Hub : Genes

Ndufs8

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	gene expression	Ndufs8	0.17	0.11	3.1e-06	0.1	0.1	0.09	0.1	5.8e-06	9.5e-06	1.2e-05	4.3e-06
2	PL	gene expression	Ndufs8	0.03	0.02	6.7e-03	0.01	0.01	0.01	0.01	4.5e-02	8.5e-03	3.3e-02	2.7e-02
3	NAcc	gene expression	Ndufs8	0.02	0.02	9.1e-03	0	0	0	0	2.7e-01	7.7e-02	2.6e-01	2.0e-01
4	Liver	isoform ratio	NM_001106322.2	0.09	0.05	1.0e-06	0.05	0.05	0.05	0.05	4.4e-06	2.0e-06	2.4e-06	1.9e-06
5	NAcc	alternative TSS	NM_001106322.2	0.02	0.02	9.1e-03	0.02	0.02	0.02	0.01	5.6e-03	5.6e-03	8.6e-04	1.1e-02
6	Brain	gene expression	Ndufs8	0.06	0.05	1.2e-04	0.04	0.04	0.02	0.03	2.3e-04	2.9e-04	2.9e-03	1.0e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	1.9	3.1	6.1	-0.4	-1.8	-2.0	1.6	1.6	2.5
Area under the delay curve	0.6	0.6	1.4	0.0	-0.5	-0.7	1.2	0.6	1.1
BMI with tail	4.0	12.8	17.1	-2.7	-3.7	-3.7	4.1	3.6	3.5
BMI without tail	2.2	4.5	5.6	-1.6	-2.3	-2.4	2.3	2.0	2.0
Body weight	2.9	12.3	15.7	-3.9	-4.0	-3.7	3.6	3.3	2.2
Weight adjusted by age	1.2	1.4	3.1	-1.8	-1.2	-1.1	0.9	1.2	0.6
Bone surface	4.0	7.0	8.9	-1.9	-2.9	-3.0	2.7	2.5	2.9
Bone volume	1.8	3.1	5.2	-0.7	-1.8	-2.0	1.8	1.6	2.3
Breakpoint value in progressive ratio session	1.7	1.8	3.2	-1.8	-1.6	-1.5	1.1	1.2	0.7
Number of licking bursts	0.1	0.1	0.2	-0.2	-0.3	-0.3	0.1	0.2	0.4
Context. condit. distance diff. score	0.4	0.5	1.3	1.2	0.8	0.7	-0.4	-0.6	-0.1
Locomotion velocity, session 1	0.0	0.0	0.0	-0.1	-0.0	-0.1	-0.1	0.1	0.0
Locomotion distance, session 1	1.6	2.0	3.1	-0.9	-1.4	-1.5	1.5	1.4	1.8
Locomotion velocity, session 2	1.5	1.8	3.3	-1.8	-1.5	-1.4	1.1	1.2	0.6
Locomotion distance, session 2	1.3	1.8	2.2	-1.5	-1.4	-1.4	1.3	1.3	1.2
Locomotion velocity, session 3	1.0	1.1	2.3	0.1	-0.9	-1.1	1.2	1.0	1.5
Locomotion distance, session 3	0.1	0.1	0.2	-0.0	-0.2	-0.3	0.3	0.3	0.4
Stereotopy head waving bouts, day 3	0.5	0.5	1.4	0.7	-0.4	-0.6	0.8	0.5	1.2
Stereotopy head waving duration, day 3	0.2	0.3	1.3	1.1	0.4	0.2	0.0	-0.2	0.5
Locomotion velocity, session 7	0.7	0.7	1.5	-0.1	-0.7	-0.8	1.0	0.9	1.2
Locomotion distance, session 7	0.4	0.5	0.7	-0.8	-0.7	-0.7	0.5	0.6	0.6
Stereotopy head waving bouts, day 7	0.4	0.5	1.0	1.0	-0.1	-0.3	0.8	0.4	1.0
Stereotopy head waving duration, day 7	2.1	2.5	3.9	-0.5	-1.6	-1.7	2.0	1.5	1.8
Locomotion velocity, session 8	1.0	1.2	1.8	-1.3	-1.3	-1.2	1.0	1.0	0.5
Locomotion distance, session 8	0.0	0.0	0.2	0.3	0.1	-0.0	0.1	0.1	0.4
Degree of sensitization distance	0.5	0.5	0.6	-0.7	-0.7	-0.8	0.7	0.7	0.8
Degree of sensitization stereotypy	0.8	0.8	1.5	-0.2	-0.9	-0.9	1.2	0.9	1.1
Conditioned locomotion	0.6	0.8	3.1	-1.8	-0.5	-0.2	-0.2	0.1	-1.0
Cocaine response after cond. corrected	0.1	0.1	0.2	0.5	0.2	0.2	-0.2	-0.2	0.0
Cocaine response after cond. not corrected	0.1	0.1	0.3	0.4	-0.0	-0.1	0.3	0.2	0.5
Cocaine response before conditioning	0.2	0.3	0.4	-0.4	-0.4	-0.5	0.7	0.5	0.6
Saline control response	2.1	2.7	4.3	-2.1	-1.9	-1.8	1.5	1.4	0.9
Bone: connectivity density	4.1	6.5	8.8	-1.7	-2.8	-3.0	2.4	2.3	2.9
Bone: cortical apparent density	0.3	0.4	1.4	-1.2	-0.6	-0.5	0.5	0.5	-0.0
Bone: cortical area	0.1	0.2	0.6	-0.8	-0.2	-0.1	-0.2	-0.1	-0.6
Bone: cortical porosity	0.1	0.1	0.2	0.3	-0.2	-0.2	0.4	0.2	0.3
Bone: cortical porosity	0.2	0.3	0.4	-0.4	-0.6	-0.5	0.7	0.5	0.3
Bone: cortical thickness	1.1	1.8	7.5	-2.7	-1.3	-0.9	0.2	0.4	-1.0
Bone: cortical thickness	0.7	0.9	3.4	-1.9	-1.0	-0.7	0.1	0.4	-0.3
Bone: cortical tissue density	0.4	0.5	1.6	-1.3	-0.7	-0.6	0.5	0.5	-0.0
Condit. Reinf. active minus inactive responses	0.4	0.5	0.7	-0.2	-0.6	-0.7	0.9	0.7	0.9
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.3	0.2	-0.2	-0.3	0.5	0.4	0.5
Condit. Reinf. active responses	0.0	0.1	0.1	-0.0	-0.1	-0.2	0.4	0.3	0.3
Condit. Reinf. inactive responses	0.1	0.1	0.1	0.2	0.3	0.3	-0.2	-0.2	-0.3
Incentive salience index mean	0.4	0.4	0.6	-0.5	-0.6	-0.6	0.8	0.7	0.8
Condit. Reinf. lever presses	0.0	0.1	0.3	-0.6	0.0	0.0	-0.0	0.1	-0.1
Condit. Reinf. active minus inactive responses	0.3	0.4	1.2	1.0	0.0	-0.2	0.5	0.3	1.1
Condit. Reinf. active-inactive response ratio	0.7	0.7	2.8	1.7	0.9	0.7	-0.4	-0.5	0.3
Condit. Reinf. active responses	0.8	1.1	2.7	0.3	-0.7	-0.9	1.2	1.0	1.6
Condit. Reinf. inactive responses	1.7	2.1	2.6	-1.0	-1.5	-1.6	1.6	1.4	1.5
Condit. Reinf. lever presses	1.3	1.7	2.1	-1.0	-1.4	-1.5	1.4	1.2	1.4
Condit. Reinf. lever reinforcers received	1.0	1.4	3.1	0.0	-1.0	-1.2	1.4	1.1	1.8
Conditioned reinforcement - actives	0.7	0.7	0.9	0.5	0.9	1.0	-0.8	-0.9	-0.7
Conditioned reinforcement - inactives	4.1	4.6	6.9	2.6	2.5	2.4	-1.8	-2.1	-0.9
Conditioned locomotion	9.0	10.8	14.7	3.4	3.8	3.7	-3.2	-2.9	-2.4
Patch foraging indifference point 0 sec	0.2	0.3	1.4	1.2	0.6	0.5	0.0	-0.3	-0.1
Patch foraging indifference point AUC	0.7	0.8	2.6	-1.6	-0.8	-0.6	0.9	0.7	-0.1
Delay disc. indifference point, 0s delay	0.9	1.0	2.4	0.1	-0.8	-1.0	1.6	0.7	1.3
Delay disc. indifference point, 16s delay	0.5	0.5	1.4	1.2	0.9	0.8	-0.2	-0.4	-0.2
Delay disc. indifference point, 2s delay	0.1	0.1	0.3	0.3	0.1	-0.1	0.4	0.1	0.6
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	-0.0	0.1	0.1	-0.2	-0.3	-0.5
Delay disc. indifference point, 4s delay	0.4	0.5	1.1	-0.3	-0.4	-0.5	1.0	0.7	0.8
Delay disc. indifference point, 8s delay	0.4	0.4	0.9	-0.1	-0.6	-0.7	1.0	0.5	0.8
Indifference point function ln k	3.5	4.9	7.7	2.8	2.4	2.2	-2.4	-2.0	-1.1
Indifference point function log k	3.5	4.9	7.7	2.8	2.4	2.2	-2.4	-2.0	-1.1
Patch foraging total patch changes 0 sec	0.2	0.3	0.8	0.9	0.5	0.6	-0.2	-0.4	-0.5
Patch foraging total patch changes 12 sec	1.7	2.2	3.3	-1.8	-1.6	-1.5	1.8	1.3	0.6
Patch foraging total patch changes 18 sec	0.4	0.5	1.2	-0.6	-0.7	-0.7	1.1	0.7	0.3
Patch foraging total patch changes 24 sec	0.3	0.3	0.9	-0.9	-0.7	-0.5	0.5	0.3	-0.3
Patch foraging total patch changes 6 sec	1.2	1.7	3.0	-0.7	-1.4	-1.4	1.7	1.3	1.1
Patch foraging time to switch 0 sec	3.2	5.0	6.1	-1.6	-2.3	-2.5	2.4	2.1	2.5
Patch foraging water rate 0 sec	6.7	10.7	13.1	2.7	3.5	3.6	-3.3	-3.1	-3.3
Patch foraging water rate 12 sec	9.2	14.1	16.8	3.1	4.1	4.1	-4.0	-3.6	-3.5
Patch foraging water rate 18 sec	1.9	2.6	3.3	1.5	1.8	1.8	-1.7	-1.6	-1.2
Patch foraging water rate 24 sec	4.2	5.9	7.0	1.8	2.5	2.6	-2.7	-2.3	-2.6
Patch foraging water rate 6 sec	3.2	4.6	6.2	1.3	2.2	2.3	-2.5	-2.2	-2.3
Seeking ratio, delayed vs. immediate footshock	0.5	0.6	1.0	-0.1	-0.8	-0.9	0.8	0.8	1.0
Distance traveled before self-admin	0.1	0.1	0.2	-0.4	-0.5	-0.5	0.1	0.2	0.3
Distance traveled after self-admin	0.1	0.1	0.2	0.0	-0.1	-0.2	-0.5	0.3	0.2
Extensor digitorum longus weight	3.7	14.6	32.1	-5.7	-4.3	-3.8	3.3	3.2	1.3
Bone: elastic displacement	2.1	2.4	4.7	0.4	1.4	1.6	-1.6	-1.5	-2.2
Bone: elastic work	0.3	0.4	1.5	-1.2	-0.5	-0.2	-0.0	0.0	-0.9
Bone: endosteal estimation	0.4	0.8	3.4	1.8	0.8	0.5	0.1	-0.2	0.8
Bone: endosteal perimeter	0.8	1.8	7.4	2.7	1.2	0.7	-0.0	-0.4	1.1
Epididymis fat weight	1.9	4.5	8.1	2.8	2.6	2.4	-1.7	-1.7	-1.0
Delta time in closed arm before/after self-admin	0.3	0.3	1.1	-1.0	-0.5	-0.4	0.5	-0.2	-0.1
Delta time in open arm before/after self-admin	0.0	0.0	0.1	0.3	0.3	0.2	-0.2	0.1	0.1
Diff in mean of infusions in LGA sessions	0.2	0.2	0.7	-0.8	-0.5	-0.4	0.1	-0.0	-0.3
Delay discount exponential model param	0.5	0.5	1.1	0.1	0.5	0.6	-1.0	-0.5	-1.0
Extinction: sum of active levers before priming	3.8	3.8	5.1	-2.2	-2.3	-2.2	1.6	2.0	1.3
Active lever presses in extinction session 6	0.3	0.3	1.2	-1.1	-0.3	-0.1	-0.1	-0.0	-0.6
Bone: final force	1.4	2.2	3.3	-1.8	-1.8	-1.7	1.3	1.2	1.0
Bone: final moment	1.1	1.9	2.8	-1.7	-1.6	-1.5	1.1	1.1	0.9
Food consumed during 24 hour testing period	0.6	0.7	0.9	0.7	0.8	0.8	-1.0	-0.9	-0.8
Glucose	0.4	0.5	1.8	1.4	0.6	0.3	0.2	0.0	0.9
Heart weight	0.7	0.9	2.5	1.6	1.1	1.0	-0.6	-0.7	-0.2
Delay discount hyperbolic model param	0.5	0.5	1.1	0.2	0.5	0.6	-1.1	-0.5	-1.1
Intermittent access intake day 1-15 change	2.3	2.2	3.0	1.5	1.6	1.6	-1.7	-1.5	-1.0
Intermittent access intake escalation	1.6	1.6	2.0	1.4	1.4	1.3	-1.4	-1.2	-0.6
Intermittent access intake escalation 2	1.0	0.9	1.6	0.9	1.1	1.1	-1.3	-0.8	-0.7
Intermitt. access day 1 inactive lever presses	0.8	0.8	2.0	1.4	1.1	1.0	-0.5	-0.3	-0.3
Intermitt. access day 15 inactive lever presses	0.9	0.9	2.7	1.6	1.1	0.9	-0.7	-0.7	0.0
Intermitt. access escalation Index	2.5	2.2	3.1	1.5	1.8	1.7	-1.3	-1.5	-1.2
Intermittent access day 1 total infusions	0.8	1.0	3.5	1.9	0.5	0.2	0.4	0.1	1.4
Intermittent access day 15 total infusions	3.5	3.9	9.8	3.1	2.3	2.0	-1.5	-1.6	-0.2
Intermittent access terminal intake (last 3 days)	1.9	2.0	6.4	2.5	1.6	1.3	-0.8	-1.0	0.2
Intermittent access total infusions	0.9	1.0	3.7	1.9	1.0	0.7	-0.1	-0.4	0.6
Intermittent access day 1 locomotion	0.8	0.8	2.0	0.9	-0.1	-0.3	1.1	0.9	1.4
Intermittent access day 15 total locomotion	2.0	2.2	4.7	2.2	1.8	1.5	-1.0	-1.3	-0.2
Intermittent access total locomotion	1.5	1.7	5.5	2.4	1.5	1.1	-0.3	-0.7	0.7
Intermittent access standard deviation	0.8	0.9	1.2	1.1	1.0	0.9	-0.9	-1.1	-0.4
Left kidney weight	1.2	3.3	4.2	2.0	2.0	2.0	-1.5	-1.6	-1.7
Right kidney weight	1.3	3.6	4.6	1.7	2.1	2.1	-1.7	-1.7	-2.0
Cocaine induced anxiety	0.1	0.1	0.3	0.2	0.2	0.1	-0.4	-0.6	-0.1
Post-drug Anxiety	0.2	0.3	0.9	-0.9	-0.6	-0.4	-0.1	-0.1	-0.3
Baseline Anxiety	0.7	0.8	2.1	-1.4	-1.0	-0.8	0.5	0.8	-0.0
Tail length	0.2	0.5	1.5	-1.2	-0.6	-0.3	-0.5	-0.1	-1.0
Length with tail	0.8	2.9	7.9	-2.8	-2.1	-1.7	1.1	1.2	-0.2
Length without tail	1.3	2.8	5.2	-2.3	-1.9	-1.7	1.6	1.6	0.4
Times rat made contact with spout	0.9	1.0	1.3	-0.5	-1.1	-1.2	1.0	0.9	1.1
Lifetime Intake	0.7	0.8	3.1	1.7	0.8	0.6	0.1	-0.2	0.7
Liver weight, left	0.2	0.3	0.6	0.4	0.4	0.4	-0.8	-0.6	-0.3
Liver weight, right	0.3	0.5	0.7	0.5	0.7	0.8	-0.8	-0.7	-0.8
Locomotor activity	1.2	1.9	2.8	1.4	1.4	1.4	-1.7	-1.4	-1.0
Locomotor testing distance	1.4	2.3	3.2	1.7	1.5	1.5	-1.8	-1.5	-1.1
Locomotor testing rearing	0.4	0.6	1.5	1.2	0.8	0.6	-0.7	-0.7	0.2
Locomotion in novel chamber	3.7	4.5	8.1	2.9	2.4	2.1	-2.2	-2.0	-0.6
Locomotion in novel chamber post-restriction	2.8	3.3	4.9	2.2	1.9	1.8	-1.6	-2.2	-1.1
Fecal boli incidents, locomotor time 1	0.0	0.0	0.1	0.2	0.2	0.2	0.1	-0.1	-0.0
Change in fecal boli incidents, locomotor task	0.4	0.4	0.5	-0.5	-0.7	-0.7	0.6	0.4	0.7
Time >=10cm from walls, locomotor time 1	0.6	0.6	2.0	1.2	0.1	-0.1	0.3	0.0	1.4
Bouts of movement, locomotor time 1	0.2	0.3	0.9	-1.0	-0.3	-0.2	0.0	-0.4	-0.6
Total resting periods, locomotor time 1	0.2	0.2	0.4	-0.6	-0.0	0.1	-0.3	-0.5	-0.7
Rest time, locomotor task time 1	2.8	3.1	3.8	1.5	1.8	1.8	-2.0	-1.8	-1.6
Distance moved, locomotor task time 1	1.0	1.1	1.6	-0.4	-0.9	-1.0	1.2	1.3	1.2
Vertical activity count, locomotor time 1	0.2	0.2	1.0	1.0	0.5	0.4	-0.1	-0.0	0.1
Time >=10cm from walls, locomotor time 2	0.2	0.2	0.3	0.4	0.6	0.6	-0.5	0.1	-0.3
Bouts of movement, locomotor time 2	0.3	0.4	0.6	-0.7	-0.6	-0.5	0.7	0.7	0.1
Total resting periods, locomotor time 2	0.2	0.2	0.5	-0.4	-0.4	-0.4	0.7	0.6	0.1
Rest time, locomotor task time 2	0.9	1.0	3.1	1.8	0.9	0.7	-0.5	-1.2	-0.0
Distance moved, locomotor task time 2	0.2	0.3	1.1	-1.0	-0.4	-0.2	0.1	0.6	-0.3
Vertical activity count, locomotor time 2	0.7	0.8	2.2	-0.2	0.7	0.9	-1.1	-0.3	-1.5
Light reinforcement 1	0.7	1.3	1.7	1.0	1.3	1.3	-1.1	-1.2	-1.0
Light reinforcement 2	2.4	3.2	4.5	2.0	2.1	2.0	-1.6	-1.6	-1.3
Bone: marrow area	0.4	0.8	3.4	1.8	0.8	0.5	0.1	-0.2	0.8
Bone: maximum diameter	0.2	0.3	0.4	0.5	0.6	0.6	-0.5	-0.6	-0.6
Bone: maximum force	2.9	5.0	6.1	-1.6	-2.4	-2.5	2.5	2.1	2.3
Bone: maximum moment	2.5	4.2	5.2	-1.5	-2.2	-2.3	2.3	1.9	2.1
Mean time between licks in bursts	0.5	0.7	1.2	-1.1	-1.0	-0.9	0.6	0.7	0.3
Mean num. licks in bursts	0.1	0.1	0.2	0.2	-0.3	-0.3	0.4	0.2	0.3
Cd content in liver	1.5	1.6	2.2	1.4	1.5	1.4	-1.2	-1.2	-0.8
Co content in liver	0.9	1.1	1.8	0.4	1.1	1.2	-1.1	-0.9	-1.4
Cu content in liver	0.1	0.1	0.2	-0.5	-0.2	-0.2	0.3	0.2	-0.1
Fe content in liver	0.0	0.0	0.1	-0.3	-0.2	-0.1	0.0	0.1	0.1
K content in liver	2.9	2.9	4.0	-1.3	-1.8	-1.8	2.0	1.5	1.7
Mg content in liver	2.0	2.0	3.8	-0.1	-1.1	-1.3	1.9	1.3	1.9
Mn content in liver	1.3	1.5	2.3	-1.5	-1.3	-1.2	1.3	1.1	0.6
Na content in liver	0.2	0.2	0.5	-0.2	0.2	0.3	-0.5	-0.5	-0.7
Rb content in liver	0.6	0.7	1.9	1.4	0.1	-0.2	0.7	0.5	1.3
Se content in liver	0.2	0.2	0.8	0.5	-0.2	-0.3	0.3	0.2	0.9
Sr content in liver	0.6	0.6	2.3	-1.5	-0.8	-0.6	0.1	0.3	-0.4
Zn content in liver	0.5	0.6	1.3	-1.1	-0.9	-0.8	0.6	0.5	0.2
Bone: minimum diameter	0.4	0.8	2.2	1.5	0.1	-0.2	0.7	0.3	1.4
Time in familiar zone, hab. session 1	0.1	0.1	0.4	0.7	0.3	0.2	-0.0	-0.0	0.2
Time in novel zone, hab. session 1	0.0	0.0	0.0	-0.1	-0.0	0.0	-0.1	-0.1	-0.1
Total zone transitions, hab. session 1	0.6	0.8	1.5	-1.2	-0.9	-0.9	0.8	0.8	0.7
Total locomotion distance, hab. session 1	0.1	0.2	0.4	0.4	0.6	0.5	-0.4	-0.3	0.1
Locomotion velocity, hab. session 1	0.0	0.0	0.1	-0.0	0.3	0.3	-0.2	-0.2	0.1
Time in familiar zone, hab. session 2	0.2	0.2	0.5	-0.7	-0.2	-0.1	-0.2	-0.1	-0.6
Time in novel zone, hab. session 2	0.5	0.5	1.3	0.3	-0.4	-0.6	0.9	0.7	1.1
Total zone transitions, hab. session 2	4.3	5.5	7.5	-1.6	-2.3	-2.5	2.5	2.3	2.7
Total locomotion distance, hab. session 2	0.7	0.9	2.1	-0.4	-0.8	-0.9	1.0	0.9	1.5
Locomotion velocity, hab. session 2	0.4	0.6	1.7	-0.1	-0.4	-0.6	0.8	0.7	1.3
Novel to familiar place preference ratio	0.6	0.6	0.9	-0.3	-0.7	-0.8	0.9	0.8	0.9
Novelty place preference	0.4	0.4	0.7	0.0	-0.5	-0.6	0.8	0.6	0.8
Time in novel zone, NPP test	0.4	0.4	0.7	0.0	-0.5	-0.6	0.8	0.7	0.9
Total zone transitions, NPP test	1.9	2.6	3.0	-1.7	-1.6	-1.7	1.5	1.5	1.6
Total locomotion distance, NPP test	0.1	0.2	0.5	-0.4	-0.3	-0.4	0.3	0.4	0.7
Locomotion velocity, NPP test	0.1	0.1	0.3	-0.3	-0.1	-0.2	0.1	0.2	0.5
Intraocular pressure	1.3	1.8	2.5	0.6	1.3	1.4	-1.5	-1.3	-1.6
Delta distance traveled before/after self-admin	0.1	0.1	0.3	0.1	0.1	0.1	-0.6	-0.0	0.0
Delta ambulatory time before/after self-admin	0.0	0.0	0.2	-0.0	-0.0	0.0	-0.4	0.2	0.1
Parametrial fat weight	0.5	0.9	3.1	1.8	1.1	0.8	-0.3	-0.5	0.4
Pavlov. Cond. lever latency	0.3	0.4	0.8	0.9	0.6	0.6	-0.6	-0.5	-0.5
Pavlov. Cond. magazine entry latency	0.5	0.6	1.8	0.2	-0.5	-0.7	0.9	0.7	1.3
Pavlov. Cond. change in total contacts	0.1	0.1	0.3	0.5	0.2	0.1	0.2	0.0	0.6
Pavlov. Cond. index score	0.0	0.0	0.0	-0.0	0.2	0.1	-0.0	-0.1	0.2
Pavlov. Cond. latency score	0.0	0.0	0.2	-0.1	-0.0	-0.1	0.2	0.1	0.4
Pavlov. Cond. lever contacts	0.1	0.1	0.3	-0.6	-0.2	-0.3	0.4	0.3	0.4
Pavlov. Cond. magazine entry number	0.1	0.1	0.1	-0.1	-0.3	-0.3	0.3	0.3	0.1
Pavlov. Cond. intertrial magazine entries	0.6	0.8	1.2	0.6	0.9	0.9	-0.9	-0.8	-1.1
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.1	-0.2	0.0	-0.0	0.1	0.1	0.2
Pavlov. Cond. response bias	0.0	0.0	0.0	-0.0	0.2	0.1	0.0	-0.1	0.1
Pavlov. Cond. lever latency	0.0	0.0	0.1	0.1	0.2	0.3	-0.1	-0.1	-0.2
Pavlov. Cond. magazine entry latency	3.8	4.4	5.6	-1.8	-2.4	-2.4	2.2	2.0	1.9
Pavlov. Cond. change in total contacts	0.6	0.8	1.2	-0.5	-1.0	-1.0	1.0	0.8	1.1
Pavlov. Cond. index score	1.1	1.4	1.8	-1.1	-1.3	-1.3	1.1	1.0	1.1
Pavlov. Cond. latency score	0.8	1.0	1.3	-0.9	-1.1	-1.2	0.9	0.9	1.0
Pavlov. Cond. lever contacts	0.0	0.0	0.0	-0.1	0.0	0.1	-0.2	-0.2	-0.2
Pavlov. Cond. magazine entry number	5.0	6.1	7.4	2.3	2.7	2.7	-2.5	-2.3	-2.2
Pavlov. Cond. intertrial magazine entries	1.4	1.8	2.6	1.6	1.5	1.5	-1.3	-1.2	-1.0
Pavlov. Cond. lever-magazine prob. diff.	1.5	1.9	2.4	-1.3	-1.5	-1.5	1.4	1.2	1.2
Pavlov. Cond. response bias	0.7	0.9	1.2	-0.9	-1.1	-1.1	0.9	0.9	0.8
Time in closed arm before self-admin	0.1	0.1	0.3	0.5	0.2	0.2	-0.0	0.4	0.2
Time in closed arm after self-admin	0.0	0.0	0.1	-0.3	0.0	0.1	0.2	-0.3	-0.2
Time in open arm before self-admin	0.1	0.1	0.4	-0.6	-0.4	-0.3	0.0	-0.0	-0.1
Time in open arm after self-admin	0.0	0.0	0.1	-0.1	0.0	0.1	-0.4	-0.1	-0.3
Bone: periosteal estimation	0.1	0.1	0.4	0.6	0.3	0.3	-0.1	-0.2	0.0
Bone: periosteal perimeter	0.1	0.1	0.3	0.6	0.0	-0.1	0.3	0.1	0.6
Bone: post-yield work	3.4	4.7	11.5	0.6	-1.5	-1.9	2.5	2.0	3.4
Progressive ratio test 1 active lever presses	1.1	1.1	2.0	1.4	1.3	1.2	-0.7	-0.8	-0.6
Progressive ratio test 1 breakpoint	1.1	1.1	2.0	1.4	1.3	1.2	-0.7	-0.8	-0.7
Progressive ratio test 1 inactive lever presses	0.2	0.2	0.4	0.6	0.5	0.5	0.2	0.1	0.1
Progressive ratio test 2 active lever presses	1.8	1.9	3.6	1.9	1.6	1.5	-1.0	-1.2	-0.5
Progressive ratio test 2 breakpoint	2.9	3.3	4.8	2.2	2.1	2.0	-1.5	-1.7	-1.0
Progressive ratio test 2 inactive lever presses	3.3	3.8	9.2	3.0	2.4	2.1	-1.3	-1.3	-0.4
Incentive Sensitization - Responses	0.1	0.1	0.2	0.5	0.4	0.3	-0.3	-0.5	0.1
Incentive Sensitization - Breakpoint	0.3	0.3	0.4	0.7	0.6	0.5	-0.4	-0.6	0.0
Sum of active levers in priming session hrs 5-6	1.2	1.2	2.5	-0.3	0.8	1.0	-1.4	-0.8	-1.6
Progressive ratio	4.6	5.4	7.0	-1.5	-2.5	-2.6	2.4	2.3	2.5
Food seeking constrained by brief footshock	0.4	0.4	0.9	-0.6	-0.7	-0.7	0.4	0.9	0.4
Seeking ratio, punishment vs. effort	2.6	3.2	4.4	1.1	2.0	2.1	-1.8	-1.5	-2.0
Retroperitoneal fat weight	3.3	10.9	20.0	4.5	3.8	3.5	-2.8	-2.9	-1.5
Reaction time number correct	0.1	0.2	0.7	-0.8	-0.2	-0.0	-0.3	-0.2	-0.6
Reaction time mean minus median	2.2	2.9	3.4	-1.6	-1.8	-1.8	1.8	1.8	1.3
Reaction time mean minus median AUC	1.1	1.4	2.4	-1.6	-1.3	-1.3	1.1	1.2	0.5
Reaction time num false alarms	0.3	0.5	1.3	-0.0	0.4	0.6	-0.8	-0.6	-1.1
Reaction time num false alarms AUC	0.1	0.2	0.6	-0.8	-0.3	-0.2	-0.2	-0.1	-0.7
Reaction time trials correct on left	0.1	0.2	0.7	-0.8	-0.2	-0.0	-0.3	-0.2	-0.6
Reaction time trials on left	0.2	0.2	0.9	-0.9	-0.2	-0.0	-0.3	-0.1	-0.6
Reaction time mean	0.2	0.2	0.5	-0.1	-0.4	-0.4	0.5	0.6	0.7
Reaction time mean AUC	0.2	0.2	0.6	0.0	-0.3	-0.4	0.5	0.6	0.8
Median of all reaction times	0.1	0.2	0.5	0.2	-0.1	-0.2	0.4	0.4	0.7
Reaction time omissions	1.2	1.6	2.9	-1.7	-1.4	-1.3	1.2	1.2	0.6
Reaction time false alarm rate	0.1	0.1	0.4	-0.1	0.0	0.1	-0.3	-0.2	-0.6
Reaction time premature initiation rate	1.5	2.0	3.6	-1.9	-1.7	-1.6	1.0	1.2	0.7
Reaction time premature initiations	1.7	2.4	6.4	-2.5	-1.8	-1.6	0.9	1.1	0.3
Std. dev. reaction times	0.7	1.0	1.3	-0.8	-1.0	-1.0	1.0	1.1	0.8
Reaction time trials completed	0.2	0.2	0.9	-0.9	-0.2	-0.0	-0.3	-0.1	-0.6
Reaction time trials AUC	0.1	0.2	0.6	-0.8	-0.2	-0.0	-0.2	-0.1	-0.5
Run reversals in cocaine runway, females	2.9	2.8	3.2	-1.3	-1.7	-1.8	1.8	1.7	1.7
Run reversals in cocaine runway, males	0.3	0.3	0.9	-0.2	0.2	0.4	-1.0	-0.5	-0.8
Latency to leave start box in cocaine runway	0.4	0.5	1.2	0.2	-0.5	-0.6	0.7	0.7	1.1
Latency to leave start box in cocaine runway, F	0.4	0.4	0.9	-0.0	-0.5	-0.6	0.6	0.9	0.9
Latency to leave start box in cocaine runway, M	0.0	0.0	0.0	0.1	0.0	-0.0	-0.1	-0.1	0.1
Std. dev. time between licks in bursts	0.3	0.4	0.8	-0.9	0.0	0.2	-0.7	-0.3	-0.9
Total sessions with >9 infusions	0.2	0.2	0.8	0.9	0.5	0.4	0.1	-0.3	0.3
Short access day 1 total inactive lever presses	1.2	1.3	3.5	1.9	1.4	1.3	-0.6	-0.2	-0.4
Short access day 10 total inactive lever presses	0.6	0.6	1.5	1.2	1.0	0.9	-0.8	0.0	-0.2
Short access day 1 total infusions	0.6	0.7	2.9	1.7	0.7	0.5	0.0	0.1	0.6
Short access day 10 total infusions	1.0	1.2	3.3	0.8	-0.5	-0.8	1.3	0.7	1.8
Short access total infusions	0.4	0.4	1.2	0.8	-0.1	-0.3	0.8	0.3	1.1
Short access day 1 locomotion	0.4	0.4	1.6	1.3	0.5	0.3	0.3	-0.0	0.7
Short access day 10 total locomotion	0.2	0.2	0.6	0.6	0.2	0.0	0.5	0.2	0.8
Short access total locomotion	0.4	0.4	0.7	0.7	0.0	-0.1	0.9	0.6	0.8
One hour access (0.3 mA shock)	4.3	5.1	10.8	3.3	2.6	2.4	-1.8	-1.8	-0.9
Compulsive drug intake	1.4	1.4	3.5	-1.9	-1.4	-1.1	0.9	0.9	-0.1
One hour access (shock baseline)	5.3	6.1	11.8	3.4	3.0	2.7	-2.0	-1.9	-1.0
Social response proportion	1.3	1.5	1.7	-0.9	-1.2	-1.3	1.3	1.2	1.2
Social responses	0.2	0.2	0.6	-0.8	-0.4	-0.4	0.5	0.5	0.1
Social time	0.5	0.7	0.9	-0.9	-0.9	-0.8	0.9	0.9	0.5
Soleus weight	4.1	12.0	15.8	3.5	4.0	3.9	-3.4	-3.2	-2.6
Bone: stiffness	2.7	4.2	5.2	-1.3	-2.1	-2.2	2.3	2.0	2.3
Tibialis anterior weight	3.1	10.4	33.8	-5.8	-3.4	-2.7	2.2	2.2	-0.5
Time to tail flick, vehicle, before self-admin	1.6	1.6	2.5	-0.5	-1.5	-1.6	1.3	0.9	1.6
Time to tail flick, vehicle, after self-admin	2.9	3.1	4.1	-1.9	-1.8	-1.8	2.0	1.7	1.3
Time to tail flick, test, before self-admin	1.1	1.0	2.4	-0.0	-0.7	-0.9	1.3	1.0	1.5
Time to tail flick, test, after self-admin	0.0	0.0	0.1	-0.0	-0.2	-0.2	0.0	-0.1	-0.0
Delta time to tail flick, vehicle, before/after SA	0.9	0.9	1.8	-1.3	-0.8	-0.7	1.3	0.9	0.4
Delta time to tail flick, test, before/after SA	0.9	0.8	2.6	-0.4	0.2	0.5	-1.1	-0.9	-1.6
Tibia length	0.2	0.6	2.0	-0.4	0.4	0.6	-0.8	-0.6	-1.4
Ambulatory time before self-admin	0.1	0.1	0.2	-0.2	-0.4	-0.5	0.1	0.0	0.3
Ambulatory time after self-admin	0.2	0.2	0.6	0.7	0.0	-0.1	-0.2	0.2	0.7
Bone: tissue strength	0.1	0.1	0.1	0.3	0.1	0.0	0.3	0.1	0.3
Total heroin consumption	2.7	3.1	5.3	-2.3	-2.1	-1.9	1.8	1.4	0.7
Bone: trabecular number	1.7	2.7	5.0	-0.5	-1.7	-1.9	1.5	1.4	2.2
Bone: trabecular spacing	0.5	0.6	1.2	0.1	0.9	1.0	-0.4	-0.6	-1.1
Bone: trabecular thickness	0.4	0.5	1.6	1.1	-0.2	-0.4	0.1	0.2	1.3
Bone: trabecular tissue density	5.4	7.6	10.4	2.5	3.2	3.2	-2.8	-2.5	-2.2
Water consumed over 24 hours	0.8	1.0	1.3	-0.9	-1.1	-1.1	1.0	0.9	0.9
Number of responses in last shaping day	0.3	0.4	0.7	0.7	0.8	0.8	-0.4	-0.1	-0.5