Scara5

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	gene expression	Scara5	0.09	0.06	5.3e-03	0.02	0.02	0.02	0.02	3.7e-02	4.2e-02	1.8e-02	2.9e-02
2	Brain	gene expression	Scara5	0.1	0.05	2.9e-10	0.1	0.11	0.11	0.11	6.2e-10	4.0e-10	3.6e-10	2.4e-10
3	Liver	gene expression	Scara5	0.03	0.02	1.4e-03	0.03	0.02	0.02	0.02	7.5e-04	4.0e-03	2.3e-03	2.7e-03
4	Adipose	gene expression	Scara5	0.53	0.12	0.0e+00	0.52	0.58	0.58	0.58	8.5e-68	6.2e-79	3.2e-78	2.4e-78
5	LHb	mRNA stability	Scara5	0.19	0.12	3.2e-03	0.04	0.03	0.01	0.03	3.9e-02	5.5e-02	2.0e-01	6.7e-02
6	Adipose	mRNA stability	Scara5	0.03	0.02	2.1e-03	0.03	0.02	0.03	0.03	3.2e-04	2.5e-03	1.4e-04	5.3e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	1.2	2.0	3.7	1.9	1.2	-1.5	1.5	1.1	-1.0
Area under the delay curve	0.4	0.4	1.3	-0.9	-0.1	0.3	-0.6	-1.1	-0.1
BMI with tail	0.4	1.4	2.1	-0.7	-1.4	1.4	-1.4	-1.2	0.4
BMI without tail	0.4	0.9	2.9	1.2	-0.8	0.2	0.2	0.6	-1.7
Body weight	0.2	0.6	1.7	0.3	0.1	0.3	-0.7	-1.2	1.3
Weight adjusted by age	1.5	1.7	6.6	-0.7	1.1	-0.1	-0.4	-1.4	2.6
Bone surface	0.9	1.6	3.0	1.7	1.5	-1.5	1.3	0.6	-0.3
Bone volume	1.1	1.9	4.2	2.0	1.5	-1.5	1.3	0.5	-0.9
Breakpoint value in progressive ratio session	0.8	0.9	2.2	1.2	0.3	-0.7	0.7	0.7	-1.5
Number of licking bursts	0.3	0.3	1.0	-0.3	-0.7	0.4	-0.2	0.2	-1.0
Context. condit. distance diff. score	1.9	2.3	6.4	-0.1	-2.5	1.4	-0.3	1.1	-2.1
Locomotion velocity, session 1	0.5	0.6	1.2	0.7	1.1	-1.0	0.7	0.5	-0.2
Locomotion distance, session 1	1.4	1.8	4.7	1.3	2.2	-1.8	1.1	0.0	-0.2
Locomotion velocity, session 2	0.7	0.8	2.3	0.8	1.5	-1.1	0.6	0.4	-0.2
Locomotion distance, session 2	2.2	3.0	7.2	1.9	2.7	-2.2	1.5	0.6	-0.3
Locomotion velocity, session 3	1.4	1.7	2.5	-1.3	-1.5	1.6	-1.4	-0.8	1.0
Locomotion distance, session 3	0.5	0.6	1.2	-0.8	-1.1	0.9	-0.7	-0.2	-0.5
Stereotopy head waving bouts, day 3	0.2	0.2	1.1	-0.2	0.3	-0.1	0.0	-0.4	1.1
Stereotopy head waving duration, day 3	1.2	1.5	4.1	-1.1	-0.1	0.6	-1.0	-1.5	2.0
Locomotion velocity, session 7	2.9	3.2	8.8	0.4	-2.3	1.0	0.2	2.0	-3.0
Locomotion distance, session 7	3.1	3.9	12.1	1.5	-1.1	-0.2	1.2	2.5	-3.5
Stereotopy head waving bouts, day 7	0.6	0.7	1.5	-0.7	0.1	0.5	-0.9	-1.0	1.2
Stereotopy head waving duration, day 7	2.0	2.4	5.4	-1.5	-0.5	1.1	-1.5	-1.7	2.3
Locomotion velocity, session 8	0.4	0.5	0.9	-0.9	-1.0	0.8	-0.6	-0.1	-0.6
Locomotion distance, session 8	0.6	0.8	2.6	0.9	-0.2	-0.3	0.6	1.0	-1.6
Degree of sensitization distance	4.2	4.2	9.7	2.2	-0.2	-1.0	1.7	2.6	-3.1
Degree of sensitization stereotypy	0.7	0.7	1.3	-0.9	-0.3	0.8	-1.1	-1.0	0.9
Conditioned locomotion	0.2	0.3	0.9	0.2	-0.5	0.0	0.3	0.5	-1.0
Cocaine response after cond. corrected	1.1	1.3	3.8	-0.6	-1.9	1.4	-0.8	-0.0	-1.0
Cocaine response after cond. not corrected	0.5	0.6	1.7	-0.4	-1.3	0.9	-0.5	0.3	-0.8
Cocaine response before conditioning	1.3	1.6	3.9	0.7	2.0	-1.6	1.2	0.8	0.5
Saline control response	0.4	0.5	1.5	0.3	1.2	-1.0	0.6	0.0	0.2
Bone: connectivity density	2.4	3.7	5.9	2.4	1.2	-1.9	2.3	2.1	-1.3
Bone: cortical apparent density	1.0	1.3	3.2	-0.9	-1.8	1.5	-1.1	0.0	-0.5
Bone: cortical area	0.3	0.4	1.3	-0.7	0.2	0.1	-0.6	-1.1	-0.3
Bone: cortical porosity	0.9	1.0	2.1	-1.3	0.8	-0.2	-0.4	-1.3	1.4
Bone: cortical porosity	1.0	1.1	1.9	-1.3	0.9	-0.2	-0.4	-1.4	1.4
Bone: cortical thickness	0.5	0.9	2.1	-1.4	-0.3	0.6	-1.0	-1.3	-0.3
Bone: cortical thickness	0.8	0.9	1.4	-1.1	-1.1	1.0	-1.0	-0.1	-1.2
Bone: cortical tissue density	1.1	1.5	3.7	-1.0	-1.9	1.6	-1.2	-0.0	-0.4
Condit. Reinf. active minus inactive responses	0.3	0.3	0.5	0.6	0.7	-0.3	0.0	-0.6	0.6
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.4	-0.2	-0.4	0.5	-0.5	-0.7	0.6
Condit. Reinf. active responses	0.8	1.0	2.5	1.2	1.6	-1.2	0.8	-0.2	0.2
Condit. Reinf. inactive responses	2.8	3.4	6.4	2.0	2.5	-2.2	1.8	1.0	-0.4
Incentive salience index mean	0.6	0.7	1.5	0.6	1.2	-0.5	-0.0	-1.0	0.9
Condit. Reinf. lever presses	0.8	1.0	3.5	0.9	1.9	-1.0	0.4	-0.5	0.6
Condit. Reinf. active minus inactive responses	0.5	0.6	1.1	0.6	0.9	-0.9	0.8	0.5	-1.0
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.4	-0.4	-0.6	0.6	-0.5	-0.3	-0.4
Condit. Reinf. active responses	0.8	1.1	1.5	0.9	1.1	-1.2	1.1	0.8	-1.0
Condit. Reinf. inactive responses	2.4	2.9	3.9	1.7	1.6	-2.0	2.0	1.8	-1.1
Condit. Reinf. lever presses	0.5	0.6	1.9	0.5	1.4	-0.9	0.4	-0.1	0.8
Condit. Reinf. lever reinforcers received	0.4	0.6	1.0	0.5	0.9	-1.0	0.8	0.5	-0.6
Conditioned reinforcement - actives	1.0	1.0	2.5	0.6	-0.2	-0.4	0.8	1.4	-1.6
Conditioned reinforcement - inactives	2.5	2.8	4.7	2.2	1.0	-1.3	1.5	2.2	-1.5
Conditioned locomotion	0.7	0.8	1.9	0.6	-0.8	0.0	0.3	1.4	-1.4
Patch foraging indifference point 0 sec	3.7	6.0	13.2	2.5	3.6	-3.1	2.4	0.9	0.6
Patch foraging indifference point AUC	3.6	4.1	7.7	-2.8	-2.4	2.2	-2.1	-1.3	0.2
Delay disc. indifference point, 0s delay	2.1	2.2	3.6	1.8	1.9	-1.7	1.5	1.1	-0.6
Delay disc. indifference point, 16s delay	0.9	0.9	2.4	-1.6	-0.6	0.6	-0.8	-1.2	-0.2
Delay disc. indifference point, 2s delay	0.8	0.9	2.4	0.9	1.5	-1.1	0.5	-0.5	0.3
Delay disc. indifference point, 24s delay	0.6	0.6	0.8	-0.7	-0.7	0.8	-0.9	-0.6	-0.7
Delay disc. indifference point, 4s delay	1.0	1.1	2.2	-1.1	-0.4	0.9	-1.2	-1.5	0.8
Delay disc. indifference point, 8s delay	1.1	1.1	2.7	-1.7	-0.6	0.7	-1.0	-1.4	0.0
Indifference point function ln k	1.1	1.5	3.2	1.4	1.8	-1.4	1.2	0.2	0.6
Indifference point function log k	1.1	1.5	3.2	1.4	1.8	-1.4	1.2	0.2	0.6
Patch foraging total patch changes 0 sec	3.1	5.0	12.0	2.1	3.5	-2.8	2.1	0.6	0.9
Patch foraging total patch changes 12 sec	0.4	0.5	1.3	-0.5	1.2	-1.1	0.6	0.1	0.4
Patch foraging total patch changes 18 sec	0.1	0.1	0.2	0.3	0.3	-0.5	0.3	0.4	-0.2
Patch foraging total patch changes 24 sec	0.7	0.8	2.8	-0.2	1.7	-1.2	0.5	-0.5	0.5
Patch foraging total patch changes 6 sec	0.1	0.1	0.3	-0.0	0.5	-0.6	0.3	0.1	-0.1
Patch foraging time to switch 0 sec	1.1	1.7	2.4	1.6	1.0	-1.3	1.4	1.3	-1.1
Patch foraging water rate 0 sec	0.4	0.7	1.3	-0.9	0.0	0.3	-0.7	-1.1	1.1
Patch foraging water rate 12 sec	0.3	0.4	1.0	-0.6	0.5	0.0	-0.3	-0.9	1.0
Patch foraging water rate 18 sec	3.5	4.7	6.8	-2.6	-1.3	2.1	-2.4	-2.4	1.9
Patch foraging water rate 24 sec	0.7	1.0	2.0	-0.7	-1.4	1.3	-1.0	-0.9	0.2
Patch foraging water rate 6 sec	1.6	2.3	4.7	-1.8	0.1	0.7	-1.2	-2.0	2.2
Seeking ratio, delayed vs. immediate footshock	1.6	1.8	2.5	1.6	1.4	-1.5	1.5	1.5	-0.2
Distance traveled before self-admin	0.3	0.3	0.6	-0.4	-0.1	0.4	-0.6	-0.8	0.6
Distance traveled after self-admin	0.6	0.6	1.0	-0.8	-0.6	0.9	-1.0	-0.7	0.7
Extensor digitorum longus weight	6.7	26.4	40.8	-5.4	-2.9	4.6	-5.7	-6.4	5.0
Bone: elastic displacement	1.2	1.3	3.5	1.0	1.9	-1.5	1.1	0.4	0.4
Bone: elastic work	1.6	2.1	6.4	0.9	2.5	-1.8	0.9	-0.5	1.0
Bone: endosteal estimation	0.1	0.3	0.8	0.9	0.8	-0.6	0.4	-0.0	-0.0
Bone: endosteal perimeter	0.7	1.4	2.8	1.5	1.7	-1.4	1.1	0.3	-0.2
Epididymis fat weight	0.6	1.4	3.1	1.8	0.6	-1.0	1.2	1.3	-1.0
Delta time in closed arm before/after self-admin	0.2	0.2	0.5	0.3	0.1	-0.3	0.6	0.7	-0.2
Delta time in open arm before/after self-admin	0.2	0.2	0.4	0.6	-0.4	-0.2	0.3	0.3	-0.6
Diff in mean of infusions in LGA sessions	0.4	0.5	1.3	0.9	0.5	-0.1	-0.2	-0.8	1.1
Delay discount exponential model param	0.8	0.9	2.1	1.3	0.4	-0.7	1.0	1.4	-0.2
Extinction: sum of active levers before priming	1.9	1.8	3.6	1.9	0.6	-1.0	1.3	1.3	-1.6
Active lever presses in extinction session 6	0.5	0.5	1.4	1.2	-0.5	0.2	0.2	0.9	-0.8
Bone: final force	0.2	0.3	1.0	-0.7	0.1	0.2	-0.5	-1.0	-0.0
Bone: final moment	0.2	0.4	1.3	-0.5	0.6	-0.1	-0.4	-1.1	0.3
Food consumed during 24 hour testing period	0.3	0.4	1.3	-0.5	0.1	0.2	-0.5	-0.7	1.2
Glucose	1.0	1.6	3.5	-1.0	-1.9	1.7	-1.4	-0.4	-0.1
Heart weight	0.1	0.1	0.2	0.5	0.0	0.0	-0.1	-0.4	0.4
Delay discount hyperbolic model param	0.8	0.9	2.4	1.1	0.2	-0.6	1.0	1.6	-0.5
Intermittent access intake day 1-15 change	0.3	0.3	0.4	0.6	0.6	-0.5	0.6	0.5	-0.0
Intermittent access intake escalation	0.1	0.1	0.1	0.3	0.3	-0.2	0.3	0.2	0.1
Intermittent access intake escalation 2	0.1	0.1	0.2	0.4	0.5	-0.2	0.3	0.2	0.5
Intermitt. access day 1 inactive lever presses	1.0	1.1	2.5	1.5	-0.3	-0.4	0.9	1.6	-0.9
Intermitt. access day 15 inactive lever presses	0.1	0.1	0.3	0.5	-0.4	0.3	-0.2	-0.2	0.4
Intermitt. access escalation Index	0.5	0.4	1.7	0.7	-0.3	0.1	0.0	0.2	-1.3
Intermittent access day 1 total infusions	0.9	1.0	2.7	-0.8	-1.6	1.2	-1.1	-0.2	-0.2
Intermittent access day 15 total infusions	0.3	0.4	1.2	-0.0	-1.1	0.6	-0.4	0.2	-0.5
Intermittent access terminal intake (last 3 days)	1.2	1.3	2.3	-1.2	-1.5	1.4	-1.2	-0.6	0.2
Intermittent access total infusions	0.7	0.8	2.5	-0.4	-1.6	1.0	-0.6	0.3	-0.8
Intermittent access day 1 locomotion	0.2	0.2	1.0	0.3	-0.4	-0.2	0.2	0.1	-1.0
Intermittent access day 15 total locomotion	0.3	0.3	1.4	-0.1	-1.2	0.7	-0.3	0.2	-0.3
Intermittent access total locomotion	0.1	0.1	0.5	-0.1	-0.7	0.2	-0.0	0.1	-0.5
Intermittent access standard deviation	0.9	0.9	3.6	-0.5	-0.0	0.6	-0.7	-0.9	1.9
Left kidney weight	0.8	2.3	3.6	-1.6	-0.6	1.3	-1.6	-1.9	1.9
Right kidney weight	0.4	1.1	2.4	0.9	1.5	-1.0	0.6	-0.6	1.3
Cocaine induced anxiety	0.4	0.4	0.7	0.5	0.7	-0.7	0.2	-0.9	0.8
Post-drug Anxiety	2.0	2.2	3.7	1.9	1.4	-1.9	1.8	0.4	-0.7
Baseline Anxiety	2.1	2.2	2.5	1.5	1.3	-1.4	1.6	1.5	-1.6
Tail length	0.6	1.9	2.7	1.6	1.4	-1.6	1.5	1.2	-0.6
Length with tail	0.3	1.0	2.6	0.8	1.6	-1.1	0.7	0.0	1.2
Length without tail	1.1	2.4	7.4	-1.2	0.5	0.5	-1.2	-2.0	2.7
Times rat made contact with spout	0.2	0.2	0.5	-0.6	-0.5	0.3	-0.3	-0.1	-0.7
Lifetime Intake	0.4	0.4	1.5	-0.2	-1.2	0.7	-0.4	0.3	-0.6
Liver weight, left	4.1	6.6	9.2	-3.0	-1.8	2.7	-2.9	-2.3	2.5
Liver weight, right	2.3	3.8	6.7	-2.6	-1.3	1.8	-2.1	-2.1	1.5
Locomotor activity	1.8	2.9	6.8	-0.1	2.6	-1.5	0.2	-1.6	2.4
Locomotor testing distance	3.5	5.9	15.7	1.6	4.0	-3.3	2.3	0.3	1.0
Locomotor testing rearing	6.2	9.5	23.2	2.1	4.8	-4.1	3.2	1.3	0.9
Locomotion in novel chamber	0.1	0.2	0.4	0.1	-0.2	0.5	-0.4	-0.3	-0.7
Locomotion in novel chamber post-restriction	0.8	0.9	1.6	-1.0	-0.9	0.9	-1.1	-1.3	0.2
Fecal boli incidents, locomotor time 1	3.5	3.8	11.0	-3.3	-0.8	1.5	-1.8	-1.5	1.8
Change in fecal boli incidents, locomotor task	1.0	0.9	4.1	2.0	-0.6	-0.0	0.5	0.8	-0.3
Time >=10cm from walls, locomotor time 1	0.8	0.8	1.7	0.4	1.3	-1.3	1.1	0.4	0.3
Bouts of movement, locomotor time 1	0.8	0.9	2.1	-1.5	-0.2	1.0	-0.9	-0.7	0.8
Total resting periods, locomotor time 1	1.3	1.4	3.0	-1.7	-1.0	1.4	-1.2	-0.7	0.5
Rest time, locomotor task time 1	2.0	2.2	5.9	-2.4	-1.6	1.7	-1.4	-0.2	0.4
Distance moved, locomotor task time 1	1.5	1.7	3.4	1.8	1.4	-1.5	1.3	0.6	-0.6
Vertical activity count, locomotor time 1	1.3	1.3	3.8	0.9	1.9	-1.4	0.7	-0.7	0.9
Time >=10cm from walls, locomotor time 2	0.2	0.2	1.2	-0.3	-0.0	0.1	-0.1	0.0	1.1
Bouts of movement, locomotor time 2	1.2	1.3	2.0	-1.4	-1.1	1.4	-1.3	-1.0	0.2
Total resting periods, locomotor time 2	2.7	2.9	4.4	-2.1	-1.8	2.1	-1.8	-1.4	0.5
Rest time, locomotor task time 2	9.1	10.5	22.6	-4.8	-3.3	3.5	-3.3	-2.1	1.4
Distance moved, locomotor task time 2	4.3	5.0	10.4	3.2	2.5	-2.5	2.1	1.3	-0.7
Vertical activity count, locomotor time 2	2.1	2.3	5.0	1.8	2.2	-1.9	1.2	0.5	0.0
Light reinforcement 1	0.7	1.2	2.8	1.0	0.3	-0.8	1.0	1.2	-1.7
Light reinforcement 2	0.9	1.2	3.3	-0.7	-1.8	1.1	-0.5	0.6	-1.3
Bone: marrow area	0.2	0.4	0.9	0.9	0.8	-0.6	0.4	0.1	-0.1
Bone: maximum diameter	0.3	0.6	1.5	-0.9	-0.3	0.6	-1.0	-1.2	-0.1
Bone: maximum force	0.3	0.6	1.8	-0.8	0.4	0.1	-0.8	-1.3	0.2
Bone: maximum moment	0.4	0.6	1.9	-0.6	0.9	-0.2	-0.5	-1.4	0.5
Mean time between licks in bursts	3.3	4.6	6.5	2.4	1.3	-2.2	2.6	2.4	-1.7
Mean num. licks in bursts	0.1	0.1	0.2	-0.1	0.3	-0.1	-0.1	-0.2	0.5
Cd content in liver	0.1	0.1	0.2	0.0	0.4	-0.4	0.4	0.3	-0.0
Co content in liver	1.7	2.0	3.7	-1.1	-1.9	1.6	-1.7	-1.3	-0.1
Cu content in liver	1.1	1.3	2.0	-1.4	-1.4	1.1	-1.1	-0.9	1.0
Fe content in liver	0.5	0.6	2.0	0.7	0.2	-0.5	0.9	1.4	-0.1
K content in liver	0.7	0.7	1.7	1.1	-0.0	-0.4	0.7	0.9	-1.3
Mg content in liver	0.4	0.4	1.1	0.5	-0.1	-0.4	0.7	0.7	-1.1
Mn content in liver	3.0	3.4	5.9	2.4	0.9	-1.6	1.8	1.9	-2.0
Na content in liver	2.6	2.8	8.9	-0.7	1.8	-0.6	-0.3	-1.9	3.0
Rb content in liver	0.3	0.3	0.8	0.0	-0.9	0.5	0.0	0.8	-0.5
Se content in liver	3.2	3.9	6.6	2.3	2.4	-2.6	2.2	1.2	0.1
Sr content in liver	1.0	0.9	1.6	1.0	0.5	-1.1	1.3	1.2	-0.3
Zn content in liver	0.8	0.9	2.8	-1.0	0.7	-0.4	-0.2	-1.2	1.7
Bone: minimum diameter	0.3	0.5	1.2	-0.5	1.0	-0.4	-0.3	-1.1	0.3
Time in familiar zone, hab. session 1	0.3	0.3	0.9	0.5	0.1	-0.2	0.3	0.7	-0.9
Time in novel zone, hab. session 1	2.2	2.2	3.3	-1.8	-1.4	1.6	-1.6	-1.2	1.1
Total zone transitions, hab. session 1	0.2	0.2	1.0	0.1	1.0	-0.5	-0.0	-0.4	0.2
Total locomotion distance, hab. session 1	0.9	1.2	2.9	1.1	1.7	-1.4	0.9	0.5	-0.4
Locomotion velocity, hab. session 1	2.1	2.9	6.5	1.9	2.5	-2.1	1.5	0.6	-0.4
Time in familiar zone, hab. session 2	0.5	0.5	1.4	-0.6	-1.2	0.8	-0.4	0.2	-0.5
Time in novel zone, hab. session 2	0.2	0.2	0.8	0.2	0.9	-0.6	0.3	-0.1	0.1
Total zone transitions, hab. session 2	0.4	0.5	1.2	0.4	1.1	-0.4	-0.2	-0.7	1.0
Total locomotion distance, hab. session 2	0.3	0.3	1.0	0.6	1.0	-0.7	0.3	-0.1	0.2
Locomotion velocity, hab. session 2	0.3	0.4	1.3	0.5	1.2	-0.7	0.1	-0.4	0.4
Novel to familiar place preference ratio	0.4	0.5	1.1	0.5	1.0	-0.8	0.5	0.6	-0.2
Novelty place preference	0.6	0.6	1.3	0.6	1.2	-1.0	0.7	0.7	-0.2
Time in novel zone, NPP test	0.5	0.6	1.4	0.6	1.2	-1.0	0.7	0.5	-0.0
Total zone transitions, NPP test	1.2	1.6	3.2	1.4	1.8	-1.7	1.3	0.4	-0.3
Total locomotion distance, NPP test	4.8	6.6	9.1	3.0	2.7	-3.0	2.8	2.0	-1.6
Locomotion velocity, NPP test	3.8	5.4	7.3	2.7	2.4	-2.6	2.5	2.0	-1.6
Intraocular pressure	1.5	2.1	4.1	2.0	1.2	-1.5	1.6	1.2	-0.8
Delta distance traveled before/after self-admin	0.7	0.8	1.3	-0.7	-0.9	1.1	-1.0	-0.4	0.9
Delta ambulatory time before/after self-admin	0.5	0.6	1.0	-0.5	-0.6	1.0	-0.9	-0.5	1.0
Parametrial fat weight	2.6	5.0	7.5	2.3	1.0	-2.0	2.3	2.7	-2.7
Pavlov. Cond. lever latency	0.2	0.3	0.8	-0.5	-0.9	0.3	-0.0	0.3	-0.6
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	0.3	0.0	0.2	-0.2	-0.4	0.4
Pavlov. Cond. change in total contacts	1.2	1.3	3.2	-0.8	0.7	0.3	-1.0	-1.5	1.8
Pavlov. Cond. index score	0.3	0.4	1.1	0.1	0.4	0.2	-0.5	-0.8	1.0
Pavlov. Cond. latency score	0.2	0.3	1.0	0.2	0.6	0.0	-0.3	-0.6	1.0
Pavlov. Cond. lever contacts	0.3	0.3	1.3	0.1	0.6	0.0	-0.2	-0.5	1.1
Pavlov. Cond. magazine entry number	0.4	0.5	1.1	0.5	0.1	-0.6	0.8	1.0	-1.0
Pavlov. Cond. intertrial magazine entries	0.9	1.1	2.5	1.1	1.6	-1.4	1.0	0.3	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	1.7	-0.3	0.3	0.4	-0.7	-1.0	1.3
Pavlov. Cond. response bias	0.7	0.8	1.4	-0.6	-0.3	0.9	-1.0	-1.2	1.2
Pavlov. Cond. lever latency	1.0	1.4	5.0	0.7	-0.4	-0.3	0.8	1.4	-2.2
Pavlov. Cond. magazine entry latency	0.2	0.2	0.5	0.3	0.7	-0.2	-0.1	-0.6	0.7
Pavlov. Cond. change in total contacts	2.1	2.9	7.3	-1.4	0.1	0.8	-1.5	-2.4	2.7
Pavlov. Cond. index score	0.8	1.0	3.2	-0.4	0.7	0.1	-0.6	-1.4	1.8
Pavlov. Cond. latency score	0.7	0.9	2.9	-0.2	0.9	-0.2	-0.3	-1.2	1.7
Pavlov. Cond. lever contacts	0.9	1.3	4.7	-0.4	1.0	-0.1	-0.6	-1.2	2.2
Pavlov. Cond. magazine entry number	0.2	0.3	0.8	-0.6	-0.9	0.6	-0.2	0.2	-0.2
Pavlov. Cond. intertrial magazine entries	6.1	7.9	10.5	2.9	1.8	-2.7	3.2	3.2	-2.8
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.0	3.1	-0.5	0.5	0.2	-0.7	-1.3	1.8
Pavlov. Cond. response bias	0.8	1.1	3.4	-0.3	1.0	-0.1	-0.6	-1.3	1.8
Time in closed arm before self-admin	0.5	0.5	1.4	-0.4	-0.6	0.5	-0.7	-1.2	0.7
Time in closed arm after self-admin	0.2	0.2	1.1	1.1	0.2	-0.2	0.3	-0.0	0.0
Time in open arm before self-admin	0.2	0.2	0.9	0.2	0.9	-0.4	0.4	0.1	-0.3
Time in open arm after self-admin	0.2	0.2	0.4	0.6	-0.1	-0.2	0.5	0.5	-0.6
Bone: periosteal estimation	0.1	0.2	0.4	0.2	0.6	-0.3	-0.1	-0.6	-0.3
Bone: periosteal perimeter	0.3	0.5	1.3	0.6	1.1	-0.9	0.5	-0.0	-0.5
Bone: post-yield work	1.7	2.3	3.6	-1.2	-1.9	1.6	-1.5	-0.7	-1.9
Progressive ratio test 1 active lever presses	2.1	2.2	5.4	-1.4	-2.3	1.8	-1.5	-0.7	-0.4
Progressive ratio test 1 breakpoint	2.2	2.3	5.4	-1.5	-2.3	1.8	-1.5	-0.6	-0.5
Progressive ratio test 1 inactive lever presses	0.6	0.6	2.0	1.4	-0.4	-0.3	0.7	0.8	-0.7
Progressive ratio test 2 active lever presses	1.3	1.4	4.0	-0.1	-2.0	1.6	-1.1	0.2	-0.6
Progressive ratio test 2 breakpoint	1.0	1.1	3.0	-0.1	-1.7	1.5	-1.1	0.2	-0.4
Progressive ratio test 2 inactive lever presses	0.3	0.4	1.3	0.4	-1.2	0.5	-0.2	0.6	-0.4
Incentive Sensitization - Responses	0.3	0.3	0.8	0.9	-0.3	0.5	-0.3	0.7	0.3
Incentive Sensitization - Breakpoint	0.3	0.3	1.0	1.0	-0.2	0.4	-0.2	0.8	0.2
Sum of active levers in priming session hrs 5-6	0.5	0.5	1.3	0.4	-0.6	0.2	0.3	0.8	-1.2
Progressive ratio	0.6	0.7	1.6	-1.0	0.2	0.5	-0.7	-1.0	1.3
Food seeking constrained by brief footshock	1.3	1.6	3.8	-1.3	-1.9	1.7	-1.0	0.4	-0.6
Seeking ratio, punishment vs. effort	0.4	0.5	1.4	-0.3	-1.2	0.7	-0.2	0.5	-0.7
Retroperitoneal fat weight	0.3	1.1	2.2	1.5	-0.2	-0.4	0.8	1.4	-1.4
Reaction time number correct	0.2	0.3	0.7	0.8	-0.7	0.5	-0.1	0.5	-0.2
Reaction time mean minus median	0.3	0.3	0.6	0.7	0.7	-0.6	0.3	-0.4	0.7
Reaction time mean minus median AUC	0.2	0.3	1.3	1.1	0.4	-0.4	0.3	0.1	0.2
Reaction time num false alarms	0.5	0.6	1.5	1.2	1.1	-0.9	0.6	0.2	0.3
Reaction time num false alarms AUC	0.2	0.2	0.5	0.5	0.7	-0.4	0.2	-0.2	0.5
Reaction time trials correct on left	0.2	0.3	0.7	0.8	-0.7	0.5	-0.1	0.5	-0.2
Reaction time trials on left	0.2	0.3	0.8	0.9	-0.6	0.4	0.0	0.6	-0.3
Reaction time mean	0.1	0.1	0.4	-0.2	-0.0	0.1	-0.1	-0.6	0.7
Reaction time mean AUC	0.2	0.2	0.8	-0.1	0.2	-0.0	-0.0	-0.8	0.9
Median of all reaction times	0.1	0.1	0.2	-0.3	-0.3	0.3	-0.2	-0.4	0.5
Reaction time omissions	1.5	2.0	3.1	1.5	1.0	-1.4	1.7	1.8	-0.9
Reaction time false alarm rate	0.1	0.2	0.5	0.0	0.7	-0.5	0.2	-0.3	0.4
Reaction time premature initiation rate	0.3	0.4	0.6	-0.5	-0.6	0.6	-0.8	-0.6	0.5
Reaction time premature initiations	0.3	0.5	1.0	-0.2	-1.0	0.9	-0.8	-0.4	0.3
Std. dev. reaction times	0.0	0.1	0.1	0.4	0.0	0.0	-0.0	-0.3	0.4
Reaction time trials completed	0.2	0.3	0.8	0.9	-0.6	0.4	0.0	0.6	-0.3
Reaction time trials AUC	0.2	0.2	0.6	0.8	-0.6	0.4	0.0	0.5	-0.2
Run reversals in cocaine runway, females	0.6	0.6	1.8	0.7	0.2	-0.7	0.8	0.5	-1.3
Run reversals in cocaine runway, males	5.8	5.6	8.1	-2.9	-1.5	2.1	-2.7	-2.6	2.2
Latency to leave start box in cocaine runway	0.8	0.8	1.7	-0.6	-1.3	1.0	-0.9	-0.5	0.9
Latency to leave start box in cocaine runway, F	1.4	1.6	2.5	-0.8	-1.2	1.4	-1.4	-1.0	1.6
Latency to leave start box in cocaine runway, M	0.4	0.4	1.1	-0.2	0.2	-0.8	1.0	0.6	-0.4
Std. dev. time between licks in bursts	6.4	7.6	11.6	2.9	3.2	-3.4	3.1	2.1	-1.1
Total sessions with >9 infusions	0.4	0.5	1.0	0.5	-0.4	-0.3	0.6	1.0	-1.0
Short access day 1 total inactive lever presses	1.5	1.6	3.1	-1.6	-1.8	1.4	-1.2	-0.8	0.4
Short access day 10 total inactive lever presses	0.8	0.9	2.4	1.0	-0.3	-0.3	0.6	1.2	-1.6
Short access day 1 total infusions	0.6	0.7	2.7	-0.1	-1.6	0.9	-0.5	0.4	-0.3
Short access day 10 total infusions	0.4	0.4	0.8	-0.9	-0.7	0.5	-0.8	-0.4	-0.2
Short access total infusions	0.2	0.2	0.8	-0.5	-0.9	0.5	-0.5	-0.0	-0.0
Short access day 1 locomotion	0.0	0.0	0.2	-0.0	0.2	-0.1	-0.0	0.0	0.4
Short access day 10 total locomotion	0.4	0.4	0.7	0.6	0.5	-0.8	0.8	0.5	-0.7
Short access total locomotion	0.4	0.4	0.8	0.3	0.6	-0.9	0.8	0.5	-0.4
One hour access (0.3 mA shock)	0.2	0.3	0.9	0.1	-0.6	0.5	-0.5	0.1	-0.9
Compulsive drug intake	1.2	1.3	3.2	1.5	0.6	-0.8	0.6	0.8	-1.8
One hour access (shock baseline)	0.4	0.5	0.9	-0.5	-1.0	0.9	-0.8	-0.4	0.3
Social response proportion	0.6	0.7	1.9	0.5	-1.4	0.7	0.1	1.1	-0.6
Social responses	3.8	4.9	9.4	3.1	1.1	-1.8	2.4	2.5	-1.7
Social time	0.8	1.0	2.2	0.6	1.5	-1.3	1.0	0.3	0.7
Soleus weight	0.4	1.1	1.6	-0.9	-1.2	1.2	-1.3	-1.0	-0.0
Bone: stiffness	0.5	0.8	2.0	-1.4	-0.6	0.8	-1.0	-0.9	0.1
Tibialis anterior weight	4.8	16.3	27.4	-4.0	-1.9	3.4	-4.4	-5.2	4.4
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.3	-0.3	0.5	-0.4	0.2	-0.1	-0.2
Time to tail flick, vehicle, after self-admin	1.6	1.7	3.4	-1.8	-1.0	1.1	-1.1	-1.7	0.5
Time to tail flick, test, before self-admin	0.5	0.5	0.8	0.7	0.8	-0.9	0.6	-0.6	-0.3
Time to tail flick, test, after self-admin	3.7	3.8	8.2	2.5	0.3	-1.1	1.9	1.9	-2.9
Delta time to tail flick, vehicle, before/after SA	1.2	1.2	1.9	-1.3	-1.4	1.1	-0.8	-1.0	0.5
Delta time to tail flick, test, before/after SA	1.6	1.4	3.6	0.4	-1.1	0.3	0.6	1.9	-1.8
Tibia length	1.5	4.2	10.5	1.5	3.2	-2.6	1.9	0.3	1.5
Ambulatory time before self-admin	0.1	0.1	0.3	-0.2	-0.1	0.3	-0.6	-0.5	0.1
Ambulatory time after self-admin	1.0	1.1	1.6	-0.9	-0.5	1.1	-1.3	-1.2	1.2
Bone: tissue strength	0.3	0.3	0.6	0.5	0.8	-0.7	0.4	-0.1	-0.2
Total heroin consumption	1.2	1.4	2.9	-1.7	-0.4	1.0	-1.4	-1.2	1.1
Bone: trabecular number	1.7	2.7	4.5	2.1	1.2	-1.7	1.8	1.5	-1.3
Bone: trabecular spacing	1.2	1.5	2.4	-1.4	-0.8	1.2	-1.6	-1.3	0.8
Bone: trabecular thickness	0.4	0.5	0.9	1.0	0.9	-0.8	0.5	-0.1	-0.7
Bone: trabecular tissue density	0.7	1.0	1.5	-1.1	-0.5	0.9	-1.2	-1.2	1.0
Water consumed over 24 hours	0.9	1.0	2.2	-1.2	-0.5	0.5	-0.9	-1.5	1.0
Number of responses in last shaping day	0.5	0.5	1.8	-0.2	0.8	-0.4	-0.0	-0.5	1.3