Hub : Genes

Egr3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc alternative TSS NM_017086.2 0.09 0.08 4.8e-11 0.06 0.07 0.07 0.07 4.2e-10 1.6e-10 1.4e-10 1.2e-10
2 NAcc alternative TSS XM_039093001.2 0.08 0.07 5.0e-10 0.06 0.06 0.06 0.06 2.8e-09 1.5e-09 1.4e-09 1.2e-09
3 IC alternative TSS NM_017086.2 0.26 0.2 1.3e-08 0.19 0.17 0.18 0.18 1.9e-08 1.1e-07 7.5e-08 6.1e-08
4 IC alternative TSS XM_039093001.2 0.28 0.21 4.2e-09 0.2 0.19 0.19 0.19 4.9e-09 2.8e-08 2.3e-08 1.7e-08
5 IC intron excision ratio chr15_51561238_51562057 0.07 0.08 8.8e-03 0.01 -0 -0.01 -0 1.6e-01 4.0e-01 6.6e-01 3.8e-01
6 Brain gene expression Egr3 0.04 0.04 2.1e-03 0.02 0.02 0.02 0.01 1.1e-02 8.2e-03 1.1e-02 1.7e-02
7 PL alternative TSS NM_017086.2 0.04 0.04 4.5e-04 0.02 0.02 0.02 0.02 1.5e-03 2.6e-03 3.2e-03 3.4e-03
8 PL alternative TSS XM_039093001.2 0.04 0.04 2.5e-04 0.02 0.02 0.02 0.02 1.1e-03 2.0e-03 2.8e-03 2.4e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density1.22.12.31.5-1.51.5-1.51.41.41.4-1.4
Area under the delay curve0.10.10.2-0.30.3-0.30.3-0.4-0.3-0.30.3
BMI with tail0.41.51.6-1.21.2-1.31.3-1.2-1.2-1.21.2
BMI without tail0.00.00.0-0.00.0-0.10.10.00.00.1-0.1
Body weight0.73.03.1-1.71.7-1.81.8-1.7-1.7-1.81.8
Weight adjusted by age1.42.12.4-1.41.4-1.41.4-1.4-1.5-1.51.5
Bone surface0.61.11.21.1-1.11.1-1.11.11.01.0-1.0
Bone volume0.71.21.31.1-1.11.1-1.11.11.11.1-1.1
Breakpoint value in progressive ratio session0.10.10.2-0.50.5-0.50.5-0.1-0.3-0.30.3
Number of licking bursts0.00.00.0-0.10.10.1-0.10.00.00.0-0.0
Context. condit. distance diff. score0.91.11.11.0-1.01.0-1.01.01.01.1-1.1
Locomotion velocity, session 10.20.20.3-0.50.5-0.50.5-0.4-0.5-0.40.4
Locomotion distance, session 10.00.00.0-0.00.00.1-0.10.20.10.2-0.2
Locomotion velocity, session 20.00.00.10.2-0.20.1-0.10.30.20.2-0.2
Locomotion distance, session 20.00.00.10.1-0.10.1-0.10.30.10.1-0.1
Locomotion velocity, session 30.50.60.7-0.90.9-0.80.8-0.7-0.8-0.70.7
Locomotion distance, session 30.00.00.00.1-0.10.1-0.10.20.20.2-0.2
Stereotopy head waving bouts, day 30.80.91.0-1.01.0-1.01.0-0.9-0.9-0.90.9
Stereotopy head waving duration, day 32.53.03.1-1.81.8-1.71.7-1.7-1.7-1.71.7
Locomotion velocity, session 74.14.54.72.1-2.12.1-2.12.22.12.1-2.1
Locomotion distance, session 73.24.04.42.0-2.02.0-2.02.12.02.0-2.0
Stereotopy head waving bouts, day 71.51.71.9-1.21.2-1.31.3-1.4-1.3-1.41.4
Stereotopy head waving duration, day 72.02.52.8-1.51.5-1.51.5-1.7-1.6-1.61.6
Locomotion velocity, session 80.00.00.0-0.00.0-0.00.00.20.00.0-0.0
Locomotion distance, session 80.60.91.10.9-0.90.9-0.91.11.01.0-1.0
Degree of sensitization distance4.54.64.82.2-2.22.1-2.12.22.12.1-2.1
Degree of sensitization stereotypy1.11.11.3-1.01.0-1.01.0-1.1-1.1-1.11.1
Conditioned locomotion0.00.00.00.2-0.20.2-0.20.20.20.2-0.2
Cocaine response after cond. corrected0.20.30.3-0.50.5-0.60.6-0.5-0.6-0.50.5
Cocaine response after cond. not corrected0.10.20.2-0.40.4-0.40.4-0.4-0.4-0.40.4
Cocaine response before conditioning0.10.20.20.4-0.40.4-0.40.40.40.4-0.4
Saline control response0.10.10.20.4-0.40.3-0.30.40.40.4-0.4
Bone: connectivity density2.53.94.12.0-2.02.0-2.01.92.01.9-1.9
Bone: cortical apparent density0.10.10.10.3-0.30.3-0.30.40.30.3-0.3
Bone: cortical area0.00.00.00.0-0.00.0-0.00.10.0-0.00.0
Bone: cortical porosity1.21.31.3-1.11.1-1.11.1-1.1-1.1-1.11.1
Bone: cortical porosity0.70.70.7-0.90.9-0.90.9-0.8-0.9-0.90.9
Bone: cortical thickness0.00.00.00.0-0.00.0-0.00.20.00.0-0.0
Bone: cortical thickness0.00.00.00.0-0.00.0-0.00.10.00.0-0.0
Bone: cortical tissue density0.10.10.20.3-0.30.3-0.30.40.30.3-0.3
Condit. Reinf. active minus inactive responses0.50.50.6-0.80.8-0.70.7-0.6-0.8-0.70.7
Condit. Reinf. active-inactive response ratio2.22.42.5-1.61.6-1.51.5-1.4-1.6-1.51.5
Condit. Reinf. active responses0.00.00.0-0.10.1-0.10.10.0-0.0-0.00.0
Condit. Reinf. inactive responses2.42.93.11.7-1.71.7-1.71.71.71.7-1.7
Incentive salience index mean0.80.91.0-1.01.0-1.01.0-0.8-1.0-0.90.9
Condit. Reinf. lever presses0.30.40.5-0.70.7-0.70.7-0.5-0.6-0.60.6
Condit. Reinf. active minus inactive responses0.30.40.40.7-0.70.7-0.70.70.70.7-0.7
Condit. Reinf. active-inactive response ratio0.10.10.1-0.30.3-0.20.2-0.2-0.3-0.20.2
Condit. Reinf. active responses0.91.31.31.1-1.11.1-1.11.11.11.1-1.1
Condit. Reinf. inactive responses2.02.62.61.6-1.61.6-1.61.61.61.6-1.6
Condit. Reinf. lever presses0.10.20.20.4-0.40.5-0.50.40.40.4-0.4
Condit. Reinf. lever reinforcers received0.70.91.01.0-1.01.0-1.01.01.01.0-1.0
Conditioned reinforcement - actives1.01.71.81.3-1.31.3-1.31.31.31.3-1.3
Conditioned reinforcement - inactives3.24.74.92.2-2.22.2-2.22.22.22.1-2.1
Conditioned locomotion0.20.20.30.4-0.40.5-0.50.50.40.4-0.4
Patch foraging indifference point 0 sec1.73.23.61.9-1.91.8-1.81.81.81.7-1.7
Patch foraging indifference point AUC0.30.40.5-0.70.7-0.60.6-0.6-0.6-0.50.5
Delay disc. indifference point, 0s delay0.30.40.50.6-0.60.6-0.60.50.60.7-0.7
Delay disc. indifference point, 16s delay0.20.20.20.5-0.50.5-0.50.40.50.4-0.4
Delay disc. indifference point, 2s delay1.51.71.9-1.31.3-1.31.3-1.4-1.3-1.31.3
Delay disc. indifference point, 24s delay0.20.20.4-0.40.4-0.40.4-0.6-0.4-0.50.5
Delay disc. indifference point, 4s delay1.81.91.9-1.41.4-1.41.4-1.4-1.4-1.31.3
Delay disc. indifference point, 8s delay0.00.00.00.1-0.10.1-0.10.00.20.2-0.2
Indifference point function ln k0.00.00.00.2-0.20.1-0.10.00.10.0-0.0
Indifference point function log k0.00.00.00.2-0.20.1-0.10.00.10.0-0.0
Patch foraging total patch changes 0 sec1.22.32.61.6-1.61.5-1.51.41.51.4-1.4
Patch foraging total patch changes 12 sec0.60.80.90.8-0.80.9-0.90.80.90.9-0.9
Patch foraging total patch changes 18 sec1.21.92.11.3-1.31.3-1.31.41.41.4-1.4
Patch foraging total patch changes 24 sec0.00.00.0-0.10.1-0.10.1-0.1-0.0-0.00.0
Patch foraging total patch changes 6 sec0.20.30.30.5-0.50.5-0.50.40.60.6-0.6
Patch foraging time to switch 0 sec0.51.11.21.0-1.01.1-1.11.11.11.0-1.0
Patch foraging water rate 0 sec0.20.50.6-0.60.6-0.70.7-0.8-0.7-0.80.8
Patch foraging water rate 12 sec0.40.91.0-0.90.9-1.01.0-1.0-1.0-1.01.0
Patch foraging water rate 18 sec2.64.14.4-1.91.9-2.02.0-2.1-2.0-2.12.1
Patch foraging water rate 24 sec0.10.20.4-0.30.3-0.40.4-0.6-0.4-0.50.5
Patch foraging water rate 6 sec2.02.92.9-1.71.7-1.71.7-1.7-1.7-1.71.7
Seeking ratio, delayed vs. immediate footshock1.11.41.81.3-1.31.4-1.41.01.11.0-1.0
Distance traveled before self-admin0.60.81.0-0.90.9-0.80.8-0.9-1.0-1.01.0
Distance traveled after self-admin2.43.03.1-1.71.7-1.71.7-1.7-1.8-1.81.8
Extensor digitorum longus weight13.051.252.0-7.27.2-7.27.2-7.1-7.1-7.17.1
Bone: elastic displacement0.40.50.50.7-0.70.7-0.70.70.70.7-0.7
Bone: elastic work0.20.30.30.5-0.50.5-0.50.60.50.5-0.5
Bone: endosteal estimation0.10.10.1-0.30.3-0.30.3-0.4-0.3-0.40.4
Bone: endosteal perimeter0.00.10.1-0.20.2-0.20.2-0.3-0.2-0.30.3
Epididymis fat weight0.72.52.81.6-1.61.5-1.51.71.61.6-1.6
Delta time in closed arm before/after self-admin4.44.14.42.1-2.12.1-2.11.92.02.0-2.0
Delta time in open arm before/after self-admin0.10.10.3-0.50.5-0.20.2-0.2-0.3-0.30.3
Diff in mean of infusions in LGA sessions1.01.21.6-1.31.3-1.11.1-0.7-1.1-1.11.1
Delay discount exponential model param0.40.50.60.7-0.70.7-0.70.80.60.6-0.6
Extinction: sum of active levers before priming2.12.32.61.4-1.41.5-1.51.61.51.5-1.5
Active lever presses in extinction session 60.60.60.80.7-0.70.8-0.80.90.80.8-0.8
Bone: final force0.10.20.2-0.40.4-0.40.4-0.3-0.4-0.40.4
Bone: final moment0.10.10.1-0.30.3-0.30.3-0.3-0.3-0.40.4
Food consumed during 24 hour testing period0.20.30.30.5-0.50.6-0.60.60.60.6-0.6
Glucose0.00.00.0-0.00.00.1-0.10.00.00.0-0.0
Heart weight0.50.70.80.9-0.90.9-0.90.80.80.8-0.8
Delay discount hyperbolic model param0.50.60.70.8-0.80.8-0.80.80.70.7-0.7
Intermittent access intake day 1-15 change1.73.53.71.9-1.91.8-1.81.91.91.9-1.9
Intermittent access intake escalation1.83.73.91.9-1.91.9-1.92.01.91.9-1.9
Intermittent access intake escalation 21.51.71.81.3-1.31.3-1.31.31.31.3-1.3
Intermitt. access day 1 inactive lever presses0.00.00.00.1-0.10.2-0.20.10.10.1-0.1
Intermitt. access day 15 inactive lever presses0.00.10.10.3-0.30.3-0.30.20.20.2-0.2
Intermitt. access escalation Index0.00.10.1-0.30.3-0.30.3-0.2-0.2-0.20.2
Intermittent access day 1 total infusions0.00.00.0-0.00.00.2-0.2-0.0-0.0-0.00.0
Intermittent access day 15 total infusions1.82.73.01.6-1.61.7-1.71.61.61.6-1.6
Intermittent access terminal intake (last 3 days)1.11.51.81.2-1.21.3-1.31.21.21.2-1.2
Intermittent access total infusions1.31.51.71.2-1.21.3-1.31.21.21.2-1.2
Intermittent access day 1 locomotion0.00.00.00.1-0.10.1-0.10.10.10.1-0.1
Intermittent access day 15 total locomotion0.30.50.60.6-0.60.8-0.80.70.60.6-0.6
Intermittent access total locomotion0.10.10.20.3-0.30.4-0.40.40.30.3-0.3
Intermittent access standard deviation0.10.30.40.5-0.50.5-0.50.60.60.5-0.5
Left kidney weight0.00.20.2-0.40.4-0.40.4-0.5-0.4-0.50.5
Right kidney weight0.00.10.1-0.20.2-0.30.3-0.3-0.3-0.30.3
Cocaine induced anxiety0.00.00.0-0.10.1-0.00.0-0.0-0.1-0.00.0
Post-drug Anxiety0.90.91.00.9-0.91.0-1.01.01.01.0-1.0
Baseline Anxiety0.40.50.50.6-0.60.7-0.70.70.70.7-0.7
Tail length0.51.82.01.4-1.41.3-1.31.41.41.4-1.4
Length with tail0.00.20.2-0.40.4-0.40.4-0.5-0.4-0.50.5
Length without tail2.27.17.6-2.62.6-2.62.6-2.7-2.7-2.72.7
Times rat made contact with spout0.50.60.70.7-0.70.8-0.80.80.80.8-0.8
Lifetime Intake0.80.91.10.9-0.91.1-1.11.00.90.9-0.9
Liver weight, left1.93.23.5-1.81.8-1.91.9-1.8-1.7-1.71.7
Liver weight, right0.50.91.1-0.90.9-1.01.0-0.9-0.9-0.90.9
Locomotor activity1.52.32.6-1.51.5-1.41.4-1.6-1.6-1.61.6
Locomotor testing distance0.00.10.10.3-0.30.3-0.30.20.20.2-0.2
Locomotor testing rearing0.10.30.30.6-0.60.5-0.50.40.50.5-0.5
Locomotion in novel chamber0.50.70.80.9-0.90.8-0.80.80.80.8-0.8
Locomotion in novel chamber post-restriction0.61.01.3-0.90.9-0.80.8-1.2-1.1-1.11.1
Fecal boli incidents, locomotor time 11.11.61.8-1.31.3-1.31.3-1.1-1.2-1.21.2
Change in fecal boli incidents, locomotor task0.20.20.3-0.40.4-0.40.4-0.5-0.5-0.50.5
Time >=10cm from walls, locomotor time 10.91.01.20.9-0.90.9-0.91.11.01.0-1.0
Bouts of movement, locomotor time 14.85.45.9-2.42.4-2.42.4-2.3-2.3-2.12.1
Total resting periods, locomotor time 14.85.35.7-2.42.4-2.42.4-2.3-2.3-2.12.1
Rest time, locomotor task time 11.92.42.5-1.61.6-1.61.6-1.6-1.5-1.41.4
Distance moved, locomotor task time 12.23.33.71.8-1.81.8-1.81.91.81.7-1.7
Vertical activity count, locomotor time 10.51.21.41.2-1.21.2-1.21.01.11.0-1.0
Time >=10cm from walls, locomotor time 20.30.40.6-0.60.6-0.60.6-0.8-0.7-0.60.6
Bouts of movement, locomotor time 23.25.25.4-2.32.3-2.32.3-2.3-2.3-2.22.2
Total resting periods, locomotor time 23.25.65.7-2.42.4-2.42.4-2.4-2.4-2.32.3
Rest time, locomotor task time 20.91.11.6-1.01.0-1.01.0-1.3-1.1-1.01.0
Distance moved, locomotor task time 23.03.63.91.9-1.91.9-1.92.01.91.8-1.8
Vertical activity count, locomotor time 20.40.50.60.7-0.70.7-0.70.70.70.7-0.7
Light reinforcement 12.15.15.52.3-2.32.3-2.32.32.32.2-2.2
Light reinforcement 20.81.21.31.1-1.11.1-1.11.21.11.1-1.1
Bone: marrow area0.00.00.1-0.20.2-0.20.2-0.2-0.2-0.20.2
Bone: maximum diameter0.30.60.7-0.80.8-0.80.8-0.7-0.8-0.80.8
Bone: maximum force0.30.50.5-0.70.7-0.70.7-0.6-0.7-0.70.7
Bone: maximum moment0.20.30.3-0.50.5-0.50.5-0.4-0.5-0.60.6
Mean time between licks in bursts1.12.62.71.6-1.61.7-1.71.61.61.6-1.6
Mean num. licks in bursts0.20.30.40.6-0.60.5-0.50.60.60.6-0.6
Cd content in liver1.21.31.4-1.21.2-1.11.1-1.1-1.1-1.11.1
Co content in liver5.05.96.1-2.52.5-2.42.4-2.4-2.4-2.42.4
Cu content in liver0.40.50.5-0.70.7-0.70.7-0.6-0.7-0.60.6
Fe content in liver1.72.02.11.4-1.41.4-1.41.41.41.4-1.4
K content in liver1.21.11.21.1-1.11.1-1.11.11.11.1-1.1
Mg content in liver2.72.82.81.7-1.71.7-1.71.71.71.7-1.7
Mn content in liver2.52.82.81.7-1.71.7-1.71.71.71.7-1.7
Na content in liver0.91.01.1-1.01.0-1.01.0-1.0-1.0-1.01.0
Rb content in liver0.00.00.10.2-0.20.2-0.20.20.20.2-0.2
Se content in liver1.01.21.21.1-1.11.1-1.11.11.11.1-1.1
Sr content in liver0.00.00.00.1-0.10.1-0.10.20.10.2-0.2
Zn content in liver0.10.10.20.3-0.30.4-0.40.40.40.4-0.4
Bone: minimum diameter0.10.20.3-0.40.4-0.50.5-0.5-0.5-0.50.5
Time in familiar zone, hab. session 10.00.00.0-0.10.1-0.10.1-0.1-0.2-0.20.2
Time in novel zone, hab. session 11.21.21.3-1.11.1-1.11.1-1.1-1.1-1.11.1
Total zone transitions, hab. session 10.20.30.4-0.60.6-0.60.6-0.4-0.5-0.50.5
Total locomotion distance, hab. session 10.00.00.0-0.10.1-0.00.00.10.00.1-0.1
Locomotion velocity, hab. session 10.10.10.20.2-0.20.3-0.30.40.30.4-0.4
Time in familiar zone, hab. session 22.02.12.2-1.51.5-1.51.5-1.3-1.5-1.51.5
Time in novel zone, hab. session 20.70.70.80.9-0.90.9-0.90.70.90.9-0.9
Total zone transitions, hab. session 21.41.81.8-1.41.4-1.31.3-1.3-1.3-1.31.3
Total locomotion distance, hab. session 20.20.30.4-0.60.6-0.60.6-0.5-0.5-0.50.5
Locomotion velocity, hab. session 20.60.80.8-0.90.9-0.90.9-0.8-0.9-0.80.8
Novel to familiar place preference ratio1.51.61.71.3-1.31.3-1.31.11.31.3-1.3
Novelty place preference1.21.31.31.2-1.21.2-1.21.01.11.1-1.1
Time in novel zone, NPP test0.60.70.70.8-0.80.8-0.80.70.80.8-0.8
Total zone transitions, NPP test0.10.20.30.4-0.40.4-0.40.50.50.5-0.5
Total locomotion distance, NPP test2.53.53.71.8-1.81.9-1.91.91.91.9-1.9
Locomotion velocity, NPP test2.43.43.61.8-1.81.8-1.81.91.91.9-1.9
Intraocular pressure0.50.70.80.8-0.80.9-0.90.90.80.8-0.8
Delta distance traveled before/after self-admin3.23.43.6-1.91.9-1.91.9-1.8-1.8-1.81.8
Delta ambulatory time before/after self-admin2.83.53.7-1.91.9-1.91.9-1.9-1.8-1.81.8
Parametrial fat weight1.94.54.82.2-2.22.2-2.22.02.12.0-2.0
Pavlov. Cond. lever latency0.00.00.00.0-0.00.0-0.0-0.10.00.0-0.0
Pavlov. Cond. magazine entry latency0.00.00.10.1-0.10.1-0.10.30.20.2-0.2
Pavlov. Cond. change in total contacts1.21.31.4-1.21.2-1.21.2-1.0-1.1-1.11.1
Pavlov. Cond. index score0.10.10.1-0.30.3-0.30.3-0.1-0.3-0.30.3
Pavlov. Cond. latency score0.00.00.1-0.20.2-0.20.2-0.0-0.2-0.20.2
Pavlov. Cond. lever contacts0.00.00.10.0-0.00.1-0.10.20.10.1-0.1
Pavlov. Cond. magazine entry number0.40.50.50.7-0.70.7-0.70.60.70.7-0.7
Pavlov. Cond. intertrial magazine entries0.10.10.10.4-0.40.4-0.40.30.40.4-0.4
Pavlov. Cond. lever-magazine prob. diff.0.20.20.3-0.50.5-0.50.5-0.3-0.5-0.50.5
Pavlov. Cond. response bias0.20.20.2-0.50.5-0.50.5-0.3-0.4-0.40.4
Pavlov. Cond. lever latency0.40.50.60.8-0.80.7-0.70.70.70.7-0.7
Pavlov. Cond. magazine entry latency0.10.10.10.2-0.20.3-0.30.30.30.3-0.3
Pavlov. Cond. change in total contacts1.21.92.1-1.41.4-1.31.3-1.4-1.4-1.41.4
Pavlov. Cond. index score0.40.50.6-0.80.8-0.60.6-0.7-0.7-0.70.7
Pavlov. Cond. latency score0.20.30.4-0.60.6-0.50.5-0.6-0.6-0.60.6
Pavlov. Cond. lever contacts0.20.20.3-0.60.6-0.40.4-0.5-0.5-0.50.5
Pavlov. Cond. magazine entry number0.00.00.0-0.10.1-0.20.2-0.2-0.2-0.20.2
Pavlov. Cond. intertrial magazine entries5.27.87.82.8-2.82.8-2.82.82.82.8-2.8
Pavlov. Cond. lever-magazine prob. diff.0.50.60.8-0.90.9-0.70.7-0.8-0.8-0.80.8
Pavlov. Cond. response bias0.20.30.4-0.60.6-0.50.5-0.5-0.5-0.50.5
Time in closed arm before self-admin1.72.22.3-1.51.5-1.51.5-1.5-1.4-1.51.5
Time in closed arm after self-admin0.00.00.1-0.10.1-0.10.1-0.3-0.2-0.20.2
Time in open arm before self-admin0.00.00.00.1-0.10.1-0.10.10.00.1-0.1
Time in open arm after self-admin0.00.00.10.0-0.00.1-0.10.20.20.2-0.2
Bone: periosteal estimation0.00.10.1-0.20.2-0.20.2-0.2-0.3-0.30.3
Bone: periosteal perimeter0.00.00.1-0.10.1-0.20.2-0.3-0.2-0.20.2
Bone: post-yield work0.10.20.20.5-0.50.4-0.40.50.40.4-0.4
Progressive ratio test 1 active lever presses0.10.10.1-0.30.3-0.30.3-0.3-0.3-0.30.3
Progressive ratio test 1 breakpoint0.10.20.2-0.40.4-0.30.3-0.4-0.4-0.40.4
Progressive ratio test 1 inactive lever presses0.91.31.71.1-1.11.3-1.31.11.11.1-1.1
Progressive ratio test 2 active lever presses0.00.00.10.2-0.20.3-0.30.20.20.2-0.2
Progressive ratio test 2 breakpoint0.00.00.10.2-0.20.3-0.30.20.10.1-0.1
Progressive ratio test 2 inactive lever presses0.30.50.60.7-0.70.8-0.80.70.70.6-0.6
Incentive Sensitization - Responses0.30.40.40.6-0.60.6-0.60.60.60.6-0.6
Incentive Sensitization - Breakpoint0.40.50.50.7-0.70.7-0.70.70.70.7-0.7
Sum of active levers in priming session hrs 5-60.10.10.20.3-0.30.3-0.30.40.30.3-0.3
Progressive ratio0.00.00.0-0.10.1-0.10.1-0.1-0.1-0.10.1
Food seeking constrained by brief footshock2.02.52.7-1.61.6-1.51.5-1.6-1.6-1.61.6
Seeking ratio, punishment vs. effort0.71.01.1-1.01.0-0.90.9-1.0-1.0-1.01.0
Retroperitoneal fat weight0.10.40.50.7-0.70.6-0.60.70.70.6-0.6
Reaction time number correct0.51.01.1-1.01.0-1.01.0-1.0-1.0-1.01.0
Reaction time mean minus median0.10.20.2-0.50.5-0.30.3-0.4-0.4-0.40.4
Reaction time mean minus median AUC0.00.10.2-0.40.4-0.30.3-0.3-0.3-0.30.3
Reaction time num false alarms0.10.10.2-0.30.3-0.30.3-0.4-0.4-0.40.4
Reaction time num false alarms AUC0.00.10.1-0.20.2-0.20.2-0.3-0.3-0.40.4
Reaction time trials correct on left0.51.01.1-1.01.0-1.01.0-1.0-1.0-1.01.0
Reaction time trials on left0.40.80.8-0.90.9-0.90.9-0.9-0.9-0.80.8
Reaction time mean0.20.30.4-0.60.6-0.50.5-0.4-0.5-0.40.4
Reaction time mean AUC0.30.50.6-0.80.8-0.70.7-0.6-0.7-0.60.6
Median of all reaction times0.20.20.3-0.50.5-0.50.5-0.3-0.4-0.40.4
Reaction time omissions1.72.52.61.6-1.61.6-1.61.61.61.6-1.6
Reaction time false alarm rate0.10.10.10.4-0.40.4-0.40.30.30.2-0.2
Reaction time premature initiation rate1.82.62.7-1.51.5-1.61.6-1.5-1.6-1.61.6
Reaction time premature initiations2.13.83.9-1.91.9-2.02.0-1.9-2.0-2.02.0
Std. dev. reaction times0.10.20.3-0.50.5-0.40.4-0.4-0.4-0.40.4
Reaction time trials completed0.40.80.8-0.90.9-0.90.9-0.9-0.9-0.80.8
Reaction time trials AUC0.40.70.8-0.90.9-0.80.8-0.9-0.8-0.80.8
Run reversals in cocaine runway, females3.03.03.31.7-1.71.7-1.71.81.81.7-1.7
Run reversals in cocaine runway, males2.22.22.7-1.41.4-1.61.6-1.4-1.4-1.41.4
Latency to leave start box in cocaine runway0.40.50.6-0.70.7-0.50.5-0.7-0.7-0.80.8
Latency to leave start box in cocaine runway, F1.31.51.7-1.21.2-1.21.2-1.3-1.2-1.31.3
Latency to leave start box in cocaine runway, M0.10.10.30.3-0.30.6-0.60.30.30.3-0.3
Std. dev. time between licks in bursts1.31.71.71.3-1.31.3-1.31.31.31.3-1.3
Total sessions with >9 infusions0.00.00.1-0.20.2-0.20.2-0.2-0.2-0.20.2
Short access day 1 total inactive lever presses0.10.20.20.5-0.50.5-0.50.40.40.4-0.4
Short access day 10 total inactive lever presses0.10.30.40.5-0.50.6-0.60.40.50.5-0.5
Short access day 1 total infusions0.00.10.1-0.20.2-0.20.2-0.2-0.3-0.30.3
Short access day 10 total infusions0.30.30.4-0.60.6-0.50.5-0.6-0.6-0.60.6
Short access total infusions0.00.00.1-0.20.2-0.10.1-0.2-0.2-0.20.2
Short access day 1 locomotion0.81.01.1-1.01.0-0.90.9-1.0-1.0-1.01.0
Short access day 10 total locomotion0.00.00.00.1-0.10.0-0.0-0.10.00.1-0.1
Short access total locomotion0.10.10.1-0.30.3-0.40.4-0.3-0.4-0.40.4
One hour access (0.3 mA shock)0.70.80.90.9-0.90.9-0.90.90.90.9-0.9
Compulsive drug intake0.60.70.80.9-0.90.7-0.70.80.80.9-0.9
One hour access (shock baseline)0.00.00.0-0.00.00.1-0.10.10.0-0.00.0
Social response proportion0.10.10.2-0.30.3-0.40.4-0.3-0.3-0.40.4
Social responses1.11.41.41.2-1.21.1-1.11.21.21.2-1.2
Social time0.40.50.70.8-0.80.7-0.70.80.70.6-0.6
Soleus weight1.33.73.8-1.91.9-1.91.9-1.9-1.9-1.91.9
Bone: stiffness0.71.11.2-1.01.0-1.11.1-0.9-1.1-1.11.1
Tibialis anterior weight8.428.429.3-5.45.4-5.35.3-5.3-5.3-5.35.3
Time to tail flick, vehicle, before self-admin1.11.11.41.0-1.01.2-1.21.11.01.0-1.0
Time to tail flick, vehicle, after self-admin1.41.91.9-1.41.4-1.41.4-1.3-1.4-1.41.4
Time to tail flick, test, before self-admin3.03.13.71.7-1.71.7-1.71.91.81.8-1.8
Time to tail flick, test, after self-admin2.42.52.91.7-1.71.5-1.51.51.61.6-1.6
Delta time to tail flick, vehicle, before/after SA0.30.30.4-0.50.5-0.60.6-0.6-0.5-0.50.5
Delta time to tail flick, test, before/after SA0.00.00.00.2-0.20.1-0.1-0.10.10.1-0.1
Tibia length1.23.43.61.9-1.91.8-1.81.91.81.8-1.8
Ambulatory time before self-admin0.20.30.3-0.60.6-0.50.5-0.5-0.6-0.60.6
Ambulatory time after self-admin5.26.26.3-2.52.5-2.52.5-2.5-2.5-2.52.5
Bone: tissue strength0.10.10.10.3-0.30.2-0.20.20.20.2-0.2
Total heroin consumption0.60.70.9-0.90.9-0.90.9-0.6-0.8-0.80.8
Bone: trabecular number2.23.73.92.0-2.02.0-2.01.91.91.9-1.9
Bone: trabecular spacing2.33.03.1-1.81.8-1.71.7-1.8-1.7-1.71.7
Bone: trabecular thickness1.11.41.51.2-1.21.2-1.21.21.21.2-1.2
Bone: trabecular tissue density1.32.02.1-1.41.4-1.41.4-1.4-1.4-1.41.4
Water consumed over 24 hours1.31.71.9-1.41.4-1.31.3-1.3-1.3-1.31.3
Number of responses in last shaping day0.60.60.7-0.80.8-0.80.8-0.7-0.8-0.80.8