Hub : Genes

Snx15

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Snx15 0.04 0.03 9.1e-05 0.01 0.03 0.03 0.02 1.0e-02 2.4e-04 5.7e-04 1.0e-03
2 NAcc gene expression Snx15 0.11 0.06 1.7e-12 0.06 0.11 0.11 0.11 1.8e-07 6.3e-13 1.5e-12 2.5e-12
3 pVTA gene expression Snx15 0.56 0.17 1.0e-10 0.19 0.18 0.18 0.2 1.3e-08 2.5e-08 1.8e-08 6.8e-09
4 Brain gene expression Snx15 0.21 0.09 2.7e-15 0.14 0.17 0.17 0.17 6.9e-13 1.3e-15 1.2e-15 1.5e-15
5 BLA gene expression Snx15 0.12 0.07 3.8e-05 0.05 0.05 0.07 0.06 8.1e-04 7.7e-04 1.7e-04 5.9e-04
6 PL mRNA stability Snx15 0.07 0.04 3.1e-05 0.03 0.03 0.03 0.03 1.2e-04 1.4e-04 1.9e-04 4.4e-04
7 Adipose mRNA stability Snx15 0.07 0.04 8.7e-05 0.03 0.02 0.02 0.02 8.3e-04 3.6e-03 5.7e-03 4.5e-03
8 Brain mRNA stability Snx15 0.55 0.13 0.0e+00 0.31 0.3 0.3 0.31 2.8e-29 2.6e-28 1.7e-28 2.1e-29
9 BLA mRNA stability Snx15 0.09 0.06 2.4e-03 0.04 0.04 0.03 0.04 2.2e-03 3.7e-03 6.3e-03 3.9e-03
10 LHb gene expression Snx15 0.72 0.16 2.0e-03 0.12 0.05 0.07 0.12 8.5e-04 2.9e-02 9.4e-03 7.2e-04
11 RMTg mRNA stability Snx15 0.28 0.13 5.8e-05 0.13 0.09 0.13 0.11 2.5e-04 2.0e-03 3.1e-04 6.5e-04
12 NAcc mRNA stability Snx15 0.13 0.07 5.0e-09 0.05 0.05 0.06 0.05 7.0e-07 9.6e-07 4.4e-07 1.4e-06
13 OFC mRNA stability Snx15 0.3 0.14 1.1e-03 0.05 0.08 0.04 0.07 2.3e-02 6.0e-03 4.7e-02 1.1e-02
14 LHb mRNA stability Snx15 0.67 0.17 3.0e-04 0.05 0.03 0.1 0.12 2.3e-02 6.4e-02 2.4e-03 1.0e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density1.42.33.9-1.3-1.6-1.91.81.7-1.1-1.11.2-1.0-2.0-1.0-1.41.71.6
Area under the delay curve0.10.20.8-0.3-0.30.00.20.4-0.3-0.20.00.1-0.2-0.80.00.40.9
BMI with tail4.815.431.2-4.6-4.9-5.45.65.5-2.1-2.02.3-2.2-5.3-1.3-2.83.53.3
BMI without tail1.83.78.7-2.7-2.8-2.72.82.9-0.6-0.70.9-0.5-2.4-0.5-1.01.51.6
Body weight2.29.325.0-4.7-4.7-4.54.55.00.50.5-0.40.3-3.91.5-0.51.20.5
Weight adjusted by age1.01.12.1-1.4-1.4-1.21.21.30.70.9-1.01.5-1.21.20.00.0-0.4
Bone surface3.25.614.0-3.1-3.4-3.73.53.3-0.3-0.40.4-0.5-3.40.4-1.72.11.2
Bone volume2.33.88.2-1.9-2.3-2.92.72.3-0.9-1.01.0-1.1-2.7-0.6-2.12.31.6
Breakpoint value in progressive ratio session1.21.33.3-1.8-1.8-1.41.31.11.01.0-1.11.2-1.01.0-0.10.30.1
Number of licking bursts0.10.10.3-0.5-0.6-0.50.50.20.20.2-0.20.4-0.30.1-0.30.30.3
Context. condit. distance diff. score0.70.81.71.31.31.0-1.0-0.8-1.0-0.91.0-1.10.6-1.0-0.10.10.3
Locomotion velocity, session 10.20.31.0-0.10.10.2-0.20.40.40.4-0.40.10.20.80.9-0.8-1.0
Locomotion distance, session 10.70.92.7-1.4-1.3-1.21.31.6-0.4-0.40.3-0.1-1.3-0.2-0.30.60.5
Locomotion velocity, session 21.61.95.1-2.3-2.2-1.91.92.00.40.3-0.40.9-1.60.8-0.20.50.5
Locomotion distance, session 20.50.72.1-1.5-1.3-0.91.21.40.10.1-0.10.4-1.00.1-0.00.30.5
Locomotion velocity, session 31.21.43.1-0.3-0.3-0.91.01.3-1.5-1.51.5-1.8-1.4-1.0-0.81.00.9
Locomotion distance, session 30.00.00.10.10.10.00.00.2-0.3-0.20.2-0.3-0.1-0.20.00.00.0
Stereotopy head waving bouts, day 31.31.54.80.0-0.0-0.70.91.2-1.7-1.71.8-2.2-1.3-1.0-0.80.80.7
Stereotopy head waving duration, day 30.60.82.60.50.4-0.10.20.2-1.3-1.31.4-1.6-0.6-0.9-0.70.60.6
Locomotion velocity, session 71.92.13.7-0.1-0.3-0.81.00.9-1.8-1.71.8-1.7-1.4-1.8-1.51.61.9
Locomotion distance, session 70.20.30.8-0.3-0.2-0.20.40.9-0.8-0.70.7-0.6-0.6-0.7-0.10.30.5
Stereotopy head waving bouts, day 70.70.81.90.1-0.1-0.50.6-0.0-0.9-0.91.1-1.1-0.7-1.1-1.41.21.4
Stereotopy head waving duration, day 70.91.12.1-1.3-1.5-1.41.50.9-0.1-0.10.2-0.2-1.2-0.4-1.11.21.3
Locomotion velocity, session 80.70.92.5-0.9-0.8-0.40.41.00.80.8-0.80.7-0.21.61.3-1.0-1.2
Locomotion distance, session 80.71.02.2-0.1-0.3-0.80.80.9-1.5-1.41.4-1.2-1.2-0.8-0.91.00.8
Degree of sensitization distance0.70.71.2-0.4-0.5-0.90.81.1-1.0-1.01.0-1.0-1.0-0.7-0.60.70.5
Degree of sensitization stereotypy0.60.71.6-0.7-0.9-1.01.10.4-0.1-0.20.3-0.3-0.9-0.5-1.21.11.2
Conditioned locomotion0.80.91.9-1.4-1.3-1.11.01.30.70.8-0.70.5-0.81.20.6-0.4-0.8
Cocaine response after cond. corrected0.50.51.31.11.20.9-0.8-0.4-0.7-0.80.9-1.00.4-0.50.5-0.4-0.3
Cocaine response after cond. not corrected0.40.40.90.90.90.6-0.5-0.2-0.9-0.90.9-0.90.1-0.40.3-0.3-0.2
Cocaine response before conditioning0.30.30.8-0.8-0.9-0.80.80.60.30.3-0.40.6-0.60.4-0.40.40.2
Saline control response1.92.45.7-2.4-2.2-1.61.72.11.31.3-1.41.5-1.21.80.8-0.6-0.8
Bone: connectivity density1.93.06.5-2.4-2.5-2.52.52.5-0.4-0.40.4-0.1-2.4-0.1-1.11.51.3
Bone: cortical apparent density0.70.92.4-0.4-0.10.8-0.6-0.51.61.4-1.51.51.10.50.8-0.8-0.2
Bone: cortical area0.40.51.6-0.9-1.0-1.31.10.9-0.0-0.00.0-0.2-1.10.4-0.40.5-0.1
Bone: cortical porosity0.30.30.8-0.6-0.6-0.50.60.5-0.3-0.30.3-0.3-0.6-0.4-0.50.60.9
Bone: cortical porosity0.30.41.1-1.0-1.0-0.80.80.80.10.1-0.10.2-0.70.1-0.20.30.5
Bone: cortical thickness1.72.85.5-1.6-1.3-0.20.20.82.32.2-2.32.30.42.31.8-1.5-1.6
Bone: cortical thickness1.51.84.1-0.4-0.10.8-0.70.31.61.6-1.71.41.01.52.0-1.7-1.7
Bone: cortical tissue density0.81.12.9-0.4-0.10.8-0.6-0.41.71.6-1.61.61.20.60.9-0.9-0.3
Condit. Reinf. active minus inactive responses0.10.10.3-0.6-0.5-0.10.30.30.30.2-0.30.4-0.1-0.1-0.00.10.4
Condit. Reinf. active-inactive response ratio0.20.20.5-0.10.10.6-0.4-0.50.70.7-0.70.60.60.00.3-0.30.1
Condit. Reinf. active responses0.30.30.5-0.4-0.5-0.60.70.5-0.5-0.60.5-0.1-0.7-0.5-0.70.70.6
Condit. Reinf. inactive responses1.21.42.5-0.2-0.5-1.21.10.8-1.6-1.61.5-1.0-1.5-0.9-1.41.40.7
Incentive salience index mean0.40.51.1-1.0-1.0-0.91.01.0-0.3-0.30.20.1-0.9-0.3-0.50.60.7
Condit. Reinf. lever presses0.81.02.4-1.0-1.1-1.51.51.2-0.7-0.80.7-0.3-1.5-0.1-0.91.00.4
Condit. Reinf. active minus inactive responses0.40.51.20.30.1-0.40.30.1-0.8-0.70.7-0.9-0.5-0.9-1.11.00.9
Condit. Reinf. active-inactive response ratio2.12.24.40.60.2-1.00.90.3-2.0-1.91.9-1.9-1.3-1.5-2.11.91.4
Condit. Reinf. active responses0.20.20.9-0.3-0.3-0.30.40.3-0.1-0.10.0-0.1-0.4-0.7-0.70.70.9
Condit. Reinf. inactive responses0.40.51.3-0.8-0.50.3-0.10.21.01.0-1.11.10.40.20.7-0.50.2
Condit. Reinf. lever presses1.11.53.7-1.6-1.8-1.91.81.60.20.3-0.30.2-1.70.6-0.91.00.6
Condit. Reinf. lever reinforcers received0.20.20.5-0.5-0.6-0.50.50.40.20.3-0.30.2-0.4-0.3-0.60.60.7
Conditioned reinforcement - actives0.20.20.70.80.5-0.0-0.2-0.6-0.6-0.60.4-0.60.0-0.1-0.80.5-0.1
Conditioned reinforcement - inactives3.23.59.73.12.82.1-2.2-2.8-1.4-1.51.2-1.11.6-2.0-1.00.60.5
Conditioned locomotion4.25.014.23.83.62.7-2.9-3.3-1.4-1.51.5-1.72.2-1.6-0.4-0.1-0.2
Patch foraging indifference point 0 sec0.00.00.10.20.20.2-0.2-0.2-0.4-0.20.2-0.3-0.0-0.3-0.10.10.2
Patch foraging indifference point AUC1.31.53.2-1.8-1.8-1.41.11.21.61.3-1.41.2-0.51.30.20.1-0.2
Delay disc. indifference point, 0s delay0.20.20.9-0.1-0.10.10.10.2-0.7-0.60.4-0.3-0.1-1.00.10.30.8
Delay disc. indifference point, 16s delay0.70.72.80.70.60.6-0.4-0.7-0.9-0.60.7-0.60.2-1.7-0.80.81.4
Delay disc. indifference point, 2s delay0.20.30.70.0-0.1-0.40.30.3-0.7-0.70.8-0.7-0.4-0.5-0.50.50.5
Delay disc. indifference point, 24s delay0.60.51.50.20.40.8-0.7-0.10.70.7-0.91.20.70.31.1-0.9-0.6
Delay disc. indifference point, 4s delay0.10.10.6-0.1-0.00.3-0.10.2-0.1-0.2-0.20.80.3-0.40.6-0.20.3
Delay disc. indifference point, 8s delay0.10.10.5-0.2-0.10.4-0.10.3-0.00.1-0.30.10.0-0.20.7-0.30.1
Indifference point function ln k3.14.310.53.13.22.5-2.4-2.0-2.1-2.02.0-2.01.7-2.00.2-0.6-0.2
Indifference point function log k3.14.310.53.13.22.5-2.4-2.0-2.1-2.02.0-2.01.7-2.00.2-0.6-0.2
Patch foraging total patch changes 0 sec0.10.10.20.20.30.5-0.5-0.30.00.2-0.20.10.40.20.5-0.4-0.4
Patch foraging total patch changes 12 sec1.72.36.1-2.5-2.4-1.71.61.81.51.5-1.51.3-1.01.30.30.10.1
Patch foraging total patch changes 18 sec0.40.51.2-0.9-1.1-1.00.90.90.1-0.10.00.2-0.80.1-0.60.70.6
Patch foraging total patch changes 24 sec1.21.43.4-1.4-1.3-0.80.71.01.41.4-1.51.5-0.41.90.7-0.7-1.0
Patch foraging total patch changes 6 sec0.30.51.6-1.3-1.2-0.90.81.20.50.4-0.40.3-0.40.70.3-0.1-0.1
Patch foraging time to switch 0 sec2.64.07.7-2.3-2.6-2.72.82.4-0.8-0.80.9-0.6-2.7-0.8-1.92.12.1
Patch foraging water rate 0 sec2.84.511.33.33.42.9-3.1-3.0-0.1-0.20.2-0.42.7-0.01.1-1.6-1.8
Patch foraging water rate 12 sec5.58.520.14.24.54.2-4.2-3.8-0.0-0.30.3-0.53.9-0.22.0-2.5-2.3
Patch foraging water rate 18 sec1.52.05.32.22.32.0-1.9-1.6-0.6-0.80.6-0.71.6-0.41.0-1.2-1.2
Patch foraging water rate 24 sec2.23.07.92.72.82.3-2.3-2.3-0.4-0.60.7-0.92.1-0.20.9-1.3-1.4
Patch foraging water rate 6 sec2.63.99.22.83.02.7-2.7-2.3-0.2-0.30.3-0.32.60.11.6-2.0-1.9
Seeking ratio, delayed vs. immediate footshock0.10.20.8-0.10.00.40.0-0.5-0.10.10.2-0.2-0.2-0.9-0.20.30.9
Distance traveled before self-admin0.40.41.1-0.8-0.9-1.00.90.60.20.1-0.20.2-0.80.2-0.70.70.4
Distance traveled after self-admin0.10.10.3-0.3-0.3-0.20.2-0.30.50.4-0.30.4-0.20.1-0.30.20.2
Extensor digitorum longus weight3.413.635.8-6.0-5.8-4.84.85.52.32.3-2.22.0-3.93.10.40.4-0.2
Bone: elastic displacement2.02.34.01.61.82.0-2.0-1.50.70.6-0.60.51.90.81.8-1.9-1.9
Bone: elastic work1.21.53.6-0.6-0.30.4-0.30.61.41.3-1.41.10.61.61.9-1.7-1.9
Bone: endosteal estimation2.75.811.90.3-0.2-1.91.71.2-3.4-3.23.4-3.5-2.5-2.3-2.62.51.8
Bone: endosteal perimeter3.47.015.10.6-0.0-2.01.70.9-3.6-3.53.6-3.9-2.6-2.5-3.23.02.1
Epididymis fat weight1.53.57.22.11.80.4-0.6-1.0-2.6-2.62.7-2.6-0.1-2.3-1.71.41.2
Delta time in closed arm before/after self-admin0.50.52.2-0.30.00.2-0.20.50.40.3-0.60.60.30.71.5-1.2-1.0
Delta time in open arm before/after self-admin0.10.10.40.1-0.0-0.0-0.2-0.60.30.3-0.30.50.2-0.0-0.60.50.3
Diff in mean of infusions in LGA sessions0.50.52.9-0.3-0.30.0-0.1-0.10.90.8-1.21.70.10.80.6-0.5-0.6
Delay discount exponential model param0.10.10.50.30.3-0.0-0.2-0.40.10.10.1-0.30.10.6-0.2-0.2-0.7
Extinction: sum of active levers before priming2.22.26.1-2.5-2.5-1.81.91.90.90.9-1.01.0-1.40.5-0.40.70.8
Active lever presses in extinction session 61.11.02.7-1.1-1.3-1.31.00.70.90.9-1.11.1-0.71.70.0-0.1-0.9
Bone: final force1.72.76.9-2.4-2.5-2.52.42.60.30.3-0.30.1-2.11.0-0.50.7-0.0
Bone: final moment1.52.45.8-2.3-2.4-2.42.32.40.30.2-0.20.1-2.01.0-0.40.7-0.0
Food consumed during 24 hour testing period0.30.30.80.30.30.4-0.5-0.90.70.7-0.80.80.60.50.2-0.4-0.5
Glucose1.82.75.71.00.8-0.40.4-0.0-2.3-2.42.4-2.2-0.9-2.2-1.61.61.7
Heart weight1.31.94.02.01.91.3-1.2-1.4-1.6-1.51.5-1.50.7-1.7-0.20.20.5
Delay discount hyperbolic model param0.10.10.40.30.30.0-0.2-0.40.10.10.1-0.20.10.5-0.2-0.2-0.6
Intermittent access intake day 1-15 change0.60.61.91.41.20.9-1.1-1.4-0.2-0.20.10.10.90.0-0.2-0.1-0.6
Intermittent access intake escalation0.40.41.41.21.00.7-0.9-1.1-0.3-0.30.30.00.7-0.3-0.40.2-0.2
Intermittent access intake escalation 20.50.41.20.90.80.8-0.9-1.10.40.3-0.50.60.90.3-0.1-0.2-0.6
Intermitt. access day 1 inactive lever presses1.21.32.91.71.61.2-1.2-1.3-0.9-1.01.0-1.20.9-1.5-0.50.50.6
Intermitt. access day 15 inactive lever presses1.51.63.92.01.71.0-1.1-1.6-1.3-1.41.1-1.20.6-1.5-1.10.90.6
Intermitt. access escalation Index1.71.53.51.21.21.0-0.8-1.1-1.4-1.31.7-1.80.5-1.9-0.40.41.1
Intermittent access day 1 total infusions5.76.514.11.71.2-0.10.1-0.5-3.7-3.83.7-3.6-1.0-3.5-2.62.52.5
Intermittent access day 15 total infusions5.15.810.73.02.51.1-1.2-1.9-3.3-3.33.1-3.00.3-2.9-2.21.81.4
Intermittent access terminal intake (last 3 days)4.95.311.32.31.70.2-0.4-1.1-3.3-3.43.3-3.1-0.3-2.8-2.62.21.6
Intermittent access total infusions4.85.311.51.91.3-0.0-0.1-0.8-3.3-3.43.3-3.1-0.7-3.0-2.62.42.0
Intermittent access day 1 locomotion4.34.510.21.10.8-0.20.3-0.1-3.1-3.23.2-3.1-1.0-2.9-1.71.92.1
Intermittent access day 15 total locomotion3.23.56.22.31.90.9-1.0-1.5-2.5-2.52.3-2.30.3-2.5-1.71.51.3
Intermittent access total locomotion6.57.415.82.11.4-0.0-0.0-0.8-3.9-4.03.8-3.6-0.8-3.7-3.02.82.6
Intermittent access standard deviation0.70.72.31.51.30.9-1.1-1.3-0.5-0.60.5-0.50.9-0.5-0.40.1-0.2
Left kidney weight0.41.01.81.31.10.5-0.5-0.8-1.3-1.11.3-1.30.0-1.3-1.10.80.6
Right kidney weight0.20.41.70.90.6-0.1-0.2-0.4-0.7-0.60.8-1.30.0-0.4-1.00.70.0
Cocaine induced anxiety0.10.10.30.1-0.1-0.40.30.2-0.3-0.30.20.1-0.40.1-0.60.4-0.1
Post-drug Anxiety0.60.71.6-0.9-1.0-1.21.00.90.40.5-0.50.5-1.01.3-0.40.1-0.8
Baseline Anxiety1.21.22.7-1.4-1.3-0.90.81.11.21.3-1.41.1-0.41.60.9-0.7-0.9
Tail length1.23.66.8-0.7-0.40.5-0.70.12.42.4-2.52.51.12.62.4-2.3-2.5
Length with tail1.14.08.7-2.2-2.0-1.21.11.82.32.4-2.52.4-0.63.01.7-1.5-2.2
Length without tail0.92.04.4-2.0-1.9-1.71.72.11.01.1-1.10.8-1.51.80.5-0.3-1.0
Times rat made contact with spout0.50.62.0-0.7-0.50.3-0.10.21.21.1-1.21.40.50.50.8-0.60.1
Lifetime Intake4.34.810.71.61.2-0.10.0-0.6-3.2-3.33.1-3.0-0.8-2.9-2.32.22.0
Liver weight, left0.10.20.70.10.0-0.30.20.6-0.4-0.60.6-0.9-0.2-0.3-0.30.30.0
Liver weight, right0.20.31.00.0-0.0-0.50.31.0-0.7-0.70.9-0.8-0.60.10.2-0.2-0.7
Locomotor activity1.62.65.32.12.32.3-2.2-1.70.2-0.0-0.10.02.10.51.6-1.7-1.8
Locomotor testing distance2.33.97.92.42.82.8-2.7-1.90.30.0-0.20.12.50.72.2-2.3-2.2
Locomotor testing rearing1.62.55.42.02.32.3-2.2-1.70.3-0.1-0.2-0.22.00.21.7-1.6-1.5
Locomotion in novel chamber2.63.26.62.62.20.9-1.1-1.6-2.5-2.32.2-1.90.2-1.9-1.81.20.6
Locomotion in novel chamber post-restriction1.62.04.52.01.81.0-1.2-1.4-1.5-1.51.6-2.10.9-1.4-0.80.50.4
Fecal boli incidents, locomotor time 10.60.72.0-0.1-0.5-0.80.8-0.0-0.6-0.70.6-0.8-1.2-0.5-1.41.30.8
Change in fecal boli incidents, locomotor task0.20.21.0-0.4-0.2-0.20.31.0-0.2-0.3-0.0-0.1-0.10.10.7-0.5-0.3
Time >=10cm from walls, locomotor time 14.24.39.00.1-0.5-1.71.50.8-3.0-2.82.5-1.7-2.0-2.2-2.72.62.1
Bouts of movement, locomotor time 11.71.95.7-0.8-0.50.5-0.2-1.22.32.1-2.22.40.81.01.0-0.7-0.1
Total resting periods, locomotor time 11.11.24.6-0.7-0.50.3-0.0-1.11.81.6-1.72.10.50.60.5-0.30.2
Rest time, locomotor task time 10.60.72.11.41.40.8-1.0-1.4-0.4-0.80.40.11.0-0.10.0-0.2-0.4
Distance moved, locomotor task time 10.70.71.9-0.7-0.8-0.80.91.2-0.9-0.40.7-0.5-1.4-0.8-0.70.80.9
Vertical activity count, locomotor time 10.60.61.51.21.20.9-0.9-0.7-1.0-0.60.7-1.10.2-0.9-0.20.00.1
Time >=10cm from walls, locomotor time 20.20.30.7-0.2-0.3-0.50.5-0.4-0.4-0.1-0.00.4-0.7-0.4-0.80.80.7
Bouts of movement, locomotor time 20.50.62.2-0.6-0.40.3-0.1-0.11.31.4-1.51.10.20.20.6-0.30.2
Total resting periods, locomotor time 20.30.31.3-0.4-0.30.3-0.1-0.11.01.0-1.20.80.1-0.10.4-0.10.5
Rest time, locomotor task time 21.01.23.11.51.40.8-0.7-0.7-1.2-1.81.3-1.30.8-1.2-0.50.50.5
Distance moved, locomotor task time 20.60.61.6-1.0-0.8-0.50.40.50.71.2-1.01.3-0.41.00.5-0.5-0.5
Vertical activity count, locomotor time 21.31.43.40.60.81.1-1.2-0.60.61.1-1.01.10.91.41.5-1.7-1.8
Light reinforcement 10.40.61.50.70.91.1-1.1-0.80.60.6-0.70.61.20.40.7-0.8-0.4
Light reinforcement 20.71.02.11.31.00.1-0.3-0.8-1.2-1.01.2-1.5-0.1-1.0-1.31.00.7
Bone: marrow area2.75.811.80.3-0.2-1.81.61.2-3.4-3.33.4-3.4-2.5-2.3-2.62.51.9
Bone: maximum diameter0.71.23.0-0.4-0.8-1.71.40.9-1.0-1.01.0-1.2-1.7-0.0-1.41.20.2
Bone: maximum force3.35.613.2-3.0-3.2-3.63.53.6-0.6-0.60.6-0.9-3.40.2-1.72.01.2
Bone: maximum moment2.94.911.5-2.8-3.0-3.43.33.3-0.6-0.70.6-0.8-3.20.1-1.51.91.1
Mean time between licks in bursts0.91.23.0-0.8-0.40.2-0.10.61.21.1-1.11.20.51.51.7-1.5-1.6
Mean num. licks in bursts0.20.30.80.40.50.9-0.8-0.50.40.4-0.40.40.80.00.7-0.6-0.1
Cd content in liver0.70.82.71.61.41.0-1.2-1.3-0.4-0.50.5-0.70.9-0.4-0.50.2-0.0
Co content in liver3.74.39.51.82.23.1-2.9-2.41.41.3-1.51.23.10.62.2-2.3-1.3
Cu content in liver0.20.20.5-0.7-0.6-0.10.2-0.10.40.5-0.50.7-0.0-0.2-0.00.20.6
Fe content in liver0.20.20.6-0.3-0.4-0.80.60.7-0.3-0.40.2-0.1-0.70.4-0.30.3-0.4
K content in liver2.32.25.2-1.9-2.0-2.22.22.3-0.6-0.70.6-0.5-2.1-0.2-0.81.10.9
Mg content in liver1.61.62.9-1.0-1.1-1.31.51.3-1.0-1.11.0-1.0-1.5-1.3-1.21.51.7
Mn content in liver1.11.23.0-1.6-1.7-1.71.61.40.50.4-0.50.5-1.40.8-0.60.6-0.1
Na content in liver0.50.51.3-1.0-1.0-1.20.91.10.40.2-0.30.1-0.90.9-0.10.1-0.6
Rb content in liver0.70.92.81.00.90.6-0.6-0.3-1.1-1.01.1-1.50.3-1.7-0.50.61.0
Se content in liver0.60.82.60.1-0.3-0.90.7-0.0-0.8-0.90.8-0.4-0.9-0.7-1.61.41.0
Sr content in liver1.81.73.8-1.2-1.1-0.20.20.31.91.8-1.91.70.31.91.0-0.9-1.3
Zn content in liver0.40.51.6-1.3-1.2-0.70.80.50.70.7-0.80.7-0.50.3-0.00.30.4
Bone: minimum diameter2.44.58.60.2-0.2-1.41.30.8-2.7-2.72.8-2.9-1.9-2.6-2.42.52.4
Time in familiar zone, hab. session 10.50.51.10.20.1-0.30.30.2-0.9-0.91.0-1.0-0.4-0.9-0.80.70.6
Time in novel zone, hab. session 11.01.02.10.60.81.2-1.1-0.60.70.7-0.70.61.10.81.4-1.3-1.3
Total zone transitions, hab. session 10.30.41.1-1.1-1.0-0.50.70.70.50.6-0.60.7-0.50.1-0.10.20.4
Total locomotion distance, hab. session 10.50.81.50.1-0.0-0.50.50.4-1.2-1.21.2-1.0-0.8-1.2-0.91.01.1
Locomotion velocity, hab. session 10.30.40.8-0.3-0.3-0.60.60.5-0.8-0.70.7-0.4-0.8-0.8-0.70.80.9
Time in familiar zone, hab. session 20.60.62.40.20.30.5-0.50.10.40.4-0.30.60.60.91.4-1.3-1.6
Time in novel zone, hab. session 20.30.31.7-0.4-0.5-0.20.50.10.0-0.0-0.1-0.2-0.3-0.7-0.80.81.3
Total zone transitions, hab. session 21.62.14.5-2.1-2.1-1.92.12.1-0.4-0.30.3-0.2-1.9-0.5-0.91.21.4
Total locomotion distance, hab. session 21.11.52.2-0.8-0.9-1.31.41.3-1.3-1.21.2-1.1-1.5-1.2-1.01.21.5
Locomotion velocity, hab. session 21.52.12.9-0.6-0.8-1.51.51.2-1.6-1.61.6-1.4-1.7-1.4-1.41.61.7
Novel to familiar place preference ratio0.70.81.6-1.0-1.3-1.21.20.70.10.1-0.20.1-1.0-0.2-1.21.20.9
Novelty place preference0.50.51.2-0.7-0.9-0.80.80.30.10.1-0.10.0-0.7-0.4-1.11.11.0
Time in novel zone, NPP test0.30.30.8-0.6-0.7-0.60.70.30.10.0-0.1-0.0-0.6-0.3-0.90.90.8
Total zone transitions, NPP test1.31.84.9-2.2-2.2-1.91.92.00.40.4-0.50.7-1.60.5-0.40.70.6
Total locomotion distance, NPP test0.50.61.1-0.8-0.8-1.01.01.1-0.6-0.60.6-0.5-1.0-0.6-0.50.81.0
Locomotion velocity, NPP test0.40.51.1-0.8-0.8-0.91.00.9-0.5-0.50.4-0.3-0.9-0.6-0.60.81.1
Intraocular pressure0.71.04.11.71.51.0-1.2-2.0-0.3-0.20.00.90.8-0.2-0.40.0-0.3
Delta distance traveled before/after self-admin0.20.20.50.30.50.6-0.6-0.50.40.3-0.20.00.60.30.7-0.7-0.5
Delta ambulatory time before/after self-admin0.40.41.00.20.40.7-0.6-0.40.70.5-0.50.40.60.51.0-1.0-0.7
Parametrial fat weight2.24.38.81.20.8-0.20.3-0.2-2.9-2.92.9-2.7-0.9-3.0-2.42.22.1
Pavlov. Cond. lever latency0.50.61.40.91.01.1-1.2-1.00.40.5-0.40.11.10.10.7-0.7-0.3
Pavlov. Cond. magazine entry latency0.60.81.5-0.9-1.1-1.01.10.7-0.4-0.40.3-0.3-1.0-0.9-1.11.21.2
Pavlov. Cond. change in total contacts0.50.61.9-0.4-0.6-0.60.70.0-0.4-0.40.3-0.2-0.7-1.0-1.41.31.0
Pavlov. Cond. index score0.10.20.4-0.5-0.6-0.50.60.20.00.0-0.10.3-0.5-0.2-0.60.50.2
Pavlov. Cond. latency score0.20.20.5-0.5-0.6-0.60.70.4-0.2-0.20.20.1-0.6-0.3-0.60.60.3
Pavlov. Cond. lever contacts0.10.10.3-0.4-0.4-0.40.50.5-0.3-0.40.3-0.1-0.5-0.2-0.30.40.1
Pavlov. Cond. magazine entry number0.10.10.30.40.50.2-0.20.2-0.5-0.50.6-0.50.1-0.00.4-0.4-0.1
Pavlov. Cond. intertrial magazine entries0.50.62.21.21.21.1-1.2-1.50.0-0.00.00.21.1-0.2-0.0-0.2-0.2
Pavlov. Cond. lever-magazine prob. diff.0.30.30.8-0.8-0.9-0.70.80.40.10.1-0.10.3-0.7-0.1-0.60.70.4
Pavlov. Cond. response bias0.00.10.1-0.3-0.3-0.20.2-0.10.20.2-0.30.2-0.1-0.1-0.40.30.1
Pavlov. Cond. lever latency0.60.82.00.81.01.4-1.3-1.10.30.3-0.30.31.4-0.10.9-0.9-0.5
Pavlov. Cond. magazine entry latency1.51.84.9-2.2-2.2-1.61.71.70.90.9-1.01.1-1.30.7-0.20.50.7
Pavlov. Cond. change in total contacts1.31.73.6-1.6-1.8-1.91.81.10.20.2-0.20.2-1.6-0.3-1.51.61.6
Pavlov. Cond. index score1.41.84.2-1.9-2.0-2.01.91.60.20.3-0.30.4-1.70.3-1.01.21.0
Pavlov. Cond. latency score1.41.74.0-1.7-1.9-2.01.91.6-0.00.0-0.00.2-1.80.1-1.11.21.0
Pavlov. Cond. lever contacts0.20.30.9-0.5-0.7-0.90.80.60.10.2-0.20.3-0.80.6-0.30.4-0.0
Pavlov. Cond. magazine entry number2.53.18.32.92.92.1-2.2-2.1-1.4-1.41.5-1.41.7-1.00.4-0.7-0.7
Pavlov. Cond. intertrial magazine entries0.40.61.51.21.10.5-0.6-0.8-1.0-0.90.9-0.80.3-0.7-0.40.20.1
Pavlov. Cond. lever-magazine prob. diff.1.51.94.8-2.0-2.2-2.02.01.70.50.5-0.50.6-1.70.4-0.81.10.9
Pavlov. Cond. response bias0.81.02.5-1.4-1.6-1.51.41.20.50.6-0.60.6-1.30.7-0.50.60.4
Time in closed arm before self-admin0.40.41.1-0.2-0.4-0.80.70.4-0.7-0.50.6-0.4-0.8-0.4-1.11.00.6
Time in closed arm after self-admin0.10.10.4-0.00.0-0.10.20.5-0.6-0.50.30.0-0.3-0.30.1-0.00.1
Time in open arm before self-admin0.91.02.80.61.01.7-1.3-0.60.80.7-0.70.11.20.11.7-1.5-0.6
Time in open arm after self-admin0.91.02.00.70.91.4-1.3-1.41.01.0-0.90.41.30.41.0-1.0-0.7
Bone: periosteal estimation1.63.25.8-0.4-0.8-2.11.81.4-2.2-2.12.1-2.4-2.3-1.1-2.02.01.0
Bone: periosteal perimeter1.11.83.5-0.6-0.9-1.81.51.2-1.4-1.31.3-1.6-1.9-0.6-1.51.50.7
Bone: post-yield work9.112.420.6-2.0-2.6-3.93.92.7-3.2-3.13.2-3.1-4.3-2.9-4.44.54.2
Progressive ratio test 1 active lever presses1.61.63.61.91.71.1-1.1-1.5-1.3-1.41.3-1.40.7-1.5-0.80.60.5
Progressive ratio test 1 breakpoint1.41.53.51.91.71.1-1.2-1.5-1.1-1.21.2-1.40.8-1.2-0.60.40.3
Progressive ratio test 1 inactive lever presses0.60.71.41.21.21.0-1.0-1.0-0.6-0.60.5-0.60.8-1.1-0.10.10.5
Progressive ratio test 2 active lever presses2.83.05.52.31.90.9-1.1-1.6-2.2-2.22.1-1.90.4-2.1-1.81.31.0
Progressive ratio test 2 breakpoint2.93.38.12.82.51.6-1.7-2.2-2.0-2.01.8-1.70.9-1.9-1.30.80.5
Progressive ratio test 2 inactive lever presses5.05.810.63.32.81.6-1.8-2.5-2.8-2.82.7-2.71.0-3.1-2.21.71.6
Incentive Sensitization - Responses0.60.61.50.70.5-0.0-0.1-0.5-1.1-1.11.0-0.7-0.3-1.0-1.21.00.7
Incentive Sensitization - Breakpoint0.70.81.50.90.70.2-0.3-0.7-1.2-1.21.0-0.8-0.2-1.1-1.21.00.7
Sum of active levers in priming session hrs 5-60.80.72.9-0.4-0.6-0.80.4-0.10.90.9-1.21.7-0.11.5-0.30.0-1.0
Progressive ratio3.23.78.5-2.4-2.6-2.72.92.1-0.7-0.60.40.0-2.9-0.7-1.51.91.8
Food seeking constrained by brief footshock0.30.41.6-0.3-0.10.3-0.20.40.50.6-0.81.20.30.71.0-0.9-0.8
Seeking ratio, punishment vs. effort3.03.78.72.12.42.8-2.8-1.80.80.7-0.60.42.90.71.9-2.2-1.9
Retroperitoneal fat weight2.89.318.83.83.41.6-1.7-2.2-4.0-3.94.1-4.30.5-3.9-2.31.81.7
Reaction time number correct0.30.51.3-0.4-0.3-0.20.10.30.70.6-0.91.0-0.01.10.7-0.7-1.0
Reaction time mean minus median1.62.15.0-2.1-2.2-2.02.11.90.40.7-0.60.5-1.90.6-1.11.10.7
Reaction time mean minus median AUC0.70.91.9-1.3-1.4-1.21.21.10.70.8-0.80.8-1.00.8-0.40.3-0.0
Reaction time num false alarms0.50.72.00.50.81.3-1.0-0.40.20.3-0.30.41.00.31.4-1.3-0.9
Reaction time num false alarms AUC0.40.62.2-0.10.20.8-0.60.10.60.7-0.70.90.60.61.5-1.3-0.8
Reaction time trials correct on left0.30.51.3-0.4-0.3-0.20.10.30.70.6-0.91.0-0.01.10.7-0.7-1.0
Reaction time trials on left0.40.61.5-0.4-0.3-0.20.20.40.80.7-1.01.1-0.11.20.8-0.8-1.1
Reaction time mean0.10.10.5-0.1-0.2-0.10.3-0.20.00.3-0.3-0.1-0.4-0.3-0.70.60.6
Reaction time mean AUC0.20.20.8-0.1-0.2-0.10.3-0.2-0.10.1-0.2-0.2-0.5-0.5-0.90.80.9
Median of all reaction times0.10.20.50.30.20.2-0.0-0.5-0.20.0-0.0-0.4-0.2-0.6-0.70.60.7
Reaction time omissions0.50.71.6-1.2-1.1-0.60.80.80.91.2-1.30.8-0.90.70.2-0.00.1
Reaction time false alarm rate0.20.30.80.30.60.9-0.7-0.2-0.10.00.10.00.6-0.10.9-0.8-0.3
Reaction time premature initiation rate2.12.85.3-1.7-1.3-0.40.41.52.32.1-2.01.60.22.32.2-1.8-1.5
Reaction time premature initiations3.34.79.2-2.0-1.5-0.40.41.63.02.8-2.82.50.33.02.6-2.3-2.1
Std. dev. reaction times0.40.51.1-0.9-1.0-0.81.00.70.30.6-0.60.3-1.00.3-0.70.60.5
Reaction time trials completed0.40.61.5-0.4-0.3-0.20.20.40.80.7-1.01.1-0.11.20.8-0.8-1.1
Reaction time trials AUC0.30.41.1-0.3-0.2-0.10.10.40.60.5-0.70.8-0.01.10.8-0.8-1.0
Run reversals in cocaine runway, females1.21.13.2-1.5-1.3-1.31.41.8-0.5-0.70.6-0.8-1.2-0.6-0.10.51.1
Run reversals in cocaine runway, males1.00.92.71.11.11.0-1.2-0.50.40.3-0.30.01.31.01.0-1.2-1.6
Latency to leave start box in cocaine runway0.91.02.4-0.3-0.5-0.70.80.3-1.0-1.01.1-1.6-0.8-1.2-1.21.21.3
Latency to leave start box in cocaine runway, F0.20.31.1-0.3-0.4-0.10.3-0.1-0.2-0.10.3-0.6-0.3-0.8-0.60.71.1
Latency to leave start box in cocaine runway, M0.60.61.8-0.1-0.3-0.90.70.7-0.9-1.21.0-1.3-0.7-0.3-0.70.60.2
Std. dev. time between licks in bursts0.70.82.40.30.60.8-0.7-0.10.50.5-0.50.40.81.01.5-1.5-1.6
Total sessions with >9 infusions1.92.15.40.90.7-0.10.2-0.1-2.2-2.32.3-2.3-0.7-1.8-1.11.11.1
Short access day 1 total inactive lever presses1.82.04.02.01.91.3-1.2-1.4-1.6-1.71.5-1.40.6-2.0-0.60.60.9
Short access day 10 total inactive lever presses1.71.94.72.12.22.0-1.9-1.7-0.7-0.70.5-0.81.6-1.20.6-0.60.0
Short access day 1 total infusions3.13.37.21.00.80.00.1-0.4-2.5-2.52.6-2.6-0.7-2.7-1.81.72.0
Short access day 10 total infusions4.55.09.90.3-0.1-1.11.20.7-3.1-3.13.0-2.8-1.8-2.9-2.42.52.6
Short access total infusions2.62.96.40.50.2-0.60.70.3-2.5-2.52.5-2.4-1.3-2.2-1.71.71.7
Short access day 1 locomotion2.62.76.41.00.7-0.10.1-0.1-2.5-2.42.5-2.5-0.6-2.3-1.41.41.6
Short access day 10 total locomotion2.02.25.00.80.5-0.00.2-0.3-2.1-2.22.2-1.9-0.7-2.2-1.31.41.7
Short access total locomotion2.02.05.20.60.4-0.20.30.0-2.1-2.02.1-2.3-0.8-2.0-1.11.31.6
One hour access (0.3 mA shock)5.16.013.73.73.31.9-2.2-2.6-2.9-3.02.7-2.61.3-2.7-1.61.10.7
Compulsive drug intake3.43.47.3-1.4-0.80.3-0.20.62.72.7-2.42.50.92.22.4-2.1-1.5
One hour access (shock baseline)5.66.512.13.52.81.3-1.5-2.5-3.3-3.33.0-3.00.5-3.0-2.62.01.3
Social response proportion0.30.31.0-1.0-1.0-0.70.80.50.30.3-0.40.3-0.70.5-0.20.30.0
Social responses0.30.41.0-0.3-0.20.1-0.10.00.60.7-0.61.00.21.00.6-0.6-0.9
Social time0.40.51.5-0.5-0.3-0.00.00.20.80.8-0.90.80.01.20.9-0.8-1.1
Soleus weight1.54.510.93.33.11.9-2.0-2.3-2.3-2.32.4-2.31.1-2.3-0.90.40.5
Bone: stiffness2.64.19.3-2.5-2.8-3.12.92.8-0.4-0.40.4-0.5-2.8-0.1-1.71.91.4
Tibialis anterior weight4.415.233.8-5.8-5.7-4.54.44.93.33.3-3.33.2-3.44.81.2-0.7-1.9
Time to tail flick, vehicle, before self-admin1.01.02.3-1.0-1.2-1.41.41.5-0.6-0.60.4-0.6-1.2-0.1-0.91.00.6
Time to tail flick, vehicle, after self-admin1.31.44.1-1.8-1.8-1.71.72.0-0.3-0.10.3-0.2-1.40.4-0.00.40.3
Time to tail flick, test, before self-admin1.21.12.60.1-0.0-0.50.50.7-1.6-1.61.6-1.5-0.6-1.4-0.80.91.1
Time to tail flick, test, after self-admin0.10.10.2-0.00.00.0-0.1-0.10.30.3-0.2-0.20.40.50.2-0.3-0.4
Delta time to tail flick, vehicle, before/after SA0.30.30.9-0.9-0.9-0.60.60.90.20.2-0.00.2-0.50.30.4-0.10.1
Delta time to tail flick, test, before/after SA2.42.14.9-0.2-0.00.6-0.7-0.82.22.2-2.11.40.92.11.2-1.5-1.7
Tibia length0.51.34.6-1.2-1.6-2.11.61.10.20.2-0.20.5-1.41.1-1.21.1-0.2
Ambulatory time before self-admin0.50.51.3-0.5-0.8-1.10.90.4-0.1-0.20.2-0.1-0.9-0.1-1.11.00.6
Ambulatory time after self-admin0.40.51.40.2-0.0-0.30.3-0.6-0.5-0.60.6-0.6-0.4-1.0-1.21.11.1
Bone: tissue strength0.10.10.5-0.1-0.2-0.40.40.0-0.2-0.20.2-0.1-0.4-0.1-0.70.50.5
Total heroin consumption2.52.97.0-2.6-2.5-1.61.81.91.71.8-1.81.9-1.41.70.4-0.1-0.2
Bone: trabecular number1.32.13.8-1.2-1.5-1.91.71.4-1.0-1.01.0-0.9-1.9-0.9-1.61.81.6
Bone: trabecular spacing0.50.71.40.50.81.1-1.0-0.70.60.5-0.60.71.20.41.1-1.1-0.5
Bone: trabecular thickness0.70.81.90.50.3-0.10.1-0.1-1.1-1.11.1-1.1-0.4-1.4-1.01.11.2
Bone: trabecular tissue density1.52.16.02.42.31.7-1.8-2.1-1.0-1.11.1-1.01.3-1.2-0.40.00.0
Water consumed over 24 hours1.11.33.4-0.6-0.40.6-0.5-0.21.81.7-1.81.80.91.01.2-1.0-0.6
Number of responses in last shaping day0.80.92.21.41.51.4-1.4-1.2-0.2-0.10.2-0.11.2-0.20.6-0.7-0.6