Ppp2r5b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	Ppp2r5b	0.06	0.03	5.1e-10	0.03	0.06	0.05	0.05	3.2e-05	5.1e-09	1.9e-08	5.8e-08
2	Brain	isoform ratio	NM_181379.3	0.08	0.06	9.3e-06	0.06	0.05	0.06	0.06	2.5e-06	1.2e-05	5.9e-06	3.6e-06
3	Brain	isoform ratio	XM_039079691.2	0.07	0.05	1.6e-05	0.06	0.05	0.05	0.05	4.6e-06	3.2e-05	1.6e-05	1.3e-05
4	Brain	gene expression	Ppp2r5b	0.1	0.06	9.1e-09	0.09	0.06	0.08	0.08	1.1e-08	1.1e-06	1.1e-07	4.5e-08
5	Adipose	gene expression	Ppp2r5b	0.2	0.08	5.6e-17	0.11	0.11	0.12	0.1	8.8e-12	4.0e-12	5.8e-13	1.1e-11
6	Adipose	mRNA stability	Ppp2r5b	0.05	0.03	4.3e-04	0.01	0.02	0.01	0.01	2.7e-02	6.0e-03	3.1e-02	4.4e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.2	0.4	1.1	0.1	-0.6	0.6	0.7	0.3	-1.1
Area under the delay curve	0.1	0.2	0.5	0.3	-0.2	0.2	0.4	0.5	-0.7
BMI with tail	1.2	4.2	9.7	-0.0	-2.2	2.2	2.1	1.2	-3.1
BMI without tail	0.6	3.2	6.5	-0.4	-1.8	1.8	1.8	1.7	-2.5
Body weight	2.5	10.8	14.6	-2.2	-3.6	3.6	3.5	2.6	-3.8
Weight adjusted by age	0.4	1.3	2.1	-1.5	-1.2	1.2	1.2	0.7	-0.8
Bone surface	1.8	3.6	4.9	-1.6	-2.2	2.2	2.2	0.8	-2.0
Bone volume	0.3	0.6	0.9	-0.5	-0.9	0.9	1.0	-0.1	-0.9
Breakpoint value in progressive ratio session	1.3	2.3	2.8	-1.7	-1.6	1.6	1.6	1.0	-1.4
Number of licking bursts	0.0	0.1	0.2	-0.5	-0.4	0.4	0.4	0.2	-0.2
Context. condit. distance diff. score	1.1	1.3	2.1	1.4	1.3	-1.3	-1.1	-0.7	0.7
Locomotion velocity, session 1	0.2	0.3	0.5	-0.3	-0.5	0.5	0.5	0.7	-0.6
Locomotion distance, session 1	0.8	1.0	2.1	-0.1	-1.0	1.0	0.9	1.0	-1.4
Locomotion velocity, session 2	2.4	2.8	3.6	-1.2	-1.8	1.8	1.8	1.4	-1.9
Locomotion distance, session 2	1.0	1.4	2.5	-0.5	-1.2	1.2	1.1	1.3	-1.6
Locomotion velocity, session 3	0.2	0.3	1.3	1.1	0.2	-0.2	-0.4	-0.2	-0.4
Locomotion distance, session 3	0.0	0.0	0.0	0.2	0.0	-0.0	-0.1	0.0	-0.1
Stereotopy head waving bouts, day 3	0.4	0.5	2.0	1.4	0.4	-0.4	-0.6	-0.2	-0.3
Stereotopy head waving duration, day 3	0.5	0.7	1.6	1.3	0.8	-0.8	-0.8	-0.6	0.3
Locomotion velocity, session 7	0.5	0.6	2.0	1.4	0.6	-0.6	-0.8	-0.5	-0.1
Locomotion distance, session 7	0.2	0.2	0.7	0.5	-0.3	0.3	0.1	0.6	-0.8
Stereotopy head waving bouts, day 7	0.3	0.4	0.7	0.6	0.6	-0.6	-0.4	-0.9	0.4
Stereotopy head waving duration, day 7	0.1	0.1	0.3	-0.3	-0.4	0.4	0.5	-0.0	-0.4
Locomotion velocity, session 8	1.6	2.0	2.4	-1.2	-1.4	1.4	1.5	1.5	-1.4
Locomotion distance, session 8	0.2	0.3	1.2	1.1	0.5	-0.5	-0.5	-0.3	-0.2
Degree of sensitization distance	0.1	0.1	0.4	0.5	-0.2	0.2	0.0	0.2	-0.7
Degree of sensitization stereotypy	0.0	0.0	0.2	-0.1	-0.1	0.1	0.2	-0.4	0.1
Conditioned locomotion	1.6	1.8	2.4	-1.3	-1.5	1.5	1.3	1.2	-1.3
Cocaine response after cond. corrected	0.3	0.5	1.2	1.1	0.7	-0.7	-0.9	-0.2	0.3
Cocaine response after cond. not corrected	0.3	0.4	1.0	1.0	0.6	-0.6	-0.7	-0.2	0.2
Cocaine response before conditioning	0.2	0.2	0.5	-0.7	-0.4	0.4	0.7	0.0	-0.2
Saline control response	4.4	6.1	7.2	-2.3	-2.6	2.6	2.7	2.2	-2.4
Bone: connectivity density	1.5	2.4	3.4	-1.0	-1.7	1.7	1.8	1.0	-1.8
Bone: cortical apparent density	0.1	0.2	0.5	-0.7	-0.2	0.2	0.2	0.5	0.0
Bone: cortical area	0.3	0.4	0.6	-0.7	-0.7	0.7	0.8	0.2	-0.5
Bone: cortical porosity	0.1	0.1	0.2	-0.2	-0.5	0.5	0.3	0.3	-0.4
Bone: cortical porosity	0.6	0.6	0.8	-0.6	-0.9	0.9	0.8	0.7	-0.9
Bone: cortical thickness	3.3	5.4	7.4	-2.7	-2.4	2.4	2.4	2.3	-1.7
Bone: cortical thickness	1.4	1.7	2.7	-1.3	-1.2	1.2	1.2	1.7	-1.1
Bone: cortical tissue density	0.2	0.3	0.9	-0.9	-0.4	0.4	0.4	0.7	-0.1
Condit. Reinf. active minus inactive responses	0.2	0.2	0.4	-0.3	-0.5	0.5	0.4	0.6	-0.6
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.1	-0.4	-0.2	0.2	0.1	0.4	-0.1
Condit. Reinf. active responses	0.0	0.0	0.1	0.3	-0.0	0.0	-0.1	-0.1	-0.2
Condit. Reinf. inactive responses	0.3	0.4	1.1	1.0	0.5	-0.5	-0.6	-0.8	0.1
Incentive salience index mean	0.3	0.4	0.9	-0.1	-0.6	0.6	0.5	0.6	-0.9
Condit. Reinf. lever presses	0.1	0.2	0.4	-0.0	-0.4	0.4	0.4	0.0	-0.7
Condit. Reinf. active minus inactive responses	0.3	0.5	0.9	0.5	0.7	-0.7	-0.7	-1.0	0.7
Condit. Reinf. active-inactive response ratio	1.5	2.4	3.8	1.5	1.4	-1.4	-1.5	-2.0	1.3
Condit. Reinf. active responses	0.0	0.0	0.0	-0.1	-0.0	0.0	-0.0	-0.2	0.1
Condit. Reinf. inactive responses	0.8	1.2	1.7	-1.0	-1.0	1.0	1.1	1.3	-1.1
Condit. Reinf. lever presses	0.4	0.6	1.0	-1.0	-0.9	0.9	0.9	0.1	-0.6
Condit. Reinf. lever reinforcers received	0.0	0.1	0.2	-0.4	-0.3	0.3	0.2	-0.0	-0.1
Conditioned reinforcement - actives	0.3	1.1	3.0	0.2	0.6	-0.6	-0.6	-1.7	1.4
Conditioned reinforcement - inactives	2.5	6.8	9.2	1.9	2.5	-2.5	-2.6	-3.0	3.0
Conditioned locomotion	8.3	12.4	14.6	2.9	3.6	-3.6	-3.6	-3.5	3.8
Patch foraging indifference point 0 sec	0.0	0.0	0.0	0.2	0.2	-0.2	-0.0	-0.1	0.1
Patch foraging indifference point AUC	0.6	1.3	3.1	-1.8	-1.2	1.2	1.2	0.6	-0.6
Delay disc. indifference point, 0s delay	0.2	0.2	0.6	0.8	0.1	-0.1	0.1	0.4	-0.7
Delay disc. indifference point, 16s delay	0.7	1.0	1.3	1.0	1.0	-1.0	-1.1	-0.9	0.8
Delay disc. indifference point, 2s delay	0.1	0.1	0.4	0.6	0.4	-0.4	-0.1	-0.4	0.0
Delay disc. indifference point, 24s delay	0.1	0.1	0.4	-0.3	-0.2	0.2	0.3	0.6	-0.3
Delay disc. indifference point, 4s delay	0.3	0.3	0.9	0.3	-0.3	0.3	0.5	0.8	-0.9
Delay disc. indifference point, 8s delay	0.2	0.3	0.7	0.0	-0.4	0.4	0.6	0.9	-0.8
Indifference point function ln k	1.9	5.7	9.5	3.1	2.5	-2.5	-2.7	-1.4	1.6
Indifference point function log k	1.9	5.7	9.5	3.1	2.5	-2.5	-2.7	-1.4	1.6
Patch foraging total patch changes 0 sec	0.0	0.0	0.1	-0.1	-0.1	0.1	0.3	0.3	-0.1
Patch foraging total patch changes 12 sec	3.3	4.4	5.5	-2.2	-2.2	2.2	2.3	1.8	-1.9
Patch foraging total patch changes 18 sec	0.1	0.3	0.5	-0.6	-0.5	0.5	0.7	0.3	-0.5
Patch foraging total patch changes 24 sec	0.7	2.3	3.6	-1.9	-1.5	1.5	1.7	1.2	-1.1
Patch foraging total patch changes 6 sec	1.0	1.7	2.1	-1.0	-1.3	1.3	1.4	1.3	-1.4
Patch foraging time to switch 0 sec	0.3	1.1	1.8	-0.3	-1.2	1.2	1.3	0.4	-1.4
Patch foraging water rate 0 sec	1.2	4.5	5.9	1.4	2.3	-2.3	-2.4	-1.6	2.4
Patch foraging water rate 12 sec	1.5	6.0	7.9	2.1	2.7	-2.7	-2.8	-1.4	2.6
Patch foraging water rate 18 sec	0.7	1.5	2.0	1.4	1.4	-1.4	-1.4	-0.6	1.0
Patch foraging water rate 24 sec	2.2	3.2	4.3	1.6	1.9	-1.9	-2.1	-1.3	1.8
Patch foraging water rate 6 sec	1.5	2.3	3.4	1.4	1.7	-1.7	-1.8	-0.7	1.4
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.4	0.6	0.3	-0.3	-0.4	-0.0	-0.0
Distance traveled before self-admin	0.1	0.1	0.2	-0.3	-0.4	0.4	0.4	-0.3	-0.2
Distance traveled after self-admin	0.1	0.1	0.4	-0.6	-0.3	0.3	0.3	0.1	0.0
Extensor digitorum longus weight	6.6	26.5	30.8	-4.7	-5.5	5.5	5.5	4.4	-5.1
Bone: elastic displacement	0.1	0.1	0.2	0.1	0.4	-0.4	-0.4	0.3	0.4
Bone: elastic work	2.0	2.7	3.7	-1.5	-1.6	1.6	1.6	1.9	-1.6
Bone: endosteal estimation	1.0	2.4	5.6	2.4	1.4	-1.4	-1.3	-1.7	0.5
Bone: endosteal perimeter	1.8	4.4	7.1	2.7	2.0	-2.0	-2.0	-2.5	1.3
Epididymis fat weight	2.8	14.1	16.0	3.7	3.8	-3.8	-3.9	-4.0	3.5
Delta time in closed arm before/after self-admin	1.7	1.6	3.1	-0.6	-1.1	1.1	1.2	1.8	-1.5
Delta time in open arm before/after self-admin	0.2	0.3	0.8	-0.3	0.3	-0.3	-0.2	-0.9	0.8
Diff in mean of infusions in LGA sessions	0.4	0.7	0.9	-1.0	-0.8	0.8	0.8	0.7	-0.7
Delay discount exponential model param	0.1	0.2	0.5	-0.1	0.3	-0.3	-0.4	-0.6	0.7
Extinction: sum of active levers before priming	1.2	1.9	2.4	-1.1	-1.5	1.5	1.5	1.1	-1.5
Active lever presses in extinction session 6	1.5	1.5	2.2	-1.5	-1.4	1.4	1.4	0.4	-0.9
Bone: final force	1.5	2.5	3.2	-1.4	-1.8	1.8	1.7	1.0	-1.6
Bone: final moment	1.5	2.4	3.1	-1.4	-1.8	1.8	1.7	1.0	-1.6
Food consumed during 24 hour testing period	0.1	0.2	0.5	-0.5	0.2	-0.2	-0.2	-0.4	0.7
Glucose	2.0	3.1	6.9	2.6	1.8	-1.8	-1.8	-1.4	0.8
Heart weight	0.5	0.8	3.5	1.9	0.6	-0.6	-0.4	0.0	-0.8
Delay discount hyperbolic model param	0.1	0.2	0.4	-0.2	0.2	-0.2	-0.4	-0.5	0.7
Intermittent access intake day 1-15 change	0.6	3.4	4.7	1.1	1.8	-1.8	-1.8	-2.1	2.2
Intermittent access intake escalation	0.6	3.2	4.7	1.0	1.8	-1.8	-1.7	-2.1	2.2
Intermittent access intake escalation 2	1.7	2.8	4.2	0.9	1.7	-1.7	-1.6	-2.0	2.1
Intermitt. access day 1 inactive lever presses	0.0	0.2	0.4	0.2	0.5	-0.5	-0.5	-0.4	0.6
Intermitt. access day 15 inactive lever presses	0.8	4.4	5.8	1.9	2.0	-2.0	-2.0	-2.4	2.2
Intermitt. access escalation Index	0.8	2.5	3.4	1.9	1.8	-1.8	-1.8	-1.0	1.2
Intermittent access day 1 total infusions	1.8	5.4	9.1	3.0	2.1	-2.1	-2.2	-2.6	1.6
Intermittent access day 15 total infusions	5.0	12.2	16.2	3.3	3.4	-3.4	-3.4	-4.0	3.4
Intermittent access terminal intake (last 3 days)	6.3	11.1	16.1	3.3	3.2	-3.2	-3.2	-4.0	3.1
Intermittent access total infusions	6.7	7.9	11.0	3.1	2.7	-2.7	-2.7	-3.3	2.4
Intermittent access day 1 locomotion	2.0	3.8	5.8	2.4	1.8	-1.8	-1.9	-2.1	1.4
Intermittent access day 15 total locomotion	2.9	11.1	16.0	3.0	3.2	-3.2	-3.2	-4.0	3.3
Intermittent access total locomotion	12.4	14.8	20.7	3.9	3.7	-3.7	-3.7	-4.5	3.5
Intermittent access standard deviation	0.5	2.8	3.4	1.2	1.7	-1.7	-1.6	-1.8	1.8
Left kidney weight	0.4	3.1	4.5	2.1	1.9	-1.9	-1.5	-1.8	1.3
Right kidney weight	0.2	1.7	2.1	1.3	1.3	-1.3	-1.2	-1.5	1.3
Cocaine induced anxiety	0.0	0.1	0.2	-0.1	0.0	-0.0	-0.0	-0.5	0.3
Post-drug Anxiety	0.3	0.4	0.5	-0.7	-0.7	0.7	0.7	0.3	-0.5
Baseline Anxiety	0.6	1.0	1.7	-0.9	-0.9	0.9	0.9	1.3	-1.1
Tail length	0.6	3.2	4.4	-2.1	-1.7	1.7	1.8	2.0	-1.4
Length with tail	2.3	10.0	11.0	-3.2	-3.3	3.3	3.2	3.0	-2.8
Length without tail	1.6	8.2	9.3	-2.9	-3.0	3.0	2.9	2.8	-2.5
Times rat made contact with spout	0.9	1.1	1.5	-0.9	-1.0	1.0	1.0	1.2	-1.0
Lifetime Intake	4.2	5.2	7.3	2.7	2.1	-2.1	-2.2	-2.6	1.8
Liver weight, left	0.3	0.6	1.1	1.0	0.8	-0.8	-0.8	-0.5	0.5
Liver weight, right	0.8	1.3	2.9	1.7	1.3	-1.3	-1.2	-0.5	0.5
Locomotor activity	0.6	1.0	1.5	1.0	1.2	-1.2	-1.2	-0.3	0.9
Locomotor testing distance	0.4	1.0	1.6	1.0	1.2	-1.2	-1.2	-0.1	0.9
Locomotor testing rearing	0.3	1.0	1.4	1.0	1.2	-1.2	-1.1	-0.2	0.8
Locomotion in novel chamber	5.8	7.8	9.0	2.7	2.8	-2.8	-3.0	-2.8	2.7
Locomotion in novel chamber post-restriction	1.8	5.5	6.0	2.2	2.4	-2.4	-2.3	-2.3	2.3
Fecal boli incidents, locomotor time 1	0.2	0.5	1.2	0.2	0.6	-0.6	-0.4	-1.1	0.8
Change in fecal boli incidents, locomotor task	0.4	0.4	0.9	0.2	-0.5	0.5	0.4	0.9	-0.9
Time >=10cm from walls, locomotor time 1	2.0	2.4	4.2	1.9	1.3	-1.3	-1.4	-2.0	1.1
Bouts of movement, locomotor time 1	0.9	1.2	3.5	-1.9	-1.0	1.0	1.0	0.9	-0.3
Total resting periods, locomotor time 1	0.5	0.5	1.9	-1.4	-0.6	0.6	0.7	0.4	0.0
Rest time, locomotor task time 1	1.3	2.1	2.5	1.1	1.5	-1.5	-1.5	-1.4	1.6
Distance moved, locomotor task time 1	0.1	0.2	0.6	0.1	-0.4	0.4	0.4	0.4	-0.8
Vertical activity count, locomotor time 1	0.1	0.8	1.1	1.0	1.0	-1.0	-0.9	-0.7	0.7
Time >=10cm from walls, locomotor time 2	0.1	0.2	0.6	-0.0	0.2	-0.2	-0.5	-0.8	0.6
Bouts of movement, locomotor time 2	0.1	0.4	0.8	-0.9	-0.6	0.6	0.6	0.6	-0.4
Total resting periods, locomotor time 2	0.0	0.1	0.2	-0.5	-0.2	0.2	0.3	0.3	-0.2
Rest time, locomotor task time 2	1.6	2.7	3.4	1.8	1.7	-1.7	-1.7	-1.4	1.3
Distance moved, locomotor task time 2	1.1	1.4	2.1	-1.5	-1.3	1.3	1.1	1.0	-0.9
Vertical activity count, locomotor time 2	0.1	0.2	0.5	-0.7	-0.3	0.3	0.2	0.6	-0.1
Light reinforcement 1	0.0	0.0	0.1	-0.1	0.2	-0.2	0.0	-0.0	0.4
Light reinforcement 2	1.2	2.7	4.3	1.2	1.6	-1.6	-1.5	-2.1	1.9
Bone: marrow area	1.0	2.5	6.0	2.4	1.4	-1.4	-1.4	-1.7	0.5
Bone: maximum diameter	0.1	0.2	0.9	0.1	0.1	-0.1	-0.1	-1.0	0.3
Bone: maximum force	1.3	2.6	3.5	-1.1	-1.9	1.9	1.8	0.8	-1.8
Bone: maximum moment	1.3	2.5	3.3	-1.1	-1.8	1.8	1.7	0.8	-1.8
Mean time between licks in bursts	0.3	1.8	2.8	-1.0	-1.3	1.3	1.3	1.7	-1.4
Mean num. licks in bursts	0.0	0.0	0.1	0.1	0.1	-0.1	-0.1	0.3	-0.0
Cd content in liver	2.6	2.9	3.8	1.2	1.8	-1.8	-1.5	-1.9	1.8
Co content in liver	0.2	0.2	0.4	-0.0	0.6	-0.6	-0.5	0.4	0.7
Cu content in liver	0.0	0.0	0.0	0.2	0.1	-0.1	-0.1	0.1	0.0
Fe content in liver	0.1	0.1	0.2	-0.4	-0.4	0.4	0.5	0.2	-0.3
K content in liver	0.9	0.9	1.8	-0.2	-0.9	0.9	1.0	0.9	-1.3
Mg content in liver	0.1	0.1	0.5	0.7	0.2	-0.2	-0.2	0.3	-0.3
Mn content in liver	1.7	1.9	2.5	-1.6	-1.6	1.6	1.5	0.7	-1.0
Na content in liver	0.4	0.4	0.7	-0.8	-0.6	0.6	0.8	0.6	-0.4
Rb content in liver	0.9	1.1	1.9	1.4	1.1	-1.1	-1.3	-0.4	0.6
Se content in liver	0.7	0.8	1.6	0.6	0.8	-0.8	-0.8	-1.2	1.1
Sr content in liver	2.2	1.9	3.5	-1.9	-1.4	1.4	1.5	0.9	-0.8
Zn content in liver	0.4	0.5	0.6	-0.7	-0.7	0.7	0.8	0.8	-0.7
Bone: minimum diameter	1.0	2.0	4.7	2.2	1.3	-1.3	-1.3	-1.5	0.5
Time in familiar zone, hab. session 1	0.3	0.3	0.7	0.8	0.6	-0.6	-0.5	-0.4	0.2
Time in novel zone, hab. session 1	0.1	0.1	0.2	-0.2	-0.2	0.2	0.1	0.5	-0.0
Total zone transitions, hab. session 1	0.4	0.6	0.7	-0.7	-0.8	0.8	0.7	0.7	-0.8
Total locomotion distance, hab. session 1	0.3	0.4	1.1	1.0	0.6	-0.6	-0.8	-0.5	0.2
Locomotion velocity, hab. session 1	0.0	0.1	0.3	0.5	0.1	-0.1	-0.3	-0.1	-0.1
Time in familiar zone, hab. session 2	0.4	0.5	0.9	-0.4	-0.5	0.5	0.8	0.9	-0.7
Time in novel zone, hab. session 2	0.0	0.0	0.1	0.1	0.1	-0.1	-0.3	-0.3	0.1
Total zone transitions, hab. session 2	1.3	1.7	3.3	-0.4	-1.4	1.4	1.3	1.2	-1.8
Total locomotion distance, hab. session 2	0.2	0.3	0.8	0.8	-0.2	0.2	0.1	0.3	-0.9
Locomotion velocity, hab. session 2	0.2	0.3	1.1	1.1	0.1	-0.1	-0.3	-0.1	-0.6
Novel to familiar place preference ratio	0.1	0.1	0.3	-0.6	-0.3	0.3	0.3	-0.4	0.0
Novelty place preference	0.1	0.1	0.3	-0.3	0.0	-0.0	-0.0	-0.5	0.3
Time in novel zone, NPP test	0.0	0.0	0.2	-0.3	-0.0	0.0	-0.0	-0.4	0.2
Total zone transitions, NPP test	1.7	2.5	3.0	-1.2	-1.7	1.7	1.7	1.3	-1.7
Total locomotion distance, NPP test	0.1	0.2	0.6	0.3	-0.3	0.3	0.2	0.4	-0.7
Locomotion velocity, NPP test	0.1	0.1	0.4	0.2	-0.3	0.3	0.2	0.3	-0.6
Intraocular pressure	1.9	3.2	5.3	0.7	1.8	-1.8	-1.7	-2.0	2.3
Delta distance traveled before/after self-admin	0.1	0.1	0.6	-0.3	-0.1	0.1	0.1	0.8	-0.1
Delta ambulatory time before/after self-admin	0.2	0.3	0.9	-0.5	-0.4	0.4	0.4	0.9	-0.3
Parametrial fat weight	3.9	9.3	11.7	3.4	3.1	-3.1	-3.1	-3.0	2.4
Pavlov. Cond. lever latency	0.2	0.3	0.5	0.2	0.5	-0.5	-0.6	-0.4	0.7
Pavlov. Cond. magazine entry latency	0.1	0.1	0.3	0.0	-0.3	0.3	0.4	0.1	-0.5
Pavlov. Cond. change in total contacts	0.1	0.1	0.4	0.2	0.3	-0.3	-0.2	-0.7	0.3
Pavlov. Cond. index score	0.1	0.1	0.2	-0.3	-0.3	0.3	0.4	0.0	-0.2
Pavlov. Cond. latency score	0.1	0.1	0.1	-0.1	-0.3	0.3	0.4	0.1	-0.4
Pavlov. Cond. lever contacts	0.1	0.1	0.4	0.1	-0.3	0.3	0.4	0.3	-0.6
Pavlov. Cond. magazine entry number	0.1	0.1	0.3	0.6	0.2	-0.2	-0.4	0.0	-0.1
Pavlov. Cond. intertrial magazine entries	0.9	1.1	1.7	0.5	1.1	-1.1	-1.1	-1.0	1.3
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.3	-0.4	-0.4	0.4	0.5	0.1	-0.4
Pavlov. Cond. response bias	0.0	0.1	0.1	-0.4	-0.2	0.2	0.3	-0.0	-0.0
Pavlov. Cond. lever latency	0.1	0.1	0.2	0.5	0.3	-0.3	-0.3	0.3	0.0
Pavlov. Cond. magazine entry latency	2.5	3.5	4.7	-1.9	-2.0	2.0	2.2	1.4	-1.8
Pavlov. Cond. change in total contacts	0.1	0.3	0.7	-0.8	-0.6	0.6	0.6	-0.3	-0.2
Pavlov. Cond. index score	0.7	1.1	1.5	-1.2	-1.2	1.2	1.2	0.4	-0.9
Pavlov. Cond. latency score	0.5	0.8	1.1	-1.0	-1.0	1.0	1.0	0.2	-0.7
Pavlov. Cond. lever contacts	0.1	0.1	0.3	-0.5	-0.4	0.4	0.3	-0.2	-0.1
Pavlov. Cond. magazine entry number	3.8	4.9	6.2	2.5	2.4	-2.4	-2.4	-1.5	1.9
Pavlov. Cond. intertrial magazine entries	0.6	1.4	1.6	1.1	1.2	-1.2	-1.3	-1.1	1.1
Pavlov. Cond. lever-magazine prob. diff.	1.0	1.5	2.0	-1.4	-1.4	1.4	1.4	0.5	-1.0
Pavlov. Cond. response bias	0.8	1.1	1.4	-1.2	-1.1	1.1	1.2	0.4	-0.8
Time in closed arm before self-admin	0.7	1.2	2.0	0.9	1.0	-1.0	-1.0	-1.4	1.0
Time in closed arm after self-admin	0.1	0.1	0.5	0.7	0.3	-0.3	-0.4	-0.0	0.0
Time in open arm before self-admin	0.8	1.0	3.3	-0.3	-0.7	0.7	0.7	1.8	-1.2
Time in open arm after self-admin	0.3	0.4	0.6	-0.7	-0.5	0.5	0.5	0.8	-0.5
Bone: periosteal estimation	0.2	0.5	1.2	1.0	0.5	-0.5	-0.4	-1.1	0.1
Bone: periosteal perimeter	0.1	0.1	0.5	0.5	0.0	-0.0	-0.1	-0.7	-0.1
Bone: post-yield work	0.4	0.7	2.2	1.5	0.1	-0.1	-0.4	-1.2	-0.6
Progressive ratio test 1 active lever presses	0.6	1.0	1.8	0.9	0.9	-0.9	-0.9	-1.3	1.0
Progressive ratio test 1 breakpoint	0.6	1.0	1.9	0.8	0.9	-0.9	-0.9	-1.4	1.0
Progressive ratio test 1 inactive lever presses	0.1	0.3	0.6	0.3	0.4	-0.4	-0.5	-0.7	0.8
Progressive ratio test 2 active lever presses	4.2	5.9	8.5	2.1	2.3	-2.3	-2.3	-2.9	2.5
Progressive ratio test 2 breakpoint	4.6	5.9	8.5	2.1	2.3	-2.3	-2.3	-2.9	2.5
Progressive ratio test 2 inactive lever presses	4.7	14.9	17.5	3.5	3.8	-3.8	-3.9	-4.2	3.9
Incentive Sensitization - Responses	0.1	0.4	1.0	0.7	0.5	-0.5	-0.5	-1.0	0.4
Incentive Sensitization - Breakpoint	0.3	0.7	1.4	0.9	0.7	-0.7	-0.7	-1.2	0.6
Sum of active levers in priming session hrs 5-6	0.6	0.6	1.5	-1.2	-0.1	0.1	0.2	-0.9	1.1
Progressive ratio	0.3	0.8	1.6	0.0	-1.0	1.0	0.9	0.3	-1.3
Food seeking constrained by brief footshock	0.1	0.2	0.3	-0.2	-0.4	0.4	0.4	0.6	-0.6
Seeking ratio, punishment vs. effort	0.2	0.5	0.8	0.3	0.9	-0.9	-0.8	0.2	0.7
Retroperitoneal fat weight	7.4	33.1	39.9	6.3	6.1	-6.1	-6.1	-4.9	4.9
Reaction time number correct	0.1	0.3	0.7	-0.8	-0.6	0.6	0.4	0.4	-0.3
Reaction time mean minus median	0.3	1.8	2.6	-1.6	-1.6	1.6	1.3	0.5	-1.0
Reaction time mean minus median AUC	0.2	1.0	1.9	-1.4	-1.2	1.2	0.9	0.4	-0.6
Reaction time num false alarms	0.1	0.2	0.9	0.2	-0.1	0.1	0.0	1.0	-0.5
Reaction time num false alarms AUC	0.3	0.7	2.0	-0.4	-0.7	0.7	0.6	1.4	-1.0
Reaction time trials correct on left	0.1	0.3	0.7	-0.8	-0.6	0.6	0.4	0.4	-0.3
Reaction time trials on left	0.1	0.4	0.9	-1.0	-0.7	0.7	0.4	0.5	-0.4
Reaction time mean	0.1	0.1	0.4	-0.1	0.1	-0.1	-0.4	-0.6	0.5
Reaction time mean AUC	0.1	0.2	0.5	0.1	0.2	-0.2	-0.5	-0.7	0.6
Median of all reaction times	0.3	0.5	0.7	0.5	0.6	-0.6	-0.9	-0.9	0.8
Reaction time omissions	0.9	1.4	2.1	-1.4	-1.4	1.4	1.0	0.8	-0.9
Reaction time false alarm rate	0.1	0.2	0.7	0.4	-0.0	0.0	0.1	0.8	-0.5
Reaction time premature initiation rate	4.4	6.8	8.0	-2.3	-2.7	2.7	2.5	2.8	-2.6
Reaction time premature initiations	2.9	8.8	9.8	-3.0	-3.1	3.1	2.8	3.1	-2.6
Std. dev. reaction times	0.1	0.3	0.8	-0.9	-0.7	0.7	0.4	0.0	-0.2
Reaction time trials completed	0.1	0.4	0.9	-1.0	-0.7	0.7	0.4	0.5	-0.4
Reaction time trials AUC	0.1	0.3	0.6	-0.7	-0.6	0.6	0.3	0.5	-0.4
Run reversals in cocaine runway, females	1.3	1.5	3.5	0.1	-0.9	0.9	1.1	1.5	-1.9
Run reversals in cocaine runway, males	0.2	0.2	0.5	0.0	0.5	-0.5	-0.5	-0.4	0.7
Latency to leave start box in cocaine runway	0.2	0.2	0.8	0.9	0.4	-0.4	-0.3	-0.4	-0.0
Latency to leave start box in cocaine runway, F	0.0	0.1	0.2	0.4	0.3	-0.3	-0.1	-0.1	-0.0
Latency to leave start box in cocaine runway, M	0.1	0.1	0.3	0.6	-0.0	0.0	-0.1	-0.3	-0.3
Std. dev. time between licks in bursts	0.3	0.6	1.3	-0.4	-0.7	0.7	0.6	1.1	-0.8
Total sessions with >9 infusions	0.1	0.2	0.7	0.8	0.2	-0.2	-0.2	-0.6	-0.1
Short access day 1 total inactive lever presses	1.4	2.8	3.9	2.0	1.8	-1.8	-1.8	-1.4	1.3
Short access day 10 total inactive lever presses	0.0	0.2	0.4	0.5	0.6	-0.6	-0.5	0.1	0.2
Short access day 1 total infusions	1.1	2.2	4.4	2.1	1.4	-1.4	-1.5	-1.5	0.9
Short access day 10 total infusions	1.0	1.6	4.1	2.0	1.0	-1.0	-1.0	-1.5	0.4
Short access total infusions	0.7	1.0	3.1	1.7	0.8	-0.8	-0.8	-1.1	0.2
Short access day 1 locomotion	1.3	2.2	3.3	1.8	1.5	-1.5	-1.5	-1.5	1.1
Short access day 10 total locomotion	0.6	2.5	3.5	1.8	1.5	-1.5	-1.5	-1.9	1.3
Short access total locomotion	1.9	2.9	3.9	2.0	1.6	-1.6	-1.6	-1.9	1.4
One hour access (0.3 mA shock)	8.0	9.5	10.0	3.0	3.2	-3.2	-3.2	-3.1	2.9
Compulsive drug intake	4.0	5.9	10.0	-2.4	-2.2	2.2	2.2	3.2	-2.3
One hour access (shock baseline)	5.7	14.8	18.8	3.6	3.8	-3.8	-3.8	-4.3	3.8
Social response proportion	0.2	0.3	0.5	-0.7	-0.6	0.6	0.6	0.2	-0.4
Social responses	0.2	0.3	0.6	-0.8	-0.5	0.5	0.6	0.5	-0.3
Social time	0.4	0.6	1.0	-1.0	-0.9	0.9	0.6	0.8	-0.5
Soleus weight	3.3	9.6	11.2	3.3	3.3	-3.3	-3.3	-2.5	2.7
Bone: stiffness	0.7	1.3	2.0	-1.0	-1.4	1.4	1.3	0.4	-1.2
Tibialis anterior weight	8.0	27.6	32.5	-5.7	-5.7	5.7	5.6	4.1	-4.5
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.2	0.0	-0.3	0.3	0.3	-0.1	-0.5
Time to tail flick, vehicle, after self-admin	0.6	1.3	3.4	-0.0	-1.0	1.0	1.1	1.0	-1.8
Time to tail flick, test, before self-admin	1.2	1.4	3.8	2.0	1.2	-1.2	-1.2	-0.7	0.3
Time to tail flick, test, after self-admin	0.1	0.1	0.2	-0.2	0.0	-0.0	-0.1	-0.5	0.3
Delta time to tail flick, vehicle, before/after SA	0.7	0.8	1.6	-0.3	-0.8	0.8	0.9	0.9	-1.3
Delta time to tail flick, test, before/after SA	1.0	1.3	4.8	-2.2	-1.0	1.0	0.9	0.3	0.2
Tibia length	0.2	0.5	1.5	-1.2	-0.6	0.6	0.7	-0.7	0.3
Ambulatory time before self-admin	0.0	0.1	0.5	-0.1	-0.0	0.0	0.1	-0.7	0.2
Ambulatory time after self-admin	0.3	0.6	0.7	0.6	0.8	-0.8	-0.7	-0.8	0.8
Bone: tissue strength	0.0	0.1	0.1	0.2	0.2	-0.2	-0.3	-0.3	0.2
Total heroin consumption	4.4	5.1	6.1	-2.5	-2.4	2.4	2.5	1.8	-1.9
Bone: trabecular number	0.1	0.3	0.5	-0.1	-0.6	0.6	0.7	-0.1	-0.7
Bone: trabecular spacing	0.0	0.1	0.2	0.2	0.2	-0.2	-0.3	0.5	0.0
Bone: trabecular thickness	0.5	0.6	1.2	1.1	0.8	-0.8	-0.9	-0.7	0.5
Bone: trabecular tissue density	3.3	5.9	6.9	2.1	2.6	-2.6	-2.5	-2.2	2.5
Water consumed over 24 hours	0.9	1.8	2.6	-1.6	-1.3	1.3	1.3	1.4	-0.9
Number of responses in last shaping day	0.1	0.1	0.2	-0.3	-0.2	0.2	0.1	0.5	-0.2