Ppp2r5b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	Ppp2r5b	0.05	0.03	1.9e-06	0.01	0.02	0.02	0.01	4.8e-02	1.1e-03	8.8e-04	5.7e-03
2	Brain	isoform ratio	NM_181379.3	0.07	0.05	4.3e-05	0.06	0.05	0.06	0.06	5.0e-06	2.9e-05	6.6e-06	7.4e-06
3	Brain	gene expression	Ppp2r5b	0.09	0.05	1.8e-07	0.07	0.07	0.07	0.07	2.8e-07	3.6e-07	4.1e-07	3.3e-07
4	Adipose	gene expression	Ppp2r5b	0.19	0.08	5.6e-17	0.11	0.1	0.1	0.1	2.7e-12	1.5e-11	1.2e-11	3.1e-11
5	Adipose	mRNA stability	Ppp2r5b	0.05	0.03	4.8e-04	0	0.02	0	0.01	1.6e-01	6.6e-03	7.9e-02	2.7e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.2	0.3	0.8	-0.2	-0.4	0.5	0.4	-0.9
Area under the delay curve	0.1	0.1	0.4	-0.2	-0.1	0.2	0.1	-0.6
BMI with tail	2.2	7.1	14.2	0.3	-2.7	2.6	2.7	-3.8
BMI without tail	1.8	3.6	7.3	0.5	-1.8	2.0	1.8	-2.7
Body weight	3.2	13.6	16.2	2.6	-4.0	3.8	3.9	-4.0
Weight adjusted by age	1.5	1.7	2.4	1.5	-1.6	1.2	1.3	-0.9
Bone surface	1.7	2.9	3.5	1.3	-1.9	1.8	1.9	-1.6
Bone volume	0.2	0.4	0.4	0.3	-0.7	0.7	0.7	-0.6
Breakpoint value in progressive ratio session	2.0	2.2	3.0	1.7	-1.5	1.5	1.5	-1.1
Number of licking bursts	0.1	0.1	0.2	0.4	-0.3	0.3	0.3	-0.2
Context. condit. distance diff. score	1.2	1.4	2.2	-1.5	1.3	-1.1	-1.3	0.7
Locomotion velocity, session 1	0.2	0.3	0.4	0.3	-0.6	0.5	0.6	-0.6
Locomotion distance, session 1	0.8	1.0	2.1	0.2	-1.1	0.9	1.1	-1.5
Locomotion velocity, session 2	2.8	3.3	3.8	1.4	-1.9	1.9	1.9	-2.0
Locomotion distance, session 2	1.1	1.5	2.5	0.5	-1.3	1.1	1.3	-1.6
Locomotion velocity, session 3	0.3	0.4	1.5	-1.2	0.1	-0.4	-0.1	-0.4
Locomotion distance, session 3	0.0	0.0	0.1	-0.3	0.1	-0.0	-0.1	-0.1
Stereotopy head waving bouts, day 3	0.6	0.7	2.6	-1.6	0.3	-0.7	-0.3	-0.3
Stereotopy head waving duration, day 3	0.7	0.8	1.9	-1.4	0.7	-1.0	-0.7	0.3
Locomotion velocity, session 7	0.8	0.8	2.6	-1.6	0.6	-0.9	-0.6	-0.1
Locomotion distance, session 7	0.2	0.2	0.5	-0.6	-0.2	-0.0	0.2	-0.7
Stereotopy head waving bouts, day 7	0.5	0.6	0.8	-0.9	0.8	-0.7	-0.8	0.7
Stereotopy head waving duration, day 7	0.3	0.3	0.5	0.5	-0.6	0.7	0.6	-0.5
Locomotion velocity, session 8	1.6	2.0	2.3	1.0	-1.5	1.5	1.5	-1.4
Locomotion distance, session 8	0.2	0.3	1.3	-1.1	0.3	-0.3	-0.3	-0.3
Degree of sensitization distance	0.2	0.2	0.5	-0.7	-0.1	-0.1	0.1	-0.6
Degree of sensitization stereotypy	0.0	0.0	0.0	0.2	-0.0	0.2	0.1	0.1
Conditioned locomotion	1.7	2.0	2.4	1.2	-1.5	1.4	1.5	-1.3
Cocaine response after cond. corrected	0.6	0.6	1.4	-1.2	0.7	-0.8	-0.7	0.2
Cocaine response after cond. not corrected	0.5	0.5	1.3	-1.1	0.7	-0.7	-0.6	0.1
Cocaine response before conditioning	0.2	0.3	0.5	0.7	-0.4	0.6	0.4	-0.2
Saline control response	4.6	6.0	6.8	2.1	-2.6	2.6	2.5	-2.3
Bone: connectivity density	1.4	2.2	2.9	0.9	-1.5	1.6	1.5	-1.7
Bone: cortical apparent density	0.4	0.5	1.2	1.1	-0.7	0.6	0.7	-0.4
Bone: cortical area	0.2	0.3	0.4	0.6	-0.6	0.6	0.6	-0.3
Bone: cortical porosity	0.0	0.0	0.1	0.1	-0.2	0.1	0.2	-0.4
Bone: cortical porosity	0.5	0.6	0.7	0.7	-0.8	0.7	0.8	-0.8
Bone: cortical thickness	3.1	5.1	7.0	2.7	-2.2	2.3	2.3	-1.7
Bone: cortical thickness	1.4	1.6	1.9	1.4	-1.3	1.3	1.3	-1.1
Bone: cortical tissue density	0.5	0.7	1.5	1.2	-0.8	0.7	0.8	-0.5
Condit. Reinf. active minus inactive responses	0.2	0.2	0.3	0.3	-0.5	0.4	0.5	-0.6
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	0.5	-0.2	0.1	0.2	-0.1
Condit. Reinf. active responses	0.0	0.0	0.0	-0.2	-0.0	-0.0	-0.0	-0.2
Condit. Reinf. inactive responses	0.3	0.4	1.0	-1.0	0.5	-0.5	-0.5	0.1
Incentive salience index mean	0.3	0.4	0.8	0.2	-0.6	0.6	0.6	-0.9
Condit. Reinf. lever presses	0.1	0.2	0.3	0.0	-0.4	0.4	0.4	-0.6
Condit. Reinf. active minus inactive responses	0.5	0.7	0.7	-0.7	0.8	-0.8	-0.8	0.9
Condit. Reinf. active-inactive response ratio	2.2	2.3	2.6	-1.6	1.5	-1.6	-1.5	1.4
Condit. Reinf. active responses	0.0	0.0	0.0	-0.0	0.1	-0.2	-0.1	0.2
Condit. Reinf. inactive responses	0.7	0.9	1.0	0.9	-1.0	0.9	0.9	-1.0
Condit. Reinf. lever presses	0.6	0.8	1.1	1.0	-1.0	0.9	1.0	-0.5
Condit. Reinf. lever reinforcers received	0.0	0.0	0.1	0.3	-0.2	0.1	0.2	0.1
Conditioned reinforcement - actives	0.9	0.9	2.0	-0.6	0.9	-0.8	-0.8	1.4
Conditioned reinforcement - inactives	8.4	9.4	11.8	-2.3	3.2	-3.2	-3.1	3.4
Conditioned locomotion	9.6	11.5	13.3	-2.8	3.5	-3.5	-3.5	3.6
Patch foraging indifference point 0 sec	0.0	0.1	0.1	-0.2	0.4	-0.2	-0.3	0.3
Patch foraging indifference point AUC	2.2	2.5	4.0	2.0	-1.6	1.7	1.5	-1.0
Delay disc. indifference point, 0s delay	0.2	0.2	0.6	-0.7	0.0	0.1	-0.0	-0.7
Delay disc. indifference point, 16s delay	1.2	1.2	1.7	-1.1	1.0	-1.3	-1.1	0.9
Delay disc. indifference point, 2s delay	0.1	0.1	0.4	-0.6	0.3	-0.1	-0.3	-0.1
Delay disc. indifference point, 24s delay	0.1	0.1	0.1	0.4	-0.3	0.3	0.3	-0.4
Delay disc. indifference point, 4s delay	0.2	0.2	0.7	-0.1	-0.3	0.4	0.2	-0.8
Delay disc. indifference point, 8s delay	0.2	0.2	0.6	0.0	-0.5	0.5	0.4	-0.8
Indifference point function ln k	5.0	6.9	10.6	-3.3	2.7	-2.8	-2.6	1.6
Indifference point function log k	5.0	6.9	10.6	-3.3	2.7	-2.8	-2.6	1.6
Patch foraging total patch changes 0 sec	0.0	0.0	0.0	0.1	0.1	0.0	-0.1	0.1
Patch foraging total patch changes 12 sec	3.5	4.6	5.3	2.3	-2.2	2.3	2.1	-1.8
Patch foraging total patch changes 18 sec	0.2	0.3	0.4	0.6	-0.4	0.6	0.4	-0.4
Patch foraging total patch changes 24 sec	2.0	2.5	3.6	1.9	-1.6	1.6	1.6	-1.1
Patch foraging total patch changes 6 sec	0.9	1.3	1.5	0.9	-1.1	1.2	1.2	-1.2
Patch foraging time to switch 0 sec	0.8	1.2	1.7	0.4	-1.1	1.2	1.2	-1.3
Patch foraging water rate 0 sec	3.0	4.8	5.8	-1.6	2.2	-2.3	-2.4	2.4
Patch foraging water rate 12 sec	4.1	6.3	7.2	-2.2	2.6	-2.7	-2.7	2.4
Patch foraging water rate 18 sec	1.4	1.9	2.3	-1.5	1.3	-1.5	-1.5	1.0
Patch foraging water rate 24 sec	2.3	3.3	3.8	-1.7	1.8	-2.0	-1.9	1.7
Patch foraging water rate 6 sec	1.7	2.4	3.1	-1.5	1.5	-1.8	-1.7	1.3
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.1	-0.3	-0.0	-0.3	-0.1	-0.1
Distance traveled before self-admin	0.2	0.2	0.3	0.6	-0.5	0.5	0.4	-0.0
Distance traveled after self-admin	0.1	0.1	0.4	0.6	-0.2	0.1	0.1	0.2
Extensor digitorum longus weight	6.8	26.9	29.9	4.5	-5.5	5.4	5.4	-5.0
Bone: elastic displacement	0.2	0.2	0.2	-0.2	0.5	-0.5	-0.5	0.5
Bone: elastic work	1.6	2.0	2.2	1.4	-1.5	1.5	1.5	-1.4
Bone: endosteal estimation	1.4	2.9	7.2	-2.7	1.5	-1.5	-1.5	0.7
Bone: endosteal perimeter	2.3	4.8	8.7	-3.0	2.1	-2.1	-2.1	1.5
Epididymis fat weight	3.0	6.9	9.1	-3.0	2.7	-2.6	-2.6	2.1
Delta time in closed arm before/after self-admin	0.8	0.8	1.7	0.3	-0.8	0.8	0.8	-1.3
Delta time in open arm before/after self-admin	0.3	0.3	0.9	0.5	0.4	-0.3	-0.4	0.9
Diff in mean of infusions in LGA sessions	0.4	0.4	1.1	1.1	-0.5	0.6	0.5	-0.2
Delay discount exponential model param	0.1	0.1	0.4	0.1	0.2	-0.3	-0.2	0.6
Extinction: sum of active levers before priming	3.6	3.6	4.2	1.8	-1.9	2.0	1.9	-1.8
Active lever presses in extinction session 6	1.4	1.3	2.5	1.6	-1.1	1.2	1.2	-0.4
Bone: final force	2.0	3.2	3.9	1.4	-2.0	1.9	2.0	-1.7
Bone: final moment	1.7	2.8	3.4	1.4	-1.8	1.8	1.8	-1.6
Food consumed during 24 hour testing period	0.2	0.2	0.5	0.6	0.2	-0.2	-0.2	0.7
Glucose	2.2	3.2	5.6	-2.4	1.7	-1.9	-1.7	1.0
Heart weight	2.6	3.7	4.9	-2.2	1.9	-2.1	-2.0	1.3
Delay discount hyperbolic model param	0.1	0.1	0.4	0.1	0.2	-0.3	-0.2	0.6
Intermittent access intake day 1-15 change	1.6	1.5	3.0	-0.5	1.2	-1.2	-1.2	1.7
Intermittent access intake escalation	1.3	1.3	2.3	-0.6	1.2	-1.1	-1.1	1.5
Intermittent access intake escalation 2	0.7	0.7	1.9	0.1	0.8	-0.8	-0.7	1.4
Intermitt. access day 1 inactive lever presses	2.9	3.1	3.5	-1.6	1.9	-1.8	-1.8	1.7
Intermitt. access day 15 inactive lever presses	4.2	4.6	5.9	-1.8	2.1	-2.2	-2.1	2.4
Intermitt. access escalation Index	2.1	1.8	3.2	-1.8	1.4	-1.3	-1.4	0.4
Intermittent access day 1 total infusions	6.7	7.8	13.6	-3.7	2.6	-2.7	-2.7	1.9
Intermittent access day 15 total infusions	11.3	12.7	14.0	-3.7	3.6	-3.6	-3.6	3.4
Intermittent access terminal intake (last 3 days)	8.8	9.7	11.9	-3.5	3.0	-3.1	-3.1	2.9
Intermittent access total infusions	7.1	7.9	11.3	-3.4	2.7	-2.8	-2.7	2.4
Intermittent access day 1 locomotion	4.1	4.3	9.4	-3.1	1.9	-1.9	-2.0	0.9
Intermittent access day 15 total locomotion	7.1	7.7	8.1	-2.8	2.8	-2.8	-2.8	2.6
Intermittent access total locomotion	9.0	10.3	15.1	-3.9	3.1	-3.2	-3.2	2.6
Intermittent access standard deviation	1.9	2.0	3.1	-0.9	1.5	-1.4	-1.3	1.7
Left kidney weight	0.9	2.5	2.9	-1.5	1.7	-1.4	-1.7	1.5
Right kidney weight	0.5	1.5	2.6	-0.8	1.2	-1.1	-1.2	1.6
Cocaine induced anxiety	0.0	0.0	0.2	-0.1	0.2	-0.1	-0.1	0.4
Post-drug Anxiety	0.6	0.6	0.9	0.9	-0.9	0.9	0.9	-0.2
Baseline Anxiety	2.4	2.5	2.8	1.6	-1.6	1.7	1.7	-1.4
Tail length	1.1	3.4	5.6	2.4	-1.7	2.0	1.7	-1.3
Length with tail	2.0	7.5	9.5	3.1	-2.9	2.8	2.7	-2.1
Length without tail	1.6	3.5	4.9	1.9	-2.2	1.7	2.1	-1.5
Times rat made contact with spout	0.9	1.0	1.3	1.1	-1.0	1.0	1.0	-1.0
Lifetime Intake	5.6	6.3	10.2	-3.2	2.4	-2.5	-2.4	1.9
Liver weight, left	0.1	0.1	0.3	-0.5	0.2	-0.2	-0.3	0.0
Liver weight, right	0.1	0.2	0.4	-0.6	-0.1	0.2	0.1	-0.6
Locomotor activity	0.6	1.0	1.2	-0.9	1.0	-1.0	-1.1	0.9
Locomotor testing distance	0.6	1.1	1.4	-1.0	1.0	-1.1	-1.2	0.8
Locomotor testing rearing	0.7	1.0	1.4	-1.0	1.0	-1.1	-1.2	0.8
Locomotion in novel chamber	6.9	8.5	9.8	-2.7	2.8	-3.1	-3.0	3.0
Locomotion in novel chamber post-restriction	3.5	4.3	4.9	-2.2	2.1	-2.0	-2.1	1.9
Fecal boli incidents, locomotor time 1	0.3	0.3	0.6	-0.2	0.6	-0.5	-0.6	0.8
Change in fecal boli incidents, locomotor task	0.7	0.7	1.5	-0.2	-0.8	0.7	0.7	-1.2
Time >=10cm from walls, locomotor time 1	2.0	2.0	3.5	-1.9	1.4	-1.4	-1.3	0.9
Bouts of movement, locomotor time 1	1.5	1.6	4.7	2.2	-1.3	0.8	0.9	-0.2
Total resting periods, locomotor time 1	0.9	0.9	3.1	1.8	-1.0	0.6	0.6	-0.0
Rest time, locomotor task time 1	1.3	1.4	2.0	-0.7	1.1	-1.4	-1.3	1.3
Distance moved, locomotor task time 1	0.2	0.2	0.4	-0.3	-0.2	0.4	0.4	-0.6
Vertical activity count, locomotor time 1	1.3	1.3	1.8	-1.4	1.1	-1.1	-1.2	0.9
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.3	0.2	0.3	-0.4	-0.2	0.5
Bouts of movement, locomotor time 2	0.5	0.5	1.2	1.1	-0.6	0.7	0.6	-0.4
Total resting periods, locomotor time 2	0.2	0.2	0.5	0.7	-0.3	0.4	0.3	-0.2
Rest time, locomotor task time 2	2.2	2.5	3.1	-1.6	1.5	-1.8	-1.7	1.3
Distance moved, locomotor task time 2	1.0	1.1	1.6	1.3	-1.1	1.1	1.2	-0.8
Vertical activity count, locomotor time 2	0.1	0.1	0.3	0.5	-0.3	0.2	0.3	-0.1
Light reinforcement 1	0.1	0.1	0.2	0.1	0.5	-0.2	-0.3	0.5
Light reinforcement 2	2.1	2.8	4.0	-1.4	1.7	-1.6	-1.6	2.0
Bone: marrow area	1.4	3.0	7.4	-2.7	1.5	-1.5	-1.5	0.7
Bone: maximum diameter	0.0	0.1	0.3	-0.3	0.2	-0.2	-0.2	0.5
Bone: maximum force	1.6	2.8	3.4	0.9	-1.9	1.7	1.9	-1.8
Bone: maximum moment	1.4	2.4	3.0	0.9	-1.7	1.6	1.7	-1.7
Mean time between licks in bursts	1.6	2.2	2.6	1.2	-1.5	1.5	1.5	-1.6
Mean num. licks in bursts	0.0	0.0	0.0	0.0	0.1	-0.0	-0.1	-0.1
Cd content in liver	2.2	2.4	3.6	-1.0	1.6	-1.3	-1.6	1.9
Co content in liver	0.3	0.3	0.4	0.1	0.6	-0.5	-0.6	0.7
Cu content in liver	0.2	0.3	0.5	0.7	-0.5	0.5	0.5	-0.5
Fe content in liver	0.0	0.0	0.1	0.1	-0.2	0.3	0.2	0.0
K content in liver	1.5	1.5	2.7	0.4	-1.3	1.2	1.2	-1.7
Mg content in liver	0.2	0.2	0.6	-0.5	-0.3	0.1	0.3	-0.8
Mn content in liver	1.1	1.3	1.6	1.2	-1.2	1.2	1.2	-0.7
Na content in liver	0.7	0.7	0.9	0.9	-0.8	0.9	0.9	-0.5
Rb content in liver	1.2	1.5	2.5	-1.6	1.2	-1.3	-1.2	0.7
Se content in liver	0.5	0.7	1.3	-0.5	0.8	-0.8	-0.8	1.2
Sr content in liver	2.9	2.7	4.7	2.2	-1.6	1.7	1.6	-0.8
Zn content in liver	0.9	1.0	1.2	1.1	-1.1	0.9	1.1	-0.8
Bone: minimum diameter	1.2	2.3	5.2	-2.3	1.4	-1.4	-1.4	0.6
Time in familiar zone, hab. session 1	0.4	0.3	0.8	-0.9	0.5	-0.5	-0.5	0.2
Time in novel zone, hab. session 1	0.0	0.0	0.1	0.2	-0.1	0.1	0.1	-0.1
Total zone transitions, hab. session 1	0.5	0.7	0.8	0.8	-0.9	0.8	0.9	-0.8
Total locomotion distance, hab. session 1	0.3	0.4	1.0	-1.0	0.5	-0.7	-0.5	0.2
Locomotion velocity, hab. session 1	0.0	0.1	0.2	-0.4	0.1	-0.2	-0.1	-0.1
Time in familiar zone, hab. session 2	0.4	0.4	0.7	0.3	-0.5	0.8	0.5	-0.7
Time in novel zone, hab. session 2	0.0	0.0	0.1	0.0	0.0	-0.3	-0.0	0.1
Total zone transitions, hab. session 2	1.4	1.8	3.3	0.5	-1.5	1.2	1.5	-1.8
Total locomotion distance, hab. session 2	0.2	0.3	0.8	-0.8	-0.3	0.1	0.3	-0.9
Locomotion velocity, hab. session 2	0.2	0.3	1.2	-1.1	0.1	-0.3	-0.1	-0.5
Novel to familiar place preference ratio	0.1	0.1	0.4	0.6	-0.3	0.4	0.3	0.0
Novelty place preference	0.0	0.0	0.1	0.4	-0.0	0.0	0.0	0.2
Time in novel zone, NPP test	0.0	0.0	0.1	0.3	-0.0	0.1	0.0	0.2
Total zone transitions, NPP test	2.0	2.8	3.2	1.3	-1.8	1.7	1.8	-1.7
Total locomotion distance, NPP test	0.1	0.2	0.5	-0.3	-0.4	0.2	0.4	-0.7
Locomotion velocity, NPP test	0.1	0.1	0.4	-0.1	-0.4	0.2	0.4	-0.6
Intraocular pressure	2.0	2.7	5.3	-0.4	1.6	-1.7	-1.6	2.3
Delta distance traveled before/after self-admin	0.0	0.0	0.0	0.1	-0.0	-0.1	0.1	-0.1
Delta ambulatory time before/after self-admin	0.1	0.1	0.1	0.3	-0.2	0.2	0.3	-0.4
Parametrial fat weight	2.6	5.1	8.5	-2.9	2.3	-2.1	-2.3	1.3
Pavlov. Cond. lever latency	0.2	0.2	0.4	-0.1	0.5	-0.5	-0.5	0.6
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	0.0	-0.3	0.3	0.3	-0.5
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	-0.2	0.4	-0.3	-0.4	0.5
Pavlov. Cond. index score	0.0	0.1	0.1	0.3	-0.2	0.3	0.2	-0.1
Pavlov. Cond. latency score	0.0	0.0	0.1	0.1	-0.2	0.3	0.2	-0.3
Pavlov. Cond. lever contacts	0.0	0.1	0.1	-0.1	-0.2	0.3	0.2	-0.4
Pavlov. Cond. magazine entry number	0.1	0.1	0.4	-0.6	0.1	-0.2	-0.2	-0.2
Pavlov. Cond. intertrial magazine entries	0.9	1.1	1.8	-0.4	1.2	-1.0	-1.1	1.3
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.3	0.5	-0.4	0.5	0.4	-0.3
Pavlov. Cond. response bias	0.0	0.0	0.1	0.3	-0.1	0.1	0.1	0.1
Pavlov. Cond. lever latency	0.1	0.1	0.1	-0.2	0.3	-0.2	-0.3	0.1
Pavlov. Cond. magazine entry latency	2.7	3.1	3.6	1.8	-1.8	1.9	1.8	-1.6
Pavlov. Cond. change in total contacts	0.3	0.4	0.8	0.9	-0.6	0.6	0.6	-0.1
Pavlov. Cond. index score	0.9	1.2	1.4	1.2	-1.1	1.1	1.1	-0.8
Pavlov. Cond. latency score	0.7	0.8	0.9	0.9	-1.0	0.9	1.0	-0.7
Pavlov. Cond. lever contacts	0.1	0.1	0.4	0.6	-0.3	0.3	0.3	0.1
Pavlov. Cond. magazine entry number	4.1	5.0	5.8	-2.4	2.3	-2.3	-2.3	1.8
Pavlov. Cond. intertrial magazine entries	1.0	1.4	1.5	-1.2	1.2	-1.2	-1.2	1.0
Pavlov. Cond. lever-magazine prob. diff.	1.3	1.7	2.0	1.4	-1.4	1.4	1.4	-1.0
Pavlov. Cond. response bias	0.7	1.0	1.6	1.3	-1.0	1.0	1.0	-0.6
Time in closed arm before self-admin	0.1	0.1	0.2	-0.1	0.3	-0.2	-0.2	0.4
Time in closed arm after self-admin	0.1	0.1	0.2	-0.3	-0.0	0.1	0.1	-0.4
Time in open arm before self-admin	0.1	0.2	0.6	-0.3	-0.2	0.0	0.2	-0.8
Time in open arm after self-admin	0.1	0.1	0.2	0.3	0.2	-0.2	-0.3	0.4
Bone: periosteal estimation	0.3	0.6	1.7	-1.3	0.6	-0.6	-0.6	0.4
Bone: periosteal perimeter	0.1	0.1	0.4	-0.6	0.2	-0.3	-0.2	0.2
Bone: post-yield work	0.5	0.7	2.9	-1.7	0.4	-0.7	-0.4	-0.2
Progressive ratio test 1 active lever presses	3.7	3.9	4.1	-1.9	2.0	-2.0	-2.0	2.0
Progressive ratio test 1 breakpoint	3.3	3.5	3.7	-1.7	1.8	-1.9	-1.9	1.9
Progressive ratio test 1 inactive lever presses	1.1	1.2	1.5	-1.0	1.2	-1.1	-1.1	0.9
Progressive ratio test 2 active lever presses	6.9	7.4	7.6	-2.6	2.7	-2.7	-2.8	2.7
Progressive ratio test 2 breakpoint	7.7	8.6	9.1	-2.7	3.0	-3.0	-3.0	3.0
Progressive ratio test 2 inactive lever presses	11.9	13.8	14.7	-3.6	3.8	-3.8	-3.7	3.6
Incentive Sensitization - Responses	1.2	1.3	1.4	-1.1	1.1	-1.1	-1.1	1.2
Incentive Sensitization - Breakpoint	1.7	1.7	1.9	-1.2	1.3	-1.3	-1.3	1.4
Sum of active levers in priming session hrs 5-6	0.6	0.6	2.1	1.5	-0.3	0.4	0.4	0.8
Progressive ratio	1.7	1.9	2.8	0.6	-1.5	1.4	1.5	-1.7
Food seeking constrained by brief footshock	0.5	0.6	0.8	0.6	-0.8	0.9	0.7	-0.9
Seeking ratio, punishment vs. effort	0.6	0.8	1.1	-0.5	1.0	-0.9	-1.0	0.8
Retroperitoneal fat weight	5.8	19.1	23.8	-4.9	4.5	-4.5	-4.4	3.5
Reaction time number correct	0.3	0.5	0.8	0.9	-0.8	0.5	0.6	-0.4
Reaction time mean minus median	1.2	1.6	1.9	1.4	-1.4	1.2	1.4	-0.9
Reaction time mean minus median AUC	0.7	0.9	1.5	1.2	-1.1	0.9	1.0	-0.5
Reaction time num false alarms	0.1	0.1	0.3	-0.1	-0.1	0.0	0.2	-0.6
Reaction time num false alarms AUC	0.4	0.6	1.2	0.5	-0.7	0.7	0.8	-1.1
Reaction time trials correct on left	0.3	0.5	0.8	0.9	-0.8	0.5	0.6	-0.4
Reaction time trials on left	0.4	0.6	1.0	1.0	-0.9	0.6	0.7	-0.5
Reaction time mean	0.1	0.2	0.4	0.0	0.3	-0.5	-0.3	0.6
Reaction time mean AUC	0.2	0.2	0.5	-0.1	0.4	-0.6	-0.3	0.7
Median of all reaction times	0.3	0.4	0.7	-0.4	0.6	-0.8	-0.6	0.8
Reaction time omissions	0.8	1.1	1.5	1.2	-1.2	0.9	1.2	-0.7
Reaction time false alarm rate	0.1	0.1	0.3	-0.3	0.0	0.1	0.1	-0.6
Reaction time premature initiation rate	4.6	6.2	6.8	2.2	-2.6	2.5	2.6	-2.5
Reaction time premature initiations	6.1	8.7	9.8	3.0	-3.1	2.9	3.0	-2.6
Std. dev. reaction times	0.2	0.2	0.5	0.7	-0.5	0.3	0.5	-0.0
Reaction time trials completed	0.4	0.6	1.0	1.0	-0.9	0.6	0.7	-0.5
Reaction time trials AUC	0.3	0.4	0.5	0.7	-0.7	0.5	0.6	-0.5
Run reversals in cocaine runway, females	1.7	1.6	4.3	-0.1	-1.1	1.2	1.1	-2.1
Run reversals in cocaine runway, males	0.2	0.2	0.4	-0.0	0.4	-0.4	-0.4	0.6
Latency to leave start box in cocaine runway	0.2	0.2	0.8	-0.9	0.4	-0.2	-0.3	-0.1
Latency to leave start box in cocaine runway, F	0.0	0.0	0.1	-0.2	0.1	0.1	-0.1	-0.0
Latency to leave start box in cocaine runway, M	0.1	0.1	0.5	-0.7	0.3	-0.2	-0.1	-0.1
Std. dev. time between licks in bursts	0.2	0.3	0.5	0.2	-0.5	0.4	0.5	-0.7
Total sessions with >9 infusions	2.0	2.2	5.1	-2.3	1.3	-1.4	-1.4	0.6
Short access day 1 total inactive lever presses	4.0	4.4	5.1	-2.3	2.0	-2.2	-2.3	1.7
Short access day 10 total inactive lever presses	2.4	2.6	3.3	-1.6	1.8	-1.7	-1.7	1.1
Short access day 1 total infusions	3.1	3.3	6.5	-2.5	1.7	-1.7	-1.7	1.0
Short access day 10 total infusions	2.3	2.6	6.8	-2.6	1.4	-1.4	-1.4	0.6
Short access total infusions	1.7	1.9	5.0	-2.2	1.2	-1.2	-1.2	0.5
Short access day 1 locomotion	2.5	2.7	6.1	-2.5	1.6	-1.5	-1.5	0.7
Short access day 10 total locomotion	1.8	2.0	4.1	-2.0	1.3	-1.4	-1.4	0.6
Short access total locomotion	1.5	1.6	3.9	-2.0	1.1	-1.1	-1.2	0.3
One hour access (0.3 mA shock)	12.5	14.6	15.4	-3.7	3.9	-3.9	-3.8	3.7
Compulsive drug intake	5.0	5.1	6.7	2.6	-2.1	2.2	2.2	-2.1
One hour access (shock baseline)	14.0	16.2	17.5	-3.9	4.0	-4.0	-4.0	4.2
Social response proportion	0.5	0.5	0.7	0.8	-0.7	0.8	0.8	-0.5
Social responses	0.3	0.4	0.8	0.9	-0.6	0.7	0.6	-0.4
Social time	0.6	0.7	1.0	1.0	-1.0	0.7	0.9	-0.6
Soleus weight	3.5	10.3	11.3	-3.4	3.3	-3.3	-3.4	2.6
Bone: stiffness	1.1	1.7	2.1	0.9	-1.4	1.3	1.5	-1.3
Tibialis anterior weight	9.1	31.3	34.5	5.6	-5.9	5.9	5.8	-4.7
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.5	-0.1	-0.5	0.7	0.5	-0.7
Time to tail flick, vehicle, after self-admin	2.6	2.7	4.7	0.7	-1.6	1.8	1.6	-2.2
Time to tail flick, test, before self-admin	0.6	0.6	2.1	-1.5	0.5	-0.5	-0.5	-0.3
Time to tail flick, test, after self-admin	0.0	0.0	0.0	0.1	-0.2	0.2	0.2	-0.1
Delta time to tail flick, vehicle, before/after SA	1.0	1.0	1.6	0.6	-1.0	1.0	1.0	-1.3
Delta time to tail flick, test, before/after SA	1.3	1.2	3.4	1.8	-0.9	0.9	0.9	0.1
Tibia length	0.2	0.5	1.3	1.2	-0.6	0.7	0.6	0.3
Ambulatory time before self-admin	0.1	0.1	0.2	0.3	-0.0	0.1	0.0	0.5
Ambulatory time after self-admin	0.4	0.5	0.7	-0.4	0.7	-0.8	-0.7	0.9
Bone: tissue strength	0.1	0.0	0.1	-0.1	0.2	-0.3	-0.2	0.3
Total heroin consumption	5.3	6.2	7.1	2.6	-2.6	2.7	2.6	-2.0
Bone: trabecular number	0.0	0.1	0.1	-0.1	-0.2	0.3	0.2	-0.3
Bone: trabecular spacing	0.0	0.0	0.0	0.1	-0.0	0.0	0.0	-0.2
Bone: trabecular thickness	0.8	0.9	1.2	-1.0	1.0	-1.1	-1.0	0.7
Bone: trabecular tissue density	3.5	5.0	5.7	-1.9	2.4	-2.2	-2.4	2.2
Water consumed over 24 hours	1.1	1.4	2.7	1.6	-1.1	1.1	1.1	-0.7
Number of responses in last shaping day	0.8	0.9	1.2	-0.7	1.0	-1.0	-1.1	0.8