One hour access (0.3 mA shock)

Tags: Behavior · Cocaine

Project: p50_paul_meyer_2020

2 loci · 2 genes with independent associations · 3 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr1	79485178	80785451	1	1	1.74e-13	1.66e-02	8.55e-01	Zfp575
2	chr8	33211184	34601262	2	1	1.21e-19	2.67e-01	2.61e-11	Ddx25

Pleiotropic Associations

Trait	Chi² ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	Corr P	Genes
BMI without tail	5.95	2	0	0	1e+00	Ddx25 Pus3
Body weight	1.37	1	0	0	1e+00	Pus3
Left kidney weight	2.5	1	0	0	1e+00	Zfp575
Right kidney weight	3.4	3	0	0	1e+00	Ddx25 Pus3 Zfp575
Tail length	3.97	3	0	0	1e+00	Ddx25 Pus3 Zfp575
Length without tail	4.72	2	0	0	1e+00	Ddx25 Zfp575
Parametrial fat weight	6.15	1	0	0	1e+00	Pus3
Extensor digitorum longus weight	2.63	1	0	0	1e+00	Pus3
Soleus weight	4.97	1	0	0	1e+00	Pus3
Tibialis anterior weight	2.16	1	0	0	1e+00	Pus3
Patch foraging indifference point 0 sec	4.88	1	0	0	1e+00	Pus3
Patch foraging total patch changes 0 sec	4.98	1	0	0	1e+00	Pus3
Patch foraging water rate 6 sec	4.97	1	0	0	1e+00	Zfp575
Locomotor activity	4.49	1	0	0	1e+00	Ddx25
Locomotor testing distance	4.14	2	0	0	1e+00	Ddx25 Pus3
Reaction time number correct	4.8	1	0	0	1e+00	Zfp575
Reaction time num false alarms AUC	4.41	1	0	0	1e+00	Pus3
Reaction time trials correct on left	4.8	1	0	0	1e+00	Zfp575
Reaction time trials on left	4.9	1	0	0	1e+00	Zfp575
Reaction time mean	4.79	1	0	0	1e+00	Ddx25
Reaction time trials completed	4.9	1	0	0	1e+00	Zfp575
Reaction time trials AUC	4.63	1	0	0	1e+00	Zfp575
Conditioned reinforcement - inactives	10.04	2	0	0	1e+00	Ddx25 Pus3
Conditioned locomotion	5.33	1	0	0	1e+00	Zfp575
Intermittent access intake day 1-15 change	64.62	2	2	100	1e+00	Ddx25 Pus3
Intermittent access intake escalation	34.86	2	2	100	1e+00	Ddx25 Pus3
Intermittent access intake escalation 2	28.93	2	1	50	1e+00	Ddx25 Pus3
Intermitt. access day 1 inactive lever presses	16.8	2	1	50	1e+00	Ddx25 Pus3
Intermitt. access day 15 inactive lever presses	28.37	2	1	50	1e+00	Ddx25 Pus3
Intermitt. access escalation Index	14.59	1	0	0	1e+00	Ddx25
Intermittent access day 15 total infusions	26.55	3	1	50	1e+00	Ddx25 Pus3 Zfp575
Intermittent access terminal intake (last 3 days)	24.48	3	1	50	1e+00	Ddx25 Pus3 Zfp575
Intermittent access total infusions	15.55	3	1	50	1e+00	Ddx25 Pus3 Zfp575
Intermittent access total locomotion	11.21	1	0	0	1e+00	Zfp575
Intermittent access standard deviation	11.66	3	0	0	1e+00	Ddx25 Pus3 Zfp575
Cocaine induced anxiety	9.06	2	0	0	1e+00	Ddx25 Pus3
Baseline Anxiety	5.61	1	0	0	1e+00	Ddx25
Lifetime Intake	22.7	3	1	50	1e+00	Ddx25 Pus3 Zfp575
Incentive Sensitization - Responses	17.36	3	0	0	1e+00	Ddx25 Pus3 Zfp575
Incentive Sensitization - Breakpoint	19.88	3	1	50	1e+00	Ddx25 Pus3 Zfp575
Progressive ratio test 1 active lever presses	8.93	1	0	0	1e+00	Ddx25
Progressive ratio test 1 breakpoint	6.86	1	0	0	1e+00	Ddx25
Progressive ratio test 1 inactive lever presses	9.83	2	0	0	1e+00	Ddx25 Pus3
Progressive ratio test 2 active lever presses	10	3	0	0	1e+00	Ddx25 Pus3 Zfp575
Progressive ratio test 2 breakpoint	12.02	3	0	0	1e+00	Ddx25 Pus3 Zfp575
Progressive ratio test 2 inactive lever presses	19.6	3	1	50	1e+00	Ddx25 Pus3 Zfp575
Total sessions with >9 infusions	11.98	3	0	0	1e+00	Ddx25 Pus3 Zfp575
Short access day 1 total inactive lever presses	26.73	1	1	50	1e+00	Zfp575
Short access day 1 total infusions	34.37	2	1	50	1e+00	Ddx25 Pus3
Short access day 10 total infusions	20.98	2	1	50	1e+00	Ddx25 Pus3
Short access total infusions	37.49	2	1	50	1e+00	Ddx25 Pus3
Short access day 10 total locomotion	9.6	2	0	0	1e+00	Ddx25 Pus3
Compulsive drug intake	14.12	1	0	0	1e+00	Zfp575
One hour access (shock baseline)	27.01	3	2	100	1e+00	Ddx25 Pus3 Zfp575
Number of responses in last shaping day	16.95	3	1	50	1e+00	Ddx25 Pus3 Zfp575
Bone: cortical area	6.36	2	0	0	1e+00	Ddx25 Pus3
Bone: cortical thickness	4.39	1	0	0	1e+00	Ddx25
Bone: cortical thickness	5.77	1	0	0	1e+00	Ddx25
Bone: final force	5.29	1	0	0	1e+00	Ddx25
Bone: final moment	4.65	1	0	0	1e+00	Ddx25
Bone: maximum force	6.75	1	0	0	1e+00	Ddx25
Bone: maximum moment	5.84	1	0	0	1e+00	Ddx25
Bone: minimum diameter	4.04	2	0	0	1e+00	Ddx25 Pus3
Bone: periosteal estimation	3.75	1	0	0	1e+00	Ddx25
Bone: stiffness	4.98	1	0	0	1e+00	Ddx25
Distance traveled before self-admin	13.14	3	0	0	1e+00	Ddx25 Pus3 Zfp575
Distance traveled after self-admin	10.59	2	0	0	1e+00	Ddx25 Zfp575
Delta time in closed arm before/after self-admin	6.42	1	0	0	1e+00	Ddx25
Extinction: sum of active levers before priming	16.06	3	0	0	1e+00	Ddx25 Pus3 Zfp575
Active lever presses in extinction session 6	8.89	3	0	0	1e+00	Ddx25 Pus3 Zfp575
Delta distance traveled before/after self-admin	6.26	2	0	0	1e+00	Ddx25 Pus3
Delta ambulatory time before/after self-admin	11.87	2	0	0	1e+00	Ddx25 Pus3
Time in open arm before self-admin	21.1	1	0	0	1e+00	Zfp575
Time to tail flick, vehicle, before self-admin	9.26	1	0	0	1e+00	Ddx25
Time to tail flick, vehicle, after self-admin	9	1	0	0	1e+00	Zfp575
Time to tail flick, test, before self-admin	8.19	2	0	0	1e+00	Ddx25 Zfp575
Ambulatory time before self-admin	16.41	3	1	50	1e+00	Ddx25 Pus3 Zfp575
Ambulatory time after self-admin	5.96	2	0	0	1e+00	Ddx25 Zfp575
Total heroin consumption	10.44	2	0	0	1e+00	Ddx25 Pus3
Vertical activity count, locomotor time 1	13.25	1	0	0	1e+00	Zfp575
Weight adjusted by age	15.78	1	0	0	1e+00	Zfp575
Seeking ratio, delayed vs. immediate footshock	10.88	1	0	0	1e+00	Zfp575
Locomotion in novel chamber	6.51	1	0	0	1e+00	Zfp575
Food seeking constrained by brief footshock	11.04	1	0	0	1e+00	Zfp575
Run reversals in cocaine runway, males	7.73	2	0	0	1e+00	Ddx25 Pus3
Latency to leave start box in cocaine runway	5.91	1	0	0	1e+00	Ddx25
Latency to leave start box in cocaine runway, M	12.02	3	0	0	1e+00	Ddx25 Pus3 Zfp575
Fe content in liver	8.46	1	0	0	1e+00	Pus3
Sr content in liver	9.74	1	0	0	1e+00	Ddx25

Associations by panel

Tissue	RNA modality	# hits	Avg chisq
Adipose	alternative polyA	0	1.13
Adipose	alternative TSS	0	1.07
Adipose	gene expression	1	1.14
Adipose	isoform ratio	0	1.14
Adipose	intron excision ratio	0	1.11
Adipose	mRNA stability	1	1.17
BLA	alternative polyA	0	1.17
BLA	alternative TSS	0	1.21
BLA	gene expression	0	1.17
BLA	isoform ratio	0	1.18
BLA	intron excision ratio	0	1.17
BLA	mRNA stability	0	1.18
Brain	alternative polyA	0	1.18
Brain	alternative TSS	0	1.12
Brain	gene expression	0	1.17
Brain	isoform ratio	0	1.2
Brain	intron excision ratio	0	1.14
Brain	mRNA stability	0	1.2
Eye	alternative polyA	0	1.37
Eye	alternative TSS	0	1.03
Eye	gene expression	0	1.14
Eye	isoform ratio	0	1.23
Eye	intron excision ratio	0	1.18
Eye	mRNA stability	0	1.2
IL	alternative polyA	0	1.25
IL	alternative TSS	0	1.07
IL	gene expression	0	1.16
IL	isoform ratio	0	1.22
IL	intron excision ratio	0	1.35
IL	mRNA stability	0	1.29
LHb	alternative polyA	0	1.2
LHb	alternative TSS	0	1.52
LHb	gene expression	0	1.21
LHb	isoform ratio	0	1.32
LHb	intron excision ratio	0	1.22
LHb	mRNA stability	0	1.18
Liver	alternative polyA	0	1.22
Liver	alternative TSS	0	1.18
Liver	gene expression	0	1.15
Liver	isoform ratio	0	1.18
Liver	intron excision ratio	0	1.12
Liver	mRNA stability	0	1.12
NAcc	alternative polyA	0	1.2
NAcc	alternative TSS	0	1.12
NAcc	gene expression	0	1.18
NAcc	isoform ratio	0	1.15
NAcc	intron excision ratio	0	1.15
NAcc	mRNA stability	0	1.19
OFC	alternative polyA	0	1.3
OFC	alternative TSS	0	1.13
OFC	gene expression	0	1.15
OFC	isoform ratio	0	1.24
OFC	intron excision ratio	0	1.35
OFC	mRNA stability	0	1.2
PL	alternative polyA	0	1.17
PL	alternative TSS	0	1.1
PL	gene expression	0	1.16
PL	isoform ratio	0	1.22
PL	intron excision ratio	0	1.19
PL	mRNA stability	1	1.24
pVTA	alternative polyA	0	1.16
pVTA	alternative TSS	0	1.1
pVTA	gene expression	0	1.18
pVTA	isoform ratio	0	1.22
pVTA	intron excision ratio	0	1.21
pVTA	mRNA stability	0	1.26
RMTg	alternative polyA	0	1.2
RMTg	alternative TSS	0	1.02
RMTg	gene expression	0	1.14
RMTg	isoform ratio	0	1.09
RMTg	intron excision ratio	0	1.3
RMTg	mRNA stability	0	1.33