Hub : Genes

Aip

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression Aip 0.09 0.07 5.4e-03 0.04 0.03 0.01 0.03 3.1e-03 1.6e-02 7.0e-02 1.1e-02
2 NAcc gene expression Aip 0.11 0.08 4.1e-08 0.04 0.05 0.04 0.04 1.9e-06 1.1e-07 2.0e-06 1.4e-06
3 IL gene expression Aip 0.34 0.18 3.1e-03 0.03 0.07 0.05 0.04 5.7e-02 1.0e-02 2.2e-02 3.4e-02
4 Brain gene expression Aip 0.13 0.08 3.0e-05 0.01 0.04 0.04 0.04 1.5e-02 4.7e-05 6.0e-05 9.8e-05
5 pVTA gene expression Aip 0.12 0.08 1.7e-04 0.02 0.03 0.03 0.02 1.5e-02 1.4e-03 2.3e-03 5.7e-03
6 PL gene expression Aip 0.11 0.08 9.2e-06 0.01 0.04 0.04 0.04 1.6e-02 3.5e-05 1.9e-05 5.9e-05
7 Adipose mRNA stability Aip 0.08 0.06 3.3e-05 0.04 0.04 0.03 0.04 3.7e-05 8.1e-05 2.2e-04 7.4e-05
8 Adipose gene expression Aip 0.43 0.16 0.0e+00 0.23 0.23 0.23 0.24 1.4e-25 3.2e-25 1.3e-25 6.4e-26

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density2.54.67.4-0.71.92.02.32.3-1.9-2.72.6
Area under the delay curve0.50.81.4-0.10.60.70.80.9-1.1-1.21.1
BMI with tail3.411.816.0-2.03.43.53.63.6-4.0-3.53.5
BMI without tail1.05.46.3-2.12.52.52.42.4-2.5-2.12.1
Body weight2.511.114.9-3.63.93.83.53.4-3.4-2.52.4
Weight adjusted by age0.20.61.0-1.01.00.90.80.7-0.6-0.20.2
Bone surface4.69.110.6-2.03.13.23.33.3-3.0-3.13.0
Bone volume2.24.46.1-0.92.02.12.22.3-2.0-2.52.4
Breakpoint value in progressive ratio session1.12.03.2-1.81.61.61.51.5-1.4-0.90.9
Number of licking bursts0.00.10.1-0.10.20.30.20.3-0.1-0.40.3
Context. condit. distance diff. score0.30.41.61.3-0.8-0.7-0.5-0.50.40.1-0.0
Locomotion velocity, session 10.00.00.00.00.10.10.10.1-0.1-0.10.1
Locomotion distance, session 11.82.33.0-0.51.41.51.61.6-1.6-1.71.7
Locomotion velocity, session 21.21.52.8-1.71.51.41.21.2-1.1-0.60.6
Locomotion distance, session 21.31.82.2-1.11.51.51.51.4-1.4-1.21.2
Locomotion velocity, session 31.21.32.40.20.90.91.11.2-1.3-1.51.6
Locomotion distance, session 30.10.10.20.10.30.30.40.4-0.5-0.40.5
Stereotopy head waving bouts, day 30.50.61.40.50.30.40.60.7-0.8-1.21.2
Stereotopy head waving duration, day 30.20.31.11.1-0.5-0.4-0.1-0.10.0-0.60.5
Locomotion velocity, session 70.80.91.50.00.80.81.01.0-1.1-1.21.2
Locomotion distance, session 70.50.70.8-0.70.90.90.90.9-0.9-0.70.7
Stereotopy head waving bouts, day 70.60.71.70.40.30.40.70.7-0.8-1.31.3
Stereotopy head waving duration, day 71.61.92.9-0.61.21.31.41.4-1.5-1.71.6
Locomotion velocity, session 81.01.22.0-1.41.31.31.11.1-0.9-0.60.6
Locomotion distance, session 80.10.10.40.6-0.00.00.10.2-0.2-0.40.5
Degree of sensitization distance0.70.70.8-0.70.90.90.90.9-0.9-0.80.8
Degree of sensitization stereotypy0.60.71.2-0.30.70.80.90.9-0.9-1.11.0
Conditioned locomotion0.60.72.9-1.70.60.40.1-0.00.30.9-1.0
Cocaine response after cond. corrected0.00.00.10.3-0.2-0.1-0.1-0.1-0.0-0.10.1
Cocaine response after cond. not corrected0.10.10.20.30.00.10.20.2-0.3-0.50.5
Cocaine response before conditioning0.10.10.2-0.20.30.30.30.4-0.3-0.50.3
Saline control response1.82.44.7-2.21.81.81.61.5-1.3-1.00.9
Bone: connectivity density5.28.39.8-1.92.93.03.13.1-2.6-3.13.0
Bone: cortical apparent density0.10.10.5-0.70.30.20.00.00.00.5-0.4
Bone: cortical area0.10.20.9-0.90.30.2-0.0-0.00.20.5-0.6
Bone: cortical porosity0.10.10.2-0.20.20.20.20.2-0.5-0.30.2
Bone: cortical porosity0.20.20.4-0.60.50.50.40.4-0.6-0.30.2
Bone: cortical thickness1.11.88.6-2.91.31.10.50.4-0.11.0-1.1
Bone: cortical thickness0.50.62.7-1.60.90.80.50.5-0.00.2-0.3
Bone: cortical tissue density0.10.20.8-0.90.40.30.20.1-0.10.5-0.4
Condit. Reinf. active minus inactive responses0.50.50.7-0.20.70.70.80.8-0.9-0.80.9
Condit. Reinf. active-inactive response ratio0.20.20.40.20.30.30.40.4-0.5-0.50.6
Condit. Reinf. active responses0.00.00.10.10.20.20.20.2-0.3-0.20.3
Condit. Reinf. inactive responses0.10.20.20.4-0.4-0.4-0.4-0.40.40.4-0.4
Incentive salience index mean0.40.50.6-0.30.70.70.70.7-0.8-0.70.7
Condit. Reinf. lever presses0.00.00.0-0.10.10.10.00.00.00.1-0.1
Condit. Reinf. active minus inactive responses0.30.51.10.70.10.20.50.5-0.7-1.01.1
Condit. Reinf. active-inactive response ratio0.30.52.11.5-0.8-0.7-0.4-0.40.1-0.30.4
Condit. Reinf. active responses0.91.32.50.10.80.91.11.2-1.3-1.61.6
Condit. Reinf. inactive responses1.42.12.4-1.01.51.51.61.5-1.5-1.51.4
Condit. Reinf. lever presses1.42.02.4-0.91.41.41.51.5-1.5-1.61.5
Condit. Reinf. lever reinforcers received1.31.83.0-0.11.11.21.41.4-1.5-1.71.7
Conditioned reinforcement - actives0.20.91.30.5-0.9-1.0-1.0-1.00.91.1-1.1
Conditioned reinforcement - inactives0.71.84.02.0-1.7-1.6-1.3-1.31.10.6-0.4
Conditioned locomotion6.29.212.83.6-3.5-3.5-3.2-3.12.72.1-2.0
Patch foraging indifference point 0 sec0.10.20.30.6-0.6-0.6-0.4-0.40.30.1-0.2
Patch foraging indifference point AUC0.10.20.8-0.90.50.40.20.1-0.40.4-0.4
Delay disc. indifference point, 0s delay1.11.32.70.00.70.81.01.0-1.5-1.61.5
Delay disc. indifference point, 16s delay0.30.51.41.2-0.9-0.8-0.6-0.60.20.1-0.1
Delay disc. indifference point, 2s delay0.10.20.40.6-0.2-0.00.10.2-0.4-0.60.6
Delay disc. indifference point, 24s delay0.10.10.2-0.3-0.2-0.2-0.3-0.30.30.4-0.5
Delay disc. indifference point, 4s delay0.60.71.4-0.10.60.70.80.8-1.2-0.91.0
Delay disc. indifference point, 8s delay0.30.40.6-0.40.50.60.60.7-0.8-0.80.8
Indifference point function ln k1.23.75.52.3-2.3-2.2-2.0-1.92.11.1-1.0
Indifference point function log k1.23.75.52.3-2.3-2.2-2.0-1.92.11.1-1.0
Patch foraging total patch changes 0 sec0.10.30.40.3-0.6-0.6-0.6-0.60.50.5-0.5
Patch foraging total patch changes 12 sec1.21.63.2-1.81.51.41.21.2-1.3-0.60.6
Patch foraging total patch changes 18 sec0.10.30.6-0.50.60.60.60.6-0.8-0.40.3
Patch foraging total patch changes 24 sec0.10.20.9-0.90.50.50.30.2-0.30.1-0.1
Patch foraging total patch changes 6 sec0.91.62.2-1.11.31.31.31.3-1.5-1.21.1
Patch foraging time to switch 0 sec1.35.16.0-1.32.22.32.42.4-2.3-2.42.4
Patch foraging water rate 0 sec2.910.812.52.4-3.4-3.5-3.5-3.53.43.2-3.2
Patch foraging water rate 12 sec3.313.315.53.1-3.9-3.9-3.9-3.93.73.4-3.3
Patch foraging water rate 18 sec1.02.22.61.4-1.6-1.6-1.5-1.51.61.3-1.2
Patch foraging water rate 24 sec4.05.76.81.5-2.5-2.5-2.6-2.62.42.5-2.4
Patch foraging water rate 6 sec3.34.96.11.3-2.2-2.2-2.3-2.32.52.3-2.3
Seeking ratio, delayed vs. immediate footshock0.50.81.3-0.00.60.70.90.9-1.1-1.11.2
Distance traveled before self-admin0.20.40.6-0.10.60.60.70.7-0.6-0.80.8
Distance traveled after self-admin0.00.10.1-0.10.30.20.20.20.2-0.30.3
Extensor digitorum longus weight3.413.532.8-5.74.64.23.63.4-3.2-1.01.0
Bone: elastic displacement1.72.24.2-0.1-1.1-1.3-1.5-1.61.32.0-2.0
Bone: elastic work0.50.62.9-1.70.80.60.30.2-0.20.7-0.7
Bone: endosteal estimation0.30.73.61.9-0.7-0.6-0.2-0.1-0.2-0.80.8
Bone: endosteal perimeter0.61.57.32.7-1.1-0.9-0.3-0.2-0.3-1.21.2
Epididymis fat weight1.99.716.94.1-3.7-3.6-3.2-3.12.91.6-1.7
Delta time in closed arm before/after self-admin0.50.51.4-1.20.80.70.50.5-0.80.1-0.0
Delta time in open arm before/after self-admin0.10.10.40.00.20.30.30.4-0.2-0.60.6
Diff in mean of infusions in LGA sessions0.10.31.0-1.00.60.60.40.4-0.2-0.10.0
Delay discount exponential model param0.50.61.00.1-0.6-0.7-0.8-0.81.01.0-1.0
Extinction: sum of active levers before priming1.72.53.1-1.61.71.81.71.7-1.3-1.41.4
Active lever presses in extinction session 60.60.61.6-1.21.00.90.70.7-0.8-0.00.1
Bone: final force1.11.82.4-1.51.61.51.41.4-1.1-1.00.9
Bone: final moment1.01.62.3-1.51.51.51.41.4-1.1-0.90.8
Food consumed during 24 hour testing period0.40.71.00.6-0.9-0.9-0.9-0.91.00.7-0.8
Glucose0.60.93.61.9-0.4-0.20.20.3-0.3-1.21.4
Heart weight0.60.92.30.60.40.50.80.9-0.9-1.51.4
Delay discount hyperbolic model param0.50.61.10.0-0.6-0.7-0.8-0.81.01.0-1.0
Intermittent access intake day 1-15 change0.73.65.22.3-2.2-2.1-2.0-1.92.01.2-1.2
Intermittent access intake escalation0.63.44.52.1-2.1-2.0-1.9-1.91.91.2-1.3
Intermittent access intake escalation 21.42.33.71.9-1.8-1.7-1.6-1.51.50.9-1.0
Intermitt. access day 1 inactive lever presses0.00.00.00.0-0.2-0.2-0.2-0.2-0.10.1-0.0
Intermitt. access day 15 inactive lever presses0.10.41.91.4-0.8-0.6-0.4-0.30.3-0.40.4
Intermitt. access escalation Index1.13.54.41.9-2.1-2.1-2.0-2.01.71.6-1.6
Intermittent access day 1 total infusions0.30.92.21.2-0.10.10.50.6-0.8-1.51.5
Intermittent access day 15 total infusions1.23.08.22.9-2.2-2.0-1.6-1.51.30.4-0.4
Intermittent access terminal intake (last 3 days)0.91.66.22.5-1.6-1.4-1.0-0.90.5-0.20.3
Intermittent access total infusions0.60.73.31.8-0.9-0.8-0.4-0.3-0.1-0.60.6
Intermittent access day 1 locomotion0.20.40.80.9-0.2-0.10.20.3-0.7-0.80.9
Intermittent access day 15 total locomotion0.62.57.62.7-2.0-1.8-1.4-1.31.10.2-0.2
Intermittent access total locomotion2.22.69.63.1-2.0-1.8-1.4-1.20.8-0.00.1
Intermittent access standard deviation0.10.51.51.2-0.9-0.8-0.7-0.60.70.2-0.1
Left kidney weight0.32.76.22.5-2.0-1.9-1.7-1.61.30.6-0.7
Right kidney weight0.53.24.32.0-2.1-2.0-1.9-1.91.81.2-1.3
Cocaine induced anxiety0.00.00.10.10.10.10.20.20.1-0.40.3
Post-drug Anxiety0.30.40.5-0.70.70.70.70.7-0.3-0.60.6
Baseline Anxiety0.10.20.6-0.80.50.50.40.4-0.2-0.00.1
Tail length0.10.73.4-1.80.70.60.20.10.20.7-0.8
Length with tail0.73.110.6-3.32.22.01.51.4-1.0-0.0-0.1
Length without tail0.52.67.3-2.72.11.91.51.4-1.2-0.30.2
Times rat made contact with spout1.01.11.3-0.71.11.11.11.1-1.0-1.21.1
Lifetime Intake0.30.41.71.3-0.6-0.5-0.2-0.1-0.2-0.50.5
Liver weight, left0.81.42.00.8-1.2-1.2-1.3-1.31.41.2-1.1
Liver weight, right1.32.32.91.4-1.7-1.7-1.6-1.61.71.2-1.2
Locomotor activity1.01.62.61.0-1.4-1.4-1.3-1.31.61.0-1.0
Locomotor testing distance0.82.02.91.2-1.5-1.5-1.5-1.51.71.0-1.1
Locomotor testing rearing0.10.41.51.2-0.7-0.6-0.4-0.40.5-0.00.1
Locomotion in novel chamber2.93.88.22.9-2.4-2.3-1.9-1.82.00.6-0.6
Locomotion in novel chamber post-restriction0.92.85.02.2-2.1-2.0-1.7-1.71.40.8-0.8
Fecal boli incidents, locomotor time 10.00.00.10.2-0.2-0.2-0.2-0.2-0.20.1-0.1
Change in fecal boli incidents, locomotor task0.20.20.2-0.30.40.40.40.5-0.4-0.40.4
Time >=10cm from walls, locomotor time 10.50.61.41.1-0.2-0.10.30.4-0.5-1.11.2
Bouts of movement, locomotor time 10.10.20.7-0.80.30.2-0.1-0.1-0.20.5-0.6
Total resting periods, locomotor time 10.10.20.5-0.4-0.0-0.1-0.3-0.30.20.6-0.7
Rest time, locomotor task time 11.83.03.61.5-1.9-1.9-1.8-1.81.81.5-1.4
Distance moved, locomotor task time 10.41.21.8-0.21.01.11.21.2-1.1-1.31.3
Vertical activity count, locomotor time 10.00.20.90.9-0.4-0.3-0.1-0.10.2-0.50.4
Time >=10cm from walls, locomotor time 20.10.20.30.4-0.5-0.5-0.5-0.50.30.5-0.5
Bouts of movement, locomotor time 20.10.30.8-0.90.60.50.40.4-0.9-0.10.2
Total resting periods, locomotor time 20.00.20.7-0.60.40.40.30.3-0.8-0.20.2
Rest time, locomotor task time 20.40.72.61.6-1.0-0.9-0.7-0.60.4-0.20.1
Distance moved, locomotor task time 20.20.20.9-1.00.40.30.10.10.20.5-0.4
Vertical activity count, locomotor time 20.51.32.4-0.3-0.7-0.8-1.1-1.11.31.5-1.5
Light reinforcement 10.31.31.51.2-1.2-1.2-1.2-1.21.11.0-0.9
Light reinforcement 21.32.93.92.0-1.9-1.9-1.8-1.81.61.3-1.3
Bone: marrow area0.30.83.71.9-0.8-0.6-0.2-0.1-0.2-0.90.8
Bone: maximum diameter0.10.30.40.5-0.6-0.6-0.6-0.60.60.4-0.5
Bone: maximum force2.75.26.1-1.52.42.42.52.5-2.5-2.32.3
Bone: maximum moment2.54.75.6-1.42.32.32.32.3-2.4-2.12.1
Mean time between licks in bursts0.10.40.9-0.90.70.70.60.6-0.5-0.20.2
Mean num. licks in bursts0.00.10.2-0.10.30.30.40.3-0.5-0.40.4
Cd content in liver0.91.02.31.5-1.2-1.2-1.0-0.90.80.4-0.3
Co content in liver1.92.23.30.5-1.3-1.4-1.6-1.61.61.8-1.8
Cu content in liver0.00.00.00.1-0.2-0.2-0.2-0.20.10.2-0.1
Fe content in liver0.10.10.2-0.40.30.30.20.2-0.2-0.00.0
K content in liver0.80.80.9-0.60.90.90.90.9-0.9-0.90.8
Mg content in liver0.10.10.50.7-0.2-0.2-0.00.0-0.1-0.40.4
Mn content in liver1.41.63.0-1.71.51.41.31.2-1.1-0.70.7
Na content in liver0.50.61.00.0-0.6-0.6-0.8-0.80.91.0-1.0
Rb content in liver0.30.31.31.2-0.3-0.20.00.1-0.2-0.70.7
Se content in liver0.10.20.40.40.00.10.20.3-0.4-0.60.7
Sr content in liver0.50.42.1-1.40.70.60.30.3-0.10.5-0.5
Zn content in liver0.10.10.5-0.70.20.20.00.00.10.4-0.4
Bone: minimum diameter0.40.92.01.3-0.10.10.40.5-0.9-1.41.4
Time in familiar zone, hab. session 10.10.10.50.7-0.2-0.2-0.1-0.0-0.1-0.30.4
Time in novel zone, hab. session 10.00.00.1-0.2-0.1-0.1-0.1-0.10.30.2-0.3
Total zone transitions, hab. session 10.40.60.8-0.80.90.90.80.8-0.6-0.60.5
Total locomotion distance, hab. session 10.10.20.60.8-0.5-0.5-0.4-0.30.3-0.0-0.0
Locomotion velocity, hab. session 10.00.00.10.4-0.2-0.2-0.2-0.10.20.0-0.0
Time in familiar zone, hab. session 20.10.10.5-0.70.30.20.0-0.00.10.5-0.5
Time in novel zone, hab. session 20.50.51.20.20.40.40.60.7-0.8-1.11.1
Total zone transitions, hab. session 24.65.87.4-1.02.32.42.62.6-2.6-2.72.7
Total locomotion distance, hab. session 20.91.22.10.10.80.91.11.1-1.2-1.41.4
Locomotion velocity, hab. session 20.60.81.60.40.50.60.80.8-0.9-1.31.2
Novel to familiar place preference ratio0.30.40.7-0.20.60.60.70.7-0.6-0.80.8
Novelty place preference0.20.30.60.20.30.40.50.5-0.5-0.80.7
Time in novel zone, NPP test0.20.30.70.10.40.40.50.5-0.5-0.80.7
Total zone transitions, NPP test1.82.63.1-1.11.71.71.71.8-1.7-1.61.6
Total locomotion distance, NPP test0.20.30.50.20.40.40.50.6-0.6-0.70.7
Locomotion velocity, NPP test0.10.10.30.30.20.30.40.4-0.5-0.50.5
Intraocular pressure1.11.92.50.7-1.3-1.4-1.5-1.51.21.5-1.6
Delta distance traveled before/after self-admin0.10.10.4-0.2-0.1-0.2-0.3-0.30.70.4-0.4
Delta ambulatory time before/after self-admin0.10.10.3-0.3-0.0-0.1-0.2-0.20.60.4-0.4
Parametrial fat weight1.12.58.22.9-2.0-1.8-1.5-1.31.00.2-0.2
Pavlov. Cond. lever latency0.30.40.60.6-0.7-0.7-0.7-0.70.60.5-0.5
Pavlov. Cond. magazine entry latency0.40.51.20.30.40.50.70.7-0.7-1.11.1
Pavlov. Cond. change in total contacts0.10.10.50.7-0.2-0.10.00.1-0.1-0.50.4
Pavlov. Cond. index score0.00.00.10.3-0.1-0.0-0.00.00.1-0.10.1
Pavlov. Cond. latency score0.10.10.10.20.20.20.20.3-0.2-0.40.4
Pavlov. Cond. lever contacts0.10.10.2-0.10.40.40.40.4-0.4-0.40.4
Pavlov. Cond. magazine entry number0.00.10.1-0.40.30.20.20.2-0.3-0.10.1
Pavlov. Cond. intertrial magazine entries0.70.81.20.3-0.8-0.9-0.9-1.00.91.1-1.0
Pavlov. Cond. lever-magazine prob. diff.0.00.00.00.20.00.00.10.1-0.0-0.20.2
Pavlov. Cond. response bias0.10.10.10.3-0.3-0.2-0.3-0.20.40.1-0.2
Pavlov. Cond. lever latency0.00.00.00.10.00.00.00.1-0.20.00.1
Pavlov. Cond. magazine entry latency3.85.46.4-2.02.52.52.52.5-2.3-2.22.1
Pavlov. Cond. change in total contacts0.40.91.5-0.40.80.91.01.0-0.9-1.21.1
Pavlov. Cond. index score1.01.51.8-1.01.31.31.31.3-1.2-1.31.2
Pavlov. Cond. latency score0.71.11.2-0.81.11.11.11.1-1.0-1.11.0
Pavlov. Cond. lever contacts0.00.00.0-0.20.10.10.10.10.1-0.20.0
Pavlov. Cond. magazine entry number4.96.47.72.3-2.8-2.8-2.7-2.72.52.3-2.2
Pavlov. Cond. intertrial magazine entries0.91.92.41.5-1.6-1.5-1.5-1.41.31.1-1.0
Pavlov. Cond. lever-magazine prob. diff.1.32.02.3-1.21.51.51.51.5-1.4-1.41.3
Pavlov. Cond. response bias1.11.61.8-1.01.31.31.31.3-1.2-1.31.2
Time in closed arm before self-admin0.10.21.01.0-0.4-0.3-0.1-0.1-0.1-0.50.5
Time in closed arm after self-admin0.00.10.10.2-0.2-0.2-0.3-0.2-0.20.3-0.2
Time in open arm before self-admin0.20.20.8-0.90.30.20.1-0.00.40.5-0.5
Time in open arm after self-admin0.40.50.7-0.80.80.80.80.7-0.3-0.60.5
Bone: periosteal estimation0.00.10.40.6-0.3-0.3-0.2-0.20.0-0.20.1
Bone: periosteal perimeter0.10.30.70.50.10.20.40.4-0.6-0.80.8
Bone: post-yield work4.06.913.60.71.72.02.52.6-2.9-3.63.7
Progressive ratio test 1 active lever presses0.00.00.10.1-0.2-0.2-0.2-0.2-0.20.3-0.2
Progressive ratio test 1 breakpoint0.00.00.10.0-0.1-0.2-0.1-0.1-0.30.3-0.2
Progressive ratio test 1 inactive lever presses0.00.00.10.1-0.0-0.1-0.0-0.0-0.40.10.0
Progressive ratio test 2 active lever presses0.50.62.01.4-1.0-1.0-0.7-0.70.40.2-0.1
Progressive ratio test 2 breakpoint0.50.71.91.4-1.0-1.0-0.8-0.70.40.2-0.2
Progressive ratio test 2 inactive lever presses1.23.79.73.1-2.4-2.3-1.8-1.71.30.6-0.6
Incentive Sensitization - Responses0.20.61.0-0.10.60.70.80.8-0.8-1.01.0
Incentive Sensitization - Breakpoint0.20.40.80.20.40.50.60.7-0.6-0.90.9
Sum of active levers in priming session hrs 5-62.52.44.4-0.0-1.0-1.2-1.5-1.61.82.1-2.0
Progressive ratio1.85.48.1-1.02.12.22.42.4-2.3-2.92.7
Food seeking constrained by brief footshock0.20.20.3-0.50.50.50.50.5-0.4-0.50.5
Seeking ratio, punishment vs. effort1.63.54.81.0-1.8-1.8-2.0-2.01.72.2-2.1
Retroperitoneal fat weight4.721.241.06.4-5.6-5.3-4.7-4.54.32.1-2.2
Reaction time number correct0.00.20.5-0.70.30.2-0.0-0.10.10.6-0.6
Reaction time mean minus median0.53.44.2-2.02.02.01.91.9-2.1-1.41.3
Reaction time mean minus median AUC0.31.83.5-1.91.61.51.41.3-1.4-0.70.7
Reaction time num false alarms0.40.71.3-0.3-0.5-0.6-0.8-0.80.91.1-1.1
Reaction time num false alarms AUC0.10.31.1-1.10.20.1-0.1-0.10.40.6-0.7
Reaction time trials correct on left0.00.20.5-0.70.30.2-0.0-0.10.10.6-0.6
Reaction time trials on left0.10.20.7-0.80.30.2-0.0-0.00.10.7-0.6
Reaction time mean0.10.30.6-0.10.50.50.60.6-0.5-0.80.7
Reaction time mean AUC0.10.30.60.00.40.50.60.6-0.5-0.80.7
Median of all reaction times0.10.20.50.50.10.20.30.4-0.2-0.70.7
Reaction time omissions1.42.34.2-2.01.81.71.51.5-1.5-0.70.7
Reaction time false alarm rate0.10.20.3-0.4-0.2-0.2-0.3-0.40.50.4-0.6
Reaction time premature initiation rate1.62.55.3-2.31.91.81.61.6-1.3-0.80.8
Reaction time premature initiations0.92.67.6-2.82.01.91.51.4-1.1-0.30.4
Std. dev. reaction times0.41.31.5-1.21.21.21.21.2-1.2-0.90.9
Reaction time trials completed0.10.20.7-0.80.30.2-0.0-0.00.10.7-0.6
Reaction time trials AUC0.00.10.5-0.70.30.20.0-0.00.10.6-0.5
Run reversals in cocaine runway, females1.61.82.2-0.91.41.41.51.5-1.4-1.31.4
Run reversals in cocaine runway, males0.40.40.8-0.3-0.4-0.4-0.6-0.60.80.9-0.9
Latency to leave start box in cocaine runway0.40.51.20.50.30.40.60.7-0.6-1.11.1
Latency to leave start box in cocaine runway, F0.40.61.10.20.50.60.70.8-0.7-1.11.1
Latency to leave start box in cocaine runway, M0.00.00.10.10.20.10.20.2-0.0-0.20.2
Std. dev. time between licks in bursts0.20.41.0-1.00.1-0.0-0.3-0.30.51.0-1.0
Total sessions with >9 infusions0.30.40.6-0.40.60.60.60.6-0.8-0.60.6
Short access day 1 total inactive lever presses0.51.12.11.5-1.3-1.3-1.1-1.00.80.5-0.4
Short access day 10 total inactive lever presses0.00.00.0-0.00.10.10.10.1-0.2-0.20.2
Short access day 1 total infusions0.20.31.11.0-0.7-0.7-0.5-0.40.2-0.00.1
Short access day 10 total infusions0.81.42.50.10.80.91.11.2-1.5-1.51.6
Short access total infusions0.30.50.90.00.40.50.70.7-0.9-0.90.9
Short access day 1 locomotion0.20.31.01.0-0.6-0.6-0.4-0.40.10.00.1
Short access day 10 total locomotion0.00.20.70.8-0.2-0.20.10.1-0.3-0.40.6
Short access total locomotion0.10.20.91.0-0.5-0.4-0.2-0.2-0.1-0.20.4
One hour access (0.3 mA shock)2.02.35.72.4-1.9-1.8-1.5-1.41.10.5-0.4
Compulsive drug intake0.60.94.1-2.01.00.90.60.5-0.40.3-0.3
One hour access (shock baseline)1.54.010.03.2-2.5-2.4-2.0-1.91.50.7-0.7
Social response proportion0.91.11.3-0.91.11.11.11.1-1.1-1.11.0
Social responses0.20.30.8-0.90.70.60.40.4-0.60.0-0.0
Social time0.40.60.9-0.90.90.90.80.8-0.9-0.40.5
Soleus weight4.212.515.83.7-4.0-3.9-3.7-3.73.42.8-2.7
Bone: stiffness2.13.94.8-1.01.92.02.12.1-2.1-2.22.1
Tibialis anterior weight2.58.531.9-5.63.63.12.22.0-1.90.8-0.8
Time to tail flick, vehicle, before self-admin1.21.42.4-0.41.01.11.31.3-1.0-1.61.5
Time to tail flick, vehicle, after self-admin1.83.75.2-1.41.92.02.02.0-2.3-1.91.8
Time to tail flick, test, before self-admin0.70.81.70.80.20.40.60.7-1.1-1.31.3
Time to tail flick, test, after self-admin0.00.00.10.1-0.1-0.1-0.1-0.10.10.2-0.2
Delta time to tail flick, vehicle, before/after SA1.11.22.5-0.91.21.11.11.1-1.6-0.70.7
Delta time to tail flick, test, before/after SA1.31.63.6-0.8-0.5-0.7-1.1-1.11.41.9-1.9
Tibia length0.30.82.1-0.6-0.4-0.5-0.8-0.80.91.3-1.5
Ambulatory time before self-admin0.20.61.0-0.00.60.60.80.8-0.7-1.01.0
Ambulatory time after self-admin0.10.20.70.8-0.2-0.10.10.10.1-0.70.6
Bone: tissue strength0.10.10.20.40.00.10.10.2-0.3-0.40.4
Total heroin consumption2.52.95.9-2.42.01.91.71.7-1.6-0.80.8
Bone: trabecular number2.44.46.8-0.81.92.12.32.3-1.9-2.62.5
Bone: trabecular spacing0.71.11.80.6-1.0-1.1-1.1-1.20.61.3-1.2
Bone: trabecular thickness0.50.72.10.50.30.50.70.8-0.4-1.41.4
Bone: trabecular tissue density5.69.812.33.1-3.5-3.5-3.4-3.33.02.6-2.6
Water consumed over 24 hours0.61.31.5-1.11.21.21.21.2-1.0-1.11.0
Number of responses in last shaping day0.00.00.1-0.30.20.20.10.1-0.30.2-0.1