Hub : Genes

Ndufs8

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression Ndufs8 0.16 0.11 2.7e-05 0.1 0.09 0.1 0.09 8.6e-06 2.6e-05 6.9e-06 1.4e-05
2 OFC intron excision ratio chr1_210572763_210573418 0.16 0.12 9.0e-03 0.07 0.03 0.07 0.09 9.1e-03 7.5e-02 1.0e-02 4.5e-03
3 IC gene expression Ndufs8 0.12 0.09 2.7e-03 0.01 0.03 0.02 0.01 1.3e-01 1.5e-02 5.7e-02 7.6e-02
4 NAcc gene expression Ndufs8 0.06 0.04 4.0e-07 0.03 0.05 0.04 0.04 8.1e-05 9.4e-08 2.0e-07 1.9e-07
5 OFC intron excision ratio chr1_210572763_210573661 0.15 0.11 7.2e-03 0.08 -0.01 0.08 -0.01 5.1e-03 4.7e-01 7.5e-03 8.6e-01
6 pVTA gene expression Ndufs8 0.07 0.05 1.0e-04 0.03 0.05 0.05 0.04 2.4e-03 8.0e-05 1.0e-04 1.7e-04
7 Brain gene expression Ndufs8 0.06 0.04 1.1e-04 0.04 0.04 0.03 0.04 1.6e-04 1.6e-04 4.8e-04 3.3e-04
8 PL gene expression Ndufs8 0.03 0.03 3.2e-03 0.01 0.02 0.02 0.01 3.1e-02 2.0e-03 1.3e-03 1.0e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density1.83.16.8-0.8-0.3-2.2-2.2-1.5-2.4-2.6-0.4
Area under the delay curve0.50.61.0-0.50.1-0.7-0.8-0.8-0.8-1.0-1.0
BMI with tail2.38.012.7-3.2-1.9-3.4-3.5-0.5-3.6-3.6-0.9
BMI without tail1.54.56.4-2.4-1.9-2.5-2.50.6-2.5-2.3-1.5
Body weight2.410.617.5-4.2-3.6-3.7-3.61.8-3.4-2.9-2.1
Weight adjusted by age0.60.91.6-1.1-1.3-0.8-0.71.1-0.6-0.3-1.1
Bone surface3.66.510.8-2.3-1.6-3.2-3.2-0.5-3.3-3.2-1.4
Bone volume1.62.95.9-1.1-0.5-2.1-2.2-1.1-2.3-2.4-0.7
Breakpoint value in progressive ratio session1.92.33.5-1.9-1.7-1.6-1.51.1-1.4-1.1-1.6
Number of licking bursts0.10.10.3-0.10.2-0.3-0.3-0.3-0.3-0.3-0.6
Context. condit. distance diff. score0.70.91.81.21.30.70.7-1.20.60.31.0
Locomotion velocity, session 10.00.00.0-0.20.1-0.00.0-0.0-0.0-0.00.2
Locomotion distance, session 11.11.42.9-1.1-0.3-1.4-1.5-0.6-1.6-1.7-0.6
Locomotion velocity, session 21.82.03.6-1.9-1.7-1.4-1.31.3-1.2-0.9-1.5
Locomotion distance, session 21.01.42.4-1.6-1.0-1.4-1.40.3-1.4-1.3-0.6
Locomotion velocity, session 30.80.92.0-0.50.2-1.0-1.0-1.1-1.2-1.40.2
Locomotion distance, session 30.10.10.4-0.20.2-0.2-0.3-0.3-0.3-0.40.6
Stereotopy head waving bouts, day 30.50.61.90.30.6-0.5-0.6-1.4-0.8-1.00.1
Stereotopy head waving duration, day 30.50.52.01.01.00.20.1-1.4-0.0-0.30.3
Locomotion velocity, session 70.50.51.2-0.20.1-0.8-0.8-0.8-0.9-1.10.2
Locomotion distance, session 70.30.40.6-0.8-0.5-0.8-0.80.2-0.8-0.70.0
Stereotopy head waving bouts, day 70.60.72.20.30.6-0.6-0.7-1.5-0.8-1.10.3
Stereotopy head waving duration, day 71.21.52.8-0.7-0.5-1.5-1.5-0.8-1.6-1.7-0.6
Locomotion velocity, session 81.11.32.0-1.4-1.3-1.2-1.20.8-1.1-0.8-1.3
Locomotion distance, session 80.20.30.90.30.80.10.1-1.0-0.1-0.30.7
Degree of sensitization distance0.50.50.8-0.7-0.5-0.9-0.9-0.0-0.9-0.9-0.4
Degree of sensitization stereotypy0.50.51.1-0.4-0.2-0.9-0.9-0.6-1.0-1.0-0.1
Conditioned locomotion1.31.55.4-1.4-1.8-0.3-0.22.30.00.6-1.0
Cocaine response after cond. corrected0.00.10.10.30.40.10.1-0.40.1-0.00.3
Cocaine response after cond. not corrected0.10.10.50.20.4-0.1-0.2-0.7-0.2-0.40.3
Cocaine response before conditioning0.10.10.2-0.1-0.1-0.4-0.4-0.3-0.4-0.5-0.3
Saline control response2.53.45.4-2.0-2.1-1.9-1.81.3-1.7-1.3-2.3
Bone: connectivity density3.86.010.3-1.9-1.4-3.1-3.1-0.7-3.2-3.2-1.4
Bone: cortical apparent density0.20.21.0-0.6-0.7-0.1-0.01.00.10.3-0.0
Bone: cortical area0.30.51.5-0.8-0.9-0.2-0.11.20.00.3-0.8
Bone: cortical porosity0.10.10.2-0.4-0.1-0.3-0.3-0.1-0.3-0.3-0.4
Bone: cortical porosity0.30.40.8-0.8-0.6-0.5-0.50.3-0.5-0.4-0.9
Bone: cortical thickness2.44.011.1-2.6-2.9-1.0-0.83.3-0.40.4-2.1
Bone: cortical thickness1.21.42.7-1.4-1.7-0.8-0.71.6-0.5-0.1-1.5
Bone: cortical tissue density0.30.31.3-0.8-0.9-0.2-0.21.1-0.00.2-0.2
Condit. Reinf. active minus inactive responses0.30.30.6-0.4-0.0-0.7-0.7-0.4-0.7-0.80.3
Condit. Reinf. active-inactive response ratio0.10.10.30.10.2-0.3-0.3-0.5-0.4-0.50.5
Condit. Reinf. active responses0.00.00.2-0.10.1-0.2-0.2-0.1-0.2-0.20.4
Condit. Reinf. inactive responses0.10.10.20.40.30.40.40.10.40.40.4
Incentive salience index mean0.20.30.5-0.5-0.0-0.6-0.6-0.2-0.7-0.70.2
Condit. Reinf. lever presses0.00.00.1-0.10.1-0.00.00.20.00.1-0.0
Condit. Reinf. active minus inactive responses0.60.82.10.31.0-0.2-0.3-1.5-0.5-0.81.4
Condit. Reinf. active-inactive response ratio1.31.54.01.11.70.70.7-1.60.4-0.02.0
Condit. Reinf. active responses0.70.92.1-0.40.4-0.9-1.0-1.3-1.2-1.40.5
Condit. Reinf. inactive responses1.41.82.7-1.2-1.0-1.6-1.6-0.1-1.6-1.6-1.2
Condit. Reinf. lever presses1.01.42.5-1.2-0.6-1.5-1.5-0.5-1.6-1.6-0.3
Condit. Reinf. lever reinforcers received0.91.22.6-0.60.1-1.2-1.3-1.2-1.4-1.60.3
Conditioned reinforcement - actives0.50.91.50.70.31.11.10.41.11.21.1
Conditioned reinforcement - inactives1.92.84.62.12.11.61.5-1.81.30.81.7
Conditioned locomotion7.810.112.93.63.53.53.4-2.13.22.63.3
Patch foraging indifference point 0 sec0.10.30.70.90.60.40.4-0.70.30.2-0.0
Patch foraging indifference point AUC0.50.72.2-1.4-0.9-0.3-0.21.5-0.10.2-0.5
Delay disc. indifference point, 0s delay0.91.02.1-0.50.2-1.0-1.0-1.4-1.2-1.5-0.0
Delay disc. indifference point, 16s delay0.60.61.41.01.20.80.7-1.00.60.30.1
Delay disc. indifference point, 2s delay0.30.31.60.30.80.0-0.0-1.3-0.2-0.4-0.2
Delay disc. indifference point, 24s delay0.30.31.2-0.3-0.40.10.10.80.20.4-1.1
Delay disc. indifference point, 4s delay0.30.40.6-0.8-0.1-0.6-0.6-0.5-0.7-0.8-0.3
Delay disc. indifference point, 8s delay0.40.51.7-0.4-0.2-0.6-0.7-0.3-0.7-0.7-1.3
Indifference point function ln k2.74.79.33.12.42.32.2-1.72.01.51.8
Indifference point function log k2.74.79.33.12.42.32.2-1.72.01.51.8
Patch foraging total patch changes 0 sec0.10.20.50.70.20.40.4-0.10.50.5-0.3
Patch foraging total patch changes 12 sec1.92.54.4-2.1-1.8-1.5-1.51.4-1.3-0.9-1.8
Patch foraging total patch changes 18 sec0.30.41.0-0.8-0.5-0.6-0.70.2-0.6-0.5-1.0
Patch foraging total patch changes 24 sec0.50.82.6-1.0-1.0-0.5-0.41.2-0.30.0-1.6
Patch foraging total patch changes 6 sec1.11.72.9-1.5-1.0-1.4-1.50.3-1.4-1.3-1.7
Patch foraging time to switch 0 sec1.94.06.5-1.5-1.1-2.4-2.4-0.7-2.5-2.5-1.8
Patch foraging water rate 0 sec4.08.412.72.72.33.53.50.13.63.42.3
Patch foraging water rate 12 sec5.912.317.03.33.04.14.1-0.34.13.83.7
Patch foraging water rate 18 sec1.42.23.01.51.41.71.7-0.41.71.51.4
Patch foraging water rate 24 sec3.14.37.31.61.52.62.70.42.72.61.3
Patch foraging water rate 6 sec2.53.76.01.81.22.32.40.52.42.41.2
Seeking ratio, delayed vs. immediate footshock0.40.51.1-0.5-0.1-0.7-0.8-0.7-0.9-1.0-0.7
Distance traveled before self-admin0.20.30.6-0.2-0.0-0.6-0.7-0.6-0.7-0.8-0.4
Distance traveled after self-admin0.00.00.10.3-0.1-0.2-0.2-0.1-0.2-0.20.0
Extensor digitorum longus weight4.919.335.1-5.9-5.8-4.0-3.84.6-3.2-2.0-4.5
Bone: elastic displacement1.31.53.60.0-0.11.41.41.31.61.90.3
Bone: elastic work1.11.43.7-1.7-1.7-0.5-0.41.9-0.20.3-1.2
Bone: endosteal estimation0.81.75.01.52.00.50.4-2.20.1-0.41.3
Bone: endosteal perimeter1.73.710.62.22.80.70.6-3.30.2-0.62.2
Epididymis fat weight3.311.217.74.23.93.63.5-2.63.12.43.0
Delta time in closed arm before/after self-admin0.90.92.7-1.6-1.2-0.7-0.61.2-0.5-0.2-0.7
Delta time in open arm before/after self-admin0.10.10.30.20.1-0.3-0.3-0.4-0.4-0.5-0.5
Diff in mean of infusions in LGA sessions0.60.82.7-0.5-1.0-0.6-0.61.0-0.5-0.3-1.6
Delay discount exponential model param0.40.50.90.5-0.00.60.70.70.80.90.9
Extinction: sum of active levers before priming2.12.43.4-1.7-1.4-1.9-1.80.5-1.8-1.6-1.0
Active lever presses in extinction session 60.80.82.3-1.5-1.2-0.6-0.51.3-0.4-0.1-0.7
Bone: final force1.11.82.4-1.5-1.4-1.5-1.50.6-1.4-1.2-1.3
Bone: final moment1.01.72.4-1.6-1.4-1.4-1.40.7-1.3-1.1-1.2
Food consumed during 24 hour testing period0.40.50.80.80.70.90.9-0.10.90.80.4
Glucose1.42.27.21.51.90.20.1-2.7-0.2-0.91.9
Heart weight0.60.93.00.40.6-0.7-0.8-1.7-1.0-1.3-0.1
Delay discount hyperbolic model param0.40.50.80.5-0.10.60.70.80.70.90.8
Intermittent access intake day 1-15 change1.93.96.62.62.22.12.1-1.31.91.61.6
Intermittent access intake escalation1.73.55.92.42.02.12.0-1.11.91.61.5
Intermittent access intake escalation 22.32.63.82.01.81.71.7-1.11.61.21.7
Intermitt. access day 1 inactive lever presses0.00.00.0-0.10.00.10.10.00.10.10.1
Intermitt. access day 15 inactive lever presses0.51.02.91.31.40.70.6-1.70.4-0.00.5
Intermitt. access escalation Index2.43.44.62.01.92.12.1-0.72.01.81.6
Intermittent access day 1 total infusions0.91.57.20.91.4-0.0-0.2-2.7-0.5-1.1-0.0
Intermittent access day 15 total infusions3.14.78.73.02.92.11.9-2.81.60.91.4
Intermittent access terminal intake (last 3 days)2.43.28.02.42.51.41.2-2.80.90.31.0
Intermittent access total infusions1.41.75.71.61.90.80.6-2.40.4-0.20.6
Intermittent access day 1 locomotion0.50.63.00.61.10.1-0.0-1.7-0.2-0.60.4
Intermittent access day 15 total locomotion2.44.47.92.72.81.91.7-2.81.40.81.7
Intermittent access total locomotion4.45.211.12.83.21.91.7-3.31.40.51.9
Intermittent access standard deviation0.30.71.61.31.10.80.7-1.10.60.30.2
Left kidney weight0.73.35.32.12.31.81.8-1.81.51.11.9
Right kidney weight0.62.83.92.01.91.91.9-0.81.81.51.3
Cocaine induced anxiety0.10.10.30.10.3-0.2-0.1-0.5-0.2-0.30.5
Post-drug Anxiety0.30.40.6-0.5-0.6-0.8-0.70.2-0.7-0.6-0.3
Baseline Anxiety0.30.41.0-0.6-1.0-0.5-0.50.9-0.4-0.2-0.5
Tail length0.51.85.5-1.3-2.0-0.6-0.52.3-0.20.4-1.7
Length with tail1.35.812.3-3.0-3.5-2.0-1.83.2-1.4-0.6-2.3
Length without tail1.44.48.8-2.9-3.0-1.8-1.72.5-1.4-0.8-1.8
Times rat made contact with spout0.80.91.4-0.9-0.6-1.2-1.2-0.2-1.2-1.2-0.7
Lifetime Intake0.70.93.21.21.30.60.4-1.80.3-0.20.4
Liver weight, left0.60.91.51.10.61.21.20.11.21.2-0.0
Liver weight, right1.12.03.11.81.31.61.6-0.31.61.41.1
Locomotor activity0.91.52.01.21.11.41.4-0.21.41.31.2
Locomotor testing distance0.91.72.61.31.21.61.6-0.21.61.40.8
Locomotor testing rearing0.51.02.01.01.30.70.7-1.30.50.21.4
Locomotion in novel chamber4.15.210.43.22.92.22.1-2.61.81.11.7
Locomotion in novel chamber post-restriction2.43.96.02.42.51.91.8-1.91.61.12.2
Fecal boli incidents, locomotor time 10.00.10.10.00.30.30.3-0.20.30.2-0.2
Change in fecal boli incidents, locomotor task0.10.10.2-0.4-0.3-0.4-0.40.1-0.4-0.4-0.3
Time >=10cm from walls, locomotor time 11.31.44.70.91.50.20.0-2.2-0.2-0.71.5
Bouts of movement, locomotor time 10.50.51.9-1.1-0.9-0.2-0.11.40.10.4-0.3
Total resting periods, locomotor time 10.30.31.1-0.6-0.50.10.21.10.30.6-0.2
Rest time, locomotor task time 11.92.43.61.71.41.91.9-0.31.81.71.0
Distance moved, locomotor task time 10.60.91.7-0.8-0.2-1.0-1.1-0.8-1.2-1.3-1.0
Vertical activity count, locomotor time 10.20.41.40.81.00.30.2-1.20.1-0.3-0.0
Time >=10cm from walls, locomotor time 20.40.62.90.20.40.70.70.20.70.71.7
Bouts of movement, locomotor time 20.30.41.6-1.3-0.7-0.5-0.50.6-0.4-0.2-0.5
Total resting periods, locomotor time 20.10.20.9-0.9-0.4-0.4-0.40.1-0.3-0.3-0.3
Rest time, locomotor task time 21.01.33.11.61.60.80.7-1.80.50.10.7
Distance moved, locomotor task time 20.60.72.3-0.9-1.1-0.3-0.21.5-0.00.3-1.1
Vertical activity count, locomotor time 20.81.03.0-0.0-0.50.80.91.71.11.4-0.3
Light reinforcement 10.41.01.51.20.91.21.2-0.41.21.00.6
Light reinforcement 22.13.35.22.11.62.02.0-0.71.91.62.3
Bone: marrow area0.81.75.11.52.00.50.4-2.30.1-0.41.3
Bone: maximum diameter0.10.20.40.60.50.60.6-0.10.50.50.1
Bone: maximum force2.13.85.8-2.0-1.3-2.4-2.4-0.3-2.4-2.4-1.3
Bone: maximum moment2.03.45.2-2.0-1.3-2.2-2.2-0.2-2.3-2.2-1.1
Mean time between licks in bursts0.30.61.0-0.9-0.9-0.7-0.70.8-0.6-0.4-1.0
Mean num. licks in bursts0.10.10.2-0.3-0.3-0.3-0.3-0.1-0.3-0.40.4
Cd content in liver1.51.72.91.51.71.21.2-1.21.00.71.5
Co content in liver1.51.73.30.80.31.61.61.01.71.80.9
Cu content in liver0.00.00.10.20.10.30.20.10.30.20.3
Fe content in liver0.10.10.3-0.5-0.5-0.2-0.20.4-0.2-0.1-0.1
K content in liver0.60.60.9-0.8-0.6-0.9-0.9-0.0-0.9-0.9-0.3
Mg content in liver0.20.20.60.60.70.10.1-0.8-0.0-0.20.4
Mn content in liver1.71.93.2-1.8-1.6-1.4-1.41.2-1.2-0.9-1.3
Na content in liver0.30.40.80.3-0.00.60.70.70.80.9-0.0
Rb content in liver0.70.82.11.01.30.30.2-1.50.0-0.41.2
Se content in liver0.20.20.70.40.5-0.1-0.1-0.8-0.2-0.40.3
Sr content in liver1.21.12.6-1.2-1.5-0.5-0.41.6-0.20.2-1.3
Zn content in liver0.30.31.0-0.5-0.7-0.1-0.11.00.00.3-0.7
Bone: minimum diameter0.71.35.00.61.6-0.1-0.2-2.2-0.5-1.01.2
Time in familiar zone, hab. session 10.50.51.30.50.90.30.2-1.10.1-0.11.1
Time in novel zone, hab. session 10.20.20.8-0.0-0.4-0.0-0.00.50.00.1-0.9
Total zone transitions, hab. session 10.40.60.9-0.9-0.7-0.8-0.80.3-0.8-0.7-0.9
Total locomotion distance, hab. session 10.20.30.80.70.90.50.5-0.80.40.10.4
Locomotion velocity, hab. session 10.10.10.20.30.40.30.2-0.30.20.10.3
Time in familiar zone, hab. session 20.20.20.9-0.6-0.6-0.1-0.00.90.10.3-0.0
Time in novel zone, hab. session 20.40.40.90.00.1-0.6-0.6-0.9-0.7-1.0-0.3
Total zone transitions, hab. session 23.03.97.4-1.7-0.9-2.4-2.4-0.9-2.6-2.7-0.9
Total locomotion distance, hab. session 20.60.71.8-0.30.2-0.9-0.9-1.0-1.1-1.3-0.0
Locomotion velocity, hab. session 20.40.51.40.00.5-0.6-0.6-1.2-0.8-1.10.3
Novel to familiar place preference ratio0.40.50.9-0.2-0.3-0.7-0.8-0.2-0.8-0.9-0.9
Novelty place preference0.30.30.60.1-0.0-0.5-0.6-0.5-0.6-0.7-0.7
Time in novel zone, NPP test0.30.30.60.1-0.1-0.6-0.6-0.5-0.7-0.8-0.8
Total zone transitions, NPP test1.31.82.8-1.5-0.8-1.6-1.6-0.2-1.7-1.6-0.9
Total locomotion distance, NPP test0.10.20.4-0.30.3-0.3-0.3-0.6-0.4-0.60.3
Locomotion velocity, NPP test0.10.10.2-0.20.4-0.2-0.2-0.5-0.3-0.40.4
Intraocular pressure1.01.42.50.70.71.51.50.51.51.60.8
Delta distance traveled before/after self-admin0.10.10.30.3-0.10.20.30.60.30.40.3
Delta ambulatory time before/after self-admin0.10.10.70.1-0.30.20.20.80.30.40.1
Parametrial fat weight1.94.58.02.62.81.81.7-2.71.30.72.5
Pavlov. Cond. lever latency0.20.30.50.50.40.70.7-0.10.70.60.4
Pavlov. Cond. magazine entry latency0.40.51.40.20.7-0.5-0.6-1.2-0.7-0.90.1
Pavlov. Cond. change in total contacts0.40.41.30.80.90.10.1-1.2-0.1-0.30.8
Pavlov. Cond. index score0.10.10.30.40.60.10.1-0.40.0-0.00.3
Pavlov. Cond. latency score0.10.10.20.20.4-0.2-0.2-0.5-0.2-0.30.1
Pavlov. Cond. lever contacts0.10.10.1-0.10.1-0.4-0.4-0.2-0.4-0.40.0
Pavlov. Cond. magazine entry number0.10.10.4-0.6-0.6-0.2-0.20.4-0.2-0.2-0.2
Pavlov. Cond. intertrial magazine entries0.50.61.10.50.10.90.90.51.01.10.3
Pavlov. Cond. lever-magazine prob. diff.0.10.10.30.30.5-0.0-0.0-0.4-0.0-0.10.4
Pavlov. Cond. response bias0.10.10.30.60.50.30.2-0.20.20.20.2
Pavlov. Cond. lever latency0.00.00.00.00.00.00.00.00.0-0.00.1
Pavlov. Cond. magazine entry latency3.74.56.5-2.3-1.7-2.5-2.50.4-2.5-2.3-1.8
Pavlov. Cond. change in total contacts0.40.71.4-0.5-0.2-1.0-1.0-0.7-1.1-1.2-0.5
Pavlov. Cond. index score0.91.31.9-1.1-0.8-1.4-1.4-0.1-1.4-1.3-0.9
Pavlov. Cond. latency score0.70.91.4-0.9-0.6-1.2-1.2-0.1-1.2-1.1-0.8
Pavlov. Cond. lever contacts0.00.00.0-0.1-0.0-0.2-0.2-0.1-0.2-0.2-0.2
Pavlov. Cond. magazine entry number4.35.47.72.52.02.82.7-0.52.72.51.8
Pavlov. Cond. intertrial magazine entries1.11.72.81.71.31.51.5-0.61.41.21.0
Pavlov. Cond. lever-magazine prob. diff.1.21.62.5-1.3-1.0-1.6-1.60.0-1.6-1.5-1.0
Pavlov. Cond. response bias1.01.32.0-1.2-0.8-1.4-1.4-0.1-1.4-1.4-0.9
Time in closed arm before self-admin0.40.61.71.11.00.40.3-1.30.1-0.20.6
Time in closed arm after self-admin0.10.10.2-0.00.20.30.30.00.30.30.5
Time in open arm before self-admin0.40.41.3-0.7-0.9-0.3-0.21.1-0.10.3-0.8
Time in open arm after self-admin0.70.71.9-0.6-0.8-0.9-0.90.4-0.8-0.7-1.4
Bone: periosteal estimation0.10.10.40.40.60.20.2-0.60.1-0.00.2
Bone: periosteal perimeter0.20.31.10.20.6-0.3-0.3-1.0-0.4-0.70.3
Bone: post-yield work3.14.610.4-0.40.9-2.0-2.2-3.1-2.6-3.20.3
Progressive ratio test 1 active lever presses0.10.10.3-0.10.10.30.20.10.30.30.6
Progressive ratio test 1 breakpoint0.10.10.2-0.10.10.30.20.20.30.30.5
Progressive ratio test 1 inactive lever presses0.10.10.6-0.20.00.10.10.00.10.10.8
Progressive ratio test 2 active lever presses1.11.32.21.51.41.10.9-1.30.80.51.2
Progressive ratio test 2 breakpoint1.11.22.11.41.41.11.0-1.20.80.51.1
Progressive ratio test 2 inactive lever presses3.76.010.03.23.12.42.2-2.81.91.22.3
Incentive Sensitization - Responses0.20.30.70.00.0-0.6-0.6-0.8-0.7-0.80.1
Incentive Sensitization - Breakpoint0.20.30.90.20.2-0.4-0.4-1.0-0.5-0.70.3
Sum of active levers in priming session hrs 5-61.81.73.80.3-0.21.41.51.71.62.00.3
Progressive ratio2.54.07.9-1.3-0.7-2.4-2.5-1.2-2.6-2.8-1.0
Food seeking constrained by brief footshock0.30.31.0-0.2-0.4-0.6-0.6-0.0-0.6-0.6-1.0
Seeking ratio, punishment vs. effort1.72.54.71.30.82.02.00.72.12.20.4
Retroperitoneal fat weight6.025.744.76.76.15.14.9-4.54.43.24.9
Reaction time number correct0.20.31.2-0.7-0.5-0.00.11.10.20.50.6
Reaction time mean minus median1.12.85.6-2.4-1.5-2.0-1.90.5-1.9-1.6-0.7
Reaction time mean minus median AUC0.71.74.4-2.1-1.4-1.4-1.31.0-1.2-0.9-0.4
Reaction time num false alarms0.30.40.90.0-0.30.50.61.00.70.9-0.3
Reaction time num false alarms AUC0.30.51.6-0.7-1.0-0.2-0.11.30.00.3-1.0
Reaction time trials correct on left0.20.31.2-0.7-0.5-0.00.11.10.20.50.6
Reaction time trials on left0.20.41.5-0.8-0.7-0.10.01.20.20.50.5
Reaction time mean0.10.20.5-0.10.1-0.5-0.6-0.5-0.6-0.7-0.1
Reaction time mean AUC0.10.20.6-0.00.2-0.5-0.5-0.7-0.6-0.70.1
Median of all reaction times0.20.20.80.50.5-0.2-0.3-0.9-0.4-0.60.0
Reaction time omissions1.62.34.5-2.1-1.8-1.7-1.61.2-1.5-1.1-0.7
Reaction time false alarm rate0.20.20.9-0.1-0.50.10.10.70.20.4-0.9
Reaction time premature initiation rate2.12.94.6-2.1-2.0-1.8-1.71.6-1.5-1.1-1.5
Reaction time premature initiations2.03.56.9-2.6-2.5-1.7-1.62.4-1.3-0.8-1.3
Std. dev. reaction times0.51.01.8-1.3-0.8-1.2-1.20.1-1.2-1.1-0.4
Reaction time trials completed0.20.41.5-0.8-0.7-0.10.01.20.20.50.5
Reaction time trials AUC0.20.31.1-0.7-0.5-0.00.01.00.10.40.5
Run reversals in cocaine runway, females1.31.32.0-1.3-0.8-1.4-1.4-0.2-1.4-1.4-0.3
Run reversals in cocaine runway, males0.30.30.8-0.0-0.40.40.50.90.60.8-0.6
Latency to leave start box in cocaine runway0.40.51.70.20.5-0.4-0.5-1.3-0.7-0.9-0.1
Latency to leave start box in cocaine runway, F0.40.51.3-0.00.3-0.5-0.6-1.1-0.7-1.0-0.4
Latency to leave start box in cocaine runway, M0.00.00.00.1-0.0-0.2-0.2-0.1-0.2-0.20.1
Std. dev. time between licks in bursts0.40.62.2-0.8-0.80.10.21.50.40.7-0.5
Total sessions with >9 infusions0.20.20.3-0.4-0.4-0.5-0.6-0.1-0.6-0.6-0.0
Short access day 1 total inactive lever presses1.11.42.21.51.51.31.2-1.11.10.81.0
Short access day 10 total inactive lever presses0.00.00.0-0.20.1-0.1-0.1-0.1-0.1-0.20.0
Short access day 1 total infusions0.40.51.21.10.90.70.6-1.00.50.20.3
Short access day 10 total infusions0.70.92.2-0.30.3-0.8-0.9-1.5-1.1-1.4-0.6
Short access total infusions0.20.30.6-0.00.0-0.5-0.6-0.8-0.6-0.8-0.2
Short access day 1 locomotion0.60.71.40.91.20.70.6-1.10.50.21.1
Short access day 10 total locomotion0.20.41.60.80.90.10.1-1.3-0.1-0.40.5
Short access total locomotion0.50.61.70.91.10.40.3-1.30.2-0.10.9
One hour access (0.3 mA shock)3.03.56.52.62.31.71.6-2.11.40.81.8
Compulsive drug intake1.72.05.6-1.7-2.1-1.0-0.92.4-0.6-0.0-0.9
One hour access (shock baseline)3.75.710.03.23.12.32.2-2.71.91.21.9
Social response proportion0.70.81.3-1.1-0.5-1.1-1.1-0.2-1.1-1.10.4
Social responses0.30.41.4-1.2-0.7-0.4-0.30.6-0.3-0.10.8
Social time0.40.51.3-1.1-0.9-0.8-0.80.4-0.7-0.5-0.1
Soleus weight4.011.816.03.93.54.03.9-1.33.83.33.0
Bone: stiffness1.72.84.8-1.5-0.8-2.0-2.0-0.6-2.1-2.2-1.4
Tibialis anterior weight5.217.636.3-5.6-6.0-2.8-2.56.0-1.9-0.4-4.5
Time to tail flick, vehicle, before self-admin1.71.74.6-0.5-0.3-1.3-1.3-1.0-1.4-1.6-2.1
Time to tail flick, vehicle, after self-admin2.02.64.1-1.7-1.2-2.0-2.0-0.1-2.0-2.0-0.5
Time to tail flick, test, before self-admin0.90.93.40.41.0-0.4-0.5-1.9-0.7-1.01.0
Time to tail flick, test, after self-admin0.10.10.60.30.10.10.1-0.00.10.2-0.8
Delta time to tail flick, vehicle, before/after SA1.01.01.9-1.4-0.8-1.0-1.00.4-1.0-0.81.2
Delta time to tail flick, test, before/after SA1.91.95.4-0.1-1.10.70.82.31.11.6-2.0
Tibia length0.30.72.3-0.2-0.60.60.71.50.81.1-0.3
Ambulatory time before self-admin0.30.50.9-0.20.1-0.7-0.7-0.9-0.8-1.0-0.3
Ambulatory time after self-admin0.50.51.91.01.00.20.1-1.4-0.1-0.40.7
Bone: tissue strength0.10.10.40.20.5-0.0-0.0-0.6-0.1-0.30.6
Total heroin consumption3.23.75.6-2.3-2.4-1.9-1.91.7-1.6-1.2-2.2
Bone: trabecular number1.83.16.5-0.9-0.4-2.2-2.2-1.2-2.4-2.5-0.6
Bone: trabecular spacing0.60.91.70.30.31.21.20.51.31.30.4
Bone: trabecular thickness0.60.82.50.50.7-0.6-0.7-1.6-0.9-1.20.3
Bone: trabecular tissue density5.88.612.23.32.93.53.5-1.03.33.02.1
Water consumed over 24 hours1.01.31.8-1.0-1.0-1.3-1.30.2-1.3-1.2-1.3
Number of responses in last shaping day0.10.10.2-0.5-0.3-0.0-0.00.50.00.10.5