Hub : Genes

Sltm

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 OFC intron excision ratio chr8_80114615_80115403 0.39 0.57 1.4e-03 0.1 0.09 0.1 0.1 2.0e-03 3.5e-03 2.0e-03 1.9e-03
2 NAcc intron excision ratio chr8_80097853_80111721 0.02 0.02 2.5e-03 0.02 0.01 0.01 0.01 9.5e-04 1.8e-03 2.2e-03 2.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density0.40.70.8-0.90.8
Area under the delay curve0.00.10.1-0.30.2
BMI with tail6.723.323.74.9-4.8
BMI without tail2.67.98.12.8-2.8
Body weight4.620.120.84.6-4.4
Weight adjusted by age5.17.79.12.5-3.0
Bone surface0.10.10.20.3-0.4
Bone volume0.00.00.00.0-0.1
Breakpoint value in progressive ratio session0.70.90.91.0-0.9
Number of licking bursts1.42.32.4-1.51.5
Context. condit. distance diff. score1.31.61.7-1.21.3
Locomotion velocity, session 11.81.92.11.3-1.5
Locomotion distance, session 10.10.10.2-0.40.3
Locomotion velocity, session 20.20.30.40.5-0.6
Locomotion distance, session 20.20.30.50.4-0.7
Locomotion velocity, session 30.00.00.0-0.10.0
Locomotion distance, session 31.92.02.1-1.41.4
Stereotopy head waving bouts, day 30.60.70.70.9-0.8
Stereotopy head waving duration, day 30.70.80.90.9-0.9
Locomotion velocity, session 71.61.81.9-1.31.4
Locomotion distance, session 71.72.22.4-1.41.5
Stereotopy head waving bouts, day 71.01.11.21.0-1.1
Stereotopy head waving duration, day 70.70.80.90.9-0.9
Locomotion velocity, session 80.40.50.50.7-0.7
Locomotion distance, session 80.60.91.0-1.00.9
Degree of sensitization distance0.30.30.3-0.50.6
Degree of sensitization stereotypy0.50.60.70.7-0.8
Conditioned locomotion0.10.20.2-0.50.3
Cocaine response after cond. corrected3.33.94.02.0-2.0
Cocaine response after cond. not corrected2.12.42.61.5-1.6
Cocaine response before conditioning0.91.11.1-1.11.0
Saline control response0.10.10.1-0.30.3
Bone: connectivity density0.91.31.5-1.21.1
Bone: cortical apparent density1.11.61.6-1.31.2
Bone: cortical area0.00.10.1-0.10.3
Bone: cortical porosity1.01.11.1-1.01.0
Bone: cortical porosity1.41.51.6-1.31.2
Bone: cortical thickness1.52.52.7-1.51.7
Bone: cortical thickness0.60.70.7-0.80.9
Bone: cortical tissue density1.11.51.5-1.21.2
Condit. Reinf. active minus inactive responses0.00.00.00.0-0.0
Condit. Reinf. active-inactive response ratio0.40.40.4-0.60.7
Condit. Reinf. active responses0.40.50.50.7-0.7
Condit. Reinf. inactive responses1.01.21.21.1-1.1
Incentive salience index mean0.00.00.00.2-0.1
Condit. Reinf. lever presses0.00.00.00.1-0.0
Condit. Reinf. active minus inactive responses3.74.85.42.3-2.1
Condit. Reinf. active-inactive response ratio1.11.31.41.2-1.1
Condit. Reinf. active responses2.33.23.51.9-1.7
Condit. Reinf. inactive responses0.10.10.20.4-0.3
Condit. Reinf. lever presses0.40.50.6-0.60.8
Condit. Reinf. lever reinforcers received1.52.12.51.6-1.3
Conditioned reinforcement - actives0.00.00.00.1-0.1
Conditioned reinforcement - inactives0.10.20.3-0.30.6
Conditioned locomotion0.40.50.6-0.80.6
Patch foraging indifference point 0 sec0.30.60.70.8-0.7
Patch foraging indifference point AUC0.30.40.50.7-0.5
Delay disc. indifference point, 0s delay0.40.50.5-0.70.7
Delay disc. indifference point, 16s delay0.30.30.4-0.60.6
Delay disc. indifference point, 2s delay0.10.10.1-0.40.3
Delay disc. indifference point, 24s delay0.30.30.4-0.60.6
Delay disc. indifference point, 4s delay0.30.30.3-0.60.5
Delay disc. indifference point, 8s delay0.00.00.00.1-0.1
Indifference point function ln k0.10.20.30.3-0.5
Indifference point function log k0.10.20.30.3-0.5
Patch foraging total patch changes 0 sec0.40.80.90.9-0.9
Patch foraging total patch changes 12 sec0.10.10.20.4-0.1
Patch foraging total patch changes 18 sec0.30.40.50.7-0.5
Patch foraging total patch changes 24 sec0.40.60.80.9-0.7
Patch foraging total patch changes 6 sec0.60.91.11.1-0.9
Patch foraging time to switch 0 sec1.53.23.2-1.81.8
Patch foraging water rate 0 sec2.34.95.22.2-2.3
Patch foraging water rate 12 sec3.98.18.72.8-2.9
Patch foraging water rate 18 sec0.40.50.80.5-0.9
Patch foraging water rate 24 sec0.50.70.80.8-0.9
Patch foraging water rate 6 sec1.72.52.81.5-1.7
Seeking ratio, delayed vs. immediate footshock0.40.50.60.8-0.6
Distance traveled before self-admin0.10.20.2-0.50.4
Distance traveled after self-admin0.81.01.11.0-1.0
Extensor digitorum longus weight8.433.234.15.7-5.8
Bone: elastic displacement0.40.40.50.6-0.7
Bone: elastic work0.00.00.00.2-0.2
Bone: endosteal estimation2.24.94.92.2-2.2
Bone: endosteal perimeter3.47.37.42.7-2.7
Epididymis fat weight0.00.00.0-0.1-0.0
Delta time in closed arm before/after self-admin1.41.31.7-1.31.0
Delta time in open arm before/after self-admin0.10.10.1-0.20.4
Diff in mean of infusions in LGA sessions0.91.11.11.0-1.0
Delay discount exponential model param0.00.00.00.1-0.1
Extinction: sum of active levers before priming0.40.50.50.7-0.7
Active lever presses in extinction session 60.50.50.50.7-0.7
Bone: final force0.30.50.60.8-0.6
Bone: final moment0.00.10.10.4-0.1
Food consumed during 24 hour testing period0.50.70.80.9-0.8
Glucose0.91.41.51.2-1.2
Heart weight0.71.01.11.1-1.0
Delay discount hyperbolic model param0.10.10.10.3-0.2
Intermittent access intake day 1-15 change0.51.11.2-1.11.0
Intermittent access intake escalation0.30.70.8-0.90.8
Intermittent access intake escalation 20.00.00.1-0.30.1
Intermitt. access day 1 inactive lever presses0.93.64.0-2.01.8
Intermitt. access day 15 inactive lever presses0.00.00.0-0.10.1
Intermitt. access escalation Index0.30.40.80.9-0.3
Intermittent access day 1 total infusions0.61.01.1-1.01.0
Intermittent access day 15 total infusions1.21.71.9-1.31.4
Intermittent access terminal intake (last 3 days)0.50.60.7-0.70.9
Intermittent access total infusions0.30.40.4-0.60.6
Intermittent access day 1 locomotion2.32.93.0-1.71.7
Intermittent access day 15 total locomotion1.42.53.4-1.81.3
Intermittent access total locomotion0.10.10.2-0.5-0.0
Intermittent access standard deviation0.30.50.6-0.80.7
Left kidney weight1.67.27.72.8-2.6
Right kidney weight2.29.910.83.3-3.0
Cocaine induced anxiety0.10.10.2-0.40.3
Post-drug Anxiety2.42.52.7-1.61.5
Baseline Anxiety0.60.70.8-0.80.9
Tail length0.00.00.00.00.1
Length with tail0.62.42.71.6-1.5
Length without tail3.812.112.63.6-3.4
Times rat made contact with spout0.70.81.1-1.00.8
Lifetime Intake0.10.10.2-0.30.4
Liver weight, left4.27.07.82.5-2.8
Liver weight, right1.42.42.51.6-1.5
Locomotor activity5.89.09.13.0-3.0
Locomotor testing distance3.25.86.12.3-2.5
Locomotor testing rearing1.53.13.21.8-1.7
Locomotion in novel chamber0.20.20.3-0.40.5
Locomotion in novel chamber post-restriction0.60.91.1-0.91.1
Fecal boli incidents, locomotor time 10.10.10.2-0.20.5
Change in fecal boli incidents, locomotor task0.10.10.20.2-0.4
Time >=10cm from walls, locomotor time 10.10.10.10.2-0.3
Bouts of movement, locomotor time 10.00.00.10.3-0.1
Total resting periods, locomotor time 10.00.00.10.2-0.2
Rest time, locomotor task time 10.00.00.0-0.1-0.1
Distance moved, locomotor task time 10.00.10.1-0.30.2
Vertical activity count, locomotor time 10.10.30.3-0.50.5
Time >=10cm from walls, locomotor time 20.00.10.10.2-0.3
Bouts of movement, locomotor time 20.81.31.31.1-1.1
Total resting periods, locomotor time 20.81.41.41.2-1.2
Rest time, locomotor task time 20.30.40.5-0.50.7
Distance moved, locomotor task time 20.00.00.0-0.0-0.2
Vertical activity count, locomotor time 20.40.60.7-0.80.7
Light reinforcement 12.66.46.62.6-2.5
Light reinforcement 20.00.10.1-0.20.3
Bone: marrow area2.24.84.92.2-2.2
Bone: maximum diameter2.24.04.22.0-2.0
Bone: maximum force0.20.40.50.7-0.6
Bone: maximum moment0.00.10.10.3-0.2
Mean time between licks in bursts0.20.60.7-0.80.7
Mean num. licks in bursts0.50.70.80.8-0.9
Cd content in liver1.51.71.8-1.21.4
Co content in liver1.31.51.7-1.31.2
Cu content in liver0.00.00.00.1-0.2
Fe content in liver0.20.30.30.5-0.5
K content in liver2.42.32.91.3-1.7
Mg content in liver1.91.92.21.3-1.5
Mn content in liver0.00.00.0-0.20.1
Na content in liver8.79.49.73.0-3.1
Rb content in liver0.60.70.90.7-1.0
Se content in liver0.00.00.1-0.20.1
Sr content in liver0.00.00.0-0.10.2
Zn content in liver0.10.10.20.2-0.5
Bone: minimum diameter0.10.10.2-0.20.4
Time in familiar zone, hab. session 10.00.00.0-0.0-0.1
Time in novel zone, hab. session 10.10.10.1-0.30.4
Total zone transitions, hab. session 10.20.30.4-0.60.5
Total locomotion distance, hab. session 10.00.00.0-0.20.1
Locomotion velocity, hab. session 10.00.00.00.0-0.2
Time in familiar zone, hab. session 20.00.00.1-0.10.3
Time in novel zone, hab. session 20.00.00.1-0.20.2
Total zone transitions, hab. session 20.50.60.70.8-0.8
Total locomotion distance, hab. session 20.91.21.31.0-1.1
Locomotion velocity, hab. session 20.50.60.70.8-0.9
Novel to familiar place preference ratio0.91.01.11.1-0.9
Novelty place preference0.91.01.21.1-0.9
Time in novel zone, NPP test1.11.21.41.2-1.0
Total zone transitions, NPP test0.40.60.80.6-0.9
Total locomotion distance, NPP test0.81.11.31.0-1.1
Locomotion velocity, NPP test0.40.50.70.6-0.8
Intraocular pressure0.00.00.0-0.0-0.0
Delta distance traveled before/after self-admin2.02.12.21.5-1.4
Delta ambulatory time before/after self-admin0.81.01.01.0-0.9
Parametrial fat weight1.02.32.6-1.61.5
Pavlov. Cond. lever latency0.20.20.2-0.50.5
Pavlov. Cond. magazine entry latency0.40.60.6-0.70.7
Pavlov. Cond. change in total contacts0.00.00.0-0.0-0.1
Pavlov. Cond. index score0.30.30.3-0.60.6
Pavlov. Cond. latency score0.00.10.1-0.30.2
Pavlov. Cond. lever contacts0.00.00.10.2-0.2
Pavlov. Cond. magazine entry number0.70.90.90.9-1.0
Pavlov. Cond. intertrial magazine entries0.10.10.10.3-0.3
Pavlov. Cond. lever-magazine prob. diff.0.10.10.1-0.40.4
Pavlov. Cond. response bias0.20.20.3-0.50.5
Pavlov. Cond. lever latency0.10.20.20.4-0.4
Pavlov. Cond. magazine entry latency3.23.94.1-2.01.9
Pavlov. Cond. change in total contacts0.20.40.4-0.60.6
Pavlov. Cond. index score0.70.91.0-1.00.9
Pavlov. Cond. latency score0.40.50.6-0.80.7
Pavlov. Cond. lever contacts0.10.10.2-0.40.4
Pavlov. Cond. magazine entry number3.13.84.12.0-1.9
Pavlov. Cond. intertrial magazine entries1.01.41.71.3-1.1
Pavlov. Cond. lever-magazine prob. diff.0.81.11.2-1.11.0
Pavlov. Cond. response bias1.11.51.5-1.21.2
Time in closed arm before self-admin0.20.30.4-0.60.4
Time in closed arm after self-admin1.31.41.8-1.31.0
Time in open arm before self-admin0.60.70.91.0-0.6
Time in open arm after self-admin0.50.60.80.9-0.6
Bone: periosteal estimation1.12.42.61.6-1.5
Bone: periosteal perimeter1.93.23.51.9-1.7
Bone: post-yield work0.00.00.10.2-0.2
Progressive ratio test 1 active lever presses0.10.10.2-0.20.4
Progressive ratio test 1 breakpoint0.10.10.2-0.20.5
Progressive ratio test 1 inactive lever presses1.82.62.7-1.61.6
Progressive ratio test 2 active lever presses0.10.10.10.2-0.3
Progressive ratio test 2 breakpoint0.10.10.10.2-0.3
Progressive ratio test 2 inactive lever presses0.20.30.3-0.50.5
Incentive Sensitization - Responses0.10.10.10.2-0.3
Incentive Sensitization - Breakpoint0.00.00.00.1-0.2
Sum of active levers in priming session hrs 5-60.00.00.00.2-0.2
Progressive ratio0.91.51.6-1.21.3
Food seeking constrained by brief footshock0.20.30.30.5-0.6
Seeking ratio, punishment vs. effort4.26.06.22.4-2.5
Retroperitoneal fat weight0.00.20.2-0.40.4
Reaction time number correct0.91.72.01.1-1.4
Reaction time mean minus median0.00.00.10.3-0.1
Reaction time mean minus median AUC0.10.10.2-0.30.4
Reaction time num false alarms0.50.80.8-0.80.9
Reaction time num false alarms AUC0.20.20.3-0.50.5
Reaction time trials correct on left0.91.72.01.1-1.4
Reaction time trials on left1.01.92.31.2-1.5
Reaction time mean1.42.22.3-1.51.5
Reaction time mean AUC0.91.51.5-1.21.2
Median of all reaction times3.34.74.9-2.22.1
Reaction time omissions0.30.50.50.7-0.7
Reaction time false alarm rate1.21.61.8-1.21.3
Reaction time premature initiation rate1.92.72.91.7-1.6
Reaction time premature initiations2.34.14.12.0-2.0
Std. dev. reaction times0.20.50.5-0.60.7
Reaction time trials completed1.01.92.31.2-1.5
Reaction time trials AUC0.81.51.81.1-1.4
Run reversals in cocaine runway, females0.00.00.0-0.10.0
Run reversals in cocaine runway, males0.10.10.10.3-0.2
Latency to leave start box in cocaine runway1.71.92.01.4-1.3
Latency to leave start box in cocaine runway, F0.50.60.60.7-0.8
Latency to leave start box in cocaine runway, M4.84.54.72.2-2.1
Std. dev. time between licks in bursts0.50.70.70.8-0.8
Total sessions with >9 infusions0.10.10.20.00.4
Short access day 1 total inactive lever presses0.50.60.7-0.80.8
Short access day 10 total inactive lever presses0.71.82.3-1.51.1
Short access day 1 total infusions0.20.20.3-0.30.6
Short access day 10 total infusions0.70.91.0-0.91.0
Short access total infusions0.30.40.5-0.40.7
Short access day 1 locomotion0.00.00.1-0.00.3
Short access day 10 total locomotion0.10.20.3-0.60.4
Short access total locomotion0.20.30.4-0.40.6
One hour access (0.3 mA shock)0.50.60.60.7-0.8
Compulsive drug intake1.61.92.11.3-1.4
One hour access (shock baseline)0.30.40.4-0.60.7
Social response proportion0.30.30.3-0.60.6
Social responses0.00.00.00.2-0.2
Social time0.10.10.1-0.30.4
Soleus weight17.050.251.17.0-7.1
Bone: stiffness0.60.91.11.1-0.9
Tibialis anterior weight14.248.149.27.0-6.9
Time to tail flick, vehicle, before self-admin0.10.10.1-0.30.3
Time to tail flick, vehicle, after self-admin2.12.83.2-1.81.5
Time to tail flick, test, before self-admin1.41.51.5-1.21.2
Time to tail flick, test, after self-admin3.94.14.5-1.92.1
Delta time to tail flick, vehicle, before/after SA1.71.61.9-1.41.2
Delta time to tail flick, test, before/after SA0.00.00.0-0.00.1
Tibia length0.10.20.2-0.40.4
Ambulatory time before self-admin0.20.30.3-0.60.4
Ambulatory time after self-admin0.40.50.50.7-0.7
Bone: tissue strength1.51.51.6-1.21.3
Total heroin consumption1.01.21.31.1-1.0
Bone: trabecular number1.21.92.1-1.41.3
Bone: trabecular spacing0.00.00.00.2-0.2
Bone: trabecular thickness0.50.60.7-0.80.7
Bone: trabecular tissue density4.97.27.42.7-2.7
Water consumed over 24 hours0.30.50.5-0.60.7
Number of responses in last shaping day0.00.10.1-0.20.3