Hub : Genes

Ndufs8

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression Ndufs8 0.16 0.11 2.7e-05 0.1 0.09 0.1 0.09 8.6e-06 2.6e-05 7.0e-06 1.4e-05
2 OFC intron excision ratio chr1_210572763_210573418 0.16 0.12 9.0e-03 0.07 0.03 0.07 0.09 9.1e-03 7.5e-02 1.0e-02 4.7e-03
3 IC gene expression Ndufs8 0.12 0.09 2.7e-03 0.01 0.03 0.02 0.01 1.3e-01 1.5e-02 5.7e-02 7.4e-02
4 NAcc gene expression Ndufs8 0.06 0.04 4.0e-07 0.03 0.05 0.04 0.04 8.1e-05 9.4e-08 2.0e-07 2.0e-07
5 OFC intron excision ratio chr1_210572763_210573661 0.15 0.11 7.2e-03 0.08 -0.01 0.08 -0.01 5.1e-03 4.7e-01 7.5e-03 8.8e-01
6 pVTA gene expression Ndufs8 0.07 0.05 1.0e-04 0.03 0.05 0.05 0.04 2.4e-03 8.0e-05 1.0e-04 1.9e-04
7 Brain gene expression Ndufs8 0.06 0.04 1.1e-04 0.04 0.04 0.03 0.04 1.6e-04 1.6e-04 4.8e-04 3.3e-04
8 PL gene expression Ndufs8 0.03 0.03 3.2e-03 0.01 0.02 0.02 0.01 3.1e-02 2.0e-03 1.3e-03 1.0e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density1.73.16.80.8-0.3-2.2-2.21.5-2.4-2.60.4
Area under the delay curve0.40.61.00.50.1-0.7-0.80.8-0.8-1.01.0
BMI with tail2.38.012.73.2-1.9-3.4-3.50.5-3.6-3.60.9
BMI without tail0.84.56.42.4-1.9-2.5-2.5-0.6-2.5-2.31.5
Body weight2.410.617.54.2-3.6-3.7-3.6-1.8-3.4-2.92.1
Weight adjusted by age0.30.91.61.1-1.3-0.8-0.7-1.1-0.6-0.31.1
Bone surface3.36.510.82.3-1.6-3.2-3.20.5-3.3-3.21.4
Bone volume1.52.95.91.1-0.5-2.1-2.21.1-2.3-2.40.7
Breakpoint value in progressive ratio session1.32.33.51.9-1.7-1.6-1.5-1.1-1.4-1.11.6
Number of licking bursts0.00.10.30.10.2-0.3-0.30.3-0.3-0.30.6
Context. condit. distance diff. score0.70.91.8-1.21.30.70.71.20.60.3-1.0
Locomotion velocity, session 10.00.00.00.20.1-0.00.00.0-0.0-0.0-0.2
Locomotion distance, session 11.11.42.91.1-0.3-1.4-1.50.6-1.6-1.70.6
Locomotion velocity, session 21.72.03.61.9-1.7-1.4-1.3-1.3-1.2-0.91.5
Locomotion distance, session 21.01.42.41.6-1.0-1.4-1.4-0.3-1.4-1.30.6
Locomotion velocity, session 30.80.92.00.50.2-1.0-1.01.1-1.2-1.4-0.2
Locomotion distance, session 30.10.10.40.20.2-0.2-0.30.3-0.3-0.4-0.6
Stereotopy head waving bouts, day 30.50.61.9-0.30.6-0.5-0.61.4-0.8-1.0-0.1
Stereotopy head waving duration, day 30.40.62.0-1.01.00.20.11.4-0.0-0.3-0.3
Locomotion velocity, session 70.50.51.20.20.1-0.8-0.80.8-0.9-1.1-0.2
Locomotion distance, session 70.30.40.60.8-0.5-0.8-0.8-0.2-0.8-0.7-0.0
Stereotopy head waving bouts, day 70.60.72.2-0.30.6-0.6-0.71.5-0.8-1.1-0.3
Stereotopy head waving duration, day 71.21.52.80.7-0.5-1.5-1.50.8-1.6-1.70.6
Locomotion velocity, session 81.11.32.01.4-1.3-1.2-1.2-0.8-1.1-0.81.3
Locomotion distance, session 80.20.30.9-0.30.80.10.11.0-0.1-0.3-0.7
Degree of sensitization distance0.40.50.80.7-0.5-0.9-0.90.0-0.9-0.90.4
Degree of sensitization stereotypy0.50.51.10.4-0.2-0.9-0.90.6-1.0-1.00.1
Conditioned locomotion1.31.55.41.4-1.8-0.3-0.2-2.30.00.61.1
Cocaine response after cond. corrected0.00.10.1-0.30.40.10.10.40.1-0.0-0.3
Cocaine response after cond. not corrected0.10.10.5-0.20.4-0.1-0.20.7-0.2-0.4-0.3
Cocaine response before conditioning0.10.10.20.1-0.1-0.4-0.40.3-0.4-0.50.3
Saline control response2.43.45.42.0-2.1-1.9-1.8-1.3-1.7-1.32.3
Bone: connectivity density3.86.010.31.9-1.4-3.1-3.10.7-3.2-3.21.4
Bone: cortical apparent density0.10.21.00.6-0.7-0.1-0.0-1.00.10.30.0
Bone: cortical area0.30.51.50.8-0.9-0.2-0.1-1.20.00.30.8
Bone: cortical porosity0.10.10.20.4-0.1-0.3-0.30.1-0.3-0.30.4
Bone: cortical porosity0.30.40.80.8-0.6-0.5-0.5-0.3-0.5-0.40.9
Bone: cortical thickness2.44.011.12.6-2.9-1.0-0.8-3.3-0.40.42.1
Bone: cortical thickness1.11.42.71.4-1.7-0.8-0.7-1.6-0.5-0.11.5
Bone: cortical tissue density0.20.31.30.8-0.9-0.2-0.2-1.1-0.00.20.2
Condit. Reinf. active minus inactive responses0.30.30.60.4-0.0-0.7-0.70.4-0.7-0.8-0.3
Condit. Reinf. active-inactive response ratio0.10.10.3-0.10.2-0.3-0.30.5-0.4-0.5-0.5
Condit. Reinf. active responses0.00.00.20.10.1-0.2-0.20.1-0.2-0.2-0.4
Condit. Reinf. inactive responses0.10.10.2-0.40.30.40.4-0.10.40.4-0.4
Incentive salience index mean0.20.30.50.5-0.0-0.6-0.60.2-0.7-0.7-0.2
Condit. Reinf. lever presses0.00.00.10.10.1-0.00.0-0.20.00.10.0
Condit. Reinf. active minus inactive responses0.50.82.1-0.31.0-0.2-0.31.5-0.5-0.8-1.4
Condit. Reinf. active-inactive response ratio0.91.54.0-1.11.70.70.71.60.4-0.0-2.0
Condit. Reinf. active responses0.70.92.10.40.4-0.9-1.01.3-1.2-1.4-0.6
Condit. Reinf. inactive responses1.21.82.71.2-1.0-1.6-1.60.1-1.6-1.61.2
Condit. Reinf. lever presses1.01.42.51.2-0.6-1.5-1.50.5-1.6-1.60.3
Condit. Reinf. lever reinforcers received0.81.22.60.60.1-1.2-1.31.2-1.4-1.6-0.3
Conditioned reinforcement - actives0.20.91.5-0.70.31.11.1-0.41.11.2-1.1
Conditioned reinforcement - inactives1.02.84.6-2.12.11.61.51.81.30.8-1.7
Conditioned locomotion6.810.112.9-3.63.53.53.42.13.22.6-3.3
Patch foraging indifference point 0 sec0.10.30.7-0.90.60.40.40.70.30.20.0
Patch foraging indifference point AUC0.30.72.21.4-0.9-0.3-0.2-1.5-0.10.20.5
Delay disc. indifference point, 0s delay0.91.02.10.50.2-1.0-1.01.4-1.2-1.50.0
Delay disc. indifference point, 16s delay0.40.61.4-1.01.20.80.71.00.60.3-0.2
Delay disc. indifference point, 2s delay0.30.31.6-0.30.80.0-0.01.3-0.2-0.40.2
Delay disc. indifference point, 24s delay0.20.31.20.3-0.40.10.1-0.80.20.41.1
Delay disc. indifference point, 4s delay0.30.40.60.8-0.1-0.6-0.60.5-0.7-0.80.3
Delay disc. indifference point, 8s delay0.30.51.70.4-0.2-0.6-0.70.3-0.7-0.71.3
Indifference point function ln k1.54.79.3-3.12.42.32.21.72.01.5-1.8
Indifference point function log k1.54.79.3-3.12.42.32.21.72.01.5-1.8
Patch foraging total patch changes 0 sec0.10.20.5-0.70.20.40.40.10.50.50.3
Patch foraging total patch changes 12 sec1.82.54.42.1-1.8-1.5-1.5-1.4-1.3-0.91.8
Patch foraging total patch changes 18 sec0.20.41.00.8-0.5-0.6-0.7-0.2-0.6-0.51.0
Patch foraging total patch changes 24 sec0.20.82.61.0-1.0-0.5-0.4-1.2-0.30.01.6
Patch foraging total patch changes 6 sec1.01.72.91.5-1.0-1.4-1.5-0.3-1.4-1.31.7
Patch foraging time to switch 0 sec1.04.06.51.5-1.1-2.4-2.40.7-2.5-2.51.8
Patch foraging water rate 0 sec2.28.412.7-2.72.33.53.5-0.13.63.4-2.3
Patch foraging water rate 12 sec3.112.317.0-3.33.04.14.10.34.13.8-3.7
Patch foraging water rate 18 sec1.02.23.0-1.51.41.71.70.41.71.5-1.4
Patch foraging water rate 24 sec3.04.37.3-1.61.52.62.7-0.42.72.6-1.3
Patch foraging water rate 6 sec2.53.76.0-1.81.22.32.4-0.52.42.4-1.2
Seeking ratio, delayed vs. immediate footshock0.40.51.10.5-0.1-0.7-0.80.7-0.9-1.00.7
Distance traveled before self-admin0.10.30.60.2-0.0-0.6-0.70.6-0.7-0.80.4
Distance traveled after self-admin0.00.00.1-0.3-0.1-0.2-0.20.1-0.2-0.2-0.0
Extensor digitorum longus weight4.819.335.15.9-5.8-4.0-3.8-4.6-3.2-2.04.5
Bone: elastic displacement1.21.53.6-0.0-0.11.41.4-1.31.61.9-0.2
Bone: elastic work1.11.43.71.7-1.7-0.5-0.4-1.9-0.20.31.2
Bone: endosteal estimation0.71.75.0-1.52.00.50.42.20.1-0.4-1.3
Bone: endosteal perimeter1.53.710.6-2.22.80.70.63.30.2-0.6-2.2
Epididymis fat weight2.211.217.7-4.23.93.63.52.63.12.4-3.0
Delta time in closed arm before/after self-admin0.90.92.71.6-1.2-0.7-0.6-1.2-0.5-0.20.7
Delta time in open arm before/after self-admin0.10.10.3-0.20.1-0.3-0.30.4-0.4-0.50.5
Diff in mean of infusions in LGA sessions0.40.82.70.5-1.0-0.6-0.6-1.0-0.5-0.31.6
Delay discount exponential model param0.40.50.9-0.5-0.00.60.7-0.70.80.9-0.9
Extinction: sum of active levers before priming1.62.43.41.7-1.4-1.9-1.8-0.5-1.8-1.61.0
Active lever presses in extinction session 60.80.82.31.5-1.2-0.6-0.5-1.3-0.4-0.10.7
Bone: final force1.11.82.41.5-1.4-1.5-1.5-0.6-1.4-1.21.3
Bone: final moment1.01.72.41.6-1.4-1.4-1.4-0.7-1.3-1.11.2
Food consumed during 24 hour testing period0.30.50.8-0.80.70.90.90.10.90.8-0.4
Glucose1.42.27.2-1.51.90.20.12.7-0.2-0.9-1.9
Heart weight0.60.93.0-0.40.6-0.7-0.81.7-1.0-1.30.1
Delay discount hyperbolic model param0.30.50.8-0.5-0.10.60.7-0.80.70.9-0.8
Intermittent access intake day 1-15 change0.73.96.6-2.62.22.12.11.31.91.6-1.6
Intermittent access intake escalation0.63.55.9-2.42.02.12.01.11.91.6-1.5
Intermittent access intake escalation 21.52.63.8-2.01.81.71.71.11.61.2-1.7
Intermitt. access day 1 inactive lever presses0.00.00.00.10.00.10.1-0.00.10.1-0.1
Intermitt. access day 15 inactive lever presses0.21.02.9-1.31.40.70.61.70.4-0.0-0.5
Intermitt. access escalation Index1.13.44.6-2.01.92.12.10.72.01.8-1.6
Intermittent access day 1 total infusions0.51.57.2-0.91.4-0.0-0.22.7-0.5-1.1-0.0
Intermittent access day 15 total infusions1.94.78.7-3.02.92.11.92.81.60.9-1.4
Intermittent access terminal intake (last 3 days)1.83.28.0-2.42.51.41.22.80.90.3-1.0
Intermittent access total infusions1.41.75.7-1.61.90.80.62.40.4-0.2-0.6
Intermittent access day 1 locomotion0.30.63.0-0.61.10.1-0.01.7-0.2-0.6-0.4
Intermittent access day 15 total locomotion1.14.47.9-2.72.81.91.72.81.40.8-1.7
Intermittent access total locomotion4.45.211.1-2.83.21.91.73.31.40.5-1.9
Intermittent access standard deviation0.10.71.6-1.31.10.80.71.10.60.3-0.2
Left kidney weight0.43.35.3-2.12.31.81.81.81.51.1-1.9
Right kidney weight0.42.83.9-2.01.91.91.90.81.81.5-1.3
Cocaine induced anxiety0.00.10.3-0.10.3-0.2-0.10.5-0.2-0.3-0.5
Post-drug Anxiety0.30.40.60.5-0.6-0.8-0.7-0.2-0.7-0.60.3
Baseline Anxiety0.20.41.00.6-1.0-0.5-0.5-0.9-0.4-0.20.5
Tail length0.31.85.51.3-2.0-0.6-0.5-2.3-0.20.41.7
Length with tail1.35.812.33.0-3.5-2.0-1.8-3.2-1.4-0.62.3
Length without tail0.84.48.82.9-3.0-1.8-1.7-2.5-1.4-0.81.8
Times rat made contact with spout0.80.91.40.9-0.6-1.2-1.20.2-1.2-1.20.6
Lifetime Intake0.70.93.2-1.21.30.60.41.80.3-0.2-0.5
Liver weight, left0.50.91.5-1.10.61.21.2-0.11.21.20.0
Liver weight, right1.12.03.1-1.81.31.61.60.31.61.4-1.1
Locomotor activity0.91.52.0-1.21.11.41.40.21.41.3-1.2
Locomotor testing distance0.71.72.6-1.31.21.61.60.21.61.4-0.8
Locomotor testing rearing0.31.02.0-1.01.30.70.71.30.50.2-1.4
Locomotion in novel chamber3.95.210.4-3.22.92.22.12.61.81.1-1.7
Locomotion in novel chamber post-restriction1.33.96.0-2.42.51.91.81.91.61.1-2.2
Fecal boli incidents, locomotor time 10.00.10.1-0.00.30.30.30.20.30.20.2
Change in fecal boli incidents, locomotor task0.10.10.20.4-0.3-0.4-0.4-0.1-0.4-0.40.3
Time >=10cm from walls, locomotor time 11.11.44.7-0.91.50.20.02.2-0.2-0.7-1.5
Bouts of movement, locomotor time 10.40.51.91.1-0.9-0.2-0.1-1.40.10.40.3
Total resting periods, locomotor time 10.20.31.10.6-0.50.10.2-1.10.30.60.2
Rest time, locomotor task time 11.52.43.6-1.71.41.91.90.31.81.7-1.0
Distance moved, locomotor task time 10.30.91.70.8-0.2-1.0-1.10.8-1.2-1.31.0
Vertical activity count, locomotor time 10.10.41.4-0.81.00.30.21.20.1-0.30.0
Time >=10cm from walls, locomotor time 20.20.62.9-0.20.40.70.7-0.20.70.7-1.7
Bouts of movement, locomotor time 20.10.41.61.3-0.7-0.5-0.5-0.6-0.4-0.20.5
Total resting periods, locomotor time 20.10.20.90.9-0.4-0.4-0.4-0.1-0.3-0.30.3
Rest time, locomotor task time 20.81.33.1-1.61.60.80.71.80.50.1-0.7
Distance moved, locomotor task time 20.60.72.30.9-1.1-0.3-0.2-1.5-0.00.31.1
Vertical activity count, locomotor time 20.41.03.00.0-0.50.80.9-1.71.11.40.3
Light reinforcement 10.21.01.5-1.20.91.21.20.41.21.0-0.6
Light reinforcement 21.53.35.2-2.11.62.02.00.71.91.6-2.3
Bone: marrow area0.71.75.1-1.52.00.50.42.30.1-0.4-1.4
Bone: maximum diameter0.10.20.4-0.60.50.60.60.10.50.5-0.1
Bone: maximum force1.93.85.82.0-1.3-2.4-2.40.3-2.4-2.41.3
Bone: maximum moment1.83.45.22.0-1.3-2.2-2.20.2-2.3-2.21.1
Mean time between licks in bursts0.10.61.00.9-0.9-0.7-0.7-0.8-0.6-0.41.0
Mean num. licks in bursts0.00.10.20.3-0.3-0.3-0.30.1-0.3-0.4-0.4
Cd content in liver1.51.72.9-1.51.71.21.21.21.00.7-1.5
Co content in liver1.41.73.3-0.80.31.61.6-1.01.71.8-0.9
Cu content in liver0.00.00.1-0.20.10.30.2-0.10.30.2-0.3
Fe content in liver0.10.10.30.5-0.5-0.2-0.2-0.4-0.2-0.10.1
K content in liver0.60.60.90.8-0.6-0.9-0.90.0-0.9-0.90.3
Mg content in liver0.20.20.6-0.60.70.10.10.8-0.0-0.2-0.4
Mn content in liver1.71.93.21.8-1.6-1.4-1.4-1.2-1.2-0.91.3
Na content in liver0.30.40.8-0.3-0.00.60.7-0.70.80.90.0
Rb content in liver0.70.82.1-1.01.30.30.21.50.0-0.4-1.2
Se content in liver0.20.20.7-0.40.5-0.1-0.10.8-0.2-0.4-0.3
Sr content in liver1.21.12.61.2-1.5-0.5-0.4-1.6-0.20.21.3
Zn content in liver0.30.31.00.5-0.7-0.1-0.1-1.00.00.30.7
Bone: minimum diameter0.71.35.0-0.61.6-0.1-0.22.2-0.5-1.0-1.2
Time in familiar zone, hab. session 10.40.51.3-0.50.90.30.21.10.1-0.1-1.1
Time in novel zone, hab. session 10.10.10.80.0-0.4-0.0-0.0-0.50.00.10.9
Total zone transitions, hab. session 10.40.60.90.9-0.7-0.8-0.8-0.3-0.8-0.70.9
Total locomotion distance, hab. session 10.20.30.8-0.70.90.50.50.80.40.1-0.4
Locomotion velocity, hab. session 10.10.10.2-0.30.40.30.20.30.20.1-0.3
Time in familiar zone, hab. session 20.20.20.90.6-0.6-0.1-0.0-0.90.10.30.0
Time in novel zone, hab. session 20.40.40.9-0.00.1-0.6-0.60.9-0.7-1.00.3
Total zone transitions, hab. session 23.03.97.41.7-0.9-2.4-2.40.9-2.6-2.70.9
Total locomotion distance, hab. session 20.60.71.80.30.2-0.9-0.91.0-1.1-1.30.0
Locomotion velocity, hab. session 20.40.51.4-0.00.5-0.6-0.61.2-0.8-1.1-0.3
Novel to familiar place preference ratio0.30.50.80.2-0.3-0.7-0.80.2-0.8-0.90.9
Novelty place preference0.20.30.5-0.1-0.0-0.5-0.60.5-0.6-0.70.7
Time in novel zone, NPP test0.30.30.6-0.1-0.1-0.6-0.60.5-0.7-0.80.8
Total zone transitions, NPP test1.21.82.81.5-0.8-1.6-1.60.2-1.7-1.60.9
Total locomotion distance, NPP test0.10.20.40.30.3-0.3-0.30.6-0.4-0.6-0.3
Locomotion velocity, NPP test0.10.10.20.20.4-0.2-0.20.5-0.3-0.4-0.4
Intraocular pressure0.81.42.5-0.70.71.51.5-0.51.51.6-0.8
Delta distance traveled before/after self-admin0.10.10.3-0.3-0.10.20.3-0.60.30.4-0.3
Delta ambulatory time before/after self-admin0.10.10.7-0.1-0.30.20.2-0.80.30.4-0.1
Parametrial fat weight1.94.58.0-2.62.81.81.72.71.30.7-2.5
Pavlov. Cond. lever latency0.20.30.5-0.50.40.70.70.10.70.6-0.5
Pavlov. Cond. magazine entry latency0.40.51.4-0.20.7-0.5-0.61.2-0.7-0.9-0.1
Pavlov. Cond. change in total contacts0.40.41.3-0.80.90.10.11.2-0.1-0.3-0.8
Pavlov. Cond. index score0.10.10.3-0.40.60.10.10.40.0-0.0-0.3
Pavlov. Cond. latency score0.10.10.2-0.20.4-0.2-0.20.5-0.2-0.3-0.1
Pavlov. Cond. lever contacts0.10.10.10.10.1-0.4-0.40.2-0.4-0.4-0.0
Pavlov. Cond. magazine entry number0.10.10.40.6-0.6-0.2-0.2-0.4-0.2-0.20.2
Pavlov. Cond. intertrial magazine entries0.50.61.1-0.50.10.90.9-0.51.01.1-0.3
Pavlov. Cond. lever-magazine prob. diff.0.10.10.3-0.30.5-0.0-0.00.4-0.0-0.1-0.4
Pavlov. Cond. response bias0.10.10.3-0.60.50.30.20.20.20.2-0.2
Pavlov. Cond. lever latency0.00.00.0-0.00.00.00.0-0.00.0-0.0-0.1
Pavlov. Cond. magazine entry latency3.24.56.52.3-1.7-2.5-2.5-0.4-2.5-2.31.8
Pavlov. Cond. change in total contacts0.30.71.40.5-0.2-1.0-1.00.7-1.1-1.20.5
Pavlov. Cond. index score0.81.31.91.1-0.8-1.4-1.40.1-1.4-1.30.9
Pavlov. Cond. latency score0.60.91.40.9-0.6-1.2-1.20.1-1.2-1.10.8
Pavlov. Cond. lever contacts0.00.00.00.1-0.0-0.2-0.20.1-0.2-0.20.2
Pavlov. Cond. magazine entry number4.15.47.7-2.52.02.82.70.52.72.5-1.8
Pavlov. Cond. intertrial magazine entries0.81.72.8-1.71.31.51.50.61.41.2-1.0
Pavlov. Cond. lever-magazine prob. diff.1.11.62.51.3-1.0-1.6-1.6-0.0-1.6-1.51.0
Pavlov. Cond. response bias1.01.32.01.2-0.8-1.4-1.40.1-1.4-1.40.9
Time in closed arm before self-admin0.30.61.7-1.11.00.40.31.30.1-0.2-0.6
Time in closed arm after self-admin0.10.10.20.00.20.30.3-0.00.30.3-0.5
Time in open arm before self-admin0.30.41.30.7-0.9-0.3-0.2-1.1-0.10.30.8
Time in open arm after self-admin0.60.71.90.6-0.8-0.9-0.9-0.4-0.8-0.71.4
Bone: periosteal estimation0.10.10.4-0.40.60.20.20.60.1-0.0-0.2
Bone: periosteal perimeter0.20.31.1-0.20.6-0.3-0.31.0-0.4-0.7-0.3
Bone: post-yield work2.74.610.40.40.9-2.0-2.23.1-2.6-3.2-0.4
Progressive ratio test 1 active lever presses0.00.10.30.10.10.30.2-0.10.30.3-0.6
Progressive ratio test 1 breakpoint0.00.10.20.10.10.30.2-0.20.30.3-0.5
Progressive ratio test 1 inactive lever presses0.00.10.60.20.00.10.1-0.00.10.1-0.8
Progressive ratio test 2 active lever presses0.91.32.2-1.51.41.10.91.30.80.5-1.2
Progressive ratio test 2 breakpoint1.01.22.1-1.41.41.11.01.20.80.5-1.1
Progressive ratio test 2 inactive lever presses1.96.010.0-3.23.12.42.22.81.91.2-2.4
Incentive Sensitization - Responses0.10.30.7-0.00.0-0.6-0.60.8-0.7-0.8-0.1
Incentive Sensitization - Breakpoint0.10.30.9-0.20.2-0.4-0.41.0-0.5-0.7-0.3
Sum of active levers in priming session hrs 5-61.81.73.8-0.3-0.21.41.5-1.71.62.0-0.3
Progressive ratio1.34.07.91.3-0.7-2.4-2.51.2-2.6-2.81.0
Food seeking constrained by brief footshock0.30.31.00.2-0.4-0.6-0.60.0-0.6-0.61.0
Seeking ratio, punishment vs. effort1.12.54.7-1.30.82.02.0-0.72.12.2-0.4
Retroperitoneal fat weight5.825.844.7-6.76.15.14.94.54.43.2-4.9
Reaction time number correct0.10.31.20.7-0.5-0.00.1-1.10.20.5-0.6
Reaction time mean minus median0.42.85.62.4-1.5-2.0-1.9-0.5-1.9-1.60.7
Reaction time mean minus median AUC0.31.74.42.1-1.4-1.4-1.3-1.0-1.2-0.90.4
Reaction time num false alarms0.20.40.9-0.0-0.30.50.6-1.00.70.90.3
Reaction time num false alarms AUC0.20.51.60.7-1.0-0.2-0.1-1.30.00.31.0
Reaction time trials correct on left0.10.31.20.7-0.5-0.00.1-1.10.20.5-0.6
Reaction time trials on left0.10.41.50.8-0.7-0.10.0-1.20.20.5-0.5
Reaction time mean0.10.20.50.10.1-0.5-0.60.5-0.6-0.70.1
Reaction time mean AUC0.10.20.60.00.2-0.5-0.50.7-0.6-0.7-0.1
Median of all reaction times0.20.20.8-0.50.5-0.2-0.30.9-0.4-0.6-0.0
Reaction time omissions1.42.34.52.1-1.8-1.7-1.6-1.2-1.5-1.10.7
Reaction time false alarm rate0.20.20.90.1-0.50.10.1-0.70.20.40.9
Reaction time premature initiation rate1.92.94.62.1-2.0-1.8-1.7-1.6-1.5-1.11.5
Reaction time premature initiations1.23.56.92.6-2.5-1.7-1.6-2.4-1.3-0.81.3
Std. dev. reaction times0.31.01.81.3-0.8-1.2-1.2-0.1-1.2-1.10.4
Reaction time trials completed0.10.41.50.8-0.7-0.10.0-1.20.20.5-0.5
Reaction time trials AUC0.10.31.10.7-0.5-0.00.0-1.00.10.4-0.5
Run reversals in cocaine runway, females1.11.32.01.3-0.8-1.4-1.40.2-1.4-1.40.3
Run reversals in cocaine runway, males0.30.30.80.0-0.40.40.5-0.90.60.80.6
Latency to leave start box in cocaine runway0.30.51.7-0.20.5-0.4-0.51.3-0.7-0.90.1
Latency to leave start box in cocaine runway, F0.40.51.30.00.3-0.5-0.61.1-0.7-1.00.4
Latency to leave start box in cocaine runway, M0.00.00.0-0.1-0.0-0.2-0.20.1-0.2-0.2-0.1
Std. dev. time between licks in bursts0.30.62.20.8-0.80.10.2-1.50.40.70.5
Total sessions with >9 infusions0.20.20.30.4-0.4-0.5-0.60.1-0.6-0.6-0.0
Short access day 1 total inactive lever presses0.71.42.2-1.51.51.31.21.11.10.8-1.0
Short access day 10 total inactive lever presses0.00.00.00.20.1-0.1-0.10.1-0.1-0.2-0.0
Short access day 1 total infusions0.30.51.2-1.10.90.70.61.00.50.2-0.4
Short access day 10 total infusions0.50.92.20.30.3-0.8-0.91.5-1.1-1.40.5
Short access total infusions0.20.30.60.00.0-0.5-0.60.8-0.6-0.80.1
Short access day 1 locomotion0.40.71.4-0.91.20.70.61.10.50.2-1.1
Short access day 10 total locomotion0.10.41.6-0.80.90.10.11.3-0.1-0.4-0.5
Short access total locomotion0.40.61.7-0.91.10.40.31.30.2-0.1-0.9
One hour access (0.3 mA shock)2.93.56.5-2.62.31.71.62.11.40.8-1.8
Compulsive drug intake1.32.05.61.7-2.1-1.0-0.9-2.4-0.6-0.00.9
One hour access (shock baseline)2.25.710.0-3.23.12.32.22.71.91.2-1.9
Social response proportion0.60.81.31.1-0.5-1.1-1.10.2-1.1-1.1-0.4
Social responses0.30.41.41.2-0.7-0.4-0.3-0.6-0.3-0.1-0.8
Social time0.30.51.31.1-0.9-0.8-0.8-0.4-0.7-0.50.1
Soleus weight4.011.816.0-3.93.54.03.91.33.83.3-3.0
Bone: stiffness1.52.84.81.5-0.8-2.0-2.00.6-2.1-2.21.4
Tibialis anterior weight5.117.736.35.6-6.0-2.8-2.5-6.0-1.9-0.44.5
Time to tail flick, vehicle, before self-admin1.41.74.50.5-0.3-1.3-1.31.0-1.4-1.62.1
Time to tail flick, vehicle, after self-admin1.32.64.11.7-1.2-2.0-2.00.1-2.0-2.00.5
Time to tail flick, test, before self-admin0.80.93.4-0.41.0-0.4-0.51.9-0.7-1.0-1.0
Time to tail flick, test, after self-admin0.10.10.6-0.30.10.10.10.00.10.20.8
Delta time to tail flick, vehicle, before/after SA0.91.01.91.4-0.8-1.0-1.0-0.4-1.0-0.8-1.2
Delta time to tail flick, test, before/after SA1.61.95.40.1-1.10.70.8-2.31.11.62.0
Tibia length0.30.72.30.2-0.60.60.7-1.50.81.10.4
Ambulatory time before self-admin0.10.50.90.20.1-0.7-0.70.9-0.8-1.00.2
Ambulatory time after self-admin0.30.51.9-1.01.00.20.11.4-0.1-0.4-0.7
Bone: tissue strength0.10.10.4-0.20.5-0.0-0.00.6-0.1-0.3-0.6
Total heroin consumption3.23.75.62.3-2.4-1.9-1.9-1.7-1.6-1.22.2
Bone: trabecular number1.63.16.50.9-0.4-2.2-2.21.2-2.4-2.50.6
Bone: trabecular spacing0.60.91.7-0.30.31.21.2-0.51.31.3-0.4
Bone: trabecular thickness0.60.82.5-0.50.7-0.6-0.71.6-0.9-1.2-0.3
Bone: trabecular tissue density4.98.612.2-3.32.93.53.51.03.33.0-2.1
Water consumed over 24 hours0.71.31.81.0-1.0-1.3-1.3-0.2-1.3-1.21.3
Number of responses in last shaping day0.10.10.20.5-0.3-0.0-0.0-0.50.00.1-0.5