Hub : Genes

Fabp4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Fabp4 0.15 0.07 0.0e+00 0.17 0.16 0.17 0.17 8.1e-25 7.4e-24 4.2e-25 1.1e-24
2 IL gene expression Fabp4 0.71 0.16 5.9e-07 0.04 0.06 0.05 0.04 3.8e-02 1.3e-02 2.8e-02 3.8e-02
3 Adipose alternative TSS XM_063282611.1 0.17 0.1 1.1e-15 0.11 0.1 0.1 0.1 6.5e-12 1.4e-11 1.1e-11 1.9e-11
4 Adipose mRNA stability Fabp4 0.08 0.05 6.7e-08 0.04 0.04 0.04 0.04 1.0e-05 5.2e-05 5.4e-05 8.6e-05
5 PL gene expression Fabp4 0.44 0.14 0.0e+00 0.33 0.32 0.34 0.33 8.4e-37 8.2e-36 8.0e-38 3.5e-37
6 IC gene expression Fabp4 0.1 0.07 1.7e-03 0.05 0.04 0.01 0.04 3.2e-03 9.9e-03 7.5e-02 6.6e-03
7 OFC gene expression Fabp4 0.41 0.18 3.7e-05 0.14 0.11 0.07 0.11 4.3e-04 1.5e-03 1.1e-02 1.4e-03
8 Brain gene expression Fabp4 0.18 0.1 2.3e-12 0.1 0.08 0.09 0.09 1.9e-09 4.7e-08 2.1e-08 5.3e-09
9 BLA gene expression Fabp4 0.42 0.15 0.0e+00 0.26 0.25 0.26 0.27 3.1e-14 1.2e-13 4.6e-14 1.0e-14
10 Adipose alternative TSS NM_053365.3 0.18 0.11 5.0e-16 0.11 0.11 0.11 0.11 3.7e-12 8.1e-12 7.5e-12 8.9e-12
11 pVTA gene expression Fabp4 0.1 0.06 1.3e-07 0.08 0.09 0.11 0.08 3.4e-07 1.1e-07 3.0e-09 7.8e-07
12 Adipose gene expression Fabp4 0.05 0.04 2.1e-03 0.02 0.02 0.01 0.02 2.1e-03 2.5e-03 1.5e-02 4.1e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density1.01.82.6-1.6-1.4-1.3-1.3-1.5-1.5-1.3-1.4-1.41.3-1.2-0.6
Area under the delay curve0.60.81.00.80.90.90.91.01.00.90.80.9-0.90.70.5
BMI with tail0.72.53.41.81.71.61.61.71.61.41.61.7-1.51.8-0.8
BMI without tail1.23.64.22.02.11.81.82.01.91.92.02.0-1.92.1-1.3
Body weight1.25.26.32.42.52.32.32.32.22.42.22.1-2.02.5-2.0
Weight adjusted by age0.20.30.50.40.30.20.20.50.50.60.50.7-0.70.7-0.6
Bone surface1.83.24.5-2.1-1.7-1.8-1.8-1.8-1.8-1.7-1.9-1.71.7-1.4-1.8
Bone volume1.62.83.9-2.0-1.7-1.7-1.7-1.8-1.8-1.6-1.6-1.51.4-1.3-1.9
Breakpoint value in progressive ratio session0.81.01.50.71.01.01.01.01.10.91.21.1-1.00.9-0.6
Number of licking bursts0.30.50.7-0.8-0.7-0.6-0.6-0.8-0.8-0.8-0.6-0.60.7-0.60.0
Context. condit. distance diff. score0.10.10.30.30.40.30.30.20.20.1-0.1-0.0-0.1-0.00.5
Locomotion velocity, session 12.52.73.31.81.81.81.81.71.71.71.61.6-1.61.7-0.3
Locomotion distance, session 11.31.62.01.21.41.31.31.21.21.31.21.2-1.21.4-1.1
Locomotion velocity, session 22.42.83.21.81.71.71.71.71.71.71.81.8-1.81.7-0.5
Locomotion distance, session 21.72.43.71.41.51.51.51.41.41.51.61.5-1.51.7-1.9
Locomotion velocity, session 30.00.00.30.10.00.10.10.00.00.10.0-0.0-0.0-0.00.5
Locomotion distance, session 30.20.20.3-0.6-0.5-0.5-0.5-0.5-0.5-0.5-0.3-0.50.4-0.3-0.4
Stereotopy head waving bouts, day 30.10.21.00.20.40.20.20.30.30.30.20.3-0.40.4-1.0
Stereotopy head waving duration, day 30.40.50.70.80.80.80.80.80.80.70.60.8-0.80.7-0.3
Locomotion velocity, session 73.94.36.1-2.5-1.9-1.8-1.8-2.2-2.2-2.1-2.2-2.22.2-1.8-2.0
Locomotion distance, session 74.65.87.9-2.8-2.4-2.3-2.3-2.6-2.6-2.5-2.7-2.62.6-2.5-0.5
Stereotopy head waving bouts, day 70.91.01.41.11.00.90.91.11.11.01.11.1-1.11.2-0.7
Stereotopy head waving duration, day 71.21.41.91.31.21.11.11.31.31.21.31.2-1.21.4-0.3
Locomotion velocity, session 84.04.86.12.52.42.32.32.32.32.32.12.2-2.22.2-0.2
Locomotion distance, session 81.31.93.01.51.71.61.61.51.51.41.11.2-1.31.3-0.8
Degree of sensitization distance0.40.40.7-0.7-0.5-0.5-0.5-0.7-0.7-0.6-0.8-0.70.7-0.8-0.1
Degree of sensitization stereotypy2.02.12.61.61.41.41.41.61.61.41.61.5-1.51.6-0.5
Conditioned locomotion0.20.20.30.50.40.50.50.40.40.40.50.4-0.50.5-0.2
Cocaine response after cond. corrected0.70.91.1-1.0-0.9-1.0-1.0-1.0-1.0-0.9-1.0-0.90.9-1.00.4
Cocaine response after cond. not corrected1.41.72.2-1.4-1.4-1.5-1.5-1.3-1.4-1.2-1.3-1.21.2-1.30.5
Cocaine response before conditioning0.20.30.5-0.6-0.7-0.7-0.7-0.5-0.5-0.5-0.4-0.40.5-0.3-0.2
Saline control response0.30.41.7-0.6-0.6-0.6-0.6-0.5-0.5-0.5-0.6-0.50.5-0.3-1.3
Bone: connectivity density1.62.43.3-1.8-1.4-1.4-1.4-1.6-1.7-1.6-1.8-1.81.7-1.6-0.3
Bone: cortical apparent density0.91.21.91.31.21.41.41.11.11.01.21.0-0.91.00.4
Bone: cortical area0.20.41.90.30.10.20.20.30.30.60.50.8-0.70.7-1.4
Bone: cortical porosity0.10.10.3-0.2-0.3-0.3-0.3-0.1-0.1-0.2-0.1-0.00.10.0-0.5
Bone: cortical porosity0.10.10.40.10.00.00.00.20.20.10.20.3-0.30.3-0.6
Bone: cortical thickness0.71.12.00.80.80.90.90.90.91.11.11.2-1.21.2-1.4
Bone: cortical thickness4.25.06.92.31.92.22.22.22.22.52.52.6-2.62.3-0.7
Bone: cortical tissue density0.91.21.91.31.21.41.41.11.11.01.21.0-0.91.00.5
Condit. Reinf. active minus inactive responses5.76.48.32.52.42.42.42.42.42.52.72.6-2.62.9-2.6
Condit. Reinf. active-inactive response ratio7.47.910.22.72.72.62.62.82.82.82.92.8-2.83.2-2.8
Condit. Reinf. active responses4.45.57.42.22.22.22.22.22.22.32.42.4-2.32.7-2.7
Condit. Reinf. inactive responses0.00.10.10.20.20.20.20.20.20.30.20.2-0.30.2-0.3
Incentive salience index mean5.97.29.32.62.62.62.62.62.62.72.82.7-2.73.0-2.7
Condit. Reinf. lever presses2.73.84.62.02.02.12.11.91.91.91.91.9-1.92.2-1.7
Condit. Reinf. active minus inactive responses1.62.14.4-1.7-1.4-1.6-1.6-1.4-1.3-1.3-1.3-1.21.3-1.0-2.1
Condit. Reinf. active-inactive response ratio0.80.93.4-1.1-0.8-1.0-1.0-0.8-0.8-0.8-0.7-0.70.8-0.5-1.8
Condit. Reinf. active responses2.33.34.8-2.1-1.8-2.0-2.0-1.7-1.7-1.6-1.7-1.61.7-1.3-2.2
Condit. Reinf. inactive responses0.10.20.3-0.4-0.3-0.5-0.5-0.4-0.3-0.3-0.6-0.40.4-0.3-0.6
Condit. Reinf. lever presses1.01.42.1-1.5-1.2-1.1-1.1-1.3-1.3-1.1-1.1-0.91.1-0.9-1.5
Condit. Reinf. lever reinforcers received2.53.44.7-2.2-1.9-2.1-2.1-1.8-1.8-1.7-1.8-1.61.7-1.4-2.1
Conditioned reinforcement - actives3.66.28.5-2.9-2.3-2.2-2.2-2.8-2.7-2.9-2.7-2.72.6-2.1-1.0
Conditioned reinforcement - inactives0.20.30.6-0.7-0.5-0.6-0.6-0.4-0.5-0.8-0.5-0.50.4-0.5-0.5
Conditioned locomotion2.22.94.8-1.8-1.5-1.3-1.3-2.0-2.0-2.2-2.0-1.91.9-1.2-0.8
Patch foraging indifference point 0 sec0.81.52.0-1.2-1.4-1.2-1.2-1.1-1.0-1.2-1.3-1.10.9-1.41.3
Patch foraging indifference point AUC0.10.20.40.60.40.50.50.40.30.60.50.4-0.50.40.2
Delay disc. indifference point, 0s delay0.10.10.3-0.1-0.2-0.2-0.2-0.4-0.3-0.5-0.6-0.50.4-0.20.4
Delay disc. indifference point, 16s delay0.50.60.80.60.80.80.80.90.90.90.80.9-0.80.30.3
Delay disc. indifference point, 2s delay1.01.22.50.91.11.21.20.91.01.00.90.8-0.91.2-1.6
Delay disc. indifference point, 24s delay0.10.10.20.10.20.10.10.40.40.40.30.5-0.30.00.3
Delay disc. indifference point, 4s delay1.71.82.21.41.41.41.41.41.51.41.31.3-1.41.30.3
Delay disc. indifference point, 8s delay0.10.11.00.1-0.1-0.1-0.10.20.20.10.10.3-0.10.11.0
Indifference point function ln k0.00.00.10.10.30.20.20.20.30.0-0.10.0-0.1-0.00.4
Indifference point function log k0.00.00.10.10.30.20.20.20.30.0-0.10.0-0.1-0.00.4
Patch foraging total patch changes 0 sec0.50.92.1-0.9-1.0-0.9-0.9-0.8-0.7-0.8-1.0-0.80.6-1.21.5
Patch foraging total patch changes 12 sec0.30.41.4-0.4-0.7-0.6-0.6-0.5-0.4-0.5-0.6-0.50.3-0.71.2
Patch foraging total patch changes 18 sec0.40.51.20.70.50.60.60.60.70.90.80.9-1.10.50.6
Patch foraging total patch changes 24 sec0.10.10.9-0.0-0.10.10.1-0.2-0.2-0.1-0.3-0.30.1-0.31.0
Patch foraging total patch changes 6 sec0.10.11.20.2-0.1-0.0-0.00.20.20.10.00.1-0.3-0.21.1
Patch foraging time to switch 0 sec1.22.54.91.21.61.51.51.61.61.41.51.6-1.51.7-2.2
Patch foraging water rate 0 sec0.20.32.6-0.1-0.4-0.4-0.4-0.3-0.3-0.2-0.3-0.40.4-0.71.6
Patch foraging water rate 12 sec1.22.43.2-1.7-1.7-1.7-1.7-1.5-1.6-1.4-1.6-1.51.5-1.81.0
Patch foraging water rate 18 sec0.30.50.6-0.6-0.7-0.8-0.8-0.7-0.7-0.7-0.7-0.70.7-0.60.2
Patch foraging water rate 24 sec0.10.21.70.0-0.1-0.3-0.3-0.2-0.2-0.0-0.3-0.10.4-0.51.3
Patch foraging water rate 6 sec2.23.23.6-1.9-1.9-1.8-1.8-1.9-1.8-1.7-1.9-1.91.9-1.90.8
Seeking ratio, delayed vs. immediate footshock8.210.011.7-3.1-3.4-3.3-3.3-3.3-3.2-3.3-3.4-3.33.4-3.21.4
Distance traveled before self-admin0.50.61.10.81.01.11.10.80.70.70.70.7-0.80.70.1
Distance traveled after self-admin0.10.10.2-0.3-0.3-0.4-0.4-0.2-0.3-0.3-0.3-0.30.3-0.40.4
Extensor digitorum longus weight11.444.753.77.17.37.27.27.17.16.96.56.6-6.76.6-2.7
Bone: elastic displacement0.20.32.60.10.30.20.20.20.30.20.30.2-0.30.5-1.6
Bone: elastic work0.20.33.0-0.2-0.0-0.1-0.1-0.0-0.00.00.10.1-0.10.4-1.7
Bone: endosteal estimation0.40.94.1-1.0-0.7-0.9-0.9-0.8-0.8-0.8-0.8-0.70.7-0.4-2.0
Bone: endosteal perimeter0.40.81.0-1.0-0.9-1.0-1.0-0.9-0.9-0.9-0.9-0.81.0-0.7-0.8
Epididymis fat weight0.41.22.01.31.41.41.41.01.01.21.20.9-0.91.00.1
Delta time in closed arm before/after self-admin0.10.10.60.4-0.10.00.0-0.4-0.3-0.3-0.4-0.40.30.10.7
Delta time in open arm before/after self-admin0.20.20.5-0.7-0.4-0.5-0.5-0.2-0.3-0.3-0.5-0.40.2-0.6-0.1
Diff in mean of infusions in LGA sessions1.61.92.80.91.41.31.31.41.51.41.51.5-1.51.1-1.7
Delay discount exponential model param0.50.60.8-0.7-0.8-0.8-0.8-0.9-0.9-0.8-0.8-0.80.8-0.6-0.5
Extinction: sum of active levers before priming0.10.20.30.30.10.30.30.30.40.50.60.5-0.40.6-0.4
Active lever presses in extinction session 60.20.20.6-0.5-0.5-0.4-0.4-0.4-0.2-0.3-0.0-0.20.3-0.40.8
Bone: final force0.30.53.00.40.30.20.20.40.40.60.60.8-0.70.9-1.7
Bone: final moment0.20.32.7-0.0-0.1-0.1-0.10.10.10.20.20.4-0.30.4-1.6
Food consumed during 24 hour testing period1.82.42.81.71.61.51.51.61.61.61.71.6-1.61.6-0.7
Glucose1.21.92.71.41.31.21.21.51.51.51.51.7-1.51.4-0.6
Heart weight0.30.50.70.90.60.70.70.70.70.70.80.6-0.50.60.6
Delay discount hyperbolic model param1.01.11.4-1.0-1.1-1.1-1.1-1.1-1.2-1.1-1.0-1.11.1-1.0-0.1
Intermittent access intake day 1-15 change2.24.65.3-2.3-2.2-2.2-2.2-2.3-2.3-2.2-2.2-2.22.2-2.10.6
Intermittent access intake escalation2.75.56.3-2.5-2.4-2.4-2.4-2.5-2.5-2.5-2.4-2.42.5-2.41.0
Intermittent access intake escalation 26.57.48.5-2.9-2.9-2.9-2.9-2.9-2.9-2.8-2.8-2.82.8-2.60.8
Intermitt. access day 1 inactive lever presses0.52.03.31.81.51.41.41.51.41.31.51.4-1.41.20.9
Intermitt. access day 15 inactive lever presses0.30.63.60.70.30.10.10.70.70.60.50.7-0.70.11.9
Intermitt. access escalation Index0.50.71.71.00.80.80.80.91.00.80.80.8-0.80.21.3
Intermittent access day 1 total infusions2.03.24.5-2.1-2.1-2.1-2.1-1.8-1.8-1.8-1.8-1.71.6-1.6-0.5
Intermittent access day 15 total infusions7.210.713.8-3.7-3.5-3.5-3.5-3.4-3.4-3.3-3.3-3.33.2-3.30.4
Intermittent access terminal intake (last 3 days)8.411.114.7-3.8-3.8-3.8-3.8-3.5-3.5-3.2-3.2-3.13.2-3.30.5
Intermittent access total infusions5.76.88.9-3.0-2.9-2.9-2.9-2.8-2.7-2.6-2.5-2.52.5-2.40.2
Intermittent access day 1 locomotion0.81.02.1-1.2-1.2-1.4-1.4-0.9-0.8-0.9-0.9-0.80.6-1.1-0.2
Intermittent access day 15 total locomotion0.61.11.9-1.1-1.3-1.4-1.4-1.1-1.1-1.2-0.9-0.90.9-0.7-0.5
Intermittent access total locomotion2.02.44.2-1.7-1.9-2.0-2.0-1.5-1.5-1.6-1.4-1.31.3-1.3-0.0
Intermittent access standard deviation3.57.28.5-2.7-2.8-2.6-2.6-2.9-2.9-2.8-2.8-2.82.9-2.81.4
Left kidney weight0.10.21.0-0.2-0.4-0.5-0.5-0.2-0.3-0.2-0.3-0.50.5-0.71.0
Right kidney weight0.10.30.60.60.60.40.40.80.80.70.60.5-0.60.30.4
Cocaine induced anxiety0.30.40.50.60.50.60.60.60.60.70.70.7-0.70.40.5
Post-drug Anxiety2.02.13.31.51.71.81.81.41.41.41.41.4-1.31.4-0.5
Baseline Anxiety0.40.41.20.60.70.80.80.50.60.50.50.4-0.20.8-1.1
Tail length0.62.23.41.51.61.31.31.61.51.81.51.3-1.51.4-1.3
Length with tail0.41.82.71.31.51.51.51.31.31.61.21.0-1.01.3-1.6
Length without tail0.00.20.6-0.2-0.10.20.2-0.3-0.4-0.3-0.4-0.40.6-0.2-0.8
Times rat made contact with spout0.10.10.2-0.4-0.4-0.4-0.4-0.3-0.3-0.2-0.2-0.20.2-0.30.2
Lifetime Intake4.85.97.5-2.7-2.7-2.7-2.7-2.6-2.5-2.5-2.4-2.32.3-2.30.7
Liver weight, left0.50.81.20.80.90.80.80.90.90.90.90.9-0.90.9-1.1
Liver weight, right0.20.31.90.50.20.40.40.40.40.50.20.4-0.40.11.4
Locomotor activity0.00.00.00.20.10.20.20.10.00.0-0.0-0.0-0.10.1-0.0
Locomotor testing distance0.00.00.20.10.20.30.30.20.10.20.10.2-0.20.2-0.4
Locomotor testing rearing0.61.21.7-1.1-1.3-1.3-1.3-1.1-1.1-0.9-1.2-1.01.0-1.00.5
Locomotion in novel chamber0.91.22.21.00.81.01.00.91.10.91.11.3-1.21.5-1.0
Locomotion in novel chamber post-restriction0.00.00.30.40.00.00.00.10.20.10.10.1-0.10.00.6
Fecal boli incidents, locomotor time 10.20.20.40.50.50.40.40.60.60.60.40.5-0.60.4-0.0
Change in fecal boli incidents, locomotor task2.92.93.6-1.8-1.8-1.6-1.6-1.9-1.8-1.8-1.7-1.91.9-1.50.5
Time >=10cm from walls, locomotor time 11.01.11.5-1.1-1.2-1.2-1.2-1.1-1.1-1.2-1.1-1.01.0-0.6-0.2
Bouts of movement, locomotor time 10.60.76.70.1-0.3-0.2-0.2-0.4-0.4-0.3-0.4-0.40.5-0.42.6
Total resting periods, locomotor time 10.50.54.50.0-0.4-0.2-0.2-0.5-0.5-0.4-0.5-0.50.6-0.42.1
Rest time, locomotor task time 10.10.20.90.2-0.2-0.1-0.1-0.4-0.4-0.4-0.4-0.50.4-0.31.0
Distance moved, locomotor task time 10.00.00.1-0.10.20.20.20.20.20.30.30.3-0.20.2-0.2
Vertical activity count, locomotor time 10.10.22.0-0.20.30.40.40.20.20.10.30.3-0.20.3-1.4
Time >=10cm from walls, locomotor time 20.30.51.0-0.6-0.7-0.9-0.9-0.6-0.6-0.6-0.7-0.50.7-0.2-1.0
Bouts of movement, locomotor time 20.30.53.90.70.50.50.50.50.50.50.30.4-0.30.22.0
Total resting periods, locomotor time 20.30.64.50.70.40.50.50.40.50.50.30.4-0.30.22.1
Rest time, locomotor task time 20.10.20.90.30.20.40.40.20.30.30.30.3-0.30.21.0
Distance moved, locomotor task time 20.00.00.1-0.0-0.2-0.1-0.1-0.1-0.10.1-0.10.10.1-0.10.2
Vertical activity count, locomotor time 21.01.41.91.21.11.11.11.21.21.21.21.2-1.11.4-1.0
Light reinforcement 10.71.62.51.51.01.11.11.31.31.41.41.4-1.61.20.8
Light reinforcement 22.33.54.42.01.81.91.92.02.01.92.02.1-2.11.7-0.1
Bone: marrow area0.30.74.3-0.9-0.5-0.7-0.7-0.7-0.7-0.6-0.7-0.50.6-0.3-2.1
Bone: maximum diameter0.00.10.2-0.3-0.5-0.5-0.5-0.2-0.3-0.0-0.10.2-0.10.0-0.3
Bone: maximum force0.30.43.20.20.10.10.10.30.30.50.50.7-0.50.8-1.8
Bone: maximum moment0.20.32.8-0.3-0.2-0.3-0.3-0.1-0.10.10.00.2-0.10.3-1.7
Mean time between licks in bursts0.41.02.90.81.11.01.00.90.80.80.90.8-0.71.1-1.7
Mean num. licks in bursts0.10.20.30.50.40.30.30.50.60.60.40.4-0.50.30.2
Cd content in liver0.40.50.90.80.40.50.50.60.60.60.90.7-0.70.61.0
Co content in liver0.20.32.80.30.20.30.30.10.10.10.10.1-0.3-0.21.7
Cu content in liver3.23.84.3-2.0-2.1-2.1-2.1-2.0-2.0-2.0-2.0-2.01.9-2.01.2
Fe content in liver0.50.60.7-0.8-0.8-0.8-0.8-0.7-0.7-0.8-0.8-0.80.8-0.6-0.6
K content in liver0.70.71.0-0.8-0.6-0.7-0.7-0.8-0.8-0.8-1.0-1.00.9-1.00.8
Mg content in liver0.60.60.9-0.8-0.6-0.6-0.6-0.8-0.8-0.8-1.0-0.90.8-0.90.4
Mn content in liver0.00.10.10.20.40.30.30.20.20.2-0.1-0.1-0.1-0.10.2
Na content in liver1.21.31.6-1.2-1.1-1.3-1.3-1.0-1.0-1.0-1.2-1.21.2-1.30.6
Rb content in liver0.10.10.3-0.2-0.3-0.1-0.1-0.3-0.3-0.2-0.2-0.1-0.1-0.20.6
Se content in liver0.00.10.4-0.00.1-0.1-0.10.00.0-0.0-0.3-0.2-0.0-0.30.6
Sr content in liver0.30.20.70.30.80.60.60.50.60.2-0.1-0.20.10.2-0.8
Zn content in liver3.13.44.0-1.9-1.9-1.8-1.8-1.8-1.8-1.9-1.9-1.91.9-2.01.3
Bone: minimum diameter0.91.612.10.40.70.50.50.70.70.90.81.0-0.91.3-3.5
Time in familiar zone, hab. session 10.70.71.9-0.6-0.6-0.5-0.5-0.8-0.8-0.8-0.9-0.80.8-1.01.4
Time in novel zone, hab. session 10.10.10.20.1-0.1-0.2-0.20.30.30.30.40.3-0.40.3-0.3
Total zone transitions, hab. session 11.31.72.21.31.41.51.51.31.31.21.31.2-1.21.5-1.1
Total locomotion distance, hab. session 10.50.62.60.50.70.80.80.60.60.60.60.6-0.60.8-1.6
Locomotion velocity, hab. session 10.91.33.30.91.11.11.11.01.01.01.01.0-1.01.3-1.8
Time in familiar zone, hab. session 21.92.05.0-1.1-1.3-1.1-1.1-1.4-1.4-1.4-1.3-1.31.3-1.62.2
Time in novel zone, hab. session 20.60.62.80.50.50.30.30.80.80.80.70.7-0.70.9-1.7
Total zone transitions, hab. session 20.40.60.91.00.91.01.00.70.70.70.60.6-0.70.70.5
Total locomotion distance, hab. session 20.20.30.50.60.50.50.50.50.50.50.60.5-0.60.7-0.6
Locomotion velocity, hab. session 20.10.20.30.40.40.40.40.40.30.40.40.4-0.50.6-0.5
Novel to familiar place preference ratio0.00.00.3-0.00.1-0.1-0.10.20.20.20.10.1-0.10.1-0.5
Novelty place preference0.00.00.1-0.2-0.1-0.3-0.30.00.00.1-0.1-0.00.0-0.1-0.2
Time in novel zone, NPP test0.00.00.1-0.0-0.0-0.3-0.30.10.10.20.00.1-0.1-0.10.1
Total zone transitions, NPP test1.01.52.41.41.51.51.51.21.21.11.01.0-1.01.2-0.0
Total locomotion distance, NPP test0.50.70.90.80.90.90.90.70.70.80.80.8-0.80.9-1.0
Locomotion velocity, NPP test0.20.31.20.40.50.60.60.40.40.50.50.5-0.50.7-1.1
Intraocular pressure2.33.34.31.91.91.91.91.81.81.81.71.7-1.72.1-1.4
Delta distance traveled before/after self-admin3.43.65.2-2.1-2.0-2.3-2.3-1.8-1.9-1.8-1.9-1.82.0-1.90.0
Delta ambulatory time before/after self-admin3.13.85.6-2.1-2.1-2.4-2.4-1.9-1.9-1.9-2.0-1.92.0-1.90.1
Parametrial fat weight0.10.10.30.30.40.50.50.30.30.20.20.3-0.30.5-0.5
Pavlov. Cond. lever latency0.60.71.0-0.8-0.9-0.9-0.9-0.8-0.8-0.8-0.8-0.80.9-1.01.0
Pavlov. Cond. magazine entry latency0.30.40.60.60.60.70.70.50.50.60.60.6-0.70.8-0.8
Pavlov. Cond. change in total contacts2.83.03.71.81.81.81.81.71.71.71.71.7-1.81.9-1.3
Pavlov. Cond. index score0.91.11.31.11.11.11.11.01.01.01.01.0-1.11.2-0.6
Pavlov. Cond. latency score0.81.01.21.01.01.11.10.90.91.01.01.0-1.11.1-0.5
Pavlov. Cond. lever contacts0.80.91.90.81.01.01.00.90.90.80.80.8-0.91.1-1.4
Pavlov. Cond. magazine entry number0.91.21.4-1.2-1.1-1.2-1.2-1.0-1.0-1.1-1.1-1.11.2-1.20.5
Pavlov. Cond. intertrial magazine entries0.50.60.8-0.8-0.7-0.7-0.7-0.8-0.8-0.8-0.9-0.90.8-0.7-0.2
Pavlov. Cond. lever-magazine prob. diff.0.81.01.21.01.01.01.00.90.91.01.01.0-1.11.1-0.6
Pavlov. Cond. response bias0.91.11.51.01.11.11.11.01.01.01.01.0-1.11.2-1.2
Pavlov. Cond. lever latency1.31.72.41.51.41.31.31.51.51.41.31.1-1.41.40.0
Pavlov. Cond. magazine entry latency0.00.00.1-0.1-0.2-0.1-0.1-0.2-0.20.00.10.2-0.00.1-0.3
Pavlov. Cond. change in total contacts0.20.33.4-0.5-0.2-0.2-0.2-0.3-0.2-0.2-0.2-0.00.30.1-1.8
Pavlov. Cond. index score0.20.31.3-0.7-0.5-0.4-0.4-0.6-0.6-0.4-0.3-0.10.4-0.2-1.2
Pavlov. Cond. latency score0.30.50.9-0.9-0.7-0.6-0.6-0.8-0.8-0.6-0.5-0.40.6-0.5-0.9
Pavlov. Cond. lever contacts0.71.01.5-1.2-1.0-0.9-0.9-1.2-1.2-1.1-1.1-0.81.1-1.0-0.3
Pavlov. Cond. magazine entry number0.00.10.50.0-0.0-0.1-0.1-0.0-0.0-0.1-0.2-0.30.1-0.20.7
Pavlov. Cond. intertrial magazine entries0.20.40.70.50.70.70.70.60.60.50.40.4-0.50.6-0.8
Pavlov. Cond. lever-magazine prob. diff.0.20.31.1-0.7-0.5-0.4-0.4-0.6-0.6-0.5-0.4-0.20.5-0.3-1.0
Pavlov. Cond. response bias0.30.40.9-0.8-0.6-0.6-0.6-0.7-0.7-0.6-0.5-0.30.6-0.5-1.0
Time in closed arm before self-admin0.91.22.4-1.1-1.1-1.2-1.2-0.9-1.0-1.0-1.0-1.00.9-1.60.8
Time in closed arm after self-admin0.40.42.1-0.1-0.5-0.5-0.5-0.6-0.6-0.6-0.5-0.60.5-0.71.4
Time in open arm before self-admin0.10.11.1-0.10.00.10.1-0.00.10.10.10.1-0.20.4-1.0
Time in open arm after self-admin0.50.51.10.30.80.70.70.80.80.80.60.7-1.00.5-0.7
Bone: periosteal estimation0.30.67.0-0.2-0.1-0.2-0.2-0.0-0.00.20.10.4-0.30.6-2.6
Bone: periosteal perimeter0.10.20.8-0.5-0.6-0.6-0.6-0.4-0.4-0.3-0.4-0.10.2-0.2-0.9
Bone: post-yield work3.45.06.2-2.4-2.5-2.5-2.5-2.4-2.4-2.1-2.3-2.22.2-2.20.6
Progressive ratio test 1 active lever presses1.92.43.5-1.6-1.8-1.9-1.9-1.5-1.5-1.5-1.5-1.41.5-1.50.7
Progressive ratio test 1 breakpoint2.02.43.6-1.6-1.8-1.9-1.9-1.6-1.5-1.5-1.5-1.51.5-1.50.7
Progressive ratio test 1 inactive lever presses0.00.00.1-0.1-0.1-0.3-0.3-0.0-0.1-0.0-0.0-0.0-0.10.1-0.2
Progressive ratio test 2 active lever presses4.95.77.4-2.7-2.5-2.4-2.4-2.6-2.5-2.6-2.5-2.52.4-2.1-0.4
Progressive ratio test 2 breakpoint4.75.47.1-2.7-2.5-2.4-2.4-2.5-2.4-2.6-2.4-2.42.4-2.0-0.4
Progressive ratio test 2 inactive lever presses1.01.62.5-1.6-1.5-1.5-1.5-1.3-1.2-1.3-1.2-1.21.0-1.30.2
Incentive Sensitization - Responses2.02.84.2-2.1-1.7-1.5-1.5-1.9-1.8-1.9-1.7-1.81.6-1.1-1.4
Incentive Sensitization - Breakpoint2.32.94.4-2.1-1.7-1.5-1.5-1.9-1.8-2.0-1.8-1.81.6-1.2-1.3
Sum of active levers in priming session hrs 5-60.70.61.0-1.0-0.8-0.5-0.5-1.0-0.9-1.0-0.6-0.80.8-0.6-0.8
Progressive ratio0.71.13.9-0.5-1.1-1.1-1.1-1.0-0.9-0.8-0.8-1.11.1-0.92.0
Food seeking constrained by brief footshock3.64.45.32.02.22.32.32.02.02.01.92.2-2.02.2-2.0
Seeking ratio, punishment vs. effort2.84.06.71.52.22.22.21.91.81.71.72.0-1.91.9-2.6
Retroperitoneal fat weight0.20.81.31.01.01.11.10.80.70.90.90.8-0.81.0-0.5
Reaction time number correct0.30.51.7-0.7-0.6-0.7-0.7-0.7-0.7-0.7-0.7-0.60.5-0.4-1.3
Reaction time mean minus median1.53.65.12.21.71.81.82.02.01.82.02.3-2.01.90.9
Reaction time mean minus median AUC1.84.66.72.41.92.02.02.32.32.12.42.6-2.32.30.4
Reaction time num false alarms1.11.62.1-1.5-1.2-1.4-1.4-1.3-1.2-1.2-1.2-1.21.1-0.9-1.3
Reaction time num false alarms AUC1.11.72.3-1.5-1.3-1.5-1.5-1.3-1.3-1.3-1.2-1.21.1-1.0-1.1
Reaction time trials correct on left0.30.51.7-0.7-0.6-0.7-0.7-0.7-0.7-0.7-0.7-0.60.5-0.4-1.3
Reaction time trials on left0.20.41.8-0.6-0.5-0.6-0.6-0.6-0.6-0.6-0.6-0.50.4-0.3-1.3
Reaction time mean1.82.94.61.71.51.71.71.61.71.51.92.1-1.91.9-0.4
Reaction time mean AUC1.93.15.01.71.61.61.61.71.81.62.02.2-2.02.0-0.6
Median of all reaction times1.52.13.31.31.31.41.41.31.31.31.61.8-1.61.7-1.0
Reaction time omissions4.66.78.22.82.52.52.52.82.82.92.82.9-2.82.6-0.3
Reaction time false alarm rate0.30.40.6-0.8-0.7-0.8-0.8-0.7-0.6-0.6-0.6-0.60.6-0.60.1
Reaction time premature initiation rate1.62.22.9-1.3-1.5-1.4-1.4-1.4-1.3-1.5-1.4-1.61.6-1.51.7
Reaction time premature initiations1.32.32.7-1.5-1.6-1.5-1.5-1.5-1.4-1.6-1.6-1.61.6-1.51.0
Std. dev. reaction times1.32.33.91.71.21.41.41.61.61.51.72.0-1.71.50.7
Reaction time trials completed0.20.41.8-0.6-0.5-0.6-0.6-0.6-0.6-0.6-0.6-0.50.4-0.3-1.3
Reaction time trials AUC0.20.32.0-0.5-0.4-0.5-0.5-0.5-0.5-0.5-0.5-0.40.3-0.2-1.4
Run reversals in cocaine runway, females0.40.40.80.60.70.90.90.60.60.50.80.6-0.50.6-0.3
Run reversals in cocaine runway, males2.62.63.01.51.61.71.71.71.71.71.71.7-1.71.7-1.0
Latency to leave start box in cocaine runway0.91.01.3-1.0-1.0-1.1-1.1-1.0-1.0-1.1-1.1-1.01.1-1.10.3
Latency to leave start box in cocaine runway, F3.43.94.7-2.0-2.0-2.0-2.0-2.1-2.1-2.2-2.1-2.12.1-2.00.5
Latency to leave start box in cocaine runway, M2.62.53.21.81.61.61.61.61.61.61.61.7-1.61.6-0.4
Std. dev. time between licks in bursts0.10.10.8-0.10.10.20.20.0-0.0-0.1-0.10.00.10.2-0.9
Total sessions with >9 infusions2.22.63.6-1.8-1.8-1.9-1.9-1.6-1.6-1.7-1.5-1.41.3-1.61.1
Short access day 1 total inactive lever presses1.21.63.2-1.0-1.3-1.2-1.2-1.1-1.2-1.3-1.1-1.21.2-1.31.8
Short access day 10 total inactive lever presses0.10.40.90.90.80.80.80.40.30.20.30.2-0.20.41.0
Short access day 1 total infusions2.33.03.7-1.7-1.9-1.6-1.6-1.9-1.9-1.8-1.7-1.71.6-1.61.5
Short access day 10 total infusions2.73.54.9-2.2-2.0-2.2-2.2-1.8-1.8-1.8-1.9-1.81.7-1.90.6
Short access total infusions2.12.73.8-1.8-1.9-2.0-2.0-1.6-1.6-1.6-1.5-1.51.5-1.60.9
Short access day 1 locomotion0.30.40.6-0.6-0.8-0.8-0.8-0.5-0.5-0.5-0.4-0.30.3-0.60.8
Short access day 10 total locomotion0.20.30.50.50.50.40.40.70.70.60.70.7-0.70.50.3
Short access total locomotion0.50.61.3-0.8-1.0-1.2-1.2-0.7-0.6-0.7-0.6-0.50.5-0.70.3
One hour access (0.3 mA shock)5.66.57.9-2.8-2.6-2.6-2.6-2.7-2.7-2.7-2.8-2.72.6-2.3-0.4
Compulsive drug intake0.70.81.61.01.31.21.20.91.00.70.60.6-0.60.60.0
One hour access (shock baseline)6.810.413.3-3.6-3.6-3.6-3.6-3.4-3.4-3.2-3.2-3.23.1-3.0-0.4
Social response proportion0.30.40.70.70.50.40.40.80.80.60.50.7-0.80.30.4
Social responses0.70.91.41.10.80.80.81.01.11.01.01.1-1.20.70.7
Social time0.10.10.2-0.1-0.3-0.5-0.50.20.10.20.30.4-0.50.1-0.3
Soleus weight1.02.93.81.71.71.61.61.81.81.91.81.8-2.01.7-0.9
Bone: stiffness0.20.30.70.40.20.20.20.40.40.60.50.7-0.60.6-0.8
Tibialis anterior weight9.431.737.35.86.15.85.85.95.95.85.65.5-5.75.8-3.3
Time to tail flick, vehicle, before self-admin0.40.40.7-0.5-0.5-0.2-0.2-0.8-0.8-0.8-0.7-0.80.7-0.4-0.7
Time to tail flick, vehicle, after self-admin2.63.44.5-2.1-1.7-1.7-1.7-1.9-2.0-2.1-2.0-2.02.1-1.90.2
Time to tail flick, test, before self-admin0.10.10.80.10.00.10.1-0.00.00.2-0.1-0.1-0.3-0.30.9
Time to tail flick, test, after self-admin1.61.62.7-1.3-1.5-1.6-1.6-1.2-1.2-1.0-1.1-1.21.1-1.40.6
Delta time to tail flick, vehicle, before/after SA3.02.83.5-1.9-1.7-1.9-1.9-1.6-1.7-1.8-1.7-1.61.9-1.60.5
Delta time to tail flick, test, before/after SA0.00.00.1-0.1-0.2-0.3-0.30.10.1-0.10.20.20.1-0.00.2
Tibia length1.23.44.3-1.9-1.8-1.8-1.8-2.0-2.0-1.8-2.1-1.91.9-2.11.0
Ambulatory time before self-admin0.91.42.21.21.31.51.51.21.01.11.11.1-1.21.2-0.1
Ambulatory time after self-admin0.30.40.7-0.8-0.6-0.8-0.8-0.4-0.6-0.6-0.7-0.60.6-0.6-0.2
Bone: tissue strength3.23.34.8-1.8-1.9-2.2-2.2-1.7-1.6-1.8-1.8-1.92.0-1.70.8
Total heroin consumption0.10.10.9-0.5-0.2-0.3-0.3-0.2-0.1-0.1-0.2-0.20.1-0.1-1.0
Bone: trabecular number0.50.91.3-1.1-1.0-0.8-0.8-1.1-1.1-0.9-0.9-1.00.9-0.9-0.1
Bone: trabecular spacing1.01.31.81.31.21.11.11.31.31.21.21.2-1.21.10.5
Bone: trabecular thickness1.62.02.8-1.7-1.6-1.5-1.5-1.6-1.6-1.4-1.1-1.21.3-1.0-1.0
Bone: trabecular tissue density2.73.95.42.21.71.81.82.12.12.12.32.3-2.22.10.5
Water consumed over 24 hours0.10.10.20.40.30.30.30.30.30.30.50.5-0.40.4-0.0
Number of responses in last shaping day0.70.81.2-0.9-1.1-1.0-1.0-0.9-0.8-0.9-0.7-0.80.9-0.80.5