intermittent access total infusions	0.3	0.4	0.6	-0.8	0.4
Intermittent access day 1 locomotion	0.5	0.7	0.9	0.9	-0.7
Intermittent access day 15 total locomotion	0.2	0.4	0.6	0.4	-0.8
Intermittent access total locomotion	0.4	0.4	0.5	0.6	-0.7
Intermittent access standard deviation	0.1	0.2	0.5	-0.2	-0.7
Left kidney weight	0.3	1.3	1.8	1.4	-0.9
Right kidney weight	0.8	3.9	4.4	2.1	-1.8
Cocaine induced anxiety	0.1	0.1	0.2	-0.4	0.1
Post-drug Anxiety	0.2	0.2	0.2	-0.4	0.4
Baseline Anxiety	0.1	0.1	0.2	0.4	-0.2
Tail length	0.1	0.5	0.6	0.7	-0.8
Length with tail	0.8	3.6	4.3	2.1	-1.7
Length without tail	1.0	3.1	3.7	1.9	-1.6
Times rat made contact with spout	4.6	5.2	5.3	2.3	-2.3
Lifetime Intake	0.2	0.2	0.4	-0.6	0.4
Liver weight, left	1.8	2.9	3.4	1.6	-1.9
Liver weight, right	5.1	9.0	9.6	3.1	-2.9
Locomotor activity	0.9	1.4	1.9	1.4	-0.9
Locomotor testing distance	1.1	2.1	2.7	1.6	-1.2
Locomotor testing rearing	0.0	0.0	0.1	0.1	0.3
Locomotion in novel chamber	0.1	0.1	0.1	0.2	-0.3
Locomotion in novel chamber post-restriction	0.2	0.3	0.5	-0.1	0.7
Fecal boli incidents, locomotor time 1	0.3	0.5	0.9	1.0	-0.3
Change in fecal boli incidents, locomotor task	0.3	0.3	0.4	-0.7	0.3
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.0	-0.1	0.1
Bouts of movement, locomotor time 1	0.2	0.2	0.5	-0.0	0.7
Total resting periods, locomotor time 1	0.3	0.3	0.6	-0.1	0.8
Rest time, locomotor task time 1	0.0	0.1	0.1	0.3	0.2
Distance moved, locomotor task time 1	0.1	0.2	0.3	0.3	-0.5
Vertical activity count, locomotor time 1	0.1	0.2	0.4	0.3	-0.6
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.0	-0.1	0.1
Bouts of movement, locomotor time 2	0.2	0.4	0.4	-0.6	0.6
Total resting periods, locomotor time 2	0.1	0.2	0.2	-0.5	0.4
Rest time, locomotor task time 2	0.0	0.0	0.0	-0.1	0.1
Distance moved, locomotor task time 2	0.1	0.2	0.2	-0.3	0.5
Vertical activity count, locomotor time 2	0.1	0.2	0.2	0.4	-0.5
Light reinforcement 1	1.0	2.5	3.2	1.8	-1.4
Light reinforcement 2	3.6	5.6	6.3	2.5	-2.2
Bone: marrow area	1.3	2.9	3.0	1.7	-1.7
Bone: maximum diameter	1.5	2.8	3.1	1.8	-1.6
Bone: maximum force	1.4	2.5	2.8	1.7	-1.5
Bone: maximum moment	1.2	2.0	2.3	1.5	-1.3
Mean time between licks in bursts	0.0	0.0	0.0	-0.1	0.1
Mean num. licks in bursts	0.2	0.3	0.3	-0.5	0.5
Cd content in liver	1.0	1.1	1.3	0.9	-1.1
Co content in liver	0.8	0.9	1.0	1.0	-1.0
Cu content in liver	0.3	0.3	0.4	-0.4	0.6
Fe content in liver	0.1	0.1	0.1	0.3	0.2
K content in liver	0.6	0.5	0.7	-0.6	0.9
Mg content in liver	0.5	0.5	0.5	-0.6	0.7
Mn content in liver	0.0	0.0	0.1	-0.0	0.3
Na content in liver	0.8	0.9	1.2	1.1	-0.8
Rb content in liver	0.8	1.0	1.0	-1.0	1.0
Se content in liver	0.1	0.1	0.1	0.2	0.4
Sr content in liver	1.5	1.3	1.4	-1.1	1.2
Zn content in liver	0.1	0.2	0.2	-0.5	0.3
Bone: minimum diameter	0.3	0.5	0.5	0.7	-0.6
Time in familiar zone, hab. session 1	0.0	0.0	0.1	-0.2	0.2
Time in novel zone, hab. session 1	0.3	0.3	0.3	0.5	-0.6
Total zone transitions, hab. session 1	0.1	0.1	0.2	0.3	-0.4
Total locomotion distance, hab. session 1	0.1	0.2	0.2	0.5	-0.4
Locomotion velocity, hab. session 1	0.2	0.3	0.3	0.6	-0.5
Time in familiar zone, hab. session 2	0.6	0.7	0.7	-0.8	0.8
Time in novel zone, hab. session 2	0.1	0.1	0.1	-0.4	0.3
Total zone transitions, hab. session 2	0.8	1.0	1.0	1.0	-1.0
Total locomotion distance, hab. session 2	0.1	0.2	0.2	0.4	-0.5
Locomotion velocity, hab. session 2	0.3	0.3	0.4	0.6	-0.6
Novel to familiar place preference ratio	1.9	2.1	2.2	-1.4	1.5
Novelty place preference	1.8	1.9	2.0	-1.3	1.4
Time in novel zone, NPP test	1.4	1.4	1.6	-1.1	1.3
Total zone transitions, NPP test	0.1	0.1	0.2	0.3	-0.4
Total locomotion distance, NPP test	0.2	0.2	0.2	0.4	-0.5
Locomotion velocity, NPP test	0.0	0.0	0.0	-0.1	0.0
Intraocular pressure	1.4	2.0	2.9	1.7	-1.0
Delta distance traveled before/after self-admin	0.2	0.3	0.3	-0.6	0.4
Delta ambulatory time before/after self-admin	1.0	1.2	1.4	-1.2	1.1
Parametrial fat weight	2.1	5.0	5.7	2.1	-2.4
Pavlov. Cond. lever latency	0.1	0.1	0.1	-0.2	0.3
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	-0.0	-0.2
Pavlov. Cond. change in total contacts	1.6	1.7	1.8	1.3	-1.3
Pavlov. Cond. index score	0.6	0.7	0.9	0.7	-0.9
Pavlov. Cond. latency score	0.4	0.5	0.6	0.6	-0.8
Pavlov. Cond. lever contacts	0.1	0.1	0.2	0.3	-0.4
Pavlov. Cond. magazine entry number	0.5	0.6	0.7	-0.6	0.9
Pavlov. Cond. intertrial magazine entries	0.3	0.3	0.4	-0.6	0.6
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.1	1.3	0.9	-1.1
Pavlov. Cond. response bias	0.5	0.6	0.7	0.6	-0.9
Pavlov. Cond. lever latency	0.0	0.0	0.0	0.0	-0.2
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	0.2	-0.2
Pavlov. Cond. change in total contacts	0.0	0.0	0.0	0.0	0.2
Pavlov. Cond. index score	0.0	0.0	0.1	0.2	-0.1
Pavlov. Cond. latency score	0.0	0.0	0.0	0.2	-0.1
Pavlov. Cond. lever contacts	0.0	0.0	0.0	-0.0	0.2
Pavlov. Cond. magazine entry number	0.0	0.0	0.0	-0.2	0.0
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.4	-0.7	0.5
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.1	0.3	-0.2
Pavlov. Cond. response bias	0.0	0.0	0.0	0.2	0.0
Time in closed arm before self-admin	0.4	0.5	1.0	-1.0	0.3
Time in closed arm after self-admin	0.7	0.8	0.9	-0.8	0.9
Time in open arm before self-admin	0.0	0.0	0.0	-0.1	0.2
Time in open arm after self-admin	2.7	2.9	3.8	1.9	-1.4
Bone: periosteal estimation	1.4	2.9	3.0	1.7	-1.7
Bone: periosteal perimeter	1.9	3.3	3.9	2.0	-1.6
Bone: post-yield work	0.8	1.2	1.3	1.1	-1.0
Progressive ratio test 1 active lever presses	0.3	0.4	0.4	0.6	-0.6
Progressive ratio test 1 breakpoint	0.3	0.4	0.4	0.6	-0.6
Progressive ratio test 1 inactive lever presses	0.5	0.8	1.2	-0.6	1.1
Progressive ratio test 2 active lever presses	0.2	0.3	0.3	-0.5	0.6
Progressive ratio test 2 breakpoint	0.2	0.3	0.3	-0.5	0.5
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.3	-0.0	0.5
Incentive Sensitization - Responses	0.6	0.8	0.9	-0.9	0.8
Incentive Sensitization - Breakpoint	0.6	0.7	0.9	-0.9	0.8
Sum of active levers in priming session hrs 5-6	1.2	1.1	1.3	1.1	-1.0
Progressive ratio	0.2	0.3	0.4	-0.4	0.6
Food seeking constrained by brief footshock	0.8	1.0	1.6	-1.2	0.7
Seeking ratio, punishment vs. effort	0.0	0.1	0.1	-0.3	0.1
Retroperitoneal fat weight	1.0	4.4	5.1	1.9	-2.3
Reaction time number correct	0.8	1.5	1.6	-1.1	1.3
Reaction time mean minus median	2.3	5.6	6.5	2.2	-2.5
Reaction time mean minus median AUC	1.8	4.5	4.9	2.0	-2.2
Reaction time num false alarms	1.7	2.5	3.4	-1.3	1.8
Reaction time num false alarms AUC	1.1	1.7	2.4	-1.0	1.6
Reaction time trials correct on left	0.8	1.5	1.6	-1.1	1.3
Reaction time trials on left	0.7	1.4	1.5	-1.1	1.2
Reaction time mean	0.8	1.2	1.4	1.0	-1.2
Reaction time mean AUC	0.5	0.8	0.9	0.9	-0.9
Median of all reaction times	0.1	0.2	0.3	0.3	-0.5
Reaction time omissions	1.0	1.5	1.6	1.3	-1.2
Reaction time false alarm rate	0.2	0.2	0.4	-0.2	0.6
Reaction time premature initiation rate	0.3	0.4	0.7	-0.8	0.3
Reaction time premature initiations	0.5	0.9	1.2	-1.1	0.7
Std. dev. reaction times	2.3	4.2	4.8	1.9	-2.2
Reaction time trials completed	0.7	1.4	1.5	-1.1	1.2
Reaction time trials AUC	0.5	1.0	1.2	-0.9	1.1
Run reversals in cocaine runway, females	2.1	2.1	3.8	0.7	-2.0
Run reversals in cocaine runway, males	0.0	0.0	0.0	-0.1	-0.1
Latency to leave start box in cocaine runway	0.1	0.1	0.2	-0.0	-0.5
Latency to leave start box in cocaine runway, F	0.0	0.0	0.1	-0.3	-0.1
Latency to leave start box in cocaine runway, M	0.2	0.2	0.4	0.2	-0.6
Std. dev. time between licks in bursts	0.8	1.2	1.2	-1.0	1.1
Total sessions with >9 infusions	0.1	0.1	0.3	0.5	-0.1
Short access day 1 total inactive lever presses	0.1	0.1	0.1	0.4	0.2
Short access day 10 total inactive lever presses	0.5	1.1	1.3	-1.1	0.9
Short access day 1 total infusions	0.7	0.9	1.4	1.2	-0.6
Short access day 10 total infusions	0.1	0.2	0.3	-0.5	0.3
Short access total infusions	0.0	0.0	0.0	-0.0	0.1
Short access day 1 locomotion	0.9	1.1	1.7	1.3	-0.7
Short access day 10 total locomotion	0.3	0.5	0.6	0.6	-0.8
Short access total locomotion	1.2	1.4	1.8	1.3	-1.0
One hour access (0.3 mA shock)	0.3	0.3	0.4	-0.5	0.6
Compulsive drug intake	0.1	0.1	0.2	0.0	0.4
One hour access (shock baseline)	1.2	1.9	2.1	-1.5	1.2
Social response proportion	0.1	0.1	0.1	0.3	-0.2
Social responses	1.0	1.3	1.6	1.3	-1.0
Social time	0.2	0.2	0.3	-0.5	0.5
Soleus weight	0.5	1.4	1.4	1.2	-1.2
Bone: stiffness	2.2	3.6	4.4	2.1	-1.7
Tibialis anterior weight	7.7	26.1	27.3	5.0	-5.2
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.4	0.3	-0.6
Time to tail flick, vehicle, after self-admin	2.2	2.8	3.0	-1.6	1.7
Time to tail flick, test, before self-admin	0.1	0.1	0.1	0.3	0.1
Time to tail flick, test, after self-admin	3.1	3.3	4.1	-2.0	1.5
Delta time to tail flick, vehicle, before/after SA	5.4	5.1	5.4	-2.2	2.3
Delta time to tail flick, test, before/after SA	1.0	1.1	1.7	-1.3	0.7
Tibia length	0.2	0.6	0.6	0.8	-0.8
Ambulatory time before self-admin	5.8	8.7	9.3	3.0	-2.9
Ambulatory time after self-admin	2.7	3.2	3.2	1.7	-1.8
Bone: tissue strength	0.0	0.0	0.0	-0.0	0.1
Total heroin consumption	0.2	0.3	0.5	0.1	-0.7
Bone: trabecular number	1.3	2.1	2.4	-1.4	1.5
Bone: trabecular spacing	0.2	0.3	0.4	0.4	-0.6
Bone: trabecular thickness	1.2	1.5	1.6	-1.3	1.2
Bone: trabecular tissue density	2.6	3.9	3.9	2.0	-2.0
Water consumed over 24 hours	0.7	0.9	0.9	0.9	-1.0
Number of responses in last shaping day	0.5	0.5	0.8	0.9	-0.5