Hub : Genes

Cfap206

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 LHb gene expression Cfap206 0.67 0.14 4.5e-14 0.4 0.38 0.4 0.39 1.3e-10 4.4e-10 1.6e-10 3.5e-10
2 IL gene expression Cfap206 0.42 0.21 4.2e-06 0.19 0.18 0.18 0.19 2.4e-05 3.6e-05 5.3e-05 3.0e-05
3 pVTA isoform ratio XM_017593532.3 0.08 0.05 1.1e-05 0.06 0.06 0.06 0.07 1.2e-05 2.5e-05 9.2e-06 2.0e-06
4 IC gene expression Cfap206 0.22 0.11 7.5e-09 0.14 0.14 0.12 0.13 2.5e-06 2.0e-06 1.0e-05 3.1e-06
5 BLA gene expression Cfap206 0.76 0.1 0.0e+00 0.52 0.66 0.64 0.64 2.0e-31 4.3e-46 9.0e-43 3.3e-43
6 NAcc gene expression Cfap206 0.8 0.04 0.0e+00 0.5 0.53 0.55 0.54 2.1e-88 4.2e-96 7.4e-101 1.4e-98
7 pVTA gene expression Cfap206 0.54 0.11 0.0e+00 0.61 0.67 0.66 0.66 2.4e-61 2.1e-71 2.1e-69 1.4e-70
8 PL gene expression Cfap206 0.27 0.11 0.0e+00 0.32 0.34 0.33 0.34 2.2e-36 1.3e-37 2.6e-37 2.2e-38
9 Brain gene expression Cfap206 0.65 0.13 0.0e+00 0.54 0.59 0.6 0.6 1.3e-58 1.7e-68 4.6e-69 2.2e-69
10 NAcc isoform ratio XM_017593532.3 0.07 0.04 4.0e-12 0.07 0.08 0.07 0.08 1.6e-11 1.3e-12 4.1e-11 3.0e-12
11 RMTg gene expression Cfap206 0.52 0.19 7.5e-13 0.44 0.38 0.43 0.43 5.6e-13 3.5e-11 1.0e-12 7.4e-13
12 NAcc alternative TSS NM_001079701.1 0.05 0.03 3.6e-09 0.05 0.06 0.05 0.05 2.3e-08 5.6e-09 2.3e-08 2.6e-08
13 pVTA alternative TSS XM_017593533.3 0.04 0.03 1.7e-04 0.04 0.04 0.04 0.05 6.5e-04 1.6e-04 1.5e-04 5.0e-05
14 pVTA alternative TSS XM_017593533.3 0.04 0.03 3.2e-04 0.04 0.04 0.05 0.05 6.8e-04 1.9e-04 7.4e-05 3.9e-05
15 Brain isoform ratio XM_017593532.3 0.03 0.02 6.8e-03 0.02 0.02 0.02 0.02 5.3e-03 2.6e-03 2.9e-03 6.3e-03
16 NAcc alternative TSS NM_001079701.1 0.05 0.03 3.0e-09 0.06 0.06 0.05 0.06 8.9e-09 4.1e-09 2.0e-08 1.0e-08
17 pVTA alternative TSS NM_001079701.1 0.04 0.03 1.0e-03 0.01 0.03 0.03 0.03 6.4e-02 1.4e-03 9.4e-04 1.6e-03
18 Brain intron excision ratio chr5_54094362_54095205 0.03 0.03 5.3e-03 0.01 0.03 0.02 0.02 1.7e-02 1.5e-03 3.5e-03 4.6e-03
19 BLA isoform ratio XM_017593532.3 0.08 0.06 2.3e-03 0.03 0.04 0.03 0.03 6.2e-03 4.9e-03 6.7e-03 8.4e-03
20 Brain intron excision ratio chr5_54094362_54095262 0.04 0.03 4.8e-03 0.01 0.03 0.02 0.02 1.8e-02 1.0e-03 2.3e-03 4.1e-03
21 pVTA alternative TSS NM_001079701.1 0.03 0.02 1.6e-03 0.01 0.03 0.04 0.03 8.4e-02 1.9e-03 7.2e-04 1.0e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
Bone: apparent density0.81.42.3-1.0-1.0-0.9-1.2-1.1-1.0-1.1-1.1-1.1-0.9-1.10.8-1.5-1.5-1.30.81.4-1.3-1.31.31.5
Area under the delay curve0.10.20.40.60.60.50.30.30.30.30.30.40.20.2-0.20.50.50.4-0.2-0.60.40.4-0.3-0.7
BMI with tail3.110.716.5-3.8-3.8-3.9-3.3-3.7-3.8-3.5-3.7-3.7-4.0-3.54.0-2.5-2.5-2.54.11.9-2.2-2.42.11.7
BMI without tail3.19.612.1-3.4-3.4-3.5-3.3-3.3-3.3-3.3-3.2-3.1-3.1-2.83.1-2.9-2.8-3.03.12.8-2.9-3.02.92.5
Body weight6.126.933.0-5.7-5.7-5.7-5.4-5.6-5.6-5.5-5.5-5.5-5.6-5.25.6-4.6-4.6-4.75.54.4-4.6-4.74.53.9
Weight adjusted by age1.32.02.3-1.5-1.5-1.4-1.4-1.4-1.3-1.4-1.4-1.4-1.3-1.41.2-1.5-1.5-1.51.21.5-1.5-1.41.41.4
Bone surface2.13.96.1-1.8-1.8-1.7-2.1-1.8-1.8-1.9-1.7-1.7-1.4-1.81.3-2.3-2.3-2.31.32.4-2.4-2.42.52.3
Bone volume1.12.03.6-1.2-1.2-1.1-1.5-1.2-1.2-1.3-1.2-1.2-0.9-1.20.8-1.7-1.7-1.80.71.7-1.9-1.81.91.8
Breakpoint value in progressive ratio session0.40.51.8-0.2-0.2-0.3-0.6-0.4-0.4-0.6-0.5-0.5-0.2-0.60.2-1.1-1.1-0.80.21.1-0.8-0.80.81.3
Number of licking bursts0.00.10.20.20.20.20.20.30.30.30.40.40.40.3-0.40.20.20.1-0.4-0.20.10.1-0.1-0.2
Context. condit. distance diff. score0.81.01.50.90.90.91.11.01.01.00.90.80.81.2-0.81.01.01.2-0.8-0.81.21.2-1.2-0.8
Locomotion velocity, session 10.20.20.50.30.30.30.50.40.40.40.30.30.20.3-0.20.50.50.6-0.2-0.70.60.6-0.6-0.7
Locomotion distance, session 13.84.85.62.42.42.42.32.32.32.42.32.22.22.1-2.22.12.12.2-2.2-2.02.12.2-2.0-1.9
Locomotion velocity, session 20.10.10.40.00.00.00.20.00.00.20.0-0.0-0.2-0.20.20.40.40.50.2-0.50.50.5-0.5-0.7
Locomotion distance, session 25.67.89.92.72.72.73.02.82.72.92.72.72.42.6-2.32.92.93.1-2.3-2.93.13.2-3.1-2.7
Locomotion velocity, session 32.62.94.61.51.51.51.91.61.61.71.61.51.31.6-1.21.81.82.1-1.2-1.82.12.1-2.1-1.8
Locomotion distance, session 33.84.16.81.71.71.72.21.91.82.01.81.71.41.9-1.32.32.32.5-1.3-2.22.62.5-2.6-2.2
Stereotopy head waving bouts, day 30.91.11.8-0.9-0.9-0.9-1.1-0.9-0.9-1.0-0.9-0.8-0.7-0.90.7-1.3-1.3-1.30.61.2-1.3-1.31.31.2
Stereotopy head waving duration, day 31.61.92.4-1.5-1.5-1.5-1.5-1.5-1.5-1.5-1.4-1.4-1.4-1.61.4-1.3-1.3-1.31.41.1-1.3-1.31.31.0
Locomotion velocity, session 70.80.92.30.70.70.71.00.70.60.90.60.50.30.6-0.21.21.21.4-0.2-1.01.51.4-1.5-1.2
Locomotion distance, session 72.22.84.51.51.51.51.81.51.41.61.51.41.11.6-1.02.02.02.1-1.0-1.72.12.1-2.1-1.8
Stereotopy head waving bouts, day 70.30.41.1-0.8-0.8-0.8-0.4-0.7-0.7-0.6-0.7-0.6-1.0-0.41.00.10.10.11.1-0.40.20.1-0.3-0.6
Stereotopy head waving duration, day 71.61.93.8-1.7-1.7-1.7-1.4-1.6-1.7-1.5-1.6-1.5-1.9-1.51.9-0.9-0.9-0.81.90.5-0.7-0.80.60.3
Locomotion velocity, session 85.76.910.92.22.22.22.82.42.32.52.22.11.82.3-1.63.03.03.2-1.6-3.23.33.2-3.3-3.2
Locomotion distance, session 87.010.212.83.13.13.13.53.33.23.43.23.12.93.3-2.83.13.13.6-2.7-2.93.63.6-3.6-2.8
Degree of sensitization distance0.30.30.5-0.6-0.6-0.6-0.6-0.6-0.7-0.6-0.7-0.6-0.7-0.70.7-0.4-0.4-0.40.70.4-0.4-0.40.30.3
Degree of sensitization stereotypy0.60.61.7-0.8-0.8-0.8-0.2-0.7-0.7-0.5-0.7-0.6-1.2-0.51.30.40.50.51.3-0.90.70.5-0.8-1.1
Conditioned locomotion0.30.30.7-0.3-0.3-0.3-0.6-0.4-0.4-0.5-0.4-0.4-0.3-0.40.2-0.7-0.7-0.70.20.8-0.7-0.70.80.8
Cocaine response after cond. corrected0.60.81.0-0.9-0.9-0.9-1.0-1.0-1.0-1.0-0.9-1.0-0.9-0.70.9-0.6-0.6-0.90.90.7-0.9-0.90.90.6
Cocaine response after cond. not corrected0.30.30.5-0.6-0.6-0.5-0.7-0.7-0.6-0.6-0.6-0.6-0.6-0.40.6-0.4-0.4-0.70.60.5-0.7-0.70.70.4
Cocaine response before conditioning0.00.00.10.20.20.20.20.20.20.30.20.30.1-0.0-0.10.10.10.3-0.1-0.20.30.3-0.2-0.3
Saline control response0.91.22.0-0.9-0.9-0.9-1.2-1.1-1.0-1.1-1.0-1.0-0.8-1.00.8-1.2-1.2-1.40.71.4-1.4-1.41.41.4
Bone: connectivity density1.21.92.8-1.2-1.2-1.1-1.4-1.3-1.3-1.3-1.3-1.4-1.2-1.51.1-1.7-1.7-1.41.11.6-1.4-1.41.41.6
Bone: cortical apparent density0.00.10.2-0.1-0.1-0.10.00.20.20.20.20.20.40.3-0.40.30.3-0.2-0.4-0.2-0.2-0.20.3-0.3
Bone: cortical area4.36.68.7-2.9-2.9-2.9-2.7-2.7-2.7-2.7-2.6-2.6-2.6-2.62.5-2.4-2.4-2.52.52.2-2.5-2.52.52.0
Bone: cortical porosity0.30.31.00.00.00.0-0.4-0.10.0-0.20.00.10.2-0.1-0.3-0.7-0.7-0.8-0.41.0-1.0-0.81.01.0
Bone: cortical porosity0.80.81.7-0.7-0.7-0.7-1.0-0.8-0.7-0.8-0.7-0.6-0.5-0.80.5-1.1-1.1-1.20.41.2-1.3-1.21.31.2
Bone: cortical thickness1.01.62.9-1.7-1.7-1.7-1.4-1.4-1.4-1.3-1.3-1.3-1.3-1.11.3-0.8-0.8-1.21.30.8-1.2-1.21.20.5
Bone: cortical thickness0.20.30.7-0.6-0.6-0.6-0.3-0.5-0.6-0.4-0.6-0.7-0.8-0.50.80.20.20.10.9-0.40.20.1-0.2-0.6
Bone: cortical tissue density0.10.10.2-0.0-0.00.00.10.20.20.20.30.20.40.4-0.40.30.3-0.1-0.5-0.3-0.2-0.20.2-0.3
Condit. Reinf. active minus inactive responses2.93.34.01.81.81.81.91.81.81.81.71.81.61.5-1.52.01.91.9-1.5-2.01.91.9-1.9-1.9
Condit. Reinf. active-inactive response ratio0.70.71.00.80.80.80.90.90.90.90.91.00.80.7-0.80.90.90.8-0.8-0.90.80.8-0.8-0.8
Condit. Reinf. active responses1.92.43.31.41.41.41.71.51.51.61.41.51.21.2-1.21.71.71.8-1.2-1.71.81.8-1.8-1.7
Condit. Reinf. inactive responses0.91.11.81.01.01.01.21.00.91.10.90.90.80.8-0.71.11.11.3-0.7-1.31.31.3-1.4-1.1
Incentive salience index mean1.11.31.81.11.11.11.21.11.11.21.01.10.90.8-0.91.31.31.3-0.8-1.31.31.3-1.3-1.3
Condit. Reinf. lever presses0.10.10.20.10.10.10.20.00.00.10.00.1-0.1-0.00.20.30.30.40.2-0.30.50.4-0.5-0.4
Condit. Reinf. active minus inactive responses0.40.61.1-0.9-0.9-0.9-0.7-0.9-0.8-0.7-0.9-0.9-1.0-0.91.0-0.5-0.5-0.41.00.3-0.4-0.30.40.2
Condit. Reinf. active-inactive response ratio0.30.41.0-0.3-0.3-0.30.1-0.2-0.3-0.0-0.3-0.3-0.7-0.30.70.70.70.70.8-0.90.80.8-0.9-1.0
Condit. Reinf. active responses0.91.31.7-1.1-1.1-1.1-1.2-1.2-1.0-1.0-1.1-1.1-1.0-1.21.0-1.3-1.2-1.10.91.2-1.3-1.11.31.1
Condit. Reinf. inactive responses0.91.22.8-0.7-0.7-0.7-1.1-0.8-0.7-0.9-0.7-0.7-0.5-0.80.4-1.4-1.4-1.40.31.5-1.6-1.41.71.5
Condit. Reinf. lever presses1.31.82.5-1.4-1.4-1.4-1.4-1.4-1.4-1.3-1.5-1.5-1.5-1.61.4-1.4-1.4-1.11.41.2-1.1-1.11.11.1
Condit. Reinf. lever reinforcers received1.21.72.1-1.3-1.3-1.3-1.4-1.3-1.2-1.2-1.3-1.3-1.2-1.41.2-1.5-1.5-1.31.11.4-1.4-1.31.41.3
Conditioned reinforcement - actives0.30.50.9-0.9-0.9-1.0-0.6-0.7-0.7-0.7-0.8-0.7-0.8-0.70.8-0.8-0.8-0.40.80.5-0.4-0.40.40.5
Conditioned reinforcement - inactives0.00.00.1-0.1-0.1-0.20.10.10.30.20.10.10.10.2-0.1-0.1-0.00.2-0.10.30.00.1-0.00.0
Conditioned locomotion1.21.62.0-1.3-1.3-1.4-1.2-1.2-1.2-1.3-1.4-1.4-1.3-1.21.3-1.4-1.4-1.01.31.4-0.9-1.00.91.3
Patch foraging indifference point 0 sec0.10.20.7-0.2-0.2-0.1-0.4-0.4-0.3-0.4-0.3-0.3-0.3-0.50.3-0.8-0.8-0.50.30.7-0.5-0.50.50.8
Patch foraging indifference point AUC1.92.73.7-1.9-1.9-1.8-1.6-1.7-1.8-1.7-1.8-1.9-1.7-1.61.7-1.6-1.6-1.51.71.5-1.4-1.41.31.4
Delay disc. indifference point, 0s delay0.50.61.30.50.50.50.70.60.60.70.60.60.40.8-0.31.01.10.9-0.3-1.00.90.9-0.9-1.1
Delay disc. indifference point, 16s delay0.10.10.1-0.0-0.0-0.2-0.3-0.4-0.3-0.3-0.2-0.1-0.4-0.40.3-0.0-0.0-0.30.30.0-0.4-0.30.4-0.1
Delay disc. indifference point, 2s delay0.10.10.2-0.2-0.2-0.3-0.4-0.3-0.3-0.4-0.3-0.2-0.3-0.20.3-0.2-0.2-0.40.30.4-0.4-0.40.40.3
Delay disc. indifference point, 24s delay0.00.00.00.10.10.1-0.1-0.1-0.1-0.1-0.00.1-0.20.00.10.10.1-0.00.10.2-0.1-0.00.1-0.0
Delay disc. indifference point, 4s delay0.40.50.90.90.90.90.70.60.60.70.60.60.60.6-0.60.70.70.7-0.5-0.70.70.7-0.6-0.7
Delay disc. indifference point, 8s delay0.00.00.10.30.30.20.10.10.20.10.20.20.1-0.1-0.10.10.10.1-0.1-0.20.00.10.0-0.2
Indifference point function ln k0.30.50.90.80.80.70.70.60.70.70.70.80.50.5-0.50.80.80.8-0.5-1.00.80.8-0.8-0.9
Indifference point function log k0.30.50.90.80.80.70.70.60.70.70.70.80.50.5-0.50.80.80.8-0.5-1.00.80.8-0.8-0.9
Patch foraging total patch changes 0 sec0.10.10.3-0.1-0.1-0.0-0.3-0.3-0.2-0.3-0.2-0.1-0.3-0.40.3-0.5-0.5-0.30.30.4-0.3-0.20.30.5
Patch foraging total patch changes 12 sec0.81.12.3-1.1-1.1-1.1-0.9-1.2-1.2-1.1-1.3-1.3-1.4-1.41.5-0.8-0.8-0.51.50.4-0.4-0.40.30.4
Patch foraging total patch changes 18 sec0.20.30.6-0.6-0.6-0.3-0.5-0.5-0.5-0.5-0.3-0.3-0.4-0.40.4-0.7-0.7-0.50.40.8-0.5-0.50.50.7
Patch foraging total patch changes 24 sec1.01.82.8-1.1-1.1-1.1-1.3-1.2-1.2-1.3-1.2-1.3-1.1-1.41.1-1.6-1.6-1.41.11.6-1.4-1.41.41.7
Patch foraging total patch changes 6 sec0.30.51.1-0.6-0.6-0.5-0.7-0.6-0.6-0.6-0.6-0.6-0.5-0.60.5-0.9-0.9-0.70.51.0-0.7-0.70.71.1
Patch foraging time to switch 0 sec1.22.53.41.81.81.71.61.71.81.71.71.71.81.6-1.81.31.31.4-1.8-1.21.31.3-1.2-1.1
Patch foraging water rate 0 sec1.02.22.7-1.6-1.6-1.5-1.5-1.6-1.6-1.5-1.5-1.5-1.6-1.61.6-1.4-1.4-1.31.61.4-1.3-1.31.31.2
Patch foraging water rate 12 sec0.30.61.0-0.9-0.9-0.8-0.7-0.9-0.8-0.7-0.6-0.6-0.9-0.80.9-0.7-0.6-0.50.91.0-0.5-0.50.50.7
Patch foraging water rate 18 sec0.30.41.0-0.8-0.8-0.7-0.1-0.5-0.6-0.2-0.5-0.4-0.9-0.41.00.60.60.51.0-0.60.60.6-0.6-1.0
Patch foraging water rate 24 sec0.40.52.1-0.2-0.2-0.20.40.0-0.10.30.10.1-0.4-0.20.50.90.91.00.5-1.31.01.0-1.1-1.5
Patch foraging water rate 6 sec0.40.61.4-1.1-1.1-1.0-0.7-1.0-1.0-0.8-0.8-0.7-1.2-0.81.2-0.2-0.2-0.31.20.3-0.3-0.30.30.0
Seeking ratio, delayed vs. immediate footshock0.10.20.50.10.10.0-0.3-0.1-0.1-0.1-0.2-0.20.0-0.6-0.1-0.7-0.7-0.5-0.10.6-0.5-0.40.50.7
Distance traveled before self-admin0.00.10.1-0.2-0.2-0.2-0.0-0.1-0.2-0.2-0.2-0.2-0.3-0.30.3-0.3-0.30.10.30.10.20.1-0.30.3
Distance traveled after self-admin0.10.10.40.30.30.30.40.30.30.40.40.40.10.3-0.10.20.20.6-0.1-0.10.60.6-0.6-0.2
Extensor digitorum longus weight4.417.321.3-4.6-4.6-4.6-4.3-4.5-4.5-4.3-4.4-4.4-4.4-4.34.4-3.7-3.7-3.84.33.7-3.7-3.83.73.2
Bone: elastic displacement0.10.20.40.40.40.40.20.40.50.30.50.60.60.4-0.6-0.3-0.3-0.1-0.70.3-0.2-0.10.20.4
Bone: elastic work1.82.43.7-1.4-1.4-1.4-1.6-1.4-1.4-1.5-1.4-1.3-1.1-1.41.1-1.9-1.9-1.71.11.8-1.8-1.71.81.8
Bone: endosteal estimation4.59.911.4-3.3-3.3-3.2-3.2-3.3-3.3-3.2-3.2-3.1-3.2-3.43.2-3.3-3.3-2.93.23.1-2.8-2.82.73.0
Bone: endosteal perimeter3.26.98.7-2.6-2.6-2.6-2.7-2.6-2.7-2.7-2.6-2.5-2.4-2.72.4-2.9-2.9-2.62.42.9-2.5-2.52.42.9
Epididymis fat weight0.00.10.30.10.10.0-0.2-0.1-0.1-0.2-0.1-0.00.10.1-0.1-0.1-0.1-0.5-0.10.3-0.5-0.50.50.4
Delta time in closed arm before/after self-admin0.00.00.10.20.20.10.00.10.10.00.10.10.20.1-0.20.20.2-0.1-0.2-0.4-0.1-0.10.1-0.2
Delta time in open arm before/after self-admin0.30.30.90.10.10.20.50.30.30.40.30.30.10.2-0.00.70.70.7-0.0-0.90.70.7-0.7-1.0
Diff in mean of infusions in LGA sessions1.11.42.51.51.51.61.21.41.41.21.31.31.51.1-1.50.70.70.8-1.5-0.60.80.8-0.8-0.4
Delay discount exponential model param0.20.20.5-0.7-0.7-0.6-0.4-0.3-0.4-0.4-0.4-0.5-0.2-0.30.3-0.6-0.6-0.50.30.7-0.4-0.50.40.7
Extinction: sum of active levers before priming1.21.31.81.21.21.21.21.11.01.11.01.00.90.8-0.81.11.11.3-0.8-1.31.31.3-1.3-1.2
Active lever presses in extinction session 60.90.91.71.31.31.30.91.01.21.01.11.11.11.1-1.10.90.90.7-1.1-0.60.50.6-0.5-0.7
Bone: final force2.84.44.8-2.1-2.1-2.2-2.2-2.1-2.1-2.2-2.1-2.1-2.0-2.22.0-2.2-2.2-2.12.02.1-2.0-2.12.02.1
Bone: final moment3.75.96.4-2.5-2.5-2.5-2.5-2.5-2.5-2.5-2.5-2.4-2.3-2.52.3-2.5-2.5-2.42.22.3-2.4-2.42.42.3
Food consumed during 24 hour testing period1.62.22.6-1.4-1.4-1.4-1.6-1.6-1.6-1.6-1.6-1.6-1.5-1.51.5-1.4-1.4-1.51.51.3-1.5-1.51.51.1
Glucose0.10.10.3-0.4-0.4-0.4-0.3-0.3-0.3-0.3-0.3-0.2-0.3-0.10.3-0.4-0.4-0.20.30.5-0.2-0.20.20.5
Heart weight2.33.64.4-2.0-2.0-2.1-2.0-2.1-2.1-2.0-2.0-1.9-2.0-1.61.9-1.7-1.7-1.81.91.9-1.8-1.81.81.6
Delay discount hyperbolic model param0.10.10.2-0.5-0.5-0.3-0.2-0.1-0.2-0.2-0.2-0.3-0.1-0.10.1-0.4-0.4-0.20.10.4-0.2-0.20.20.4
Intermittent access intake day 1-15 change1.02.02.61.61.61.51.41.41.51.51.41.41.31.2-1.31.41.41.4-1.3-1.31.31.4-1.3-1.4
Intermittent access intake escalation0.91.92.61.61.61.61.41.41.41.51.31.41.31.2-1.31.51.51.3-1.3-1.31.21.3-1.2-1.4
Intermittent access intake escalation 21.41.72.51.41.41.31.31.21.11.31.11.10.90.9-0.91.41.41.5-0.9-1.51.51.6-1.5-1.5
Intermitt. access day 1 inactive lever presses0.10.41.6-0.1-0.1-0.10.40.20.20.20.30.30.10.5-0.01.21.20.5-0.0-1.10.60.5-0.7-1.2
Intermitt. access day 15 inactive lever presses0.00.00.20.20.20.1-0.10.00.10.10.10.10.20.2-0.20.30.3-0.2-0.30.0-0.4-0.20.4-0.3
Intermitt. access escalation Index0.10.20.40.50.50.50.20.40.40.30.40.40.60.3-0.6-0.1-0.1-0.1-0.70.3-0.1-0.10.20.4
Intermittent access day 1 total infusions0.61.01.5-1.0-1.0-1.1-1.0-1.1-1.0-1.0-1.1-1.0-1.0-0.81.0-0.9-0.9-0.81.01.2-0.9-0.80.90.9
Intermittent access day 15 total infusions0.00.00.1-0.0-0.0-0.2-0.2-0.3-0.2-0.1-0.3-0.3-0.4-0.20.30.10.10.10.30.2-0.00.10.0-0.1
Intermittent access terminal intake (last 3 days)0.00.10.20.40.40.20.20.10.10.30.00.1-0.00.20.00.30.40.4-0.00.00.30.4-0.3-0.4
Intermittent access total infusions0.60.71.1-0.8-0.8-0.9-0.9-1.0-1.0-0.8-1.1-1.0-1.1-1.01.1-0.7-0.7-0.61.01.0-0.6-0.50.60.6
Intermittent access day 1 locomotion0.70.92.4-0.7-0.7-0.8-0.9-0.7-0.6-0.8-0.7-0.7-0.4-0.40.4-1.1-1.1-1.10.31.5-1.2-1.21.31.4
Intermittent access day 15 total locomotion0.30.61.8-0.6-0.6-0.6-0.7-0.6-0.5-0.6-0.5-0.5-0.3-0.50.3-1.0-1.0-0.90.31.4-1.0-0.91.01.2
Intermittent access total locomotion0.60.82.1-0.6-0.6-0.7-0.8-0.7-0.6-0.7-0.6-0.6-0.4-0.50.3-1.2-1.2-1.00.31.4-1.1-1.01.11.3
Intermittent access standard deviation0.20.31.00.40.40.30.60.40.30.60.20.30.10.2-0.10.70.70.9-0.1-0.60.91.0-0.9-0.9
Left kidney weight2.210.413.7-3.7-3.7-3.7-3.3-3.4-3.5-3.4-3.4-3.5-3.5-3.03.5-2.9-2.9-2.83.43.1-2.7-2.82.62.7
Right kidney weight1.98.810.6-3.2-3.2-3.2-3.2-3.3-3.1-3.1-3.1-3.1-3.1-2.73.1-2.6-2.6-2.83.02.9-2.8-2.82.82.3
Cocaine induced anxiety0.30.41.10.50.50.50.80.70.60.60.50.50.50.5-0.40.40.40.8-0.4-0.71.00.9-1.1-0.4
Post-drug Anxiety0.00.00.1-0.3-0.3-0.30.1-0.0-0.1-0.1-0.1-0.1-0.1-0.20.2-0.0-0.00.20.2-0.20.30.2-0.3-0.0
Baseline Anxiety0.00.10.2-0.2-0.2-0.3-0.3-0.2-0.2-0.2-0.2-0.2-0.2-0.10.10.00.1-0.30.10.1-0.4-0.30.4-0.1
Tail length1.97.312.5-2.4-2.4-2.4-2.9-2.5-2.3-2.5-2.3-2.3-1.8-1.91.7-2.9-2.9-3.31.63.5-3.5-3.33.53.2
Length with tail3.314.418.5-3.8-3.8-3.7-4.0-3.8-3.7-3.8-3.7-3.7-3.4-3.53.2-4.0-3.9-4.03.24.3-4.1-4.04.13.9
Length without tail1.44.46.4-2.3-2.3-2.3-2.2-2.4-2.4-2.2-2.4-2.4-2.5-2.32.5-1.6-1.6-1.72.51.6-1.6-1.61.61.3
Times rat made contact with spout0.10.10.50.00.00.0-0.4-0.2-0.1-0.3-0.1-0.10.00.0-0.1-0.2-0.2-0.6-0.10.6-0.7-0.60.70.5
Lifetime Intake0.60.71.2-0.9-0.9-1.0-0.8-1.0-1.0-0.8-1.0-1.0-1.1-0.91.1-0.7-0.6-0.51.10.9-0.5-0.40.50.5
Liver weight, left2.84.77.6-1.9-1.9-1.9-2.3-2.0-1.9-2.1-1.8-1.7-1.5-1.71.4-2.6-2.6-2.61.32.8-2.7-2.72.72.7
Liver weight, right1.32.33.4-1.4-1.4-1.4-1.7-1.6-1.4-1.6-1.4-1.4-1.3-1.21.2-1.6-1.6-1.81.21.8-1.8-1.81.81.6
Locomotor activity0.60.91.51.21.21.10.91.01.00.91.11.20.91.1-0.90.90.80.8-0.9-0.90.80.8-0.8-0.7
Locomotor testing distance0.20.30.70.60.60.60.50.60.60.50.70.80.70.7-0.60.40.40.4-0.6-0.50.40.4-0.4-0.3
Locomotor testing rearing0.71.31.81.11.11.21.21.21.21.21.31.31.11.2-1.11.21.11.1-1.1-1.21.11.1-1.1-1.1
Locomotion in novel chamber0.50.71.4-0.5-0.5-0.7-0.7-0.7-0.7-0.8-0.9-0.9-0.7-1.20.7-1.2-1.2-0.80.70.8-0.6-0.70.61.1
Locomotion in novel chamber post-restriction0.30.41.01.01.00.70.60.70.80.60.70.60.90.4-0.90.50.50.3-0.9-0.60.30.3-0.3-0.4
Fecal boli incidents, locomotor time 10.30.40.8-0.4-0.4-0.5-0.6-0.5-0.5-0.6-0.5-0.6-0.3-0.20.2-0.7-0.7-0.80.20.9-0.9-0.90.90.9
Change in fecal boli incidents, locomotor task0.10.10.40.40.40.50.20.30.50.30.40.40.60.1-0.6-0.1-0.1-0.1-0.60.0-0.2-0.10.20.1
Time >=10cm from walls, locomotor time 10.10.10.9-0.1-0.1-0.1-0.3-0.3-0.2-0.1-0.2-0.1-0.3-0.20.3-0.6-0.6-0.10.21.0-0.3-0.10.30.7
Bouts of movement, locomotor time 10.20.30.50.60.60.50.50.50.50.50.50.50.60.4-0.60.60.60.4-0.6-0.70.40.4-0.4-0.6
Total resting periods, locomotor time 10.00.10.20.30.30.30.10.20.20.10.20.30.40.2-0.40.10.1-0.1-0.4-0.1-0.2-0.20.2-0.1
Rest time, locomotor task time 10.10.10.30.40.40.40.20.30.30.20.20.20.50.4-0.50.40.4-0.0-0.6-0.0-0.1-0.10.1-0.1
Distance moved, locomotor task time 10.20.30.8-0.6-0.6-0.6-0.4-0.5-0.6-0.6-0.6-0.6-0.8-0.90.8-0.6-0.6-0.10.9-0.10.1-0.1-0.10.2
Vertical activity count, locomotor time 10.00.10.4-0.1-0.1-0.10.1-0.0-0.1-0.0-0.1-0.2-0.3-0.10.40.10.10.40.4-0.60.50.4-0.6-0.4
Time >=10cm from walls, locomotor time 21.31.93.6-1.3-1.3-1.2-1.4-1.4-1.3-1.2-1.2-1.3-1.3-1.21.2-1.7-1.6-1.31.11.9-1.4-1.31.41.6
Bouts of movement, locomotor time 20.00.00.10.10.10.30.10.10.10.20.10.10.20.2-0.20.30.30.1-0.2-0.30.00.1-0.0-0.3
Total resting periods, locomotor time 20.00.10.20.20.20.30.10.20.10.20.10.10.20.2-0.30.40.40.1-0.3-0.40.10.1-0.0-0.4
Rest time, locomotor task time 20.40.51.11.01.00.90.70.90.80.80.70.60.90.5-1.00.40.40.5-0.9-0.60.50.5-0.4-0.3
Distance moved, locomotor task time 20.20.20.9-0.1-0.1-0.10.2-0.1-0.1-0.0-0.1-0.0-0.5-0.30.60.30.20.70.7-0.70.90.7-0.9-0.6
Vertical activity count, locomotor time 20.30.41.4-0.9-0.9-0.8-0.4-0.7-0.7-0.6-0.7-0.7-1.1-0.61.2-0.2-0.20.11.2-0.20.20.1-0.3-0.2
Light reinforcement 11.12.85.2-2.2-2.2-2.1-1.5-1.8-2.0-1.7-2.0-2.0-2.2-1.92.3-1.2-1.2-0.92.30.8-0.6-0.80.50.7
Light reinforcement 21.62.44.1-2.0-2.0-2.0-1.5-1.7-1.8-1.6-1.8-1.8-1.9-1.61.9-1.1-1.1-1.02.00.9-0.9-0.90.80.7
Bone: marrow area4.610.011.6-3.3-3.3-3.3-3.2-3.3-3.3-3.2-3.3-3.2-3.2-3.43.2-3.3-3.3-2.93.23.1-2.8-2.92.83.0
Bone: maximum diameter4.88.99.8-3.1-3.1-3.0-3.1-3.0-3.0-3.0-2.9-2.8-2.7-3.02.6-3.1-3.1-3.12.63.1-3.1-3.13.13.0
Bone: maximum force3.86.88.0-2.8-2.8-2.8-2.7-2.8-2.8-2.8-2.8-2.8-2.8-2.82.7-2.4-2.4-2.52.72.1-2.4-2.42.32.1
Bone: maximum moment4.68.09.3-3.0-3.0-3.0-3.0-3.0-3.0-3.0-3.0-2.9-2.9-3.02.9-2.7-2.7-2.72.92.4-2.7-2.72.62.3
Mean time between licks in bursts0.20.50.9-0.9-0.9-0.9-0.7-0.8-0.8-0.7-0.8-0.8-0.8-0.90.8-0.5-0.5-0.60.80.3-0.5-0.50.50.2
Mean num. licks in bursts0.10.10.3-0.3-0.3-0.3-0.4-0.4-0.3-0.4-0.4-0.4-0.3-0.20.3-0.3-0.3-0.40.30.6-0.5-0.40.50.5
Cd content in liver2.83.14.2-2.1-2.1-2.1-1.9-1.9-2.0-1.9-1.9-1.8-1.9-1.81.9-1.4-1.4-1.71.91.2-1.7-1.71.61.1
Co content in liver0.10.10.3-0.2-0.2-0.2-0.4-0.3-0.2-0.3-0.2-0.2-0.2-0.20.1-0.4-0.4-0.50.10.4-0.5-0.50.60.4
Cu content in liver0.00.00.10.10.10.10.10.20.20.10.20.30.30.0-0.3-0.1-0.1-0.1-0.30.1-0.1-0.10.10.2
Fe content in liver0.30.31.00.10.10.1-0.30.10.2-0.00.20.30.50.2-0.6-0.5-0.5-0.8-0.70.8-1.0-0.91.00.9
K content in liver1.11.01.41.11.11.11.01.11.11.11.11.11.21.1-1.21.01.00.8-1.2-0.90.70.8-0.7-0.8
Mg content in liver0.10.10.20.30.30.30.30.40.40.30.40.40.40.4-0.50.30.30.2-0.5-0.30.10.1-0.1-0.2
Mn content in liver0.20.20.3-0.4-0.4-0.4-0.5-0.4-0.4-0.4-0.4-0.5-0.3-0.30.3-0.4-0.4-0.50.30.5-0.6-0.50.60.4
Na content in liver1.82.03.01.51.51.51.41.61.61.51.61.61.71.6-1.71.21.21.0-1.7-1.10.91.0-0.9-0.9
Rb content in liver0.70.81.20.90.90.90.91.01.00.90.90.91.11.1-1.10.90.90.7-1.1-0.90.60.6-0.6-0.7
Se content in liver1.72.13.31.61.61.61.41.61.61.51.61.71.81.7-1.81.21.21.1-1.8-0.80.91.0-0.9-0.8
Sr content in liver1.81.51.91.31.31.31.41.31.31.31.31.31.21.2-1.21.11.11.3-1.1-1.01.41.3-1.4-0.9
Zn content in liver0.10.10.2-0.4-0.4-0.4-0.3-0.3-0.4-0.3-0.3-0.2-0.4-0.40.5-0.2-0.2-0.10.50.2-0.1-0.10.00.2
Bone: minimum diameter1.93.54.4-2.1-2.1-2.1-1.9-2.0-2.0-1.9-1.9-1.9-2.0-1.92.0-1.8-1.8-1.62.01.7-1.6-1.61.51.6
Time in familiar zone, hab. session 11.31.21.6-1.2-1.2-1.2-1.2-1.2-1.2-1.2-1.2-1.3-1.1-0.81.1-0.9-0.9-1.11.11.0-1.1-1.11.10.8
Time in novel zone, hab. session 14.64.66.42.02.02.02.32.12.02.12.02.11.71.9-1.62.42.42.4-1.6-2.52.52.4-2.5-2.4
Total zone transitions, hab. session 18.111.316.63.83.83.83.33.73.83.63.83.84.04.0-4.02.82.82.6-4.1-2.12.32.5-2.2-2.1
Total locomotion distance, hab. session 14.96.913.13.23.23.22.53.03.12.83.13.13.53.1-3.61.71.71.6-3.6-0.91.31.5-1.1-0.8
Locomotion velocity, hab. session 13.44.810.42.72.72.72.02.52.62.32.72.73.12.6-3.21.11.11.1-3.2-0.40.71.0-0.6-0.3
Time in familiar zone, hab. session 20.10.10.20.10.10.10.20.00.00.10.0-0.1-0.20.00.20.30.30.40.2-0.30.40.5-0.4-0.4
Time in novel zone, hab. session 20.00.00.0-0.1-0.1-0.1-0.1-0.0-0.1-0.1-0.1-0.0-0.0-0.20.0-0.1-0.1-0.10.1-0.1-0.0-0.10.00.1
Total zone transitions, hab. session 24.55.86.52.62.62.62.52.62.52.52.52.52.52.5-2.42.22.22.4-2.4-2.12.32.3-2.3-2.0
Total locomotion distance, hab. session 21.11.53.11.51.51.51.21.41.51.31.51.41.71.2-1.70.40.40.7-1.7-0.00.60.7-0.50.1
Locomotion velocity, hab. session 20.81.12.71.31.31.30.91.21.31.11.31.31.51.1-1.60.20.20.4-1.60.20.30.4-0.20.3
Novel to familiar place preference ratio0.40.51.5-0.1-0.1-0.1-0.5-0.10.0-0.30.10.10.40.4-0.5-0.8-0.8-1.0-0.51.2-1.2-1.21.21.1
Novelty place preference0.40.41.00.30.30.3-0.10.30.40.00.40.40.80.7-0.9-0.5-0.5-0.8-0.90.9-0.9-0.91.00.9
Time in novel zone, NPP test0.40.41.00.40.40.4-0.00.40.50.20.50.50.90.9-1.0-0.4-0.4-0.6-1.00.8-0.8-0.70.80.8
Total zone transitions, NPP test3.34.75.62.22.22.22.32.22.12.22.12.02.02.3-1.92.42.42.3-1.9-2.32.32.2-2.3-2.2
Total locomotion distance, NPP test0.60.81.21.11.11.11.01.11.01.01.00.91.00.8-1.00.60.60.9-1.0-0.60.90.9-0.9-0.4
Locomotion velocity, NPP test0.30.40.70.80.80.80.70.80.70.70.70.70.80.5-0.80.30.30.6-0.8-0.30.60.6-0.6-0.2
Intraocular pressure2.02.94.1-1.4-1.4-1.5-1.8-1.7-1.6-1.8-1.7-1.8-1.5-2.01.5-2.0-2.0-1.91.51.5-1.8-1.81.71.7
Delta distance traveled before/after self-admin0.10.10.20.30.30.30.20.20.40.30.40.40.30.4-0.30.20.20.2-0.30.20.10.2-0.1-0.1
Delta ambulatory time before/after self-admin0.20.20.40.60.60.50.40.50.50.60.60.60.50.6-0.60.40.40.4-0.6-0.10.20.4-0.2-0.2
Parametrial fat weight0.71.63.01.11.11.11.41.11.11.21.21.20.81.2-0.81.41.41.7-0.7-1.31.71.7-1.7-1.4
Pavlov. Cond. lever latency0.40.51.10.60.60.60.70.70.70.70.60.60.50.5-0.50.80.80.8-0.5-1.00.80.8-0.8-0.9
Pavlov. Cond. magazine entry latency0.40.51.9-0.2-0.2-0.2-0.5-0.2-0.1-0.4-0.1-0.10.2-0.2-0.3-1.0-1.0-1.0-0.31.3-1.0-1.01.11.4
Pavlov. Cond. change in total contacts0.10.10.30.40.40.40.30.40.40.30.50.50.50.4-0.50.10.00.1-0.50.20.10.1-0.10.2
Pavlov. Cond. index score0.30.41.2-0.2-0.2-0.2-0.5-0.3-0.3-0.4-0.3-0.2-0.0-0.2-0.0-0.8-0.8-0.8-0.01.1-0.9-0.90.91.1
Pavlov. Cond. latency score0.50.61.6-0.5-0.5-0.5-0.7-0.5-0.5-0.6-0.5-0.4-0.2-0.50.2-1.0-1.0-1.00.11.3-1.1-1.11.11.3
Pavlov. Cond. lever contacts0.50.61.5-0.6-0.6-0.6-0.8-0.6-0.6-0.7-0.6-0.5-0.4-0.50.4-0.9-0.9-0.90.41.2-1.0-1.01.01.1
Pavlov. Cond. magazine entry number0.50.62.10.40.40.40.70.40.30.60.40.30.00.4-0.01.11.11.1-0.0-1.31.11.1-1.1-1.4
Pavlov. Cond. intertrial magazine entries2.32.84.51.41.41.41.71.51.51.71.51.31.21.5-1.22.12.11.9-1.2-2.01.81.9-1.8-2.1
Pavlov. Cond. lever-magazine prob. diff.0.20.20.8-0.2-0.2-0.2-0.4-0.2-0.2-0.3-0.2-0.10.0-0.1-0.1-0.6-0.6-0.6-0.10.9-0.7-0.70.70.9
Pavlov. Cond. response bias0.40.51.7-0.3-0.3-0.3-0.6-0.3-0.3-0.5-0.3-0.2-0.0-0.30.0-0.9-0.9-0.9-0.01.3-0.9-0.90.91.3
Pavlov. Cond. lever latency0.50.71.00.80.80.80.80.90.90.80.90.81.00.9-1.00.80.80.6-1.0-0.90.50.6-0.5-0.8
Pavlov. Cond. magazine entry latency0.50.71.10.90.90.90.90.90.90.90.91.00.90.8-0.90.60.60.8-0.9-0.40.70.8-0.7-0.4
Pavlov. Cond. change in total contacts0.20.30.5-0.5-0.5-0.5-0.5-0.6-0.6-0.5-0.6-0.6-0.7-0.70.7-0.6-0.6-0.30.70.6-0.3-0.30.20.6
Pavlov. Cond. index score0.00.00.2-0.0-0.0-0.0-0.1-0.1-0.1-0.1-0.1-0.0-0.2-0.10.2-0.2-0.20.00.20.40.00.0-0.00.3
Pavlov. Cond. latency score0.30.40.9-0.6-0.6-0.5-0.6-0.6-0.6-0.6-0.6-0.5-0.6-0.60.6-0.7-0.7-0.50.60.9-0.5-0.50.50.8
Pavlov. Cond. lever contacts0.30.50.7-0.6-0.6-0.6-0.7-0.8-0.7-0.7-0.7-0.7-0.8-0.80.8-0.7-0.7-0.50.80.8-0.5-0.50.40.7
Pavlov. Cond. magazine entry number0.30.30.5-0.6-0.6-0.6-0.6-0.5-0.5-0.6-0.6-0.7-0.4-0.50.4-0.5-0.5-0.70.40.3-0.7-0.70.70.4
Pavlov. Cond. intertrial magazine entries0.00.10.3-0.1-0.1-0.1-0.2-0.1-0.0-0.1-0.0-0.10.1-0.0-0.1-0.1-0.1-0.4-0.10.2-0.5-0.40.60.2
Pavlov. Cond. lever-magazine prob. diff.0.00.00.1-0.0-0.0-0.0-0.0-0.1-0.1-0.0-0.00.0-0.2-0.10.2-0.2-0.20.10.10.40.10.1-0.10.3
Pavlov. Cond. response bias0.00.00.20.20.20.20.20.10.10.10.10.1-0.1-0.00.10.10.10.30.10.00.40.4-0.4-0.0
Time in closed arm before self-admin1.51.93.3-1.6-1.6-1.6-1.3-1.5-1.5-1.5-1.6-1.5-1.7-1.61.8-1.3-1.3-0.91.81.0-0.7-0.80.61.0
Time in closed arm after self-admin0.50.50.7-0.7-0.7-0.8-0.7-0.7-0.8-0.8-0.9-0.8-0.7-0.90.7-0.6-0.7-0.70.70.3-0.6-0.70.60.5
Time in open arm before self-admin0.40.41.30.10.10.1-0.40.00.0-0.10.10.10.50.2-0.6-0.6-0.6-0.9-0.71.1-1.0-0.91.11.0
Time in open arm after self-admin0.20.30.40.50.50.60.50.50.50.60.60.60.60.6-0.60.50.60.4-0.6-0.30.30.4-0.2-0.5
Bone: periosteal estimation6.213.115.8-4.0-4.0-3.9-3.7-3.8-3.8-3.7-3.7-3.7-3.7-3.83.6-3.6-3.6-3.43.63.3-3.3-3.43.33.2
Bone: periosteal perimeter6.911.813.0-3.6-3.6-3.6-3.6-3.5-3.5-3.5-3.4-3.3-3.2-3.53.2-3.6-3.6-3.43.13.5-3.4-3.43.33.4
Bone: post-yield work0.81.21.5-1.1-1.1-1.1-1.2-1.2-1.2-1.2-1.2-1.2-1.2-1.11.2-0.9-0.9-1.11.20.9-1.1-1.11.10.8
Progressive ratio test 1 active lever presses0.30.30.8-0.6-0.6-0.6-0.6-0.6-0.5-0.5-0.6-0.6-0.6-0.50.5-0.6-0.6-0.50.50.9-0.6-0.50.60.6
Progressive ratio test 1 breakpoint0.20.30.6-0.6-0.6-0.6-0.6-0.6-0.5-0.5-0.6-0.6-0.6-0.50.6-0.6-0.5-0.40.50.8-0.5-0.40.50.5
Progressive ratio test 1 inactive lever presses0.60.81.20.80.80.70.91.01.01.01.01.01.11.1-1.01.01.00.8-1.1-0.60.60.7-0.6-0.8
Progressive ratio test 2 active lever presses0.10.10.3-0.5-0.5-0.6-0.3-0.4-0.4-0.3-0.5-0.4-0.5-0.30.5-0.1-0.1-0.20.50.1-0.2-0.10.2-0.1
Progressive ratio test 2 breakpoint0.10.10.4-0.5-0.5-0.6-0.3-0.4-0.4-0.3-0.5-0.4-0.5-0.30.5-0.0-0.0-0.10.50.1-0.1-0.10.1-0.1
Progressive ratio test 2 inactive lever presses0.00.00.10.10.10.0-0.00.10.20.10.10.10.20.1-0.20.00.0-0.2-0.30.1-0.3-0.20.30.0
Incentive Sensitization - Responses0.00.00.30.10.10.00.20.10.10.10.10.10.10.2-0.00.30.30.2-0.0-0.50.20.2-0.2-0.4
Incentive Sensitization - Breakpoint0.00.00.2-0.1-0.1-0.20.0-0.1-0.0-0.1-0.1-0.0-0.10.00.20.20.20.10.2-0.40.10.1-0.1-0.4
Sum of active levers in priming session hrs 5-60.00.00.20.20.20.10.10.00.10.1-0.0-0.0-0.1-0.30.00.20.20.20.0-0.40.20.2-0.2-0.5
Progressive ratio0.00.10.2-0.1-0.1-0.4-0.3-0.2-0.3-0.4-0.4-0.4-0.1-0.00.10.0-0.0-0.40.10.1-0.3-0.40.30.2
Food seeking constrained by brief footshock7.99.713.4-3.5-3.5-3.3-3.2-3.5-3.5-3.1-3.4-3.4-3.7-3.43.6-2.8-2.7-2.53.62.7-2.5-2.42.42.2
Seeking ratio, punishment vs. effort0.91.22.4-1.4-1.4-1.1-1.0-1.3-1.2-0.9-1.1-1.1-1.5-1.41.5-1.0-1.0-0.51.50.8-0.6-0.40.60.5
Retroperitoneal fat weight1.14.56.71.91.91.82.21.91.92.01.81.81.52.2-1.52.62.62.4-1.4-2.62.52.4-2.5-2.6
Reaction time number correct0.71.42.1-1.4-1.4-1.4-1.2-1.1-1.2-1.2-1.1-1.1-1.1-1.21.1-1.2-1.2-1.11.11.0-1.1-1.11.01.1
Reaction time mean minus median0.81.92.61.61.61.41.51.41.41.51.51.41.31.4-1.31.21.21.4-1.3-0.91.41.4-1.3-0.9
Reaction time mean minus median AUC0.51.31.51.21.21.01.21.11.11.21.11.11.01.2-1.01.21.21.2-1.0-0.91.21.2-1.2-0.9
Reaction time num false alarms0.20.20.6-0.8-0.8-0.7-0.3-0.5-0.6-0.5-0.5-0.5-0.7-0.30.70.20.2-0.00.8-0.40.2-0.0-0.2-0.4
Reaction time num false alarms AUC0.20.30.7-0.9-0.9-0.8-0.4-0.6-0.7-0.6-0.6-0.6-0.7-0.50.8-0.1-0.1-0.20.8-0.2-0.0-0.2-0.1-0.1
Reaction time trials correct on left0.71.42.1-1.4-1.4-1.4-1.2-1.1-1.2-1.2-1.1-1.1-1.1-1.21.1-1.2-1.2-1.11.11.0-1.1-1.11.01.1
Reaction time trials on left0.91.62.3-1.5-1.5-1.5-1.3-1.2-1.3-1.3-1.2-1.2-1.2-1.31.1-1.3-1.3-1.31.11.2-1.2-1.31.21.3
Reaction time mean0.10.10.6-0.1-0.1-0.2-0.2-0.3-0.2-0.2-0.3-0.4-0.3-0.50.3-0.6-0.6-0.10.30.7-0.1-0.10.10.8
Reaction time mean AUC0.10.10.7-0.1-0.1-0.2-0.2-0.2-0.2-0.2-0.2-0.3-0.2-0.40.2-0.7-0.7-0.20.20.8-0.2-0.10.20.8
Median of all reaction times0.50.81.6-0.7-0.7-0.8-0.8-0.8-0.8-0.8-0.8-0.9-0.8-1.00.8-1.2-1.2-0.70.81.2-0.6-0.60.61.3
Reaction time omissions1.11.73.5-0.9-0.9-1.0-1.3-1.1-1.0-1.2-1.0-1.0-0.8-1.10.8-1.7-1.7-1.50.71.8-1.5-1.51.51.9
Reaction time false alarm rate0.20.20.60.20.20.30.50.40.30.40.30.30.30.5-0.20.70.70.5-0.2-0.80.60.5-0.6-0.8
Reaction time premature initiation rate0.10.20.7-0.2-0.2-0.2-0.3-0.2-0.2-0.3-0.4-0.4-0.2-0.70.2-0.8-0.9-0.30.30.5-0.3-0.30.20.8
Reaction time premature initiations0.81.42.4-1.2-1.2-1.2-1.1-1.0-1.1-1.1-1.2-1.2-1.0-1.41.0-1.5-1.6-1.11.01.1-1.0-1.00.91.5
Std. dev. reaction times0.40.81.21.11.10.91.00.90.90.90.90.80.80.8-0.70.70.71.0-0.7-0.61.11.1-1.1-0.5
Reaction time trials completed0.91.62.3-1.5-1.5-1.5-1.3-1.2-1.3-1.3-1.2-1.2-1.2-1.31.1-1.3-1.3-1.31.11.2-1.2-1.31.21.3
Reaction time trials AUC0.81.42.1-1.4-1.4-1.5-1.2-1.2-1.2-1.2-1.2-1.1-1.1-1.31.1-1.2-1.2-1.21.11.1-1.1-1.21.11.2
Run reversals in cocaine runway, females0.10.10.7-0.1-0.1-0.1-0.2-0.1-0.1-0.2-0.2-0.20.0-0.40.0-0.7-0.7-0.40.00.6-0.4-0.40.40.8
Run reversals in cocaine runway, males0.50.50.80.60.60.60.80.70.70.80.70.60.60.4-0.60.70.70.8-0.6-0.70.80.9-0.8-0.7
Latency to leave start box in cocaine runway1.01.11.9-1.0-1.0-1.0-1.0-0.8-0.8-0.9-0.7-0.7-0.5-1.00.4-1.3-1.3-1.30.41.2-1.4-1.31.41.3
Latency to leave start box in cocaine runway, F0.50.61.0-0.7-0.7-0.7-0.8-0.6-0.6-0.7-0.6-0.6-0.4-0.60.4-0.9-1.0-1.00.30.7-1.0-1.01.00.9
Latency to leave start box in cocaine runway, M0.20.20.6-0.4-0.4-0.3-0.4-0.3-0.2-0.3-0.1-0.1-0.1-0.40.0-0.7-0.7-0.60.00.7-0.6-0.60.70.7
Std. dev. time between licks in bursts0.50.71.1-1.1-1.1-1.1-0.8-0.9-0.9-0.8-0.8-0.9-0.9-1.00.9-0.7-0.7-0.70.90.4-0.7-0.70.70.3
Total sessions with >9 infusions0.00.00.2-0.0-0.0-0.1-0.1-0.1-0.1-0.1-0.1-0.1-0.1-0.10.1-0.3-0.3-0.10.00.4-0.2-0.10.20.3
Short access day 1 total inactive lever presses0.20.20.60.50.50.40.50.30.40.40.20.20.10.2-0.00.40.40.7-0.0-0.30.70.8-0.8-0.5
Short access day 10 total inactive lever presses1.02.33.61.21.21.21.71.51.41.51.41.41.21.5-1.11.71.71.8-1.1-1.71.91.8-1.9-1.6
Short access day 1 total infusions0.40.50.70.80.80.70.80.70.80.80.70.70.70.8-0.70.60.70.8-0.7-0.50.70.7-0.7-0.6
Short access day 10 total infusions0.20.20.7-0.3-0.3-0.3-0.5-0.4-0.4-0.4-0.5-0.4-0.4-0.30.3-0.4-0.4-0.40.30.9-0.5-0.40.50.5
Short access total infusions0.10.10.4-0.3-0.3-0.3-0.4-0.4-0.4-0.3-0.4-0.4-0.4-0.30.4-0.3-0.3-0.20.40.6-0.3-0.20.30.3
Short access day 1 locomotion0.30.41.00.80.80.70.40.70.70.50.70.81.00.6-1.00.10.10.0-1.0-0.1-0.1-0.00.10.1
Short access day 10 total locomotion0.30.61.9-0.2-0.2-0.3-0.6-0.2-0.2-0.5-0.2-0.20.2-0.1-0.2-1.1-1.1-1.1-0.31.2-1.1-1.11.21.4
Short access total locomotion0.30.41.1-0.1-0.1-0.2-0.5-0.2-0.1-0.4-0.2-0.20.1-0.1-0.2-0.8-0.8-0.9-0.21.0-1.0-0.91.01.0
One hour access (0.3 mA shock)0.10.10.3-0.3-0.3-0.4-0.0-0.3-0.3-0.1-0.3-0.3-0.5-0.20.6-0.00.00.40.5-0.00.40.4-0.4-0.2
Compulsive drug intake0.20.30.90.40.40.50.40.20.20.30.30.30.00.30.00.70.70.60.0-0.90.70.6-0.7-0.8
One hour access (shock baseline)0.20.30.6-0.6-0.6-0.7-0.5-0.5-0.5-0.4-0.6-0.6-0.5-0.60.5-0.7-0.7-0.40.50.8-0.5-0.40.50.6
Social response proportion3.84.36.61.81.81.82.11.81.81.91.82.01.42.0-1.32.52.52.4-1.3-2.52.42.4-2.5-2.6
Social responses0.50.61.8-0.2-0.2-0.10.70.30.20.40.20.3-0.10.40.31.01.01.10.3-1.21.31.1-1.3-1.3
Social time0.10.20.50.30.30.20.40.30.20.20.20.30.10.4-0.10.70.70.5-0.0-0.70.60.5-0.6-0.7
Soleus weight2.26.68.3-2.5-2.5-2.5-2.7-2.5-2.5-2.6-2.4-2.4-2.2-2.42.1-2.8-2.8-2.82.12.9-2.8-2.82.82.7
Bone: stiffness0.71.11.3-1.1-1.1-1.1-1.1-1.1-1.1-1.1-1.1-1.1-1.1-1.01.1-0.9-0.9-1.01.10.9-1.0-1.00.90.9
Tibialis anterior weight6.220.930.5-5.3-5.3-5.3-4.7-5.2-5.2-4.9-5.2-5.1-5.5-5.05.5-3.5-3.5-3.65.53.0-3.4-3.53.22.5
Time to tail flick, vehicle, before self-admin0.10.10.30.60.60.40.20.30.30.20.40.30.40.4-0.40.20.2-0.0-0.4-0.1-0.1-0.10.1-0.1
Time to tail flick, vehicle, after self-admin0.40.61.3-0.6-0.6-0.6-0.8-0.7-0.6-0.7-0.6-0.6-0.4-0.40.4-0.7-0.7-1.00.31.1-1.1-1.11.20.9
Time to tail flick, test, before self-admin0.30.30.8-0.6-0.6-0.6-0.5-0.6-0.5-0.6-0.5-0.5-0.7-0.90.7-0.4-0.4-0.30.7-0.0-0.2-0.30.20.1
Time to tail flick, test, after self-admin1.71.82.4-1.5-1.5-1.4-1.3-1.3-1.3-1.4-1.2-1.2-1.2-1.31.2-1.5-1.5-1.31.21.3-1.2-1.31.21.4
Delta time to tail flick, vehicle, before/after SA0.30.30.6-0.6-0.6-0.5-0.6-0.5-0.4-0.5-0.4-0.4-0.3-0.20.3-0.3-0.3-0.70.30.6-0.7-0.70.80.4
Delta time to tail flick, test, before/after SA0.20.21.1-0.1-0.1-0.1-0.2-0.00.0-0.20.10.00.20.3-0.3-0.6-0.6-0.5-0.31.0-0.6-0.60.61.0
Tibia length1.43.94.4-2.1-2.1-2.1-2.1-2.1-2.1-2.0-2.1-2.0-2.0-2.02.0-1.9-1.9-1.91.91.9-1.9-1.91.91.8
Ambulatory time before self-admin0.10.20.40.40.40.50.50.50.50.40.40.50.40.2-0.40.10.00.5-0.3-0.30.60.6-0.60.0
Ambulatory time after self-admin0.10.10.20.20.20.30.30.20.30.30.30.30.10.1-0.1-0.0-0.00.4-0.10.00.40.4-0.40.0
Bone: tissue strength0.80.81.10.80.80.81.00.90.90.90.90.90.80.8-0.80.90.80.9-0.8-1.01.00.9-1.0-0.9
Total heroin consumption0.60.72.0-0.4-0.4-0.5-0.8-0.6-0.6-0.8-0.6-0.6-0.3-0.80.3-1.3-1.3-1.10.31.1-1.1-1.11.11.4
Bone: trabecular number0.30.51.3-0.4-0.4-0.4-0.7-0.5-0.5-0.6-0.6-0.6-0.3-0.70.3-1.1-1.1-0.90.31.0-0.9-0.90.91.1
Bone: trabecular spacing0.40.61.8-0.8-0.8-0.9-0.4-0.8-0.9-0.6-0.8-0.8-1.2-0.81.30.20.30.21.3-0.50.40.3-0.5-0.7
Bone: trabecular thickness0.60.72.6-0.2-0.2-0.2-0.6-0.3-0.2-0.5-0.2-0.20.1-0.3-0.2-1.3-1.3-1.1-0.21.4-1.2-1.11.21.6
Bone: trabecular tissue density4.36.49.72.12.12.12.72.42.22.52.32.31.92.4-1.72.92.93.0-1.7-3.03.13.0-3.1-3.0
Water consumed over 24 hours1.82.43.2-1.6-1.6-1.6-1.7-1.6-1.5-1.6-1.5-1.5-1.3-1.31.3-1.4-1.4-1.81.31.6-1.8-1.81.81.4
Number of responses in last shaping day2.32.63.3-1.5-1.5-1.6-1.8-1.8-1.8-1.8-1.7-1.7-1.7-1.81.7-1.4-1.4-1.61.71.2-1.5-1.61.51.1