Hub : Genes

Tbx10

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver mRNA stability Tbx10 0.04 0.03 2.7e-03 0.01 0.01 0.01 0.01 2.9e-02 6.8e-03 2.9e-02 1.5e-02
2 Liver gene expression Tbx10 0.24 0.12 0.0e+00 0.16 0.18 0.16 0.16 6.6e-17 2.0e-19 9.4e-18 1.2e-17
3 Adipose gene expression Tbx10 0.04 0.03 6.2e-03 0.01 0.01 0.01 0.01 4.0e-02 3.2e-02 2.0e-02 2.7e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bone: apparent density1.32.53.80.71.8-2.0
Area under the delay curve0.50.81.20.71.1-0.9
BMI with tail1.34.612.2-0.31.3-3.5
BMI without tail0.42.35.8-1.10.0-2.4
Body weight1.35.79.2-2.6-1.0-3.0
Weight adjusted by age0.30.81.4-1.2-0.9-0.5
Bone surface1.63.17.9-0.41.0-2.8
Bone volume1.01.93.70.41.4-1.9
Breakpoint value in progressive ratio session0.81.41.8-1.3-0.7-1.4
Number of licking bursts0.00.00.10.10.3-0.2
Context. condit. distance diff. score0.70.81.41.20.90.5
Locomotion velocity, session 10.00.00.00.00.10.0
Locomotion distance, session 10.81.02.00.31.0-1.4
Locomotion velocity, session 21.11.42.2-1.5-0.9-1.1
Locomotion distance, session 20.50.61.6-0.50.1-1.3
Locomotion velocity, session 31.11.31.90.91.4-1.1
Locomotion distance, session 30.10.10.10.20.4-0.3
Stereotopy head waving bouts, day 31.21.42.21.21.5-0.7
Stereotopy head waving duration, day 31.11.42.11.41.4-0.0
Locomotion velocity, session 70.70.81.00.61.0-0.9
Locomotion distance, session 70.20.20.6-0.30.0-0.8
Stereotopy head waving bouts, day 71.21.42.21.21.5-0.8
Stereotopy head waving duration, day 70.81.02.00.31.0-1.4
Locomotion velocity, session 80.70.81.3-1.1-0.6-0.8
Locomotion distance, session 80.30.50.70.80.8-0.1
Degree of sensitization distance0.30.30.8-0.20.2-0.9
Degree of sensitization stereotypy0.40.40.70.20.6-0.9
Conditioned locomotion2.93.45.3-2.3-2.20.2
Cocaine response after cond. corrected0.10.10.20.40.4-0.1
Cocaine response after cond. not corrected0.20.30.50.60.7-0.4
Cocaine response before conditioning0.10.10.10.10.3-0.4
Saline control response1.31.82.9-1.7-0.9-1.4
Bone: connectivity density1.82.87.0-0.21.2-2.6
Bone: cortical apparent density0.40.60.9-1.0-1.00.1
Bone: cortical area0.60.91.5-1.2-1.20.1
Bone: cortical porosity0.10.10.20.00.1-0.4
Bone: cortical porosity0.20.20.2-0.5-0.2-0.5
Bone: cortical thickness4.57.512.2-3.5-3.2-0.2
Bone: cortical thickness1.51.83.1-1.8-1.5-0.2
Bone: cortical tissue density0.50.81.3-1.1-1.1-0.0
Condit. Reinf. active minus inactive responses0.20.30.50.20.5-0.7
Condit. Reinf. active-inactive response ratio0.20.20.30.40.6-0.4
Condit. Reinf. active responses0.00.00.00.10.2-0.2
Condit. Reinf. inactive responses0.00.00.10.1-0.10.3
Incentive salience index mean0.10.20.40.00.3-0.6
Condit. Reinf. lever presses0.00.00.1-0.2-0.20.1
Condit. Reinf. active minus inactive responses1.01.52.41.41.5-0.6
Condit. Reinf. active-inactive response ratio1.11.83.11.81.50.2
Condit. Reinf. active responses1.11.62.21.01.5-1.2
Condit. Reinf. inactive responses0.50.72.0-0.30.4-1.4
Condit. Reinf. lever presses0.50.82.0-0.00.7-1.4
Condit. Reinf. lever reinforcers received1.11.52.00.81.4-1.4
Conditioned reinforcement - actives0.10.40.8-0.2-0.70.9
Conditioned reinforcement - inactives0.82.23.92.01.40.9
Conditioned locomotion3.34.96.92.61.22.5
Patch foraging indifference point 0 sec0.10.30.50.70.50.1
Patch foraging indifference point AUC0.51.21.9-1.4-1.3-0.1
Delay disc. indifference point, 0s delay1.51.72.41.11.6-1.2
Delay disc. indifference point, 16s delay0.60.91.61.31.00.3
Delay disc. indifference point, 2s delay0.80.91.41.11.2-0.3
Delay disc. indifference point, 24s delay0.20.30.4-0.5-0.60.4
Delay disc. indifference point, 4s delay0.40.50.80.30.7-0.9
Delay disc. indifference point, 8s delay0.20.30.40.30.6-0.6
Indifference point function ln k0.92.84.32.11.11.7
Indifference point function log k0.92.84.32.11.11.7
Patch foraging total patch changes 0 sec0.00.00.10.1-0.10.3
Patch foraging total patch changes 12 sec1.31.72.6-1.6-1.0-1.2
Patch foraging total patch changes 18 sec0.10.20.3-0.3-0.0-0.6
Patch foraging total patch changes 24 sec0.20.81.4-1.2-1.0-0.2
Patch foraging total patch changes 6 sec0.40.71.9-0.50.1-1.4
Patch foraging time to switch 0 sec0.51.94.30.11.2-2.1
Patch foraging water rate 0 sec0.93.69.40.7-0.93.1
Patch foraging water rate 12 sec1.24.812.41.2-0.63.5
Patch foraging water rate 18 sec0.40.92.20.70.01.5
Patch foraging water rate 24 sec1.42.04.90.3-0.92.2
Patch foraging water rate 6 sec1.42.15.20.0-1.02.3
Seeking ratio, delayed vs. immediate footshock0.50.81.00.61.0-0.9
Distance traveled before self-admin0.10.20.40.30.6-0.4
Distance traveled after self-admin0.00.00.00.00.10.1
Extensor digitorum longus weight4.216.728.2-5.3-3.7-2.8
Bone: elastic displacement1.72.13.4-1.1-1.81.3
Bone: elastic work2.12.84.5-2.1-2.0-0.1
Bone: endosteal estimation1.43.55.52.32.2-0.1
Bone: endosteal perimeter2.97.011.23.33.1-0.1
Epididymis fat weight1.57.411.53.42.02.6
Delta time in closed arm before/after self-admin1.21.11.8-1.3-1.1-0.6
Delta time in open arm before/after self-admin0.20.30.40.50.6-0.4
Diff in mean of infusions in LGA sessions0.30.50.9-1.0-0.7-0.3
Delay discount exponential model param0.40.60.8-0.5-0.90.8
Extinction: sum of active levers before priming0.50.81.7-0.8-0.0-1.3
Active lever presses in extinction session 61.01.01.7-1.3-1.1-0.5
Bone: final force0.50.81.1-1.0-0.4-1.1
Bone: final moment0.50.81.1-1.0-0.4-1.0
Food consumed during 24 hour testing period0.10.30.70.2-0.20.8
Glucose2.94.66.92.62.6-0.2
Heart weight1.42.23.61.51.9-0.9
Delay discount hyperbolic model param0.50.70.9-0.6-1.00.8
Intermittent access intake day 1-15 change0.42.33.41.70.81.8
Intermittent access intake escalation0.42.03.21.50.71.8
Intermittent access intake escalation 20.91.52.11.40.71.4
Intermitt. access day 1 inactive lever presses0.00.00.00.1-0.0-0.0
Intermitt. access day 15 inactive lever presses0.42.13.41.81.70.2
Intermitt. access escalation Index0.41.32.71.10.11.6
Intermittent access day 1 total infusions1.64.87.32.52.7-1.0
Intermittent access day 15 total infusions2.25.39.33.12.31.1
Intermittent access terminal intake (last 3 days)3.05.39.13.02.60.3
Intermittent access total infusions3.23.76.12.52.3-0.2
Intermittent access day 1 locomotion1.22.13.01.71.7-0.8
Intermittent access day 15 total locomotion1.34.98.72.92.30.9
Intermittent access total locomotion5.97.012.43.52.90.6
Intermittent access standard deviation0.20.91.51.21.00.5
Left kidney weight0.32.74.42.11.41.3
Right kidney weight0.21.52.61.30.51.6
Cocaine induced anxiety0.00.10.20.30.40.1
Post-drug Anxiety0.10.10.2-0.4-0.1-0.3
Baseline Anxiety0.30.40.8-0.9-0.7-0.3
Tail length0.73.55.6-2.4-2.2-0.1
Length with tail1.77.312.8-3.6-2.9-1.0
Length without tail0.94.68.1-2.8-2.1-1.0
Times rat made contact with spout0.30.41.0-0.20.4-1.0
Lifetime Intake1.82.23.51.91.7-0.3
Liver weight, left0.30.61.50.2-0.41.2
Liver weight, right0.51.02.20.80.11.5
Locomotor activity0.40.61.60.5-0.11.3
Locomotor testing distance0.30.82.00.6-0.11.4
Locomotor testing rearing0.30.91.61.31.00.5
Locomotion in novel chamber3.85.18.42.92.11.5
Locomotion in novel chamber post-restriction0.82.54.42.11.31.2
Fecal boli incidents, locomotor time 10.00.00.10.20.1-0.2
Change in fecal boli incidents, locomotor task0.00.00.1-0.10.1-0.2
Time >=10cm from walls, locomotor time 12.42.94.42.02.1-0.5
Bouts of movement, locomotor time 11.01.42.0-1.4-1.40.1
Total resting periods, locomotor time 10.70.81.3-1.0-1.20.4
Rest time, locomotor task time 10.71.12.80.80.01.7
Distance moved, locomotor task time 10.30.81.20.51.0-1.1
Vertical activity count, locomotor time 10.21.11.71.31.30.0
Time >=10cm from walls, locomotor time 20.00.10.20.1-0.20.4
Bouts of movement, locomotor time 20.10.40.6-0.8-0.6-0.6
Total resting periods, locomotor time 20.00.20.4-0.3-0.2-0.6
Rest time, locomotor task time 21.22.13.61.91.60.3
Distance moved, locomotor task time 20.91.31.9-1.4-1.30.2
Vertical activity count, locomotor time 20.92.13.2-1.3-1.81.2
Light reinforcement 10.10.51.10.60.11.1
Light reinforcement 20.61.42.61.20.41.6
Bone: marrow area1.53.65.72.42.3-0.1
Bone: maximum diameter0.00.10.20.30.00.5
Bone: maximum force0.91.84.7-0.30.8-2.2
Bone: maximum moment0.81.64.2-0.40.6-2.1
Mean time between licks in bursts0.10.40.7-0.8-0.5-0.5
Mean num. licks in bursts0.00.10.20.10.1-0.4
Cd content in liver1.11.22.01.41.00.8
Co content in liver1.11.32.2-0.5-1.21.5
Cu content in liver0.00.00.00.1-0.00.2
Fe content in liver0.10.10.2-0.4-0.3-0.2
K content in liver0.30.20.7-0.20.2-0.8
Mg content in liver0.50.50.80.90.9-0.0
Mn content in liver1.11.21.9-1.4-0.8-1.1
Na content in liver0.50.50.7-0.5-0.80.8
Rb content in liver1.41.72.51.61.6-0.1
Se content in liver0.50.60.90.90.9-0.2
Sr content in liver2.01.82.9-1.7-1.6-0.1
Zn content in liver0.40.50.8-0.9-0.90.1
Bone: minimum diameter1.73.35.02.12.2-0.7
Time in familiar zone, hab. session 10.40.50.80.90.80.0
Time in novel zone, hab. session 10.10.10.1-0.3-0.30.1
Total zone transitions, hab. session 10.20.20.4-0.5-0.1-0.7
Total locomotion distance, hab. session 10.30.50.80.90.80.3
Locomotion velocity, hab. session 10.10.10.20.40.40.1
Time in familiar zone, hab. session 20.70.81.3-1.1-1.10.2
Time in novel zone, hab. session 20.80.91.40.91.2-0.8
Total zone transitions, hab. session 22.12.65.60.31.5-2.4
Total locomotion distance, hab. session 21.01.31.80.91.3-1.1
Locomotion velocity, hab. session 21.01.42.11.11.5-0.9
Novel to familiar place preference ratio0.20.30.40.20.6-0.6
Novelty place preference0.30.40.60.50.8-0.5
Time in novel zone, NPP test0.30.40.70.50.8-0.5
Total zone transitions, NPP test0.50.82.1-0.30.4-1.5
Total locomotion distance, NPP test0.30.30.60.50.7-0.5
Locomotion velocity, NPP test0.10.20.30.40.6-0.3
Intraocular pressure0.40.61.3-0.1-0.81.2
Delta distance traveled before/after self-admin0.20.20.3-0.4-0.50.4
Delta ambulatory time before/after self-admin0.20.30.4-0.6-0.70.4
Parametrial fat weight2.04.78.22.92.21.0
Pavlov. Cond. lever latency0.10.10.20.40.10.4
Pavlov. Cond. magazine entry latency0.70.81.40.91.2-0.6
Pavlov. Cond. change in total contacts0.60.60.91.00.9-0.1
Pavlov. Cond. index score0.00.10.10.30.30.2
Pavlov. Cond. latency score0.10.10.20.30.4-0.1
Pavlov. Cond. lever contacts0.00.00.0-0.00.1-0.2
Pavlov. Cond. magazine entry number0.00.10.1-0.3-0.2-0.3
Pavlov. Cond. intertrial magazine entries0.30.40.7-0.2-0.60.8
Pavlov. Cond. lever-magazine prob. diff.0.00.00.10.30.30.1
Pavlov. Cond. response bias0.00.00.10.20.10.3
Pavlov. Cond. lever latency0.00.00.00.10.1-0.1
Pavlov. Cond. magazine entry latency1.31.94.8-0.90.2-2.2
Pavlov. Cond. change in total contacts0.20.61.00.30.8-1.0
Pavlov. Cond. index score0.30.51.4-0.30.3-1.2
Pavlov. Cond. latency score0.20.41.0-0.30.3-1.0
Pavlov. Cond. lever contacts0.00.00.0-0.10.0-0.0
Pavlov. Cond. magazine entry number1.82.35.71.1-0.12.4
Pavlov. Cond. intertrial magazine entries0.40.91.71.00.31.3
Pavlov. Cond. lever-magazine prob. diff.0.50.71.8-0.50.2-1.4
Pavlov. Cond. response bias0.40.51.4-0.30.3-1.2
Time in closed arm before self-admin0.71.32.01.41.3-0.2
Time in closed arm after self-admin0.00.00.00.0-0.1-0.1
Time in open arm before self-admin1.01.21.8-1.3-1.30.4
Time in open arm after self-admin0.10.20.3-0.6-0.2-0.4
Bone: periosteal estimation0.10.30.40.70.60.1
Bone: periosteal perimeter0.40.81.20.91.1-0.5
Bone: post-yield work5.08.713.12.63.6-2.5
Progressive ratio test 1 active lever presses0.00.00.0-0.0-0.1-0.2
Progressive ratio test 1 breakpoint0.00.00.0-0.1-0.2-0.2
Progressive ratio test 1 inactive lever presses0.00.00.10.1-0.0-0.2
Progressive ratio test 2 active lever presses0.91.32.41.51.20.4
Progressive ratio test 2 breakpoint0.91.12.11.51.10.4
Progressive ratio test 2 inactive lever presses1.85.610.33.22.31.1
Incentive Sensitization - Responses0.20.50.80.60.9-0.7
Incentive Sensitization - Breakpoint0.30.61.00.81.0-0.5
Sum of active levers in priming session hrs 5-62.92.73.7-1.2-1.91.7
Progressive ratio1.02.85.40.61.7-2.3
Food seeking constrained by brief footshock0.10.10.2-0.10.2-0.5
Seeking ratio, punishment vs. effort0.61.43.0-0.1-1.01.7
Retroperitoneal fat weight4.219.030.15.53.53.9
Reaction time number correct0.31.01.5-1.2-1.20.2
Reaction time mean minus median0.31.83.9-1.2-0.3-2.0
Reaction time mean minus median AUC0.21.62.2-1.5-0.9-1.3
Reaction time num false alarms0.60.91.4-0.9-1.20.8
Reaction time num false alarms AUC0.51.21.9-1.4-1.30.2
Reaction time trials correct on left0.31.01.5-1.2-1.20.2
Reaction time trials on left0.41.21.9-1.3-1.40.2
Reaction time mean0.20.40.50.40.7-0.6
Reaction time mean AUC0.20.50.80.60.9-0.5
Median of all reaction times0.50.81.41.01.2-0.3
Reaction time omissions1.11.92.8-1.7-1.0-1.4
Reaction time false alarm rate0.20.30.5-0.6-0.70.3
Reaction time premature initiation rate1.42.23.5-1.9-1.2-1.3
Reaction time premature initiations1.44.37.3-2.7-2.1-1.2
Std. dev. reaction times0.20.61.6-0.50.0-1.2
Reaction time trials completed0.41.21.9-1.3-1.40.2
Reaction time trials AUC0.30.91.4-1.1-1.20.2
Run reversals in cocaine runway, females0.60.61.7-0.20.5-1.3
Run reversals in cocaine runway, males0.60.71.0-0.8-1.00.6
Latency to leave start box in cocaine runway0.81.21.91.11.4-0.5
Latency to leave start box in cocaine runway, F0.70.91.40.91.2-0.7
Latency to leave start box in cocaine runway, M0.00.00.10.20.20.1
Std. dev. time between licks in bursts0.91.82.7-1.5-1.60.5
Total sessions with >9 infusions0.20.20.50.00.2-0.7
Short access day 1 total inactive lever presses0.51.01.91.40.90.7
Short access day 10 total inactive lever presses0.00.00.00.10.2-0.1
Short access day 1 total infusions0.50.91.61.31.00.2
Short access day 10 total infusions1.32.22.91.21.7-1.5
Short access total infusions0.50.80.90.71.0-0.9
Short access day 1 locomotion0.50.81.41.20.90.1
Short access day 10 total locomotion0.31.11.61.31.3-0.4
Short access total locomotion0.71.01.71.31.2-0.1
One hour access (0.3 mA shock)2.93.46.12.51.80.9
Compulsive drug intake2.33.35.5-2.3-2.1-0.3
One hour access (shock baseline)2.15.49.73.12.21.3
Social response proportion0.30.41.1-0.30.1-1.0
Social responses0.50.71.0-1.0-0.9-0.4
Social time0.30.40.7-0.8-0.5-0.6
Soleus weight1.85.210.02.30.63.2
Bone: stiffness0.91.63.70.21.1-1.9
Tibialis anterior weight6.622.838.8-6.2-5.2-1.6
Time to tail flick, vehicle, before self-admin0.91.11.40.61.2-1.2
Time to tail flick, vehicle, after self-admin0.71.43.8-0.40.5-2.0
Time to tail flick, test, before self-admin2.02.33.31.61.8-1.1
Time to tail flick, test, after self-admin0.00.00.0-0.1-0.20.1
Delta time to tail flick, vehicle, before/after SA0.50.51.0-0.7-0.3-1.0
Delta time to tail flick, test, before/after SA3.13.85.9-2.0-2.41.3
Tibia length0.61.62.6-1.3-1.60.7
Ambulatory time before self-admin0.10.40.80.50.9-0.5
Ambulatory time after self-admin0.71.11.81.31.30.0
Bone: tissue strength0.20.30.40.60.6-0.2
Total heroin consumption2.22.64.1-2.0-1.3-1.5
Bone: trabecular number1.22.23.60.61.6-1.9
Bone: trabecular spacing0.30.40.7-0.1-0.70.9
Bone: trabecular thickness1.21.62.81.31.7-0.6
Bone: trabecular tissue density2.13.77.71.80.32.8
Water consumed over 24 hours0.20.51.2-0.50.1-1.1
Number of responses in last shaping day0.10.10.2-0.4-0.5-0.1