Hub : Genes

Slc22a6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	OFC	isoform ratio	XM_006230978.4	0.13	0.09	7.5e-03	0.07	0.03	-0.01	0.05	8.5e-03	6.4e-02	7.1e-01	2.7e-02
2	PL	mRNA stability	Slc22a6	0.04	0.02	1.4e-04	0.04	0.03	0.03	0.03	6.4e-05	1.3e-04	1.1e-04	1.1e-04
3	Brain	mRNA stability	Slc22a6	0.13	0.07	5.6e-11	0.1	0.1	0.11	0.1	1.8e-09	1.4e-09	4.5e-10	5.7e-10
4	pVTA	mRNA stability	Slc22a6	0.04	0.03	3.9e-03	0.04	0.04	0.02	0.03	6.9e-04	8.2e-04	5.3e-03	1.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.4	0.8	1.8	0.7	-0.7	-0.6	-1.3
Area under the delay curve	0.2	0.3	0.9	0.0	-0.4	-0.4	-0.9
BMI with tail	2.9	10.2	19.9	2.7	-2.6	-2.7	-4.5
BMI without tail	0.4	2.3	4.2	1.0	-1.4	-1.4	-2.1
Body weight	3.2	14.2	15.3	3.9	-3.8	-3.8	-3.6
Weight adjusted by age	0.3	0.8	1.5	1.2	-0.7	-1.0	-0.6
Bone surface	1.7	3.4	4.5	2.1	-1.7	-1.6	-1.8
Bone volume	0.7	1.5	2.4	1.3	-1.0	-0.9	-1.5
Breakpoint value in progressive ratio session	0.9	1.7	2.8	1.7	-1.4	-1.4	0.4
Number of licking bursts	0.0	0.1	0.2	0.3	-0.4	-0.1	-0.2
Context. condit. distance diff. score	0.4	0.5	1.1	-0.9	0.0	0.4	-1.1
Locomotion velocity, session 1	0.2	0.2	0.4	-0.3	-0.4	-0.3	-0.7
Locomotion distance, session 1	0.9	1.2	2.1	0.4	-1.2	-0.9	-1.4
Locomotion velocity, session 2	2.0	2.4	3.3	1.6	-1.8	-1.6	-1.1
Locomotion distance, session 2	0.3	0.4	0.9	0.3	-0.9	-0.6	-0.4
Locomotion velocity, session 3	1.2	1.4	4.1	0.4	-0.9	-0.7	-2.0
Locomotion distance, session 3	0.1	0.2	0.3	0.3	-0.4	-0.5	-0.4
Stereotopy head waving bouts, day 3	0.7	0.8	2.7	-0.5	-0.2	0.4	-1.6
Stereotopy head waving duration, day 3	0.4	0.4	1.2	-0.6	-0.4	0.3	-1.1
Locomotion velocity, session 7	0.2	0.2	0.6	-0.1	-0.4	0.2	-0.8
Locomotion distance, session 7	0.3	0.3	1.2	-0.3	-0.2	-0.1	-1.1
Stereotopy head waving bouts, day 7	0.1	0.2	0.3	0.4	-0.5	-0.0	-0.6
Stereotopy head waving duration, day 7	1.2	1.4	2.0	1.4	-1.4	-1.1	-0.8
Locomotion velocity, session 8	0.1	0.1	0.2	-0.5	-0.4	-0.1	0.1
Locomotion distance, session 8	0.6	0.8	2.1	-0.9	-0.0	0.5	-1.5
Degree of sensitization distance	0.7	0.8	3.1	-0.2	-0.1	0.2	-1.8
Degree of sensitization stereotypy	0.5	0.5	1.2	1.1	-0.8	-0.5	-0.4
Conditioned locomotion	0.5	0.6	0.8	0.8	-0.9	-0.8	-0.3
Cocaine response after cond. corrected	0.3	0.4	1.3	-1.2	0.1	0.4	-0.5
Cocaine response after cond. not corrected	0.2	0.3	0.8	-0.9	0.4	0.3	-0.4
Cocaine response before conditioning	0.3	0.3	0.9	0.9	0.4	-0.3	0.4
Saline control response	2.7	3.8	5.1	2.3	-2.2	-2.2	-0.6
Bone: connectivity density	1.7	2.7	3.1	1.6	-1.5	-1.6	-1.8
Bone: cortical apparent density	0.3	0.5	0.8	0.4	-0.9	-0.5	0.9
Bone: cortical area	0.6	1.0	2.0	1.4	-0.9	-0.9	-0.7
Bone: cortical porosity	0.4	0.4	1.5	-0.3	-0.1	0.3	1.2
Bone: cortical porosity	0.2	0.2	0.9	-0.0	-0.4	-0.0	0.9
Bone: cortical thickness	2.7	4.6	6.2	2.5	-2.3	-2.5	0.7
Bone: cortical thickness	0.5	0.6	1.0	0.6	-0.8	-1.0	0.5
Bone: cortical tissue density	0.4	0.7	1.1	0.6	-1.0	-0.7	0.9
Condit. Reinf. active minus inactive responses	0.8	0.9	1.2	1.1	-0.9	-1.1	-0.4
Condit. Reinf. active-inactive response ratio	0.3	0.4	0.6	0.5	-0.7	-0.8	0.2
Condit. Reinf. active responses	0.6	0.7	1.1	1.1	-0.6	-0.7	-0.9
Condit. Reinf. inactive responses	0.3	0.4	1.1	0.1	0.6	0.4	-1.0
Incentive salience index mean	1.1	1.5	1.8	1.3	-1.1	-1.2	-1.2
Condit. Reinf. lever presses	1.0	1.5	2.4	1.3	-1.0	-1.0	-1.5
Condit. Reinf. active minus inactive responses	0.2	0.3	0.6	-0.2	0.5	0.7	0.7
Condit. Reinf. active-inactive response ratio	0.5	0.8	1.9	-0.6	0.9	1.4	-0.1
Condit. Reinf. active responses	0.1	0.1	0.2	0.4	-0.3	-0.2	0.3
Condit. Reinf. inactive responses	0.3	0.5	1.0	0.5	-0.7	-1.0	0.3
Condit. Reinf. lever presses	0.7	1.0	2.0	1.4	-0.7	-0.9	-0.7
Condit. Reinf. lever reinforcers received	0.2	0.2	0.4	0.6	-0.5	-0.3	0.4
Conditioned reinforcement - actives	0.2	0.6	1.2	-0.5	1.1	0.9	0.3
Conditioned reinforcement - inactives	0.2	0.4	0.9	-0.3	0.7	0.6	-0.9
Conditioned locomotion	1.7	2.5	3.5	-1.9	1.7	1.8	-0.7
Patch foraging indifference point 0 sec	0.3	0.8	1.5	0.8	-1.2	-0.9	-0.5
Patch foraging indifference point AUC	0.4	0.9	1.9	1.4	-0.9	-0.7	0.5
Delay disc. indifference point, 0s delay	0.4	0.5	1.3	-0.7	0.3	0.3	-1.1
Delay disc. indifference point, 16s delay	0.1	0.2	0.6	0.3	-0.2	-0.2	-0.8
Delay disc. indifference point, 2s delay	0.4	0.4	0.8	-0.6	0.6	0.5	-0.9
Delay disc. indifference point, 24s delay	0.1	0.2	0.3	0.1	-0.5	-0.6	-0.4
Delay disc. indifference point, 4s delay	0.8	0.8	1.3	0.3	-1.0	-0.9	-1.1
Delay disc. indifference point, 8s delay	0.1	0.2	0.6	-0.8	0.1	0.3	-0.0
Indifference point function ln k	0.9	2.7	6.6	-2.6	1.5	1.3	-0.7
Indifference point function log k	0.9	2.7	6.6	-2.6	1.5	1.3	-0.7
Patch foraging total patch changes 0 sec	0.3	0.9	1.7	0.9	-1.3	-1.1	-0.3
Patch foraging total patch changes 12 sec	4.3	5.7	8.7	2.8	-2.9	-2.5	-0.1
Patch foraging total patch changes 18 sec	0.2	0.6	0.8	0.9	-0.9	-0.6	0.6
Patch foraging total patch changes 24 sec	2.1	7.3	10.0	3.0	-3.2	-2.9	-1.3
Patch foraging total patch changes 6 sec	1.1	1.8	2.9	1.3	-1.7	-1.5	-0.7
Patch foraging time to switch 0 sec	0.1	0.4	1.2	0.6	-0.3	-0.2	-1.1
Patch foraging water rate 0 sec	0.1	0.4	0.7	-0.8	0.5	0.5	0.8
Patch foraging water rate 12 sec	0.3	1.4	3.2	-1.8	1.2	0.9	0.4
Patch foraging water rate 18 sec	0.1	0.3	0.6	-0.6	0.2	-0.1	-0.8
Patch foraging water rate 24 sec	0.7	1.0	2.0	-1.4	1.0	0.9	0.4
Patch foraging water rate 6 sec	0.5	0.7	1.6	-1.3	0.8	0.7	0.3
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.2	0.4	-0.2	-0.2	-0.5
Distance traveled before self-admin	0.9	1.9	3.3	1.8	-1.4	-1.3	-0.9
Distance traveled after self-admin	0.2	0.4	0.7	0.9	-0.6	-0.7	0.4
Extensor digitorum longus weight	5.7	22.7	30.0	5.5	-5.2	-5.1	-2.7
Bone: elastic displacement	0.4	0.5	1.3	-0.7	0.4	0.3	1.1
Bone: elastic work	0.9	1.2	2.2	1.1	-1.2	-1.5	-0.1
Bone: endosteal estimation	1.2	3.0	5.4	-1.3	1.6	1.6	-2.3
Bone: endosteal perimeter	1.7	4.1	5.0	-1.6	2.1	2.2	-2.1
Epididymis fat weight	0.5	2.5	3.7	-1.1	1.9	1.7	-1.4
Delta time in closed arm before/after self-admin	1.6	1.5	2.4	0.8	-1.5	-1.5	-0.9
Delta time in open arm before/after self-admin	0.9	1.0	2.2	1.5	-1.0	-0.9	-0.3
Diff in mean of infusions in LGA sessions	1.4	2.4	3.8	1.7	-2.0	-1.7	-0.0
Delay discount exponential model param	0.2	0.3	0.8	-0.0	0.5	0.4	0.9
Extinction: sum of active levers before priming	2.3	3.5	4.5	2.1	-2.1	-2.0	-1.1
Active lever presses in extinction session 6	1.6	1.6	3.0	1.7	-1.3	-1.3	-0.3
Bone: final force	1.5	2.4	3.3	1.8	-1.4	-1.4	-1.5
Bone: final moment	1.6	2.5	3.5	1.9	-1.5	-1.5	-1.5
Food consumed during 24 hour testing period	0.1	0.2	0.3	0.1	0.5	0.4	0.5
Glucose	1.7	2.7	3.8	-1.9	1.8	1.7	-0.9
Heart weight	0.6	1.0	3.6	-0.6	0.3	0.0	-1.9
Delay discount hyperbolic model param	0.2	0.2	0.8	0.1	0.3	0.2	0.9
Intermittent access intake day 1-15 change	0.5	2.5	3.8	-1.2	1.9	1.8	1.1
Intermittent access intake escalation	0.6	3.1	4.6	-1.4	2.1	2.0	1.3
Intermittent access intake escalation 2	0.6	1.0	1.6	-0.6	1.3	1.2	0.7
Intermitt. access day 1 inactive lever presses	0.1	1.7	2.3	-1.3	1.4	1.5	1.0
Intermitt. access day 15 inactive lever presses	0.2	0.8	2.4	0.8	-0.2	-0.4	-1.6
Intermitt. access escalation Index	0.2	0.5	0.8	-0.9	0.7	0.7	0.6
Intermittent access day 1 total infusions	0.7	2.2	6.7	-0.8	0.9	0.8	-2.6
Intermittent access day 15 total infusions	1.9	4.6	7.2	-2.1	2.7	2.5	-0.7
Intermittent access terminal intake (last 3 days)	1.3	2.4	2.9	-1.1	1.7	1.5	-1.7
Intermittent access total infusions	1.9	2.3	3.5	-1.2	1.5	1.4	-1.9
Intermittent access day 1 locomotion	0.6	1.2	4.3	-0.3	0.3	0.3	-2.1
Intermittent access day 15 total locomotion	0.3	1.1	2.5	-0.5	0.9	0.8	-1.6
Intermittent access total locomotion	2.0	2.4	7.3	-0.6	1.0	0.9	-2.7
Intermittent access standard deviation	0.2	1.2	2.2	-1.0	1.5	1.3	0.3
Left kidney weight	0.1	1.0	2.3	-0.5	0.8	0.8	-1.5
Right kidney weight	0.1	0.4	1.0	-0.2	0.6	0.6	-1.0
Cocaine induced anxiety	0.0	0.1	0.2	0.1	0.1	0.1	0.5
Post-drug Anxiety	0.2	0.2	0.3	0.6	-0.4	-0.5	-0.0
Baseline Anxiety	0.4	0.6	0.9	0.6	-0.9	-0.9	-0.5
Tail length	0.3	1.5	2.1	1.2	-1.5	-1.3	0.7
Length with tail	1.3	5.6	7.8	2.8	-2.8	-2.6	-0.4
Length without tail	1.7	9.0	12.0	3.5	-3.5	-3.3	-1.1
Times rat made contact with spout	0.3	0.4	0.5	0.4	-0.7	-0.6	0.6
Lifetime Intake	1.4	1.8	3.2	-1.1	1.3	1.1	-1.8
Liver weight, left	0.7	1.3	1.7	-1.2	1.3	1.2	0.7
Liver weight, right	0.7	1.3	2.2	-1.5	1.2	1.1	-0.5
Locomotor activity	0.3	0.5	1.2	-1.1	0.6	0.3	0.7
Locomotor testing distance	0.2	0.5	1.4	-1.2	0.7	0.3	0.4
Locomotor testing rearing	0.2	0.8	1.4	-1.2	1.0	0.6	0.5
Locomotion in novel chamber	1.6	2.1	3.5	-1.4	1.9	1.7	-0.2
Locomotion in novel chamber post-restriction	0.8	2.4	3.8	-1.7	1.6	1.9	0.7
Fecal boli incidents, locomotor time 1	0.2	0.5	1.0	-0.4	0.9	1.0	0.4
Change in fecal boli incidents, locomotor task	0.5	0.5	1.4	-1.2	0.5	0.6	-0.1
Time >=10cm from walls, locomotor time 1	1.8	2.2	3.8	-1.4	1.7	2.0	-0.3
Bouts of movement, locomotor time 1	0.9	1.2	4.4	0.5	-0.2	-0.1	2.1
Total resting periods, locomotor time 1	0.7	0.8	3.1	0.4	-0.1	-0.0	1.8
Rest time, locomotor task time 1	1.2	2.0	2.3	-1.5	1.5	1.5	1.2
Distance moved, locomotor task time 1	0.2	0.5	0.8	0.5	-0.5	-0.7	-0.9
Vertical activity count, locomotor time 1	0.0	0.3	0.5	-0.7	0.6	0.6	-0.1
Time >=10cm from walls, locomotor time 2	0.1	0.3	0.5	-0.1	0.6	0.7	0.7
Bouts of movement, locomotor time 2	0.3	1.1	2.0	1.4	-1.0	-1.1	-0.0
Total resting periods, locomotor time 2	0.1	0.5	1.0	1.0	-0.6	-0.7	0.0
Rest time, locomotor task time 2	1.7	2.9	4.5	-2.1	1.7	2.0	0.7
Distance moved, locomotor task time 2	0.3	0.4	0.6	0.8	-0.5	-0.8	0.6
Vertical activity count, locomotor time 2	0.1	0.2	0.9	-0.0	-0.1	-0.3	1.0
Light reinforcement 1	0.0	0.1	0.4	-0.0	0.3	0.1	0.6
Light reinforcement 2	0.2	0.5	1.0	0.0	1.0	1.0	-0.4
Bone: marrow area	1.3	3.3	5.1	-1.5	1.7	1.7	-2.2
Bone: maximum diameter	0.2	0.4	1.3	0.6	-0.1	0.1	-1.2
Bone: maximum force	2.2	4.3	6.4	2.3	-1.6	-1.7	-2.5
Bone: maximum moment	2.3	4.3	5.9	2.4	-1.6	-1.8	-2.4
Mean time between licks in bursts	0.1	0.9	2.1	0.6	-0.8	-1.4	-0.6
Mean num. licks in bursts	0.1	0.2	0.5	-0.3	0.2	-0.0	0.7
Cd content in liver	0.9	1.0	1.7	-1.2	0.8	1.3	0.3
Co content in liver	0.9	1.0	2.4	-1.1	0.5	0.5	1.5
Cu content in liver	0.1	0.1	0.3	-0.1	-0.0	-0.0	0.6
Fe content in liver	0.0	0.0	0.1	-0.3	-0.0	0.1	-0.2
K content in liver	0.7	0.6	1.0	0.8	-0.6	-0.7	-1.0
Mg content in liver	0.4	0.4	1.3	0.1	-0.5	-0.4	-1.1
Mn content in liver	2.5	2.8	4.6	2.2	-1.8	-1.7	-0.6
Na content in liver	0.3	0.4	0.6	0.8	-0.5	-0.6	-0.6
Rb content in liver	1.5	1.8	3.1	-1.8	1.4	1.4	0.4
Se content in liver	0.0	0.1	0.1	0.4	0.0	0.1	-0.3
Sr content in liver	3.4	2.9	4.2	2.0	-2.1	-1.8	-0.2
Zn content in liver	2.3	2.7	4.3	1.7	-2.1	-1.7	-0.9
Bone: minimum diameter	1.0	1.9	4.4	-0.8	1.2	1.2	-2.1
Time in familiar zone, hab. session 1	0.2	0.2	0.5	0.3	-0.1	-0.4	-0.7
Time in novel zone, hab. session 1	0.9	1.0	1.5	-1.2	1.0	0.9	0.8
Total zone transitions, hab. session 1	0.3	0.4	1.0	0.5	-1.0	-0.5	0.0
Total locomotion distance, hab. session 1	0.2	0.3	0.7	-0.3	-0.1	0.5	-0.9
Locomotion velocity, hab. session 1	0.2	0.3	0.5	0.3	-0.7	-0.1	-0.7
Time in familiar zone, hab. session 2	0.4	0.4	1.1	-0.3	0.7	-0.1	1.0
Time in novel zone, hab. session 2	0.6	0.7	1.5	0.6	-0.8	-0.5	-1.2
Total zone transitions, hab. session 2	1.6	2.0	2.7	1.2	-1.6	-1.5	-1.3
Total locomotion distance, hab. session 2	0.4	0.5	1.3	0.3	-0.7	-0.4	-1.1
Locomotion velocity, hab. session 2	0.3	0.5	1.6	0.1	-0.5	-0.1	-1.2
Novel to familiar place preference ratio	1.1	1.5	2.5	1.6	-1.2	-1.1	-0.7
Novelty place preference	0.6	0.8	1.6	1.3	-0.9	-0.8	-0.6
Time in novel zone, NPP test	0.8	0.9	1.6	1.3	-0.9	-0.9	-0.7
Total zone transitions, NPP test	1.1	1.6	2.9	1.0	-1.7	-1.3	-0.8
Total locomotion distance, NPP test	0.2	0.3	0.6	-0.0	-0.7	-0.3	-0.8
Locomotion velocity, NPP test	0.1	0.1	0.3	-0.1	-0.6	-0.1	-0.4
Intraocular pressure	0.3	0.5	1.6	-0.3	0.5	0.5	1.2
Delta distance traveled before/after self-admin	0.3	0.3	0.7	-0.7	0.3	0.2	0.8
Delta ambulatory time before/after self-admin	0.3	0.6	1.1	-0.9	0.5	0.4	1.0
Parametrial fat weight	1.5	3.6	5.0	-1.8	2.1	2.2	-1.4
Pavlov. Cond. lever latency	1.0	1.3	1.8	-1.3	0.9	1.0	1.4
Pavlov. Cond. magazine entry latency	0.8	1.0	1.7	1.3	-0.5	-0.7	-1.3
Pavlov. Cond. change in total contacts	0.2	0.2	0.5	0.7	-0.2	-0.0	-0.5
Pavlov. Cond. index score	0.5	0.6	1.3	1.1	-0.5	-0.6	-0.6
Pavlov. Cond. latency score	0.5	0.7	1.1	1.0	-0.5	-0.7	-0.9
Pavlov. Cond. lever contacts	0.6	0.7	1.5	0.9	-0.5	-0.6	-1.2
Pavlov. Cond. magazine entry number	0.4	0.5	1.4	-1.2	0.5	0.6	0.1
Pavlov. Cond. intertrial magazine entries	0.3	0.3	1.1	0.1	0.3	0.3	1.1
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	1.4	1.2	-0.5	-0.6	-0.7
Pavlov. Cond. response bias	0.6	0.7	1.7	1.3	-0.6	-0.7	-0.6
Pavlov. Cond. lever latency	0.4	0.6	1.2	-1.1	0.4	0.7	0.7
Pavlov. Cond. magazine entry latency	3.0	4.2	7.5	2.7	-1.9	-2.3	-0.6
Pavlov. Cond. change in total contacts	0.5	1.1	2.9	1.7	-0.7	-1.0	-0.5
Pavlov. Cond. index score	1.4	2.3	4.7	2.2	-1.1	-1.6	-0.8
Pavlov. Cond. latency score	1.3	2.0	4.2	2.0	-1.1	-1.4	-0.9
Pavlov. Cond. lever contacts	0.3	0.4	1.0	1.0	-0.2	-0.6	-0.4
Pavlov. Cond. magazine entry number	4.8	6.3	11.1	-3.3	2.4	2.7	0.7
Pavlov. Cond. intertrial magazine entries	0.9	1.9	2.7	-1.6	1.2	1.6	1.0
Pavlov. Cond. lever-magazine prob. diff.	1.7	2.6	5.4	2.3	-1.2	-1.7	-0.7
Pavlov. Cond. response bias	1.5	2.0	3.9	2.0	-1.1	-1.6	-0.8
Time in closed arm before self-admin	0.1	0.2	0.4	-0.0	0.6	0.5	-0.2
Time in closed arm after self-admin	0.5	0.6	1.0	-1.0	0.9	0.7	0.0
Time in open arm before self-admin	0.3	0.3	1.2	-1.1	0.1	0.1	0.3
Time in open arm after self-admin	0.5	0.6	1.1	0.7	-1.1	-0.9	0.1
Bone: periosteal estimation	0.4	1.1	3.9	0.1	0.4	0.4	-2.0
Bone: periosteal perimeter	0.2	0.5	1.6	0.2	0.3	0.4	-1.3
Bone: post-yield work	1.2	2.0	7.0	-0.2	0.7	0.7	-2.6
Progressive ratio test 1 active lever presses	0.3	0.6	0.7	-0.9	0.8	0.8	-0.6
Progressive ratio test 1 breakpoint	0.3	0.6	0.7	-0.9	0.8	0.8	-0.5
Progressive ratio test 1 inactive lever presses	0.2	0.7	1.3	0.7	-0.6	-0.7	-1.1
Progressive ratio test 2 active lever presses	1.0	1.5	2.1	-1.1	1.4	1.3	-0.8
Progressive ratio test 2 breakpoint	1.1	1.4	1.9	-1.1	1.4	1.3	-0.9
Progressive ratio test 2 inactive lever presses	0.4	1.3	1.7	-1.0	1.3	1.2	-1.0
Incentive Sensitization - Responses	0.3	0.8	2.3	0.8	-0.3	-0.5	-1.5
Incentive Sensitization - Breakpoint	0.3	0.7	2.3	0.6	-0.2	-0.3	-1.5
Sum of active levers in priming session hrs 5-6	0.7	0.7	1.4	1.0	-0.3	-0.2	1.2
Progressive ratio	0.2	0.5	1.7	0.3	0.3	0.1	-1.3
Food seeking constrained by brief footshock	0.0	0.0	0.0	-0.1	0.0	0.1	-0.2
Seeking ratio, punishment vs. effort	0.1	0.2	0.2	-0.4	-0.4	-0.3	0.4
Retroperitoneal fat weight	2.7	11.9	16.1	-4.0	4.0	3.9	-0.6
Reaction time number correct	0.2	0.7	1.4	1.1	-0.7	-1.2	-0.0
Reaction time mean minus median	0.1	0.4	0.8	0.9	-0.2	-0.0	0.8
Reaction time mean minus median AUC	0.1	0.5	1.8	0.5	0.0	0.0	1.4
Reaction time num false alarms	0.2	0.3	0.6	-0.8	0.0	-0.1	0.8
Reaction time num false alarms AUC	0.2	0.4	0.7	-0.3	-0.6	-0.6	0.9
Reaction time trials correct on left	0.2	0.7	1.4	1.1	-0.7	-1.2	-0.0
Reaction time trials on left	0.2	0.8	1.4	1.1	-0.7	-1.2	0.1
Reaction time mean	0.2	0.3	0.6	-0.2	0.6	0.6	0.8
Reaction time mean AUC	0.2	0.5	0.7	-0.2	0.8	0.7	0.8
Median of all reaction times	0.1	0.1	0.2	-0.2	0.4	0.4	0.4
Reaction time omissions	0.3	0.5	1.1	0.6	-0.5	-0.4	1.1
Reaction time false alarm rate	0.2	0.3	0.8	-0.9	-0.0	0.1	0.5
Reaction time premature initiation rate	4.2	6.5	8.8	2.6	-2.7	-3.0	-1.8
Reaction time premature initiations	2.6	7.9	11.8	3.1	-2.9	-3.4	-1.2
Std. dev. reaction times	0.2	0.8	2.3	-0.2	0.5	0.7	1.5
Reaction time trials completed	0.2	0.8	1.4	1.1	-0.7	-1.2	0.1
Reaction time trials AUC	0.2	0.7	1.3	1.0	-0.6	-1.1	-0.0
Run reversals in cocaine runway, females	1.2	1.4	3.0	0.6	-1.1	-1.1	-1.7
Run reversals in cocaine runway, males	0.4	0.4	0.6	-0.8	0.3	0.7	0.8
Latency to leave start box in cocaine runway	0.4	0.6	0.9	-0.7	0.8	0.6	-1.0
Latency to leave start box in cocaine runway, F	0.1	0.1	0.4	0.2	-0.1	-0.2	-0.6
Latency to leave start box in cocaine runway, M	1.8	1.7	2.5	-1.6	1.5	1.3	-0.4
Std. dev. time between licks in bursts	0.0	0.1	0.2	-0.2	0.1	-0.4	-0.1
Total sessions with >9 infusions	0.7	0.8	1.1	-1.0	1.1	1.0	-0.5
Short access day 1 total inactive lever presses	0.2	0.4	1.5	-0.3	0.1	0.1	-1.2
Short access day 10 total inactive lever presses	0.1	0.6	0.9	-1.0	0.7	0.8	0.6
Short access day 1 total infusions	0.7	1.3	1.8	-1.3	1.3	1.2	-0.7
Short access day 10 total infusions	0.8	1.3	4.0	-0.5	0.7	0.6	-2.0
Short access total infusions	0.8	1.2	2.6	-0.9	0.8	0.7	-1.6
Short access day 1 locomotion	0.3	0.4	0.7	-0.5	0.7	0.6	-0.8
Short access day 10 total locomotion	0.2	0.8	3.0	0.2	-0.0	0.1	-1.7
Short access total locomotion	0.4	0.6	2.0	-0.3	0.5	0.5	-1.4
One hour access (0.3 mA shock)	1.3	1.5	1.8	-1.2	1.4	1.3	-1.1
Compulsive drug intake	0.9	1.3	1.8	1.0	-1.3	-1.3	0.8
One hour access (shock baseline)	1.6	4.3	6.1	-2.1	2.5	2.5	-0.7
Social response proportion	0.1	0.1	0.2	0.4	0.0	-0.3	-0.1
Social responses	0.3	0.4	1.1	0.4	-0.2	-0.4	1.1
Social time	0.1	0.2	0.8	0.0	-0.3	-0.1	0.9
Soleus weight	2.2	6.4	9.3	-3.0	2.8	2.8	0.9
Bone: stiffness	0.4	0.7	1.7	1.3	-0.5	-0.6	-0.9
Tibialis anterior weight	7.2	24.7	34.8	5.9	-5.8	-5.3	-1.4
Time to tail flick, vehicle, before self-admin	0.4	0.5	1.8	0.3	-0.2	-0.1	-1.3
Time to tail flick, vehicle, after self-admin	0.3	0.6	1.3	0.4	-0.7	-0.7	-1.2
Time to tail flick, test, before self-admin	1.3	1.5	4.3	0.5	-0.9	-0.8	-2.1
Time to tail flick, test, after self-admin	0.0	0.0	0.0	0.2	0.1	0.1	0.1
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.5	0.3	-0.7	-0.6	-0.1
Delta time to tail flick, test, before/after SA	0.8	1.0	3.7	0.0	0.5	0.4	1.9
Tibia length	0.8	2.3	4.6	2.1	-1.7	-1.1	-0.7
Ambulatory time before self-admin	0.5	1.4	2.8	1.7	-1.1	-1.1	-0.6
Ambulatory time after self-admin	0.1	0.1	0.3	0.6	-0.2	-0.3	-0.0
Bone: tissue strength	0.1	0.1	0.4	-0.2	0.6	0.3	0.2
Total heroin consumption	4.5	5.3	7.4	2.7	-2.7	-2.5	0.3
Bone: trabecular number	1.0	1.9	3.1	1.3	-1.2	-1.2	-1.7
Bone: trabecular spacing	0.6	0.8	1.7	-0.8	0.8	0.4	1.3
Bone: trabecular thickness	0.2	0.2	0.4	-0.4	0.6	0.6	-0.1
Bone: trabecular tissue density	3.8	6.7	9.1	-3.0	2.5	2.8	2.0
Water consumed over 24 hours	0.5	0.9	1.2	1.1	-1.0	-1.1	0.2
Number of responses in last shaping day	0.2	0.2	0.3	0.4	-0.6	-0.5	-0.2