Hub : Genes

Mrpl49

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose mRNA stability Mrpl49 0.08 0.04 3.3e-08 0.04 0.05 0.04 0.05 1.9e-05 3.0e-06 1.2e-05 3.4e-06
2 Liver mRNA stability Mrpl49 0.17 0.07 0.0e+00 0.12 0.12 0.11 0.12 3.0e-13 6.3e-13 1.5e-12 1.0e-12
3 pVTA mRNA stability Mrpl49 0.2 0.11 1.2e-06 0.12 0.09 0.07 0.11 8.0e-06 9.7e-05 8.2e-04 2.6e-05
4 NAcc mRNA stability Mrpl49 0.08 0.05 1.3e-07 0.04 0.06 0.06 0.06 1.0e-05 6.3e-08 1.1e-07 1.8e-07
5 PL mRNA stability Mrpl49 0.1 0.05 3.2e-14 0.11 0.12 0.11 0.12 4.9e-12 1.7e-13 2.6e-12 9.4e-13
6 BLA mRNA stability Mrpl49 0.13 0.08 1.3e-05 0.1 0.08 0.06 0.08 8.3e-06 6.3e-05 6.3e-04 6.3e-05
7 Brain mRNA stability Mrpl49 0.07 0.04 5.8e-08 0.07 0.07 0.06 0.05 5.5e-07 6.5e-07 1.1e-06 1.3e-05
8 Adipose gene expression Mrpl49 0.08 0.04 1.9e-05 0.01 0.02 0.02 0.01 2.1e-02 4.2e-03 4.4e-03 2.9e-02
9 OFC gene expression Mrpl49 0.3 0.14 1.9e-03 0.04 0.03 0.04 0.1 4.7e-02 7.7e-02 4.2e-02 2.8e-03
10 Brain gene expression Mrpl49 0.22 0.09 7.5e-11 0.11 0.12 0.1 0.13 2.1e-10 1.3e-11 5.9e-10 2.8e-12
11 PL gene expression Mrpl49 0.22 0.08 1.3e-15 0.12 0.16 0.15 0.15 4.3e-13 9.3e-17 3.0e-16 1.4e-16
12 NAcc gene expression Mrpl49 0.11 0.06 1.4e-06 0.06 0.06 0.06 0.06 2.2e-07 8.8e-08 3.0e-07 3.7e-07
13 BLA gene expression Mrpl49 0.24 0.13 2.6e-04 0.02 0.04 0.05 0.03 2.3e-02 2.0e-03 1.4e-03 9.4e-03
14 pVTA gene expression Mrpl49 0.14 0.08 1.9e-03 0.01 0.03 0.04 0.04 9.6e-02 1.7e-02 5.6e-03 1.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.30.51.70.7-0.7-0.61.10.3-0.5-0.5-0.2-0.7-0.30.10.1-1.3-1.2
Area under the delay curve0.40.41.5-0.20.30.10.5-0.0-0.1-0.30.30.90.90.90.9-0.7-1.2
BMI with tail2.27.116.52.9-3.0-2.94.02.3-2.6-2.51.1-0.20.81.61.6-4.1-4.1
BMI without tail1.63.37.71.6-1.4-1.72.51.6-1.8-2.01.30.71.21.71.6-2.4-2.8
Body weight2.39.518.14.2-4.2-4.24.33.8-3.8-3.82.40.20.91.21.0-1.9-2.2
Weight adjusted by age1.21.33.21.8-1.6-1.71.31.4-1.4-1.20.6-0.9-0.6-0.5-0.60.50.6
Bone surface2.13.79.13.0-2.8-2.82.61.9-1.9-1.80.1-2.1-1.4-1.1-1.2-0.5-0.2
Bone volume1.01.64.71.7-1.5-1.51.50.7-0.7-0.7-0.7-2.2-1.7-1.3-1.4-0.4-0.1
Breakpoint value in progressive ratio session1.82.04.52.1-2.1-1.91.81.6-1.7-1.50.6-1.2-0.8-0.6-0.70.80.3
Number of licking bursts0.20.20.50.6-0.7-0.50.60.4-0.3-0.3-0.0-0.5-0.4-0.4-0.40.30.2
Context. condit. distance diff. score1.01.22.9-1.71.61.7-1.3-1.31.31.1-0.60.50.30.50.7-0.8-0.5
Locomotion velocity, session 10.40.51.40.1-0.0-0.10.10.5-0.6-0.50.91.21.11.00.9-0.5-0.5
Locomotion distance, session 11.01.23.30.7-0.7-0.81.30.9-1.1-0.90.90.81.11.21.2-1.5-1.8
Locomotion velocity, session 21.92.24.71.9-1.8-1.92.21.8-1.9-1.91.30.30.60.80.7-0.9-1.3
Locomotion distance, session 21.11.53.20.9-0.8-1.01.51.1-1.3-1.11.11.01.31.31.3-1.3-1.8
Locomotion velocity, session 30.60.74.1-0.50.40.4-0.1-0.30.10.4-0.10.40.60.81.0-2.0-1.4
Locomotion distance, session 30.10.10.2-0.20.20.2-0.2-0.10.10.00.00.30.30.30.3-0.4-0.3
Stereotopy head waving bouts, day 30.91.05.4-0.80.80.8-0.4-0.50.30.7-0.10.50.81.11.3-2.3-1.5
Stereotopy head waving duration, day 30.50.51.5-0.90.90.9-0.7-0.80.71.0-0.5-0.10.10.30.4-1.2-0.6
Locomotion velocity, session 70.70.73.2-0.80.80.8-0.1-0.90.60.9-0.8-0.2-0.00.40.6-1.8-1.5
Locomotion distance, session 70.70.82.7-0.50.20.30.2-0.1-0.20.00.40.91.11.31.5-1.6-1.6
Stereotopy head waving bouts, day 70.50.61.6-0.20.40.3-0.2-0.80.80.7-1.2-1.2-1.2-1.0-1.00.10.3
Stereotopy head waving duration, day 70.60.71.71.2-1.1-1.11.30.6-0.6-0.7-0.2-1.2-1.0-0.7-0.80.2-0.1
Locomotion velocity, session 81.21.52.61.0-1.1-1.10.81.5-1.5-1.51.61.31.41.21.1-0.6-0.6
Locomotion distance, session 80.30.42.8-0.50.50.5-0.2-0.50.30.3-0.30.20.40.50.7-1.7-1.1
Degree of sensitization distance0.50.52.6-0.20.00.10.2-0.1-0.10.10.10.50.60.80.9-1.6-1.3
Degree of sensitization stereotypy0.70.82.40.8-0.7-0.70.70.1-0.0-0.2-0.7-1.5-1.4-1.2-1.30.70.5
Conditioned locomotion1.01.22.41.5-1.5-1.51.21.5-1.5-1.41.20.40.50.50.4-0.3-0.3
Cocaine response after cond. corrected1.21.32.2-1.51.51.4-1.2-0.80.70.80.11.31.31.21.3-1.3-0.8
Cocaine response after cond. not corrected0.91.01.8-1.31.31.2-1.0-0.70.60.70.11.11.11.11.2-1.3-0.8
Cocaine response before conditioning0.50.61.21.0-1.0-0.90.80.6-0.5-0.6-0.1-1.1-1.0-0.8-0.80.70.5
Saline control response2.93.76.82.5-2.6-2.52.32.6-2.5-2.62.10.60.91.00.9-0.3-0.9
Bone: connectivity density1.21.84.61.9-1.9-1.82.11.4-1.6-1.60.5-0.8-0.30.20.1-1.0-1.1
Bone: cortical apparent density0.30.41.20.5-0.6-0.60.80.6-0.7-0.60.70.50.40.20.21.1-0.1
Bone: cortical area0.40.61.31.1-1.0-1.00.60.7-0.6-0.6-0.0-1.0-0.8-0.8-0.80.10.5
Bone: cortical porosity0.10.10.40.3-0.3-0.30.60.2-0.3-0.10.0-0.2-0.00.10.1-0.4-0.6
Bone: cortical porosity0.40.41.10.9-0.9-0.81.10.8-0.9-0.70.50.00.20.30.3-0.4-0.6
Bone: cortical thickness1.72.85.42.1-2.1-2.21.82.3-2.3-2.32.10.70.80.70.41.00.1
Bone: cortical thickness1.11.33.00.6-0.7-0.80.71.3-1.2-1.31.71.51.51.31.20.3-0.3
Bone: cortical tissue density0.40.51.40.6-0.7-0.70.90.8-0.8-0.70.80.60.40.30.21.2-0.1
Condit. Reinf. active minus inactive responses0.20.20.50.3-0.4-0.40.70.4-0.5-0.40.40.30.40.40.4-0.2-0.6
Condit. Reinf. active-inactive response ratio0.10.10.40.1-0.2-0.20.40.2-0.2-0.10.20.10.10.10.10.6-0.1
Condit. Reinf. active responses0.10.10.30.1-0.2-0.10.3-0.0-0.00.0-0.2-0.2-0.10.00.1-0.6-0.6
Condit. Reinf. inactive responses0.20.31.6-0.20.20.3-0.2-0.50.50.5-0.8-0.6-0.4-0.3-0.2-1.3-0.5
Incentive salience index mean0.40.41.30.5-0.6-0.61.00.5-0.6-0.60.40.30.40.60.6-0.9-1.1
Condit. Reinf. lever presses0.20.20.90.7-0.7-0.60.60.4-0.4-0.4-0.1-0.2-0.1-0.1-0.1-1.0-0.6
Condit. Reinf. active minus inactive responses0.60.82.0-0.30.40.3-0.5-0.80.90.8-1.2-1.4-1.3-1.1-1.10.20.7
Condit. Reinf. active-inactive response ratio2.02.04.3-0.70.90.8-1.1-1.51.51.6-2.1-2.0-2.0-1.7-1.6-0.30.9
Condit. Reinf. active responses0.10.20.70.2-0.2-0.20.3-0.20.20.2-0.5-0.8-0.7-0.6-0.60.30.0
Condit. Reinf. inactive responses0.60.81.40.5-0.6-0.71.20.8-0.9-0.91.10.91.01.01.00.1-1.1
Condit. Reinf. lever presses1.21.73.71.9-1.8-1.81.41.1-0.9-0.9-0.1-1.6-1.3-1.3-1.40.60.6
Condit. Reinf. lever reinforcers received0.30.41.00.6-0.6-0.60.60.1-0.1-0.1-0.4-1.0-0.9-0.8-0.80.70.3
Conditioned reinforcement - actives1.31.32.9-0.30.60.6-1.0-0.80.80.9-1.3-1.1-1.4-1.7-1.70.81.5
Conditioned reinforcement - inactives6.16.910.1-2.72.72.9-3.1-3.23.22.9-3.0-2.0-2.4-2.3-2.11.32.3
Conditioned locomotion6.27.514.7-3.43.43.4-3.8-3.43.53.4-2.7-0.6-1.3-1.8-1.51.02.0
Patch foraging indifference point 0 sec0.00.00.1-0.30.10.3-0.1-0.30.20.2-0.2-0.2-0.2-0.1-0.0-0.0-0.0
Patch foraging indifference point AUC2.02.35.22.3-2.1-2.31.81.7-1.5-1.70.7-1.0-0.8-0.8-1.01.20.6
Delay disc. indifference point, 0s delay1.11.23.5-0.61.00.50.2-0.20.1-0.30.41.91.71.41.4-1.4-1.7
Delay disc. indifference point, 16s delay0.70.71.5-1.10.91.0-0.5-1.21.11.2-1.1-0.7-0.7-0.4-0.30.1-0.2
Delay disc. indifference point, 2s delay0.10.10.4-0.30.40.3-0.1-0.30.20.0-0.20.10.20.20.2-0.6-0.3
Delay disc. indifference point, 24s delay0.50.51.8-0.30.30.30.00.2-0.4-0.40.81.31.21.11.0-0.1-0.7
Delay disc. indifference point, 4s delay0.91.02.4-0.50.50.30.30.1-0.2-0.50.71.51.51.61.6-1.1-1.4
Delay disc. indifference point, 8s delay0.70.82.1-0.20.3-0.00.40.3-0.4-0.50.81.41.41.31.3-0.8-1.2
Indifference point function ln k4.76.615.3-3.93.73.8-3.2-2.82.62.8-0.91.91.41.51.9-1.8-0.9
Indifference point function log k4.76.615.3-3.93.73.8-3.2-2.82.62.8-0.91.91.41.51.9-1.8-0.9
Patch foraging total patch changes 0 sec0.00.00.1-0.20.00.2-0.2-0.0-0.1-0.00.20.30.20.20.30.1-0.0
Patch foraging total patch changes 12 sec2.53.37.62.6-2.7-2.62.62.3-2.2-2.31.3-0.5-0.1-0.0-0.20.6-0.4
Patch foraging total patch changes 18 sec0.30.40.90.9-0.9-0.90.90.5-0.5-0.6-0.1-0.8-0.6-0.5-0.60.1-0.1
Patch foraging total patch changes 24 sec1.41.73.71.9-1.9-1.91.41.8-1.7-1.71.2-0.1-0.0-0.1-0.30.80.4
Patch foraging total patch changes 6 sec0.71.01.81.1-1.4-1.21.21.2-1.3-1.21.00.30.50.70.6-0.4-0.8
Patch foraging time to switch 0 sec1.01.54.41.8-1.8-1.62.11.0-1.1-1.2-0.1-1.1-0.6-0.3-0.3-1.0-1.2
Patch foraging water rate 0 sec2.33.710.4-2.72.72.6-3.2-2.22.32.3-1.10.5-0.1-0.4-0.30.91.7
Patch foraging water rate 12 sec4.26.516.2-3.93.93.7-4.0-2.62.62.7-0.62.21.40.91.10.11.0
Patch foraging water rate 18 sec1.82.55.4-2.32.22.2-2.2-1.41.31.5-0.11.71.31.21.3-0.9-0.2
Patch foraging water rate 24 sec2.12.98.0-2.62.72.4-2.8-1.81.92.0-0.61.10.60.40.6-0.20.8
Patch foraging water rate 6 sec2.33.37.9-2.72.62.5-2.8-1.61.61.8-0.02.11.51.21.4-0.50.3
Seeking ratio, delayed vs. immediate footshock0.10.10.6-0.3-0.00.30.4-0.20.20.3-0.10.20.20.40.5-0.0-0.8
Distance traveled before self-admin0.50.61.11.0-0.9-0.90.70.4-0.5-0.4-0.3-1.0-0.9-1.0-1.10.50.5
Distance traveled after self-admin0.40.51.70.5-0.7-0.50.30.2-0.1-0.1-0.3-1.3-1.1-0.8-0.90.90.7
Extensor digitorum longus weight4.517.635.46.0-5.8-5.95.85.4-5.5-5.43.60.10.91.20.8-0.7-1.9
Bone: elastic displacement0.91.02.8-1.31.21.1-1.4-0.40.50.50.61.71.31.01.10.10.3
Bone: elastic work1.31.73.70.8-0.8-0.90.71.5-1.5-1.51.91.71.71.61.5-0.2-0.6
Bone: endosteal estimation0.81.86.1-1.11.31.3-1.0-1.61.51.5-1.8-1.0-0.8-0.5-0.3-2.5-0.8
Bone: endosteal perimeter1.53.17.1-1.21.51.5-1.4-2.12.12.1-2.7-2.1-1.9-1.5-1.3-1.80.1
Epididymis fat weight1.84.27.8-2.62.72.5-2.5-2.82.82.6-2.4-0.6-0.9-0.8-0.6-1.10.3
Delta time in closed arm before/after self-admin2.01.94.7-0.1-0.1-0.00.20.8-0.8-0.91.61.92.12.22.2-1.4-1.5
Delta time in open arm before/after self-admin1.41.33.30.4-0.2-0.2-0.0-0.30.40.4-1.0-1.6-1.7-1.8-1.81.61.5
Diff in mean of infusions in LGA sessions0.30.40.80.7-0.8-0.60.40.6-0.5-0.60.4-0.8-0.6-0.3-0.40.90.7
Delay discount exponential model param0.30.41.20.2-0.3-0.1-0.5-0.10.20.4-0.4-0.8-0.9-0.9-0.80.61.1
Extinction: sum of active levers before priming2.72.76.72.3-2.4-2.22.61.9-2.0-2.01.0-1.0-0.40.0-0.10.2-0.7
Active lever presses in extinction session 61.81.73.71.9-1.6-1.70.91.3-1.3-1.20.3-1.2-1.1-1.2-1.41.11.4
Bone: final force1.52.56.12.5-2.4-2.42.12.0-2.0-1.90.9-0.7-0.3-0.1-0.3-0.5-0.4
Bone: final moment1.42.25.42.3-2.2-2.22.01.8-1.9-1.80.9-0.6-0.3-0.1-0.3-0.5-0.4
Food consumed during 24 hour testing period0.60.72.20.3-0.2-0.2-0.3-0.00.20.2-0.4-0.9-1.0-1.2-1.21.51.5
Glucose1.32.03.7-1.81.81.8-1.4-1.91.81.9-1.6-0.4-0.4-0.10.1-1.6-0.8
Heart weight2.02.96.4-2.52.52.5-2.0-2.11.92.0-1.11.00.70.60.8-1.2-0.6
Delay discount hyperbolic model param0.40.41.10.1-0.2-0.0-0.5-0.10.20.4-0.4-0.9-0.9-0.9-0.90.61.1
Intermittent access intake day 1-15 change1.81.73.6-0.70.81.0-1.5-1.11.21.1-1.3-1.3-1.6-1.7-1.61.31.9
Intermittent access intake escalation1.41.32.2-0.70.70.9-1.2-1.11.11.0-1.2-1.2-1.4-1.4-1.31.01.5
Intermittent access intake escalation 21.31.33.2-0.30.30.5-0.9-0.60.80.7-1.0-1.3-1.5-1.6-1.61.51.8
Intermitt. access day 1 inactive lever presses1.82.03.5-1.71.71.6-1.6-1.91.81.8-1.6-0.9-1.0-0.8-0.70.30.7
Intermitt. access day 15 inactive lever presses3.33.75.4-1.81.81.8-2.1-2.32.22.2-2.3-1.9-2.1-1.8-1.70.71.6
Intermitt. access escalation Index2.32.04.1-2.02.01.7-1.1-1.51.31.3-0.51.41.21.11.3-1.4-1.4
Intermittent access day 1 total infusions3.94.69.0-2.72.82.7-2.2-3.02.72.8-2.7-0.5-0.7-0.6-0.3-2.0-0.7
Intermittent access day 15 total infusions7.17.913.9-3.23.43.4-3.4-3.73.63.5-3.5-1.6-1.9-2.0-1.6-0.41.3
Intermittent access terminal intake (last 3 days)5.76.211.2-2.52.82.8-2.9-3.23.13.0-3.4-1.7-2.0-2.1-1.8-0.71.1
Intermittent access total infusions4.34.79.0-2.42.62.5-2.3-3.02.82.8-3.0-1.2-1.4-1.5-1.2-1.20.3
Intermittent access day 1 locomotion2.83.06.1-2.32.32.1-1.5-2.21.92.0-1.60.40.40.50.8-2.5-1.5
Intermittent access day 15 total locomotion4.54.88.6-2.52.52.6-2.5-2.92.82.7-2.8-1.4-1.7-1.6-1.4-0.21.0
Intermittent access total locomotion5.36.011.8-2.82.92.8-2.5-3.43.23.1-3.4-1.5-1.7-1.5-1.2-1.50.1
Intermittent access standard deviation1.51.52.6-1.11.31.2-1.6-1.41.41.4-1.4-0.6-1.0-1.3-1.20.71.4
Left kidney weight0.61.73.0-1.31.41.4-1.4-1.61.71.4-1.6-1.1-1.2-1.1-1.00.10.8
Right kidney weight0.71.93.8-0.40.50.6-1.1-1.11.31.1-1.6-1.8-1.9-2.0-2.00.91.7
Cocaine induced anxiety0.20.30.70.20.0-0.0-0.2-0.20.10.1-0.5-0.7-0.8-0.8-0.80.20.7
Post-drug Anxiety1.01.12.21.5-1.2-1.20.60.9-0.9-0.70.1-1.3-1.1-1.2-1.20.61.3
Baseline Anxiety1.41.53.21.7-1.8-1.61.41.8-1.7-1.51.4-0.20.20.50.40.3-0.0
Tail length0.72.14.31.5-1.2-1.50.92.0-1.8-2.02.11.51.20.80.51.20.6
Length with tail1.24.69.13.0-2.9-3.02.23.0-2.9-2.82.30.60.70.30.00.90.5
Length without tail1.12.57.02.4-2.6-2.41.72.1-2.0-1.71.3-0.20.1-0.1-0.20.10.1
Times rat made contact with spout0.60.71.20.6-0.7-0.71.10.9-1.0-1.01.10.70.80.90.80.2-0.8
Lifetime Intake3.33.77.2-2.32.42.4-2.1-2.72.52.5-2.6-0.7-0.9-0.9-0.6-1.5-0.2
Liver weight, left0.00.10.3-0.20.20.2-0.3-0.20.20.2-0.2-0.2-0.10.00.0-0.5-0.1
Liver weight, right0.30.62.4-0.30.30.3-0.40.1-0.1-0.20.50.91.11.01.1-1.5-0.7
Locomotor activity1.21.94.1-2.01.81.8-2.0-1.01.20.90.22.01.51.11.2-0.40.0
Locomotor testing distance1.93.17.7-2.42.22.1-2.3-1.11.21.00.62.82.21.71.8-0.6-0.3
Locomotor testing rearing1.42.24.6-2.12.11.9-1.9-1.11.21.00.32.11.71.41.4-0.5-0.3
Locomotion in novel chamber4.55.59.8-2.42.62.6-2.9-2.92.93.1-2.9-1.3-1.8-2.0-1.80.11.6
Locomotion in novel chamber post-restriction2.12.54.7-2.12.02.1-2.1-2.12.22.0-1.7-0.2-0.6-0.8-0.6-0.20.6
Fecal boli incidents, locomotor time 11.41.54.10.4-0.2-0.2-0.1-0.50.60.3-1.4-2.0-2.0-1.9-2.00.81.4
Change in fecal boli incidents, locomotor task1.81.74.4-0.2-0.0-0.00.30.5-0.7-0.51.21.61.82.02.1-1.7-1.8
Time >=10cm from walls, locomotor time 11.41.54.4-0.60.80.8-0.7-1.51.31.4-2.1-1.3-1.3-1.3-1.1-1.4-0.1
Bouts of movement, locomotor time 11.31.45.31.3-1.4-1.51.41.1-0.9-0.80.6-0.7-0.8-0.7-0.92.30.8
Total resting periods, locomotor time 11.01.14.21.1-1.2-1.31.20.7-0.6-0.50.2-0.9-1.0-1.0-1.12.10.8
Rest time, locomotor task time 10.91.02.5-1.21.31.1-1.6-1.21.31.4-0.9-0.1-0.4-0.6-0.50.20.9
Distance moved, locomotor task time 10.20.31.10.2-0.3-0.20.70.2-0.3-0.40.10.30.50.50.5-0.9-1.1
Vertical activity count, locomotor time 10.80.81.9-1.41.21.3-1.2-1.21.21.2-0.7-0.1-0.10.00.1-0.20.1
Time >=10cm from walls, locomotor time 20.40.41.50.3-0.1-0.30.2-0.20.10.5-0.8-0.5-0.8-1.2-1.20.60.5
Bouts of movement, locomotor time 20.40.41.40.7-0.9-0.71.00.6-0.5-0.70.4-0.4-0.3-0.1-0.21.20.1
Total resting periods, locomotor time 20.20.20.90.4-0.6-0.50.80.3-0.3-0.40.2-0.5-0.4-0.2-0.21.00.0
Rest time, locomotor task time 21.51.73.7-1.81.91.6-1.7-1.71.81.8-1.20.2-0.1-0.2-0.1-0.70.1
Distance moved, locomotor task time 20.70.81.51.2-1.2-1.21.11.2-1.2-1.10.90.40.30.0-0.10.6-0.0
Vertical activity count, locomotor time 20.30.30.9-0.2-0.00.2-0.50.4-0.2-0.31.00.90.80.70.70.40.3
Light reinforcement 10.10.10.4-0.50.60.5-0.5-0.30.20.20.10.50.30.10.00.60.3
Light reinforcement 21.92.54.2-0.91.21.0-1.6-1.61.61.6-2.0-1.7-1.8-2.0-2.00.71.8
Bone: marrow area0.81.86.6-1.21.41.4-1.0-1.61.51.5-1.8-0.9-0.7-0.3-0.1-2.6-0.9
Bone: maximum diameter0.61.13.10.8-0.5-0.6-0.1-0.00.20.2-1.0-1.8-1.7-1.6-1.70.01.2
Bone: maximum force1.72.97.12.7-2.6-2.52.51.8-1.8-1.70.3-1.4-0.8-0.5-0.6-1.1-0.8
Bone: maximum moment1.52.56.12.5-2.3-2.32.31.6-1.7-1.60.3-1.3-0.7-0.4-0.5-1.1-0.8
Mean time between licks in bursts1.62.24.10.7-1.0-0.70.81.5-1.5-1.52.02.02.01.91.9-0.7-1.1
Mean num. licks in bursts0.20.20.6-0.50.60.4-0.2-0.10.10.00.40.80.70.70.7-0.0-0.5
Cd content in liver1.92.13.6-1.11.21.2-1.7-1.51.51.3-1.6-1.2-1.5-1.6-1.61.21.9
Co content in liver1.01.23.0-1.51.31.3-1.2-0.60.60.50.71.71.31.01.01.10.3
Cu content in liver0.20.20.90.5-0.5-0.60.90.4-0.5-0.50.3-0.2-0.10.1-0.00.4-0.4
Fe content in liver0.10.10.20.5-0.3-0.40.00.3-0.3-0.3-0.1-0.2-0.2-0.4-0.4-0.20.3
K content in liver1.31.32.71.3-1.3-1.31.61.1-1.2-1.20.70.00.40.70.7-1.5-1.5
Mg content in liver0.50.53.00.2-0.2-0.31.00.1-0.2-0.1-0.1-0.00.20.60.6-1.4-1.7
Mn content in liver1.41.63.82.0-1.8-1.81.41.3-1.3-1.20.2-1.1-1.0-0.9-1.10.60.5
Na content in liver0.60.71.81.3-1.1-1.20.71.0-0.9-0.90.3-0.5-0.4-0.5-0.70.20.6
Rb content in liver0.91.12.4-1.61.51.5-0.8-1.41.21.3-0.80.30.20.40.5-0.7-0.9
Se content in liver1.11.43.60.10.10.0-0.3-0.70.70.8-1.5-1.8-1.9-1.9-1.80.51.1
Sr content in liver2.22.03.92.0-1.9-1.91.31.7-1.6-1.71.1-0.5-0.4-0.6-0.81.61.1
Zn content in liver0.70.72.11.2-1.2-1.21.51.0-1.1-0.90.6-0.4-0.10.0-0.00.3-0.5
Bone: minimum diameter0.81.43.6-1.11.21.2-0.5-1.51.31.4-1.7-1.1-0.8-0.3-0.1-1.9-1.1
Time in familiar zone, hab. session 10.20.20.6-0.50.50.6-0.3-0.60.50.5-0.50.00.00.10.2-0.8-0.5
Time in novel zone, hab. session 10.30.31.2-0.50.30.3-0.50.1-0.1-0.10.71.10.90.80.80.10.1
Total zone transitions, hab. session 10.40.51.51.0-1.0-1.01.20.8-0.9-0.80.5-0.00.10.10.00.2-0.5
Total locomotion distance, hab. session 10.20.31.1-0.60.70.6-0.3-0.70.50.7-0.6-0.1-0.00.10.2-1.0-0.7
Locomotion velocity, hab. session 10.10.10.6-0.10.20.10.2-0.20.10.2-0.3-0.20.00.10.2-0.7-0.7
Time in familiar zone, hab. session 20.91.02.8-0.20.00.2-0.20.6-0.5-0.81.21.71.61.51.5-0.8-0.6
Time in novel zone, hab. session 20.20.20.70.3-0.2-0.30.6-0.10.00.3-0.5-0.8-0.8-0.6-0.70.5-0.0
Total zone transitions, hab. session 21.31.74.31.3-1.3-1.42.11.2-1.5-1.20.80.30.71.01.0-1.5-2.1
Total locomotion distance, hab. session 20.60.83.9-0.10.10.00.70.0-0.3-0.10.10.50.81.01.1-2.0-1.9
Locomotion velocity, hab. session 20.40.63.9-0.20.30.20.4-0.30.10.3-0.40.10.40.60.7-2.0-1.7
Novel to familiar place preference ratio1.31.33.11.3-1.1-1.21.00.4-0.3-0.4-0.7-1.8-1.6-1.5-1.61.00.8
Novelty place preference0.90.92.40.9-0.7-0.80.70.1-0.0-0.0-0.8-1.6-1.4-1.4-1.51.00.7
Time in novel zone, NPP test0.60.61.60.7-0.6-0.60.60.1-0.0-0.1-0.6-1.3-1.2-1.2-1.20.80.6
Total zone transitions, NPP test1.42.04.82.0-1.9-2.02.21.7-1.8-1.71.00.00.30.40.3-0.5-1.1
Total locomotion distance, NPP test0.30.41.70.2-0.2-0.30.70.2-0.4-0.20.20.20.50.70.7-1.2-1.3
Locomotion velocity, NPP test0.20.21.20.3-0.3-0.30.70.2-0.4-0.20.1-0.00.20.40.5-0.8-1.1
Intraocular pressure2.33.16.1-0.91.11.0-1.8-1.51.71.7-1.8-1.7-2.1-2.3-2.21.72.5
Delta distance traveled before/after self-admin0.10.10.4-0.30.00.2-0.20.10.1-0.00.50.00.20.60.70.0-0.1
Delta ambulatory time before/after self-admin0.20.20.9-0.2-0.10.1-0.10.3-0.1-0.30.80.30.61.01.0-0.0-0.3
Parametrial fat weight1.52.95.8-2.12.12.2-1.5-2.42.32.1-2.2-0.7-0.7-0.4-0.2-1.6-0.6
Pavlov. Cond. lever latency0.20.20.5-0.60.50.6-0.7-0.40.50.5-0.10.1-0.0-0.1-0.10.70.6
Pavlov. Cond. magazine entry latency0.20.21.10.5-0.4-0.51.00.2-0.3-0.3-0.2-0.6-0.3-0.2-0.1-0.3-0.8
Pavlov. Cond. change in total contacts0.60.62.00.3-0.2-0.20.5-0.40.40.3-1.0-1.4-1.2-1.2-1.20.60.3
Pavlov. Cond. index score0.10.20.30.5-0.4-0.50.60.2-0.2-0.3-0.2-0.5-0.4-0.5-0.50.30.1
Pavlov. Cond. latency score0.10.10.30.3-0.2-0.30.50.2-0.2-0.3-0.1-0.2-0.1-0.1-0.1-0.2-0.3
Pavlov. Cond. lever contacts0.10.10.40.1-0.1-0.10.30.1-0.2-0.30.10.30.30.30.3-0.6-0.6
Pavlov. Cond. magazine entry number0.50.61.4-0.70.50.7-0.5-0.20.10.20.41.11.01.01.1-1.2-0.8
Pavlov. Cond. intertrial magazine entries0.80.91.3-0.90.71.0-1.1-1.01.21.0-1.0-0.5-0.8-1.0-0.91.11.1
Pavlov. Cond. lever-magazine prob. diff.0.20.30.70.8-0.6-0.80.90.4-0.4-0.5-0.1-0.6-0.4-0.4-0.50.2-0.1
Pavlov. Cond. response bias0.20.20.40.4-0.3-0.40.40.1-0.1-0.1-0.3-0.6-0.5-0.6-0.60.70.3
Pavlov. Cond. lever latency0.40.61.4-1.00.80.9-0.5-0.40.30.20.41.21.11.01.0-0.1-0.5
Pavlov. Cond. magazine entry latency1.92.25.52.2-2.1-2.12.41.8-1.8-1.91.0-0.4-0.10.0-0.20.3-0.6
Pavlov. Cond. change in total contacts1.82.46.11.8-1.6-1.71.50.7-0.5-0.6-0.8-2.5-2.2-1.9-2.01.20.9
Pavlov. Cond. index score1.41.74.02.0-1.8-1.91.71.2-1.1-1.1-0.0-1.5-1.2-1.0-1.20.50.2
Pavlov. Cond. latency score1.11.43.21.8-1.6-1.71.51.0-0.9-0.9-0.1-1.5-1.1-1.0-1.10.20.2
Pavlov. Cond. lever contacts0.50.71.41.0-0.9-0.90.30.4-0.3-0.3-0.3-1.1-1.1-1.1-1.20.61.0
Pavlov. Cond. magazine entry number3.44.19.6-3.13.03.0-3.0-2.32.32.3-1.01.10.60.60.9-1.00.2
Pavlov. Cond. intertrial magazine entries0.70.91.9-1.31.41.3-1.4-1.21.21.2-0.9-0.2-0.3-0.2-0.1-0.40.4
Pavlov. Cond. lever-magazine prob. diff.1.62.04.82.2-2.0-2.12.01.4-1.3-1.40.2-1.4-1.1-0.9-1.10.50.1
Pavlov. Cond. response bias1.11.43.21.8-1.7-1.71.31.1-1.0-1.00.1-1.2-1.0-1.1-1.20.80.6
Time in closed arm before self-admin0.40.41.30.3-0.1-0.20.1-0.20.30.2-0.8-1.0-1.0-1.1-1.10.30.5
Time in closed arm after self-admin0.30.31.0-0.30.00.3-0.1-0.0-0.0-0.10.40.50.70.91.0-1.0-0.9
Time in open arm before self-admin2.02.26.0-1.10.80.8-0.20.1-0.2-0.21.42.52.42.42.4-0.9-1.6
Time in open arm after self-admin0.20.21.1-0.40.40.4-0.4-0.10.20.30.20.50.20.0-0.01.00.5
Bone: periosteal estimation0.40.72.20.10.20.1-0.3-0.60.60.6-1.3-1.5-1.3-1.0-1.0-1.30.1
Bone: periosteal perimeter0.30.52.20.5-0.3-0.30.1-0.20.20.3-0.9-1.5-1.2-1.0-1.0-0.70.3
Bone: post-yield work1.72.38.50.8-0.7-0.61.4-0.60.40.7-2.1-2.9-2.2-1.5-1.3-2.0-1.5
Progressive ratio test 1 active lever presses2.32.44.3-1.92.12.0-2.0-2.12.02.0-1.8-0.2-0.7-0.9-0.80.00.7
Progressive ratio test 1 breakpoint2.12.23.9-1.82.01.9-2.0-1.91.91.9-1.6-0.2-0.6-0.9-0.80.10.8
Progressive ratio test 1 inactive lever presses0.70.81.9-1.41.31.3-1.0-1.21.11.0-0.70.30.10.10.2-0.1-0.1
Progressive ratio test 2 active lever presses4.54.87.9-2.32.52.5-2.6-2.82.72.7-2.8-1.4-1.7-1.8-1.60.11.3
Progressive ratio test 2 breakpoint5.05.69.2-2.72.82.8-3.0-3.03.03.0-2.7-1.1-1.6-1.7-1.50.41.5
Progressive ratio test 2 inactive lever presses7.58.615.3-3.43.53.5-3.4-3.93.83.7-3.6-1.6-2.0-2.1-1.80.21.4
Incentive Sensitization - Responses1.11.12.0-0.70.70.9-0.9-1.21.11.1-1.4-1.4-1.4-1.2-1.10.20.7
Incentive Sensitization - Breakpoint1.41.42.4-0.90.91.1-1.1-1.31.31.3-1.6-1.4-1.5-1.3-1.20.30.9
Sum of active levers in priming session hrs 5-63.23.17.21.5-1.4-1.20.20.6-0.4-0.3-0.7-2.4-2.4-2.5-2.62.12.7
Progressive ratio1.51.75.11.8-1.6-1.72.31.2-1.4-1.40.4-0.20.10.20.2-1.3-1.6
Food seeking constrained by brief footshock0.50.61.30.3-0.5-0.40.40.7-0.6-0.91.10.91.01.21.2-0.4-0.6
Seeking ratio, punishment vs. effort1.11.43.4-1.81.51.6-1.8-0.81.00.90.41.21.01.01.00.50.6
Retroperitoneal fat weight3.511.421.2-4.54.54.6-4.2-4.64.54.5-3.6-0.6-1.0-1.0-0.6-1.60.3
Reaction time number correct0.20.30.90.7-0.5-0.90.20.8-0.8-0.60.70.40.30.10.00.20.4
Reaction time mean minus median1.92.55.62.4-2.2-2.12.01.4-1.5-1.30.0-1.7-1.4-1.4-1.50.80.6
Reaction time mean minus median AUC1.01.33.01.7-1.6-1.51.21.1-1.2-0.90.2-0.9-0.9-1.0-1.10.90.8
Reaction time num false alarms1.11.54.6-0.80.50.8-0.40.1-0.3-0.01.12.21.91.92.0-0.9-1.1
Reaction time num false alarms AUC1.11.64.4-0.1-0.20.10.30.7-0.9-0.71.52.11.91.91.9-0.8-1.2
Reaction time trials correct on left0.20.30.90.7-0.5-0.90.20.8-0.8-0.60.70.40.30.10.00.20.4
Reaction time trials on left0.30.41.10.8-0.6-1.00.30.9-0.8-0.70.80.40.30.10.00.20.4
Reaction time mean0.60.81.90.3-0.3-0.30.2-0.30.20.5-0.8-1.3-1.3-1.4-1.41.10.9
Reaction time mean AUC0.60.92.10.3-0.2-0.20.2-0.40.30.6-1.0-1.4-1.4-1.4-1.41.10.9
Median of all reaction times0.50.61.4-0.20.20.1-0.1-0.60.50.8-1.0-1.1-1.2-1.2-1.10.90.7
Reaction time omissions0.60.92.31.4-1.3-1.51.41.1-1.1-0.90.6-0.2-0.2-0.3-0.30.7-0.0
Reaction time false alarm rate0.81.13.0-0.80.40.9-0.2-0.0-0.2-0.10.91.71.61.61.7-1.0-1.2
Reaction time premature initiation rate3.24.38.01.8-1.8-1.81.92.6-2.6-2.62.82.12.22.11.8-0.3-1.2
Reaction time premature initiations3.85.410.22.4-2.3-2.52.23.1-3.1-3.03.22.12.11.91.60.2-0.7
Std. dev. reaction times0.81.12.01.3-1.2-1.21.00.6-0.7-0.3-0.4-1.4-1.3-1.4-1.41.10.9
Reaction time trials completed0.30.41.10.8-0.6-1.00.30.9-0.8-0.70.80.40.30.10.00.20.4
Reaction time trials AUC0.20.30.70.6-0.4-0.80.20.7-0.7-0.50.70.50.50.30.20.00.3
Run reversals in cocaine runway, females2.92.87.60.4-0.6-0.61.40.9-1.1-1.21.31.72.12.32.3-2.3-2.8
Run reversals in cocaine runway, males0.30.31.4-0.50.50.5-1.2-0.30.50.40.10.50.2-0.1-0.20.51.1
Latency to leave start box in cocaine runway0.20.20.6-0.20.10.30.2-0.40.30.2-0.5-0.6-0.30.00.1-0.8-0.7
Latency to leave start box in cocaine runway, F0.00.10.20.0-0.0-0.00.5-0.20.1-0.1-0.3-0.2-0.2-0.2-0.20.1-0.5
Latency to leave start box in cocaine runway, M0.20.11.2-0.1-0.00.3-0.3-0.20.10.2-0.2-0.5-0.30.20.3-1.1-0.3
Std. dev. time between licks in bursts1.11.34.1-0.40.10.3-0.30.5-0.5-0.41.42.01.81.71.7-0.9-0.9
Total sessions with >9 infusions1.41.53.4-1.61.51.5-1.3-1.51.41.4-1.00.40.30.50.7-1.8-1.0
Short access day 1 total inactive lever presses2.42.75.8-2.42.22.1-2.0-2.32.22.2-1.6-0.3-0.4-0.20.1-0.7-0.0
Short access day 10 total inactive lever presses2.02.25.7-2.42.12.1-1.9-1.71.71.7-0.60.90.70.80.9-0.4-0.3
Short access day 1 total infusions2.02.14.0-2.02.01.8-1.2-2.01.71.8-1.60.0-0.00.10.3-1.7-1.1
Short access day 10 total infusions1.61.75.3-1.41.51.4-0.7-1.71.41.4-1.7-0.5-0.3-0.00.2-2.3-1.4
Short access total infusions1.21.44.1-1.41.51.3-0.9-1.41.21.3-1.20.30.30.30.5-2.0-1.2
Short access day 1 locomotion1.81.93.5-1.91.81.8-1.2-1.71.51.6-1.20.10.20.40.7-1.9-1.0
Short access day 10 total locomotion1.21.42.5-1.61.61.3-0.9-1.61.41.3-1.20.20.20.30.5-1.6-1.1
Short access total locomotion1.21.23.0-1.41.51.2-0.8-1.31.11.2-0.90.50.50.60.7-1.7-1.3
One hour access (0.3 mA shock)7.68.916.0-3.73.83.8-4.0-4.03.93.8-3.4-0.5-1.3-1.7-1.4-0.31.4
Compulsive drug intake3.63.67.31.6-1.8-1.81.92.3-2.2-2.22.72.02.11.91.70.5-1.0
One hour access (shock baseline)9.410.917.6-3.43.63.6-3.9-4.24.04.0-4.2-2.2-2.7-2.9-2.60.22.2
Social response proportion0.50.61.41.2-1.2-1.00.90.8-0.8-0.70.2-0.6-0.4-0.5-0.60.50.3
Social responses0.20.20.50.6-0.6-0.50.30.7-0.7-0.70.60.20.20.10.00.40.3
Social time0.30.40.90.8-0.5-0.90.40.9-0.9-0.70.90.50.50.30.30.20.1
Soleus weight2.36.613.9-3.73.73.7-3.5-3.43.33.3-2.20.2-0.2-0.30.0-0.90.3
Bone: stiffness1.42.35.42.3-2.2-2.22.31.4-1.5-1.30.0-1.7-1.1-0.8-0.9-0.5-0.5
Tibialis anterior weight5.920.145.26.7-6.5-6.65.56.0-5.8-5.93.9-0.30.30.2-0.30.7-0.0
Time to tail flick, vehicle, before self-admin0.30.30.70.8-0.5-0.70.80.5-0.7-0.60.0-0.00.1-0.1-0.1-0.7-0.5
Time to tail flick, vehicle, after self-admin2.22.33.71.2-1.1-1.31.71.5-1.6-1.71.51.21.51.61.5-1.7-1.9
Time to tail flick, test, before self-admin1.41.44.8-1.01.00.8-0.3-0.70.50.5-0.21.41.31.21.3-2.2-1.8
Time to tail flick, test, after self-admin0.00.00.10.2-0.1-0.2-0.00.2-0.2-0.20.20.10.0-0.1-0.10.20.2
Delta time to tail flick, vehicle, before/after SA0.80.81.40.6-0.6-0.70.90.9-0.9-1.01.00.70.91.21.1-0.8-1.2
Delta time to tail flick, test, before/after SA1.71.65.91.3-1.1-1.20.41.1-0.9-0.90.6-0.7-0.9-1.1-1.32.42.0
Tibia length1.33.68.02.1-1.8-1.90.80.8-0.5-0.7-0.9-2.8-2.6-2.7-2.81.52.2
Ambulatory time before self-admin1.11.13.10.9-0.7-0.70.40.0-0.0-0.1-0.9-1.8-1.7-1.6-1.60.81.0
Ambulatory time after self-admin0.91.03.7-0.20.00.3-0.2-0.70.80.7-1.2-1.9-1.7-1.2-1.10.60.6
Bone: tissue strength0.20.20.60.2-0.2-0.10.1-0.20.20.3-0.5-0.8-0.8-0.7-0.70.20.4
Total heroin consumption3.43.98.22.9-2.8-2.82.82.6-2.6-2.61.7-0.20.10.2-0.00.6-0.4
Bone: trabecular number0.40.62.30.9-0.8-0.70.90.1-0.2-0.3-0.7-1.5-1.2-0.8-0.8-0.5-0.2
Bone: trabecular spacing0.40.61.9-0.60.60.5-0.3-0.0-0.0-0.00.71.41.21.11.1-0.1-0.6
Bone: trabecular thickness0.50.61.2-0.80.80.9-0.5-1.11.01.1-1.1-0.8-0.6-0.4-0.3-0.4-0.2
Bone: trabecular tissue density2.23.16.0-2.32.32.4-2.4-2.32.42.2-1.7-0.2-0.7-0.8-0.70.31.0
Water consumed over 24 hours0.60.81.51.0-1.0-1.11.11.1-1.1-1.11.10.30.30.30.11.20.1
Number of responses in last shaping day0.80.81.8-1.41.41.2-1.3-0.91.01.0-0.21.00.60.30.40.00.2