Hub : Genes

Vps51

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver intron excision ratio chr1_212793428_212798857 0.18 0.08 2.7e-15 0.1 0.09 0.09 0.09 2.0e-11 1.1e-09 7.3e-10 6.2e-10
2 Liver intron excision ratio chr1_212794727_212798857 0.13 0.06 3.7e-13 0.09 0.07 0.07 0.07 3.4e-10 2.2e-08 3.4e-08 2.3e-08
3 pVTA mRNA stability Vps51 0.03 0.02 3.5e-03 0.02 0.01 0.01 0.01 5.2e-03 4.8e-02 6.2e-02 8.0e-02
4 Liver gene expression Vps51 0.1 0.05 2.5e-10 0.06 0.08 0.07 0.08 2.7e-07 2.7e-09 2.9e-08 5.8e-09
5 Eye mRNA stability Vps51 0.31 0.15 6.0e-03 0.02 0 -0.02 0.01 1.4e-01 3.1e-01 6.5e-01 2.5e-01
6 pVTA gene expression Vps51 0.12 0.06 2.0e-07 0.1 0.09 0.08 0.09 2.2e-08 2.2e-07 2.6e-07 1.6e-07
7 RMTg mRNA stability Vps51 0.17 0.1 3.3e-03 0.02 0 -0.01 0.01 9.5e-02 3.0e-01 6.6e-01 1.6e-01
8 NAcc gene expression Vps51 0.16 0.07 0.0e+00 0.12 0.13 0.13 0.13 3.3e-17 5.5e-19 1.6e-18 5.0e-19
9 IC gene expression Vps51 0.34 0.13 7.7e-11 0.12 0.26 0.25 0.25 6.7e-06 2.1e-11 5.5e-11 1.0e-10
10 BLA gene expression Vps51 0.51 0.15 6.6e-12 0.18 0.19 0.19 0.2 1.2e-09 3.0e-10 1.6e-10 8.4e-11
11 Brain gene expression Vps51 0.45 0.13 0.0e+00 0.25 0.29 0.28 0.29 1.2e-23 5.7e-27 1.1e-26 2.2e-27
12 PL gene expression Vps51 0.47 0.13 0.0e+00 0.2 0.24 0.24 0.24 2.1e-21 8.4e-26 1.6e-26 7.2e-26
13 Adipose gene expression Vps51 0.11 0.05 9.6e-09 0.05 0.06 0.06 0.06 5.1e-06 9.3e-08 1.0e-07 2.8e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density1.11.83.7-0.90.90.9-1.50.7-0.8-0.6-1.9-1.6-1.9-1.5-1.8-1.4
Area under the delay curve0.20.31.00.3-0.30.0-0.00.3-0.8-1.0-0.6-0.5-0.2-0.2-0.5-0.9
BMI with tail3.211.223.5-2.62.62.3-3.62.0-1.5-1.5-4.7-3.6-4.8-3.9-4.4-3.5
BMI without tail0.92.86.2-1.41.41.5-1.71.6-0.6-1.0-2.5-1.5-2.2-1.7-1.9-1.9
Body weight1.87.714.4-3.73.73.7-3.83.61.21.1-2.8-1.3-3.4-1.8-2.2-1.0
Weight adjusted by age0.81.12.1-1.41.41.4-1.41.51.41.3-0.10.3-0.20.40.50.9
Bone surface3.25.815.1-3.23.23.0-3.92.20.51.3-2.6-1.8-2.8-1.3-1.9-0.5
Bone volume1.83.38.1-1.81.81.7-2.81.0-0.40.3-2.5-2.1-2.5-1.6-2.0-1.1
Breakpoint value in progressive ratio session1.62.04.9-2.22.22.0-2.21.60.91.3-1.2-0.3-0.60.3-0.00.4
Number of licking bursts0.10.20.6-0.60.60.6-0.80.40.20.4-0.5-0.2-0.20.0-0.00.1
Context. condit. distance diff. score1.01.32.71.7-1.7-1.61.5-1.1-1.1-1.40.3-0.20.2-0.4-0.3-0.8
Locomotion velocity, session 10.20.20.70.1-0.10.10.50.60.70.20.80.80.20.30.40.4
Locomotion distance, session 10.60.81.6-0.70.70.7-0.71.0-0.2-0.6-1.2-0.7-1.3-1.0-1.1-1.1
Locomotion velocity, session 21.51.83.7-1.81.81.8-1.81.90.60.6-1.4-0.5-1.3-0.6-0.9-0.4
Locomotion distance, session 20.50.71.4-0.90.90.9-0.81.20.1-0.3-1.2-0.4-0.8-0.7-0.7-0.8
Locomotion velocity, session 31.11.33.00.3-0.3-0.60.2-0.3-0.9-1.3-0.9-1.1-1.7-1.7-1.7-1.6
Locomotion distance, session 30.00.00.10.0-0.0-0.30.2-0.0-0.1-0.3-0.1-0.0-0.3-0.2-0.1-0.2
Stereotopy head waving bouts, day 31.41.63.70.9-0.9-1.00.6-0.5-1.0-1.5-0.6-1.0-1.7-1.9-1.8-1.7
Stereotopy head waving duration, day 30.81.01.71.0-1.0-0.90.5-0.8-1.0-1.2-0.4-0.9-1.0-1.3-1.2-1.2
Locomotion velocity, session 71.82.04.10.7-0.7-0.7-0.1-0.7-1.7-1.8-1.6-1.7-1.6-1.8-1.8-2.0
Locomotion distance, session 70.30.41.10.0-0.0-0.30.30.2-0.6-0.9-0.6-0.4-0.7-0.8-0.8-1.1
Stereotopy head waving bouts, day 70.60.61.70.2-0.2-0.0-0.7-0.5-0.9-0.5-1.1-1.3-1.0-1.0-0.9-0.8
Stereotopy head waving duration, day 70.70.82.6-0.80.81.0-1.60.5-0.40.0-1.4-1.2-0.9-0.6-0.7-0.6
Locomotion velocity, session 80.81.02.6-1.11.11.0-0.21.61.51.10.61.10.10.40.40.8
Locomotion distance, session 80.71.12.40.6-0.6-0.60.2-0.4-1.0-1.1-0.9-1.0-1.3-1.6-1.5-1.4
Degree of sensitization distance0.60.61.7-0.00.0-0.1-0.10.1-0.6-0.6-0.7-0.7-1.2-1.2-1.3-1.1
Degree of sensitization stereotypy0.60.62.1-0.70.70.8-1.40.1-0.40.2-1.3-1.1-0.7-0.4-0.6-0.4
Conditioned locomotion0.80.92.1-1.51.51.3-1.11.31.11.1-0.20.3-0.50.1-0.00.5
Cocaine response after cond. corrected0.81.02.81.4-1.4-1.51.7-0.9-0.5-1.20.80.30.0-0.4-0.3-0.6
Cocaine response after cond. not corrected0.60.71.91.2-1.2-1.21.4-0.7-0.4-1.00.60.1-0.2-0.5-0.4-0.6
Cocaine response before conditioning0.50.61.6-1.11.11.2-1.30.60.30.8-0.7-0.3-0.30.20.10.3
Saline control response2.23.07.1-2.52.52.6-1.82.72.01.8-0.20.7-0.50.40.20.9
Bone: connectivity density1.82.96.1-2.22.22.0-2.51.70.00.2-2.0-1.3-2.0-1.1-1.6-0.9
Bone: cortical apparent density0.50.62.0-0.40.40.20.10.20.50.40.50.81.41.41.40.9
Bone: cortical area0.50.71.7-1.11.11.2-1.30.80.60.9-0.6-0.3-0.8-0.2-0.50.3
Bone: cortical porosity0.10.10.4-0.30.30.4-0.60.3-0.2-0.1-0.6-0.4-0.3-0.2-0.3-0.3
Bone: cortical porosity0.30.30.8-0.70.70.8-0.90.80.10.2-0.7-0.3-0.5-0.2-0.4-0.2
Bone: cortical thickness2.33.96.2-2.22.22.4-1.12.42.52.30.81.81.12.01.72.0
Bone: cortical thickness1.21.42.9-0.80.80.70.41.21.41.01.11.71.21.51.41.2
Bone: cortical tissue density0.60.82.2-0.50.50.4-0.00.40.60.60.51.01.51.51.51.0
Condit. Reinf. active minus inactive responses0.10.10.4-0.30.30.4-0.40.5-0.1-0.2-0.6-0.2-0.00.0-0.1-0.3
Condit. Reinf. active-inactive response ratio0.10.10.60.1-0.10.2-0.00.20.0-0.1-0.10.20.80.80.60.2
Condit. Reinf. active responses0.30.41.0-0.10.1-0.0-0.4-0.0-0.6-0.5-1.0-0.8-0.7-0.7-0.8-0.8
Condit. Reinf. inactive responses1.01.23.10.2-0.2-0.4-0.4-0.6-1.1-0.8-1.1-1.4-1.7-1.8-1.7-1.3
Incentive salience index mean0.40.51.5-0.50.50.5-0.80.6-0.4-0.5-1.2-0.8-0.9-0.7-0.9-0.9
Condit. Reinf. lever presses0.81.12.5-0.80.80.7-1.30.4-0.30.0-1.4-1.2-1.6-1.2-1.4-0.9
Condit. Reinf. active minus inactive responses0.20.20.60.1-0.1-0.3-0.4-0.7-0.6-0.1-0.6-0.8-0.5-0.5-0.4-0.3
Condit. Reinf. active-inactive response ratio1.31.52.90.8-0.8-0.9-0.3-1.5-1.4-0.7-0.9-1.7-1.5-1.7-1.5-1.1
Condit. Reinf. active responses0.20.20.9-0.50.50.3-0.8-0.0-0.4-0.0-1.0-0.6-0.2-0.1-0.1-0.2
Condit. Reinf. inactive responses0.40.51.2-0.90.90.9-0.51.10.40.1-0.50.40.70.80.60.2
Condit. Reinf. lever presses1.21.65.1-1.81.81.6-2.30.90.51.2-1.5-0.9-1.2-0.3-0.60.1
Condit. Reinf. lever reinforcers received0.20.31.1-0.80.80.7-1.00.2-0.00.3-0.9-0.4-0.10.10.10.1
Conditioned reinforcement - actives0.10.20.80.1-0.10.1-0.9-0.60.20.90.0-0.7-0.5-0.4-0.10.5
Conditioned reinforcement - inactives1.21.86.51.9-1.9-2.01.0-2.6-1.5-0.90.6-0.90.3-0.5-0.1-0.2
Conditioned locomotion3.74.812.63.3-3.3-3.32.6-3.6-1.9-1.61.4-0.41.2-0.30.3-0.3
Patch foraging indifference point 0 sec0.00.00.1-0.10.10.00.0-0.1-0.3-0.3-0.3-0.2-0.0-0.1-0.2-0.3
Patch foraging indifference point AUC1.21.83.9-1.81.81.9-2.01.31.31.8-0.40.10.20.90.61.1
Delay disc. indifference point, 0s delay0.70.82.01.0-1.0-0.30.30.1-1.2-1.4-0.6-0.8-0.5-0.8-1.1-1.4
Delay disc. indifference point, 16s delay0.60.72.00.8-0.8-0.90.3-1.0-1.3-1.4-0.8-0.8-0.0-0.4-0.5-0.9
Delay disc. indifference point, 2s delay0.30.40.90.5-0.5-0.2-0.1-0.2-0.8-0.7-0.4-0.8-0.6-0.7-0.9-0.8
Delay disc. indifference point, 24s delay0.20.20.60.3-0.3-0.10.70.20.3-0.10.60.80.60.70.50.3
Delay disc. indifference point, 4s delay0.20.21.00.5-0.5-0.20.40.4-0.7-1.0-0.1-0.1-0.0-0.2-0.4-0.8
Delay disc. indifference point, 8s delay0.10.10.40.3-0.30.00.30.5-0.3-0.70.10.1-0.0-0.0-0.1-0.5
Indifference point function ln k3.56.114.93.5-3.5-3.63.9-2.8-2.0-2.91.40.20.5-1.0-0.6-1.5
Indifference point function log k3.56.114.93.5-3.5-3.63.9-2.8-2.0-2.91.40.20.5-1.0-0.6-1.5
Patch foraging total patch changes 0 sec0.00.10.2-0.20.20.10.30.20.20.10.30.40.40.30.30.2
Patch foraging total patch changes 12 sec2.33.07.3-2.62.62.7-2.42.41.31.6-1.20.0-0.30.70.30.6
Patch foraging total patch changes 18 sec0.30.51.6-0.90.91.1-1.30.80.10.4-0.8-0.6-0.5-0.2-0.4-0.1
Patch foraging total patch changes 24 sec1.22.03.8-1.81.81.9-1.31.71.81.90.20.90.31.00.81.3
Patch foraging total patch changes 6 sec0.50.82.2-1.51.51.3-0.91.30.70.6-0.40.2-0.20.2-0.10.1
Patch foraging time to switch 0 sec1.83.78.4-1.71.71.7-2.61.2-0.9-0.4-2.9-2.2-2.5-1.8-2.0-1.6
Patch foraging water rate 0 sec2.24.711.02.7-2.7-2.73.3-2.40.1-0.23.01.72.31.21.51.1
Patch foraging water rate 12 sec4.28.824.13.9-3.9-3.84.9-2.7-0.2-1.34.02.32.91.31.80.9
Patch foraging water rate 18 sec1.62.58.12.2-2.2-2.22.8-1.5-0.3-1.02.11.11.00.10.40.0
Patch foraging water rate 24 sec2.63.69.72.7-2.7-2.63.1-2.1-0.2-0.92.61.21.50.40.70.5
Patch foraging water rate 6 sec3.24.714.12.7-2.7-2.83.8-1.90.2-0.73.32.01.90.91.10.7
Seeking ratio, delayed vs. immediate footshock0.30.41.30.2-0.2-0.50.2-0.4-1.2-1.1-0.8-0.6-0.2-0.5-0.1-0.9
Distance traveled before self-admin0.60.82.7-0.90.91.0-1.70.4-0.30.2-1.4-1.1-1.0-0.6-0.8-0.4
Distance traveled after self-admin0.20.30.5-0.60.60.6-0.70.30.20.4-0.30.10.60.70.60.4
Extensor digitorum longus weight3.814.833.8-5.85.85.8-5.35.43.23.3-2.5-0.0-2.30.0-0.50.9
Bone: elastic displacement1.61.95.11.1-1.1-1.02.1-0.50.90.32.31.91.61.21.31.1
Bone: elastic work1.01.32.8-1.11.11.10.11.61.71.21.01.60.61.00.91.1
Bone: endosteal estimation2.14.610.41.1-1.1-1.1-0.1-1.3-2.2-2.0-1.8-2.5-2.9-3.2-3.2-2.6
Bone: endosteal perimeter2.65.511.41.4-1.4-1.4-0.3-1.9-2.5-2.0-2.0-3.0-3.1-3.4-3.3-2.7
Epididymis fat weight1.96.515.03.6-3.6-3.52.0-3.9-2.6-2.20.3-1.7-1.0-2.2-1.8-1.6
Delta time in closed arm before/after self-admin0.40.41.3-0.30.30.40.71.20.90.10.61.10.30.30.10.2
Delta time in open arm before/after self-admin0.30.31.4-0.50.50.5-1.2-0.2-0.00.7-0.5-0.5-0.00.30.20.5
Diff in mean of infusions in LGA sessions0.40.40.8-0.90.90.8-0.60.80.90.80.00.50.10.40.50.6
Delay discount exponential model param0.20.20.6-0.20.2-0.10.0-0.40.70.80.50.30.10.10.30.7
Extinction: sum of active levers before priming1.51.74.2-1.81.81.7-2.01.50.20.4-1.7-0.8-0.9-0.4-0.6-0.4
Active lever presses in extinction session 61.91.95.4-1.81.82.0-2.31.41.31.7-0.8-0.4-1.0-0.2-0.50.6
Bone: final force1.52.45.1-2.32.32.1-2.31.81.01.3-1.2-0.5-1.5-0.5-0.90.1
Bone: final moment1.42.24.7-2.22.22.1-2.11.71.01.2-1.1-0.5-1.5-0.5-0.90.1
Food consumed during 24 hour testing period0.30.41.2-0.10.10.2-0.2-0.20.61.00.50.50.80.91.01.1
Glucose2.74.38.22.1-2.1-2.11.2-1.8-2.4-2.9-1.0-1.8-1.6-2.3-2.2-2.5
Heart weight2.23.47.21.5-1.5-1.20.9-0.5-1.9-2.7-1.1-1.5-1.9-2.5-2.5-2.7
Delay discount hyperbolic model param0.20.20.7-0.20.2-0.10.1-0.30.70.80.50.40.30.20.50.8
Intermittent access intake day 1-15 change0.40.83.11.3-1.3-1.40.7-1.8-0.7-0.20.7-0.30.4-0.10.20.2
Intermittent access intake escalation0.30.62.91.1-1.1-1.20.5-1.7-0.50.10.7-0.30.4-0.10.30.4
Intermittent access intake escalation 20.50.62.51.0-1.0-1.10.5-1.6-0.50.10.6-0.30.50.00.30.4
Intermitt. access day 1 inactive lever presses0.00.20.40.4-0.4-0.40.3-0.4-0.3-0.30.30.10.60.60.60.2
Intermitt. access day 15 inactive lever presses0.81.64.11.6-1.6-1.60.6-2.0-1.7-1.2-0.3-1.3-0.4-1.0-0.7-0.9
Intermitt. access escalation Index1.62.35.02.2-2.2-2.01.9-1.8-1.8-2.00.2-0.40.5-0.4-0.5-1.1
Intermittent access day 1 total infusions3.65.79.52.0-2.0-1.90.3-2.2-3.0-2.7-1.6-2.8-2.2-3.1-2.9-2.8
Intermittent access day 15 total infusions3.24.811.82.9-2.9-2.81.2-3.4-2.6-1.9-0.1-2.1-0.9-2.1-1.6-1.5
Intermittent access terminal intake (last 3 days)4.05.210.42.6-2.6-2.50.7-3.2-2.8-2.0-0.6-2.6-1.6-2.7-2.3-1.9
Intermittent access total infusions4.35.17.92.3-2.3-2.20.6-2.7-2.7-2.2-1.0-2.6-1.9-2.8-2.5-2.2
Intermittent access day 1 locomotion2.73.45.71.8-1.8-1.70.5-1.9-2.4-2.2-1.0-2.1-1.4-2.2-2.0-2.1
Intermittent access day 15 total locomotion2.44.310.32.4-2.4-2.50.6-3.2-2.7-1.9-0.5-2.3-1.0-2.0-1.6-1.5
Intermittent access total locomotion6.57.813.83.0-3.0-2.90.7-3.7-3.7-2.9-1.2-3.3-1.8-3.0-2.7-2.6
Intermittent access standard deviation0.40.92.71.5-1.5-1.41.0-1.6-0.6-0.30.8-0.20.5-0.20.10.1
Left kidney weight0.52.53.92.0-2.0-1.40.7-1.5-2.0-1.8-0.9-1.6-1.0-1.6-1.6-1.7
Right kidney weight0.20.71.91.4-1.4-1.10.7-1.2-0.7-0.60.2-0.5-0.3-0.7-0.6-0.5
Cocaine induced anxiety0.00.10.3-0.20.20.2-0.6-0.0-0.10.1-0.2-0.4-0.2-0.10.00.0
Post-drug Anxiety0.40.41.1-1.01.00.9-1.00.70.50.7-0.4-0.2-0.6-0.1-0.10.3
Baseline Anxiety0.40.41.0-0.70.70.60.10.91.00.80.30.90.20.60.50.6
Tail length0.72.65.0-1.01.01.4-0.21.82.21.81.22.01.51.81.91.8
Length with tail1.25.311.4-2.92.93.0-1.83.43.12.80.41.70.11.31.31.9
Length without tail1.44.59.6-2.82.82.7-1.43.13.02.60.61.8-0.01.21.01.8
Times rat made contact with spout0.30.41.1-0.60.60.8-0.31.00.40.2-0.30.50.60.80.70.3
Lifetime Intake3.23.96.52.0-2.0-1.90.6-2.2-2.4-2.0-0.8-2.2-1.7-2.6-2.3-2.1
Liver weight, left0.50.72.01.3-1.3-1.21.4-0.8-0.3-0.70.90.2-0.1-0.6-0.5-0.3
Liver weight, right1.22.06.02.1-2.1-2.02.5-1.2-0.7-1.41.40.4-0.1-0.9-0.6-0.8
Locomotor activity1.62.57.71.8-1.8-1.92.8-1.20.2-0.52.41.61.50.80.90.6
Locomotor testing distance1.93.410.72.2-2.2-2.13.3-1.30.4-0.62.91.91.80.91.10.7
Locomotor testing rearing1.42.88.42.2-2.2-1.92.9-1.2-0.0-0.92.31.51.70.90.90.4
Locomotion in novel chamber2.83.68.52.7-2.7-2.81.9-2.9-2.0-1.60.6-1.0-0.2-1.4-0.9-1.0
Locomotion in novel chamber post-restriction1.42.35.82.2-2.2-2.11.4-2.4-1.9-1.40.3-0.80.3-0.6-0.6-0.8
Fecal boli incidents, locomotor time 10.20.31.0-0.00.00.3-1.0-0.5-0.60.3-0.6-1.0-0.5-0.5-0.3-0.1
Change in fecal boli incidents, locomotor task0.20.20.4-0.10.1-0.30.60.40.2-0.6-0.00.2-0.3-0.4-0.6-0.6
Time >=10cm from walls, locomotor time 13.33.57.20.8-0.8-0.7-0.8-1.3-2.3-1.5-1.9-2.7-2.3-2.7-2.6-2.1
Bouts of movement, locomotor time 11.82.14.8-1.41.41.4-1.20.81.21.40.10.91.72.22.11.5
Total resting periods, locomotor time 11.11.22.8-1.21.21.1-1.10.50.71.1-0.10.41.41.71.61.2
Rest time, locomotor task time 10.70.92.61.4-1.4-1.31.1-1.6-0.6-0.40.8-0.10.5-0.2-0.0-0.0
Distance moved, locomotor task time 10.40.61.8-0.40.40.3-0.60.5-0.6-0.6-0.9-0.8-1.4-0.9-1.0-1.0
Vertical activity count, locomotor time 10.20.61.21.0-1.0-1.11.1-0.9-0.7-1.00.3-0.1-0.2-0.4-0.2-0.5
Time >=10cm from walls, locomotor time 20.10.20.9-0.10.10.2-0.9-0.2-0.40.2-0.6-0.8-0.2-0.2-0.2-0.0
Bouts of movement, locomotor time 20.30.41.1-0.90.90.6-0.70.50.20.4-0.40.20.71.10.80.5
Total resting periods, locomotor time 20.10.20.6-0.60.60.3-0.60.1-0.20.0-0.5-0.10.60.70.50.1
Rest time, locomotor task time 21.31.73.41.8-1.8-1.81.3-1.7-1.4-1.50.3-0.7-0.1-0.8-0.8-1.0
Distance moved, locomotor task time 20.81.01.7-1.21.21.3-0.91.31.21.20.30.70.20.90.81.0
Vertical activity count, locomotor time 20.91.32.90.0-0.0-0.01.00.41.40.91.71.71.11.21.41.4
Light reinforcement 10.10.30.90.4-0.4-0.00.5-0.10.20.10.80.61.00.80.80.6
Light reinforcement 20.40.62.11.1-1.1-0.80.1-1.4-0.9-0.30.3-0.9-0.4-0.8-0.5-0.2
Bone: marrow area2.24.910.81.1-1.1-1.2-0.0-1.3-2.3-2.1-1.8-2.6-3.0-3.3-3.3-2.8
Bone: maximum diameter0.40.82.3-0.60.60.6-1.3-0.00.10.7-0.9-1.0-1.5-1.1-1.2-0.2
Bone: maximum force2.54.510.4-2.62.62.5-3.21.80.30.8-2.5-1.7-2.8-1.6-2.0-0.8
Bone: maximum moment2.44.19.3-2.52.52.4-3.11.80.30.7-2.4-1.6-2.7-1.6-2.0-0.8
Mean time between licks in bursts0.30.71.7-0.60.60.50.51.31.10.50.91.30.60.60.70.6
Mean num. licks in bursts0.20.20.70.5-0.5-0.50.8-0.1-0.1-0.50.40.50.80.50.50.0
Cd content in liver0.70.82.91.1-1.1-1.20.3-1.7-1.3-0.6-0.2-0.9-0.0-0.3-0.2-0.4
Co content in liver2.63.07.31.3-1.3-1.22.3-0.50.60.12.32.12.72.12.21.3
Cu content in liver0.20.20.60.1-0.1-0.1-0.1-0.1-0.8-0.8-0.8-0.50.30.1-0.0-0.5
Fe content in liver0.20.20.8-0.40.40.4-0.20.30.90.70.50.3-0.5-0.3-0.20.4
K content in liver0.60.61.4-0.70.70.6-0.60.9-0.1-0.2-0.8-0.5-1.2-0.8-1.0-0.8
Mg content in liver0.40.41.00.6-0.6-0.60.7-0.2-0.7-1.0-0.2-0.2-0.3-0.5-0.6-0.9
Mn content in liver1.82.04.8-2.12.12.0-2.21.41.21.6-0.9-0.2-0.9-0.0-0.20.6
Na content in liver0.50.51.5-0.70.70.8-0.40.81.11.20.60.70.10.50.40.9
Rb content in liver1.11.33.31.6-1.6-1.71.8-1.2-1.0-1.50.40.10.4-0.1-0.1-0.7
Se content in liver0.20.20.90.4-0.4-0.4-0.3-1.0-0.5-0.1-0.3-0.7-0.4-0.5-0.4-0.2
Sr content in liver2.11.83.3-1.61.61.7-1.31.51.51.80.30.80.51.21.01.5
Zn content in liver0.20.20.6-0.50.50.8-0.50.80.10.0-0.30.10.40.40.30.0
Bone: minimum diameter2.34.27.71.0-1.0-1.0-0.2-1.2-2.5-2.3-2.1-2.5-2.3-2.6-2.8-2.7
Time in familiar zone, hab. session 10.50.50.90.5-0.5-0.50.2-0.6-0.9-0.8-0.5-0.7-0.5-0.9-0.7-0.9
Time in novel zone, hab. session 10.70.72.00.4-0.4-0.41.10.10.80.31.41.30.90.90.90.8
Total zone transitions, hab. session 10.30.41.1-1.01.00.9-1.00.80.10.2-1.1-0.3-0.20.20.1-0.1
Total locomotion distance, hab. session 10.60.91.60.6-0.6-0.70.1-0.7-1.1-1.2-1.0-1.1-1.0-1.2-1.1-1.2
Locomotion velocity, hab. session 10.30.51.10.1-0.1-0.2-0.3-0.2-0.7-0.8-1.0-0.9-0.8-0.8-0.9-0.9
Time in familiar zone, hab. session 20.40.51.5-0.00.00.10.90.50.80.31.21.20.60.50.40.5
Time in novel zone, hab. session 20.30.31.2-0.20.20.1-0.7-0.0-0.6-0.4-1.1-0.8-0.3-0.2-0.2-0.5
Total zone transitions, hab. session 21.62.04.8-1.31.31.3-1.71.5-0.4-0.7-2.2-1.3-1.7-1.3-1.4-1.4
Total locomotion distance, hab. session 21.21.63.40.1-0.1-0.1-0.40.3-1.1-1.5-1.7-1.4-1.6-1.7-1.8-1.8
Locomotion velocity, hab. session 21.52.14.10.3-0.3-0.3-0.4-0.1-1.3-1.7-1.8-1.7-1.9-2.0-2.0-2.0
Novel to familiar place preference ratio0.80.93.6-1.11.11.0-1.90.4-0.10.7-1.4-1.0-0.7-0.2-0.3-0.0
Novelty place preference0.50.52.2-0.70.70.6-1.50.1-0.30.3-1.2-1.0-0.5-0.1-0.2-0.1
Time in novel zone, NPP test0.30.41.5-0.60.60.5-1.20.1-0.20.3-1.0-0.8-0.4-0.1-0.2-0.1
Total zone transitions, NPP test1.31.84.2-1.91.91.9-2.11.80.40.5-1.7-0.6-1.2-0.5-0.6-0.3
Total locomotion distance, NPP test0.40.61.3-0.20.20.1-0.50.3-0.6-0.8-1.2-0.8-1.0-1.0-1.0-1.1
Locomotion velocity, NPP test0.40.51.5-0.30.30.2-0.60.3-0.6-0.7-1.2-0.8-0.9-0.8-0.9-1.0
Intraocular pressure0.70.93.21.2-1.2-1.30.7-1.8-0.10.41.10.11.00.50.90.8
Delta distance traveled before/after self-admin0.90.92.40.3-0.3-0.41.30.10.70.11.21.41.61.31.30.8
Delta ambulatory time before/after self-admin0.70.92.10.1-0.1-0.21.10.40.90.21.21.51.41.21.30.9
Parametrial fat weight2.66.010.03.0-3.0-3.01.6-3.2-3.1-2.7-0.7-2.1-1.3-2.4-2.0-2.3
Pavlov. Cond. lever latency0.30.40.90.5-0.5-0.50.8-0.50.2-0.00.90.60.90.60.80.6
Pavlov. Cond. magazine entry latency0.70.93.1-0.50.50.7-1.30.3-0.8-0.5-1.8-1.3-1.0-0.8-1.0-1.0
Pavlov. Cond. change in total contacts0.60.62.4-0.30.30.3-1.2-0.2-1.0-0.3-1.5-1.3-0.6-0.4-0.6-0.7
Pavlov. Cond. index score0.20.30.9-0.50.50.6-0.90.3-0.20.2-0.9-0.6-0.4-0.1-0.3-0.2
Pavlov. Cond. latency score0.20.30.9-0.30.30.5-0.80.3-0.4-0.1-0.9-0.7-0.6-0.4-0.6-0.5
Pavlov. Cond. lever contacts0.30.40.8-0.30.30.3-0.60.3-0.4-0.3-0.9-0.7-0.9-0.7-0.9-0.7
Pavlov. Cond. magazine entry number0.20.31.10.6-0.6-0.71.0-0.3-0.0-0.50.70.3-0.2-0.5-0.3-0.3
Pavlov. Cond. intertrial magazine entries0.40.41.00.8-0.8-1.00.7-1.0-0.30.00.60.20.90.50.60.4
Pavlov. Cond. lever-magazine prob. diff.0.40.51.5-0.70.70.8-1.20.4-0.30.1-1.2-0.8-0.5-0.2-0.5-0.4
Pavlov. Cond. response bias0.10.20.7-0.50.50.6-0.90.2-0.10.3-0.7-0.4-0.10.20.00.1
Pavlov. Cond. lever latency0.40.51.80.9-0.9-0.91.4-0.3-0.4-0.90.60.60.90.30.5-0.2
Pavlov. Cond. magazine entry latency2.32.87.3-2.42.42.7-2.72.20.81.1-1.7-0.6-0.80.2-0.20.1
Pavlov. Cond. change in total contacts1.11.76.7-1.61.61.7-2.60.6-0.10.8-1.9-1.4-1.0-0.3-0.5-0.1
Pavlov. Cond. index score1.52.06.6-1.91.92.0-2.61.20.41.0-1.7-1.0-1.2-0.3-0.6-0.0
Pavlov. Cond. latency score1.41.86.0-1.71.71.8-2.41.00.30.9-1.6-1.1-1.3-0.5-0.8-0.1
Pavlov. Cond. lever contacts0.40.51.9-0.90.90.9-1.40.30.40.9-0.7-0.6-0.8-0.2-0.40.2
Pavlov. Cond. magazine entry number3.74.512.23.2-3.2-3.23.5-2.4-1.2-1.81.90.60.8-0.5-0.1-0.6
Pavlov. Cond. intertrial magazine entries0.40.71.71.2-1.2-1.31.1-1.3-0.6-0.60.4-0.10.1-0.4-0.2-0.3
Pavlov. Cond. lever-magazine prob. diff.1.72.37.5-2.12.12.2-2.71.40.51.1-1.7-1.0-1.1-0.1-0.50.1
Pavlov. Cond. response bias1.21.65.1-1.71.71.9-2.31.20.61.1-1.3-0.8-1.0-0.1-0.40.2
Time in closed arm before self-admin0.50.61.40.5-0.5-0.6-0.3-1.0-1.1-0.6-0.7-1.2-0.7-0.9-0.7-0.7
Time in closed arm after self-admin0.20.20.60.4-0.4-0.70.8-0.4-0.5-0.70.0-0.1-0.0-0.5-0.3-0.5
Time in open arm before self-admin0.91.03.30.6-0.6-0.41.80.70.7-0.41.41.71.11.01.00.3
Time in open arm after self-admin0.30.41.0-0.10.10.30.20.50.70.40.60.90.71.00.80.7
Bone: periosteal estimation1.02.15.9-0.10.10.1-1.0-0.3-0.9-0.5-1.6-1.9-2.4-2.2-2.4-1.5
Bone: periosteal perimeter0.81.33.9-0.40.40.4-1.2-0.1-0.6-0.2-1.4-1.5-2.0-1.6-1.8-1.0
Bone: post-yield work7.010.222.3-0.90.90.6-3.1-0.3-2.9-2.1-4.7-4.5-4.3-3.9-4.3-3.7
Progressive ratio test 1 active lever presses0.30.40.90.7-0.7-0.6-0.0-0.9-0.6-0.3-0.2-0.8-0.5-0.7-0.7-0.4
Progressive ratio test 1 breakpoint0.30.30.80.6-0.6-0.5-0.1-0.9-0.6-0.2-0.3-0.8-0.5-0.7-0.7-0.4
Progressive ratio test 1 inactive lever presses0.00.10.30.3-0.3-0.3-0.0-0.5-0.3-0.0-0.0-0.20.30.20.30.1
Progressive ratio test 2 active lever presses1.72.05.61.8-1.8-1.80.6-2.4-1.7-1.0-0.3-1.5-0.6-1.4-1.0-0.9
Progressive ratio test 2 breakpoint1.71.95.61.8-1.8-1.80.6-2.4-1.6-0.9-0.2-1.4-0.6-1.3-1.0-0.8
Progressive ratio test 2 inactive lever presses3.65.815.23.4-3.4-3.31.8-3.9-3.0-2.30.1-1.8-0.1-1.6-1.0-1.4
Incentive Sensitization - Responses0.50.81.70.1-0.1-0.2-0.7-0.5-0.9-0.4-1.0-1.3-1.2-1.3-1.2-0.9
Incentive Sensitization - Breakpoint0.60.81.70.3-0.3-0.4-0.5-0.8-1.0-0.5-1.0-1.3-1.2-1.3-1.2-0.9
Sum of active levers in priming session hrs 5-61.71.66.0-1.21.21.1-1.40.21.62.40.50.40.60.91.12.0
Progressive ratio2.03.16.0-1.11.11.3-2.20.9-1.0-0.9-2.4-2.2-2.4-2.0-2.2-1.8
Food seeking constrained by brief footshock0.00.10.2-0.40.40.20.20.30.20.20.10.40.1-0.10.20.1
Seeking ratio, punishment vs. effort1.92.76.71.3-1.3-1.52.6-0.80.60.22.32.12.21.61.91.2
Retroperitoneal fat weight5.021.547.56.9-6.9-6.95.7-6.2-4.4-4.91.8-1.3-0.0-2.6-1.8-2.8
Reaction time number correct0.30.51.8-0.50.50.4-0.20.61.31.10.80.80.30.50.50.9
Reaction time mean minus median1.12.68.5-2.32.32.2-2.91.40.71.4-1.7-0.9-1.4-0.3-0.30.3
Reaction time mean minus median AUC0.51.23.6-1.61.61.6-1.91.00.91.3-0.6-0.2-0.70.20.20.7
Reaction time num false alarms0.50.72.90.6-0.6-0.91.7-0.00.3-0.51.31.20.90.50.60.1
Reaction time num false alarms AUC0.30.51.3-0.10.1-0.21.10.60.7-0.21.11.20.80.60.60.2
Reaction time trials correct on left0.30.51.8-0.50.50.4-0.20.61.31.10.80.80.30.50.50.9
Reaction time trials on left0.30.62.1-0.60.60.5-0.20.71.51.20.80.80.30.60.61.0
Reaction time mean0.10.20.7-0.30.30.0-0.8-0.3-0.40.2-0.6-0.6-0.20.00.30.1
Reaction time mean AUC0.10.20.8-0.30.3-0.0-0.9-0.4-0.7-0.1-0.8-0.8-0.3-0.10.1-0.2
Median of all reaction times0.10.20.70.3-0.3-0.6-0.2-0.8-0.8-0.3-0.4-0.6-0.0-0.10.2-0.2
Reaction time omissions0.81.12.9-1.61.61.3-1.71.10.80.9-0.8-0.1-0.40.30.30.5
Reaction time false alarm rate0.30.41.70.5-0.5-0.71.30.0-0.1-0.80.80.60.50.10.2-0.3
Reaction time premature initiation rate1.72.46.2-1.81.81.9-0.62.52.21.50.71.70.51.30.91.2
Reaction time premature initiations2.54.49.5-2.32.32.3-0.92.93.12.41.12.30.91.91.52.0
Std. dev. reaction times0.40.83.0-1.31.31.0-1.70.50.30.8-0.9-0.6-0.60.00.20.3
Reaction time trials completed0.30.62.1-0.60.60.5-0.20.71.51.20.80.80.30.60.61.0
Reaction time trials AUC0.20.51.7-0.40.40.3-0.00.61.31.00.80.80.20.50.50.8
Run reversals in cocaine runway, females0.90.92.0-0.50.50.6-0.21.1-0.6-1.0-1.2-0.6-1.2-1.1-1.4-1.4
Run reversals in cocaine runway, males0.90.92.90.5-0.5-0.61.1-0.50.90.81.71.21.10.80.91.1
Latency to leave start box in cocaine runway0.91.02.00.2-0.2-0.2-0.4-0.2-1.2-1.3-1.3-1.4-1.1-1.3-1.3-1.4
Latency to leave start box in cocaine runway, F0.30.31.00.2-0.20.0-0.30.0-0.8-1.0-0.9-0.8-0.2-0.3-0.5-0.9
Latency to leave start box in cocaine runway, M0.70.72.1-0.20.2-0.1-0.3-0.1-0.5-0.4-0.9-0.9-1.5-1.5-1.3-0.9
Std. dev. time between licks in bursts0.40.61.90.1-0.1-0.21.20.60.90.11.41.40.70.50.50.5
Total sessions with >9 infusions0.91.12.60.2-0.2-0.1-0.5-0.3-1.0-0.8-1.1-1.4-1.5-1.6-1.6-1.3
Short access day 1 total inactive lever presses1.41.83.81.7-1.7-2.01.6-1.9-1.5-1.50.3-0.6-0.2-1.1-0.7-1.1
Short access day 10 total inactive lever presses0.20.41.50.8-0.8-0.91.2-0.5-0.5-0.80.50.40.70.20.5-0.2
Short access day 1 total infusions1.92.54.01.5-1.5-1.50.7-1.6-2.0-1.9-0.8-1.6-1.2-2.0-1.9-1.9
Short access day 10 total infusions3.34.28.30.8-0.8-0.8-0.6-1.1-2.4-2.1-2.0-2.7-2.4-2.9-2.8-2.6
Short access total infusions2.02.66.10.9-0.9-0.8-0.0-0.9-1.7-1.6-1.3-1.9-1.9-2.5-2.3-2.1
Short access day 1 locomotion1.41.73.11.5-1.5-1.50.8-1.5-1.8-1.6-0.3-1.2-0.5-1.3-1.2-1.3
Short access day 10 total locomotion1.12.03.61.2-1.2-1.20.0-1.5-1.9-1.6-1.0-1.8-1.2-1.7-1.5-1.6
Short access total locomotion1.82.23.81.5-1.5-1.40.4-1.6-2.0-1.7-0.8-1.7-1.1-1.7-1.6-1.6
One hour access (0.3 mA shock)3.84.39.73.0-3.0-3.02.1-3.1-2.2-2.00.6-1.1-0.1-1.4-1.0-1.2
Compulsive drug intake2.83.36.4-1.61.61.50.32.32.41.61.12.51.62.31.91.7
One hour access (shock baseline)3.96.014.83.3-3.3-3.21.5-3.9-3.0-2.3-0.0-2.2-0.7-2.1-1.6-1.7
Social response proportion0.40.51.3-1.11.10.8-1.10.80.30.8-0.4-0.2-0.30.10.20.3
Social responses0.30.40.7-0.60.60.5-0.20.70.80.70.60.60.40.60.70.8
Social time0.40.61.5-0.60.60.4-0.20.81.20.90.80.90.40.70.80.9
Soleus weight2.16.214.93.9-3.9-3.73.3-3.3-2.2-2.51.2-0.40.4-1.0-0.6-1.2
Bone: stiffness2.03.28.5-2.22.22.1-2.91.40.00.6-2.3-1.6-2.2-1.2-1.5-0.7
Tibialis anterior weight5.518.639.6-6.36.36.3-5.35.64.85.1-0.91.2-1.41.20.82.8
Time to tail flick, vehicle, before self-admin0.50.51.5-0.30.30.5-0.90.3-0.3-0.1-0.8-0.9-1.2-0.9-0.9-0.7
Time to tail flick, vehicle, after self-admin1.31.73.7-0.60.60.8-1.11.1-0.6-0.9-1.6-1.3-1.9-1.7-1.9-1.6
Time to tail flick, test, before self-admin2.22.34.81.5-1.5-1.51.1-1.2-2.0-2.2-0.5-1.2-0.8-1.6-1.6-2.0
Time to tail flick, test, after self-admin0.10.10.3-0.20.20.2-0.5-0.10.30.50.0-0.2-0.1-0.1-0.00.3
Delta time to tail flick, vehicle, before/after SA0.40.40.7-0.60.60.6-0.50.9-0.1-0.4-0.8-0.3-0.7-0.5-0.8-0.7
Delta time to tail flick, test, before/after SA3.43.58.0-1.41.41.5-1.00.92.42.81.21.61.42.12.22.7
Tibia length0.71.96.3-1.81.81.9-2.50.71.02.0-0.8-0.7-0.90.0-0.21.0
Ambulatory time before self-admin0.60.92.8-0.80.80.7-1.70.1-0.60.1-1.5-1.4-1.1-0.8-0.9-0.5
Ambulatory time after self-admin0.30.31.00.3-0.3-0.4-0.2-0.7-1.0-0.7-0.7-0.80.3-0.0-0.1-0.5
Bone: tissue strength0.10.10.2-0.10.1-0.1-0.3-0.3-0.3-0.2-0.4-0.4-0.2-0.3-0.2-0.2
Total heroin consumption2.93.47.3-2.72.72.7-2.52.51.71.9-1.10.3-0.10.90.61.0
Bone: trabecular number1.11.93.9-1.21.21.1-2.00.6-0.7-0.2-2.0-1.7-1.8-1.3-1.6-1.1
Bone: trabecular spacing0.50.71.90.9-0.9-0.91.4-0.30.2-0.31.00.91.10.70.80.2
Bone: trabecular thickness0.60.81.60.5-0.5-0.70.1-0.7-1.3-1.2-0.8-1.1-0.7-0.9-1.0-1.1
Bone: trabecular tissue density1.92.86.92.6-2.6-2.52.2-2.5-1.2-1.21.1-0.00.9-0.10.2-0.2
Water consumed over 24 hours1.01.32.4-1.11.11.3-0.71.31.21.10.21.01.11.61.41.2
Number of responses in last shaping day0.20.20.60.1-0.1-0.10.50.10.50.30.60.80.60.70.60.5