Hub : Genes

Entpd4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Entpd4 0.06 0.06 4.2e-05 0.05 0.05 0.05 0.05 3.9e-05 2.0e-05 2.6e-05 2.0e-05
2 PL gene expression Entpd4 0.06 0.06 2.0e-05 0.04 0.04 0.04 0.04 1.2e-05 2.1e-05 1.5e-05 2.3e-05
3 pVTA gene expression Entpd4 0.06 0.06 2.5e-04 0.05 0.05 0.05 0.05 1.4e-04 9.4e-05 9.5e-05 1.1e-04
4 NAcc gene expression Entpd4 0.02 0.02 2.6e-03 0.01 0.01 0.01 0.01 2.3e-03 2.7e-03 2.8e-03 2.8e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bone: apparent density1.12.02.31.1-1.51.5-1.5
Area under the delay curve0.10.10.2-0.40.3-0.40.3
BMI with tail0.41.51.7-1.31.2-1.21.3
BMI without tail0.00.00.0-0.10.0-0.10.1
Body weight0.72.93.1-1.71.7-1.71.8
Weight adjusted by age0.72.12.2-1.51.4-1.51.4
Bone surface0.51.01.20.9-1.11.1-1.1
Bone volume0.61.11.30.8-1.11.1-1.1
Breakpoint value in progressive ratio session0.10.20.2-0.30.5-0.30.5
Number of licking bursts0.00.00.0-0.00.1-0.1-0.1
Context. condit. distance diff. score0.81.01.11.0-1.01.0-1.0
Locomotion velocity, session 10.20.20.3-0.30.5-0.50.5
Locomotion distance, session 10.00.00.10.30.00.0-0.1
Locomotion velocity, session 20.10.10.30.5-0.20.2-0.1
Locomotion distance, session 20.00.00.10.3-0.10.1-0.1
Locomotion velocity, session 30.60.60.7-0.70.9-0.80.8
Locomotion distance, session 30.00.00.00.1-0.10.1-0.1
Stereotopy head waving bouts, day 30.80.91.0-1.01.0-1.01.0
Stereotopy head waving duration, day 32.53.13.4-1.81.8-1.71.7
Locomotion velocity, session 74.04.44.52.1-2.12.1-2.1
Locomotion distance, session 73.24.14.32.1-2.02.0-2.0
Stereotopy head waving bouts, day 71.31.51.6-1.21.2-1.21.3
Stereotopy head waving duration, day 71.82.32.4-1.51.5-1.51.5
Locomotion velocity, session 80.00.00.10.30.00.10.0
Locomotion distance, session 80.70.91.31.1-0.90.9-0.9
Degree of sensitization distance4.44.74.82.2-2.22.2-2.1
Degree of sensitization stereotypy0.80.91.1-0.91.0-1.01.0
Conditioned locomotion0.10.10.10.4-0.20.2-0.2
Cocaine response after cond. corrected0.20.30.5-0.70.5-0.60.6
Cocaine response after cond. not corrected0.20.30.6-0.80.4-0.50.4
Cocaine response before conditioning0.10.10.20.3-0.40.4-0.4
Saline control response0.10.10.20.2-0.40.4-0.3
Bone: connectivity density2.43.84.11.8-2.02.0-2.0
Bone: cortical apparent density0.00.10.10.1-0.30.2-0.3
Bone: cortical area0.00.00.00.0-0.00.0-0.0
Bone: cortical porosity1.11.21.3-1.01.1-1.11.1
Bone: cortical porosity0.60.60.7-0.60.9-0.80.9
Bone: cortical thickness0.00.00.00.1-0.00.0-0.0
Bone: cortical thickness0.00.10.20.5-0.00.1-0.0
Bone: cortical tissue density0.00.10.10.1-0.30.3-0.3
Condit. Reinf. active minus inactive responses0.60.70.8-0.90.8-0.90.7
Condit. Reinf. active-inactive response ratio2.42.52.8-1.61.6-1.71.5
Condit. Reinf. active responses0.00.00.0-0.10.1-0.10.1
Condit. Reinf. inactive responses2.33.03.21.8-1.71.7-1.7
Incentive salience index mean0.91.11.2-1.11.0-1.11.0
Condit. Reinf. lever presses0.40.50.7-0.80.7-0.80.7
Condit. Reinf. active minus inactive responses0.40.61.21.1-0.70.7-0.7
Condit. Reinf. active-inactive response ratio0.00.00.1-0.10.3-0.20.2
Condit. Reinf. active responses1.11.62.31.5-1.11.2-1.1
Condit. Reinf. inactive responses1.82.73.01.7-1.61.6-1.6
Condit. Reinf. lever presses0.20.30.70.8-0.40.5-0.5
Condit. Reinf. lever reinforcers received0.91.22.01.4-1.01.0-1.0
Conditioned reinforcement - actives0.41.71.71.3-1.31.3-1.3
Conditioned reinforcement - inactives1.74.64.82.1-2.22.1-2.2
Conditioned locomotion0.10.20.30.4-0.40.4-0.5
Patch foraging indifference point 0 sec1.23.43.61.9-1.91.8-1.8
Patch foraging indifference point AUC0.20.40.5-0.50.7-0.60.6
Delay disc. indifference point, 0s delay0.30.30.30.6-0.60.5-0.6
Delay disc. indifference point, 16s delay0.20.20.20.5-0.50.5-0.5
Delay disc. indifference point, 2s delay1.51.71.8-1.31.3-1.31.3
Delay disc. indifference point, 24s delay0.10.20.2-0.40.4-0.50.4
Delay disc. indifference point, 4s delay1.92.12.3-1.51.4-1.41.4
Delay disc. indifference point, 8s delay0.00.00.00.0-0.10.1-0.1
Indifference point function ln k0.00.00.00.1-0.20.1-0.1
Indifference point function log k0.00.00.00.1-0.20.1-0.1
Patch foraging total patch changes 0 sec0.82.52.61.6-1.61.6-1.5
Patch foraging total patch changes 12 sec0.60.81.11.0-0.80.9-0.9
Patch foraging total patch changes 18 sec0.81.82.01.4-1.31.3-1.3
Patch foraging total patch changes 24 sec0.00.00.00.10.1-0.10.1
Patch foraging total patch changes 6 sec0.20.30.40.6-0.50.5-0.5
Patch foraging time to switch 0 sec0.31.01.10.9-1.01.0-1.1
Patch foraging water rate 0 sec0.10.50.6-0.80.6-0.70.7
Patch foraging water rate 12 sec0.20.90.9-0.80.9-1.01.0
Patch foraging water rate 18 sec1.63.64.0-1.81.9-1.92.0
Patch foraging water rate 24 sec0.10.10.2-0.10.3-0.30.4
Patch foraging water rate 6 sec1.92.82.9-1.71.7-1.71.7
Seeking ratio, delayed vs. immediate footshock1.21.71.81.3-1.31.2-1.4
Distance traveled before self-admin0.40.91.0-1.00.9-1.00.8
Distance traveled after self-admin1.73.03.3-1.81.7-1.71.7
Extensor digitorum longus weight13.051.852.1-7.27.2-7.27.2
Bone: elastic displacement0.40.50.70.9-0.70.7-0.7
Bone: elastic work0.20.30.30.6-0.50.5-0.5
Bone: endosteal estimation0.00.10.2-0.40.3-0.30.3
Bone: endosteal perimeter0.00.10.1-0.30.2-0.20.2
Epididymis fat weight0.52.42.51.6-1.61.6-1.5
Delta time in closed arm before/after self-admin4.13.84.41.7-2.11.9-2.1
Delta time in open arm before/after self-admin0.10.10.3-0.00.5-0.20.2
Diff in mean of infusions in LGA sessions0.71.21.6-0.91.3-1.21.1
Delay discount exponential model param0.40.50.60.8-0.70.7-0.7
Extinction: sum of active levers before priming1.52.32.61.6-1.41.5-1.5
Active lever presses in extinction session 60.40.40.60.5-0.70.6-0.8
Bone: final force0.10.20.4-0.60.4-0.40.4
Bone: final moment0.10.20.3-0.50.3-0.40.3
Food consumed during 24 hour testing period0.10.30.30.4-0.50.5-0.6
Glucose0.00.00.0-0.00.0-0.0-0.1
Heart weight0.50.80.90.9-0.90.8-0.9
Delay discount hyperbolic model param0.50.70.80.9-0.80.8-0.8
Intermittent access intake day 1-15 change0.73.64.02.0-1.91.9-1.8
Intermittent access intake escalation0.73.84.22.0-1.91.9-1.9
Intermittent access intake escalation 21.01.71.91.4-1.31.3-1.3
Intermitt. access day 1 inactive lever presses0.00.00.00.1-0.10.1-0.2
Intermitt. access day 15 inactive lever presses0.00.10.10.1-0.30.2-0.3
Intermitt. access escalation Index0.00.10.1-0.40.3-0.30.3
Intermittent access day 1 total infusions0.00.00.0-0.10.0-0.0-0.2
Intermittent access day 15 total infusions1.12.73.01.6-1.61.6-1.7
Intermittent access terminal intake (last 3 days)0.91.51.81.2-1.21.2-1.3
Intermittent access total infusions1.31.51.71.2-1.21.2-1.3
Intermittent access day 1 locomotion0.00.00.00.0-0.10.1-0.1
Intermittent access day 15 total locomotion0.10.50.60.7-0.60.7-0.8
Intermittent access total locomotion0.10.10.20.4-0.30.3-0.4
Intermittent access standard deviation0.10.30.30.6-0.50.6-0.5
Left kidney weight0.00.20.2-0.50.4-0.40.4
Right kidney weight0.00.10.1-0.20.2-0.20.3
Cocaine induced anxiety0.00.00.0-0.10.1-0.10.0
Post-drug Anxiety0.80.91.00.9-0.90.9-1.0
Baseline Anxiety0.30.50.50.6-0.60.7-0.7
Tail length0.31.81.91.4-1.41.4-1.3
Length with tail0.00.10.2-0.30.4-0.40.4
Length without tail1.36.76.9-2.52.6-2.62.6
Times rat made contact with spout0.50.60.70.9-0.70.7-0.8
Lifetime Intake0.70.91.10.9-0.90.9-1.1
Liver weight, left2.03.43.5-1.91.8-1.81.9
Liver weight, right0.50.91.1-0.90.9-0.91.0
Locomotor activity1.32.12.3-1.41.5-1.51.4
Locomotor testing distance0.00.10.10.3-0.30.3-0.3
Locomotor testing rearing0.10.30.40.6-0.60.6-0.5
Locomotion in novel chamber0.50.70.80.9-0.90.8-0.8
Locomotion in novel chamber post-restriction0.30.80.9-0.90.9-1.00.8
Fecal boli incidents, locomotor time 10.61.61.8-1.21.3-1.21.3
Change in fecal boli incidents, locomotor task0.20.30.4-0.60.4-0.50.4
Time >=10cm from walls, locomotor time 10.70.80.80.8-0.90.9-0.9
Bouts of movement, locomotor time 14.55.85.9-2.42.4-2.42.4
Total resting periods, locomotor time 14.95.65.7-2.42.4-2.42.4
Rest time, locomotor task time 11.62.62.8-1.71.6-1.61.6
Distance moved, locomotor task time 11.23.53.82.0-1.81.8-1.8
Vertical activity count, locomotor time 10.21.31.41.1-1.21.1-1.2
Time >=10cm from walls, locomotor time 20.20.40.5-0.70.6-0.70.6
Bouts of movement, locomotor time 21.65.25.4-2.22.3-2.32.3
Total resting periods, locomotor time 21.45.65.7-2.32.4-2.42.4
Rest time, locomotor task time 20.61.11.3-1.11.0-1.01.0
Distance moved, locomotor task time 22.83.74.02.0-1.91.9-1.9
Vertical activity count, locomotor time 20.20.50.50.7-0.70.7-0.7
Light reinforcement 11.15.15.52.1-2.32.4-2.3
Light reinforcement 20.51.01.30.7-1.11.1-1.1
Bone: marrow area0.00.10.1-0.30.2-0.20.2
Bone: maximum diameter0.30.60.6-0.80.8-0.80.8
Bone: maximum force0.30.50.7-0.80.7-0.70.7
Bone: maximum moment0.20.30.5-0.70.5-0.60.5
Mean time between licks in bursts0.42.42.71.4-1.61.6-1.7
Mean num. licks in bursts0.10.40.50.7-0.60.6-0.5
Cd content in liver1.31.41.6-1.31.2-1.21.1
Co content in liver5.36.26.6-2.62.5-2.52.4
Cu content in liver0.50.60.6-0.80.7-0.80.7
Fe content in liver1.62.02.11.4-1.41.4-1.4
K content in liver1.11.01.10.9-1.11.0-1.1
Mg content in liver2.52.82.91.7-1.71.7-1.7
Mn content in liver2.93.24.42.1-1.71.7-1.7
Na content in liver0.91.01.1-0.91.0-1.01.0
Rb content in liver0.00.00.10.2-0.20.2-0.2
Se content in liver1.01.21.21.1-1.11.1-1.1
Sr content in liver0.00.00.00.1-0.10.1-0.1
Zn content in liver0.10.10.10.2-0.30.3-0.4
Bone: minimum diameter0.10.20.2-0.50.4-0.50.5
Time in familiar zone, hab. session 10.00.00.0-0.00.1-0.10.1
Time in novel zone, hab. session 11.11.31.3-1.11.1-1.11.1
Total zone transitions, hab. session 10.20.30.4-0.30.6-0.60.6
Total locomotion distance, hab. session 10.00.00.10.20.10.00.0
Locomotion velocity, hab. session 10.10.10.20.5-0.20.3-0.3
Time in familiar zone, hab. session 22.12.32.8-1.71.5-1.51.5
Time in novel zone, hab. session 20.80.91.21.1-0.90.9-0.9
Total zone transitions, hab. session 21.31.71.8-1.11.4-1.41.3
Total locomotion distance, hab. session 20.20.30.4-0.40.6-0.60.6
Locomotion velocity, hab. session 20.60.80.8-0.80.9-0.90.9
Novel to familiar place preference ratio1.41.92.41.5-1.31.3-1.3
Novelty place preference1.21.52.01.4-1.21.2-1.2
Time in novel zone, NPP test0.70.81.11.1-0.80.9-0.8
Total zone transitions, NPP test0.10.20.40.6-0.40.4-0.4
Total locomotion distance, NPP test2.73.74.82.2-1.81.9-1.9
Locomotion velocity, NPP test2.63.74.82.2-1.81.9-1.8
Intraocular pressure0.40.70.90.9-0.80.8-0.9
Delta distance traveled before/after self-admin3.13.43.6-1.81.9-1.81.9
Delta ambulatory time before/after self-admin2.03.53.6-1.91.9-1.81.9
Parametrial fat weight2.15.05.42.3-2.22.3-2.2
Pavlov. Cond. lever latency0.00.00.0-0.1-0.00.0-0.0
Pavlov. Cond. magazine entry latency0.00.00.10.2-0.10.2-0.1
Pavlov. Cond. change in total contacts1.21.31.4-1.11.2-1.11.2
Pavlov. Cond. index score0.10.10.1-0.10.3-0.30.3
Pavlov. Cond. latency score0.00.00.1-0.00.2-0.20.2
Pavlov. Cond. lever contacts0.00.00.00.1-0.00.1-0.1
Pavlov. Cond. magazine entry number0.40.50.50.5-0.70.7-0.7
Pavlov. Cond. intertrial magazine entries0.10.20.30.5-0.40.4-0.4
Pavlov. Cond. lever-magazine prob. diff.0.20.20.3-0.30.5-0.50.5
Pavlov. Cond. response bias0.10.20.2-0.30.5-0.40.5
Pavlov. Cond. lever latency0.30.50.60.5-0.80.7-0.7
Pavlov. Cond. magazine entry latency0.00.10.10.0-0.20.2-0.3
Pavlov. Cond. change in total contacts0.81.82.1-1.31.4-1.41.3
Pavlov. Cond. index score0.30.50.6-0.70.8-0.70.6
Pavlov. Cond. latency score0.20.40.5-0.70.6-0.60.5
Pavlov. Cond. lever contacts0.10.20.3-0.20.6-0.50.4
Pavlov. Cond. magazine entry number0.00.00.0-0.00.1-0.10.2
Pavlov. Cond. intertrial magazine entries3.57.67.82.7-2.82.8-2.8
Pavlov. Cond. lever-magazine prob. diff.0.50.70.8-0.90.9-0.80.7
Pavlov. Cond. response bias0.20.30.4-0.40.6-0.60.5
Time in closed arm before self-admin1.11.82.3-1.11.5-1.31.5
Time in closed arm after self-admin0.00.00.0-0.10.1-0.10.1
Time in open arm before self-admin0.00.00.0-0.1-0.1-0.1-0.1
Time in open arm after self-admin0.00.00.00.2-0.00.1-0.1
Bone: periosteal estimation0.00.10.1-0.30.2-0.20.2
Bone: periosteal perimeter0.00.00.0-0.10.1-0.20.2
Bone: post-yield work0.10.20.30.5-0.50.5-0.4
Progressive ratio test 1 active lever presses0.10.10.2-0.40.3-0.30.3
Progressive ratio test 1 breakpoint0.10.20.3-0.50.4-0.40.3
Progressive ratio test 1 inactive lever presses0.51.21.71.0-1.11.1-1.3
Progressive ratio test 2 active lever presses0.00.00.10.2-0.20.2-0.3
Progressive ratio test 2 breakpoint0.00.00.10.2-0.20.1-0.3
Progressive ratio test 2 inactive lever presses0.10.50.60.6-0.70.6-0.8
Incentive Sensitization - Responses0.10.40.40.6-0.60.6-0.6
Incentive Sensitization - Breakpoint0.20.50.50.7-0.70.7-0.7
Sum of active levers in priming session hrs 5-60.10.10.10.2-0.30.2-0.3
Progressive ratio0.00.00.0-0.10.1-0.10.1
Food seeking constrained by brief footshock2.12.62.9-1.71.6-1.71.5
Seeking ratio, punishment vs. effort0.41.01.0-1.01.0-1.00.9
Retroperitoneal fat weight0.10.50.60.6-0.70.7-0.6
Reaction time number correct0.30.91.0-0.91.0-1.01.0
Reaction time mean minus median0.00.20.3-0.50.5-0.40.3
Reaction time mean minus median AUC0.00.10.2-0.50.4-0.30.3
Reaction time num false alarms0.00.10.1-0.10.3-0.20.3
Reaction time num false alarms AUC0.00.00.0-0.00.2-0.20.2
Reaction time trials correct on left0.30.91.0-0.91.0-1.01.0
Reaction time trials on left0.20.70.8-0.70.9-0.80.9
Reaction time mean0.10.30.4-0.60.6-0.50.5
Reaction time mean AUC0.20.60.7-0.80.8-0.70.7
Median of all reaction times0.20.30.3-0.60.5-0.50.5
Reaction time omissions1.52.42.51.4-1.61.6-1.6
Reaction time false alarm rate0.10.20.20.5-0.40.4-0.4
Reaction time premature initiation rate1.72.62.8-1.71.5-1.61.6
Reaction time premature initiations1.23.83.9-1.91.9-1.92.0
Std. dev. reaction times0.10.20.3-0.50.5-0.40.4
Reaction time trials completed0.20.70.8-0.70.9-0.80.9
Reaction time trials AUC0.20.60.7-0.70.9-0.80.8
Run reversals in cocaine runway, females2.52.82.91.6-1.71.7-1.7
Run reversals in cocaine runway, males2.02.22.7-1.41.4-1.41.6
Latency to leave start box in cocaine runway0.30.30.4-0.60.7-0.60.5
Latency to leave start box in cocaine runway, F1.11.31.5-1.11.2-1.21.2
Latency to leave start box in cocaine runway, M0.10.10.30.3-0.30.3-0.6
Std. dev. time between licks in bursts0.91.71.71.3-1.31.3-1.3
Total sessions with >9 infusions0.00.10.1-0.30.2-0.20.2
Short access day 1 total inactive lever presses0.10.20.20.4-0.50.4-0.5
Short access day 10 total inactive lever presses0.00.30.40.4-0.50.5-0.6
Short access day 1 total infusions0.00.10.1-0.30.2-0.30.2
Short access day 10 total infusions0.20.40.4-0.70.6-0.60.5
Short access total infusions0.00.00.1-0.30.2-0.20.1
Short access day 1 locomotion0.61.01.0-1.01.0-1.00.9
Short access day 10 total locomotion0.00.00.00.1-0.10.1-0.0
Short access total locomotion0.10.10.2-0.40.3-0.40.4
One hour access (0.3 mA shock)0.70.91.01.0-0.90.9-0.9
Compulsive drug intake0.50.81.11.1-0.90.9-0.7
One hour access (shock baseline)0.00.00.0-0.10.0-0.0-0.1
Social response proportion0.10.10.2-0.10.3-0.30.4
Social responses1.31.72.61.6-1.21.2-1.1
Social time0.40.70.80.9-0.80.8-0.7
Soleus weight1.33.73.9-2.01.9-1.91.9
Bone: stiffness0.71.21.5-1.21.0-1.11.1
Tibialis anterior weight8.428.929.3-5.45.4-5.45.3
Time to tail flick, vehicle, before self-admin0.91.11.41.1-1.01.0-1.2
Time to tail flick, vehicle, after self-admin1.02.02.1-1.41.4-1.51.4
Time to tail flick, test, before self-admin2.62.93.11.8-1.71.7-1.7
Time to tail flick, test, after self-admin2.42.52.91.5-1.71.6-1.5
Delta time to tail flick, vehicle, before/after SA0.30.30.4-0.60.5-0.50.6
Delta time to tail flick, test, before/after SA0.00.00.00.1-0.20.1-0.1
Tibia length1.23.23.51.6-1.91.8-1.8
Ambulatory time before self-admin0.10.30.4-0.50.6-0.60.5
Ambulatory time after self-admin3.86.16.1-2.52.5-2.52.5
Bone: tissue strength0.00.00.10.1-0.30.2-0.2
Total heroin consumption0.70.80.9-0.90.9-0.80.9
Bone: trabecular number1.93.63.91.7-2.01.9-2.0
Bone: trabecular spacing2.02.93.1-1.61.8-1.71.7
Bone: trabecular thickness0.91.21.40.9-1.21.2-1.2
Bone: trabecular tissue density1.22.12.1-1.51.4-1.41.4
Water consumed over 24 hours1.01.92.1-1.51.4-1.41.3
Number of responses in last shaping day0.60.70.9-0.90.8-0.80.8