Hub : Genes

Slc22a6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	OFC	alternative TSS	NM_017224.2	0.13	0.08	6.3e-03	0.09	0.08	0.05	0.07	4.5e-03	6.2e-03	2.7e-02	9.3e-03
2	OFC	alternative TSS	XM_006230978.3	0.15	0.09	2.7e-03	0.1	0.1	0.07	0.09	2.2e-03	2.8e-03	7.7e-03	3.6e-03
3	Brain	mRNA stability	Slc22a6	0.11	0.06	2.9e-10	0.09	0.1	0.09	0.1	1.6e-08	9.0e-10	4.7e-09	1.4e-09
4	OFC	isoform ratio	XM_006230978.3	0.15	0.09	5.2e-03	0.07	0.04	-0.01	0.06	1.1e-02	3.4e-02	5.8e-01	1.9e-02
5	OFC	isoform ratio	NM_017224.2	0.14	0.09	8.2e-03	0.06	0.05	-0	0.05	1.4e-02	3.1e-02	3.9e-01	2.2e-02
6	PL	mRNA stability	Slc22a6	0.03	0.02	2.6e-04	0.04	0.03	0.04	0.04	4.4e-05	2.9e-04	6.8e-05	4.6e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	0.1	0.2	0.4	-0.6	0.6	0.3	0.3	-0.3	-0.5
Area under the delay curve	0.0	0.0	0.1	-0.0	0.0	0.2	0.3	-0.3	-0.3
BMI with tail	2.0	6.6	7.2	-2.7	2.7	2.2	2.7	-2.7	-2.4
BMI without tail	1.1	2.3	2.9	-1.4	1.4	1.5	1.7	-1.7	-1.4
Body weight	3.9	16.5	17.8	-4.1	4.1	3.8	4.2	-4.2	-3.9
Weight adjusted by age	1.4	1.5	2.1	-1.4	1.4	1.0	1.3	-1.3	-0.9
Bone surface	1.1	1.9	3.2	-1.8	1.8	0.9	1.0	-1.0	-1.4
Bone volume	0.3	0.5	1.2	-1.1	1.1	0.3	0.3	-0.3	-0.7
Breakpoint value in progressive ratio session	1.6	1.7	2.4	-1.5	1.5	1.2	1.2	-1.2	-1.2
Number of licking bursts	0.0	0.0	0.0	-0.0	0.0	-0.1	0.0	-0.0	-0.1
Context. condit. distance diff. score	0.4	0.5	0.8	0.9	-0.9	-0.4	-0.7	0.7	0.1
Locomotion velocity, session 1	0.1	0.1	0.2	-0.0	0.0	0.4	0.2	-0.2	-0.5
Locomotion distance, session 1	0.6	0.8	1.8	-0.7	0.7	0.9	0.8	-0.8	-1.3
Locomotion velocity, session 2	2.9	3.3	3.8	-1.8	1.8	1.6	1.9	-1.9	-2.0
Locomotion distance, session 2	0.4	0.5	0.9	-0.4	0.4	0.8	0.8	-0.8	-1.0
Locomotion velocity, session 3	0.4	0.5	0.8	-0.6	0.6	0.5	0.7	-0.7	-0.9
Locomotion distance, session 3	0.2	0.2	0.3	-0.4	0.4	0.5	0.6	-0.6	-0.4
Stereotopy head waving bouts, day 3	0.2	0.2	0.3	0.5	-0.5	-0.5	-0.3	0.3	-0.4
Stereotopy head waving duration, day 3	0.3	0.3	0.4	0.6	-0.6	-0.5	-0.6	0.6	-0.4
Locomotion velocity, session 7	0.1	0.1	0.1	0.3	-0.3	-0.3	-0.1	0.1	-0.1
Locomotion distance, session 7	0.1	0.1	0.2	0.5	-0.5	0.0	0.1	-0.1	-0.1
Stereotopy head waving bouts, day 7	0.2	0.2	0.3	-0.3	0.3	-0.3	-0.6	0.6	-0.5
Stereotopy head waving duration, day 7	1.3	1.5	2.4	-1.6	1.6	1.0	0.8	-0.8	-1.5
Locomotion velocity, session 8	0.1	0.1	0.3	0.4	-0.4	0.3	0.0	-0.0	-0.5
Locomotion distance, session 8	0.2	0.4	0.6	0.8	-0.8	-0.5	-0.6	0.6	-0.1
Degree of sensitization distance	0.1	0.1	0.3	0.5	-0.5	-0.3	-0.2	0.2	0.0
Degree of sensitization stereotypy	0.5	0.5	1.1	-1.1	1.1	0.4	0.1	-0.1	-0.8
Conditioned locomotion	0.6	0.7	0.8	-0.8	0.8	0.9	0.8	-0.8	-0.9
Cocaine response after cond. corrected	0.5	0.6	1.5	1.2	-1.2	-0.3	-0.5	0.5	0.2
Cocaine response after cond. not corrected	0.4	0.5	1.1	1.0	-1.0	-0.3	-0.4	0.4	0.5
Cocaine response before conditioning	0.3	0.3	0.7	-0.8	0.8	0.2	0.3	-0.3	0.5
Saline control response	3.0	3.9	4.1	-1.9	1.9	2.0	2.0	-2.0	-1.9
Bone: connectivity density	1.2	1.9	2.5	-1.6	1.6	1.2	1.2	-1.2	-1.4
Bone: cortical apparent density	0.4	0.6	1.0	-0.7	0.7	0.9	0.6	-0.6	-1.0
Bone: cortical area	0.7	1.0	1.6	-1.2	1.2	0.6	0.9	-0.9	-0.9
Bone: cortical porosity	0.0	0.1	0.1	0.3	-0.3	-0.2	-0.2	0.2	-0.1
Bone: cortical porosity	0.0	0.0	0.2	-0.1	0.1	0.2	0.1	-0.1	-0.4
Bone: cortical thickness	3.6	5.9	6.3	-2.3	2.3	2.5	2.5	-2.5	-2.4
Bone: cortical thickness	0.9	1.0	1.6	-0.7	0.7	1.3	1.2	-1.2	-0.9
Bone: cortical tissue density	0.6	0.7	1.3	-0.8	0.8	1.0	0.7	-0.7	-1.1
Condit. Reinf. active minus inactive responses	1.0	1.1	1.5	-1.2	1.2	1.0	0.9	-0.9	-1.1
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.6	-0.7	0.7	0.7	0.4	-0.4	-0.8
Condit. Reinf. active responses	0.7	0.8	1.5	-1.2	1.2	0.6	0.7	-0.7	-0.9
Condit. Reinf. inactive responses	0.1	0.1	0.3	-0.2	0.2	-0.5	-0.2	0.2	0.5
Incentive salience index mean	1.3	1.5	2.0	-1.4	1.4	1.1	1.1	-1.1	-1.1
Condit. Reinf. lever presses	0.7	0.9	1.3	-1.2	1.2	0.8	0.9	-0.9	-0.8
Condit. Reinf. active minus inactive responses	0.6	0.8	1.2	0.5	-0.5	-1.1	-1.1	1.1	0.8
Condit. Reinf. active-inactive response ratio	1.8	1.9	3.1	0.8	-0.8	-1.8	-1.7	1.7	1.1
Condit. Reinf. active responses	0.0	0.0	0.0	-0.2	0.2	-0.1	-0.1	0.1	0.0
Condit. Reinf. inactive responses	0.6	0.7	1.3	-0.5	0.5	1.1	1.1	-1.1	-0.5
Condit. Reinf. lever presses	0.6	0.8	1.6	-1.3	1.3	0.7	0.7	-0.7	-0.5
Condit. Reinf. lever reinforcers received	0.1	0.1	0.2	-0.5	0.5	0.1	0.1	-0.1	-0.1
Conditioned reinforcement - actives	3.1	3.1	4.0	1.5	-1.5	-2.0	-1.9	1.9	1.8
Conditioned reinforcement - inactives	1.3	1.5	2.5	0.9	-0.9	-1.6	-1.3	1.3	1.3
Conditioned locomotion	2.5	3.0	3.6	1.6	-1.6	-1.9	-1.9	1.9	1.6
Patch foraging indifference point 0 sec	0.5	0.8	1.3	-1.0	1.0	0.8	0.7	-0.7	-1.1
Patch foraging indifference point AUC	1.6	1.8	3.1	-1.8	1.8	1.0	1.1	-1.1	-1.2
Delay disc. indifference point, 0s delay	0.1	0.1	0.4	0.6	-0.6	-0.1	0.0	-0.0	0.1
Delay disc. indifference point, 16s delay	0.0	0.0	0.1	-0.3	0.3	0.0	0.2	-0.2	-0.2
Delay disc. indifference point, 2s delay	0.2	0.2	0.3	0.5	-0.5	-0.6	-0.4	0.4	0.5
Delay disc. indifference point, 24s delay	0.3	0.3	0.4	-0.3	0.3	0.7	0.6	-0.6	-0.5
Delay disc. indifference point, 4s delay	0.6	0.7	1.1	-0.4	0.4	0.9	0.9	-0.9	-1.1
Delay disc. indifference point, 8s delay	0.1	0.1	0.4	0.6	-0.6	-0.1	-0.2	0.2	0.0
Indifference point function ln k	2.4	3.4	6.2	2.5	-2.5	-1.1	-1.5	1.5	1.5
Indifference point function log k	2.4	3.4	6.2	2.5	-2.5	-1.1	-1.5	1.5	1.5
Patch foraging total patch changes 0 sec	0.6	1.0	1.5	-0.9	0.9	1.1	0.9	-0.9	-1.2
Patch foraging total patch changes 12 sec	5.9	7.6	8.8	-3.0	3.0	2.5	2.5	-2.5	-3.0
Patch foraging total patch changes 18 sec	0.3	0.4	0.7	-0.8	0.8	0.5	0.5	-0.5	-0.8
Patch foraging total patch changes 24 sec	7.3	9.0	11.0	-3.1	3.1	2.8	2.8	-2.8	-3.3
Patch foraging total patch changes 6 sec	1.2	1.8	2.3	-1.3	1.3	1.3	1.3	-1.3	-1.5
Patch foraging time to switch 0 sec	0.1	0.2	0.4	-0.7	0.7	0.1	0.3	-0.3	-0.4
Patch foraging water rate 0 sec	0.2	0.4	0.6	0.8	-0.8	-0.4	-0.6	0.6	0.6
Patch foraging water rate 12 sec	0.8	1.2	2.4	1.6	-1.6	-0.6	-0.7	0.7	1.0
Patch foraging water rate 18 sec	0.3	0.4	1.0	1.0	-1.0	0.0	-0.1	0.1	0.2
Patch foraging water rate 24 sec	0.9	1.3	2.2	1.5	-1.5	-0.7	-0.9	0.9	1.0
Patch foraging water rate 6 sec	0.5	0.7	1.7	1.3	-1.3	-0.4	-0.4	0.4	0.7
Seeking ratio, delayed vs. immediate footshock	0.0	0.1	0.1	-0.1	0.1	0.2	0.3	-0.3	-0.2
Distance traveled before self-admin	1.9	2.0	3.1	-1.7	1.7	1.1	1.2	-1.2	-1.3
Distance traveled after self-admin	0.2	0.3	0.5	-0.7	0.7	0.4	0.4	-0.4	-0.3
Extensor digitorum longus weight	6.9	27.2	29.6	-5.4	5.4	4.9	5.1	-5.1	-5.3
Bone: elastic displacement	0.3	0.3	0.7	0.8	-0.8	-0.1	-0.2	0.2	0.4
Bone: elastic work	1.3	1.6	2.2	-0.9	0.9	1.5	1.5	-1.5	-1.3
Bone: endosteal estimation	1.4	3.1	4.3	1.5	-1.5	-2.1	-1.7	1.7	1.8
Bone: endosteal perimeter	2.4	4.9	7.7	1.8	-1.8	-2.8	-2.3	2.3	2.3
Epididymis fat weight	0.3	0.6	1.3	0.7	-0.7	-1.0	-0.4	0.4	1.2
Delta time in closed arm before/after self-admin	2.5	2.4	3.6	-1.0	1.0	1.9	1.7	-1.7	-1.8
Delta time in open arm before/after self-admin	0.9	0.9	1.6	-1.3	1.3	0.6	0.7	-0.7	-0.9
Diff in mean of infusions in LGA sessions	1.7	1.9	2.1	-1.4	1.4	1.4	1.3	-1.3	-1.5
Delay discount exponential model param	0.0	0.0	0.1	0.0	-0.0	-0.2	-0.2	0.2	0.3
Extinction: sum of active levers before priming	3.8	3.8	4.5	-2.1	2.1	1.8	1.8	-1.8	-2.0
Active lever presses in extinction session 6	2.1	2.0	3.1	-1.8	1.8	1.2	1.2	-1.2	-1.3
Bone: final force	1.7	2.7	3.6	-1.9	1.9	1.4	1.5	-1.5	-1.7
Bone: final moment	1.7	2.7	3.6	-1.9	1.9	1.4	1.5	-1.5	-1.6
Food consumed during 24 hour testing period	0.1	0.1	0.3	0.1	-0.1	-0.4	-0.4	0.4	0.5
Glucose	2.8	4.3	4.9	2.0	-2.0	-2.2	-1.9	1.9	2.2
Heart weight	0.7	0.9	1.7	1.3	-1.3	-0.7	-0.7	0.7	0.9
Delay discount hyperbolic model param	0.1	0.1	0.1	0.0	-0.0	-0.2	-0.3	0.3	0.4
Intermittent access intake day 1-15 change	1.9	1.9	2.4	1.2	-1.2	-1.6	-1.4	1.4	1.5
Intermittent access intake escalation	1.2	1.2	1.5	0.9	-0.9	-1.2	-1.1	1.1	1.2
Intermittent access intake escalation 2	0.1	0.1	0.3	0.1	-0.1	-0.5	-0.4	0.4	0.4
Intermitt. access day 1 inactive lever presses	2.2	2.3	2.9	1.5	-1.5	-1.7	-1.6	1.6	1.4
Intermitt. access day 15 inactive lever presses	0.1	0.1	0.2	-0.3	0.3	-0.4	0.1	-0.1	0.1
Intermitt. access escalation Index	0.1	0.1	0.2	0.5	-0.5	0.1	-0.0	0.0	0.1
Intermittent access day 1 total infusions	1.0	1.1	1.8	0.9	-0.9	-1.3	-1.0	1.0	1.0
Intermittent access day 15 total infusions	4.4	4.9	6.6	2.0	-2.0	-2.6	-2.2	2.2	2.3
Intermittent access terminal intake (last 3 days)	1.2	1.4	2.7	0.8	-0.8	-1.6	-1.2	1.2	1.2
Intermittent access total infusions	1.4	1.6	2.7	1.0	-1.0	-1.6	-1.2	1.2	1.3
Intermittent access day 1 locomotion	0.1	0.1	0.2	0.4	-0.4	-0.5	-0.3	0.3	0.2
Intermittent access day 15 total locomotion	0.4	0.4	0.9	0.3	-0.3	-0.9	-0.7	0.7	0.6
Intermittent access total locomotion	0.4	0.4	1.3	0.2	-0.2	-1.1	-0.7	0.7	0.5
Intermittent access standard deviation	2.0	2.1	2.5	1.2	-1.2	-1.5	-1.6	1.6	1.5
Left kidney weight	0.0	0.0	0.0	-0.1	0.1	-0.2	0.0	-0.0	0.0
Right kidney weight	0.0	0.1	0.1	-0.4	0.4	-0.1	0.2	-0.2	-0.3
Cocaine induced anxiety	0.1	0.2	0.3	-0.5	0.5	0.1	0.3	-0.3	-0.3
Post-drug Anxiety	0.4	0.4	0.8	-0.9	0.9	0.3	0.6	-0.6	-0.6
Baseline Anxiety	1.3	1.4	1.7	-1.1	1.1	1.3	1.2	-1.2	-1.2
Tail length	1.2	3.5	4.3	-1.7	1.7	2.1	2.0	-2.0	-1.8
Length with tail	2.7	9.9	10.2	-3.2	3.2	3.1	3.2	-3.2	-3.1
Length without tail	2.3	5.0	5.3	-2.3	2.3	2.0	2.3	-2.3	-2.2
Times rat made contact with spout	0.3	0.3	0.5	-0.3	0.3	0.7	0.6	-0.6	-0.7
Lifetime Intake	1.1	1.3	1.8	1.0	-1.0	-1.3	-1.1	1.1	1.2
Liver weight, left	0.2	0.3	0.5	0.7	-0.7	-0.4	-0.4	0.4	0.7
Liver weight, right	0.1	0.2	0.6	-0.0	0.0	0.4	0.8	-0.8	-0.1
Locomotor activity	0.3	0.5	1.2	1.1	-1.1	-0.2	-0.5	0.5	0.6
Locomotor testing distance	0.4	0.6	1.6	1.3	-1.3	-0.1	-0.3	0.3	0.6
Locomotor testing rearing	0.5	0.8	1.7	1.3	-1.3	-0.5	-0.5	0.5	1.0
Locomotion in novel chamber	2.9	3.5	5.0	1.5	-1.5	-2.2	-1.9	1.9	2.1
Locomotion in novel chamber post-restriction	2.9	3.5	3.8	2.0	-2.0	-2.0	-1.9	1.9	1.4
Fecal boli incidents, locomotor time 1	0.7	0.8	1.3	0.3	-0.3	-1.1	-1.1	1.1	0.9
Change in fecal boli incidents, locomotor task	0.3	0.3	0.9	0.9	-0.9	-0.1	-0.0	0.0	0.1
Time >=10cm from walls, locomotor time 1	3.2	3.2	4.9	1.3	-1.3	-2.2	-2.0	2.0	1.7
Bouts of movement, locomotor time 1	0.1	0.1	0.3	-0.5	0.5	0.3	0.1	-0.1	-0.2
Total resting periods, locomotor time 1	0.1	0.1	0.3	-0.5	0.5	0.2	0.1	-0.1	-0.1
Rest time, locomotor task time 1	1.4	1.5	1.7	1.3	-1.3	-1.1	-1.2	1.2	1.1
Distance moved, locomotor task time 1	0.2	0.2	0.3	-0.6	0.6	0.5	0.4	-0.4	-0.4
Vertical activity count, locomotor time 1	0.6	0.6	0.6	0.8	-0.8	-0.7	-0.7	0.7	0.8
Time >=10cm from walls, locomotor time 2	0.4	0.4	0.7	0.1	-0.1	-0.8	-0.8	0.8	0.6
Bouts of movement, locomotor time 2	1.4	1.5	1.6	-1.3	1.3	1.3	1.3	-1.3	-1.1
Total resting periods, locomotor time 2	0.7	0.7	0.8	-0.9	0.9	0.8	0.9	-0.9	-0.7
Rest time, locomotor task time 2	3.3	3.7	4.5	2.1	-2.1	-1.9	-1.9	1.9	1.7
Distance moved, locomotor task time 2	0.4	0.5	0.7	-0.9	0.9	0.8	0.5	-0.5	-0.4
Vertical activity count, locomotor time 2	0.1	0.1	0.2	0.1	-0.1	0.5	0.2	-0.2	-0.0
Light reinforcement 1	0.0	0.1	0.1	0.3	-0.3	-0.3	-0.2	0.2	0.4
Light reinforcement 2	0.6	0.8	2.0	0.3	-0.3	-1.4	-1.0	1.0	1.0
Bone: marrow area	1.6	3.4	4.7	1.7	-1.7	-2.2	-1.8	1.8	1.9
Bone: maximum diameter	0.1	0.1	0.2	-0.5	0.5	-0.4	-0.1	0.1	-0.1
Bone: maximum force	1.9	3.3	4.9	-2.2	2.2	1.3	1.6	-1.6	-1.7
Bone: maximum moment	1.9	3.2	4.8	-2.2	2.2	1.3	1.7	-1.7	-1.6
Mean time between licks in bursts	1.5	2.1	3.3	-0.9	0.9	1.8	1.8	-1.8	-1.0
Mean num. licks in bursts	0.0	0.0	0.0	0.2	-0.2	0.2	0.0	-0.0	-0.0
Cd content in liver	1.9	2.1	3.1	1.2	-1.2	-1.5	-1.8	1.8	1.2
Co content in liver	1.2	1.3	2.6	1.6	-1.6	-0.5	-0.8	0.8	1.1
Cu content in liver	0.3	0.3	0.6	-0.5	0.5	0.7	0.4	-0.4	-0.8
Fe content in liver	0.1	0.1	0.3	0.1	-0.1	-0.4	-0.5	0.5	0.1
K content in liver	1.0	0.9	1.2	-1.1	1.1	0.7	1.0	-1.0	-0.9
Mg content in liver	0.3	0.3	0.5	-0.6	0.6	0.3	0.4	-0.4	-0.7
Mn content in liver	1.7	1.9	3.1	-1.8	1.8	1.1	1.0	-1.0	-1.3
Na content in liver	0.4	0.4	0.8	-0.9	0.9	0.4	0.5	-0.5	-0.6
Rb content in liver	1.2	1.5	2.3	1.5	-1.5	-1.1	-1.1	1.1	1.1
Se content in liver	0.2	0.2	0.4	-0.6	0.6	-0.4	-0.4	0.4	-0.0
Sr content in liver	5.6	5.1	5.9	-2.4	2.4	2.0	2.2	-2.2	-2.3
Zn content in liver	3.7	4.1	4.8	-2.2	2.2	1.8	1.9	-1.9	-2.2
Bone: minimum diameter	0.7	1.3	2.3	0.9	-0.9	-1.5	-1.1	1.1	1.3
Time in familiar zone, hab. session 1	0.2	0.2	0.2	-0.4	0.4	0.4	0.5	-0.5	0.2
Time in novel zone, hab. session 1	1.1	1.1	1.7	1.3	-1.3	-0.8	-0.9	0.9	0.9
Total zone transitions, hab. session 1	0.3	0.4	1.3	-0.5	0.5	0.6	0.5	-0.5	-1.1
Total locomotion distance, hab. session 1	0.1	0.1	0.2	0.3	-0.3	-0.5	-0.4	0.4	-0.2
Locomotion velocity, hab. session 1	0.1	0.1	0.6	-0.3	0.3	0.1	0.2	-0.2	-0.8
Time in familiar zone, hab. session 2	0.2	0.2	0.7	0.5	-0.5	0.2	0.3	-0.3	0.8
Time in novel zone, hab. session 2	0.3	0.3	0.7	-0.7	0.7	0.3	0.2	-0.2	-0.8
Total zone transitions, hab. session 2	1.8	2.3	2.7	-1.4	1.4	1.5	1.6	-1.6	-1.6
Total locomotion distance, hab. session 2	0.2	0.3	0.5	-0.3	0.3	0.5	0.7	-0.7	-0.7
Locomotion velocity, hab. session 2	0.1	0.1	0.3	-0.1	0.1	0.1	0.4	-0.4	-0.6
Novel to familiar place preference ratio	1.6	1.7	3.0	-1.7	1.7	0.9	1.0	-1.0	-1.2
Novelty place preference	0.9	0.9	1.9	-1.4	1.4	0.6	0.7	-0.7	-0.8
Time in novel zone, NPP test	1.0	1.1	2.0	-1.4	1.4	0.7	0.8	-0.8	-0.9
Total zone transitions, NPP test	1.2	1.8	3.0	-1.2	1.2	1.3	1.2	-1.2	-1.7
Total locomotion distance, NPP test	0.1	0.2	0.5	-0.1	0.1	0.4	0.4	-0.4	-0.7
Locomotion velocity, NPP test	0.1	0.1	0.5	-0.0	0.0	0.2	0.2	-0.2	-0.7
Intraocular pressure	0.2	0.3	0.5	0.2	-0.2	-0.6	-0.7	0.7	0.5
Delta distance traveled before/after self-admin	0.3	0.4	0.7	0.8	-0.8	-0.3	-0.4	0.4	0.6
Delta ambulatory time before/after self-admin	0.6	0.7	1.2	1.1	-1.1	-0.5	-0.6	0.6	0.8
Parametrial fat weight	1.5	2.8	3.7	1.6	-1.6	-1.9	-1.7	1.7	1.7
Pavlov. Cond. lever latency	1.0	1.2	1.8	1.3	-1.3	-0.9	-1.0	1.0	1.0
Pavlov. Cond. magazine entry latency	0.7	0.9	1.8	-1.3	1.3	0.7	0.8	-0.8	-0.5
Pavlov. Cond. change in total contacts	0.2	0.2	0.5	-0.7	0.7	-0.2	-0.2	0.2	0.0
Pavlov. Cond. index score	0.4	0.5	1.1	-1.0	1.0	0.5	0.5	-0.5	-0.4
Pavlov. Cond. latency score	0.4	0.5	0.9	-0.9	0.9	0.5	0.5	-0.5	-0.4
Pavlov. Cond. lever contacts	0.2	0.3	0.4	-0.6	0.6	0.4	0.6	-0.6	-0.3
Pavlov. Cond. magazine entry number	0.4	0.4	1.1	1.1	-1.1	-0.4	-0.3	0.3	0.3
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.1	-0.2	0.2	-0.3	-0.3	0.3	0.0
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	1.3	-1.1	1.1	0.5	0.6	-0.6	-0.5
Pavlov. Cond. response bias	0.5	0.6	1.2	-1.1	1.1	0.5	0.6	-0.6	-0.3
Pavlov. Cond. lever latency	0.3	0.4	0.7	0.8	-0.8	-0.5	-0.5	0.5	0.2
Pavlov. Cond. magazine entry latency	3.8	4.4	5.6	-2.4	2.4	2.1	2.1	-2.1	-1.5
Pavlov. Cond. change in total contacts	0.9	1.2	2.6	-1.6	1.6	0.7	0.8	-0.8	-0.5
Pavlov. Cond. index score	1.8	2.4	4.0	-2.0	2.0	1.3	1.4	-1.4	-0.9
Pavlov. Cond. latency score	1.6	2.0	3.4	-1.9	1.9	1.2	1.3	-1.3	-0.8
Pavlov. Cond. lever contacts	0.2	0.3	0.6	-0.8	0.8	0.4	0.4	-0.4	0.0
Pavlov. Cond. magazine entry number	6.0	7.3	10.1	3.2	-3.2	-2.5	-2.6	2.6	2.1
Pavlov. Cond. intertrial magazine entries	1.7	2.2	2.5	1.5	-1.5	-1.6	-1.6	1.6	1.1
Pavlov. Cond. lever-magazine prob. diff.	2.2	2.8	4.5	-2.1	2.1	1.5	1.5	-1.5	-1.0
Pavlov. Cond. response bias	1.2	1.7	2.7	-1.6	1.6	1.2	1.2	-1.2	-0.7
Time in closed arm before self-admin	0.1	0.2	0.4	0.1	-0.1	-0.6	-0.4	0.4	0.5
Time in closed arm after self-admin	0.4	0.4	0.7	0.8	-0.8	-0.4	-0.4	0.4	0.6
Time in open arm before self-admin	0.4	0.4	1.1	1.0	-1.0	0.1	-0.2	0.2	0.2
Time in open arm after self-admin	0.1	0.1	0.2	-0.1	0.1	0.4	0.3	-0.3	-0.4
Bone: periosteal estimation	0.1	0.3	0.8	0.1	-0.1	-0.9	-0.5	0.5	0.5
Bone: periosteal perimeter	0.1	0.1	0.5	-0.1	0.1	-0.7	-0.3	0.3	0.4
Bone: post-yield work	0.8	1.1	2.1	0.5	-0.5	-1.4	-1.1	1.1	1.1
Progressive ratio test 1 active lever presses	2.6	2.7	3.1	1.5	-1.5	-1.7	-1.8	1.8	1.6
Progressive ratio test 1 breakpoint	2.9	3.1	3.5	1.6	-1.6	-1.8	-1.9	1.9	1.7
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.1	-0.1	0.1	0.3	0.3	-0.3	-0.3
Progressive ratio test 2 active lever presses	2.4	2.6	3.7	1.4	-1.4	-1.9	-1.7	1.7	1.6
Progressive ratio test 2 breakpoint	3.6	4.1	5.2	1.8	-1.8	-2.3	-2.1	2.1	2.0
Progressive ratio test 2 inactive lever presses	1.1	1.2	2.2	0.8	-0.8	-1.5	-1.1	1.1	1.1
Incentive Sensitization - Responses	0.0	0.0	0.1	-0.3	0.3	-0.3	0.0	-0.0	0.0
Incentive Sensitization - Breakpoint	0.0	0.0	0.2	-0.2	0.2	-0.4	-0.1	0.1	0.2
Sum of active levers in priming session hrs 5-6	0.5	0.5	1.2	-1.1	1.1	0.2	0.3	-0.3	-0.5
Progressive ratio	0.0	0.1	0.1	-0.3	0.3	-0.2	0.1	-0.1	0.2
Food seeking constrained by brief footshock	0.0	0.1	0.1	0.3	-0.3	0.1	0.2	-0.2	-0.0
Seeking ratio, punishment vs. effort	0.1	0.1	0.3	0.5	-0.5	0.4	0.1	-0.1	-0.3
Retroperitoneal fat weight	2.3	7.5	8.6	2.9	-2.9	-2.8	-2.5	2.5	2.8
Reaction time number correct	0.9	1.4	1.8	-1.1	1.1	1.2	1.3	-1.3	-0.9
Reaction time mean minus median	0.1	0.2	0.4	-0.7	0.7	-0.2	-0.1	0.1	0.0
Reaction time mean minus median AUC	0.0	0.0	0.1	-0.4	0.4	-0.0	-0.1	0.1	0.1
Reaction time num false alarms	0.1	0.2	0.5	0.7	-0.7	0.4	0.1	-0.1	0.1
Reaction time num false alarms AUC	0.3	0.3	0.9	0.2	-0.2	1.0	0.6	-0.6	-0.6
Reaction time trials correct on left	0.9	1.4	1.8	-1.1	1.1	1.2	1.3	-1.3	-0.9
Reaction time trials on left	1.0	1.4	1.8	-1.1	1.1	1.3	1.3	-1.3	-0.9
Reaction time mean	0.3	0.4	0.6	0.3	-0.3	-0.6	-0.8	0.8	0.7
Reaction time mean AUC	0.4	0.5	0.8	0.3	-0.3	-0.8	-0.9	0.9	0.9
Median of all reaction times	0.1	0.1	0.2	0.1	-0.1	-0.3	-0.5	0.5	0.4
Reaction time omissions	0.0	0.0	0.1	-0.0	0.0	0.3	-0.0	0.0	-0.2
Reaction time false alarm rate	0.2	0.2	0.6	0.8	-0.8	0.1	-0.2	0.2	0.1
Reaction time premature initiation rate	5.6	7.5	9.2	-2.4	2.4	2.9	3.0	-3.0	-2.5
Reaction time premature initiations	7.4	10.5	12.8	-2.9	2.9	3.4	3.6	-3.6	-2.9
Std. dev. reaction times	0.3	0.5	0.8	0.3	-0.3	-0.7	-0.9	0.9	0.7
Reaction time trials completed	1.0	1.4	1.8	-1.1	1.1	1.3	1.3	-1.3	-0.9
Reaction time trials AUC	0.8	1.2	1.6	-1.0	1.0	1.2	1.3	-1.3	-0.8
Run reversals in cocaine runway, females	1.5	1.5	1.9	-0.8	0.8	1.4	1.4	-1.4	-1.4
Run reversals in cocaine runway, males	0.4	0.4	0.7	0.8	-0.8	-0.6	-0.6	0.6	0.4
Latency to leave start box in cocaine runway	0.4	0.4	0.6	0.5	-0.5	-0.8	-0.7	0.7	0.6
Latency to leave start box in cocaine runway, F	0.0	0.0	0.0	-0.1	0.1	-0.1	-0.1	0.1	-0.0
Latency to leave start box in cocaine runway, M	3.4	3.2	3.5	1.9	-1.9	-1.8	-1.7	1.7	1.8
Std. dev. time between licks in bursts	0.1	0.2	0.2	0.4	-0.4	0.5	0.5	-0.5	0.3
Total sessions with >9 infusions	1.6	1.8	2.1	1.5	-1.5	-1.3	-1.2	1.2	1.4
Short access day 1 total inactive lever presses	0.8	0.9	0.9	1.0	-1.0	-0.9	-0.9	0.9	0.9
Short access day 10 total inactive lever presses	1.9	2.1	2.8	1.7	-1.7	-1.2	-1.4	1.4	1.3
Short access day 1 total infusions	0.8	0.9	1.2	1.1	-1.1	-0.9	-0.7	0.7	1.0
Short access day 10 total infusions	0.2	0.3	0.5	0.5	-0.5	-0.7	-0.5	0.5	0.5
Short access total infusions	0.4	0.4	0.5	0.7	-0.7	-0.6	-0.5	0.5	0.6
Short access day 1 locomotion	0.0	0.0	0.1	-0.1	0.1	0.1	0.2	-0.2	-0.2
Short access day 10 total locomotion	0.0	0.0	0.0	-0.0	0.0	-0.1	0.1	-0.1	-0.2
Short access total locomotion	0.1	0.1	0.2	-0.3	0.3	0.2	0.4	-0.4	-0.5
One hour access (0.3 mA shock)	4.6	5.4	6.8	2.2	-2.2	-2.6	-2.3	2.3	2.3
Compulsive drug intake	2.4	2.4	4.2	-1.1	1.1	2.0	1.7	-1.7	-1.4
One hour access (shock baseline)	7.2	8.4	11.6	2.5	-2.5	-3.4	-3.0	3.0	2.8
Social response proportion	0.2	0.2	0.4	-0.5	0.5	0.5	0.6	-0.6	-0.1
Social responses	0.2	0.2	0.4	-0.3	0.3	0.6	0.6	-0.6	-0.3
Social time	0.1	0.1	0.2	0.1	-0.1	0.3	0.4	-0.4	-0.3
Soleus weight	2.5	7.2	8.5	2.9	-2.9	-2.6	-2.5	2.5	2.6
Bone: stiffness	0.5	0.8	1.6	-1.3	1.3	0.4	0.6	-0.6	-0.6
Tibialis anterior weight	9.9	33.7	37.8	-6.1	6.1	5.4	5.5	-5.5	-6.1
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.4	-0.6	0.6	0.2	0.5	-0.5	-0.5
Time to tail flick, vehicle, after self-admin	0.6	0.6	0.8	-0.6	0.6	0.9	0.9	-0.9	-0.9
Time to tail flick, test, before self-admin	0.5	0.4	0.7	-0.4	0.4	0.7	0.8	-0.8	-0.9
Time to tail flick, test, after self-admin	0.1	0.1	0.1	0.4	-0.4	-0.3	-0.3	0.3	0.3
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.2	-0.0	0.0	0.4	0.3	-0.3	-0.3
Delta time to tail flick, test, before/after SA	0.1	0.1	0.2	0.1	-0.1	-0.3	-0.4	0.4	0.5
Tibia length	0.9	2.5	5.3	-2.3	2.3	0.8	0.9	-0.9	-1.5
Ambulatory time before self-admin	1.4	1.5	2.7	-1.6	1.6	0.8	1.0	-1.0	-1.0
Ambulatory time after self-admin	0.1	0.1	0.4	-0.6	0.6	0.0	0.2	-0.2	-0.1
Bone: tissue strength	0.2	0.2	0.6	0.2	-0.2	-0.4	-0.3	0.3	0.7
Total heroin consumption	3.6	4.2	4.7	-2.2	2.2	2.0	1.9	-1.9	-2.1
Bone: trabecular number	0.4	0.6	1.2	-1.1	1.1	0.5	0.4	-0.4	-0.8
Bone: trabecular spacing	0.1	0.1	0.3	0.5	-0.5	0.0	0.0	-0.0	0.6
Bone: trabecular thickness	0.4	0.5	0.8	0.5	-0.5	-0.9	-0.8	0.8	0.8
Bone: trabecular tissue density	4.5	6.4	7.1	2.6	-2.6	-2.4	-2.7	2.7	2.2
Water consumed over 24 hours	0.6	0.8	0.9	-0.8	0.8	1.0	0.9	-0.9	-0.8
Number of responses in last shaping day	0.0	0.0	0.1	0.2	-0.2	0.3	0.1	-0.1	-0.1