Hub : Genes

Snx15

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Snx15 0.04 0.03 8.6e-05 0.04 0.04 0.04 0.04 6.2e-05 5.5e-05 9.3e-05 8.1e-05
2 NAcc gene expression Snx15 0.1 0.05 0.0e+00 0.13 0.13 0.13 0.13 1.5e-18 2.0e-19 2.4e-19 3.4e-19
3 BLA gene expression Snx15 0.1 0.06 7.4e-05 0.02 0.05 0.06 0.05 4.2e-02 1.8e-03 2.5e-04 9.9e-04
4 Brain gene expression Snx15 0.2 0.08 2.8e-14 0.13 0.15 0.13 0.13 6.0e-12 4.2e-14 7.0e-12 6.4e-12
5 pVTA gene expression Snx15 0.39 0.14 0.0e+00 0.21 0.23 0.23 0.23 1.3e-16 2.0e-18 3.6e-18 4.7e-18
6 BLA mRNA stability Snx15 0.07 0.05 8.5e-03 0.03 0.02 0.01 0.03 1.8e-02 2.6e-02 7.8e-02 1.5e-02
7 Brain mRNA stability Snx15 0.54 0.14 0.0e+00 0.24 0.25 0.24 0.23 7.0e-22 6.0e-23 8.2e-22 1.1e-21
8 Adipose mRNA stability Snx15 0.06 0.04 1.7e-04 0.02 0.02 0.01 0.01 4.6e-03 5.2e-03 2.5e-02 1.7e-02
9 LHb gene expression Snx15 0.68 0.16 2.3e-03 0.08 0.04 0.06 0.07 5.7e-03 4.1e-02 1.8e-02 8.5e-03
10 NAcc mRNA stability Snx15 0.08 0.04 8.6e-09 0.04 0.04 0.04 0.04 3.5e-06 4.1e-07 4.4e-07 2.9e-06
11 OFC mRNA stability Snx15 0.32 0.15 2.7e-04 0.07 0.1 0.19 0.07 1.1e-02 2.5e-03 3.3e-05 1.2e-02
12 pVTA mRNA stability Snx15 0.05 0.03 7.9e-03 0.02 0.01 0.03 0.03 1.0e-02 2.0e-02 1.3e-03 9.5e-04
13 PL mRNA stability Snx15 0.05 0.03 9.8e-04 0.01 0.02 0.02 0.01 3.0e-02 3.2e-03 3.5e-03 1.2e-02
14 RMTg mRNA stability Snx15 0.18 0.1 1.8e-03 0.05 0.08 0.09 0.1 1.7e-02 4.4e-03 2.5e-03 1.7e-03
15 LHb mRNA stability Snx15 0.48 0.22 1.3e-03 0.12 0.05 0.1 0.16 1.0e-03 2.8e-02 2.6e-03 1.5e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density1.32.23.9-1.4-1.4-1.9-1.9-1.71.00.91.0-2.01.31.51.61.31.31.3
Area under the delay curve0.20.31.2-0.3-0.3-0.7-0.30.20.6-0.10.40.10.10.41.10.70.50.6
BMI with tail3.813.025.4-3.7-3.7-4.8-4.7-4.32.32.02.5-5.02.73.14.33.13.13.0
BMI without tail1.03.29.3-2.4-2.2-3.1-2.4-1.70.60.40.8-2.20.71.11.91.51.71.6
Body weight1.77.619.6-4.3-4.3-4.4-4.1-3.70.10.00.1-4.10.60.92.60.60.40.4
Weight adjusted by age0.60.91.8-1.3-1.3-0.9-1.0-1.1-1.1-1.0-1.1-0.6-0.3-0.5-0.4-0.9-0.8-0.9
Bone surface3.15.715.7-3.4-3.5-3.3-3.8-4.00.50.10.4-3.41.61.61.90.50.50.6
Bone volume2.24.09.7-2.1-2.2-2.4-2.9-3.11.10.71.0-2.82.02.01.91.11.21.3
Breakpoint value in progressive ratio session1.31.54.6-2.1-2.1-1.9-1.9-1.7-0.9-1.2-0.6-1.10.10.10.0-0.5-0.2-0.1
Number of licking bursts0.10.20.4-0.6-0.6-0.5-0.6-0.6-0.4-0.4-0.2-0.50.20.3-0.2-0.10.10.1
Context. condit. distance diff. score0.70.92.11.41.40.81.21.20.90.90.90.70.10.30.60.90.70.8
Locomotion velocity, session 10.20.30.9-0.00.00.10.50.6-0.1-0.2-0.40.3-1.0-0.90.2-0.5-0.8-0.7
Locomotion distance, session 10.70.92.6-1.2-1.1-1.6-1.2-0.80.30.40.4-1.20.20.61.20.80.80.7
Locomotion velocity, session 21.41.64.9-2.2-2.1-2.2-2.0-1.7-0.5-0.3-0.2-1.70.10.50.60.10.30.3
Locomotion distance, session 20.50.72.5-1.4-1.2-1.6-1.1-0.6-0.3-0.1-0.2-0.9-0.10.40.50.50.60.5
Locomotion velocity, session 31.31.55.0-0.10.0-0.6-0.5-0.51.81.81.5-1.30.81.22.21.50.91.0
Locomotion distance, session 30.00.00.30.10.1-0.00.10.10.30.30.3-0.1-0.00.10.60.20.00.1
Stereotopy head waving bouts, day 31.31.65.10.20.4-0.3-0.2-0.22.02.01.6-1.20.71.12.21.61.00.9
Stereotopy head waving duration, day 30.70.92.10.50.60.10.0-0.11.41.41.2-0.70.81.01.21.21.00.9
Locomotion velocity, session 71.82.04.0-0.00.1-0.7-0.7-0.51.51.51.6-1.21.41.91.81.91.92.0
Locomotion distance, session 70.20.31.1-0.3-0.1-0.6-0.30.20.40.60.5-0.50.00.51.00.90.50.6
Stereotopy head waving bouts, day 70.80.91.9-0.1-0.2-0.4-0.8-1.00.90.70.8-1.01.41.40.90.91.21.2
Stereotopy head waving duration, day 70.91.02.4-1.1-1.2-1.2-1.5-1.50.1-0.10.2-1.31.11.10.40.61.01.0
Locomotion velocity, session 80.60.71.8-0.9-0.9-0.6-0.2-0.0-0.7-0.6-0.8-0.1-1.3-1.1-0.1-1.0-1.4-1.3
Locomotion distance, session 80.81.12.70.10.1-0.5-0.4-0.41.31.51.3-1.00.81.21.61.41.21.2
Degree of sensitization distance0.60.61.5-0.4-0.3-0.7-0.6-0.50.91.00.9-1.00.50.81.21.00.70.6
Degree of sensitization stereotypy0.70.81.9-0.8-0.8-0.8-1.3-1.40.3-0.10.2-1.11.21.00.40.40.90.9
Conditioned locomotion0.60.72.0-1.4-1.4-1.1-1.0-0.9-0.6-0.5-0.7-0.9-0.5-0.4-0.1-0.6-0.7-0.7
Cocaine response after cond. corrected0.60.71.61.21.30.91.21.30.81.00.60.4-0.4-0.20.50.6-0.10.0
Cocaine response after cond. not corrected0.40.51.11.01.00.80.90.90.91.00.70.2-0.3-0.10.70.6-0.00.0
Cocaine response before conditioning0.30.41.1-0.8-0.9-0.7-0.9-1.0-0.5-0.6-0.3-0.60.40.3-0.2-0.30.10.1
Saline control response1.72.26.0-2.4-2.5-1.9-1.6-1.3-1.6-1.3-1.5-1.1-1.1-1.0-0.3-1.1-1.1-1.2
Bone: connectivity density1.92.97.2-2.4-2.5-2.7-2.7-2.50.20.20.4-2.41.01.11.30.70.80.8
Bone: cortical apparent density0.70.92.3-0.00.00.20.50.8-1.3-1.5-1.31.2-0.8-1.0-1.5-1.0-0.5-0.5
Bone: cortical area0.30.51.9-1.0-1.1-0.8-1.1-1.40.20.10.0-1.00.40.50.4-0.2-0.4-0.3
Bone: cortical porosity0.20.20.4-0.6-0.6-0.7-0.6-0.5-0.1-0.1-0.0-0.50.20.20.20.20.40.3
Bone: cortical porosity0.30.41.1-1.0-1.0-1.1-0.9-0.7-0.3-0.2-0.2-0.80.10.10.30.10.20.2
Bone: cortical thickness2.03.35.8-1.7-1.8-1.0-0.5-0.2-2.3-2.3-2.40.5-2.0-2.0-1.7-2.3-2.2-2.1
Bone: cortical thickness1.31.63.7-0.4-0.4-0.10.61.1-1.1-1.4-1.51.1-1.9-1.8-0.6-1.4-1.7-1.5
Bone: cortical tissue density0.81.12.9-0.1-0.10.20.40.8-1.5-1.7-1.51.3-0.9-1.2-1.6-1.1-0.6-0.6
Condit. Reinf. active minus inactive responses0.10.10.5-0.5-0.5-0.7-0.4-0.1-0.3-0.4-0.3-0.0-0.00.2-0.00.20.40.3
Condit. Reinf. active-inactive response ratio0.20.20.9-0.1-0.1-0.10.10.5-0.7-1.0-0.70.7-0.3-0.3-0.8-0.30.00.1
Condit. Reinf. active responses0.30.40.9-0.4-0.3-0.7-0.7-0.60.30.50.6-0.60.71.00.50.80.90.8
Condit. Reinf. inactive responses1.21.52.9-0.1-0.1-0.5-0.8-1.11.31.71.6-1.41.41.61.51.41.21.1
Incentive salience index mean0.50.61.7-0.9-0.9-1.3-1.0-0.70.10.20.3-0.80.40.80.60.70.80.8
Condit. Reinf. lever presses0.91.32.6-1.1-1.1-1.4-1.5-1.60.50.80.7-1.61.01.21.10.80.80.8
Condit. Reinf. active minus inactive responses0.30.41.10.20.20.2-0.3-0.60.80.50.6-0.41.01.00.60.50.70.8
Condit. Reinf. active-inactive response ratio1.82.14.20.60.60.4-0.5-1.22.01.91.9-1.22.02.11.71.41.31.3
Condit. Reinf. active responses0.20.20.6-0.4-0.4-0.4-0.7-0.60.0-0.3-0.0-0.40.60.60.00.20.70.7
Condit. Reinf. inactive responses0.50.62.0-0.9-0.8-0.9-0.40.3-1.2-1.4-1.20.3-0.7-0.7-0.9-0.40.00.1
Condit. Reinf. lever presses1.01.44.6-1.7-1.7-1.4-2.0-2.2-0.1-0.3-0.2-1.61.00.90.7-0.10.20.4
Condit. Reinf. lever reinforcers received0.20.30.7-0.7-0.7-0.5-0.8-0.8-0.3-0.7-0.4-0.40.50.4-0.2-0.10.40.5
Conditioned reinforcement - actives0.20.42.00.30.10.5-0.5-1.40.70.60.4-0.61.20.90.3-0.1-0.2-0.3
Conditioned reinforcement - inactives1.11.75.22.32.12.01.20.31.51.31.20.71.51.00.10.70.60.5
Conditioned locomotion3.14.113.23.63.63.42.61.71.61.61.31.91.20.7-0.40.80.70.5
Patch foraging indifference point 0 sec0.00.00.10.10.10.1-0.00.10.40.10.00.00.20.20.20.20.10.1
Patch foraging indifference point AUC0.91.32.7-1.5-1.7-1.1-1.3-1.4-1.6-1.4-1.5-0.4-0.0-0.6-0.8-1.1-0.7-0.5
Delay disc. indifference point, 0s delay0.60.72.9-0.1-0.1-0.8-0.30.11.20.70.6-0.10.30.81.71.21.01.0
Delay disc. indifference point, 16s delay0.40.50.90.70.70.20.20.30.80.30.90.30.80.90.31.00.90.9
Delay disc. indifference point, 2s delay0.50.51.70.1-0.0-0.3-0.3-0.41.20.81.1-0.40.70.91.30.80.70.6
Delay disc. indifference point, 24s delay0.40.41.00.20.30.20.71.0-0.6-0.6-0.21.0-0.9-0.8-0.4-0.5-0.8-0.9
Delay disc. indifference point, 4s delay0.10.20.8-0.1-0.1-0.60.00.50.10.20.20.4-0.3-0.00.90.60.30.3
Delay disc. indifference point, 8s delay0.10.10.5-0.2-0.1-0.50.10.60.5-0.2-0.00.2-0.4-0.20.70.30.10.1
Indifference point function ln k2.74.711.53.33.42.63.03.02.52.22.11.7-0.20.41.11.50.70.6
Indifference point function log k2.74.711.53.33.42.63.03.02.52.22.11.7-0.20.41.11.50.70.6
Patch foraging total patch changes 0 sec0.10.10.30.10.20.30.40.5-0.1-0.2-0.40.4-0.5-0.4-0.2-0.3-0.5-0.5
Patch foraging total patch changes 12 sec1.82.46.4-2.5-2.5-2.3-2.0-1.6-1.6-1.7-1.7-1.0-0.3-0.6-0.4-0.9-0.4-0.3
Patch foraging total patch changes 18 sec0.30.51.4-1.0-1.1-1.1-1.2-1.2-0.5-0.2-0.3-0.70.50.40.10.10.30.3
Patch foraging total patch changes 24 sec0.81.42.6-1.4-1.5-0.8-0.8-0.8-1.6-1.3-1.6-0.1-0.8-1.0-0.8-1.4-1.3-1.2
Patch foraging total patch changes 6 sec0.40.61.8-1.3-1.3-1.2-0.9-0.6-0.6-0.5-0.7-0.4-0.5-0.40.2-0.3-0.5-0.4
Patch foraging time to switch 0 sec2.14.28.6-2.3-2.3-2.8-2.9-2.80.80.50.9-2.91.81.91.81.41.81.7
Patch foraging water rate 0 sec2.34.913.83.33.33.73.53.00.50.50.32.9-1.2-1.1-1.1-0.8-1.4-1.3
Patch foraging water rate 12 sec4.28.722.74.34.44.64.84.40.60.90.43.8-1.9-1.7-1.4-0.7-1.5-1.6
Patch foraging water rate 18 sec1.52.36.12.22.32.32.52.30.81.10.71.6-1.0-0.8-0.00.0-0.7-0.8
Patch foraging water rate 24 sec2.43.38.92.82.83.02.92.51.01.10.62.0-1.0-0.7-0.1-0.2-0.9-0.9
Patch foraging water rate 6 sec3.34.712.23.03.03.23.53.30.50.90.42.7-1.8-1.5-0.7-0.6-1.5-1.6
Seeking ratio, delayed vs. immediate footshock0.20.21.10.10.2-0.1-0.10.40.3-0.10.3-0.20.40.5-0.10.81.01.1
Distance traveled before self-admin0.81.02.7-1.1-1.1-1.2-1.5-1.60.0-0.00.5-1.21.21.10.40.50.80.8
Distance traveled after self-admin0.30.31.4-0.4-0.4-0.2-0.3-0.2-1.2-0.9-0.60.40.0-0.2-1.2-0.5-0.10.1
Extensor digitorum longus weight3.112.236.6-6.0-6.1-5.4-4.9-4.3-2.4-2.4-2.4-3.8-0.7-0.60.7-1.4-1.1-1.1
Bone: elastic displacement2.02.34.61.41.41.72.12.1-0.6-0.3-0.71.8-1.8-1.8-1.1-1.1-1.5-1.6
Bone: elastic work1.01.33.5-0.8-0.8-0.50.20.6-1.2-1.1-1.30.4-1.9-1.8-0.5-1.3-1.6-1.6
Bone: endosteal estimation2.65.812.80.40.4-0.5-1.0-1.53.43.43.3-2.32.52.93.62.82.12.0
Bone: endosteal perimeter3.47.215.10.70.6-0.1-1.1-1.93.93.63.6-2.53.13.43.73.02.42.3
Epididymis fat weight1.86.212.83.33.12.61.50.33.63.63.4-0.12.42.42.02.21.71.6
Delta time in closed arm before/after self-admin0.60.52.3-0.5-0.4-0.40.40.8-0.6-0.2-0.60.3-1.5-1.30.2-0.4-0.9-0.9
Delta time in open arm before/after self-admin0.20.21.1-0.2-0.4-0.1-0.7-1.1-0.4-0.4-0.1-0.20.90.6-0.4-0.20.10.2
Diff in mean of infusions in LGA sessions0.30.40.7-0.7-0.8-0.5-0.4-0.3-0.7-0.7-0.8-0.3-0.6-0.6-0.1-0.7-0.7-0.6
Delay discount exponential model param0.10.20.80.30.30.70.2-0.2-0.40.2-0.2-0.20.0-0.2-0.9-0.5-0.3-0.4
Extinction: sum of active levers before priming1.61.74.7-2.0-2.0-2.2-2.0-1.7-1.3-0.6-0.8-1.50.50.5-0.00.30.60.6
Active lever presses in extinction session 61.61.65.7-1.9-2.0-1.6-2.0-2.4-1.0-0.2-0.3-1.60.50.4-0.1-0.5-0.3-0.5
Bone: final force1.22.05.2-2.2-2.3-2.0-2.2-2.20.1-0.1-0.1-1.90.30.51.1-0.2-0.3-0.3
Bone: final moment1.11.84.8-2.1-2.2-2.0-2.1-2.10.1-0.1-0.1-1.80.30.41.1-0.2-0.3-0.3
Food consumed during 24 hour testing period0.30.41.20.20.20.80.30.0-0.6-0.8-0.70.5-0.2-0.3-1.1-1.0-0.7-0.6
Glucose2.13.36.81.31.40.30.30.32.52.62.6-0.91.61.82.12.62.22.1
Heart weight1.62.56.20.30.3-0.9-0.30.01.92.52.1-1.40.91.42.22.51.91.8
Delay discount hyperbolic model param0.20.21.20.30.30.70.3-0.1-0.50.0-0.4-0.0-0.1-0.4-1.1-0.6-0.5-0.5
Intermittent access intake day 1-15 change0.40.82.71.61.51.60.90.20.60.70.50.70.90.5-0.30.20.20.1
Intermittent access intake escalation0.30.72.41.51.41.60.80.00.50.70.40.70.90.5-0.30.00.10.0
Intermittent access intake escalation 20.50.62.31.41.31.50.80.10.40.50.40.70.80.4-0.30.00.10.1
Intermitt. access day 1 inactive lever presses0.10.20.60.50.50.40.50.5-0.1-0.5-0.10.60.0-0.6-0.8-0.10.10.1
Intermitt. access day 15 inactive lever presses0.71.52.91.61.51.10.5-0.11.61.51.4-0.21.71.20.51.21.41.3
Intermitt. access escalation Index1.11.63.51.81.91.41.41.61.21.01.41.20.40.80.11.11.21.1
Intermittent access day 1 total infusions3.86.213.91.21.20.2-0.5-1.13.73.43.3-1.52.93.02.93.02.82.6
Intermittent access day 15 total infusions3.34.910.12.72.52.00.8-0.33.23.12.8-0.12.72.31.72.11.91.7
Intermittent access terminal intake (last 3 days)4.66.013.82.32.11.50.2-1.03.73.63.3-0.83.22.92.52.52.22.0
Intermittent access total infusions4.85.712.71.81.60.9-0.1-1.13.63.53.3-1.13.02.82.72.72.32.1
Intermittent access day 1 locomotion2.53.26.61.21.10.3-0.2-0.62.62.52.3-0.82.22.01.92.32.12.0
Intermittent access day 15 total locomotion2.44.48.82.42.11.60.4-0.72.92.72.6-0.33.02.51.72.12.11.9
Intermittent access total locomotion6.98.317.42.52.31.40.1-1.14.23.93.8-0.93.83.52.73.23.02.8
Intermittent access standard deviation0.40.82.71.71.61.61.10.50.61.00.30.60.6-0.0-0.20.20.0-0.1
Left kidney weight0.62.65.21.31.20.40.2-0.22.32.12.1-0.41.72.01.81.91.81.9
Right kidney weight0.20.92.61.21.11.00.60.01.61.41.10.10.80.81.20.70.50.5
Cocaine induced anxiety0.10.10.3-0.1-0.2-0.2-0.4-0.6-0.2-0.10.1-0.30.50.3-0.00.00.30.3
Post-drug Anxiety0.30.30.9-0.9-0.9-0.7-0.9-0.9-0.1-0.3-0.2-0.90.20.10.3-0.3-0.1-0.0
Baseline Anxiety0.40.41.3-0.6-0.5-0.20.10.4-0.4-0.7-0.80.0-1.1-1.0-0.2-0.7-0.9-0.7
Tail length0.72.95.9-0.9-0.9-0.30.30.7-2.4-2.1-2.41.0-2.1-2.1-1.9-2.1-1.8-1.8
Length with tail1.04.37.4-2.7-2.7-1.9-1.3-1.0-2.5-2.2-2.6-0.7-2.1-2.0-0.8-2.2-2.3-2.3
Length without tail1.03.46.6-2.3-2.3-1.5-1.0-0.8-1.8-1.7-2.0-0.7-2.0-1.9-0.2-2.1-2.6-2.5
Times rat made contact with spout0.50.61.7-0.8-0.7-0.8-0.20.3-1.3-1.3-1.10.3-0.8-0.7-0.9-0.5-0.2-0.2
Lifetime Intake3.54.310.11.41.40.7-0.1-0.83.23.22.8-1.02.42.32.52.42.01.8
Liver weight, left0.40.61.71.21.11.01.00.80.81.30.80.2-0.20.00.70.4-0.2-0.2
Liver weight, right0.91.53.41.81.81.31.81.61.11.81.30.6-0.5-0.40.90.8-0.0-0.2
Locomotor activity1.72.76.82.22.22.22.62.50.10.50.22.0-1.4-1.4-0.6-0.5-1.3-1.3
Locomotor testing distance2.03.69.12.42.52.53.03.00.00.6-0.22.3-1.8-1.8-0.5-0.6-1.6-1.6
Locomotor testing rearing1.32.77.52.22.32.12.72.70.20.4-0.22.1-1.5-1.6-0.2-0.3-1.1-1.0
Locomotion in novel chamber2.43.17.02.62.62.21.50.82.32.42.10.51.41.40.81.41.21.1
Locomotion in novel chamber post-restriction1.22.04.82.22.11.81.30.81.81.51.60.81.21.20.61.11.11.0
Fecal boli incidents, locomotor time 10.30.51.7-0.1-0.2-0.1-0.7-1.20.40.30.2-1.01.31.10.60.30.70.7
Change in fecal boli incidents, locomotor task0.10.10.4-0.2-0.0-0.40.10.40.40.60.30.1-0.6-0.30.40.4-0.1-0.3
Time >=10cm from walls, locomotor time 14.04.38.00.20.1-0.5-1.3-1.92.02.52.4-1.92.82.82.12.42.62.3
Bouts of movement, locomotor time 12.22.57.9-1.0-0.9-0.1-0.30.1-2.6-2.8-2.70.7-0.8-1.3-2.5-1.7-1.0-0.6
Total resting periods, locomotor time 11.41.65.2-0.8-0.7-0.1-0.4-0.1-2.2-2.2-2.30.4-0.3-0.8-2.2-1.2-0.6-0.3
Rest time, locomotor task time 10.50.72.21.51.51.51.00.60.51.00.20.50.50.3-0.30.30.20.2
Distance moved, locomotor task time 10.50.72.0-0.7-0.7-1.1-0.9-0.60.80.31.4-0.80.50.91.10.80.90.8
Vertical activity count, locomotor time 10.30.61.71.11.10.90.90.81.30.61.30.60.10.30.90.50.20.2
Time >=10cm from walls, locomotor time 20.20.31.0-0.2-0.3-0.1-0.7-1.0-0.4-0.20.0-0.41.00.7-0.40.20.60.7
Bouts of movement, locomotor time 20.30.52.4-0.7-0.6-0.5-0.30.1-0.9-1.6-1.20.4-0.3-0.5-0.9-0.6-0.4-0.2
Total resting periods, locomotor time 20.10.31.3-0.4-0.4-0.4-0.30.1-0.6-1.2-0.90.30.0-0.2-0.6-0.2-0.00.1
Rest time, locomotor task time 21.01.32.81.61.61.10.90.61.61.71.00.40.80.81.01.10.80.9
Distance moved, locomotor task time 20.70.82.0-1.1-1.1-0.6-0.5-0.3-1.4-1.4-0.70.1-0.8-0.8-1.0-1.1-0.9-0.8
Vertical activity count, locomotor time 21.11.52.70.50.51.11.31.3-1.0-0.9-0.41.4-1.6-1.6-1.1-1.4-1.6-1.6
Light reinforcement 10.20.41.00.50.50.60.70.8-0.6-0.5-0.61.0-0.5-0.7-0.8-0.5-0.5-0.6
Light reinforcement 20.60.92.21.11.01.20.2-0.61.51.21.2-0.31.41.20.70.60.60.4
Bone: marrow area2.75.912.90.40.4-0.5-1.0-1.43.43.53.3-2.32.53.03.62.92.22.1
Bone: maximum diameter0.71.23.7-0.5-0.7-0.3-1.2-1.91.31.11.0-1.61.31.41.30.40.00.1
Bone: maximum force2.74.811.8-2.9-3.0-3.0-3.3-3.40.90.50.6-3.21.41.62.30.70.70.6
Bone: maximum moment2.54.410.8-2.8-2.8-2.9-3.2-3.30.80.50.6-3.01.31.52.20.70.60.6
Mean time between licks in bursts0.40.92.7-0.5-0.5-0.30.40.8-1.1-0.7-0.90.5-1.6-1.4-0.6-0.8-1.2-1.3
Mean num. licks in bursts0.20.31.10.50.50.30.71.0-0.3-0.3-0.30.9-0.6-0.6-0.4-0.1-0.1-0.1
Cd content in liver0.70.81.61.31.11.00.5-0.01.20.71.00.31.31.10.50.60.80.9
Co content in liver3.23.78.51.71.71.92.62.9-1.3-1.3-1.42.9-2.0-2.1-2.0-1.4-1.3-1.2
Cu content in liver0.20.20.8-0.1-0.0-0.3-0.20.2-0.3-0.4-0.10.20.40.3-0.50.40.90.9
Fe content in liver0.20.20.7-0.3-0.4-0.1-0.2-0.5-0.10.4-0.0-0.6-0.3-0.30.5-0.3-0.9-0.8
K content in liver0.70.61.8-1.0-1.0-1.3-1.0-0.70.30.40.5-1.20.10.61.10.60.30.4
Mg content in liver0.20.20.60.30.3-0.10.30.50.50.60.6-0.0-0.00.40.70.70.60.6
Mn content in liver1.31.44.1-1.9-2.0-1.5-1.8-2.0-0.7-0.7-0.6-1.40.30.30.1-0.6-0.4-0.5
Na content in liver0.30.31.1-0.5-0.5-0.2-0.1-0.3-0.4-0.4-0.4-0.1-0.6-0.6-0.1-0.9-1.0-0.9
Rb content in liver0.81.02.81.51.61.11.41.71.00.70.71.0-0.20.10.60.70.30.5
Se content in liver0.30.31.00.50.30.5-0.1-0.60.40.60.7-0.31.01.00.10.40.50.5
Sr content in liver1.41.22.3-1.3-1.4-0.7-0.7-0.8-1.4-1.5-1.30.0-0.7-0.9-1.0-1.5-1.2-1.2
Zn content in liver0.30.31.0-0.7-0.7-0.7-0.40.0-1.0-0.8-0.70.1-0.3-0.3-0.8-0.20.20.2
Bone: minimum diameter2.54.68.30.30.3-0.7-1.0-1.12.92.62.7-1.82.42.82.82.72.42.5
Time in familiar zone, hab. session 10.50.50.90.30.30.0-0.1-0.10.90.80.9-0.40.70.90.80.90.90.8
Time in novel zone, hab. session 10.90.91.70.60.70.81.21.3-0.4-0.4-0.61.1-1.3-1.3-0.6-0.9-1.3-1.2
Total zone transitions, hab. session 10.30.41.3-1.0-1.0-1.1-0.9-0.6-0.6-0.8-0.6-0.30.10.1-0.2-0.10.40.4
Total locomotion distance, hab. session 10.60.81.50.20.3-0.3-0.3-0.31.11.11.1-0.71.01.11.21.21.11.2
Locomotion velocity, hab. session 10.30.40.9-0.2-0.2-0.6-0.6-0.50.50.60.6-0.70.70.80.70.90.91.0
Time in familiar zone, hab. session 20.60.61.90.20.10.20.80.9-0.6-0.0-0.50.6-1.4-1.1-0.3-0.6-1.2-1.3
Time in novel zone, hab. session 20.30.31.1-0.4-0.3-0.5-0.7-0.60.3-0.30.1-0.40.80.70.10.51.01.0
Total zone transitions, hab. session 21.72.25.9-2.0-1.9-2.4-2.1-1.60.30.20.4-1.90.81.11.31.11.51.4
Total locomotion distance, hab. session 21.21.62.9-0.7-0.6-1.4-1.1-0.71.21.21.2-1.40.91.31.71.61.61.5
Locomotion velocity, hab. session 21.62.13.7-0.5-0.4-1.2-1.1-1.01.51.51.6-1.61.31.71.91.91.81.8
Novel to familiar place preference ratio0.80.93.1-1.1-1.2-1.0-1.6-1.70.0-0.5-0.1-1.11.20.80.20.10.70.7
Novelty place preference0.50.61.8-0.7-0.8-0.7-1.2-1.30.1-0.4-0.0-0.71.10.80.10.20.80.8
Time in novel zone, NPP test0.40.41.3-0.6-0.7-0.6-1.0-1.10.1-0.3-0.0-0.60.90.70.20.20.70.7
Total zone transitions, NPP test1.21.75.1-2.2-2.1-2.3-2.1-1.7-0.5-0.6-0.5-1.60.30.50.60.10.40.4
Total locomotion distance, NPP test0.50.61.3-0.7-0.6-1.1-0.8-0.60.60.50.6-0.90.50.81.20.90.91.0
Locomotion velocity, NPP test0.40.61.1-0.7-0.6-1.0-0.9-0.60.40.30.4-0.80.60.80.80.81.01.0
Intraocular pressure0.60.93.31.71.51.81.20.4-0.60.2-0.00.90.6-0.1-1.5-0.4-0.2-0.2
Delta distance traveled before/after self-admin1.41.42.80.60.71.01.31.7-1.1-0.8-1.21.6-1.5-1.6-1.3-0.9-1.1-1.0
Delta ambulatory time before/after self-admin1.11.42.50.40.50.71.21.5-1.2-0.9-1.31.4-1.5-1.6-1.4-1.0-1.1-1.0
Parametrial fat weight2.25.111.02.42.31.40.80.33.13.03.3-0.32.42.41.92.72.42.3
Pavlov. Cond. lever latency0.40.51.30.80.81.11.00.9-0.1-0.2-0.20.9-0.4-0.5-0.5-0.5-0.6-0.5
Pavlov. Cond. magazine entry latency0.91.12.0-1.0-1.0-1.4-1.4-1.20.40.10.4-1.11.11.20.80.91.41.4
Pavlov. Cond. change in total contacts0.70.81.9-0.5-0.5-0.8-1.1-1.10.3-0.10.2-0.71.41.30.20.71.31.3
Pavlov. Cond. index score0.20.30.7-0.7-0.7-0.8-0.8-0.8-0.2-0.3-0.1-0.50.50.5-0.10.20.60.5
Pavlov. Cond. latency score0.30.30.8-0.6-0.7-0.9-0.8-0.70.00.00.1-0.60.60.60.20.40.80.6
Pavlov. Cond. lever contacts0.30.41.0-0.6-0.6-1.0-0.8-0.70.20.40.4-0.80.50.60.60.60.70.6
Pavlov. Cond. magazine entry number0.20.30.70.60.60.50.70.60.50.80.60.1-0.4-0.20.60.3-0.3-0.3
Pavlov. Cond. intertrial magazine entries0.40.51.51.11.11.21.00.7-0.3-0.10.01.00.1-0.1-1.1-0.2-0.1-0.1
Pavlov. Cond. lever-magazine prob. diff.0.40.51.3-0.9-0.9-1.1-1.1-1.0-0.2-0.3-0.1-0.70.70.70.00.30.80.7
Pavlov. Cond. response bias0.10.20.4-0.5-0.6-0.6-0.6-0.6-0.3-0.5-0.3-0.20.40.3-0.2-0.10.30.3
Pavlov. Cond. lever latency0.40.52.20.80.90.61.11.5-0.1-0.1-0.11.1-0.7-0.7-0.50.10.0-0.1
Pavlov. Cond. magazine entry latency2.02.46.9-2.6-2.6-2.5-2.4-2.0-1.2-1.3-1.0-1.50.30.30.1-0.30.10.3
Pavlov. Cond. change in total contacts1.11.85.4-1.6-1.7-1.5-2.2-2.3-0.2-0.6-0.1-1.51.51.30.20.20.91.1
Pavlov. Cond. index score1.41.95.4-2.0-2.1-1.9-2.3-2.3-0.4-0.6-0.3-1.71.01.00.50.00.40.6
Pavlov. Cond. latency score1.41.85.4-1.9-1.9-1.7-2.2-2.3-0.2-0.3-0.1-1.81.11.10.60.10.50.6
Pavlov. Cond. lever contacts0.40.52.1-0.9-0.9-0.6-1.1-1.4-0.00.00.0-1.10.70.70.4-0.1-0.00.1
Pavlov. Cond. magazine entry number3.03.710.23.23.22.72.92.61.61.91.51.7-0.4-0.20.20.80.1-0.0
Pavlov. Cond. intertrial magazine entries0.40.61.61.31.31.20.90.60.91.00.80.40.30.40.10.50.30.3
Pavlov. Cond. lever-magazine prob. diff.1.62.15.6-2.2-2.3-2.0-2.4-2.4-0.6-0.8-0.5-1.70.90.90.3-0.10.40.5
Pavlov. Cond. response bias1.11.54.1-1.8-1.9-1.6-2.0-2.0-0.5-0.6-0.4-1.50.70.70.4-0.20.10.3
Time in closed arm before self-admin0.50.72.00.40.40.1-0.4-0.70.60.90.7-0.61.41.30.20.91.11.1
Time in closed arm after self-admin0.10.10.40.50.50.30.40.50.30.60.40.2-0.10.00.30.50.30.2
Time in open arm before self-admin1.31.55.20.40.60.51.52.3-0.4-0.8-0.71.4-2.2-1.8-0.2-0.7-1.1-1.0
Time in open arm after self-admin0.40.40.9-0.2-0.10.00.40.6-0.7-1.0-0.60.7-0.9-0.9-0.5-0.8-0.8-0.6
Bone: periosteal estimation1.53.27.0-0.4-0.5-0.8-1.5-2.02.42.22.1-2.21.92.22.61.61.11.1
Bone: periosteal perimeter1.22.03.9-0.7-0.8-0.8-1.5-1.81.71.51.4-2.01.51.72.01.10.80.8
Bone: post-yield work8.712.720.1-2.0-2.0-3.1-3.9-4.03.22.63.1-4.34.14.54.03.73.93.9
Progressive ratio test 1 active lever presses0.40.51.60.60.50.4-0.1-0.61.31.10.9-0.31.10.81.00.60.40.4
Progressive ratio test 1 breakpoint0.40.51.60.50.50.4-0.1-0.71.31.10.9-0.41.10.81.00.60.40.4
Progressive ratio test 1 inactive lever presses0.00.10.20.40.40.30.2-0.00.2-0.1-0.10.20.4-0.1-0.3-0.00.00.1
Progressive ratio test 2 active lever presses1.92.24.91.81.61.40.4-0.52.22.11.8-0.12.01.61.21.31.11.0
Progressive ratio test 2 breakpoint1.92.14.81.81.61.50.5-0.52.22.01.8-0.02.01.51.21.31.00.9
Progressive ratio test 2 inactive lever presses3.15.111.03.33.22.71.50.52.92.62.60.82.52.10.92.02.01.8
Incentive Sensitization - Responses0.71.01.9-0.1-0.2-0.4-0.8-1.21.31.21.0-1.11.41.41.31.00.90.9
Incentive Sensitization - Breakpoint0.81.02.00.10.1-0.2-0.7-1.11.31.31.1-0.91.41.41.31.11.00.9
Sum of active levers in priming session hrs 5-61.11.02.5-0.3-0.50.6-0.4-1.3-1.5-0.8-1.2-0.20.3-0.3-1.4-1.6-1.3-1.4
Progressive ratio2.43.78.0-1.9-1.9-2.4-2.6-2.50.50.91.0-2.81.82.01.61.72.01.9
Food seeking constrained by brief footshock0.10.10.4-0.2-0.2-0.20.10.2-0.6-0.1-0.20.1-0.5-0.4-0.3-0.2-0.2-0.4
Seeking ratio, punishment vs. effort2.43.58.01.91.92.12.72.8-0.6-0.6-0.72.7-2.0-2.0-1.4-1.2-1.7-1.6
Retroperitoneal fat weight3.916.439.76.36.34.94.43.54.95.14.81.91.81.92.13.42.42.1
Reaction time number correct0.20.41.3-0.3-0.40.20.0-0.2-0.8-0.3-0.70.0-0.7-0.7-0.6-0.9-1.2-1.0
Reaction time mean minus median1.02.46.9-2.3-2.4-2.1-2.5-2.6-0.6-1.0-0.6-2.00.90.40.4-0.30.40.3
Reaction time mean minus median AUC0.41.02.7-1.5-1.6-1.2-1.5-1.7-0.9-1.0-0.8-1.20.3-0.3-0.2-0.7-0.2-0.3
Reaction time num false alarms0.60.93.30.70.80.71.41.8-0.3-0.1-0.41.2-1.5-1.2-0.5-0.3-0.8-0.7
Reaction time num false alarms AUC0.50.82.30.10.20.10.81.4-0.8-0.5-0.90.9-1.5-1.4-0.7-0.5-0.8-0.8
Reaction time trials correct on left0.20.41.3-0.3-0.40.20.0-0.2-0.8-0.3-0.70.0-0.7-0.7-0.6-0.9-1.2-1.0
Reaction time trials on left0.30.51.5-0.4-0.40.2-0.0-0.2-0.9-0.4-0.80.0-0.8-0.7-0.7-1.0-1.2-1.1
Reaction time mean0.10.20.6-0.2-0.2-0.1-0.5-0.60.2-0.6-0.4-0.50.80.3-0.00.00.50.6
Reaction time mean AUC0.20.30.9-0.2-0.2-0.2-0.6-0.70.2-0.5-0.2-0.61.00.50.00.20.80.8
Median of all reaction times0.10.20.60.30.30.3-0.1-0.10.5-0.3-0.1-0.20.80.50.00.30.70.8
Reaction time omissions0.71.12.6-1.6-1.5-1.2-1.4-1.3-0.9-1.3-1.3-1.10.1-0.3-0.5-0.6-0.2-0.2
Reaction time false alarm rate0.30.41.90.50.60.20.91.4-0.00.1-0.10.7-1.0-0.8-0.00.2-0.2-0.3
Reaction time premature initiation rate1.82.54.8-1.9-1.8-1.4-0.50.1-1.8-1.7-2.00.1-2.2-1.9-0.5-1.6-1.9-1.8
Reaction time premature initiations2.44.38.0-2.1-2.0-1.3-0.50.1-2.7-2.3-2.80.3-2.6-2.5-1.4-2.4-2.6-2.4
Std. dev. reaction times0.40.72.1-1.2-1.2-0.9-1.4-1.4-0.5-1.0-0.6-1.10.70.1-0.1-0.30.30.3
Reaction time trials completed0.30.51.5-0.4-0.40.2-0.0-0.2-0.9-0.4-0.80.0-0.8-0.7-0.7-1.0-1.2-1.1
Reaction time trials AUC0.20.41.3-0.3-0.30.20.1-0.1-0.7-0.2-0.70.1-0.8-0.7-0.6-0.8-1.1-1.0
Run reversals in cocaine runway, females0.90.92.6-1.1-1.0-1.6-0.9-0.30.80.60.7-1.1-0.10.51.21.11.00.8
Run reversals in cocaine runway, males1.01.02.01.11.01.41.41.00.30.1-0.21.2-0.9-1.0-0.0-1.0-1.4-1.4
Latency to leave start box in cocaine runway0.91.02.2-0.1-0.2-0.8-0.8-0.70.71.10.9-1.11.21.31.01.41.51.5
Latency to leave start box in cocaine runway, F0.30.31.4-0.1-0.1-0.6-0.5-0.2-0.10.10.1-0.30.70.70.10.81.11.2
Latency to leave start box in cocaine runway, M1.00.92.4-0.3-0.3-0.6-0.7-0.91.01.41.0-1.60.80.91.41.00.70.5
Std. dev. time between licks in bursts0.60.82.60.20.30.31.01.3-0.5-0.1-0.50.9-1.6-1.3-0.4-0.7-1.2-1.3
Total sessions with >9 infusions1.31.63.8-0.3-0.3-0.6-1.0-1.11.91.51.4-1.31.31.51.91.31.01.0
Short access day 1 total inactive lever presses1.11.43.01.71.71.21.10.91.71.71.40.40.70.30.51.20.90.7
Short access day 10 total inactive lever presses0.20.61.70.80.90.61.01.3-0.7-0.1-0.30.9-0.5-1.0-1.10.10.20.1
Short access day 1 total infusions1.82.46.11.01.00.3-0.0-0.32.52.42.1-0.61.61.71.92.01.71.5
Short access day 10 total infusions4.05.19.20.0-0.0-0.9-1.4-1.73.02.72.7-2.02.62.72.82.72.62.4
Short access total infusions2.43.06.50.20.2-0.5-0.8-1.12.52.62.2-1.51.81.92.52.11.71.5
Short access day 1 locomotion1.21.53.61.21.10.60.30.11.91.71.60.01.31.31.11.51.31.1
Short access day 10 total locomotion1.12.03.90.80.70.1-0.4-0.81.81.81.8-0.82.01.81.21.81.71.6
Short access total locomotion1.92.25.01.01.00.4-0.1-0.52.22.02.1-0.61.91.81.51.81.61.6
One hour access (0.3 mA shock)3.13.68.62.92.82.31.70.82.32.62.30.71.61.30.91.61.21.1
Compulsive drug intake3.44.18.9-1.2-1.1-0.60.51.5-2.9-2.5-2.71.0-3.0-2.6-1.8-2.1-2.3-2.1
One hour access (shock baseline)3.65.610.33.12.92.31.1-0.03.23.23.00.22.92.31.32.32.11.9
Social response proportion0.30.30.8-0.8-0.9-0.6-0.8-0.9-0.3-0.6-0.2-0.70.20.1-0.1-0.3-0.2-0.2
Social responses0.30.40.8-0.3-0.4-0.00.0-0.0-0.9-0.6-0.70.1-0.6-0.8-0.6-0.8-0.8-0.9
Social time0.40.61.2-0.5-0.4-0.10.10.1-0.9-0.7-1.00.1-0.9-1.1-0.6-1.0-1.1-1.1
Soleus weight1.64.713.03.63.62.92.72.32.22.42.31.30.70.90.51.51.11.1
Bone: stiffness2.13.38.7-2.4-2.4-2.4-2.9-2.90.60.10.5-2.51.51.51.60.60.80.8
Tibialis anterior weight3.913.335.2-5.8-5.9-4.4-4.3-4.2-3.5-3.1-3.3-3.1-1.6-1.8-0.7-3.1-2.8-2.8
Time to tail flick, vehicle, before self-admin0.80.81.7-0.7-0.8-0.9-1.1-1.20.90.50.6-1.20.80.91.30.70.70.6
Time to tail flick, vehicle, after self-admin1.62.15.6-1.5-1.6-2.4-1.8-1.40.61.00.8-1.90.71.21.91.41.31.2
Time to tail flick, test, before self-admin1.92.04.80.91.00.10.30.52.21.91.8-0.20.91.31.82.01.81.6
Time to tail flick, test, after self-admin0.10.10.5-0.1-0.20.1-0.3-0.7-0.00.2-0.1-0.40.40.20.5-0.1-0.2-0.1
Delta time to tail flick, vehicle, before/after SA0.40.41.8-0.9-0.9-1.4-0.8-0.5-0.30.2-0.0-0.8-0.00.20.60.50.40.4
Delta time to tail flick, test, before/after SA2.62.76.5-0.6-0.70.60.1-0.4-2.4-2.2-2.00.7-1.1-1.6-1.9-2.6-2.4-2.1
Tibia length0.51.46.5-1.3-1.6-0.8-1.8-2.6-0.3-0.3-0.2-1.51.21.10.0-0.7-0.4-0.3
Ambulatory time before self-admin0.81.23.1-0.9-1.0-1.0-1.5-1.80.20.20.8-1.21.51.40.60.61.01.0
Ambulatory time after self-admin0.30.31.10.30.30.2-0.1-0.1-0.4-0.00.40.30.90.7-0.80.51.01.1
Bone: tissue strength0.10.10.2-0.1-0.0-0.1-0.3-0.3-0.00.10.1-0.30.40.4-0.10.30.40.3
Total heroin consumption2.63.16.9-2.6-2.6-2.2-2.0-1.6-2.4-2.0-2.3-1.2-0.5-0.7-1.2-1.2-0.8-0.7
Bone: trabecular number1.42.34.5-1.5-1.5-1.8-2.1-2.10.80.60.9-2.01.51.71.41.11.31.3
Bone: trabecular spacing0.60.82.50.80.90.81.31.6-0.6-0.4-0.51.3-1.1-1.1-0.7-0.4-0.5-0.4
Bone: trabecular thickness0.60.71.40.40.4-0.1-0.2-0.21.11.01.1-0.51.01.00.61.21.11.2
Bone: trabecular tissue density1.62.37.52.72.72.52.11.71.01.21.11.40.50.3-0.40.60.40.4
Water consumed over 24 hours1.01.43.8-1.0-0.9-0.6-0.20.2-1.8-2.0-1.80.7-1.1-1.1-1.4-1.3-1.0-0.8
Number of responses in last shaping day0.30.40.90.20.20.30.60.7-0.6-0.4-0.40.7-0.8-0.9-0.6-0.5-0.8-0.8