Sdhaf2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Sdhaf2	0.35	0.1	2.0e-09	0.01	0.08	0.08	0.06	9.1e-03	1.6e-09	1.3e-09	5.8e-07
2	Brain	gene expression	Sdhaf2	0.04	0.02	1.0e-03	0.03	0.03	0.03	0.02	7.4e-04	1.9e-03	1.5e-03	2.8e-03
3	Liver	gene expression	Sdhaf2	0.22	0.09	5.1e-12	0.09	0.09	0.08	0.08	1.1e-09	2.7e-10	4.8e-09	5.7e-09
4	BLA	gene expression	Sdhaf2	0.1	0.06	4.5e-05	0.07	0.07	0.03	0.05	1.1e-04	1.1e-04	8.3e-03	9.9e-04
5	Liver	intron excision ratio	chr1_207144368_207161731	0.05	0.03	1.1e-04	0.03	0.02	0.02	0.01	7.7e-04	9.6e-04	2.7e-03	8.7e-03
6	Brain	alternative polyA	NM_001008371.1	0.04	0.04	7.7e-03	0.01	0.02	0.01	0.01	7.7e-02	4.6e-03	2.6e-02	2.8e-02
7	PL	gene expression	Sdhaf2	0.06	0.04	9.4e-05	0.03	0.02	0.02	0.02	1.6e-04	1.2e-03	2.1e-03	3.2e-03
8	Adipose	mRNA stability	Sdhaf2	0.03	0.02	4.9e-03	0.01	0.01	0	0.01	2.0e-02	1.6e-02	2.1e-01	2.1e-02
9	Brain	alternative polyA	NM_001008371.1	0.04	0.03	9.3e-03	0	0.02	0.01	0.01	1.2e-01	6.4e-03	3.6e-02	3.9e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9
Bone: apparent density	0.2	0.3	0.8	0.5	-0.0	-0.3	0.0	-0.9	0.6	0.1	0.9	0.6
Area under the delay curve	0.5	0.6	1.6	-1.2	-0.2	0.1	-0.3	-1.3	0.5	-0.4	1.0	0.5
BMI with tail	2.6	8.3	15.1	0.9	3.0	-3.7	3.1	-1.0	3.9	2.7	1.8	3.9
BMI without tail	0.9	1.9	2.9	0.7	1.6	-1.6	1.7	0.6	1.6	1.5	0.1	1.6
Body weight	2.2	9.0	16.3	1.8	3.3	-3.3	3.0	0.2	4.0	3.7	0.6	4.0
Weight adjusted by age	3.8	4.3	6.8	2.3	2.5	-2.6	2.6	1.5	1.9	2.0	-0.6	1.9
Bone surface	0.5	0.8	1.9	-0.1	0.6	-1.0	0.6	-1.0	1.4	0.4	0.9	1.4
Bone volume	0.3	0.5	1.4	0.4	0.1	-0.5	0.1	-1.2	0.9	0.5	1.1	0.9
Breakpoint value in progressive ratio session	2.2	2.4	3.7	1.9	1.7	-1.2	1.8	1.9	0.8	1.5	-1.8	0.8
Number of licking bursts	0.1	0.1	0.4	-0.1	0.1	-0.0	-0.1	-0.3	0.4	0.6	0.5	0.4
Context. condit. distance diff. score	0.0	0.0	0.2	0.3	0.0	-0.1	0.1	0.2	0.1	0.2	0.4	0.2
Locomotion velocity, session 1	0.2	0.2	0.4	-0.1	0.6	-0.6	0.6	0.4	0.0	-0.2	-0.5	-0.0
Locomotion distance, session 1	1.0	1.2	2.4	1.1	1.4	-1.5	1.4	0.5	1.1	1.0	-0.3	1.0
Locomotion velocity, session 2	2.4	2.8	4.1	1.9	2.0	-2.0	1.9	0.6	2.0	1.3	-0.1	1.9
Locomotion distance, session 2	0.9	1.2	2.1	0.9	1.3	-1.2	1.3	0.8	0.9	1.4	-0.6	0.9
Locomotion velocity, session 3	1.4	1.6	3.1	0.8	0.7	-1.3	0.8	-1.2	1.7	0.8	1.7	1.8
Locomotion distance, session 3	0.2	0.2	0.4	-0.4	-0.6	0.5	-0.6	-0.4	-0.2	-0.5	0.4	-0.2
Stereotopy head waving bouts, day 3	0.6	0.7	1.9	-0.5	0.2	-0.7	0.3	-1.3	0.9	-0.1	1.4	0.9
Stereotopy head waving duration, day 3	0.3	0.4	0.9	-0.4	0.3	-0.5	0.4	-0.7	0.9	0.1	1.0	0.9
Locomotion velocity, session 7	0.3	0.4	1.1	-0.8	-0.4	0.2	-0.4	-1.1	0.5	-0.4	0.8	0.5
Locomotion distance, session 7	0.2	0.3	1.0	-1.0	-0.4	0.3	-0.4	-0.5	0.1	-0.4	0.7	0.2
Stereotopy head waving bouts, day 7	0.3	0.3	0.6	-0.2	0.6	-0.8	0.6	-0.4	0.8	0.3	0.3	0.8
Stereotopy head waving duration, day 7	0.8	1.0	1.8	0.6	1.2	-1.2	1.2	0.1	1.3	0.8	-0.1	1.4
Locomotion velocity, session 8	0.4	0.5	2.1	-1.4	-0.3	0.7	-0.3	0.6	-0.6	0.3	-0.7	-0.6
Locomotion distance, session 8	0.2	0.2	0.4	0.1	0.3	-0.6	0.4	-0.4	0.6	0.5	0.7	0.6
Degree of sensitization distance	0.8	0.8	1.3	-0.2	0.8	-1.2	0.8	-0.8	1.2	0.6	1.0	1.2
Degree of sensitization stereotypy	0.7	0.8	1.3	0.6	1.1	-1.2	1.1	0.2	1.0	0.8	-0.2	1.0
Conditioned locomotion	0.4	0.4	0.7	-0.3	0.8	-0.7	0.8	0.4	0.8	-0.2	-0.3	0.9
Cocaine response after cond. corrected	0.1	0.1	0.4	-0.6	0.3	-0.4	0.4	0.3	-0.0	0.2	0.1	-0.0
Cocaine response after cond. not corrected	0.1	0.1	0.3	-0.0	0.3	-0.5	0.4	-0.0	-0.1	-0.1	0.2	-0.1
Cocaine response before conditioning	0.3	0.4	2.8	1.7	0.0	-0.3	0.1	-0.4	-0.1	-0.3	-0.2	-0.2
Saline control response	1.2	1.6	2.5	1.0	1.5	-1.2	1.5	1.2	1.0	1.6	-1.2	1.0
Bone: connectivity density	0.6	0.9	1.9	0.7	0.9	-1.2	0.9	-0.5	1.4	0.3	0.6	1.4
Bone: cortical apparent density	0.5	0.7	3.3	1.8	0.7	-0.4	0.6	0.9	0.2	0.4	-1.0	0.2
Bone: cortical area	0.3	0.5	2.9	1.7	0.3	-0.5	0.3	-0.4	0.5	0.6	0.1	0.5
Bone: cortical porosity	0.3	0.3	1.0	-1.0	0.0	0.3	0.1	0.9	-0.4	-0.1	-0.8	-0.4
Bone: cortical porosity	0.4	0.5	1.5	-1.1	0.3	0.1	0.4	1.2	-0.2	0.1	-1.2	-0.2
Bone: cortical thickness	1.3	2.2	5.9	2.4	1.4	-0.9	1.4	1.8	0.5	1.2	-2.0	0.5
Bone: cortical thickness	0.5	0.6	2.7	1.6	0.2	0.1	0.2	1.1	-0.2	-0.6	-1.0	-0.2
Bone: cortical tissue density	0.6	0.8	3.5	1.9	0.8	-0.5	0.7	1.1	0.3	0.5	-1.1	0.3
Condit. Reinf. active minus inactive responses	1.4	1.6	2.8	1.5	1.6	-1.7	1.6	0.9	0.8	1.3	-0.7	0.8
Condit. Reinf. active-inactive response ratio	1.3	1.4	3.0	1.0	1.4	-1.2	1.4	1.7	0.2	0.9	-1.5	0.1
Condit. Reinf. active responses	1.8	2.2	5.3	2.3	1.7	-2.0	1.7	0.2	1.4	1.2	0.0	1.3
Condit. Reinf. inactive responses	0.8	1.0	2.9	1.7	0.3	-0.8	0.3	-1.2	0.9	0.4	1.3	0.9
Incentive salience index mean	1.1	1.4	3.4	1.8	1.3	-1.6	1.3	0.0	1.1	0.7	0.1	1.1
Condit. Reinf. lever presses	0.5	0.7	1.6	1.2	0.3	-0.7	0.3	-1.1	0.9	-0.5	1.0	0.9
Condit. Reinf. active minus inactive responses	0.1	0.1	0.4	0.6	0.3	-0.5	0.2	-0.2	-0.2	-0.4	-0.1	-0.2
Condit. Reinf. active-inactive response ratio	0.5	0.5	0.9	0.3	0.6	-0.9	0.5	-0.9	0.8	0.4	1.0	0.8
Condit. Reinf. active responses	0.1	0.1	0.6	0.7	0.3	-0.4	0.2	0.2	-0.1	-0.3	-0.2	-0.1
Condit. Reinf. inactive responses	0.5	0.6	1.2	0.2	-0.6	0.7	-0.7	0.4	-1.1	-1.0	-0.7	-1.1
Condit. Reinf. lever presses	1.0	1.4	3.0	1.7	1.2	-1.4	1.1	0.2	1.2	1.2	0.3	1.2
Condit. Reinf. lever reinforcers received	0.3	0.4	1.2	1.1	0.7	-0.8	0.7	0.5	0.2	0.2	-0.5	0.1
Conditioned reinforcement - actives	0.8	0.8	1.8	0.1	-0.9	0.7	-0.9	-0.1	-1.3	-1.3	0.0	-1.3
Conditioned reinforcement - inactives	0.4	0.4	1.3	0.7	-0.4	-0.0	-0.4	-1.0	-0.1	-0.8	1.1	-0.1
Conditioned locomotion	0.8	1.0	2.4	-0.2	-1.1	0.5	-1.1	-1.4	-0.5	-1.2	1.5	-0.5
Patch foraging indifference point 0 sec	0.2	0.3	0.5	0.5	0.5	-0.5	0.6	0.1	0.7	0.4	-0.2	0.7
Patch foraging indifference point AUC	1.4	1.6	4.9	2.2	1.4	-1.4	1.2	0.4	1.2	0.9	-0.7	1.2
Delay disc. indifference point, 0s delay	0.8	0.9	2.5	-1.5	0.2	-0.5	-0.1	-1.3	0.9	0.1	1.6	0.9
Delay disc. indifference point, 16s delay	0.2	0.2	0.7	0.3	0.1	-0.4	0.2	-0.8	0.6	0.2	0.7	0.6
Delay disc. indifference point, 2s delay	1.0	1.1	3.7	-1.7	-0.6	0.3	-0.7	-1.9	0.2	-0.4	1.6	0.2
Delay disc. indifference point, 24s delay	0.1	0.1	0.1	-0.2	-0.1	0.2	-0.2	-0.4	0.2	-0.3	0.4	0.2
Delay disc. indifference point, 4s delay	0.6	0.6	1.9	-1.4	-0.0	0.1	-0.3	-1.1	0.8	-0.0	1.0	0.9
Delay disc. indifference point, 8s delay	1.2	1.2	5.6	-2.4	-0.9	0.9	-0.8	-1.1	-0.2	-1.1	0.6	-0.1
Indifference point function ln k	1.4	2.0	4.9	-2.2	-1.5	1.1	-1.5	-1.3	-1.0	-1.0	1.8	-1.0
Indifference point function log k	1.4	2.0	4.9	-2.2	-1.5	1.1	-1.5	-1.3	-1.0	-1.0	1.8	-1.0
Patch foraging total patch changes 0 sec	0.1	0.2	0.3	0.6	0.4	-0.3	0.5	0.4	0.5	0.2	-0.5	0.5
Patch foraging total patch changes 12 sec	3.7	4.8	7.8	2.8	2.5	-2.1	2.5	2.0	2.0	1.8	-1.8	2.0
Patch foraging total patch changes 18 sec	0.2	0.3	0.8	0.5	0.6	-0.4	0.4	0.5	0.3	0.4	-0.9	0.2
Patch foraging total patch changes 24 sec	4.7	5.7	8.8	2.9	2.6	-2.5	2.5	0.8	3.0	2.3	-0.4	3.0
Patch foraging total patch changes 6 sec	0.3	0.5	1.0	1.0	0.6	-0.6	0.6	-0.0	1.0	0.6	0.0	1.0
Patch foraging time to switch 0 sec	0.4	0.6	1.0	-0.6	0.5	-0.9	0.8	-0.6	1.0	0.4	0.8	1.0
Patch foraging water rate 0 sec	0.6	1.0	1.6	0.9	-1.1	1.2	-1.1	0.1	-1.3	-0.8	-0.4	-1.3
Patch foraging water rate 12 sec	0.7	1.1	2.2	-0.3	-1.5	1.4	-1.3	-0.1	-1.3	-0.5	0.4	-1.3
Patch foraging water rate 18 sec	0.6	0.9	1.8	-0.1	-1.2	1.2	-1.3	-0.3	-0.9	-0.9	0.6	-0.9
Patch foraging water rate 24 sec	0.8	1.1	1.9	-0.5	-1.3	1.4	-1.3	0.0	-1.3	-0.7	0.2	-1.3
Patch foraging water rate 6 sec	0.8	1.1	2.3	-0.5	-1.4	1.5	-1.4	0.0	-1.3	-0.7	0.1	-1.3
Seeking ratio, delayed vs. immediate footshock	0.3	0.3	0.5	0.2	0.5	-0.5	0.1	-0.5	0.7	0.7	0.7	0.7
Distance traveled before self-admin	1.3	1.4	2.5	1.2	1.5	-1.3	1.3	0.6	1.1	1.6	-0.5	1.1
Distance traveled after self-admin	0.2	0.2	0.5	0.7	0.6	-0.5	0.3	0.1	0.4	0.3	-0.1	0.4
Extensor digitorum longus weight	4.5	17.7	24.3	3.7	4.9	-4.8	4.9	1.7	4.9	4.7	-0.6	4.9
Bone: elastic displacement	1.0	1.1	2.1	-0.7	-0.7	1.0	-0.6	0.9	-1.5	-1.1	-1.2	-1.5
Bone: elastic work	0.5	0.7	2.2	0.5	0.7	-0.2	0.7	1.4	-0.1	0.8	-1.5	-0.1
Bone: endosteal estimation	1.2	2.6	9.7	-1.3	-1.4	0.6	-1.4	-2.7	0.1	-0.6	3.1	0.1
Bone: endosteal perimeter	1.7	3.6	12.3	-1.4	-1.7	0.7	-1.7	-3.3	-0.0	-1.0	3.5	0.0
Epididymis fat weight	0.6	1.5	5.4	-0.5	-0.9	0.4	-1.1	-2.2	0.4	-0.4	2.3	0.5
Delta time in closed arm before/after self-admin	2.2	2.2	4.6	0.9	1.7	-1.3	1.5	1.4	1.5	2.2	-0.8	1.5
Delta time in open arm before/after self-admin	1.7	1.7	6.1	2.5	1.3	-1.3	1.5	0.8	1.0	0.5	-0.6	1.0
Diff in mean of infusions in LGA sessions	1.6	1.8	3.3	1.4	1.5	-1.0	1.4	1.7	0.7	1.3	-1.8	0.7
Delay discount exponential model param	0.6	0.6	1.7	1.3	0.3	-0.2	0.4	1.3	-0.5	0.5	-1.0	-0.5
Extinction: sum of active levers before priming	1.8	1.8	3.3	1.4	1.4	-1.3	1.8	0.9	1.4	1.4	-0.7	1.4
Active lever presses in extinction session 6	1.5	1.5	3.5	1.9	1.1	-0.9	1.4	1.2	0.7	1.1	-1.4	0.6
Bone: final force	0.9	1.5	3.5	1.9	1.3	-1.4	1.3	0.3	1.3	1.1	-0.0	1.2
Bone: final moment	0.8	1.4	3.4	1.8	1.2	-1.3	1.2	0.2	1.2	1.0	-0.0	1.2
Food consumed during 24 hour testing period	0.4	0.5	1.0	0.3	-0.7	0.7	-0.7	0.0	-1.0	-0.7	-0.3	-1.0
Glucose	2.4	3.7	10.6	-3.3	-1.9	1.4	-1.9	-2.3	-1.1	-1.4	1.9	-1.1
Heart weight	0.7	1.0	4.4	-2.1	-0.6	0.6	-1.1	-0.9	-0.1	-0.8	1.1	-0.1
Delay discount hyperbolic model param	0.6	0.7	1.9	1.4	0.3	-0.1	0.4	1.4	-0.5	0.4	-1.1	-0.6
Intermittent access intake day 1-15 change	1.1	1.1	2.3	0.3	-1.0	1.1	-1.0	0.1	-1.5	-1.1	-0.6	-1.5
Intermittent access intake escalation	0.6	0.6	1.3	0.7	-0.6	0.7	-0.6	0.3	-1.1	-0.9	-0.5	-1.1
Intermittent access intake escalation 2	0.4	0.4	2.1	1.5	-0.0	0.1	-0.0	0.5	-0.4	-0.2	-0.8	-0.5
Intermitt. access day 1 inactive lever presses	0.8	0.8	3.5	-0.5	-0.6	0.0	-0.6	-1.6	0.1	-0.6	1.9	0.1
Intermitt. access day 15 inactive lever presses	1.6	1.7	4.3	1.5	0.4	-1.2	0.4	-1.7	1.4	0.6	2.1	1.4
Intermitt. access escalation Index	0.8	0.7	1.9	-0.7	-0.7	0.4	-0.7	-1.4	0.1	-1.1	1.3	0.1
Intermittent access day 1 total infusions	1.8	2.1	8.8	-0.7	-0.2	-0.7	-0.2	-2.5	1.1	-0.1	3.0	1.1
Intermittent access day 15 total infusions	1.5	1.7	4.0	-0.4	-1.4	0.7	-1.4	-2.0	-0.8	-1.5	1.9	-0.8
Intermittent access terminal intake (last 3 days)	0.6	0.7	2.6	0.8	-0.2	-0.5	-0.2	-1.5	0.4	-0.3	1.6	0.4
Intermittent access total infusions	0.9	1.0	4.1	0.1	-0.4	-0.3	-0.4	-1.9	0.4	-0.6	2.0	0.4
Intermittent access day 1 locomotion	1.8	1.9	7.1	-0.2	0.2	-1.1	0.2	-2.0	1.5	0.2	2.7	1.5
Intermittent access day 15 total locomotion	1.1	1.2	3.0	1.1	0.6	-1.3	0.6	-1.2	1.2	0.3	1.7	1.2
Intermittent access total locomotion	2.5	2.9	9.7	0.9	0.5	-1.6	0.5	-2.5	1.8	0.3	3.1	1.8
Intermittent access standard deviation	0.7	0.7	1.5	1.0	-0.1	0.4	-0.1	1.2	-1.1	0.0	-1.1	-1.2
Left kidney weight	0.3	0.9	3.0	-0.4	-0.2	-0.1	-0.4	-1.5	1.1	0.1	1.7	1.1
Right kidney weight	0.2	0.7	1.7	-0.1	0.2	-0.5	0.1	-1.1	1.1	0.3	1.3	1.1
Cocaine induced anxiety	0.5	0.6	1.7	1.3	0.8	-0.8	0.8	0.7	0.5	0.7	-0.4	0.5
Post-drug Anxiety	0.8	0.9	1.4	1.2	1.1	-1.1	1.1	0.8	0.7	1.2	-0.5	0.6
Baseline Anxiety	0.6	0.6	1.1	0.4	0.9	-0.8	1.0	0.7	0.7	1.0	-0.5	0.7
Tail length	0.5	1.5	4.5	1.4	1.0	-0.3	0.7	2.1	0.5	1.6	-1.6	0.5
Length with tail	1.1	3.9	9.1	2.0	2.0	-1.7	1.6	0.9	2.4	3.0	-0.3	2.5
Length without tail	1.0	2.1	4.2	1.1	1.3	-1.4	1.1	-0.5	2.1	2.0	0.6	2.1
Times rat made contact with spout	0.4	0.5	2.0	0.6	0.5	-0.1	0.3	1.4	-0.3	0.4	-1.2	-0.3
Lifetime Intake	0.6	0.7	3.4	-0.1	-0.3	-0.4	-0.3	-1.5	0.4	-0.5	1.8	0.4
Liver weight, left	0.9	1.5	3.5	-1.9	-1.3	1.4	-1.5	-0.7	-1.1	-1.0	0.1	-1.1
Liver weight, right	0.1	0.1	0.5	-0.6	-0.2	0.0	-0.3	-0.7	-0.2	0.2	0.4	-0.2
Locomotor activity	0.7	1.1	2.3	-0.6	-1.3	1.5	-1.4	-0.1	-1.3	-0.2	-0.5	-1.3
Locomotor testing distance	0.5	0.8	1.4	-0.7	-1.1	1.2	-1.2	-0.3	-1.2	-0.3	-0.2	-1.2
Locomotor testing rearing	0.4	0.7	1.8	-0.2	-0.8	0.9	-0.9	0.1	-1.3	-0.2	-0.3	-1.4
Locomotion in novel chamber	1.4	1.8	4.0	-1.4	-1.6	1.0	-1.4	-2.0	-0.9	-0.8	1.6	-0.9
Locomotion in novel chamber post-restriction	1.0	1.2	2.1	-1.2	-1.1	1.3	-1.1	0.1	-1.5	-1.0	-0.3	-1.4
Fecal boli incidents, locomotor time 1	0.3	0.3	1.1	0.5	0.9	-0.8	0.2	0.1	0.2	1.0	-0.1	0.1
Change in fecal boli incidents, locomotor task	2.0	1.8	5.1	-2.3	-1.6	1.3	-1.3	-1.0	-0.8	-1.3	1.2	-0.7
Time >=10cm from walls, locomotor time 1	0.7	0.7	2.6	-0.0	-0.5	0.0	-0.7	-1.5	-0.0	-0.8	1.6	-0.1
Bouts of movement, locomotor time 1	2.5	2.8	5.9	2.0	1.8	-0.9	1.0	2.3	0.3	2.0	-2.4	0.2
Total resting periods, locomotor time 1	1.7	1.8	3.6	1.8	1.6	-0.8	0.8	1.7	0.4	1.7	-1.9	0.3
Rest time, locomotor task time 1	0.3	0.3	1.4	-1.2	-0.2	0.5	-0.9	-0.5	-0.4	-0.1	0.1	-0.4
Distance moved, locomotor task time 1	0.1	0.1	0.5	0.3	-0.3	-0.1	0.6	0.0	0.1	-0.7	0.4	0.1
Vertical activity count, locomotor time 1	1.8	1.8	5.0	-0.6	-2.0	1.6	-0.8	-0.3	-1.4	-2.2	0.4	-1.4
Time >=10cm from walls, locomotor time 2	0.2	0.2	0.4	0.3	-0.4	0.4	-0.5	-0.1	-0.6	-0.6	-0.1	-0.6
Bouts of movement, locomotor time 2	5.5	5.9	9.6	3.1	3.1	-2.7	2.7	2.3	1.7	2.6	-1.5	1.7
Total resting periods, locomotor time 2	5.0	5.3	9.1	2.9	3.0	-2.6	2.5	2.1	1.7	2.4	-1.3	1.6
Rest time, locomotor task time 2	0.3	0.4	1.6	-1.3	-0.4	0.5	-0.7	-0.5	-0.5	-0.0	0.5	-0.6
Distance moved, locomotor task time 2	0.3	0.3	1.2	0.1	-0.4	0.5	0.0	0.5	-0.6	-1.1	-0.7	-0.5
Vertical activity count, locomotor time 2	2.1	2.2	3.7	-0.9	-1.8	1.9	-0.7	0.9	-1.8	-1.9	-1.2	-1.7
Light reinforcement 1	0.2	0.3	0.7	0.0	-0.5	0.4	-0.6	-0.3	-0.8	-0.7	-0.3	-0.8
Light reinforcement 2	0.6	0.8	3.0	0.3	-0.6	0.3	-1.1	-1.7	0.1	-0.8	1.5	0.1
Bone: marrow area	1.3	2.8	9.9	-1.4	-1.6	0.7	-1.6	-2.8	-0.0	-0.7	3.1	0.0
Bone: maximum diameter	0.3	0.5	1.4	1.0	0.0	-0.4	0.0	-1.0	0.7	0.5	1.2	0.7
Bone: maximum force	1.5	2.6	4.4	2.0	1.4	-1.8	1.4	-0.8	2.1	1.3	1.1	2.1
Bone: maximum moment	1.4	2.4	4.0	1.9	1.3	-1.8	1.3	-0.7	2.0	1.3	1.0	2.0
Mean time between licks in bursts	0.6	0.9	1.7	0.6	1.3	-1.1	1.3	1.3	0.7	-0.2	-0.8	0.7
Mean num. licks in bursts	0.5	0.6	1.8	0.3	0.0	0.2	0.0	1.3	-0.9	-0.5	-1.3	-0.9
Cd content in liver	1.3	1.5	3.9	-2.0	-1.1	1.0	-1.0	-0.6	-1.5	-1.1	0.0	-1.5
Co content in liver	2.2	2.6	5.3	-0.7	-1.4	1.8	-1.3	1.1	-2.3	-1.6	-1.3	-2.3
Cu content in liver	0.1	0.1	0.7	0.2	0.2	0.1	0.2	0.8	0.1	0.5	-0.4	0.1
Fe content in liver	0.1	0.1	0.4	0.4	0.3	-0.3	0.4	0.2	0.3	0.6	0.1	0.3
K content in liver	1.1	1.0	1.9	1.1	0.5	-1.0	0.6	-1.2	1.4	0.2	1.1	1.4
Mg content in liver	0.8	0.8	1.6	0.7	0.5	-1.0	0.4	-1.3	1.0	0.5	1.2	1.0
Mn content in liver	0.8	0.9	2.0	1.0	0.9	-1.0	1.0	-0.3	1.4	0.1	0.1	1.4
Na content in liver	0.2	0.2	0.5	0.5	0.5	-0.7	0.5	0.0	0.3	-0.3	-0.2	0.3
Rb content in liver	0.7	0.9	1.4	-0.6	-1.2	0.9	-1.2	-1.0	-0.9	-0.4	1.0	-0.9
Se content in liver	0.6	0.8	1.7	0.9	0.8	-1.0	0.8	-0.2	1.3	0.5	0.6	1.3
Sr content in liver	5.2	4.8	7.3	1.6	2.7	-2.3	2.7	2.1	1.9	2.4	-1.5	1.9
Zn content in liver	4.3	4.7	12.2	3.5	2.5	-2.5	2.4	1.0	1.9	1.6	-0.9	1.9
Bone: minimum diameter	1.1	2.0	7.5	0.5	-1.1	0.2	-1.1	-2.7	0.3	-0.6	2.7	0.3
Time in familiar zone, hab. session 1	0.4	0.3	1.5	1.2	0.2	-0.4	0.3	-0.0	0.3	1.0	0.2	0.3
Time in novel zone, hab. session 1	1.4	1.3	2.6	-1.6	-1.1	1.2	-1.0	-0.0	-1.3	-1.5	-0.1	-1.3
Total zone transitions, hab. session 1	0.2	0.2	0.8	0.2	0.5	-0.3	0.6	0.6	0.2	0.5	-0.9	0.2
Total locomotion distance, hab. session 1	0.3	0.4	0.7	0.6	0.5	-0.8	0.5	-0.6	0.7	0.6	0.6	0.7
Locomotion velocity, hab. session 1	0.5	0.8	1.2	1.0	1.0	-1.1	1.0	-0.1	1.0	1.0	0.1	1.0
Time in familiar zone, hab. session 2	1.0	1.0	1.9	-1.2	-0.9	1.1	-0.9	0.2	-1.4	-0.6	-0.5	-1.4
Time in novel zone, hab. session 2	0.8	0.8	1.9	1.4	0.9	-1.0	0.9	0.0	1.1	0.4	0.3	1.1
Total zone transitions, hab. session 2	0.6	0.8	2.1	1.4	1.0	-1.0	1.0	0.5	0.7	0.7	-0.6	0.6
Total locomotion distance, hab. session 2	0.4	0.6	1.5	1.2	0.8	-1.0	0.8	0.1	0.6	0.7	0.2	0.6
Locomotion velocity, hab. session 2	0.3	0.4	1.1	1.0	0.6	-0.9	0.6	-0.3	0.6	0.6	0.5	0.6
Novel to familiar place preference ratio	1.0	1.0	2.3	0.9	1.0	-0.9	1.0	0.2	1.5	0.9	0.1	1.5
Novelty place preference	0.7	0.7	1.8	0.7	0.8	-0.7	0.7	0.1	1.3	0.7	0.2	1.3
Time in novel zone, NPP test	1.0	1.0	2.2	0.8	1.1	-1.0	1.0	0.3	1.5	1.1	0.1	1.5
Total zone transitions, NPP test	0.7	1.0	1.6	1.1	1.2	-1.0	1.3	1.1	0.7	0.7	-1.2	0.7
Total locomotion distance, NPP test	0.1	0.1	0.5	0.7	0.4	-0.4	0.4	0.2	0.3	0.2	-0.2	0.3
Locomotion velocity, NPP test	0.0	0.1	0.2	0.5	-0.0	0.1	-0.0	0.0	-0.1	-0.4	-0.3	-0.1
Intraocular pressure	0.2	0.2	1.0	-0.1	0.3	-0.0	0.1	1.0	-0.3	-0.2	-0.8	-0.3
Delta distance traveled before/after self-admin	0.5	0.6	1.2	-1.0	-0.7	0.8	-0.8	-0.1	-0.8	-1.1	0.2	-0.8
Delta ambulatory time before/after self-admin	0.8	0.9	1.6	-1.1	-0.8	1.0	-1.0	0.1	-1.1	-1.3	-0.1	-1.1
Parametrial fat weight	1.5	2.9	9.1	-1.6	-1.5	0.8	-1.7	-2.8	0.2	-0.8	3.0	0.2
Pavlov. Cond. lever latency	0.4	0.5	1.5	-1.2	-0.5	0.8	-0.5	0.7	-0.8	0.3	-0.4	-0.7
Pavlov. Cond. magazine entry latency	0.7	0.9	1.8	1.1	1.0	-1.3	1.0	-0.5	1.2	0.3	0.5	1.2
Pavlov. Cond. change in total contacts	0.3	0.4	1.7	1.3	0.4	-0.7	0.5	-0.4	0.4	-0.5	0.2	0.4
Pavlov. Cond. index score	0.2	0.3	1.0	1.0	0.5	-0.6	0.5	-0.3	0.4	-0.0	0.0	0.4
Pavlov. Cond. latency score	0.1	0.2	0.5	0.7	0.2	-0.5	0.2	-0.6	0.3	-0.3	0.2	0.2
Pavlov. Cond. lever contacts	0.2	0.2	0.7	0.5	-0.1	-0.1	-0.1	-0.8	0.1	-0.8	0.4	0.1
Pavlov. Cond. magazine entry number	0.3	0.4	0.8	-0.9	-0.8	0.8	-0.8	-0.2	-0.5	-0.2	0.4	-0.5
Pavlov. Cond. intertrial magazine entries	0.3	0.3	1.0	1.0	-0.1	0.3	-0.1	0.3	-0.4	0.6	-1.0	-0.5
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	1.7	1.3	0.7	-0.8	0.7	-0.1	0.6	-0.0	-0.1	0.5
Pavlov. Cond. response bias	0.5	0.6	2.4	1.5	0.8	-1.0	0.8	-0.2	0.7	-0.2	0.0	0.7
Pavlov. Cond. lever latency	1.6	2.2	6.7	-2.6	-1.3	1.8	-1.3	0.0	-1.5	-1.0	-0.8	-1.5
Pavlov. Cond. magazine entry latency	6.3	7.3	18.7	4.3	3.0	-3.0	3.1	1.9	2.3	2.4	-0.8	2.2
Pavlov. Cond. change in total contacts	2.6	3.6	12.0	3.5	1.9	-2.3	1.9	0.7	1.5	1.7	-0.0	1.5
Pavlov. Cond. index score	4.9	6.3	16.6	4.1	2.6	-2.9	2.6	1.0	2.3	2.5	0.1	2.3
Pavlov. Cond. latency score	4.7	5.9	15.1	3.9	2.5	-2.8	2.5	0.7	2.3	2.5	0.3	2.3
Pavlov. Cond. lever contacts	1.8	2.4	7.9	2.8	1.6	-1.8	1.6	0.9	1.1	1.5	-0.2	1.1
Pavlov. Cond. magazine entry number	9.4	11.4	24.1	-4.9	-3.7	3.8	-3.8	-2.1	-3.1	-3.5	0.8	-3.0
Pavlov. Cond. intertrial magazine entries	2.2	2.9	8.6	-2.9	-1.8	1.8	-1.8	-1.1	-1.7	-1.1	0.1	-1.7
Pavlov. Cond. lever-magazine prob. diff.	5.3	6.7	17.6	4.2	2.7	-3.0	2.8	1.1	2.4	2.6	-0.1	2.3
Pavlov. Cond. response bias	3.3	4.4	12.9	3.6	2.3	-2.5	2.3	1.2	1.8	1.7	-0.3	1.7
Time in closed arm before self-admin	0.1	0.2	0.9	-0.2	-0.2	-0.0	-0.3	-0.9	0.0	-0.3	0.6	0.0
Time in closed arm after self-admin	0.2	0.2	0.5	-0.7	-0.3	0.4	-0.5	-0.3	-0.2	0.5	0.2	-0.2
Time in open arm before self-admin	1.5	1.7	3.1	-1.4	-1.5	1.8	-1.2	0.5	-1.6	-1.0	-0.4	-1.5
Time in open arm after self-admin	0.5	0.6	1.7	0.5	-0.3	0.6	0.0	1.2	-0.8	-0.5	-1.3	-0.7
Bone: periosteal estimation	0.5	1.1	4.4	0.5	-0.6	-0.1	-0.5	-1.9	0.6	0.2	2.1	0.6
Bone: periosteal perimeter	0.3	0.4	1.7	0.4	-0.3	-0.2	-0.3	-1.3	0.2	0.4	1.2	0.2
Bone: post-yield work	1.9	2.6	10.3	-0.1	-0.8	-0.2	-0.8	-3.2	0.9	-0.5	3.1	1.0
Progressive ratio test 1 active lever presses	0.8	0.9	1.7	-0.6	-1.0	0.8	-1.1	-1.0	-0.8	-1.3	0.8	-0.8
Progressive ratio test 1 breakpoint	0.9	1.0	1.8	-0.8	-1.1	0.9	-1.1	-0.8	-1.0	-1.3	0.6	-1.0
Progressive ratio test 1 inactive lever presses	0.9	0.9	1.7	1.0	0.8	-1.1	0.8	-0.4	1.3	0.8	0.9	1.3
Progressive ratio test 2 active lever presses	0.8	0.8	2.2	-0.4	-0.9	0.4	-0.9	-1.5	-0.4	-1.1	1.4	-0.4
Progressive ratio test 2 breakpoint	1.2	1.4	2.5	-0.6	-1.3	0.9	-1.3	-1.6	-0.9	-1.4	1.4	-0.9
Progressive ratio test 2 inactive lever presses	0.7	0.8	3.4	0.9	-0.2	-0.5	-0.1	-1.6	0.6	-0.1	1.9	0.5
Incentive Sensitization - Responses	0.3	0.3	0.7	0.6	0.1	-0.5	0.1	-0.9	0.5	-0.2	0.8	0.5
Incentive Sensitization - Breakpoint	0.4	0.4	1.3	0.4	0.0	-0.5	0.0	-1.2	0.6	-0.3	1.1	0.6
Sum of active levers in priming session hrs 5-6	0.7	0.7	2.2	1.5	0.8	-0.5	0.9	1.0	0.2	0.3	-1.2	0.2
Progressive ratio	0.2	0.2	0.5	0.1	0.2	-0.4	0.2	-0.6	0.5	-0.7	0.7	0.5
Food seeking constrained by brief footshock	0.2	0.3	1.2	-0.1	-0.2	0.3	-0.4	0.5	-0.5	-1.1	-0.2	-0.5
Seeking ratio, punishment vs. effort	0.2	0.2	0.7	-0.1	-0.2	0.4	-0.3	0.8	-0.5	0.1	-0.6	-0.5
Retroperitoneal fat weight	2.4	8.0	16.3	-3.5	-3.1	2.4	-3.3	-4.0	-0.9	-2.0	3.6	-0.8
Reaction time number correct	0.5	0.7	3.9	-0.6	0.5	-0.1	0.0	1.0	-0.2	2.0	-1.0	-0.2
Reaction time mean minus median	0.4	0.5	1.1	0.4	0.9	-0.7	1.0	0.8	0.2	0.5	-1.0	0.2
Reaction time mean minus median AUC	0.6	0.8	3.1	0.1	0.7	-0.3	0.7	1.5	-0.5	0.7	-1.8	-0.5
Reaction time num false alarms	0.5	0.6	1.2	-0.4	-0.9	1.1	-0.8	0.7	-0.9	-0.6	-0.7	-0.9
Reaction time num false alarms AUC	0.5	0.7	1.4	-0.5	-0.6	1.0	-0.6	1.2	-0.8	-0.5	-1.2	-0.7
Reaction time trials correct on left	0.5	0.7	3.9	-0.6	0.5	-0.1	0.0	1.0	-0.2	2.0	-1.0	-0.2
Reaction time trials on left	0.6	0.8	4.0	-0.7	0.5	-0.0	0.1	1.1	-0.2	2.0	-1.1	-0.3
Reaction time mean	0.2	0.3	0.6	0.3	0.5	-0.5	0.8	0.7	-0.3	-0.0	-0.7	-0.3
Reaction time mean AUC	0.1	0.2	0.4	0.3	0.3	-0.4	0.6	0.5	-0.4	-0.2	-0.5	-0.5
Median of all reaction times	0.2	0.2	0.5	0.4	0.6	-0.7	0.7	0.4	0.1	0.2	-0.3	0.1
Reaction time omissions	0.4	0.6	1.9	-0.7	-0.0	0.5	0.0	1.4	-0.6	0.3	-1.3	-0.6
Reaction time false alarm rate	0.4	0.5	2.2	-0.0	-0.9	0.9	-0.6	0.2	-0.5	-1.5	-0.2	-0.4
Reaction time premature initiation rate	1.6	2.1	4.6	1.4	1.5	-1.6	1.4	-0.2	2.1	0.9	0.7	2.1
Reaction time premature initiations	1.6	2.3	4.3	1.2	1.8	-1.5	1.5	0.8	1.8	2.1	-0.3	1.8
Std. dev. reaction times	0.4	0.6	2.0	0.0	0.2	0.1	0.3	1.2	-0.8	-0.0	-1.4	-0.8
Reaction time trials completed	0.6	0.8	4.0	-0.7	0.5	-0.0	0.1	1.1	-0.2	2.0	-1.1	-0.3
Reaction time trials AUC	0.5	0.7	3.9	-0.8	0.5	-0.0	-0.0	0.9	-0.3	2.0	-0.9	-0.3
Run reversals in cocaine runway, females	0.6	0.5	1.2	-0.3	0.4	-0.6	0.4	-0.7	1.1	0.4	1.1	1.1
Run reversals in cocaine runway, males	2.3	2.2	5.4	-1.3	-1.7	1.7	-1.7	-0.8	-1.2	-2.3	0.1	-1.2
Latency to leave start box in cocaine runway	1.3	1.4	5.1	-1.3	-0.8	0.4	-1.0	-2.3	0.2	-0.7	2.0	0.3
Latency to leave start box in cocaine runway, F	0.3	0.4	1.3	-0.0	0.2	-0.3	-0.1	-1.1	0.7	0.1	1.0	0.7
Latency to leave start box in cocaine runway, M	3.6	3.5	6.3	-2.5	-2.1	1.8	-2.2	-1.9	-1.4	-1.9	1.3	-1.4
Std. dev. time between licks in bursts	0.3	0.3	1.2	-0.1	-0.6	0.5	-0.6	-0.2	-0.5	-1.1	0.2	-0.5
Total sessions with >9 infusions	0.8	0.9	2.9	-1.4	-0.5	0.0	-0.5	-1.4	0.1	-0.8	1.7	0.2
Short access day 1 total inactive lever presses	0.7	0.8	2.2	-1.2	-0.7	0.3	-0.7	-1.4	-0.0	-0.7	1.5	-0.0
Short access day 10 total inactive lever presses	1.2	1.3	2.9	-1.5	-1.2	1.1	-1.2	-0.6	-1.0	-1.7	0.7	-1.0
Short access day 1 total infusions	0.3	0.3	1.0	-1.0	-0.3	0.1	-0.3	-0.7	-0.1	-0.5	0.9	-0.1
Short access day 10 total infusions	1.6	1.7	6.8	-0.4	0.2	-1.0	0.2	-2.1	1.3	0.0	2.6	1.3
Short access total infusions	0.5	0.6	2.5	-0.5	0.1	-0.6	0.1	-1.1	0.6	0.0	1.6	0.6
Short access day 1 locomotion	0.7	0.8	1.5	0.6	0.7	-1.0	0.7	-0.5	1.2	0.5	1.0	1.2
Short access day 10 total locomotion	1.4	1.6	3.9	0.8	0.7	-1.4	0.7	-1.2	1.6	0.6	2.0	1.5
Short access total locomotion	2.1	2.1	3.8	0.9	1.1	-1.7	1.1	-1.1	2.0	0.9	1.9	2.0
One hour access (0.3 mA shock)	1.4	1.7	3.5	-0.5	-1.4	0.9	-1.5	-1.9	-0.8	-1.4	1.8	-0.8
Compulsive drug intake	1.1	1.2	4.6	0.4	0.7	-0.0	0.7	2.1	-0.2	0.9	-2.0	-0.2
One hour access (shock baseline)	2.4	2.8	5.3	-0.6	-1.9	1.3	-1.9	-2.3	-1.2	-2.0	1.9	-1.2
Social response proportion	0.3	0.4	0.8	-0.4	-0.9	0.9	-0.9	-0.2	-0.5	-0.5	0.2	-0.5
Social responses	0.6	0.8	1.6	0.2	-1.0	1.2	-0.8	0.8	-1.1	-0.5	-1.0	-1.1
Social time	0.7	0.9	2.8	-0.2	-0.2	0.7	-0.2	1.5	-1.1	-0.2	-1.7	-1.1
Soleus weight	1.5	4.5	7.0	-1.0	-2.6	2.3	-2.7	-1.6	-2.4	-2.3	0.9	-2.4
Bone: stiffness	0.4	0.7	2.7	1.6	0.4	-0.7	0.4	-0.5	0.9	0.6	0.7	0.9
Tibialis anterior weight	5.9	20.2	31.0	3.2	5.6	-5.0	5.6	2.8	4.7	5.3	-2.4	4.6
Time to tail flick, vehicle, before self-admin	1.1	1.1	2.2	-0.1	0.8	-1.2	0.8	-1.0	1.5	0.7	1.2	1.5
Time to tail flick, vehicle, after self-admin	0.8	0.8	1.9	-0.5	1.1	-1.1	0.8	0.0	1.1	1.4	0.3	1.1
Time to tail flick, test, before self-admin	0.6	0.6	1.3	-1.0	0.1	-0.3	0.1	-1.0	0.9	0.4	1.2	0.9
Time to tail flick, test, after self-admin	0.4	0.4	0.7	-0.4	-0.6	0.7	-0.6	0.1	-0.7	-0.8	-0.3	-0.7
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.3	-0.1	0.2	0.0	-0.0	0.6	-0.2	0.5	-0.5	-0.2
Delta time to tail flick, test, before/after SA	1.2	1.1	3.0	1.7	0.1	0.2	0.1	1.5	-0.8	-0.5	-1.6	-0.8
Tibia length	0.9	2.5	4.8	1.7	1.5	-1.6	1.5	-0.3	1.9	2.2	0.3	1.9
Ambulatory time before self-admin	1.2	1.2	3.0	1.7	1.2	-1.1	1.2	0.6	0.9	1.2	-0.6	0.8
Ambulatory time after self-admin	0.4	0.4	0.6	0.8	0.6	-0.7	0.2	-0.8	0.7	0.2	0.8	0.6
Bone: tissue strength	0.5	0.5	1.6	-0.2	-0.7	0.6	-0.7	-0.5	-0.7	-1.3	0.3	-0.7
Total heroin consumption	2.5	2.9	5.8	1.5	1.8	-1.1	2.0	2.4	0.8	1.6	-2.4	0.8
Bone: trabecular number	0.5	0.7	1.5	0.8	0.6	-0.9	0.6	-0.7	1.2	0.3	0.9	1.2
Bone: trabecular spacing	0.6	0.7	1.9	0.2	-0.1	0.4	-0.1	1.3	-1.2	-0.1	-1.4	-1.2
Bone: trabecular thickness	0.4	0.5	1.4	0.3	-0.9	0.6	-0.9	-1.2	-0.3	0.2	0.9	-0.3
Bone: trabecular tissue density	2.2	3.1	4.7	-1.6	-2.1	2.2	-2.1	-0.8	-2.1	-1.4	0.3	-2.1
Water consumed over 24 hours	0.4	0.4	2.4	1.5	0.1	0.1	0.1	0.9	0.0	0.7	-0.5	0.1
Number of responses in last shaping day	0.1	0.1	0.5	0.4	0.2	-0.1	0.2	0.7	0.0	0.2	-0.5	0.0