Wdr74

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	intron excision ratio	chr1_205632316_205633678	0.04	0.03	8.1e-03	0.02	0.01	0	0.01	2.5e-02	7.8e-02	2.2e-01	1.2e-01
2	NAcc	gene expression	Wdr74	0.06	0.04	1.5e-03	0.01	0.02	0.01	0.02	1.5e-02	3.0e-03	6.4e-03	3.1e-03
3	Adipose	gene expression	Wdr74	0.08	0.06	1.3e-03	0.03	0.01	0.01	0.03	2.4e-04	1.1e-02	1.8e-02	6.3e-04
4	PL	gene expression	Wdr74	0.08	0.05	8.6e-05	0.04	0.03	0.04	0.04	4.6e-05	1.3e-04	5.2e-05	4.9e-05
5	Brain	gene expression	Wdr74	0.14	0.07	4.7e-07	0.08	0.06	0.07	0.08	2.9e-08	1.2e-06	4.6e-07	1.0e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.9	1.5	2.0	0.5	1.3	-1.4	-1.4	-1.3
Area under the delay curve	0.6	0.6	0.9	-0.0	0.9	-0.8	-0.8	-0.9
BMI with tail	4.6	15.0	17.8	2.8	3.8	-4.2	-4.2	-4.1
BMI without tail	1.4	2.9	3.6	1.5	1.5	-1.9	-1.9	-1.7
Body weight	2.3	9.6	17.9	4.2	2.0	-3.0	-3.0	-2.9
Weight adjusted by age	0.9	1.0	2.3	1.5	0.7	-0.9	-0.9	-0.9
Bone surface	1.7	3.0	3.2	1.8	1.6	-1.8	-1.8	-1.7
Bone volume	1.2	2.0	2.5	1.1	1.5	-1.5	-1.6	-1.4
Breakpoint value in progressive ratio session	0.8	0.8	2.6	1.6	-0.9	0.5	0.5	0.5
Number of licking bursts	0.0	0.0	0.0	0.1	0.1	-0.1	-0.2	-0.0
Context. condit. distance diff. score	0.7	0.8	0.9	-0.9	1.0	-0.9	-0.9	-0.9
Locomotion velocity, session 1	0.2	0.3	0.4	-0.2	0.4	-0.6	-0.5	-0.7
Locomotion distance, session 1	1.2	1.5	2.1	0.5	1.1	-1.4	-1.4	-1.4
Locomotion velocity, session 2	1.2	1.4	3.1	1.8	0.7	-1.0	-1.1	-1.1
Locomotion distance, session 2	0.1	0.1	0.2	0.3	0.2	-0.4	-0.4	-0.4
Locomotion velocity, session 3	2.9	3.4	5.0	0.5	2.0	-2.1	-2.2	-1.9
Locomotion distance, session 3	0.1	0.1	0.3	0.3	0.2	-0.3	-0.6	-0.2
Stereotopy head waving bouts, day 3	2.7	3.2	4.7	-0.5	2.2	-1.9	-1.9	-1.9
Stereotopy head waving duration, day 3	1.2	1.4	2.0	-0.6	1.4	-1.2	-1.3	-1.2
Locomotion velocity, session 7	0.5	0.6	1.0	-0.3	1.0	-0.7	-0.9	-0.8
Locomotion distance, session 7	0.7	0.8	1.0	-0.5	1.0	-1.0	-1.0	-1.0
Stereotopy head waving bouts, day 7	0.3	0.3	0.5	0.3	0.7	-0.5	-0.6	-0.5
Stereotopy head waving duration, day 7	0.9	1.1	2.7	1.6	0.6	-0.8	-1.0	-0.9
Locomotion velocity, session 8	0.1	0.1	0.2	-0.4	-0.3	0.2	0.2	0.1
Locomotion distance, session 8	1.0	1.5	2.0	-0.8	1.4	-1.3	-1.3	-1.3
Degree of sensitization distance	2.3	2.3	3.2	-0.4	1.8	-1.7	-1.5	-1.8
Degree of sensitization stereotypy	0.3	0.3	1.2	1.1	0.3	-0.3	-0.4	-0.3
Conditioned locomotion	0.2	0.2	0.6	0.8	0.2	-0.3	-0.4	-0.3
Cocaine response after cond. corrected	0.4	0.4	1.5	-1.2	0.4	-0.4	-0.3	-0.4
Cocaine response after cond. not corrected	0.3	0.3	1.1	-1.0	0.4	-0.4	-0.3	-0.4
Cocaine response before conditioning	0.2	0.2	0.7	0.8	-0.4	0.3	0.4	0.3
Saline control response	0.7	0.9	3.9	2.0	-0.1	-0.5	-0.5	-0.4
Bone: connectivity density	1.8	2.9	3.5	1.6	1.5	-1.8	-1.9	-1.7
Bone: cortical apparent density	0.4	0.6	0.8	0.7	-0.9	0.7	0.7	0.8
Bone: cortical area	0.5	0.8	1.6	1.3	0.7	-0.8	-0.8	-0.8
Bone: cortical porosity	0.6	0.6	1.0	-0.3	-0.8	0.9	1.0	0.8
Bone: cortical porosity	0.6	0.7	1.0	0.0	-1.0	0.9	1.0	0.8
Bone: cortical thickness	0.9	1.5	5.7	2.4	-1.1	0.4	0.4	0.4
Bone: cortical thickness	0.3	0.4	0.6	0.7	-0.8	0.5	0.4	0.5
Bone: cortical tissue density	0.5	0.7	1.0	0.8	-1.0	0.8	0.8	0.8
Condit. Reinf. active minus inactive responses	0.3	0.4	1.2	1.1	0.2	-0.5	-0.4	-0.4
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.4	0.6	-0.5	0.2	0.3	0.3
Condit. Reinf. active responses	0.7	0.9	1.2	1.1	0.9	-1.0	-0.8	-1.0
Condit. Reinf. inactive responses	0.7	0.9	1.4	0.1	1.2	-0.9	-0.9	-1.1
Incentive salience index mean	1.1	1.4	1.7	1.3	0.9	-1.3	-1.1	-1.2
Condit. Reinf. lever presses	1.4	1.8	2.3	1.1	1.3	-1.5	-1.4	-1.5
Condit. Reinf. active minus inactive responses	0.3	0.3	0.7	-0.5	-0.3	0.6	0.6	0.8
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.6	-0.8	0.7	-0.1	-0.2	0.0
Condit. Reinf. active responses	0.1	0.1	0.2	0.2	-0.3	0.3	0.3	0.4
Condit. Reinf. inactive responses	0.2	0.2	0.5	0.4	-0.7	0.3	0.4	0.3
Condit. Reinf. lever presses	0.3	0.5	1.6	1.3	0.3	-0.5	-0.4	-0.4
Condit. Reinf. lever reinforcers received	0.1	0.2	0.3	0.5	-0.4	0.4	0.4	0.5
Conditioned reinforcement - actives	0.9	0.9	2.2	-1.5	-0.3	0.9	0.9	0.7
Conditioned reinforcement - inactives	0.4	0.4	0.9	-0.9	0.9	-0.3	-0.3	-0.5
Conditioned locomotion	0.8	0.9	2.4	-1.5	1.2	-0.5	-0.4	-0.6
Patch foraging indifference point 0 sec	0.2	0.3	0.8	0.9	0.3	-0.6	-0.5	-0.5
Patch foraging indifference point AUC	0.6	0.6	3.1	1.8	-0.2	0.0	0.1	0.2
Delay disc. indifference point, 0s delay	1.3	1.5	2.0	-0.7	1.4	-1.3	-1.3	-1.3
Delay disc. indifference point, 16s delay	0.7	0.7	1.0	0.3	1.0	-0.9	-0.9	-0.9
Delay disc. indifference point, 2s delay	0.7	0.8	1.3	-0.5	1.1	-0.9	-0.9	-0.9
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	0.3	0.2	-0.4	-0.4	-0.4
Delay disc. indifference point, 4s delay	0.9	0.9	1.5	0.3	0.9	-1.1	-1.1	-1.2
Delay disc. indifference point, 8s delay	0.1	0.1	0.4	-0.7	0.1	-0.1	-0.1	-0.1
Indifference point function ln k	1.2	1.6	6.1	-2.5	0.8	-0.6	-0.6	-0.8
Indifference point function log k	1.2	1.6	6.1	-2.5	0.8	-0.6	-0.6	-0.8
Patch foraging total patch changes 0 sec	0.1	0.2	0.8	0.9	-0.1	-0.3	-0.2	-0.2
Patch foraging total patch changes 12 sec	1.4	1.8	8.8	3.0	-0.2	-0.3	-0.2	-0.2
Patch foraging total patch changes 18 sec	0.3	0.3	0.5	0.7	-0.5	0.4	0.6	0.6
Patch foraging total patch changes 24 sec	2.7	3.3	9.4	3.1	0.8	-1.5	-1.4	-1.4
Patch foraging total patch changes 6 sec	0.5	0.7	1.7	1.3	0.5	-0.8	-0.8	-0.7
Patch foraging time to switch 0 sec	0.8	1.3	2.0	0.6	1.4	-1.1	-1.2	-1.2
Patch foraging water rate 0 sec	0.4	0.6	0.7	-0.8	-0.8	0.7	0.8	0.8
Patch foraging water rate 12 sec	0.5	0.7	2.5	-1.6	-0.7	0.4	0.6	0.5
Patch foraging water rate 18 sec	0.3	0.4	1.0	-1.0	0.3	-0.6	-0.6	-0.6
Patch foraging water rate 24 sec	0.5	0.6	2.2	-1.5	-0.4	0.5	0.6	0.4
Patch foraging water rate 6 sec	0.4	0.5	1.8	-1.3	-0.6	0.4	0.5	0.3
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.2	-0.0	0.3	-0.2	-0.3	-0.4
Distance traveled before self-admin	0.6	0.7	2.8	1.7	0.2	-0.4	-0.4	-0.4
Distance traveled after self-admin	0.2	0.2	0.4	0.7	-0.5	0.4	0.4	0.4
Extensor digitorum longus weight	2.9	11.5	29.8	5.5	1.7	-3.0	-2.9	-2.8
Bone: elastic displacement	1.0	1.1	1.3	-0.8	-1.1	1.1	1.1	1.2
Bone: elastic work	0.1	0.2	0.8	0.9	-0.4	0.0	-0.0	0.1
Bone: endosteal estimation	2.2	4.8	8.0	-1.6	2.8	-2.2	-2.1	-2.0
Bone: endosteal perimeter	2.0	4.2	7.5	-1.8	2.7	-1.9	-1.8	-1.9
Epididymis fat weight	0.8	1.9	2.8	-0.6	1.7	-1.5	-1.5	-1.4
Delta time in closed arm before/after self-admin	1.2	1.1	1.5	1.0	0.7	-1.2	-1.2	-1.2
Delta time in open arm before/after self-admin	0.4	0.3	1.7	1.3	0.0	-0.1	-0.1	-0.1
Diff in mean of infusions in LGA sessions	0.9	1.0	2.0	1.4	-1.2	0.7	0.7	0.7
Delay discount exponential model param	0.5	0.5	0.7	0.0	-0.8	0.8	0.8	0.9
Extinction: sum of active levers before priming	1.1	1.1	4.5	2.1	0.1	-0.6	-0.6	-0.6
Active lever presses in extinction session 6	0.8	0.7	3.1	1.8	-0.6	0.3	0.3	0.2
Bone: final force	1.6	2.6	3.6	1.9	1.3	-1.6	-1.6	-1.6
Bone: final moment	1.5	2.4	3.5	1.9	1.3	-1.5	-1.5	-1.5
Food consumed during 24 hour testing period	0.2	0.2	0.4	-0.1	-0.3	0.4	0.4	0.7
Glucose	0.8	1.2	4.1	-2.0	1.1	-0.5	-0.6	-0.5
Heart weight	0.6	0.8	1.5	-1.2	0.9	-0.7	-0.8	-0.8
Delay discount hyperbolic model param	0.6	0.6	0.9	0.0	-0.9	0.9	0.9	0.9
Intermittent access intake day 1-15 change	2.1	2.1	2.7	-1.2	-1.2	1.6	1.5	1.6
Intermittent access intake escalation	1.5	1.5	2.0	-0.9	-1.1	1.4	1.3	1.4
Intermittent access intake escalation 2	0.7	0.7	0.9	-0.1	-0.9	0.9	0.9	0.9
Intermitt. access day 1 inactive lever presses	0.4	0.5	2.1	-1.5	0.5	0.2	0.1	0.1
Intermitt. access day 15 inactive lever presses	1.2	1.3	2.3	0.3	1.5	-1.2	-1.2	-1.2
Intermitt. access escalation Index	0.3	0.2	0.3	-0.5	0.6	-0.4	-0.5	-0.4
Intermittent access day 1 total infusions	4.3	4.9	9.4	-0.9	3.1	-2.2	-2.2	-2.2
Intermittent access day 15 total infusions	1.0	1.2	3.8	-1.9	1.3	-0.3	-0.3	-0.3
Intermittent access terminal intake (last 3 days)	1.6	1.8	4.0	-0.7	2.0	-1.2	-1.2	-1.2
Intermittent access total infusions	1.8	2.0	4.2	-1.0	2.1	-1.2	-1.2	-1.3
Intermittent access day 1 locomotion	5.6	5.8	10.0	-0.4	3.2	-2.5	-2.5	-2.6
Intermittent access day 15 total locomotion	1.6	1.7	3.4	-0.3	1.8	-1.3	-1.2	-1.4
Intermittent access total locomotion	5.6	6.4	11.8	-0.2	3.4	-2.6	-2.5	-2.7
Intermittent access standard deviation	1.3	1.4	1.7	-1.2	-0.9	1.3	1.3	1.2
Left kidney weight	0.3	0.7	1.0	0.3	1.0	-1.0	-1.0	-0.8
Right kidney weight	0.4	1.0	1.4	0.5	1.2	-1.0	-1.0	-1.1
Cocaine induced anxiety	0.1	0.1	0.3	0.5	0.2	-0.2	-0.2	-0.2
Post-drug Anxiety	0.1	0.2	0.8	0.9	-0.1	-0.0	-0.0	0.0
Baseline Anxiety	0.3	0.3	1.2	1.1	-0.4	-0.1	-0.1	-0.1
Tail length	0.4	1.2	3.0	1.7	-1.3	0.6	0.6	0.6
Length with tail	0.7	2.4	10.3	3.2	-0.1	-0.8	-0.7	-0.8
Length without tail	0.8	1.8	5.4	2.3	0.6	-1.1	-0.9	-1.1
Times rat made contact with spout	0.3	0.3	0.7	0.3	-0.8	0.6	0.5	0.6
Lifetime Intake	1.7	2.0	3.9	-1.0	2.0	-1.3	-1.2	-1.3
Liver weight, left	0.1	0.2	0.5	-0.7	-0.3	0.4	0.5	0.4
Liver weight, right	0.5	0.8	1.1	0.0	1.0	-1.0	-0.9	-1.1
Locomotor activity	0.4	0.7	1.2	-1.1	-0.9	0.7	0.6	0.7
Locomotor testing distance	0.3	0.4	1.7	-1.3	-0.5	0.3	0.1	0.3
Locomotor testing rearing	0.3	0.5	1.7	-1.3	-0.4	0.4	0.3	0.4
Locomotion in novel chamber	0.5	0.6	2.3	-1.5	0.9	-0.1	-0.1	-0.2
Locomotion in novel chamber post-restriction	0.9	1.1	3.7	-1.9	-0.2	0.8	0.8	0.9
Fecal boli incidents, locomotor time 1	0.1	0.1	0.2	-0.4	0.1	0.4	0.4	0.3
Change in fecal boli incidents, locomotor task	0.4	0.3	0.9	-1.0	0.4	-0.5	-0.5	-0.4
Time >=10cm from walls, locomotor time 1	0.7	0.7	1.9	-1.4	1.1	-0.2	-0.2	-0.3
Bouts of movement, locomotor time 1	3.5	3.8	5.5	0.5	-2.3	2.2	2.2	2.0
Total resting periods, locomotor time 1	2.3	2.5	3.5	0.5	-1.9	1.7	1.7	1.7
Rest time, locomotor task time 1	1.2	1.3	1.8	-1.4	-0.9	1.2	1.2	1.1
Distance moved, locomotor task time 1	0.5	0.6	0.6	0.6	0.7	-0.8	-0.8	-0.8
Vertical activity count, locomotor time 1	0.1	0.1	0.6	-0.8	0.2	0.0	0.0	0.0
Time >=10cm from walls, locomotor time 2	0.4	0.5	0.7	-0.2	-0.5	0.8	0.8	0.7
Bouts of movement, locomotor time 2	0.3	0.4	1.5	1.2	-0.5	0.2	0.2	0.0
Total resting periods, locomotor time 2	0.2	0.2	0.7	0.8	-0.4	0.2	0.2	0.0
Rest time, locomotor task time 2	1.0	1.2	4.5	-2.1	-0.1	0.7	0.7	0.7
Distance moved, locomotor task time 2	0.5	0.5	0.8	0.8	-0.9	0.6	0.6	0.6
Vertical activity count, locomotor time 2	1.1	1.2	2.0	-0.1	-1.4	1.1	1.1	1.1
Light reinforcement 1	0.4	0.8	1.2	-0.3	-0.9	0.9	1.1	0.9
Light reinforcement 2	0.1	0.1	0.5	-0.3	0.7	-0.2	-0.1	-0.2
Bone: marrow area	2.2	4.7	7.7	-1.7	2.8	-2.1	-2.1	-2.0
Bone: maximum diameter	0.6	1.1	1.7	0.5	1.3	-1.1	-1.0	-1.1
Bone: maximum force	3.7	6.5	7.2	2.2	2.5	-2.7	-2.7	-2.6
Bone: maximum moment	3.4	5.8	6.5	2.2	2.3	-2.5	-2.5	-2.5
Mean time between licks in bursts	0.3	0.5	0.9	0.9	-0.0	-0.7	-0.7	-0.8
Mean num. licks in bursts	0.3	0.4	0.6	-0.2	-0.7	0.7	0.7	0.6
Cd content in liver	0.5	0.5	1.9	-1.4	-0.0	0.4	0.4	0.4
Co content in liver	3.6	4.2	4.8	-1.6	-2.1	2.2	2.2	2.1
Cu content in liver	0.1	0.1	0.2	0.4	-0.4	0.1	0.1	0.1
Fe content in liver	0.0	0.0	0.0	-0.1	0.2	-0.1	-0.0	-0.1
K content in liver	2.1	2.0	2.5	1.2	1.4	-1.6	-1.5	-1.4
Mg content in liver	2.4	2.5	3.2	0.7	1.7	-1.8	-1.8	-1.6
Mn content in liver	0.8	0.9	3.3	1.8	0.3	-0.7	-0.7	-0.5
Na content in liver	0.4	0.4	0.9	0.9	0.5	-0.6	-0.6	-0.4
Rb content in liver	0.4	0.5	1.9	-1.4	0.5	-0.4	-0.4	-0.2
Se content in liver	0.3	0.4	0.5	0.6	0.7	-0.6	-0.6	-0.4
Sr content in liver	1.3	1.2	5.9	2.4	-0.2	-0.1	-0.1	-0.2
Zn content in liver	1.5	1.6	4.9	2.2	0.7	-1.0	-1.0	-0.9
Bone: minimum diameter	2.1	4.0	6.6	-0.9	2.6	-2.1	-2.1	-2.0
Time in familiar zone, hab. session 1	0.4	0.4	0.6	0.3	0.6	-0.7	-0.7	-0.7
Time in novel zone, hab. session 1	0.8	0.8	1.5	-1.2	-0.6	0.7	0.7	0.9
Total zone transitions, hab. session 1	0.0	0.1	0.3	0.5	-0.1	-0.1	0.1	-0.1
Total locomotion distance, hab. session 1	0.5	0.7	1.2	-0.4	1.1	-0.9	-0.8	-0.9
Locomotion velocity, hab. session 1	0.3	0.4	0.6	0.2	0.8	-0.7	-0.6	-0.7
Time in familiar zone, hab. session 2	1.0	1.0	1.5	-0.3	-1.2	1.0	1.0	1.2
Time in novel zone, hab. session 2	1.3	1.3	1.8	0.6	1.2	-1.2	-1.3	-1.3
Total zone transitions, hab. session 2	1.3	1.6	2.1	1.3	0.9	-1.3	-1.5	-1.3
Total locomotion distance, hab. session 2	0.9	1.1	1.7	0.2	1.1	-1.2	-1.3	-1.2
Locomotion velocity, hab. session 2	1.0	1.3	1.7	0.1	1.3	-1.3	-1.3	-1.3
Novel to familiar place preference ratio	0.9	1.0	2.6	1.6	0.6	-0.8	-0.8	-0.8
Novelty place preference	0.6	0.6	1.6	1.3	0.5	-0.6	-0.6	-0.7
Time in novel zone, NPP test	0.7	0.7	1.7	1.3	0.6	-0.7	-0.7	-0.7
Total zone transitions, NPP test	0.4	0.6	1.2	1.1	0.3	-0.6	-0.8	-0.7
Total locomotion distance, NPP test	0.3	0.4	0.6	-0.0	0.7	-0.7	-0.8	-0.6
Locomotion velocity, NPP test	0.1	0.1	0.2	-0.1	0.4	-0.3	-0.4	-0.3
Intraocular pressure	0.6	0.8	1.1	-0.2	-1.0	1.0	1.0	1.0
Delta distance traveled before/after self-admin	0.3	0.3	0.6	-0.8	-0.6	0.5	0.5	0.5
Delta ambulatory time before/after self-admin	0.6	0.7	1.1	-1.0	-0.8	0.7	0.7	0.7
Parametrial fat weight	0.8	1.6	2.7	-1.6	1.6	-0.8	-0.9	-1.0
Pavlov. Cond. lever latency	1.6	2.0	2.5	-1.3	-1.3	1.6	1.3	1.6
Pavlov. Cond. magazine entry latency	1.0	1.3	1.6	1.3	1.1	-1.1	-1.1	-1.1
Pavlov. Cond. change in total contacts	0.3	0.4	0.6	0.6	0.8	-0.6	-0.5	-0.5
Pavlov. Cond. index score	0.3	0.4	0.9	1.0	0.5	-0.5	-0.4	-0.4
Pavlov. Cond. latency score	0.4	0.5	0.8	0.9	0.7	-0.7	-0.6	-0.7
Pavlov. Cond. lever contacts	0.5	0.6	0.7	0.6	0.8	-0.9	-0.8	-0.8
Pavlov. Cond. magazine entry number	0.2	0.2	1.0	-1.0	0.1	-0.1	-0.2	-0.2
Pavlov. Cond. intertrial magazine entries	0.5	0.6	0.9	0.1	-0.8	0.9	1.0	0.9
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	1.2	1.1	0.5	-0.5	-0.5	-0.5
Pavlov. Cond. response bias	0.3	0.4	1.1	1.0	0.5	-0.5	-0.4	-0.4
Pavlov. Cond. lever latency	0.5	0.7	0.8	-0.8	-0.8	0.9	0.9	0.9
Pavlov. Cond. magazine entry latency	1.0	1.2	5.6	2.4	-0.2	-0.3	-0.3	-0.4
Pavlov. Cond. change in total contacts	0.4	0.6	2.6	1.6	0.3	-0.4	-0.4	-0.3
Pavlov. Cond. index score	0.9	1.1	4.0	2.0	0.4	-0.7	-0.7	-0.7
Pavlov. Cond. latency score	0.9	1.2	3.4	1.9	0.6	-0.8	-0.8	-0.8
Pavlov. Cond. lever contacts	0.1	0.1	0.6	0.8	-0.1	0.0	-0.0	0.0
Pavlov. Cond. magazine entry number	1.9	2.3	10.0	-3.2	-0.2	0.7	0.7	0.7
Pavlov. Cond. intertrial magazine entries	0.8	1.1	2.4	-1.6	-0.5	0.9	1.0	0.9
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.2	4.5	2.1	0.3	-0.6	-0.7	-0.7
Pavlov. Cond. response bias	0.4	0.6	2.7	1.6	0.0	-0.3	-0.3	-0.3
Time in closed arm before self-admin	0.0	0.0	0.1	0.0	0.2	-0.0	-0.0	0.0
Time in closed arm after self-admin	0.1	0.1	0.6	-0.8	0.3	-0.2	-0.2	-0.2
Time in open arm before self-admin	0.4	0.4	1.2	-1.1	-0.6	0.5	0.5	0.3
Time in open arm after self-admin	0.6	0.7	1.2	0.1	-1.1	0.9	0.9	0.9
Bone: periosteal estimation	1.5	3.2	5.3	-0.1	2.3	-1.9	-1.9	-1.8
Bone: periosteal perimeter	0.6	1.1	1.9	0.0	1.4	-1.0	-1.0	-1.1
Bone: post-yield work	3.8	5.2	8.8	-0.5	3.0	-2.4	-2.4	-2.4
Progressive ratio test 1 active lever presses	0.5	0.5	2.4	-1.5	0.3	0.3	0.4	0.2
Progressive ratio test 1 breakpoint	0.6	0.7	2.7	-1.6	0.2	0.4	0.5	0.4
Progressive ratio test 1 inactive lever presses	0.5	0.6	0.9	0.1	0.9	-0.8	-0.8	-1.0
Progressive ratio test 2 active lever presses	0.6	0.7	1.8	-1.3	1.1	-0.3	-0.2	-0.4
Progressive ratio test 2 breakpoint	0.6	0.7	3.1	-1.8	0.6	0.2	0.3	0.2
Progressive ratio test 2 inactive lever presses	1.0	1.2	2.6	-0.8	1.6	-0.9	-0.9	-1.0
Incentive Sensitization - Responses	0.7	0.7	1.2	0.3	1.1	-0.9	-0.8	-0.9
Incentive Sensitization - Breakpoint	0.7	0.8	1.3	0.2	1.2	-0.9	-0.8	-1.0
Sum of active levers in priming session hrs 5-6	1.3	1.2	1.4	1.2	-1.2	1.1	1.1	1.0
Progressive ratio	0.3	0.4	0.6	0.3	0.8	-0.7	-0.7	-0.6
Food seeking constrained by brief footshock	0.0	0.0	0.1	-0.4	-0.2	0.2	0.0	0.2
Seeking ratio, punishment vs. effort	0.2	0.2	0.3	-0.5	-0.6	0.5	0.4	0.4
Retroperitoneal fat weight	0.8	2.7	8.0	-2.8	1.7	-1.0	-0.9	-0.9
Reaction time number correct	0.2	0.3	1.2	1.1	-0.5	-0.1	-0.2	-0.0
Reaction time mean minus median	0.6	0.8	1.3	0.7	-0.8	1.1	1.1	0.8
Reaction time mean minus median AUC	1.4	1.9	2.9	0.4	-1.4	1.6	1.7	1.3
Reaction time num false alarms	0.4	0.5	0.9	-0.7	-0.9	0.6	0.6	0.8
Reaction time num false alarms AUC	0.4	0.6	1.3	-0.2	-1.1	0.7	0.7	0.8
Reaction time trials correct on left	0.2	0.3	1.2	1.1	-0.5	-0.1	-0.2	-0.0
Reaction time trials on left	0.2	0.3	1.2	1.1	-0.6	0.0	-0.1	0.1
Reaction time mean	0.5	0.7	1.1	-0.3	-0.7	1.1	1.0	0.9
Reaction time mean AUC	0.5	0.7	1.1	-0.3	-0.7	1.1	1.0	0.9
Median of all reaction times	0.1	0.1	0.2	-0.1	-0.2	0.4	0.3	0.4
Reaction time omissions	1.2	1.7	2.4	0.1	-1.5	1.5	1.5	1.3
Reaction time false alarm rate	0.2	0.3	0.6	-0.8	-0.5	0.4	0.4	0.5
Reaction time premature initiation rate	2.2	3.0	5.9	2.4	0.8	-1.8	-1.6	-1.6
Reaction time premature initiations	1.8	2.5	8.5	2.9	0.0	-1.3	-1.2	-1.0
Std. dev. reaction times	1.6	2.3	3.4	-0.3	-1.5	1.8	1.8	1.6
Reaction time trials completed	0.2	0.3	1.2	1.1	-0.6	0.0	-0.1	0.1
Reaction time trials AUC	0.2	0.2	0.9	1.0	-0.4	-0.1	-0.2	-0.0
Run reversals in cocaine runway, females	2.7	2.6	3.4	0.8	1.6	-1.9	-1.8	-1.8
Run reversals in cocaine runway, males	0.5	0.5	0.7	-0.8	-0.6	0.8	0.6	0.8
Latency to leave start box in cocaine runway	0.9	1.0	1.6	-0.6	1.3	-1.1	-0.9	-1.1
Latency to leave start box in cocaine runway, F	0.2	0.2	0.3	0.1	0.5	-0.5	-0.4	-0.5
Latency to leave start box in cocaine runway, M	0.8	0.7	3.5	-1.9	0.4	-0.1	0.1	-0.1
Std. dev. time between licks in bursts	0.0	0.0	0.1	-0.4	-0.2	-0.1	-0.1	-0.2
Total sessions with >9 infusions	1.4	1.5	2.5	-1.5	1.6	-0.9	-0.9	-1.0
Short access day 1 total inactive lever presses	1.1	1.3	2.3	-1.0	1.5	-1.0	-1.0	-1.1
Short access day 10 total inactive lever presses	0.6	0.6	2.8	-1.7	0.1	0.4	0.4	0.3
Short access day 1 total infusions	1.0	1.0	1.8	-1.1	1.3	-0.8	-0.9	-0.9
Short access day 10 total infusions	3.6	4.0	6.9	-0.5	2.6	-2.1	-2.0	-2.1
Short access total infusions	2.0	2.2	3.8	-0.8	2.0	-1.5	-1.5	-1.6
Short access day 1 locomotion	3.1	3.3	5.1	0.1	2.3	-1.9	-2.0	-2.0
Short access day 10 total locomotion	2.2	2.5	4.0	0.0	2.0	-1.6	-1.6	-1.8
Short access total locomotion	3.9	4.1	6.1	0.3	2.5	-2.2	-2.1	-2.2
One hour access (0.3 mA shock)	1.1	1.2	4.9	-2.2	1.1	-0.1	-0.1	-0.1
Compulsive drug intake	0.8	0.8	1.9	1.0	-1.4	0.5	0.5	0.6
One hour access (shock baseline)	1.2	1.4	6.1	-2.5	0.9	0.4	0.4	0.3
Social response proportion	0.1	0.1	0.2	0.5	0.0	-0.2	-0.1	-0.2
Social responses	0.7	0.8	1.4	0.3	-1.2	1.0	0.9	1.0
Social time	0.5	0.7	1.2	-0.1	-1.1	0.9	0.9	0.8
Soleus weight	0.7	2.1	9.2	-3.0	-0.0	0.6	0.5	0.7
Bone: stiffness	0.8	1.3	1.6	1.3	1.1	-1.2	-1.1	-1.1
Tibialis anterior weight	2.9	9.8	37.7	6.1	0.7	-1.9	-1.9	-1.9
Time to tail flick, vehicle, before self-admin	2.2	2.2	3.0	0.7	1.7	-1.6	-1.6	-1.6
Time to tail flick, vehicle, after self-admin	0.9	0.9	1.2	0.6	0.9	-1.1	-1.1	-1.0
Time to tail flick, test, before self-admin	3.1	3.0	3.8	0.4	1.9	-1.9	-1.9	-1.9
Time to tail flick, test, after self-admin	0.1	0.1	0.1	-0.3	-0.3	0.3	0.3	0.2
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.0	-0.0	-0.2	0.1	0.1	0.1
Delta time to tail flick, test, before/after SA	3.0	2.7	3.7	-0.1	-1.9	1.8	1.8	1.8
Tibia length	0.6	1.6	5.4	2.3	0.9	-0.9	-0.8	-0.8
Ambulatory time before self-admin	0.5	0.5	2.5	1.6	-0.0	-0.1	-0.1	-0.1
Ambulatory time after self-admin	0.1	0.1	0.3	0.6	0.3	-0.2	-0.2	-0.2
Bone: tissue strength	0.0	0.0	0.1	-0.2	-0.3	0.2	0.2	0.1
Total heroin consumption	1.3	1.6	4.7	2.2	-1.4	0.7	0.7	0.6
Bone: trabecular number	1.4	2.3	3.1	1.0	1.5	-1.7	-1.7	-1.5
Bone: trabecular spacing	1.1	1.4	1.8	-0.5	-1.3	1.3	1.3	1.2
Bone: trabecular thickness	0.1	0.1	0.3	-0.6	0.4	-0.0	-0.1	-0.0
Bone: trabecular tissue density	2.5	3.6	7.4	-2.7	-1.2	1.8	1.9	1.5
Water consumed over 24 hours	0.3	0.3	0.6	0.8	-0.7	0.3	0.3	0.5
Number of responses in last shaping day	0.0	0.0	0.0	-0.2	0.0	-0.1	-0.1	-0.2