Scara5

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	Scara5	0.03	0.02	1.8e-03	0.01	0.01	0.01	0	1.4e-02	6.8e-03	2.6e-03	6.2e-02
2	Liver	gene expression	Scara5	0.03	0.02	6.3e-04	0.03	0.02	0.03	0.02	8.5e-04	1.7e-03	3.9e-04	1.9e-03
3	Brain	gene expression	Scara5	0.12	0.06	1.1e-11	0.14	0.13	0.12	0.13	1.1e-12	6.3e-12	3.3e-11	2.6e-12
4	Adipose	gene expression	Scara5	0.52	0.13	0.0e+00	0.49	0.58	0.57	0.58	4.0e-61	9.1e-79	1.2e-77	4.0e-78
5	LHb	mRNA stability	Scara5	0.16	0.11	8.9e-03	0.03	0.02	-0.01	0.01	7.9e-02	8.7e-02	7.4e-01	1.7e-01
6	Adipose	mRNA stability	Scara5	0.03	0.03	1.4e-03	0.03	0.02	0.04	0.03	2.7e-04	1.6e-03	2.4e-05	3.5e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	1.0	1.9	2.7	-1.5	-1.6	-1.6	1.6	1.2	-0.3
Area under the delay curve	1.0	1.5	5.0	2.2	0.4	0.4	-0.6	-1.4	-1.3
BMI with tail	0.2	0.8	1.2	1.1	0.9	0.9	-0.8	-0.5	-1.1
BMI without tail	0.1	0.6	1.4	0.0	1.2	1.2	-0.8	-0.4	-0.4
Body weight	0.2	1.1	3.3	1.8	0.7	0.3	-0.7	-1.3	-0.4
Weight adjusted by age	0.2	0.7	2.0	1.4	0.3	-0.2	-0.4	-1.4	0.4
Bone surface	0.8	1.7	2.9	-1.3	-1.6	-1.7	1.5	0.8	0.3
Bone volume	0.8	1.5	2.8	-1.1	-1.6	-1.7	1.5	0.6	-0.1
Breakpoint value in progressive ratio session	0.2	0.3	0.8	0.9	-0.1	-0.2	0.0	-0.6	-0.9
Number of licking bursts	0.1	0.2	1.1	0.3	0.1	0.4	-0.0	0.1	-1.0
Context. condit. distance diff. score	0.9	1.1	2.0	-1.4	0.8	1.3	-0.3	1.3	-0.6
Locomotion velocity, session 1	0.4	0.5	1.2	0.1	-0.8	-1.1	0.8	-0.1	-0.5
Locomotion distance, session 1	1.0	1.3	3.8	-0.1	-1.5	-1.9	1.3	-0.0	0.1
Locomotion velocity, session 2	0.4	0.5	1.6	0.3	-1.0	-1.3	0.7	0.2	-0.1
Locomotion distance, session 2	1.5	2.1	6.0	-0.3	-1.9	-2.5	1.6	0.3	0.3
Locomotion velocity, session 3	1.4	1.6	2.9	1.2	1.7	1.4	-1.4	-1.0	-0.3
Locomotion distance, session 3	0.5	0.5	0.8	0.7	0.9	0.9	-0.7	-0.5	-0.7
Stereotopy head waving bouts, day 3	0.1	0.1	0.3	0.0	0.0	-0.1	-0.0	-0.3	0.5
Stereotopy head waving duration, day 3	0.8	1.0	1.7	1.3	1.0	0.7	-1.0	-1.3	0.3
Locomotion velocity, session 7	1.1	1.2	2.4	-1.5	0.2	1.1	0.2	1.6	-1.1
Locomotion distance, session 7	1.7	2.2	5.0	-2.2	-0.8	0.1	1.1	2.2	-1.2
Stereotopy head waving bouts, day 7	0.7	0.8	2.1	1.5	0.6	0.3	-0.7	-1.3	0.2
Stereotopy head waving duration, day 7	1.8	2.2	4.5	2.1	1.4	1.0	-1.4	-1.9	0.0
Locomotion velocity, session 8	0.2	0.2	0.5	0.1	0.7	0.6	-0.6	-0.3	0.0
Locomotion distance, session 8	0.3	0.5	1.0	-1.0	-0.6	-0.6	0.7	0.8	-0.4
Degree of sensitization distance	3.3	3.6	8.6	-2.9	-1.6	-0.7	1.6	2.6	-0.3
Degree of sensitization stereotypy	1.0	1.1	2.4	1.6	1.0	0.7	-1.1	-1.3	-0.1
Conditioned locomotion	0.1	0.2	0.5	-0.7	-0.0	0.2	0.2	0.4	-0.5
Cocaine response after cond. corrected	0.5	0.7	1.8	0.0	1.1	1.3	-0.8	0.2	-0.8
Cocaine response after cond. not corrected	0.3	0.4	0.8	-0.0	0.6	0.8	-0.4	0.5	-0.9
Cocaine response before conditioning	0.9	1.1	2.7	-0.0	-1.4	-1.6	1.2	0.5	-0.1
Saline control response	0.4	0.5	1.4	-0.0	-1.0	-1.2	0.7	-0.2	0.6
Bone: connectivity density	2.6	4.1	6.1	-2.5	-2.0	-1.9	2.3	2.3	-0.3
Bone: cortical apparent density	0.5	0.8	2.0	0.5	1.2	1.4	-1.0	-0.3	-0.5
Bone: cortical area	0.3	0.5	1.7	1.0	-0.1	-0.3	-0.3	-1.3	-0.0
Bone: cortical porosity	0.4	0.4	1.7	1.3	0.2	-0.1	-0.4	-0.8	-0.1
Bone: cortical porosity	0.5	0.5	1.8	1.4	0.2	-0.2	-0.4	-1.1	0.2
Bone: cortical thickness	0.5	0.8	2.0	1.3	0.5	0.4	-0.8	-1.4	-0.2
Bone: cortical thickness	0.6	0.7	1.1	0.9	1.0	1.0	-1.0	-0.3	-0.6
Bone: cortical tissue density	0.6	1.0	2.3	0.4	1.3	1.5	-1.1	-0.2	-0.5
Condit. Reinf. active minus inactive responses	0.2	0.2	0.5	0.5	-0.2	-0.4	0.1	-0.7	0.4
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.3	0.3	0.6	0.5	-0.5	-0.5	0.4
Condit. Reinf. active responses	0.5	0.6	1.6	0.3	-1.1	-1.3	0.8	-0.5	0.1
Condit. Reinf. inactive responses	1.7	2.3	5.3	-0.4	-2.1	-2.3	1.8	0.5	-0.2
Incentive salience index mean	0.4	0.5	1.1	1.0	-0.3	-0.6	0.1	-1.0	0.6
Condit. Reinf. lever presses	0.4	0.6	1.3	0.9	-0.7	-1.1	0.4	-0.7	0.7
Condit. Reinf. active minus inactive responses	0.3	0.5	1.0	-0.5	-1.0	-1.0	0.8	0.2	0.1
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	-0.0	0.4	0.4	-0.3	-0.5	0.5
Condit. Reinf. active responses	0.6	0.8	1.6	-0.6	-1.3	-1.2	1.1	0.5	-0.4
Condit. Reinf. inactive responses	1.6	2.3	3.6	-1.4	-1.9	-1.7	1.7	1.5	-0.6
Condit. Reinf. lever presses	0.2	0.2	0.7	0.1	-0.5	-0.8	0.4	-0.1	0.4
Condit. Reinf. lever reinforcers received	0.4	0.5	1.0	-0.3	-1.0	-1.0	0.8	0.2	-0.4
Conditioned reinforcement - actives	0.3	1.3	5.0	-2.2	-0.5	-0.2	0.6	1.3	0.9
Conditioned reinforcement - inactives	0.9	2.5	4.9	-2.0	-1.5	-1.1	1.5	2.2	0.8
Conditioned locomotion	0.3	0.4	0.8	-0.7	0.7	0.9	-0.7	0.4	0.6
Patch foraging indifference point 0 sec	1.4	3.9	9.4	-0.3	-2.8	-3.1	2.4	0.6	-0.1
Patch foraging indifference point AUC	1.0	2.3	5.1	0.2	2.0	2.3	-1.9	-1.1	0.0
Delay disc. indifference point, 0s delay	1.3	1.4	3.1	-0.3	-1.8	-1.7	1.4	0.7	0.1
Delay disc. indifference point, 16s delay	0.7	0.9	2.1	1.4	0.5	0.6	-0.6	-0.9	-1.3
Delay disc. indifference point, 2s delay	0.5	0.6	1.0	0.5	-0.9	-1.0	0.5	-0.9	0.5
Delay disc. indifference point, 24s delay	0.5	0.8	2.0	1.4	0.7	0.7	-0.8	-0.7	-1.0
Delay disc. indifference point, 4s delay	1.8	2.0	4.6	2.1	1.2	1.2	-1.3	-1.6	-0.4
Delay disc. indifference point, 8s delay	1.3	2.2	6.4	2.5	0.7	0.7	-0.8	-1.3	-1.8
Indifference point function ln k	0.3	0.9	2.5	0.4	-1.2	-1.6	1.2	0.2	-0.2
Indifference point function log k	0.3	0.9	2.5	0.4	-1.2	-1.6	1.2	0.2	-0.2
Patch foraging total patch changes 0 sec	1.0	3.1	7.8	0.1	-2.5	-2.8	2.1	0.2	-0.0
Patch foraging total patch changes 12 sec	0.2	0.3	0.8	0.0	-0.9	-0.8	0.6	-0.2	-0.3
Patch foraging total patch changes 18 sec	0.0	0.1	0.2	-0.5	-0.4	-0.3	0.2	0.1	-0.0
Patch foraging total patch changes 24 sec	0.1	0.5	1.0	0.4	-0.8	-1.0	0.4	-1.0	0.2
Patch foraging total patch changes 6 sec	0.1	0.1	0.3	0.1	-0.5	-0.4	0.4	-0.1	-0.5
Patch foraging time to switch 0 sec	0.3	1.3	2.0	-0.8	-1.4	-1.1	1.3	1.4	-0.7
Patch foraging water rate 0 sec	0.1	0.5	1.5	1.0	0.5	-0.0	-0.5	-1.2	0.3
Patch foraging water rate 12 sec	0.1	0.4	1.3	0.5	0.1	-0.4	-0.2	-0.6	1.1
Patch foraging water rate 18 sec	2.1	4.8	8.1	2.9	2.4	1.8	-2.3	-2.5	0.1
Patch foraging water rate 24 sec	0.6	0.8	1.6	0.4	1.3	1.1	-1.0	-0.7	0.7
Patch foraging water rate 6 sec	1.0	1.5	2.4	1.4	1.1	0.4	-1.1	-1.5	1.3
Seeking ratio, delayed vs. immediate footshock	1.4	2.0	3.4	-0.9	-1.8	-1.9	1.6	1.4	0.6
Distance traveled before self-admin	0.3	0.6	1.6	0.5	0.6	0.3	-0.7	-0.8	1.3
Distance traveled after self-admin	0.6	1.1	1.8	1.1	1.1	0.6	-1.1	-1.3	0.8
Extensor digitorum longus weight	7.1	28.3	45.0	6.7	5.6	4.6	-5.6	-6.4	-0.2
Bone: elastic displacement	0.8	1.0	2.0	-0.6	-1.3	-1.4	1.0	0.6	0.7
Bone: elastic work	0.9	1.1	3.4	0.5	-1.3	-1.8	1.0	-0.4	0.4
Bone: endosteal estimation	0.1	0.2	0.6	-0.3	-0.7	-0.8	0.5	-0.0	0.2
Bone: endosteal perimeter	0.5	1.2	2.8	-0.8	-1.5	-1.7	1.2	0.4	0.6
Epididymis fat weight	0.1	0.7	1.6	0.1	-0.9	-0.8	0.8	0.6	-1.3
Delta time in closed arm before/after self-admin	1.3	1.3	1.9	-1.3	-1.2	-1.0	1.3	1.4	-0.1
Delta time in open arm before/after self-admin	0.2	0.2	0.6	0.6	0.3	0.3	-0.4	-0.7	-0.4
Diff in mean of infusions in LGA sessions	0.8	1.4	4.5	2.1	-0.2	-0.5	0.1	-1.4	-1.4
Delay discount exponential model param	1.7	2.3	6.7	-2.6	-0.8	-0.8	1.1	1.7	1.2
Extinction: sum of active levers before priming	0.3	0.4	0.7	-0.1	-0.8	-0.8	0.8	0.1	-0.6
Active lever presses in extinction session 6	0.2	0.2	0.5	-0.6	0.5	0.7	-0.4	0.3	0.2
Bone: final force	0.3	0.5	1.9	0.9	0.0	-0.1	-0.3	-1.4	-0.0
Bone: final moment	0.3	0.5	2.1	0.9	-0.2	-0.4	-0.1	-1.4	0.1
Food consumed during 24 hour testing period	0.2	0.4	1.0	0.4	0.4	0.1	-0.5	-0.7	1.0
Glucose	1.0	1.6	2.9	0.9	1.6	1.7	-1.6	-0.8	-0.3
Heart weight	0.3	0.4	0.8	-0.3	-0.9	-0.7	0.8	0.2	-0.7
Delay discount hyperbolic model param	1.4	1.8	5.6	-2.4	-0.7	-0.6	0.9	1.7	0.9
Intermittent access intake day 1-15 change	0.1	0.7	1.7	-1.3	-0.8	-0.4	0.8	1.1	0.4
Intermittent access intake escalation	0.1	0.4	0.9	-0.9	-0.7	-0.2	0.7	0.8	0.0
Intermittent access intake escalation 2	0.0	0.1	0.2	-0.4	-0.2	0.1	0.2	0.4	0.0
Intermitt. access day 1 inactive lever presses	0.1	1.4	3.1	-1.7	-1.0	-0.4	1.1	1.8	0.4
Intermitt. access day 15 inactive lever presses	0.1	0.5	1.1	-0.2	1.0	1.1	-0.7	-0.1	0.6
Intermitt. access escalation Index	0.2	0.5	1.1	-0.4	-1.0	-1.1	0.9	0.5	-0.1
Intermittent access day 1 total infusions	0.1	0.4	1.5	-0.5	0.6	0.4	-0.6	-0.0	1.2
Intermittent access day 15 total infusions	0.2	0.6	2.0	-1.4	-0.2	0.1	0.2	0.9	0.8
Intermittent access terminal intake (last 3 days)	0.4	0.8	1.2	-1.1	0.8	1.0	-0.7	0.4	1.1
Intermittent access total infusions	0.7	0.8	3.0	-1.7	0.1	0.3	-0.0	0.9	1.0
Intermittent access day 1 locomotion	0.1	0.2	0.5	0.1	-0.6	-0.7	0.5	0.2	-0.2
Intermittent access day 15 total locomotion	0.2	0.7	1.5	-0.4	1.0	1.2	-0.9	-0.3	1.0
Intermittent access total locomotion	0.1	0.1	0.3	-0.3	0.1	0.2	-0.1	0.1	0.5
Intermittent access standard deviation	0.5	2.4	5.1	-0.2	1.7	1.6	-1.7	-1.1	2.3
Left kidney weight	0.1	0.8	2.4	1.5	0.3	0.1	-0.5	-1.5	-0.1
Right kidney weight	0.1	0.7	1.4	1.2	-0.9	-1.2	0.6	-0.6	-0.3
Cocaine induced anxiety	0.3	0.7	1.4	1.1	-0.9	-1.2	0.6	-0.7	-0.4
Post-drug Anxiety	2.8	3.2	6.3	0.6	-2.3	-2.5	2.1	-0.2	-1.8
Baseline Anxiety	0.5	0.8	2.4	-0.2	-0.8	-0.7	0.9	0.4	-1.6
Tail length	0.1	0.7	1.5	-0.7	-1.1	-1.2	1.0	0.1	0.5
Length with tail	0.2	1.0	2.8	0.4	-1.3	-1.7	1.0	-0.2	0.2
Length without tail	0.2	1.2	5.2	2.3	0.2	-0.2	-0.7	-1.3	0.0
Times rat made contact with spout	0.0	0.1	0.2	-0.1	0.3	0.4	-0.2	-0.1	0.0
Lifetime Intake	0.6	0.8	2.4	-1.5	0.3	0.4	-0.2	0.6	1.2
Liver weight, left	0.5	0.8	2.5	1.6	0.6	0.1	-0.7	-0.9	0.9
Liver weight, right	2.1	3.6	5.0	2.2	2.1	1.9	-2.1	-2.1	-0.3
Locomotor activity	0.9	1.5	2.9	1.7	-0.9	-1.5	0.4	-1.6	0.4
Locomotor testing distance	2.1	5.1	12.8	-0.6	-3.1	-3.6	2.7	0.7	0.4
Locomotor testing rearing	2.1	7.6	17.2	-1.2	-3.7	-4.2	3.2	1.2	1.2
Locomotion in novel chamber	0.2	0.2	0.9	0.6	-0.0	-0.1	0.2	-0.4	-0.9
Locomotion in novel chamber post-restriction	0.2	0.6	0.9	0.6	1.0	0.7	-1.0	-0.9	-0.0
Fecal boli incidents, locomotor time 1	0.8	2.1	3.3	1.2	1.6	1.4	-1.8	-1.6	0.8
Change in fecal boli incidents, locomotor task	0.2	0.2	0.6	-0.4	-0.3	-0.1	0.6	0.8	-0.5
Time >=10cm from walls, locomotor time 1	0.6	0.7	1.4	-0.3	-1.2	-1.0	1.1	0.2	-0.8
Bouts of movement, locomotor time 1	0.4	0.5	0.9	0.2	0.9	0.9	-0.9	-0.5	0.6
Total resting periods, locomotor time 1	0.8	0.9	1.9	0.1	1.3	1.4	-1.2	-0.5	0.7
Rest time, locomotor task time 1	0.5	0.8	1.6	-0.0	1.2	1.3	-1.0	0.4	0.5
Distance moved, locomotor task time 1	0.3	0.9	1.7	-0.4	-1.3	-1.2	1.2	0.3	-0.9
Vertical activity count, locomotor time 1	0.1	0.6	1.5	0.4	-0.7	-1.0	0.5	-1.2	0.4
Time >=10cm from walls, locomotor time 2	0.1	0.2	0.8	-0.2	0.3	0.3	-0.3	0.0	0.9
Bouts of movement, locomotor time 2	0.5	1.7	2.6	1.6	1.6	1.3	-1.4	-1.0	-0.4
Total resting periods, locomotor time 2	0.7	2.9	4.7	1.9	2.2	1.9	-1.9	-1.3	-0.3
Rest time, locomotor task time 2	4.1	6.9	12.0	2.0	3.5	3.4	-3.2	-1.7	0.1
Distance moved, locomotor task time 2	2.1	2.9	5.3	-1.2	-2.3	-2.3	2.1	1.0	-0.0
Vertical activity count, locomotor time 2	0.5	1.2	3.3	-0.4	-1.4	-1.8	1.1	0.2	0.9
Light reinforcement 1	0.1	0.4	0.6	-0.6	-0.8	-0.5	0.7	0.7	-0.7
Light reinforcement 2	0.3	0.6	1.7	-0.5	1.0	1.3	-0.8	0.4	-0.2
Bone: marrow area	0.1	0.3	0.7	-0.3	-0.7	-0.9	0.6	0.0	0.2
Bone: maximum diameter	0.3	0.7	1.6	1.1	0.6	0.4	-0.8	-1.3	0.1
Bone: maximum force	0.4	0.9	2.7	1.5	0.2	-0.2	-0.6	-1.7	-0.0
Bone: maximum moment	0.5	0.9	2.8	1.4	-0.1	-0.5	-0.3	-1.7	0.1
Mean time between licks in bursts	0.7	4.2	6.0	-2.3	-2.3	-2.0	2.5	2.1	-0.3
Mean num. licks in bursts	0.1	0.2	1.0	-0.4	0.1	0.0	-0.2	-0.1	1.0
Cd content in liver	0.4	0.4	1.0	1.0	0.3	-0.2	-0.5	-1.0	0.5
Co content in liver	2.3	2.7	3.9	1.5	2.0	1.8	-2.0	-1.6	0.0
Cu content in liver	0.8	0.9	1.4	1.2	1.1	1.0	-1.1	-0.7	-0.4
Fe content in liver	1.8	2.2	4.2	-1.4	-1.6	-1.3	1.7	2.0	-0.4
K content in liver	0.6	0.5	1.0	-1.0	-0.5	-0.3	0.8	1.0	-0.6
Mg content in liver	0.8	0.9	1.5	-1.2	-0.9	-0.8	1.1	1.1	-0.1
Mn content in liver	1.4	1.6	2.3	-1.4	-1.5	-1.3	1.5	1.2	-0.1
Na content in liver	1.6	1.8	6.0	2.4	0.5	-0.0	-0.7	-2.0	0.1
Rb content in liver	0.1	0.1	0.4	-0.6	0.1	0.0	0.2	0.6	0.1
Se content in liver	3.2	3.7	7.3	-0.9	-2.6	-2.7	2.3	1.5	0.3
Sr content in liver	0.9	0.7	0.9	-1.0	-1.0	-0.9	1.0	0.8	0.4
Zn content in liver	0.8	0.9	1.5	-0.9	-1.0	-1.2	1.0	0.8	0.5
Bone: minimum diameter	0.2	0.4	1.2	0.8	-0.2	-0.5	-0.2	-1.1	0.6
Time in familiar zone, hab. session 1	0.2	0.2	0.5	-0.7	-0.4	-0.3	0.3	0.4	0.2
Time in novel zone, hab. session 1	2.0	2.3	3.2	1.8	1.8	1.7	-1.6	-1.2	-0.6
Total zone transitions, hab. session 1	0.2	0.2	0.6	0.7	-0.3	-0.6	0.0	-0.8	-0.1
Total locomotion distance, hab. session 1	0.5	0.7	2.1	-0.0	-1.2	-1.4	0.9	0.2	-0.1
Locomotion velocity, hab. session 1	1.3	1.8	5.0	-0.3	-1.9	-2.2	1.5	0.4	0.1
Time in familiar zone, hab. session 2	0.2	0.2	0.7	-0.4	0.6	0.9	-0.4	0.1	-0.2
Time in novel zone, hab. session 2	0.1	0.1	0.5	0.3	-0.4	-0.7	0.3	-0.1	0.2
Total zone transitions, hab. session 2	0.3	0.4	0.8	0.9	-0.0	-0.6	-0.1	-0.9	0.6
Total locomotion distance, hab. session 2	0.2	0.2	0.9	0.2	-0.5	-0.9	0.3	-0.2	0.4
Locomotion velocity, hab. session 2	0.2	0.3	0.8	0.5	-0.4	-0.9	0.2	-0.5	0.5
Novel to familiar place preference ratio	0.3	0.4	0.6	-0.6	-0.8	-0.8	0.5	0.5	0.6
Novelty place preference	0.4	0.5	0.9	-0.6	-0.9	-0.9	0.6	0.6	0.5
Time in novel zone, NPP test	0.4	0.4	0.9	-0.5	-0.9	-0.9	0.6	0.4	0.5
Total zone transitions, NPP test	0.9	1.3	3.4	-0.2	-1.5	-1.8	1.4	0.2	-0.2
Total locomotion distance, NPP test	4.1	5.7	9.8	-1.9	-3.0	-3.1	2.8	1.8	-0.0
Locomotion velocity, NPP test	3.3	4.7	7.6	-1.9	-2.7	-2.8	2.5	1.8	0.1
Intraocular pressure	1.3	2.1	3.0	-1.7	-1.7	-1.6	1.7	1.1	0.5
Delta distance traveled before/after self-admin	0.5	0.6	0.8	0.9	0.8	0.7	-0.8	-0.9	-0.2
Delta ambulatory time before/after self-admin	0.3	0.5	0.7	0.8	0.8	0.7	-0.8	-0.8	0.1
Parametrial fat weight	1.8	4.3	6.2	-2.3	-2.5	-2.1	2.3	2.0	-0.6
Pavlov. Cond. lever latency	0.2	0.3	0.6	-0.8	0.0	0.3	0.2	0.7	-0.6
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	0.3	0.1	-0.1	-0.0	0.0	0.1
Pavlov. Cond. change in total contacts	1.1	1.2	3.1	1.8	0.7	0.1	-1.0	-1.5	0.6
Pavlov. Cond. index score	0.4	0.5	2.1	1.4	0.4	0.0	-0.5	-0.8	0.1
Pavlov. Cond. latency score	0.3	0.3	1.3	1.2	0.2	-0.2	-0.3	-0.7	0.3
Pavlov. Cond. lever contacts	0.2	0.2	0.7	0.8	0.0	-0.2	-0.1	-0.5	0.5
Pavlov. Cond. magazine entry number	0.6	0.8	2.1	-1.4	-0.8	-0.5	0.8	0.9	-0.0
Pavlov. Cond. intertrial magazine entries	0.6	0.7	1.7	-0.1	-1.3	-1.3	1.1	-0.2	-0.0
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.7	2.6	1.6	0.6	0.2	-0.6	-1.0	0.1
Pavlov. Cond. response bias	0.6	0.7	1.9	1.4	0.8	0.6	-0.8	-0.9	0.1
Pavlov. Cond. lever latency	0.5	0.6	2.0	-1.4	-0.6	-0.1	0.7	1.0	-0.4
Pavlov. Cond. magazine entry latency	0.2	0.3	1.4	1.2	0.0	-0.1	-0.2	-0.5	-0.4
Pavlov. Cond. change in total contacts	1.0	2.4	5.7	2.4	1.4	0.8	-1.4	-2.0	0.2
Pavlov. Cond. index score	0.5	0.8	2.8	1.7	0.6	0.1	-0.7	-1.0	0.1
Pavlov. Cond. latency score	0.4	0.6	2.4	1.5	0.3	-0.1	-0.4	-0.9	-0.0
Pavlov. Cond. lever contacts	0.4	0.6	1.9	1.4	0.6	0.0	-0.7	-0.9	0.4
Pavlov. Cond. magazine entry number	0.1	0.1	0.5	-0.7	0.3	0.5	-0.1	0.1	0.3
Pavlov. Cond. intertrial magazine entries	4.0	8.7	14.0	-3.7	-3.3	-2.8	3.2	3.0	0.4
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.9	3.0	1.7	0.7	0.3	-0.8	-1.1	0.0
Pavlov. Cond. response bias	0.5	0.7	2.6	1.6	0.5	-0.0	-0.7	-0.9	0.2
Time in closed arm before self-admin	0.3	0.6	1.2	1.1	0.6	0.5	-0.5	-1.1	-0.5
Time in closed arm after self-admin	0.3	0.4	0.8	-0.5	-0.8	-0.7	0.9	0.3	0.1
Time in open arm before self-admin	0.7	0.9	1.1	-1.0	-1.0	-1.1	1.0	0.8	0.7
Time in open arm after self-admin	0.0	0.0	0.1	-0.0	-0.1	-0.2	0.1	0.0	-0.4
Bone: periosteal estimation	0.1	0.2	0.6	0.3	-0.4	-0.6	0.1	-0.8	0.1
Bone: periosteal perimeter	0.3	0.5	1.4	-0.1	-1.0	-1.2	0.7	-0.2	0.3
Bone: post-yield work	0.9	1.5	2.8	0.6	1.5	1.7	-1.6	-0.8	-0.6
Progressive ratio test 1 active lever presses	0.6	1.0	1.6	-0.5	1.3	1.3	-1.2	-0.2	1.0
Progressive ratio test 1 breakpoint	0.6	1.0	1.8	-0.4	1.3	1.3	-1.2	-0.3	1.1
Progressive ratio test 1 inactive lever presses	0.3	0.8	1.8	-1.3	-0.8	-0.7	1.0	1.0	0.2
Progressive ratio test 2 active lever presses	0.9	1.2	3.0	-0.5	1.2	1.2	-1.1	-0.4	1.7
Progressive ratio test 2 breakpoint	0.9	1.1	2.8	-0.3	1.2	1.1	-1.1	-0.5	1.7
Progressive ratio test 2 inactive lever presses	0.3	0.9	2.5	-1.5	0.4	0.6	-0.2	0.6	1.6
Incentive Sensitization - Responses	0.3	0.7	3.4	-0.1	0.5	0.3	-0.5	-0.5	1.8
Incentive Sensitization - Breakpoint	0.3	0.6	3.2	-0.1	0.4	0.2	-0.4	-0.5	1.8
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.5	-0.4	-0.1	0.2	0.3	0.7	-0.7
Progressive ratio	0.3	1.0	1.7	1.3	1.1	0.9	-1.0	-1.0	0.2
Food seeking constrained by brief footshock	1.0	1.3	2.9	-0.3	1.7	1.7	-1.2	0.7	0.4
Seeking ratio, punishment vs. effort	0.1	0.2	0.5	-0.7	0.4	0.5	-0.2	0.7	0.1
Retroperitoneal fat weight	0.4	1.6	2.1	-1.2	-1.5	-1.3	1.4	1.4	-0.6
Reaction time number correct	0.0	0.1	0.2	-0.4	0.3	0.1	-0.0	0.5	0.3
Reaction time mean minus median	0.0	0.2	0.5	0.7	-0.4	-0.5	0.3	-0.1	-0.7
Reaction time mean minus median AUC	0.0	0.1	0.2	0.3	-0.3	-0.4	0.3	0.4	-0.4
Reaction time num false alarms	0.3	0.5	0.8	0.8	-0.7	-0.9	0.6	-0.2	-0.9
Reaction time num false alarms AUC	0.2	0.4	1.1	1.0	-0.2	-0.4	0.1	-0.7	-0.6
Reaction time trials correct on left	0.0	0.1	0.2	-0.4	0.3	0.1	-0.0	0.5	0.3
Reaction time trials on left	0.0	0.1	0.3	-0.5	0.2	0.1	0.0	0.6	0.3
Reaction time mean	0.0	0.1	0.3	0.1	0.3	0.3	-0.2	-0.6	0.0
Reaction time mean AUC	0.1	0.1	0.5	0.3	0.2	0.2	-0.2	-0.7	0.1
Median of all reaction times	0.2	0.3	0.5	-0.0	0.5	0.6	-0.5	-0.7	0.4
Reaction time omissions	1.2	1.9	3.0	-1.7	-1.4	-1.4	1.6	1.5	0.1
Reaction time false alarm rate	0.3	0.4	1.0	1.0	-0.3	-0.3	0.1	-0.7	-0.8
Reaction time premature initiation rate	0.4	0.6	0.8	0.9	0.9	0.7	-0.9	-0.7	-0.2
Reaction time premature initiations	0.2	0.5	1.1	0.5	1.0	0.8	-0.9	-0.4	0.0
Std. dev. reaction times	0.0	0.0	0.1	0.2	0.1	0.0	-0.1	-0.1	-0.3
Reaction time trials completed	0.0	0.1	0.3	-0.5	0.2	0.1	0.0	0.6	0.3
Reaction time trials AUC	0.0	0.1	0.3	-0.6	0.2	0.1	0.1	0.6	0.4
Run reversals in cocaine runway, females	0.2	0.2	0.8	-0.9	-0.4	-0.3	0.4	0.4	0.2
Run reversals in cocaine runway, males	5.2	5.7	8.0	2.7	2.6	2.1	-2.8	-2.8	0.3
Latency to leave start box in cocaine runway	1.0	1.4	5.5	-0.9	0.9	0.7	-0.9	-0.2	2.4
Latency to leave start box in cocaine runway, F	1.6	2.0	4.1	0.1	1.6	1.4	-1.6	-0.9	2.0
Latency to leave start box in cocaine runway, M	0.8	0.7	2.0	-1.2	-0.3	-0.6	0.5	0.6	1.4
Std. dev. time between licks in bursts	3.5	6.6	11.6	-2.0	-3.4	-3.4	3.2	1.6	0.1
Total sessions with >9 infusions	0.2	0.2	0.6	-0.8	0.3	0.3	-0.2	0.3	0.6
Short access day 1 total inactive lever presses	1.2	2.4	3.7	0.5	1.9	1.9	-1.9	-1.5	0.9
Short access day 10 total inactive lever presses	0.0	0.1	0.4	-0.6	-0.3	-0.1	0.3	0.2	0.2
Short access day 1 total infusions	0.5	1.0	1.8	-1.2	1.0	1.1	-0.9	-0.1	1.3
Short access day 10 total infusions	0.4	0.7	2.6	-0.1	0.7	0.4	-0.9	-0.2	1.6
Short access total infusions	0.5	0.8	2.4	-0.5	0.8	0.7	-0.8	-0.3	1.6
Short access day 1 locomotion	0.3	0.5	1.4	0.3	0.6	0.3	-0.7	-0.6	1.2
Short access day 10 total locomotion	0.0	0.1	0.1	0.3	-0.3	-0.3	0.3	0.0	-0.1
Short access total locomotion	0.1	0.1	0.4	0.5	0.2	-0.1	-0.2	-0.6	0.4
One hour access (0.3 mA shock)	0.2	0.2	0.5	-0.7	0.0	0.1	-0.1	0.4	0.7
Compulsive drug intake	1.3	1.9	2.7	-0.6	-1.6	-1.6	1.6	1.3	-1.1
One hour access (shock baseline)	0.2	0.6	1.6	-0.8	0.6	0.7	-0.6	-0.2	1.3
Social response proportion	0.6	0.7	2.0	-1.4	0.3	0.4	0.1	1.4	0.4
Social responses	3.7	4.9	6.9	-2.6	-2.3	-2.1	2.4	2.6	0.2
Social time	0.5	0.8	1.7	-0.5	-1.3	-1.2	1.1	0.6	0.2
Soleus weight	0.6	1.7	2.6	1.6	1.5	1.4	-1.4	-1.1	-0.6
Bone: stiffness	0.5	0.9	1.8	1.4	0.7	0.6	-0.9	-1.3	-0.4
Tibialis anterior weight	5.3	18.2	33.5	5.8	4.2	3.2	-4.3	-5.4	-0.6
Time to tail flick, vehicle, before self-admin	0.2	0.3	1.2	0.5	-0.3	-0.3	0.3	-0.0	-1.1
Time to tail flick, vehicle, after self-admin	1.1	2.3	3.8	1.2	1.8	2.0	-1.6	-1.6	-0.3
Time to tail flick, test, before self-admin	1.6	1.8	3.2	-0.4	-1.6	-1.5	1.6	0.5	-1.8
Time to tail flick, test, after self-admin	2.2	2.3	6.0	-2.5	-1.2	-0.8	1.6	1.6	-0.7
Delta time to tail flick, vehicle, before/after SA	1.0	1.1	2.6	-0.2	1.4	1.6	-1.1	-0.8	0.3
Delta time to tail flick, test, before/after SA	0.9	1.1	3.3	-1.8	0.4	0.8	-0.0	1.3	0.7
Tibia length	1.1	3.1	7.7	-0.2	-2.5	-2.8	2.1	0.3	0.4
Ambulatory time before self-admin	0.1	0.5	0.8	0.5	0.6	0.3	-0.7	-0.8	0.9
Ambulatory time after self-admin	1.5	2.4	4.0	1.8	1.6	1.1	-1.7	-2.0	0.9
Bone: tissue strength	0.1	0.1	0.3	0.0	-0.5	-0.5	0.3	-0.3	-0.2
Total heroin consumption	2.0	2.3	3.4	1.5	1.6	1.5	-1.9	-1.7	0.9
Bone: trabecular number	1.5	2.8	3.8	-1.9	-1.9	-1.7	2.0	1.7	-0.2
Bone: trabecular spacing	1.6	2.3	4.5	2.1	1.6	1.4	-1.6	-1.5	-0.4
Bone: trabecular thickness	0.2	0.3	0.7	0.1	-0.8	-0.8	0.6	-0.0	-0.5
Bone: trabecular tissue density	1.0	1.8	4.1	2.0	1.1	1.0	-1.2	-1.6	-0.4
Water consumed over 24 hours	0.5	1.1	2.3	1.2	0.9	0.6	-1.0	-1.5	0.3
Number of responses in last shaping day	1.0	1.3	1.9	1.3	1.2	0.9	-1.3	-1.4	0.1