Hub : Traits

One hour access (0.3 mA shock)

Tags: Behavior · Cocaine

Project: p50_paul_meyer_2020

3 significantly associated models · 2 unique genes

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 8 33171536 34259593 1 1 1.5e-07 0.203 0.5 72 Foxred1
2 11 39057816 40174684 1 1 5.5e-11 0.012 1.0 100 Epha6

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
BMI without tail 4.4 1 0 0 0 1 Foxred1
Heart weight 4.4 1 0 0 0 1 Epha6
Right kidney weight 2.3 1 0 0 0 1 Foxred1
Length without tail 4.1 1 0 0 0 1 Foxred1
Parametrial fat weight 12.3 2 1 50 0 1 Epha6 Foxred1
Intraocular pressure 5.2 1 0 0 0 1 Epha6
Tibia length 2.4 1 0 0 0 1 Epha6
Food consumed during 24 hour testing period 5.4 1 0 0 0 1 Epha6
Times rat made contact with spout 14.7 1 0 0 0 1 Epha6
Water consumed over 24 hours 15.6 1 0 0 0 1 Epha6
Delay discounting total patch changes 12 sec 11.7 1 0 0 0 1 Epha6
Delay discounting total patch changes 18 sec 13.1 1 0 0 0 1 Epha6
Delay discounting total patch changes 6 sec 11.6 1 0 0 0 1 Epha6
Delay discounting water rate 18 sec 10.7 1 0 0 0 1 Epha6
Locomotor activity 6.9 1 0 0 0 1 Epha6
Locomotor testing distance 8.0 1 0 0 0 1 Epha6
Reaction time num false alarms AUC 5.3 1 0 0 0 1 Foxred1
Reaction time premature initiation rate 8.8 1 0 0 0 1 Epha6
Reaction time premature initiations 5.0 1 0 0 0 1 Epha6
Conditioned locomotion 14.7 1 0 0 0 1 Epha6
Cocaine response before conditioning 6.7 1 0 0 0 1 Epha6
Condit. Reinf. lever presses 6.0 1 0 0 0 1 Epha6
Pavlov. Cond. lever latency 5.2 1 0 0 0 1 Epha6
Pavlov. Cond. lever contacts 5.6 1 0 0 0 1 Epha6
Pavlov. Cond. magazine entry number 6.5 1 0 0 0 1 Epha6
Pavlov. Cond. response bias 4.5 1 0 0 0 1 Epha6
Conditioned reinforcement - actives 21.1 1 0 0 0 1 Epha6
Conditioned reinforcement - inactives 20.6 2 1 50 0 1 Epha6 Foxred1
Intermittent access intake day 1-15 change 21.8 1 0 0 0 1 Foxred1
Intermittent access intake escalation 10.6 1 0 0 0 1 Foxred1
Intermittent access intake escalation 2 14.3 1 0 0 0 1 Foxred1
Intermitt. access day 1 inactive lever presses 11.3 1 0 0 0 1 Foxred1
Intermittent access day 1 total infusions 10.6 1 0 0 0 1 Epha6
Intermittent access day 15 total infusions 11.4 2 0 0 0 1 Epha6 Foxred1
Intermittent access terminal intake (last 3 days) 15.3 2 0 0 0 1 Epha6 Foxred1
Intermittent access total infusions 17.6 1 0 0 0 1 Epha6
Cocaine induced anxiety 15.4 1 0 0 0 1 Epha6
Post-drug Anxiety 5.9 1 0 0 0 1 Epha6
Baseline Anxiety 18.8 1 0 0 0 1 Epha6
Lifetime Intake 24.0 2 1 50 0 1 Epha6 Foxred1
Incentive Sensitization - Responses 8.2 2 0 0 0 1 Epha6 Foxred1
Incentive Sensitization - Breakpoint 7.8 2 0 0 0 1 Epha6 Foxred1
Progressive ratio test 1 active lever presses 25.4 1 1 50 0 1 Epha6
Progressive ratio test 1 breakpoint 30.1 1 1 50 0 1 Epha6
Progressive ratio test 1 inactive lever presses 9.2 1 0 0 0 1 Epha6
Progressive ratio test 2 active lever presses 31.2 1 1 50 0 1 Epha6
Progressive ratio test 2 breakpoint 24.1 1 1 50 0 1 Epha6
Progressive ratio test 2 inactive lever presses 22.1 2 1 50 0 1 Epha6 Foxred1
Total sessions with >9 infusions 13.0 2 0 0 0 1 Epha6 Foxred1
Short access day 1 total inactive lever presses 6.6 1 0 0 0 1 Epha6
Short access day 1 total infusions 26.8 2 1 50 0 1 Epha6 Foxred1
Short access day 10 total infusions 7.1 1 0 0 0 1 Foxred1
Short access total infusions 29.4 2 1 50 0 1 Epha6 Foxred1
One hour access (shock baseline) 18.6 2 0 0 0 1 Epha6 Foxred1
Locomotion distance, session 1 10.1 1 0 0 0 1 Epha6
Stereotopy head waving bouts, day 3 7.0 1 0 0 0 1 Epha6
Locomotion velocity, session 7 6.8 1 0 0 0 1 Epha6
Locomotion distance, session 7 12.3 1 0 0 0 1 Epha6
Locomotion distance, session 8 5.0 1 0 0 0 1 Epha6
Degree of sensitization distance 6.1 1 0 0 0 1 Epha6
Condit. Reinf. active minus inactive responses 9.4 1 0 0 0 1 Epha6
Condit. Reinf. active-inactive response ratio 8.4 1 0 0 0 1 Epha6
Condit. Reinf. active responses 7.5 1 0 0 0 1 Epha6
Incentive salience index mean 7.9 1 0 0 0 1 Epha6
Condit. Reinf. lever presses 8.2 1 0 0 0 1 Epha6
Time in familiar zone, hab. session 1 9.3 1 0 0 0 1 Epha6
Time in novel zone, hab. session 1 6.4 1 0 0 0 1 Epha6
Total zone transitions, hab. session 1 8.1 1 0 0 0 1 Epha6
Total locomotion distance, hab. session 1 4.8 1 0 0 0 1 Epha6
Locomotion velocity, hab. session 1 6.1 1 0 0 0 1 Epha6
Time in familiar zone, hab. session 2 29.9 1 1 50 0 1 Epha6
Time in novel zone, hab. session 2 25.2 1 1 50 0 1 Epha6
Total zone transitions, hab. session 2 6.1 1 0 0 0 1 Epha6
Total locomotion distance, hab. session 2 8.2 1 0 0 0 1 Epha6
Locomotion velocity, hab. session 2 8.1 1 0 0 0 1 Epha6
Novelty place preference 5.8 1 0 0 0 1 Epha6
Pavlov. Cond. lever latency 14.6 1 0 0 0 1 Epha6
Pavlov. Cond. magazine entry latency 31.4 1 1 50 0 1 Epha6
Pavlov. Cond. change in total contacts 7.3 1 0 0 0 1 Epha6
Pavlov. Cond. index score 24.3 1 1 50 0 1 Epha6
Pavlov. Cond. latency score 22.4 1 1 50 0 1 Epha6
Pavlov. Cond. lever contacts 20.5 1 1 50 0 1 Epha6
Pavlov. Cond. magazine entry number 12.8 1 0 0 0 1 Epha6
Pavlov. Cond. lever-magazine prob. diff. 22.9 1 1 50 0 1 Epha6
Pavlov. Cond. response bias 24.6 1 1 50 0 1 Epha6
Bone surface 4.2 1 0 0 0 1 Epha6
Bone: connectivity density 4.6 1 0 0 0 1 Epha6
Bone: cortical area 4.5 1 0 0 0 1 Foxred1
Bone: cortical porosity 5.6 1 0 0 0 1 Epha6
Bone: cortical thickness 13.4 1 0 0 0 1 Epha6
Bone: endosteal estimation 3.3 1 0 0 0 1 Epha6
Bone: marrow area 3.0 1 0 0 0 1 Epha6
Bone: maximum diameter 6.1 1 0 0 0 1 Epha6
Bone: maximum force 5.0 1 0 0 0 1 Foxred1
Bone: maximum moment 5.4 1 0 0 0 1 Foxred1
Bone: periosteal estimation 3.0 1 0 0 0 1 Epha6
Bone: periosteal perimeter 4.9 1 0 0 0 1 Epha6
Bone: stiffness 7.0 1 0 0 0 1 Epha6
Time to tail flick, vehicle, after self-admin 5.9 1 0 0 0 1 Foxred1
Time to tail flick, test, before self-admin 6.5 1 0 0 0 1 Epha6
Delta time to tail flick, vehicle, before/after SA 7.7 2 0 0 0 1 Epha6 Foxred1
Total heroin consumption 5.1 1 0 0 0 1 Epha6
Area under the delay curve 6.5 1 0 0 0 1 Epha6
Delay disc. indifference point, 0s delay 11.0 2 0 0 0 1 Epha6 Foxred1
Delay disc. indifference point, 4s delay 9.7 1 0 0 0 1 Epha6
Delay disc. indifference point, 8s delay 7.9 1 0 0 0 1 Epha6
Delay discount exponential model param 6.6 1 0 0 0 1 Epha6
Delay discount hyperbolic model param 6.7 1 0 0 0 1 Epha6
Time >=10cm from walls, locomotor time 1 6.0 1 0 0 0 1 Epha6
Bouts of movement, locomotor time 1 7.9 1 0 0 0 1 Epha6
Vertical activity count, locomotor time 1 7.2 1 0 0 0 1 Epha6
Rest time, locomotor task time 2 5.7 1 0 0 0 1 Epha6
Seeking ratio, delayed vs. immediate footshock 11.1 1 0 0 0 1 Epha6
Locomotion in novel chamber post-restriction 15.3 1 0 0 0 1 Epha6
Latency to leave start box in cocaine runway 8.5 1 0 0 0 1 Epha6
Co content in liver 10.4 1 0 0 0 1 Foxred1
Na content in liver 10.2 1 0 0 0 1 Epha6
Se content in liver 11.1 1 0 0 0 1 Epha6

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 0 0.000 1.2
Adipose alternative TSS 0 0.000 1.2
Adipose gene expression 0 0.000 1.2
Adipose isoform ratio 0 0.000 1.2
Adipose intron excision ratio 0 0.000 1.1
Adipose mRNA stability 0 0.000 1.1
BLA alternative polyA 0 0.000 1.2
BLA alternative TSS 0 0.000 1.1
BLA gene expression 0 0.000 1.2
BLA isoform ratio 0 0.000 1.1
BLA intron excision ratio 0 0.000 1.2
BLA mRNA stability 0 0.000 1.1
Brain alternative polyA 0 0.000 1.1
Brain alternative TSS 0 0.000 1.1
Brain gene expression 0 0.000 1.2
Brain isoform ratio 0 0.000 1.2
Brain intron excision ratio 0 0.000 1.1
Brain mRNA stability 0 0.000 1.2
Eye alternative polyA 0 0.000 1.3
Eye alternative TSS 0 0.000 1.2
Eye gene expression 0 0.000 1.1
Eye isoform ratio 0 0.000 1.2
Eye intron excision ratio 0 0.000 1.1
Eye mRNA stability 0 0.000 1.3
IL alternative polyA 0 0.000 1.4
IL alternative TSS 0 0.000 1.2
IL gene expression 0 0.000 1.2
IL isoform ratio 0 0.000 1.3
IL intron excision ratio 0 0.000 1.3
IL mRNA stability 0 0.000 1.2
LHb alternative polyA 0 0.000 1.2
LHb alternative TSS 0 0.000 1.3
LHb gene expression 0 0.000 1.2
LHb isoform ratio 0 0.000 1.2
LHb intron excision ratio 0 0.000 1.3
LHb mRNA stability 0 0.000 1.2
Liver alternative polyA 0 0.000 1.1
Liver alternative TSS 0 0.000 1.0
Liver gene expression 0 0.000 1.2
Liver isoform ratio 1 0.042 1.2
Liver intron excision ratio 0 0.000 1.1
Liver mRNA stability 0 0.000 1.2
NAcc alternative polyA 0 0.000 1.1
NAcc alternative TSS 0 0.000 1.2
NAcc gene expression 0 0.000 1.2
NAcc isoform ratio 0 0.000 1.2
NAcc intron excision ratio 0 0.000 1.2
NAcc mRNA stability 0 0.000 1.2
OFC alternative polyA 0 0.000 1.2
OFC alternative TSS 0 0.000 1.2
OFC gene expression 0 0.000 1.2
OFC isoform ratio 0 0.000 1.3
OFC intron excision ratio 0 0.000 1.3
OFC mRNA stability 0 0.000 1.2
PL alternative polyA 0 0.000 1.1
PL alternative TSS 2 0.170 1.2
PL gene expression 0 0.000 1.2
PL isoform ratio 0 0.000 1.2
PL intron excision ratio 0 0.000 1.1
PL mRNA stability 0 0.000 1.2

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.