Rab27a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Rab27a	0.11	0.06	2.4e-10	0.07	0.06	0.08	0.08	1.3e-08	1.4e-07	2.9e-09	4.3e-09
2	pVTA	gene expression	Rab27a	0.04	0.03	3.3e-03	0.02	0.01	0.01	0.01	1.1e-02	6.6e-02	6.8e-02	6.3e-02
3	PL	gene expression	Rab27a	0.24	0.07	0.0e+00	0.31	0.29	0.31	0.32	3.4e-34	1.9e-32	3.4e-34	3.5e-35
4	BLA	gene expression	Rab27a	0.4	0.1	0.0e+00	0.4	0.4	0.42	0.42	8.6e-23	1.9e-22	6.6e-24	5.7e-24
5	Brain	gene expression	Rab27a	0.15	0.07	4.3e-13	0.17	0.15	0.16	0.16	2.1e-15	5.5e-14	6.4e-15	4.9e-15
6	OFC	gene expression	Rab27a	0.37	0.14	1.8e-04	0.15	0.07	0.08	0.11	2.5e-04	8.0e-03	7.0e-03	1.4e-03
7	IC	gene expression	Rab27a	0.2	0.09	4.4e-09	0.22	0.22	0.22	0.21	8.7e-10	2.1e-09	1.3e-09	2.1e-09
8	IL	gene expression	Rab27a	0.32	0.14	1.1e-04	0.2	0.1	0.18	0.19	1.8e-05	1.8e-03	4.0e-05	3.0e-05
9	NAcc	gene expression	Rab27a	0.09	0.04	3.2e-13	0.1	0.09	0.09	0.1	8.3e-15	8.9e-13	1.3e-13	5.2e-15

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9
Bone: apparent density	0.1	0.1	0.5	0.4	0.7	-0.4	-0.3	0.3	0.4	0.2	0.2	-0.2
Area under the delay curve	0.0	0.1	0.1	0.4	0.2	0.1	0.2	-0.1	-0.1	-0.4	-0.4	-0.1
BMI with tail	8.3	28.8	31.8	-4.4	-4.8	5.6	5.5	-5.6	-5.6	-5.6	-5.6	5.5
BMI without tail	1.9	10.2	12.6	-2.1	-2.4	3.4	3.3	-3.3	-3.3	-3.5	-3.6	3.5
Body weight	3.7	16.2	17.4	-3.5	-4.0	4.1	4.1	-4.2	-4.1	-4.1	-4.2	4.1
Weight adjusted by age	2.1	6.2	8.0	-2.5	-2.8	2.4	2.4	-2.3	-2.5	-2.4	-2.5	2.7
Bone surface	0.2	0.3	0.6	-0.6	-0.3	0.5	0.5	-0.5	-0.4	-0.7	-0.8	0.7
Bone volume	0.2	0.4	0.6	-0.6	-0.4	0.5	0.6	-0.6	-0.4	-0.7	-0.8	0.7
Breakpoint value in progressive ratio session	0.1	0.1	0.3	0.0	0.4	0.4	0.5	-0.3	-0.5	-0.5	-0.2	0.2
Number of licking bursts	0.8	2.5	3.0	1.7	1.5	-1.7	-1.6	1.7	1.7	1.5	1.4	-1.5
Context. condit. distance diff. score	0.1	0.1	0.2	0.3	-0.2	-0.4	-0.4	0.4	0.3	0.5	0.4	-0.4
Locomotion velocity, session 1	1.3	1.5	2.0	-1.4	-0.6	1.3	1.3	-1.2	-1.4	-1.2	-1.2	1.1
Locomotion distance, session 1	0.1	0.1	0.6	0.4	0.8	-0.2	-0.2	0.2	0.2	0.2	0.2	-0.3
Locomotion velocity, session 2	0.2	0.2	0.3	0.1	0.6	0.5	0.5	-0.4	-0.4	-0.4	-0.4	0.4
Locomotion distance, session 2	0.6	0.8	1.2	-0.0	0.3	1.0	1.1	-1.0	-0.9	-1.0	-1.1	1.0
Locomotion velocity, session 3	0.1	0.2	0.3	-0.0	0.3	0.5	0.5	-0.5	-0.5	-0.2	-0.2	0.4
Locomotion distance, session 3	2.1	2.4	3.7	1.8	1.9	-1.4	-1.5	1.4	1.4	1.4	1.6	-1.4
Stereotopy head waving bouts, day 3	0.6	0.7	2.1	-1.2	-1.4	0.7	0.7	-0.7	-0.6	-0.4	-0.5	0.5
Stereotopy head waving duration, day 3	1.3	1.6	3.4	-1.8	-1.8	1.1	1.1	-1.1	-1.1	-0.8	-0.9	0.9
Locomotion velocity, session 7	0.6	0.7	1.2	1.0	0.7	-0.9	-0.9	0.9	1.1	0.8	0.6	-0.6
Locomotion distance, session 7	0.8	1.1	2.3	1.3	1.5	-1.0	-0.9	1.0	1.1	0.9	0.7	-0.8
Stereotopy head waving bouts, day 7	1.1	1.2	1.7	-1.0	-0.9	1.3	1.2	-1.3	-1.3	-1.0	-1.0	1.1
Stereotopy head waving duration, day 7	1.1	1.4	1.6	-1.2	-1.0	1.3	1.2	-1.2	-1.2	-1.1	-1.1	1.2
Locomotion velocity, session 8	0.6	0.7	1.1	-0.8	-0.3	0.9	1.0	-0.8	-0.9	-0.8	-0.9	0.9
Locomotion distance, session 8	0.1	0.2	0.9	0.8	0.9	-0.1	0.1	0.1	-0.0	0.1	-0.1	-0.0
Degree of sensitization distance	0.0	0.0	0.1	0.0	0.3	-0.1	-0.0	0.1	0.1	0.1	-0.1	-0.1
Degree of sensitization stereotypy	0.9	1.0	1.5	-0.8	-0.6	1.2	1.1	-1.2	-1.2	-0.9	-0.9	1.0
Conditioned locomotion	0.1	0.1	0.2	0.3	-0.4	0.2	0.2	-0.3	-0.3	-0.4	-0.2	0.2
Cocaine response after cond. corrected	3.3	4.9	7.3	-2.7	-2.6	2.1	2.1	-2.1	-2.1	-2.0	-2.0	2.0
Cocaine response after cond. not corrected	2.2	3.3	5.3	-2.3	-2.3	1.7	1.7	-1.7	-1.7	-1.6	-1.5	1.6
Cocaine response before conditioning	0.8	0.9	1.8	1.4	0.9	-0.9	-0.9	0.9	0.9	0.8	0.9	-0.8
Saline control response	0.0	0.1	0.4	-0.6	-0.3	0.2	0.1	-0.2	-0.2	0.0	0.1	-0.0
Bone: connectivity density	0.8	1.3	3.5	1.2	1.9	-1.0	-1.0	1.0	1.1	0.9	0.8	-0.9
Bone: cortical apparent density	0.8	1.3	1.6	1.2	0.9	-1.3	-1.2	1.1	1.2	1.1	1.1	-1.2
Bone: cortical area	0.2	0.3	1.5	-1.1	-1.2	-0.0	-0.1	-0.0	0.1	-0.0	0.1	-0.1
Bone: cortical porosity	1.4	1.5	2.4	0.9	0.9	-1.1	-1.3	1.0	1.1	1.5	1.6	-1.4
Bone: cortical porosity	1.7	1.8	2.5	1.2	1.0	-1.3	-1.4	1.2	1.3	1.5	1.6	-1.5
Bone: cortical thickness	1.1	1.8	2.5	0.4	0.4	-1.4	-1.5	1.4	1.5	1.4	1.6	-1.6
Bone: cortical thickness	0.4	0.5	0.9	0.0	-0.2	-0.8	-0.8	0.8	0.9	0.6	0.6	-0.8
Bone: cortical tissue density	0.8	1.3	1.5	1.2	1.0	-1.2	-1.2	1.1	1.2	1.1	1.0	-1.2
Condit. Reinf. active minus inactive responses	0.6	0.7	2.8	1.7	1.3	-0.5	-0.5	0.4	0.5	0.4	0.5	-0.5
Condit. Reinf. active-inactive response ratio	1.0	1.0	1.4	1.1	0.4	-1.2	-1.2	1.1	1.2	0.9	0.9	-1.0
Condit. Reinf. active responses	0.3	0.4	1.5	1.2	1.2	0.4	0.3	-0.5	-0.4	-0.3	-0.2	0.3
Condit. Reinf. inactive responses	0.9	1.1	1.7	0.2	0.9	1.3	1.3	-1.3	-1.3	-0.9	-0.9	1.0
Incentive salience index mean	0.3	0.4	2.4	1.5	1.1	-0.2	-0.3	0.1	0.2	0.2	0.3	-0.2
Condit. Reinf. lever presses	0.2	0.3	1.6	1.3	0.8	0.1	-0.0	-0.2	-0.2	0.1	0.2	-0.1
Condit. Reinf. active minus inactive responses	1.8	2.8	3.1	-1.6	-1.4	1.7	1.7	-1.8	-1.7	-1.7	-1.7	1.7
Condit. Reinf. active-inactive response ratio	0.9	1.5	2.5	-1.6	-1.5	1.1	1.1	-1.1	-1.1	-1.1	-1.2	1.1
Condit. Reinf. active responses	1.3	1.8	2.3	-0.9	-1.0	1.5	1.4	-1.5	-1.5	-1.5	-1.4	1.4
Condit. Reinf. inactive responses	0.1	0.2	1.0	1.0	0.9	-0.0	-0.1	0.0	0.0	0.1	0.2	-0.1
Condit. Reinf. lever presses	0.5	0.7	1.0	0.4	0.1	-0.9	-0.9	0.9	0.8	1.0	1.0	-0.9
Condit. Reinf. lever reinforcers received	0.9	1.3	1.6	-0.8	-0.9	1.2	1.2	-1.3	-1.3	-1.2	-1.1	1.1
Conditioned reinforcement - actives	0.0	0.2	0.7	-0.3	-0.9	0.1	0.3	-0.0	-0.1	-0.3	-0.6	0.5
Conditioned reinforcement - inactives	0.0	0.1	0.5	-0.6	-0.7	-0.0	0.1	0.1	0.0	-0.2	-0.4	0.0
Conditioned locomotion	0.2	0.3	0.6	0.5	-0.1	-0.7	-0.6	0.7	0.7	0.4	0.2	-0.3
Patch foraging indifference point 0 sec	0.1	0.2	0.4	-0.3	-0.4	0.5	0.6	-0.5	-0.4	-0.5	-0.7	0.5
Patch foraging indifference point AUC	0.3	0.8	3.4	1.7	1.9	-0.5	-0.4	0.5	0.4	0.4	0.3	-0.4
Delay disc. indifference point, 0s delay	0.9	1.0	3.0	1.6	1.7	-0.7	-0.6	0.7	0.7	0.4	0.5	-0.8
Delay disc. indifference point, 16s delay	0.1	0.2	0.4	0.6	0.2	-0.4	-0.4	0.4	0.5	0.3	0.2	-0.6
Delay disc. indifference point, 2s delay	0.1	0.1	0.1	0.3	0.2	-0.3	-0.2	0.3	0.1	0.1	0.2	-0.2
Delay disc. indifference point, 24s delay	0.1	0.1	0.3	0.4	0.6	-0.2	-0.3	0.2	0.2	0.2	0.2	-0.5
Delay disc. indifference point, 4s delay	0.4	0.4	1.0	1.0	0.7	-0.6	-0.4	0.6	0.5	0.4	0.4	-0.6
Delay disc. indifference point, 8s delay	0.4	0.6	1.0	-0.1	-0.1	0.8	1.0	-0.8	-0.9	-1.0	-1.0	0.6
Indifference point function ln k	0.6	1.8	5.7	-1.9	-2.4	1.1	0.9	-1.0	-0.9	-1.2	-1.0	1.1
Indifference point function log k	0.6	1.8	5.7	-1.9	-2.4	1.1	0.9	-1.0	-0.9	-1.2	-1.0	1.1
Patch foraging total patch changes 0 sec	0.1	0.3	0.4	-0.5	-0.4	0.6	0.7	-0.6	-0.5	-0.5	-0.6	0.6
Patch foraging total patch changes 12 sec	0.3	0.5	1.7	0.7	1.3	-0.4	-0.4	0.5	0.4	0.7	0.6	-0.6
Patch foraging total patch changes 18 sec	0.1	0.1	0.4	0.3	0.6	-0.3	-0.2	0.3	0.2	0.4	0.4	-0.4
Patch foraging total patch changes 24 sec	0.1	0.2	1.5	0.4	1.2	0.0	0.1	-0.0	-0.1	0.3	0.2	-0.2
Patch foraging total patch changes 6 sec	0.2	0.4	1.2	0.7	1.1	0.4	0.6	-0.4	-0.4	-0.5	-0.5	0.5
Patch foraging time to switch 0 sec	0.3	1.0	1.4	0.8	0.5	-1.2	-1.0	1.2	1.0	1.2	0.8	-1.0
Patch foraging water rate 0 sec	0.6	2.4	2.8	-1.7	-1.3	1.7	1.6	-1.7	-1.5	-1.6	-1.4	1.4
Patch foraging water rate 12 sec	1.2	4.8	7.8	-2.8	-1.4	2.5	2.2	-2.5	-2.3	-2.1	-1.7	1.9
Patch foraging water rate 18 sec	0.1	0.3	1.0	-1.0	-0.2	0.7	0.5	-0.6	-0.5	-0.3	-0.1	0.3
Patch foraging water rate 24 sec	0.1	0.1	0.4	-0.2	0.7	0.0	-0.3	0.2	0.3	0.6	0.4	-0.3
Patch foraging water rate 6 sec	0.3	0.4	1.0	-1.0	-0.3	0.8	0.6	-0.8	-0.5	-0.5	-0.4	0.4
Seeking ratio, delayed vs. immediate footshock	1.4	2.0	3.2	-1.0	-1.3	1.4	1.4	-1.4	-1.3	-1.3	-1.8	1.8
Distance traveled before self-admin	0.0	0.0	0.1	0.0	-0.1	-0.3	-0.1	0.3	0.3	0.1	-0.1	-0.1
Distance traveled after self-admin	1.2	2.1	3.8	-2.0	-1.9	1.1	1.5	-1.1	-1.4	-1.1	-1.5	1.3
Extensor digitorum longus weight	8.3	33.3	35.7	-5.4	-5.0	5.9	5.9	-5.9	-5.9	-6.0	-5.9	5.9
Bone: elastic displacement	0.0	0.0	0.1	-0.0	-0.2	0.3	0.2	-0.2	-0.1	-0.3	-0.2	0.3
Bone: elastic work	0.1	0.1	0.2	0.2	-0.3	-0.3	-0.3	0.3	0.5	0.1	0.1	-0.2
Bone: endosteal estimation	2.2	5.3	7.3	-2.3	-2.7	2.2	2.3	-2.2	-2.2	-2.2	-2.3	2.3
Bone: endosteal perimeter	2.9	7.2	8.0	-2.6	-2.8	2.7	2.7	-2.7	-2.7	-2.6	-2.6	2.7
Epididymis fat weight	0.0	0.1	0.4	0.3	0.6	0.2	0.3	-0.1	-0.3	-0.0	-0.1	0.2
Delta time in closed arm before/after self-admin	0.4	0.4	0.6	0.5	0.2	-0.6	-0.7	0.6	0.7	0.8	0.6	-0.7
Delta time in open arm before/after self-admin	0.3	0.3	0.7	-0.1	0.4	-0.5	-0.4	0.6	0.5	0.6	0.8	-0.7
Diff in mean of infusions in LGA sessions	0.9	1.5	2.3	-0.4	-1.1	1.2	1.4	-1.1	-1.3	-1.4	-1.5	1.3
Delay discount exponential model param	0.0	0.1	0.2	-0.3	-0.1	-0.1	-0.3	0.1	0.2	0.4	0.4	-0.0
Extinction: sum of active levers before priming	0.0	0.0	0.1	-0.1	0.3	0.0	-0.0	-0.1	0.0	-0.0	0.1	-0.1
Active lever presses in extinction session 6	0.8	0.9	1.4	-0.8	-0.7	0.9	1.1	-0.8	-0.9	-0.9	-1.2	1.0
Bone: final force	0.4	0.6	1.5	-1.1	-1.2	0.6	0.6	-0.7	-0.6	-0.6	-0.5	0.6
Bone: final moment	0.2	0.3	1.3	-1.0	-1.2	0.3	0.3	-0.4	-0.3	-0.3	-0.2	0.3
Food consumed during 24 hour testing period	0.4	0.9	2.8	-1.5	-1.7	0.6	0.6	-0.6	-0.6	-0.7	-0.7	0.6
Glucose	0.6	1.0	1.3	-0.8	-1.0	0.9	1.0	-0.8	-1.0	-1.1	-1.1	1.1
Heart weight	0.7	1.1	2.1	-0.4	0.2	1.4	1.1	-1.4	-1.4	-1.0	-0.7	0.9
Delay discount hyperbolic model param	0.0	0.0	0.2	-0.4	-0.2	0.1	-0.1	-0.1	0.0	0.2	0.2	0.1
Intermittent access intake day 1-15 change	0.1	0.3	0.6	-0.8	-0.8	0.5	0.5	-0.5	-0.5	-0.5	-0.3	0.5
Intermittent access intake escalation	0.1	0.5	1.0	-1.0	-0.9	0.7	0.7	-0.7	-0.7	-0.7	-0.4	0.6
Intermittent access intake escalation 2	0.4	0.7	1.2	-1.1	-1.0	0.8	0.8	-0.8	-0.8	-0.9	-0.6	0.7
Intermitt. access day 1 inactive lever presses	0.0	0.6	1.1	0.4	-0.2	-0.9	-0.9	0.9	1.0	0.8	0.7	-0.8
Intermitt. access day 15 inactive lever presses	0.0	0.2	0.9	-0.9	-0.2	0.6	0.4	-0.6	-0.6	-0.1	0.1	-0.1
Intermitt. access escalation Index	0.0	0.1	0.1	0.3	0.3	0.3	0.1	-0.3	-0.2	0.2	-0.1	0.2
Intermittent access day 1 total infusions	0.7	2.0	3.0	0.8	0.7	-1.6	-1.6	1.6	1.7	1.6	1.2	-1.3
Intermittent access day 15 total infusions	0.3	0.7	1.1	0.3	0.2	-1.0	-1.0	0.9	1.1	1.0	0.9	-0.8
Intermittent access terminal intake (last 3 days)	0.2	0.4	0.9	0.2	-0.1	-0.7	-0.8	0.7	1.0	0.7	0.5	-0.6
Intermittent access total infusions	0.7	0.9	1.4	0.1	0.1	-1.1	-1.1	1.1	1.2	1.1	0.9	-0.9
Intermittent access day 1 locomotion	1.3	2.5	4.1	1.2	0.3	-1.9	-1.8	1.9	2.0	1.6	1.4	-1.3
Intermittent access day 15 total locomotion	0.3	1.2	2.1	0.3	-0.1	-1.4	-1.3	1.4	1.4	1.2	1.0	-1.0
Intermittent access total locomotion	0.1	0.1	0.4	-0.3	-0.7	-0.4	-0.4	0.4	0.5	0.2	-0.0	-0.2
Intermittent access standard deviation	0.0	0.2	0.5	-0.7	-0.7	-0.3	-0.3	0.2	0.4	0.3	0.3	-0.1
Left kidney weight	1.1	9.1	12.0	-3.5	-3.2	3.1	2.9	-3.1	-3.0	-3.0	-2.8	2.6
Right kidney weight	1.2	8.7	10.8	-2.9	-2.5	3.2	3.0	-3.3	-3.3	-2.9	-2.6	2.7
Cocaine induced anxiety	0.1	0.2	0.9	1.0	0.3	-0.4	-0.4	0.4	0.3	0.4	0.4	-0.4
Post-drug Anxiety	1.8	2.0	3.2	1.8	1.2	-1.4	-1.3	1.4	1.2	1.5	1.5	-1.4
Baseline Anxiety	0.4	0.6	0.8	0.7	0.9	-0.8	-0.8	0.9	0.8	0.8	0.7	-0.7
Tail length	0.2	1.2	1.7	1.1	1.1	-1.2	-1.0	1.3	1.2	1.0	1.0	-0.9
Length with tail	0.0	0.1	0.3	-0.5	-0.5	0.0	0.2	-0.0	-0.1	-0.2	-0.2	0.2
Length without tail	0.9	4.7	6.6	-2.5	-2.6	2.1	2.1	-2.2	-2.3	-1.9	-1.8	1.9
Times rat made contact with spout	0.2	0.2	0.5	0.0	0.2	-0.4	-0.6	0.4	0.5	0.5	0.7	-0.6
Lifetime Intake	0.5	0.7	1.1	0.1	0.1	-1.0	-0.9	0.9	1.0	1.0	0.7	-0.8
Liver weight, left	3.2	5.6	6.1	-2.1	-2.1	2.5	2.4	-2.4	-2.4	-2.4	-2.4	2.4
Liver weight, right	2.5	4.5	6.2	-1.7	-2.2	2.0	2.1	-2.0	-1.9	-2.2	-2.5	2.2
Locomotor activity	4.5	7.0	7.8	-2.8	-2.8	2.7	2.6	-2.6	-2.5	-2.6	-2.7	2.5
Locomotor testing distance	2.3	5.6	7.5	-2.7	-2.5	2.3	2.3	-2.3	-2.3	-2.2	-2.3	2.3
Locomotor testing rearing	0.6	2.1	2.6	-1.5	-1.4	1.5	1.5	-1.5	-1.3	-1.2	-1.6	1.6
Locomotion in novel chamber	0.2	0.3	0.5	0.1	-0.6	-0.5	-0.6	0.5	0.6	0.7	0.6	-0.5
Locomotion in novel chamber post-restriction	0.1	0.3	0.7	0.8	0.9	-0.4	-0.4	0.4	0.4	0.2	0.1	-0.4
Fecal boli incidents, locomotor time 1	0.3	0.8	1.3	1.1	1.1	-0.9	-0.9	0.9	1.1	0.7	0.8	-0.7
Change in fecal boli incidents, locomotor task	1.0	1.1	3.5	-1.8	-1.9	0.7	0.6	-0.7	-0.5	-0.5	-0.9	0.7
Time >=10cm from walls, locomotor time 1	0.6	0.8	1.2	-0.6	-1.1	0.8	0.8	-0.8	-0.7	-0.9	-1.1	1.1
Bouts of movement, locomotor time 1	0.1	0.1	0.4	0.2	0.0	0.3	0.5	-0.3	-0.6	-0.4	-0.2	0.2
Total resting periods, locomotor time 1	0.0	0.0	0.2	0.2	0.0	0.1	0.3	-0.1	-0.4	-0.3	-0.0	-0.0
Rest time, locomotor task time 1	0.3	0.4	0.7	0.7	0.0	-0.8	-0.7	0.9	0.7	0.3	0.5	-0.7
Distance moved, locomotor task time 1	0.0	0.1	0.2	0.2	0.4	0.4	0.2	-0.4	-0.4	0.0	-0.1	0.2
Vertical activity count, locomotor time 1	0.0	0.1	0.3	0.5	0.5	-0.1	-0.0	0.1	0.1	0.1	-0.0	0.1
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.1	0.2	-0.2	-0.0	0.1	0.0	-0.3	-0.1	-0.1	0.1
Bouts of movement, locomotor time 2	0.4	1.2	1.6	-0.5	-0.2	1.2	1.2	-1.3	-1.3	-1.2	-1.3	1.2
Total resting periods, locomotor time 2	0.3	1.3	1.7	-0.6	-0.3	1.3	1.2	-1.3	-1.2	-1.3	-1.3	1.2
Rest time, locomotor task time 2	0.4	0.6	1.3	0.3	0.2	-1.0	-0.9	1.0	1.1	0.7	0.6	-0.7
Distance moved, locomotor task time 2	0.2	0.2	0.5	0.0	0.2	0.7	0.5	-0.7	-0.6	-0.4	-0.4	0.5
Vertical activity count, locomotor time 2	0.2	0.6	1.1	0.9	1.1	-0.8	-0.7	0.8	0.8	0.6	0.5	-0.6
Light reinforcement 1	0.9	4.1	5.6	-1.3	-1.5	2.3	2.1	-2.2	-2.4	-2.1	-2.0	2.1
Light reinforcement 2	0.5	1.1	1.7	0.2	-0.3	-1.1	-1.2	1.1	1.3	0.9	1.2	-1.1
Bone: marrow area	2.2	5.4	7.8	-2.3	-2.8	2.2	2.3	-2.2	-2.2	-2.2	-2.3	2.3
Bone: maximum diameter	2.1	4.2	6.9	-2.6	-2.6	1.9	1.9	-1.9	-1.8	-1.8	-1.8	1.8
Bone: maximum force	0.4	0.7	1.6	-1.1	-1.3	0.7	0.7	-0.8	-0.7	-0.8	-0.8	0.7
Bone: maximum moment	0.2	0.4	1.5	-1.0	-1.2	0.4	0.5	-0.5	-0.4	-0.5	-0.5	0.4
Mean time between licks in bursts	0.2	1.3	1.9	0.7	0.8	-1.3	-1.2	1.3	1.4	1.1	1.0	-1.1
Mean num. licks in bursts	0.7	1.8	3.1	-1.8	-1.6	1.4	1.2	-1.4	-1.3	-1.1	-0.9	1.0
Cd content in liver	1.6	1.7	5.7	1.6	2.4	-0.9	-1.2	0.9	1.2	1.1	1.1	-0.9
Co content in liver	1.6	1.8	3.2	1.8	1.5	-1.1	-1.4	1.0	1.2	1.3	1.4	-1.3
Cu content in liver	0.0	0.0	0.1	0.0	-0.3	0.2	0.1	-0.4	-0.2	-0.2	-0.0	0.1
Fe content in liver	0.3	0.4	0.6	-0.7	-0.1	0.7	0.7	-0.8	-0.7	-0.7	-0.4	0.6
K content in liver	0.7	0.7	1.5	-1.0	-0.4	1.1	0.9	-1.2	-1.1	-0.6	-0.4	0.6
Mg content in liver	0.8	0.9	1.3	-0.8	-0.7	1.1	1.0	-1.1	-1.1	-0.8	-0.8	0.8
Mn content in liver	0.2	0.2	1.1	-0.8	-1.1	-0.0	-0.1	-0.1	0.1	0.0	0.1	-0.2
Na content in liver	4.9	5.6	7.0	-1.9	-1.8	2.5	2.5	-2.5	-2.6	-2.6	-2.3	2.3
Rb content in liver	1.2	1.4	2.0	-1.4	-0.7	1.3	1.3	-1.3	-1.3	-1.2	-1.0	1.1
Se content in liver	0.1	0.1	0.3	-0.2	0.3	-0.3	-0.4	0.3	0.4	0.3	0.5	-0.5
Sr content in liver	0.9	0.8	1.4	1.1	1.2	-0.8	-0.8	0.8	0.8	0.8	0.8	-0.8
Zn content in liver	0.0	0.0	0.1	0.2	0.0	0.2	0.1	-0.2	-0.2	0.2	0.2	-0.1
Bone: minimum diameter	0.1	0.1	0.8	-0.3	-0.9	-0.1	-0.1	-0.0	0.1	0.1	0.0	-0.0
Time in familiar zone, hab. session 1	0.0	0.1	0.1	0.3	0.3	-0.0	-0.2	0.1	0.0	0.3	0.4	-0.1
Time in novel zone, hab. session 1	0.1	0.1	0.2	-0.1	-0.0	-0.4	-0.3	0.4	0.4	0.2	0.2	-0.3
Total zone transitions, hab. session 1	0.3	0.4	2.0	0.7	1.4	-0.2	-0.3	0.2	0.2	0.4	0.6	-0.4
Total locomotion distance, hab. session 1	0.1	0.1	1.0	0.3	1.0	0.2	0.1	-0.2	-0.3	-0.0	0.2	-0.0
Locomotion velocity, hab. session 1	0.1	0.1	0.4	0.0	0.7	0.4	0.3	-0.4	-0.5	-0.1	0.1	0.1
Time in familiar zone, hab. session 2	0.2	0.2	0.4	0.2	0.6	-0.3	-0.3	0.4	0.3	0.4	0.6	-0.5
Time in novel zone, hab. session 2	0.2	0.2	1.0	-0.5	-1.0	0.1	0.2	-0.2	-0.1	-0.3	-0.6	0.4
Total zone transitions, hab. session 2	0.3	0.4	0.6	0.6	0.8	0.7	0.6	-0.7	-0.7	-0.4	-0.4	0.5
Total locomotion distance, hab. session 2	0.4	0.5	0.9	0.4	0.7	0.9	0.7	-0.9	-0.9	-0.6	-0.4	0.6
Locomotion velocity, hab. session 2	0.2	0.3	0.6	0.4	0.7	0.7	0.5	-0.7	-0.7	-0.4	-0.2	0.4
Novel to familiar place preference ratio	1.1	1.4	1.7	-0.9	-1.2	1.2	1.2	-1.3	-1.2	-1.3	-1.3	1.2
Novelty place preference	1.2	1.5	1.7	-1.0	-1.3	1.2	1.2	-1.3	-1.2	-1.3	-1.3	1.2
Time in novel zone, NPP test	1.5	1.8	2.5	-1.2	-1.6	1.3	1.3	-1.4	-1.2	-1.4	-1.4	1.3
Total zone transitions, NPP test	0.2	0.4	0.6	0.3	0.8	0.8	0.6	-0.7	-0.7	-0.4	-0.3	0.4
Total locomotion distance, NPP test	0.4	0.6	1.1	-0.1	0.6	1.0	0.9	-1.0	-1.1	-0.6	-0.5	0.6
Locomotion velocity, NPP test	0.3	0.4	1.3	0.3	1.2	0.7	0.6	-0.7	-0.8	-0.2	-0.1	0.3
Intraocular pressure	0.1	0.1	0.4	0.1	0.6	-0.2	-0.3	0.3	0.3	0.2	0.3	-0.2
Delta distance traveled before/after self-admin	3.2	3.5	6.3	-2.4	-2.5	1.6	1.8	-1.6	-1.8	-1.5	-1.7	1.7
Delta ambulatory time before/after self-admin	1.2	2.1	4.9	-2.2	-2.1	1.1	1.2	-1.1	-1.3	-1.1	-1.1	1.2
Parametrial fat weight	1.8	4.2	5.4	2.2	2.3	-2.0	-2.0	2.1	2.1	1.9	1.7	-1.9
Pavlov. Cond. lever latency	0.3	0.4	1.5	-1.2	-1.2	-0.4	-0.1	0.5	0.3	-0.0	-0.2	0.0
Pavlov. Cond. magazine entry latency	2.7	3.5	9.0	3.0	2.6	-1.4	-1.6	1.4	1.4	1.5	1.6	-1.5
Pavlov. Cond. change in total contacts	0.5	0.6	2.7	1.6	1.1	-0.3	-0.5	0.3	0.4	0.5	0.5	-0.4
Pavlov. Cond. index score	2.0	2.5	7.6	2.7	2.4	-1.1	-1.2	1.0	1.1	1.2	1.3	-1.2
Pavlov. Cond. latency score	1.5	1.8	6.0	2.5	2.2	-0.8	-1.0	0.7	0.8	1.0	1.1	-1.0
Pavlov. Cond. lever contacts	0.5	0.5	2.6	1.6	1.3	-0.1	-0.3	0.0	0.2	0.3	0.4	-0.3
Pavlov. Cond. magazine entry number	2.8	3.6	8.7	-3.0	-2.5	1.5	1.7	-1.6	-1.6	-1.6	-1.6	1.5
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.6	-0.5	0.1	0.7	0.7	-0.8	-0.6	-0.7	-0.7	0.7
Pavlov. Cond. lever-magazine prob. diff.	1.7	2.1	7.1	2.7	2.2	-0.9	-1.1	0.9	0.9	1.0	1.1	-1.0
Pavlov. Cond. response bias	1.6	2.0	6.3	2.5	2.1	-0.9	-1.1	0.9	0.9	1.1	1.1	-1.0
Pavlov. Cond. lever latency	0.4	0.6	1.2	-1.1	-0.7	0.7	0.8	-0.7	-0.7	-0.8	-0.6	0.6
Pavlov. Cond. magazine entry latency	4.6	6.5	7.2	2.2	2.4	-2.6	-2.6	2.6	2.5	2.6	2.7	-2.7
Pavlov. Cond. change in total contacts	0.7	1.6	1.8	1.2	1.3	-1.3	-1.3	1.2	1.3	1.3	1.3	-1.2
Pavlov. Cond. index score	1.6	2.5	2.9	1.6	1.6	-1.6	-1.6	1.5	1.5	1.7	1.6	-1.6
Pavlov. Cond. latency score	1.2	1.9	2.2	1.2	1.3	-1.4	-1.4	1.4	1.3	1.5	1.5	-1.4
Pavlov. Cond. lever contacts	0.4	0.6	1.2	1.1	0.6	-0.8	-0.8	0.7	0.8	0.8	0.7	-0.6
Pavlov. Cond. magazine entry number	4.1	5.3	5.7	-2.0	-2.2	2.4	2.4	-2.4	-2.3	-2.4	-2.4	2.4
Pavlov. Cond. intertrial magazine entries	0.7	1.6	2.0	-1.3	-0.9	1.4	1.4	-1.4	-1.3	-1.2	-1.2	1.3
Pavlov. Cond. lever-magazine prob. diff.	2.0	3.0	3.3	1.7	1.7	-1.7	-1.8	1.7	1.7	1.8	1.8	-1.7
Pavlov. Cond. response bias	2.2	3.0	4.3	2.1	1.8	-1.7	-1.7	1.6	1.7	1.7	1.6	-1.6
Time in closed arm before self-admin	0.1	0.1	0.4	0.5	0.6	-0.1	-0.3	0.1	0.2	0.2	0.4	-0.3
Time in closed arm after self-admin	0.2	0.2	0.4	0.6	0.6	-0.4	-0.5	0.4	0.4	0.6	0.4	-0.5
Time in open arm before self-admin	0.6	0.7	1.4	-1.0	-1.2	0.8	0.8	-0.8	-0.8	-0.8	-0.8	0.8
Time in open arm after self-admin	0.3	0.3	0.9	-0.9	-1.0	0.4	0.5	-0.4	-0.5	-0.4	-0.3	0.4
Bone: periosteal estimation	1.4	3.4	6.9	-2.2	-2.6	1.7	1.6	-1.7	-1.6	-1.7	-1.7	1.7
Bone: periosteal perimeter	2.1	4.2	7.2	-2.3	-2.7	1.8	1.9	-1.9	-1.7	-2.0	-2.0	2.0
Bone: post-yield work	0.2	0.4	0.5	-0.4	-0.3	0.6	0.7	-0.7	-0.7	-0.5	-0.7	0.7
Progressive ratio test 1 active lever presses	0.2	0.4	0.6	0.2	0.4	-0.7	-0.7	0.7	0.8	0.6	0.5	-0.6
Progressive ratio test 1 breakpoint	0.2	0.4	0.7	0.3	0.4	-0.7	-0.8	0.7	0.8	0.7	0.5	-0.7
Progressive ratio test 1 inactive lever presses	1.1	2.8	4.3	0.8	0.6	-1.9	-1.9	1.9	2.0	2.1	1.7	-1.5
Progressive ratio test 2 active lever presses	0.1	0.2	0.9	-0.9	-0.4	0.3	0.2	-0.4	-0.2	-0.2	-0.3	0.3
Progressive ratio test 2 breakpoint	0.1	0.2	0.9	-0.9	-0.4	0.3	0.2	-0.4	-0.2	-0.2	-0.2	0.2
Progressive ratio test 2 inactive lever presses	0.2	0.6	0.9	-0.4	0.1	-0.8	-0.9	0.8	0.9	0.9	0.9	-1.0
Incentive Sensitization - Responses	0.3	0.8	1.5	-1.2	-0.7	0.9	0.8	-0.9	-0.9	-0.8	-0.7	0.7
Incentive Sensitization - Breakpoint	0.3	0.6	1.3	-1.1	-0.6	0.9	0.7	-0.9	-0.8	-0.7	-0.6	0.7
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	-0.4	-0.4	0.2	0.3	-0.0	-0.4	-0.2	-0.2	0.4
Progressive ratio	0.2	0.6	2.0	1.4	0.7	-0.6	-0.6	0.6	0.7	0.8	0.6	-0.4
Food seeking constrained by brief footshock	0.4	0.5	1.0	-0.5	-0.3	0.9	0.8	-0.8	-0.6	-0.8	-1.0	0.7
Seeking ratio, punishment vs. effort	2.0	4.5	6.2	-2.5	-1.6	2.2	2.1	-2.1	-2.0	-2.3	-2.2	2.0
Retroperitoneal fat weight	0.3	1.3	3.8	1.1	1.9	-0.9	-0.8	0.8	0.6	1.0	1.3	-1.2
Reaction time number correct	0.8	2.7	3.4	-1.4	-1.2	1.7	1.7	-1.7	-1.6	-1.7	-1.7	1.8
Reaction time mean minus median	0.1	0.4	0.7	0.8	0.6	-0.6	-0.7	0.6	0.4	0.7	0.8	-0.7
Reaction time mean minus median AUC	0.2	1.2	2.1	1.0	1.0	-1.0	-1.1	1.0	0.8	1.2	1.4	-1.2
Reaction time num false alarms	0.1	0.2	0.3	0.4	0.6	-0.4	-0.4	0.4	0.3	0.4	0.6	-0.4
Reaction time num false alarms AUC	0.0	0.0	0.1	-0.2	0.3	0.1	0.1	-0.1	-0.1	0.0	0.3	-0.1
Reaction time trials correct on left	0.8	2.7	3.4	-1.4	-1.2	1.7	1.7	-1.7	-1.6	-1.7	-1.7	1.8
Reaction time trials on left	0.8	2.6	3.3	-1.4	-1.2	1.7	1.7	-1.7	-1.6	-1.7	-1.7	1.8
Reaction time mean	2.0	4.5	5.1	1.9	1.6	-2.2	-2.3	2.2	2.1	2.2	2.3	-2.3
Reaction time mean AUC	1.7	4.1	4.7	1.9	1.6	-2.1	-2.2	2.1	2.0	2.1	2.1	-2.1
Median of all reaction times	4.0	6.3	7.1	2.2	1.9	-2.7	-2.7	2.6	2.5	2.6	2.6	-2.7
Reaction time omissions	0.0	0.1	0.2	-0.0	0.5	-0.0	-0.2	0.0	-0.0	0.3	0.5	-0.3
Reaction time false alarm rate	0.8	1.1	1.6	0.7	1.0	-1.0	-1.0	1.0	0.9	1.1	1.3	-1.2
Reaction time premature initiation rate	0.8	1.2	1.5	-1.1	-0.9	1.2	1.1	-1.1	-1.2	-1.0	-1.0	1.2
Reaction time premature initiations	1.0	3.1	4.1	-1.6	-1.4	1.9	1.8	-1.8	-1.9	-1.7	-1.7	2.0
Std. dev. reaction times	0.7	2.5	3.4	1.5	1.5	-1.5	-1.6	1.5	1.4	1.7	1.8	-1.7
Reaction time trials completed	0.8	2.6	3.3	-1.4	-1.2	1.7	1.7	-1.7	-1.6	-1.7	-1.7	1.8
Reaction time trials AUC	0.6	2.3	2.9	-1.3	-1.0	1.6	1.6	-1.6	-1.5	-1.6	-1.5	1.7
Run reversals in cocaine runway, females	0.1	0.1	0.1	-0.3	-0.3	0.3	0.1	-0.3	-0.1	-0.2	0.3	-0.3
Run reversals in cocaine runway, males	0.5	0.6	0.8	-0.2	0.6	0.9	0.9	-0.9	-0.9	-0.9	-0.7	0.7
Latency to leave start box in cocaine runway	1.4	2.0	2.9	-1.1	-1.2	1.3	1.4	-1.3	-1.3	-1.6	-1.7	1.7
Latency to leave start box in cocaine runway, F	0.5	0.7	1.1	-0.7	-0.5	0.7	0.8	-0.7	-0.8	-1.0	-1.0	1.0
Latency to leave start box in cocaine runway, M	4.3	4.1	4.8	-1.7	-1.9	2.0	2.0	-2.0	-1.9	-2.2	-2.2	2.2
Std. dev. time between licks in bursts	0.0	0.1	0.1	0.1	0.1	0.2	0.2	-0.2	-0.1	-0.3	-0.3	0.3
Total sessions with >9 infusions	0.2	0.3	0.5	-0.1	0.0	-0.7	-0.5	0.7	0.7	0.7	0.2	-0.5
Short access day 1 total inactive lever presses	0.1	0.2	0.7	-0.9	-0.7	-0.5	-0.2	0.5	0.4	0.5	-0.1	-0.2
Short access day 10 total inactive lever presses	0.1	0.8	1.8	0.3	0.4	-0.9	-0.9	0.9	0.9	1.3	1.1	-1.0
Short access day 1 total infusions	0.1	0.2	0.6	-0.3	-0.8	-0.5	-0.2	0.5	0.5	0.3	-0.5	0.1
Short access day 10 total infusions	1.5	2.5	3.3	1.1	0.9	-1.8	-1.7	1.8	1.8	1.8	1.5	-1.5
Short access total infusions	0.8	1.2	1.9	0.5	0.5	-1.3	-1.2	1.3	1.4	1.3	0.8	-1.0
Short access day 1 locomotion	0.0	0.0	0.1	-0.1	-0.3	-0.2	-0.1	0.1	0.3	-0.1	-0.4	0.2
Short access day 10 total locomotion	0.1	0.4	0.8	-0.2	-0.9	-0.8	-0.7	0.8	0.9	0.3	0.3	-0.2
Short access total locomotion	0.4	0.6	1.3	0.3	-0.2	-1.0	-1.0	1.0	1.2	0.7	0.5	-0.6
One hour access (0.3 mA shock)	0.3	0.4	1.2	-1.1	-0.9	0.4	0.5	-0.4	-0.4	-0.2	-0.6	0.3
Compulsive drug intake	0.8	1.1	2.6	-1.6	-1.2	1.0	1.0	-0.9	-1.0	-0.9	-1.0	0.8
One hour access (shock baseline)	0.2	0.6	0.9	0.5	0.6	-0.7	-0.8	0.7	0.7	0.9	0.9	-0.8
Social response proportion	0.3	0.3	1.2	-0.5	-1.1	0.5	0.4	-0.5	-0.2	-0.8	-0.4	0.5
Social responses	0.1	0.2	0.3	-0.3	-0.2	0.6	0.4	-0.5	-0.5	-0.4	-0.3	0.3
Social time	0.1	0.2	0.6	-0.7	-0.8	0.5	0.3	-0.6	-0.4	0.0	-0.0	0.3
Soleus weight	17.5	51.6	56.2	-6.5	-6.5	7.3	7.4	-7.3	-7.3	-7.4	-7.5	7.4
Bone: stiffness	0.9	1.7	3.0	-1.7	-1.3	1.2	1.3	-1.2	-1.2	-1.2	-1.3	1.3
Tibialis anterior weight	14.6	50.4	55.1	-7.4	-7.1	7.0	7.1	-7.1	-7.0	-7.0	-7.1	7.0
Time to tail flick, vehicle, before self-admin	0.4	0.5	2.6	1.6	1.3	-0.2	-0.4	0.2	0.5	0.2	0.3	-0.3
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.6	-0.2	-0.8	-0.1	-0.3	0.2	0.3	0.2	-0.0	0.0
Time to tail flick, test, before self-admin	1.6	1.8	3.6	1.9	1.6	-1.2	-1.4	1.2	1.3	1.1	1.1	-1.1
Time to tail flick, test, after self-admin	1.9	2.0	2.3	1.5	1.3	-1.5	-1.5	1.5	1.4	1.4	1.2	-1.2
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.9	-0.6	-0.9	-0.5	-0.3	0.5	0.4	0.4	0.1	-0.1
Delta time to tail flick, test, before/after SA	0.1	0.1	0.6	-0.7	-0.8	-0.1	-0.0	0.1	-0.1	0.1	-0.0	-0.0
Tibia length	0.1	0.2	1.0	-0.2	-1.0	-0.5	-0.3	0.4	0.4	0.5	0.3	-0.2
Ambulatory time before self-admin	0.2	0.5	0.8	0.6	0.6	-0.8	-0.6	0.9	0.8	0.7	0.6	-0.7
Ambulatory time after self-admin	0.8	1.3	3.6	-1.9	-1.7	0.7	1.0	-0.7	-1.0	-0.7	-0.9	0.9
Bone: tissue strength	0.9	1.0	1.2	0.8	0.4	-1.1	-1.1	1.1	1.1	1.0	1.0	-1.1
Total heroin consumption	1.2	1.5	2.3	-1.0	-0.3	1.2	1.5	-1.2	-1.4	-1.4	-1.2	1.2
Bone: trabecular number	0.6	1.0	2.9	1.1	1.7	-0.9	-0.9	0.7	1.0	0.9	0.8	-0.9
Bone: trabecular spacing	0.0	0.0	0.0	0.2	-0.1	-0.0	-0.0	0.1	-0.1	-0.1	0.1	-0.1
Bone: trabecular thickness	0.1	0.1	0.4	-0.6	-0.4	-0.1	-0.1	0.1	0.2	0.2	0.3	-0.1
Bone: trabecular tissue density	4.6	8.1	15.1	-3.9	-3.5	2.6	2.7	-2.6	-2.7	-2.5	-2.3	2.4
Water consumed over 24 hours	0.2	0.5	0.6	0.5	0.2	-0.7	-0.8	0.7	0.8	0.7	0.8	-0.8
Number of responses in last shaping day	0.1	0.1	0.4	-0.4	-0.6	0.3	0.2	-0.3	-0.2	-0.4	-0.3	0.3