Hub : Genes

Gucy1b2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver intron excision ratio chr15_36640915_36643646 0.08 0.04 9.5e-11 0.1 0.09 0.09 0.1 6.3e-11 1.3e-10 2.1e-10 7.6e-11
2 Liver mRNA stability Gucy1b2 0.15 0.07 0.0e+00 0.19 0.2 0.16 0.18 1.1e-20 1.9e-21 1.4e-17 2.5e-19
3 Liver isoform ratio XM_008770741.3 0.24 0.11 0.0e+00 0.24 0.23 0.22 0.22 5.1e-26 3.8e-25 4.2e-24 1.8e-24
4 Liver alternative polyA NM_001270711.1 0.27 0.13 0.0e+00 0.15 0.16 0.14 0.16 1.8e-16 2.0e-17 4.1e-15 5.4e-17
5 LHb gene expression Gucy1b2 0.24 0.16 1.5e-03 0.09 0.1 0.09 0.1 4.3e-03 1.8e-03 4.7e-03 2.8e-03
6 Liver alternative polyA NM_001270711.1 0.27 0.13 5.6e-17 0.15 0.16 0.14 0.15 2.4e-16 2.5e-17 7.6e-15 8.9e-17
7 Liver alternative polyA XM_008770741.3 0.38 0.14 0.0e+00 0.22 0.22 0.2 0.22 7.7e-24 1.5e-24 6.3e-22 2.0e-23
8 Liver alternative polyA XM_008770741.3 0.37 0.14 0.0e+00 0.22 0.22 0.2 0.22 7.3e-24 1.4e-24 4.6e-22 2.0e-23
9 Liver isoform ratio NM_012770.2 0.36 0.15 2.5e-15 0.11 0.14 0.13 0.13 8.2e-12 6.5e-15 6.0e-14 1.8e-14
10 IL gene expression Gucy1b2 0.24 0.14 1.3e-03 0.09 0.03 0.06 0.05 4.3e-03 8.0e-02 2.0e-02 2.0e-02
11 PL gene expression Gucy1b2 0.42 0.11 0.0e+00 0.4 0.39 0.4 0.4 9.6e-47 4.9e-46 1.5e-46 2.1e-47
12 BLA gene expression Gucy1b2 0.31 0.13 0.0e+00 0.28 0.26 0.27 0.29 4.1e-15 3.7e-14 7.2e-15 1.2e-15
13 Brain mRNA stability Gucy1b2 0.05 0.03 1.3e-04 0.01 0.04 0.03 0.02 1.4e-02 1.8e-04 1.2e-03 2.6e-03
14 pVTA gene expression Gucy1b2 0.1 0.07 1.0e-03 0.06 0.04 0.03 0.04 9.7e-04 1.1e-02 2.1e-02 9.1e-03
15 NAcc gene expression Gucy1b2 0.23 0.08 0.0e+00 0.25 0.24 0.23 0.24 2.3e-28 2.0e-27 7.5e-27 1.5e-27
16 Brain gene expression Gucy1b2 0.23 0.11 0.0e+00 0.24 0.23 0.24 0.24 3.0e-22 2.7e-21 1.7e-22 1.6e-22
17 BLA mRNA stability Gucy1b2 0.18 0.1 6.0e-08 0.1 0.12 0.1 0.1 4.4e-06 7.7e-07 5.9e-06 3.1e-06
18 LHb alternative polyA XM_008770741.3 0.16 0.1 8.7e-03 0 0.03 0.02 0.01 2.5e-01 5.5e-02 1.2e-01 2.0e-01
19 LHb alternative polyA XM_008770741.3 0.16 0.1 8.2e-03 0.01 0.04 0.03 0.01 2.1e-01 3.5e-02 8.0e-02 1.6e-01
20 NAcc intron excision ratio chr15_36640915_36643646 0.1 0.06 1.2e-04 0.03 0.04 0.03 0.03 9.6e-05 4.9e-05 1.4e-04 1.3e-04
21 NAcc intron excision ratio chr15_36642868_36643646 0.09 0.06 2.2e-04 0.03 0.03 0.03 0.03 1.6e-04 7.8e-05 3.2e-04 2.0e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
Bone: apparent density0.30.51.7-1.20.6-0.8-1.10.5-1.11.21.2-1.3-0.10.10.30.5-0.8-0.10.10.50.20.2-0.20.3
Area under the delay curve3.13.34.81.6-2.21.61.9-1.71.9-1.8-1.81.61.7-1.8-1.8-2.21.81.8-1.8-2.2-1.1-1.1-2.22.1
BMI with tail0.41.21.91.0-0.91.21.3-1.21.3-1.4-1.41.41.0-0.9-0.9-0.41.11.0-0.8-0.5-1.3-1.3-0.90.9
BMI without tail0.00.10.30.00.4-0.1-0.10.1-0.10.10.1-0.0-0.10.20.20.6-0.1-0.20.30.3-0.1-0.10.4-0.4
Body weight0.72.94.61.6-1.91.91.5-1.81.5-1.4-1.41.21.9-1.9-1.7-1.71.42.0-1.7-1.7-1.6-1.6-2.22.1
Weight adjusted by age1.51.72.41.4-1.31.21.3-1.51.3-1.3-1.31.31.3-1.3-1.3-1.11.61.4-1.2-0.9-1.5-1.5-1.11.1
Bone surface0.30.51.4-0.80.5-0.7-1.00.6-1.01.11.1-1.2-0.30.30.50.4-0.9-0.20.30.60.40.4-0.00.0
Bone volume0.20.41.4-1.10.4-0.7-1.00.4-1.01.01.0-1.2-0.00.10.30.4-0.80.00.10.40.20.2-0.50.5
Breakpoint value in progressive ratio session0.00.00.2-0.1-0.1-0.1-0.10.0-0.10.20.2-0.20.3-0.2-0.1-0.1-0.40.2-0.1-0.2-0.0-0.0-0.30.3
Number of licking bursts0.20.30.40.2-0.30.40.6-0.60.6-0.6-0.60.70.5-0.6-0.6-0.10.40.3-0.6-0.2-0.6-0.6-0.30.3
Context. condit. distance diff. score0.30.30.8-0.80.5-0.6-0.60.8-0.60.60.6-0.7-0.50.50.50.3-0.7-0.40.50.10.90.90.1-0.1
Locomotion velocity, session 11.61.73.01.6-1.31.51.6-1.41.6-1.6-1.61.71.0-1.1-1.1-1.21.31.1-1.0-1.1-1.3-1.3-0.50.5
Locomotion distance, session 11.01.31.61.2-1.21.11.2-1.31.2-1.1-1.11.21.1-1.1-1.2-1.11.21.2-1.2-1.0-1.2-1.2-0.80.8
Locomotion velocity, session 20.50.62.70.1-0.70.10.0-0.50.00.10.1-0.30.8-0.8-0.7-0.60.41.2-0.8-0.7-0.6-0.6-1.61.7
Locomotion distance, session 20.20.31.0-0.2-0.1-0.2-0.4-0.2-0.50.50.5-0.70.6-0.4-0.4-0.10.00.8-0.5-0.1-0.6-0.6-0.91.0
Locomotion velocity, session 30.91.12.10.9-1.00.80.6-1.00.6-0.5-0.50.31.3-1.3-1.3-0.81.01.4-1.4-1.0-1.1-1.1-1.41.5
Locomotion distance, session 31.21.32.40.9-1.11.00.9-1.10.9-0.8-0.80.71.2-1.3-1.2-1.00.91.5-1.4-1.2-1.2-1.2-1.51.5
Stereotopy head waving bouts, day 31.01.22.1-1.11.2-1.2-1.41.2-1.41.41.4-1.4-0.90.90.90.9-0.8-1.00.90.81.11.10.8-0.8
Stereotopy head waving duration, day 30.10.10.30.4-0.30.30.2-0.30.2-0.2-0.20.20.3-0.4-0.5-0.40.50.3-0.4-0.4-0.2-0.2-0.10.1
Locomotion velocity, session 70.30.30.9-0.70.5-0.7-0.70.2-0.70.80.8-0.90.1-0.00.10.7-0.50.3-0.10.4-0.2-0.2-0.60.7
Locomotion distance, session 72.02.64.2-2.01.7-2.0-1.91.7-1.91.91.9-1.9-1.31.31.41.6-2.0-1.21.21.41.41.40.7-0.7
Stereotopy head waving bouts, day 73.13.55.01.9-1.91.81.7-2.01.7-1.7-1.71.51.9-2.1-2.1-1.62.22.0-1.9-1.7-2.0-2.0-1.81.8
Stereotopy head waving duration, day 74.45.37.12.4-2.42.32.2-2.42.2-2.2-2.22.02.4-2.5-2.5-2.12.72.5-2.4-2.2-2.3-2.3-2.22.2
Locomotion velocity, session 80.50.63.0-0.1-0.70.1-0.1-0.3-0.00.20.2-0.40.7-0.7-0.6-0.90.11.2-0.8-1.1-0.2-0.2-1.71.7
Locomotion distance, session 80.10.20.8-0.3-0.2-0.1-0.30.0-0.30.40.4-0.50.4-0.3-0.2-0.4-0.20.6-0.4-0.50.00.0-0.90.9
Degree of sensitization distance7.37.48.8-3.02.9-2.9-2.72.8-2.72.62.6-2.4-2.72.72.72.8-2.8-3.02.72.82.52.52.6-2.6
Degree of sensitization stereotypy3.84.25.32.2-2.22.22.1-2.12.1-2.1-2.12.01.9-2.0-2.0-2.12.32.1-1.9-2.1-1.8-1.8-1.81.7
Conditioned locomotion1.11.33.4-1.30.5-1.3-1.21.3-1.21.41.4-1.5-0.70.81.0-0.2-1.4-0.50.7-0.31.81.8-0.40.4
Cocaine response after cond. corrected0.20.30.8-0.50.4-0.5-0.20.6-0.10.10.1-0.1-0.90.70.70.5-0.5-0.40.70.20.70.70.3-0.3
Cocaine response after cond. not corrected0.20.20.7-0.40.4-0.5-0.10.6-0.10.10.1-0.1-0.80.70.70.4-0.6-0.40.70.10.70.70.3-0.3
Cocaine response before conditioning0.40.50.80.9-0.80.80.7-0.80.7-0.7-0.70.80.7-0.8-0.8-0.90.60.5-0.8-0.6-0.7-0.7-0.30.3
Saline control response0.20.30.9-0.00.2-0.2-0.20.5-0.20.20.2-0.2-0.40.40.3-0.40.0-0.70.4-0.11.01.00.8-0.9
Bone: connectivity density0.91.42.9-1.21.1-1.2-1.61.2-1.61.61.6-1.7-0.91.01.10.7-1.2-0.70.90.91.01.00.7-0.6
Bone: cortical apparent density1.01.33.11.1-0.81.31.5-1.11.5-1.6-1.61.81.0-1.0-1.2-0.51.40.6-0.9-0.8-1.0-1.00.1-0.0
Bone: cortical area0.00.00.2-0.1-0.10.00.2-0.20.2-0.2-0.20.20.2-0.1-0.10.20.10.1-0.20.1-0.2-0.2-0.40.4
Bone: cortical porosity1.41.54.21.0-1.50.80.6-0.80.6-0.5-0.50.21.3-1.3-1.2-2.01.11.4-1.3-1.9-0.3-0.3-1.91.9
Bone: cortical porosity1.31.44.11.0-1.50.80.7-0.80.7-0.6-0.60.41.3-1.3-1.2-2.01.11.4-1.3-1.9-0.3-0.3-1.71.7
Bone: cortical thickness0.30.50.90.6-0.70.60.9-0.70.9-0.9-0.90.90.6-0.6-0.7-0.40.90.6-0.6-0.5-0.6-0.6-0.60.6
Bone: cortical thickness1.11.31.71.0-1.11.01.3-1.11.3-1.3-1.31.21.0-1.0-1.0-0.81.11.3-1.0-1.1-1.1-1.1-1.31.3
Bone: cortical tissue density1.01.33.11.2-0.81.31.5-1.11.5-1.6-1.61.81.0-1.0-1.2-0.51.40.6-0.9-0.8-1.0-1.00.1-0.1
Condit. Reinf. active minus inactive responses1.92.13.21.8-1.41.81.6-1.71.6-1.7-1.71.81.5-1.3-1.4-1.21.51.2-1.2-0.9-1.8-1.8-0.40.4
Condit. Reinf. active-inactive response ratio0.20.20.40.50.00.40.4-0.40.4-0.5-0.50.60.2-0.1-0.20.20.5-0.1-0.00.3-0.6-0.60.6-0.6
Condit. Reinf. active responses3.13.86.02.3-2.12.42.3-2.22.3-2.3-2.32.41.9-1.7-1.8-2.01.81.6-1.6-1.6-2.0-2.0-0.70.7
Condit. Reinf. inactive responses1.61.94.01.4-1.71.71.6-1.41.6-1.5-1.51.61.2-1.3-1.2-2.00.91.2-1.3-1.7-0.9-0.9-0.80.8
Incentive salience index mean3.74.56.52.5-2.22.52.4-2.42.4-2.5-2.42.52.0-1.9-2.0-1.92.11.8-1.8-1.5-2.3-2.3-1.01.0
Condit. Reinf. lever presses4.35.89.12.9-2.62.82.9-2.72.9-2.9-2.93.02.1-2.0-2.1-2.32.31.9-1.9-1.8-2.4-2.4-1.21.1
Condit. Reinf. active minus inactive responses0.70.82.61.3-0.71.21.3-0.81.3-1.4-1.41.60.3-0.4-0.5-0.70.80.1-0.4-0.5-0.6-0.60.6-0.6
Condit. Reinf. active-inactive response ratio1.01.12.31.4-0.81.21.3-1.11.3-1.4-1.41.50.7-0.8-0.9-0.51.20.5-0.8-0.5-1.2-1.20.1-0.1
Condit. Reinf. active responses0.81.23.01.4-1.01.31.5-1.01.5-1.6-1.51.70.6-0.7-0.8-1.01.00.4-0.8-0.9-0.7-0.70.2-0.3
Condit. Reinf. inactive responses0.40.51.4-0.50.5-0.5-0.50.8-0.50.50.5-0.4-0.90.80.80.1-0.8-0.90.80.31.21.21.0-1.0
Condit. Reinf. lever presses3.54.87.92.8-2.22.52.4-2.42.4-2.4-2.42.42.1-2.1-2.2-2.12.31.9-2.1-1.8-2.3-2.3-1.01.0
Condit. Reinf. lever reinforcers received1.31.84.11.8-1.21.61.8-1.31.8-1.9-1.82.00.8-1.0-1.1-1.31.40.6-1.0-1.1-1.0-1.00.2-0.2
Conditioned reinforcement - actives8.98.915.5-2.72.9-2.6-2.23.0-2.22.02.1-1.6-3.73.73.42.4-2.8-3.63.42.83.23.23.9-3.9
Conditioned reinforcement - inactives3.94.45.6-2.22.3-2.3-2.42.1-2.42.32.3-2.3-1.91.91.92.1-2.2-2.01.92.21.71.71.8-1.8
Conditioned locomotion3.74.56.6-2.12.0-2.2-1.62.3-1.61.51.5-1.2-2.52.52.41.6-2.2-2.52.41.72.62.62.4-2.4
Patch foraging indifference point 0 sec0.20.21.1-0.40.3-0.4-0.80.4-0.80.90.8-1.0-0.00.10.20.2-0.4-0.20.10.30.30.3-0.40.4
Patch foraging indifference point AUC0.10.10.6-0.00.3-0.10.2-0.30.2-0.3-0.30.30.2-0.3-0.40.80.40.1-0.40.3-0.7-0.70.00.1
Delay disc. indifference point, 0s delay0.10.10.40.0-0.30.10.0-0.00.1-0.0-0.0-0.10.3-0.3-0.3-0.50.30.3-0.4-0.50.20.2-0.60.6
Delay disc. indifference point, 16s delay0.80.82.20.5-1.10.60.9-0.60.9-0.8-0.90.80.9-0.9-0.8-1.40.60.9-0.9-1.5-0.1-0.1-1.21.2
Delay disc. indifference point, 2s delay1.61.82.91.4-1.51.21.3-1.21.3-1.3-1.31.11.3-1.4-1.5-1.71.61.3-1.4-1.6-0.8-0.8-1.31.3
Delay disc. indifference point, 24s delay0.70.71.30.5-0.90.61.1-0.81.1-1.1-1.11.10.7-0.7-0.7-0.80.80.7-0.7-0.8-0.6-0.6-0.90.8
Delay disc. indifference point, 4s delay3.84.05.72.1-2.42.02.0-1.92.0-1.9-1.91.72.0-2.1-2.0-2.41.71.9-2.0-2.3-1.4-1.4-2.22.2
Delay disc. indifference point, 8s delay2.52.64.51.3-1.81.41.6-1.61.7-1.6-1.61.51.5-1.6-1.5-1.71.51.5-1.6-1.7-1.2-1.2-2.12.1
Indifference point function ln k0.30.51.50.6-1.00.70.6-0.60.6-0.5-0.50.40.6-0.6-0.5-1.20.40.7-0.6-0.9-0.2-0.2-0.90.8
Indifference point function log k0.30.51.50.6-1.00.70.6-0.60.6-0.5-0.50.40.6-0.6-0.5-1.20.40.7-0.6-0.9-0.2-0.2-0.90.8
Patch foraging total patch changes 0 sec0.10.20.7-0.0-0.2-0.0-0.4-0.0-0.40.50.4-0.70.4-0.4-0.2-0.30.00.3-0.3-0.20.00.0-0.90.9
Patch foraging total patch changes 12 sec0.30.41.00.4-0.30.50.4-0.70.4-0.4-0.40.40.7-0.8-0.7-0.00.60.6-0.7-0.2-1.0-1.0-0.60.7
Patch foraging total patch changes 18 sec0.10.10.20.1-0.20.10.1-0.20.2-0.1-0.10.10.3-0.5-0.5-0.10.40.4-0.4-0.5-0.2-0.2-0.40.5
Patch foraging total patch changes 24 sec0.40.51.30.4-0.60.30.3-0.60.3-0.1-0.20.00.9-1.1-0.8-0.70.30.8-1.0-0.9-0.6-0.6-1.11.2
Patch foraging total patch changes 6 sec0.00.00.30.10.3-0.0-0.1-0.1-0.10.10.1-0.10.2-0.2-0.10.60.2-0.2-0.10.4-0.3-0.30.00.0
Patch foraging time to switch 0 sec0.30.50.9-0.80.5-0.9-0.80.8-0.80.90.9-0.9-0.70.60.70.2-0.6-0.30.60.20.90.90.2-0.2
Patch foraging water rate 0 sec1.11.72.21.3-1.41.51.4-1.41.4-1.3-1.41.31.3-1.3-1.2-1.31.11.3-1.3-1.2-1.2-1.2-1.31.3
Patch foraging water rate 12 sec3.35.08.12.5-2.62.32.3-2.22.3-2.2-2.22.12.2-2.3-2.3-2.82.02.4-2.3-2.7-1.6-1.6-1.81.8
Patch foraging water rate 18 sec7.09.411.23.3-3.33.13.1-3.23.1-3.1-3.12.93.2-3.1-3.0-3.02.53.2-3.2-3.0-2.9-2.9-3.02.9
Patch foraging water rate 24 sec1.01.53.11.4-1.51.31.2-1.11.2-1.2-1.21.11.2-1.2-1.2-1.70.91.2-1.2-1.6-0.6-0.6-1.01.0
Patch foraging water rate 6 sec2.43.65.91.8-2.21.91.9-1.81.9-1.8-1.81.71.9-2.0-2.0-2.41.62.0-2.0-2.4-1.3-1.3-1.81.8
Seeking ratio, delayed vs. immediate footshock1.41.63.3-0.90.9-1.0-1.01.4-1.01.01.0-1.0-1.81.71.70.5-1.4-1.71.60.91.71.70.8-0.9
Distance traveled before self-admin0.00.00.30.0-0.2-0.1-0.00.1-0.00.10.1-0.1-0.00.1-0.1-0.50.2-0.10.0-0.40.40.50.2-0.2
Distance traveled after self-admin0.50.61.6-0.70.5-1.0-0.80.9-0.80.80.8-0.8-0.70.70.70.0-0.8-0.80.60.31.31.30.5-0.5
Extensor digitorum longus weight6.826.733.45.0-5.65.04.8-5.14.8-4.7-4.74.25.6-5.5-5.6-5.25.45.7-5.6-5.5-4.4-4.4-5.85.7
Bone: elastic displacement0.50.61.3-0.60.4-0.7-0.90.9-0.91.11.0-1.2-0.50.60.7-0.1-0.8-0.20.6-0.11.01.0-0.00.0
Bone: elastic work0.20.30.70.2-0.60.3-0.0-0.3-0.00.10.1-0.30.8-0.6-0.6-0.80.30.7-0.6-0.8-0.1-0.1-0.90.9
Bone: endosteal estimation0.51.02.0-1.20.9-1.1-1.30.9-1.31.31.3-1.4-0.70.70.80.8-1.2-0.90.60.90.80.80.2-0.2
Bone: endosteal perimeter1.02.03.3-1.51.3-1.6-1.71.5-1.71.71.7-1.8-1.21.31.41.0-1.6-1.21.21.21.41.40.6-0.6
Epididymis fat weight0.30.82.3-0.80.4-0.9-1.11.0-1.11.31.3-1.5-0.30.40.5-0.2-0.6-0.10.5-0.31.31.4-0.40.4
Delta time in closed arm before/after self-admin0.20.21.0-0.30.2-0.5-0.70.4-0.70.80.7-1.0-0.0-0.00.00.1-0.1-0.10.0-0.00.50.5-0.50.5
Delta time in open arm before/after self-admin3.43.36.9-1.52.1-1.4-1.31.5-1.31.21.2-0.9-2.12.22.22.6-2.0-2.12.12.60.90.92.1-2.1
Diff in mean of infusions in LGA sessions0.40.51.6-0.70.0-0.4-0.90.3-0.91.01.0-1.30.5-0.4-0.1-0.1-0.70.4-0.3-0.20.20.2-1.21.3
Delay discount exponential model param4.24.56.0-2.02.4-1.9-2.22.0-2.22.12.1-2.0-2.02.12.12.4-2.1-2.12.12.41.51.52.4-2.4
Extinction: sum of active levers before priming0.20.20.3-0.50.4-0.4-0.40.4-0.30.40.4-0.3-0.40.40.30.3-0.5-0.60.40.30.50.50.5-0.5
Active lever presses in extinction session 60.20.20.5-0.60.2-0.7-0.60.4-0.60.70.7-0.7-0.0-0.00.1-0.2-0.5-0.10.1-0.30.50.5-0.20.2
Bone: final force0.71.12.40.5-1.10.60.6-0.90.6-0.6-0.60.41.5-1.4-1.4-1.11.01.0-1.4-1.1-0.7-0.7-1.61.5
Bone: final moment0.91.42.80.7-1.30.90.8-1.10.8-0.7-0.70.51.7-1.6-1.5-1.41.21.2-1.6-1.4-0.8-0.8-1.61.6
Food consumed during 24 hour testing period0.20.30.80.4-0.40.60.6-0.60.6-0.6-0.60.70.5-0.5-0.6-0.40.90.4-0.4-0.2-0.7-0.7-0.00.0
Glucose0.40.61.70.5-0.50.70.7-1.00.7-0.7-0.70.70.9-1.0-0.90.00.70.9-0.8-0.3-1.3-1.3-0.70.7
Heart weight0.30.41.30.5-0.50.70.9-0.70.9-1.0-1.01.10.3-0.3-0.3-0.20.20.3-0.3-0.1-0.7-0.70.1-0.2
Delay discount hyperbolic model param4.44.66.3-2.12.5-2.0-2.22.1-2.22.22.2-2.0-2.12.22.12.5-2.1-2.12.12.51.51.52.4-2.3
Intermittent access intake day 1-15 change1.51.53.1-1.21.1-1.3-1.61.3-1.61.61.6-1.8-1.01.01.00.7-1.1-0.91.00.81.31.30.7-0.7
Intermittent access intake escalation1.91.83.5-1.31.3-1.4-1.71.5-1.71.71.7-1.9-1.11.11.10.9-1.2-1.21.20.91.51.50.9-0.9
Intermittent access intake escalation 20.60.61.0-0.70.9-0.7-1.00.8-1.01.01.0-1.0-0.60.60.60.7-0.8-0.70.60.70.80.70.8-0.8
Intermitt. access day 1 inactive lever presses5.35.79.5-2.72.8-2.8-2.72.2-2.72.62.6-2.5-2.22.22.23.1-2.4-2.22.12.91.51.51.7-1.7
Intermitt. access day 15 inactive lever presses1.61.72.9-1.41.4-1.6-1.61.3-1.61.61.6-1.7-1.21.11.21.2-1.4-1.21.01.41.01.00.7-0.7
Intermitt. access escalation Index0.30.20.80.3-0.10.20.4-0.50.4-0.4-0.40.40.6-0.6-0.50.30.40.5-0.5-0.0-0.9-0.9-0.30.3
Intermittent access day 1 total infusions0.50.61.1-1.10.7-1.0-0.80.9-0.70.80.8-0.7-0.80.80.70.6-0.7-0.70.60.51.01.00.5-0.5
Intermittent access day 15 total infusions3.43.85.3-2.22.0-2.3-2.22.1-2.22.22.2-2.2-1.81.81.71.7-1.9-1.81.61.62.02.01.4-1.4
Intermittent access terminal intake (last 3 days)2.93.25.2-2.21.9-2.3-2.22.0-2.22.22.2-2.3-1.41.41.41.7-1.9-1.51.21.41.71.71.0-0.9
Intermittent access total infusions3.84.26.0-2.32.1-2.5-2.22.3-2.22.22.1-2.1-2.12.01.91.9-2.1-2.11.81.82.22.21.5-1.5
Intermittent access day 1 locomotion0.20.20.6-0.80.4-0.7-0.30.4-0.30.30.3-0.2-0.50.40.50.4-0.5-0.40.40.30.50.50.1-0.1
Intermittent access day 15 total locomotion2.83.05.2-2.31.7-2.3-2.01.9-2.02.12.1-2.1-1.41.51.51.4-1.7-1.41.51.21.91.90.8-0.8
Intermittent access total locomotion1.71.93.1-1.81.3-1.7-1.41.5-1.41.41.4-1.4-1.41.31.31.2-1.6-1.31.21.21.51.50.8-0.8
Intermittent access standard deviation1.51.63.6-1.41.0-1.5-1.71.5-1.71.81.8-1.9-0.91.00.90.4-1.1-1.10.90.51.61.60.5-0.5
Left kidney weight2.57.19.52.5-2.93.12.6-3.02.6-2.6-2.62.52.7-2.6-2.6-2.52.22.9-2.6-2.3-3.0-3.0-2.52.5
Right kidney weight3.610.214.13.3-3.53.73.4-3.53.4-3.4-3.43.33.1-3.0-3.2-3.33.03.0-3.1-3.0-3.1-3.1-2.52.4
Cocaine induced anxiety0.30.41.20.7-0.80.60.6-0.50.6-0.6-0.60.60.4-0.5-0.7-1.10.70.4-0.8-0.8-0.1-0.1-0.50.4
Post-drug Anxiety0.00.00.20.2-0.20.1-0.2-0.1-0.20.20.2-0.30.1-0.1-0.3-0.40.3-0.1-0.4-0.0-0.0-0.0-0.30.3
Baseline Anxiety0.00.00.1-0.00.20.0-0.20.1-0.20.20.2-0.2-0.30.20.30.2-0.2-0.20.30.30.00.00.3-0.3
Tail length0.10.20.70.0-0.20.0-0.30.2-0.30.50.4-0.60.3-0.3-0.1-0.8-0.20.1-0.1-0.80.50.5-0.10.1
Length with tail0.20.62.10.1-0.80.4-0.3-0.2-0.30.40.4-0.70.9-0.9-0.6-1.3-0.20.9-0.8-1.20.10.1-1.41.4
Length without tail0.61.33.80.7-1.41.10.7-1.10.7-0.6-0.60.41.2-1.4-1.1-1.50.51.4-1.3-1.2-0.8-0.8-1.91.9
Times rat made contact with spout0.40.51.40.0-0.50.20.1-0.60.00.00.0-0.21.1-1.0-1.0-0.40.60.9-1.0-0.5-0.8-0.8-1.11.2
Lifetime Intake3.94.45.3-2.22.2-2.3-2.12.3-2.12.12.1-2.0-2.32.22.12.0-2.1-2.21.91.92.32.31.8-1.8
Liver weight, left4.36.88.72.5-2.72.72.7-2.82.7-2.7-2.72.62.9-2.9-2.9-2.42.72.4-2.8-2.5-2.5-2.5-2.12.1
Liver weight, right0.10.20.20.3-0.50.40.5-0.40.5-0.5-0.50.50.4-0.4-0.3-0.50.20.3-0.3-0.5-0.2-0.2-0.50.4
Locomotor activity3.25.17.82.2-2.62.21.8-2.21.8-1.6-1.71.32.5-2.4-2.4-2.72.22.8-2.4-2.5-1.9-1.9-2.82.7
Locomotor testing distance0.40.71.90.6-0.90.6-0.0-0.6-0.00.10.1-0.41.2-1.0-1.0-1.20.81.3-0.9-1.0-0.4-0.4-1.41.4
Locomotor testing rearing0.10.10.40.5-0.20.4-0.1-0.4-0.10.10.1-0.10.1-0.1-0.2-0.20.40.4-0.20.2-0.6-0.60.1-0.1
Locomotion in novel chamber1.21.51.91.4-1.41.31.1-1.21.1-1.0-1.00.91.4-1.4-1.2-1.41.31.3-1.2-1.4-1.1-1.1-1.41.4
Locomotion in novel chamber post-restriction0.30.41.8-0.6-0.1-0.6-0.70.3-0.70.80.8-1.00.2-0.00.1-0.4-0.30.5-0.2-0.40.40.4-1.41.3
Fecal boli incidents, locomotor time 13.03.24.52.1-1.61.81.9-2.02.0-2.0-2.02.01.8-1.8-1.9-1.02.01.7-1.9-1.3-2.1-2.1-1.31.3
Change in fecal boli incidents, locomotor task2.22.15.0-1.71.3-1.7-2.01.5-2.02.02.0-2.2-0.90.91.31.0-1.7-0.71.11.01.31.3-0.00.1
Time >=10cm from walls, locomotor time 10.10.10.40.5-0.30.2-0.2-0.1-0.20.20.2-0.40.3-0.3-0.4-0.70.20.2-0.3-0.40.10.1-0.20.2
Bouts of movement, locomotor time 10.70.71.80.6-0.70.70.6-0.90.6-0.5-0.50.40.9-1.0-0.9-0.30.91.0-0.9-0.5-1.1-1.1-1.31.3
Total resting periods, locomotor time 10.50.61.40.5-0.60.60.5-0.80.6-0.5-0.50.40.8-0.9-0.8-0.20.80.9-0.8-0.4-1.1-1.1-1.21.2
Rest time, locomotor task time 13.33.77.11.9-1.61.82.1-2.32.1-2.2-2.22.21.9-1.9-1.7-0.61.61.9-1.7-1.0-2.7-2.7-1.41.4
Distance moved, locomotor task time 11.92.14.5-1.51.2-1.2-1.51.7-1.51.61.6-1.6-1.41.41.30.4-1.3-1.41.30.62.12.11.3-1.3
Vertical activity count, locomotor time 11.92.05.4-1.50.8-1.3-1.71.8-1.61.81.8-1.9-1.11.11.2-0.2-1.4-0.91.1-0.12.32.30.5-0.5
Time >=10cm from walls, locomotor time 20.40.41.5-0.50.1-0.6-0.90.5-0.91.01.0-1.20.0-0.10.0-0.5-0.4-0.1-0.1-0.30.70.8-0.40.4
Bouts of movement, locomotor time 20.20.20.70.2-0.40.20.5-0.50.5-0.6-0.60.60.2-0.3-0.20.10.30.4-0.30.0-0.6-0.6-0.80.8
Total resting periods, locomotor time 20.60.61.30.5-0.60.50.9-0.90.9-0.9-0.90.90.6-0.6-0.50.00.60.7-0.6-0.1-1.1-1.1-1.01.0
Rest time, locomotor task time 22.93.46.71.6-1.51.82.0-2.22.0-2.1-2.12.11.9-1.8-1.6-0.61.31.9-1.7-0.9-2.6-2.6-1.51.5
Distance moved, locomotor task time 20.50.62.4-0.80.3-0.4-0.61.0-0.60.70.7-0.6-0.80.70.5-0.5-0.4-0.90.6-0.21.51.50.9-0.9
Vertical activity count, locomotor time 21.01.14.9-0.60.3-0.5-0.71.3-0.70.70.7-0.7-1.11.00.8-0.8-0.5-1.01.0-0.52.22.21.1-1.1
Light reinforcement 10.30.61.70.5-0.80.40.3-0.60.3-0.2-0.20.01.1-1.0-0.9-0.90.90.9-0.9-0.9-0.6-0.6-1.31.3
Light reinforcement 20.91.22.2-1.21.0-1.2-1.21.3-1.21.21.2-1.3-1.01.01.10.7-0.9-1.11.00.61.51.50.4-0.4
Bone: marrow area0.51.12.3-1.31.0-1.2-1.41.0-1.41.41.4-1.5-0.70.70.90.8-1.3-0.90.71.00.90.90.2-0.2
Bone: maximum diameter0.61.11.7-1.31.0-1.3-1.11.1-1.11.11.1-1.2-1.01.01.11.0-1.3-0.90.90.91.01.00.1-0.2
Bone: maximum force0.50.92.60.3-1.00.40.4-0.70.4-0.3-0.30.01.4-1.3-1.2-1.20.80.9-1.3-1.2-0.3-0.3-1.61.6
Bone: maximum moment0.71.22.60.6-1.20.70.6-0.90.6-0.5-0.50.31.6-1.5-1.5-1.51.01.2-1.5-1.4-0.5-0.5-1.61.6
Mean time between licks in bursts0.91.22.8-0.91.4-0.9-0.90.9-0.90.80.8-0.6-1.01.11.01.7-0.8-1.31.11.50.40.41.7-1.6
Mean num. licks in bursts0.00.00.20.1-0.20.1-0.2-0.1-0.20.20.2-0.30.3-0.1-0.1-0.30.10.4-0.1-0.2-0.1-0.1-0.30.3
Cd content in liver0.70.71.7-0.71.0-0.7-0.90.7-0.90.80.8-0.8-0.90.90.81.2-0.7-0.90.91.30.40.30.9-0.9
Co content in liver0.40.41.50.4-0.70.40.4-0.50.5-0.4-0.40.30.8-0.8-0.7-0.60.30.8-0.8-0.8-0.3-0.3-1.21.2
Cu content in liver1.21.42.80.9-1.01.00.9-1.40.9-0.9-0.90.81.4-1.3-1.3-0.61.21.4-1.4-0.7-1.7-1.7-1.41.4
Fe content in liver0.20.30.5-0.50.7-0.6-0.60.4-0.60.60.6-0.6-0.50.40.40.7-0.1-0.50.50.70.10.10.6-0.6
K content in liver0.40.41.5-0.80.4-0.8-0.90.8-0.91.01.0-1.20.1-0.00.10.1-0.5-0.20.0-0.20.90.9-0.40.4
Mg content in liver1.51.63.2-1.41.2-1.5-1.61.4-1.61.61.6-1.8-0.70.80.90.9-1.3-1.00.80.71.51.50.5-0.5
Mn content in liver1.01.12.1-1.41.0-1.1-1.11.3-1.11.21.1-1.2-0.80.80.80.6-1.0-1.20.90.61.51.50.8-0.8
Na content in liver2.72.84.51.4-1.91.61.3-1.71.3-1.2-1.21.02.1-2.1-2.0-2.01.61.7-2.1-1.8-1.4-1.3-1.91.9
Rb content in liver4.35.48.6-2.32.3-2.6-2.82.6-2.82.82.8-2.9-2.02.02.01.7-2.0-2.12.11.72.62.61.4-1.4
Se content in liver2.73.34.1-2.01.7-2.0-2.01.9-2.02.02.0-2.0-1.91.91.91.4-1.9-1.71.91.71.91.91.1-1.1
Sr content in liver0.60.51.5-0.70.9-0.2-0.30.2-0.30.20.20.0-0.70.70.71.2-0.8-0.60.71.2-0.3-0.41.2-1.2
Zn content in liver0.91.02.40.6-1.20.80.6-0.90.5-0.4-0.50.31.4-1.3-1.1-1.40.61.2-1.3-1.2-0.7-0.7-1.61.5
Bone: minimum diameter0.10.30.6-0.60.4-0.7-0.70.4-0.70.70.7-0.8-0.20.30.40.5-0.5-0.40.30.50.40.4-0.20.2
Time in familiar zone, hab. session 10.40.40.80.8-0.50.70.8-0.50.8-0.8-0.80.90.5-0.3-0.6-0.50.90.3-0.3-0.6-0.3-0.30.1-0.1
Time in novel zone, hab. session 10.60.61.6-1.10.7-1.0-1.10.7-1.11.11.1-1.3-0.40.30.60.7-1.1-0.30.20.60.40.4-0.40.4
Total zone transitions, hab. session 10.60.91.40.7-0.90.80.9-1.00.9-0.8-0.90.81.1-1.1-1.1-0.71.01.0-1.2-0.8-0.9-0.9-1.21.1
Total locomotion distance, hab. session 10.10.10.4-0.1-0.2-0.1-0.1-0.1-0.10.20.1-0.30.6-0.6-0.6-0.20.30.3-0.6-0.4-0.1-0.0-0.60.6
Locomotion velocity, hab. session 10.20.30.70.3-0.50.30.2-0.30.2-0.1-0.10.00.8-0.8-0.8-0.80.70.4-0.8-0.7-0.1-0.1-0.70.7
Time in familiar zone, hab. session 20.40.41.6-0.50.3-0.5-0.50.8-0.40.50.5-0.4-0.60.60.6-0.2-0.3-0.70.8-0.11.31.30.6-0.7
Time in novel zone, hab. session 20.20.20.90.3-0.10.20.1-0.50.1-0.1-0.10.10.4-0.4-0.40.20.10.6-0.50.1-0.9-0.9-0.60.6
Total zone transitions, hab. session 22.02.64.31.4-1.81.31.3-1.51.3-1.2-1.21.01.9-1.9-1.8-1.91.41.9-2.0-1.9-1.3-1.3-2.12.1
Total locomotion distance, hab. session 21.21.65.00.6-1.30.50.5-0.90.5-0.3-0.40.11.6-1.6-1.4-1.40.91.7-1.6-1.6-0.8-0.7-2.22.2
Locomotion velocity, hab. session 21.41.95.20.7-1.40.70.7-1.10.7-0.6-0.60.31.7-1.7-1.6-1.51.01.8-1.8-1.7-1.0-0.9-2.32.3
Novel to familiar place preference ratio1.91.92.9-1.51.4-1.5-1.71.3-1.71.71.7-1.7-1.41.41.41.4-1.6-1.01.31.51.01.00.7-0.6
Novelty place preference1.81.83.2-1.51.3-1.5-1.71.3-1.71.71.7-1.8-1.41.31.41.3-1.5-0.81.21.40.90.90.5-0.5
Time in novel zone, NPP test1.71.73.0-1.41.3-1.4-1.61.2-1.61.71.7-1.7-1.31.31.31.2-1.5-0.81.21.40.90.90.5-0.5
Total zone transitions, NPP test1.11.62.01.1-1.31.21.2-1.31.2-1.2-1.21.21.3-1.3-1.3-1.21.11.3-1.4-1.2-1.3-1.3-1.21.2
Total locomotion distance, NPP test0.10.10.2-0.50.3-0.4-0.50.0-0.50.50.5-0.50.1-0.1-0.00.5-0.40.1-0.10.5-0.3-0.3-0.10.1
Locomotion velocity, NPP test0.10.10.2-0.40.2-0.3-0.4-0.1-0.40.40.4-0.40.2-0.3-0.20.4-0.20.2-0.30.3-0.4-0.4-0.30.3
Intraocular pressure1.92.66.5-1.11.5-1.0-1.21.6-1.21.11.2-0.9-1.92.01.81.0-1.4-2.01.91.41.61.62.5-2.5
Delta distance traveled before/after self-admin0.90.91.8-0.91.1-0.9-0.80.9-0.90.80.8-0.7-1.01.01.21.2-1.2-1.11.01.30.70.70.8-0.9
Delta ambulatory time before/after self-admin0.60.71.1-0.90.9-0.9-0.80.8-0.80.70.7-0.7-0.80.80.90.9-1.1-0.90.80.90.70.70.7-0.7
Parametrial fat weight3.46.69.8-2.82.5-2.9-3.03.0-2.93.03.0-3.1-2.42.32.41.9-2.9-2.32.21.63.03.01.5-1.4
Pavlov. Cond. lever latency1.62.04.9-1.71.3-1.7-1.91.6-1.92.02.0-2.2-0.90.90.90.9-1.2-0.80.90.61.61.60.4-0.3
Pavlov. Cond. magazine entry latency0.20.31.10.7-0.40.70.8-0.50.8-0.9-0.91.10.00.0-0.0-0.30.2-0.40.10.2-0.3-0.30.6-0.6
Pavlov. Cond. change in total contacts1.01.12.91.4-1.11.31.5-1.21.4-1.6-1.61.70.4-0.4-0.5-0.71.00.5-0.4-0.3-1.1-1.1-0.20.2
Pavlov. Cond. index score2.53.16.62.1-1.82.12.3-2.12.3-2.4-2.42.61.2-1.3-1.3-1.31.51.2-1.2-0.9-1.9-2.0-0.80.7
Pavlov. Cond. latency score2.22.86.72.0-1.62.02.3-2.02.2-2.4-2.42.61.1-1.1-1.1-1.11.41.0-1.0-0.7-1.9-1.9-0.50.4
Pavlov. Cond. lever contacts2.12.55.91.9-1.61.92.1-1.82.1-2.2-2.22.41.0-1.0-1.0-1.11.31.0-1.0-0.7-1.7-1.7-0.50.4
Pavlov. Cond. magazine entry number1.01.32.8-1.51.1-1.4-1.51.3-1.51.61.5-1.7-0.80.80.80.8-0.9-0.50.70.41.21.20.2-0.2
Pavlov. Cond. intertrial magazine entries1.51.82.51.5-1.51.51.4-1.41.4-1.4-1.41.31.4-1.3-1.5-1.61.51.2-1.4-1.5-1.1-1.1-0.80.8
Pavlov. Cond. lever-magazine prob. diff.2.83.46.72.2-1.92.22.4-2.22.3-2.5-2.42.61.4-1.4-1.4-1.31.61.3-1.4-1.0-2.1-2.1-1.00.9
Pavlov. Cond. response bias2.63.26.32.2-1.92.22.3-2.02.3-2.4-2.42.51.4-1.4-1.4-1.61.51.2-1.3-1.2-1.8-1.8-0.80.7
Pavlov. Cond. lever latency3.85.17.6-2.82.3-2.5-2.32.5-2.32.32.3-2.3-2.22.22.32.1-2.5-2.12.31.92.42.41.6-1.5
Pavlov. Cond. magazine entry latency1.92.23.91.9-1.81.81.7-1.41.7-1.7-1.71.71.1-1.2-1.3-2.01.61.2-1.2-1.7-0.9-0.9-0.90.9
Pavlov. Cond. change in total contacts4.46.08.72.9-2.62.62.5-2.52.5-2.4-2.42.42.5-2.6-2.6-2.62.52.3-2.6-2.4-2.2-2.2-1.91.9
Pavlov. Cond. index score4.05.28.32.9-2.52.62.5-2.42.5-2.5-2.52.52.1-2.1-2.2-2.52.41.9-2.1-2.2-2.0-1.9-1.41.4
Pavlov. Cond. latency score3.94.98.02.8-2.42.62.5-2.32.4-2.4-2.42.42.0-2.0-2.1-2.52.31.9-2.0-2.1-1.9-1.9-1.31.3
Pavlov. Cond. lever contacts3.24.47.12.7-2.22.32.1-2.32.1-2.1-2.02.02.1-2.1-2.2-2.22.32.1-2.1-1.9-2.1-2.1-1.51.5
Pavlov. Cond. magazine entry number1.92.43.6-1.91.7-1.7-1.71.5-1.71.71.7-1.7-1.31.41.51.8-1.8-1.31.41.61.11.11.0-1.0
Pavlov. Cond. intertrial magazine entries2.63.55.8-1.92.2-1.8-1.91.6-1.91.81.8-1.6-1.81.81.92.4-1.9-1.81.82.40.90.82.0-2.0
Pavlov. Cond. lever-magazine prob. diff.3.74.87.62.8-2.42.52.5-2.32.5-2.5-2.52.52.0-2.0-2.1-2.42.31.8-2.0-2.1-1.8-1.8-1.31.2
Pavlov. Cond. response bias3.95.38.32.9-2.52.62.4-2.42.4-2.4-2.42.42.1-2.2-2.3-2.52.52.1-2.2-2.2-2.1-2.1-1.61.5
Time in closed arm before self-admin1.92.23.91.3-1.61.21.2-1.41.2-1.1-1.10.91.5-1.5-1.7-1.51.81.7-1.6-1.5-1.3-1.3-2.02.0
Time in closed arm after self-admin3.13.25.41.7-2.01.61.5-1.71.5-1.4-1.41.11.9-2.0-2.0-2.02.22.0-1.9-1.9-1.4-1.4-2.32.3
Time in open arm before self-admin0.40.42.00.4-0.80.40.2-0.20.2-0.1-0.1-0.00.7-0.7-0.7-1.40.60.6-0.7-1.30.20.2-0.50.5
Time in open arm after self-admin2.12.34.3-1.61.9-1.4-1.51.3-1.51.51.5-1.3-1.41.41.52.1-1.7-1.51.42.00.80.81.7-1.6
Bone: periosteal estimation0.40.81.3-1.20.9-1.1-1.10.9-1.11.11.1-1.1-0.80.80.91.0-1.1-0.90.71.10.70.70.2-0.3
Bone: periosteal perimeter0.30.50.8-0.70.7-0.9-0.80.7-0.80.80.8-0.8-0.60.70.70.8-0.7-0.70.60.90.50.50.2-0.2
Bone: post-yield work0.10.10.6-0.4-0.2-0.3-0.10.1-0.00.10.1-0.20.4-0.4-0.4-0.30.10.3-0.4-0.60.30.4-0.80.8
Progressive ratio test 1 active lever presses0.60.61.5-1.20.9-1.2-0.90.8-0.80.80.8-0.8-0.70.60.61.1-0.8-0.60.40.80.60.60.3-0.3
Progressive ratio test 1 breakpoint0.70.71.8-1.31.0-1.3-1.00.8-1.01.01.0-1.0-0.70.60.51.2-0.8-0.50.30.80.60.60.1-0.1
Progressive ratio test 1 inactive lever presses1.21.32.5-1.61.4-1.5-1.31.2-1.31.31.3-1.2-1.11.00.91.4-1.2-1.00.71.20.80.80.8-0.8
Progressive ratio test 2 active lever presses3.94.27.3-2.02.4-2.1-2.01.9-2.01.91.9-1.7-2.32.21.92.7-1.7-2.21.92.51.31.32.2-2.1
Progressive ratio test 2 breakpoint2.73.05.9-1.82.1-1.8-1.71.6-1.71.71.7-1.5-1.91.81.62.4-1.5-1.81.52.30.90.91.8-1.7
Progressive ratio test 2 inactive lever presses1.61.83.9-1.21.7-1.1-1.11.1-1.11.01.0-0.8-1.61.51.22.0-1.0-1.61.21.90.50.51.8-1.8
Incentive Sensitization - Responses2.62.65.1-1.12.0-1.3-1.41.3-1.41.21.3-1.1-1.91.91.72.2-1.3-1.71.82.20.60.62.3-2.2
Incentive Sensitization - Breakpoint2.42.44.6-1.11.9-1.3-1.41.2-1.41.31.3-1.1-1.81.81.62.1-1.3-1.61.72.20.60.52.1-2.0
Sum of active levers in priming session hrs 5-60.00.00.1-0.00.1-0.00.1-0.00.1-0.1-0.10.20.10.00.10.2-0.3-0.10.10.1-0.2-0.20.3-0.3
Progressive ratio0.10.10.40.1-0.40.20.2-0.20.2-0.1-0.10.00.3-0.3-0.2-0.50.00.6-0.4-0.6-0.1-0.1-0.50.5
Food seeking constrained by brief footshock0.20.30.8-0.40.7-0.4-0.20.5-0.10.10.10.0-0.70.60.50.8-0.6-0.70.60.60.40.40.9-0.9
Seeking ratio, punishment vs. effort0.00.00.20.00.10.00.2-0.00.2-0.3-0.30.3-0.10.1-0.10.20.1-0.40.10.20.00.00.3-0.3
Retroperitoneal fat weight0.41.22.9-0.90.9-0.8-1.11.4-1.11.21.2-1.3-0.91.11.00.4-0.9-1.11.20.41.71.70.7-0.7
Reaction time number correct0.10.10.3-0.20.4-0.3-0.20.1-0.20.20.2-0.1-0.20.10.20.5-0.1-0.30.20.5-0.1-0.10.5-0.5
Reaction time mean minus median0.10.20.60.6-0.50.60.5-0.20.5-0.5-0.50.5-0.20.1-0.1-0.80.7-0.30.0-0.40.10.10.3-0.3
Reaction time mean minus median AUC0.20.30.60.7-0.10.60.6-0.20.5-0.6-0.60.7-0.50.40.1-0.10.7-0.50.30.2-0.2-0.20.7-0.8
Reaction time num false alarms0.30.41.2-0.0-0.50.2-0.1-0.5-0.10.20.2-0.41.0-0.9-0.9-0.50.60.8-0.9-0.4-0.5-0.6-1.11.1
Reaction time num false alarms AUC0.50.71.90.3-0.70.40.2-0.80.2-0.1-0.1-0.21.3-1.2-1.2-0.71.01.2-1.1-0.7-0.9-0.9-1.31.4
Reaction time trials correct on left0.10.10.3-0.20.4-0.3-0.20.1-0.20.20.2-0.1-0.20.10.20.5-0.1-0.30.20.5-0.1-0.10.5-0.5
Reaction time trials on left0.10.10.4-0.20.5-0.3-0.30.2-0.30.20.2-0.1-0.30.20.20.6-0.2-0.40.30.7-0.1-0.10.6-0.6
Reaction time mean0.40.61.0-0.60.5-0.5-0.60.8-0.60.60.6-0.5-1.00.90.90.1-0.6-1.00.90.31.01.00.9-0.9
Reaction time mean AUC0.50.71.3-0.60.6-0.6-0.60.9-0.60.60.6-0.5-1.11.11.00.2-0.7-1.11.10.51.11.11.0-1.0
Median of all reaction times0.60.91.5-0.90.7-0.8-0.81.0-0.80.80.8-0.7-1.01.11.10.2-1.0-1.01.10.41.21.21.0-1.0
Reaction time omissions1.62.14.5-0.91.7-1.0-1.11.2-1.11.01.0-0.8-1.81.91.61.8-1.0-1.61.81.90.70.72.1-2.1
Reaction time false alarm rate0.60.82.40.3-0.80.50.3-0.80.3-0.2-0.2-0.01.3-1.2-1.1-0.70.91.2-1.1-0.8-0.9-0.9-1.51.6
Reaction time premature initiation rate0.30.31.20.6-0.70.40.3-0.30.3-0.2-0.20.10.7-0.7-0.8-1.10.70.5-0.7-1.00.00.0-0.60.6
Reaction time premature initiations0.10.10.40.3-0.30.10.0-0.10.00.00.0-0.10.4-0.5-0.5-0.60.40.2-0.4-0.60.10.1-0.20.2
Std. dev. reaction times0.30.41.0-0.20.4-0.2-0.30.6-0.30.20.3-0.2-1.00.90.80.2-0.3-1.00.90.50.70.71.0-1.0
Reaction time trials completed0.10.10.4-0.20.5-0.3-0.30.2-0.30.20.2-0.1-0.30.20.20.6-0.2-0.40.30.7-0.1-0.10.6-0.6
Reaction time trials AUC0.10.10.4-0.30.5-0.4-0.40.2-0.40.30.3-0.3-0.30.20.20.6-0.2-0.30.20.60.00.00.6-0.5
Run reversals in cocaine runway, females0.90.91.6-0.50.9-0.6-0.91.1-0.90.90.9-0.9-1.01.00.90.4-0.7-1.20.90.71.31.31.2-1.2
Run reversals in cocaine runway, males1.11.12.01.4-1.11.41.3-1.01.3-1.4-1.31.30.6-0.8-1.1-1.11.20.6-0.9-0.9-0.6-0.6-0.40.3
Latency to leave start box in cocaine runway0.70.71.2-0.71.0-0.7-0.80.8-0.80.80.8-0.7-0.81.01.11.1-0.9-0.71.01.10.50.50.8-0.8
Latency to leave start box in cocaine runway, F1.31.42.8-0.91.3-1.1-1.01.0-1.00.90.9-0.8-1.41.51.41.5-1.3-1.31.41.70.70.71.3-1.3
Latency to leave start box in cocaine runway, M0.20.20.50.6-0.10.70.3-0.40.3-0.3-0.30.30.5-0.3-0.20.10.50.3-0.1-0.0-0.7-0.70.1-0.1
Std. dev. time between licks in bursts2.12.54.0-1.31.6-1.4-1.51.7-1.61.51.5-1.4-1.51.61.61.1-1.5-2.01.61.41.81.81.9-1.9
Total sessions with >9 infusions5.56.17.9-2.52.6-2.4-2.32.4-2.32.22.2-2.0-2.82.72.62.7-2.6-2.72.52.82.22.22.4-2.4
Short access day 1 total inactive lever presses0.20.20.5-0.70.6-0.6-0.60.5-0.60.60.6-0.5-0.30.30.40.6-0.6-0.50.30.50.40.40.3-0.3
Short access day 10 total inactive lever presses0.10.10.5-0.10.3-0.20.0-0.20.0-0.0-0.00.1-0.00.0-0.10.70.20.0-0.10.5-0.7-0.70.1-0.1
Short access day 1 total infusions5.55.87.3-2.72.5-2.7-2.52.6-2.42.42.4-2.3-2.42.52.42.3-2.5-2.52.22.32.52.52.0-2.0
Short access day 10 total infusions0.50.51.3-0.90.5-0.8-0.70.9-0.70.70.7-0.7-0.70.70.70.3-0.9-0.70.60.31.11.20.3-0.3
Short access total infusions2.42.73.8-1.81.6-1.8-1.71.8-1.71.61.6-1.6-1.71.71.61.4-1.7-1.81.51.41.91.91.2-1.3
Short access day 1 locomotion1.92.13.0-1.61.5-1.6-1.41.5-1.41.31.3-1.2-1.51.51.61.5-1.7-1.51.31.61.41.41.1-1.1
Short access day 10 total locomotion0.10.10.50.4-0.30.30.5-0.30.5-0.6-0.60.7-0.20.10.0-0.20.4-0.10.10.0-0.2-0.20.2-0.3
Short access total locomotion0.30.30.6-0.60.4-0.5-0.20.4-0.20.10.10.1-0.70.60.70.5-0.8-0.60.60.70.40.40.7-0.7
One hour access (0.3 mA shock)2.02.46.0-1.01.6-1.0-0.81.4-0.80.60.6-0.3-2.12.01.71.7-1.0-2.01.81.81.31.32.4-2.5
Compulsive drug intake1.41.43.31.6-1.01.61.6-1.21.6-1.7-1.71.80.7-0.7-0.7-0.81.20.8-0.6-0.7-1.2-1.2-0.10.1
One hour access (shock baseline)4.85.56.7-2.52.4-2.6-2.42.5-2.42.42.4-2.3-2.42.42.32.2-2.3-2.42.22.22.42.42.0-2.0
Social response proportion3.03.34.3-1.81.9-1.7-1.81.9-1.81.81.8-1.7-2.12.02.01.7-2.1-1.51.91.81.61.61.7-1.7
Social responses1.31.73.4-0.91.4-1.0-1.11.2-1.11.01.0-0.8-1.41.51.41.2-1.2-1.31.51.51.11.11.8-1.8
Social time0.60.82.61.1-0.60.60.5-1.00.4-0.4-0.40.30.7-0.8-0.9-0.21.31.2-0.9-0.2-1.6-1.6-1.01.0
Soleus weight0.61.83.91.3-1.21.51.8-1.41.8-1.9-1.92.01.3-1.3-1.4-0.91.30.8-1.2-1.1-1.1-1.1-0.50.5
Bone: stiffness0.20.31.6-0.1-0.30.00.0-0.40.00.0-0.0-0.20.7-0.8-0.7-0.10.30.5-0.9-0.2-0.5-0.5-1.31.2
Tibialis anterior weight7.525.631.94.9-5.34.94.8-5.24.8-4.6-4.74.25.4-5.4-5.4-4.65.15.6-5.4-5.0-4.8-4.8-5.65.6
Time to tail flick, vehicle, before self-admin0.10.10.60.3-0.40.10.00.00.00.00.0-0.1-0.0-0.0-0.3-0.80.70.1-0.2-0.50.40.4-0.10.0
Time to tail flick, vehicle, after self-admin0.30.31.40.1-0.40.1-0.3-0.1-0.30.40.4-0.70.7-0.7-0.5-0.50.30.8-0.4-0.7-0.1-0.1-1.21.2
Time to tail flick, test, before self-admin0.90.91.71.1-1.01.10.8-0.90.8-0.8-0.70.61.1-1.1-1.3-1.11.10.9-1.3-1.1-0.8-0.8-0.60.6
Time to tail flick, test, after self-admin1.71.73.3-0.71.3-1.1-1.11.4-1.11.01.0-0.9-1.61.51.40.9-0.8-1.51.71.11.31.31.8-1.8
Delta time to tail flick, vehicle, before/after SA0.30.30.8-0.50.4-0.4-0.70.2-0.60.70.7-0.90.2-0.20.10.7-0.50.40.10.3-0.3-0.3-0.60.7
Delta time to tail flick, test, before/after SA2.22.03.6-0.91.4-1.2-1.01.4-1.00.90.9-0.7-1.91.81.81.1-1.2-1.61.91.31.41.41.8-1.9
Tibia length0.71.94.71.5-1.21.51.0-1.70.9-1.0-1.00.81.6-1.6-1.5-0.71.31.5-1.5-0.4-2.2-2.2-1.31.3
Ambulatory time before self-admin0.50.61.50.7-1.00.70.8-0.60.8-0.8-0.80.70.6-0.6-0.8-1.20.90.6-0.8-1.1-0.2-0.2-0.50.4
Ambulatory time after self-admin0.20.21.0-0.0-0.6-0.10.10.00.1-0.0-0.0-0.00.4-0.3-0.3-1.00.00.3-0.4-0.90.50.5-0.70.6
Bone: tissue strength0.30.30.7-0.50.6-0.5-0.70.6-0.70.70.7-0.7-0.20.30.20.4-0.4-0.70.40.40.60.50.8-0.8
Total heroin consumption0.60.72.41.1-0.61.01.2-0.81.2-1.3-1.31.50.2-0.2-0.4-0.30.70.2-0.2-0.3-0.8-0.80.4-0.5
Bone: trabecular number0.61.02.0-1.30.8-1.0-1.31.0-1.31.41.4-1.4-0.70.81.00.6-1.3-0.50.80.70.80.80.3-0.3
Bone: trabecular spacing0.20.30.60.4-0.60.50.8-0.40.8-0.8-0.80.80.3-0.4-0.5-0.60.50.3-0.4-0.8-0.1-0.0-0.40.4
Bone: trabecular thickness0.81.02.30.6-0.90.70.6-1.10.6-0.6-0.60.41.3-1.3-1.2-0.70.81.2-1.3-0.8-1.2-1.2-1.51.5
Bone: trabecular tissue density0.81.11.61.1-0.90.91.2-1.11.2-1.3-1.31.31.1-1.1-1.1-0.51.10.9-1.0-0.8-1.1-1.1-0.90.9
Water consumed over 24 hours0.40.51.00.3-0.80.70.7-0.80.7-0.6-0.60.61.0-1.0-0.8-0.90.40.6-0.9-0.7-0.6-0.6-0.70.7
Number of responses in last shaping day1.61.73.9-1.80.9-1.7-1.71.4-1.71.81.8-2.0-0.50.60.80.5-1.5-0.70.50.31.61.6-0.20.2