Hub : Genes

Tmem216

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Tmem216 0.13 0.07 1.6e-03 0.01 0.01 0.01 0 5.0e-02 7.1e-02 7.4e-03 2.1e-01
2 IC mRNA stability Tmem216 0.12 0.07 6.8e-04 0.04 0.07 0.04 0.04 8.6e-03 9.6e-04 7.9e-03 6.2e-03
3 Liver gene expression Tmem216 0.15 0.07 2.3e-06 0.04 0.05 0.05 0.05 3.9e-05 6.0e-06 5.4e-06 4.1e-06
4 Adipose mRNA stability Tmem216 0.16 0.09 4.6e-03 0.02 0.01 0.01 0.02 1.5e-03 3.4e-02 9.8e-03 5.4e-03
5 NAcc isoform ratio XM_006231045.5 0.07 0.06 1.7e-03 0.02 0.01 0.01 0.01 2.3e-04 2.3e-03 1.9e-03 7.0e-03
6 NAcc mRNA stability Tmem216 0.03 0.02 1.6e-04 0.03 0.03 0.03 0.03 1.1e-05 7.4e-05 9.3e-05 3.9e-05
7 PL mRNA stability Tmem216 0.06 0.03 3.2e-06 0.06 0.05 0.04 0.05 1.1e-06 1.5e-06 1.5e-05 4.1e-06
8 pVTA mRNA stability Tmem216 0.04 0.03 2.0e-03 0.02 0.03 0.02 0.02 8.5e-03 1.9e-03 1.1e-02 4.5e-03
9 NAcc isoform ratio NM_001271039.1 0.05 0.05 6.0e-03 0.01 0.01 0.01 0.01 2.6e-02 1.1e-02 4.5e-03 2.5e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density0.10.20.50.40.30.70.4-0.40.30.30.60.3
Area under the delay curve0.30.42.1-1.5-0.30.1-0.60.50.10.10.50.7
BMI with tail3.211.019.10.83.14.33.3-3.23.43.44.42.8
BMI without tail0.82.44.0-1.41.31.51.4-1.51.71.72.01.4
Body weight3.214.121.61.03.64.24.2-4.23.93.94.73.0
Weight adjusted by age2.03.13.81.71.91.91.7-1.71.71.71.71.7
Bone surface0.81.53.71.40.71.50.9-0.90.80.81.51.9
Bone volume0.50.92.71.60.31.10.8-0.80.20.21.01.5
Breakpoint value in progressive ratio session2.12.54.82.21.91.31.7-1.61.71.71.00.5
Number of licking bursts0.10.20.4-0.40.30.30.5-0.60.20.20.50.1
Context. condit. distance diff. score0.10.10.2-0.30.20.30.3-0.40.20.20.50.2
Locomotion velocity, session 10.20.20.9-1.00.30.2-0.30.30.70.7-0.0-0.1
Locomotion distance, session 11.11.32.2-0.51.51.11.1-1.11.51.51.0-0.9
Locomotion velocity, session 21.92.33.50.41.91.91.3-1.31.81.81.7-0.2
Locomotion distance, session 21.41.92.7-1.41.50.91.3-1.41.61.60.9-1.6
Locomotion velocity, session 30.91.02.90.40.81.50.8-0.80.60.61.71.0
Locomotion distance, session 30.40.40.6-0.3-0.7-0.4-0.80.8-0.7-0.7-0.30.7
Stereotopy head waving bouts, day 30.50.62.7-1.70.30.70.1-0.00.60.60.9-0.5
Stereotopy head waving duration, day 30.50.61.9-1.40.50.90.4-0.30.80.81.1-0.2
Locomotion velocity, session 70.20.20.5-0.6-0.20.3-0.70.5-0.2-0.20.30.4
Locomotion distance, session 70.30.42.9-1.7-0.20.1-0.60.50.00.00.40.2
Stereotopy head waving bouts, day 70.40.41.21.10.20.60.3-0.30.70.70.40.9
Stereotopy head waving duration, day 70.81.01.41.00.81.01.0-0.91.21.20.90.9
Locomotion velocity, session 80.30.42.5-1.6-0.3-0.50.4-0.4-0.2-0.2-0.40.3
Locomotion distance, session 80.20.31.3-1.10.30.50.3-0.40.50.50.6-0.4
Degree of sensitization distance1.11.12.1-0.80.91.30.8-0.91.21.21.50.1
Degree of sensitization stereotypy1.41.64.22.10.81.11.0-1.01.21.20.91.6
Conditioned locomotion0.50.61.3-0.90.80.5-0.10.01.11.10.9-0.2
Cocaine response after cond. corrected0.40.52.7-1.70.30.10.1-0.10.70.70.30.5
Cocaine response after cond. not corrected0.00.10.2-0.20.20.2-0.20.10.20.20.10.5
Cocaine response before conditioning1.61.914.63.8-0.10.3-0.20.1-0.9-0.9-0.60.1
Saline control response1.11.52.80.21.51.01.7-1.71.41.41.0-0.0
Bone: connectivity density0.71.12.10.41.01.40.8-0.81.21.21.40.8
Bone: cortical apparent density0.20.30.90.90.60.30.1-0.10.60.6-0.1-0.5
Bone: cortical area0.20.32.01.40.30.40.1-0.3-0.1-0.10.2-0.6
Bone: cortical porosity0.10.10.1-0.30.2-0.40.3-0.30.10.1-0.2-0.3
Bone: cortical porosity0.10.10.4-0.60.4-0.20.3-0.30.30.3-0.0-0.2
Bone: cortical thickness0.91.64.30.71.70.51.0-1.21.31.30.2-2.1
Bone: cortical thickness0.30.41.70.70.2-0.2-0.70.60.10.1-0.3-1.3
Bone: cortical tissue density0.30.41.01.00.80.40.3-0.30.80.80.1-0.4
Condit. Reinf. active minus inactive responses1.61.72.81.31.61.21.4-1.31.71.70.8-0.2
Condit. Reinf. active-inactive response ratio1.11.22.50.91.40.61.1-1.01.61.60.2-0.6
Condit. Reinf. active responses1.72.13.41.81.71.61.3-1.31.61.61.1-0.6
Condit. Reinf. inactive responses0.30.41.61.20.40.90.3-0.40.10.10.7-0.4
Incentive salience index mean1.11.31.91.41.31.30.9-0.91.41.40.9-0.6
Condit. Reinf. lever presses0.30.41.91.40.40.90.0-0.10.30.30.6-0.3
Condit. Reinf. active minus inactive responses0.20.32.31.50.30.0-0.10.10.10.1-0.2-0.2
Condit. Reinf. active-inactive response ratio0.70.82.41.40.30.90.6-0.70.40.41.01.5
Condit. Reinf. active responses0.20.32.21.50.40.2-0.0-0.00.30.3-0.2-0.1
Condit. Reinf. inactive responses0.50.71.80.6-0.4-0.9-0.80.8-0.5-0.5-1.3-1.1
Condit. Reinf. lever presses1.31.85.82.41.01.51.3-1.30.70.71.11.3
Condit. Reinf. lever reinforcers received0.40.63.41.80.70.50.5-0.50.60.60.10.2
Conditioned reinforcement - actives0.50.85.52.4-0.2-0.1-0.40.4-0.6-0.6-0.60.6
Conditioned reinforcement - inactives0.40.64.12.00.20.80.3-0.4-0.1-0.10.60.3
Conditioned locomotion0.81.01.8-0.5-1.3-0.5-1.31.3-1.3-1.3-0.5-0.2
Patch foraging indifference point 0 sec0.20.30.5-0.50.70.50.7-0.70.30.30.5-0.4
Patch foraging indifference point AUC0.71.02.11.51.20.70.9-0.91.01.00.3-1.3
Delay disc. indifference point, 0s delay0.50.62.2-1.5-0.30.1-0.20.30.00.00.81.4
Delay disc. indifference point, 16s delay0.10.10.50.70.10.4-0.10.10.30.30.30.3
Delay disc. indifference point, 2s delay0.60.61.8-0.5-1.1-0.2-0.80.7-0.7-0.70.01.4
Delay disc. indifference point, 24s delay0.20.21.0-1.0-0.1-0.1-0.50.40.30.30.1-0.6
Delay disc. indifference point, 4s delay0.60.75.1-2.3-0.10.2-0.20.00.20.20.80.2
Delay disc. indifference point, 8s delay1.31.59.3-3.0-0.9-0.8-1.21.0-0.3-0.3-0.20.6
Indifference point function ln k1.01.72.8-1.6-1.7-1.0-1.41.3-1.4-1.4-0.51.0
Indifference point function log k1.01.72.8-1.6-1.7-1.0-1.41.3-1.4-1.4-0.51.0
Patch foraging total patch changes 0 sec0.20.30.7-0.40.80.30.6-0.60.40.40.3-0.8
Patch foraging total patch changes 12 sec3.24.28.01.02.82.02.3-2.42.32.31.7-0.9
Patch foraging total patch changes 18 sec0.40.61.10.20.90.11.0-1.10.70.70.1-1.0
Patch foraging total patch changes 24 sec3.35.78.60.72.92.32.8-2.82.62.62.5-1.2
Patch foraging total patch changes 6 sec0.50.71.60.20.90.91.2-1.20.60.60.8-0.2
Patch foraging time to switch 0 sec0.51.03.81.30.31.10.5-0.50.40.41.11.9
Patch foraging water rate 0 sec0.71.43.3-0.3-0.8-1.2-1.01.0-1.1-1.1-1.5-1.8
Patch foraging water rate 12 sec0.71.52.8-1.7-1.3-1.4-0.80.8-1.1-1.1-1.2-1.2
Patch foraging water rate 18 sec0.71.12.1-1.5-0.9-0.9-1.11.0-0.9-0.9-0.7-1.3
Patch foraging water rate 24 sec0.71.01.5-1.0-1.2-1.2-0.90.9-1.2-1.2-1.1-0.1
Patch foraging water rate 6 sec1.11.54.0-2.0-1.1-1.5-0.90.9-1.0-1.0-1.2-1.2
Seeking ratio, delayed vs. immediate footshock0.50.72.1-0.60.60.60.8-0.80.60.60.8-1.4
Distance traveled before self-admin2.12.77.62.71.31.61.7-1.90.80.81.41.7
Distance traveled after self-admin0.40.51.61.30.90.50.8-1.00.40.40.4-0.1
Extensor digitorum longus weight4.517.624.61.05.04.74.4-4.54.94.94.80.5
Bone: elastic displacement0.80.92.4-1.5-0.4-1.1-0.70.6-0.2-0.2-1.1-1.4
Bone: elastic work0.60.81.2-0.91.00.00.9-0.91.11.10.1-1.0
Bone: endosteal estimation0.61.42.70.2-1.6-0.1-1.11.2-1.5-1.50.31.7
Bone: endosteal perimeter1.42.98.21.1-2.1-0.1-1.31.4-2.0-2.00.12.9
Epididymis fat weight0.20.71.90.6-1.40.10.0-0.1-1.3-1.30.11.1
Delta time in closed arm before/after self-admin3.33.15.3-2.31.90.91.8-2.01.91.91.5-1.0
Delta time in open arm before/after self-admin2.22.19.63.11.51.60.6-0.61.21.21.1-0.1
Diff in mean of infusions in LGA sessions1.72.13.90.92.01.41.6-1.51.71.71.30.6
Delay discount exponential model param0.30.42.01.40.3-0.10.6-0.5-0.1-0.1-0.5-0.6
Extinction: sum of active levers before priming2.02.23.90.61.72.01.3-1.21.71.71.80.3
Active lever presses in extinction session 62.12.07.42.71.31.61.3-1.11.01.01.01.0
Bone: final force0.50.81.91.40.91.10.8-0.80.80.80.90.2
Bone: final moment0.50.81.61.31.01.10.8-0.80.80.80.90.0
Food consumed during 24 hour testing period0.40.51.00.7-0.7-0.8-0.60.6-0.9-0.9-1.0-0.0
Glucose1.21.85.7-2.4-1.8-1.0-0.50.6-1.5-1.5-0.71.1
Heart weight0.91.37.9-2.8-0.60.1-0.60.60.10.11.01.4
Delay discount hyperbolic model param0.40.41.91.40.5-0.00.8-0.60.10.1-0.4-0.8
Intermittent access intake day 1-15 change0.91.92.51.5-1.3-1.1-1.01.0-1.6-1.6-1.5-1.5
Intermittent access intake escalation0.91.93.11.8-1.3-1.1-1.01.0-1.6-1.6-1.6-1.3
Intermittent access intake escalation 20.91.04.82.2-0.6-0.4-0.40.4-0.9-0.9-0.8-1.3
Intermitt. access day 1 inactive lever presses0.10.31.71.3-0.3-0.2-0.50.5-0.3-0.3-0.30.1
Intermitt. access day 15 inactive lever presses1.12.26.92.61.02.01.4-1.50.60.61.7-0.2
Intermitt. access escalation Index1.31.83.9-1.9-1.0-1.0-1.41.5-0.9-0.9-0.8-2.0
Intermittent access day 1 total infusions0.40.62.2-0.4-0.21.40.2-0.20.00.01.50.8
Intermittent access day 15 total infusions1.11.63.50.6-1.8-0.4-1.31.2-1.9-1.9-0.7-0.9
Intermittent access terminal intake (last 3 days)0.40.52.21.5-0.70.8-0.1-0.0-0.8-0.80.4-0.3
Intermittent access total infusions0.30.40.70.3-0.80.8-0.40.3-0.8-0.80.60.1
Intermittent access day 1 locomotion0.40.51.90.10.31.40.2-0.30.30.31.40.5
Intermittent access day 15 total locomotion0.71.35.92.40.31.60.6-0.70.20.21.30.4
Intermittent access total locomotion1.11.34.42.10.02.00.3-0.4-0.1-0.11.60.4
Intermittent access standard deviation0.10.31.41.2-0.3-0.20.0-0.0-0.6-0.6-0.50.1
Left kidney weight0.20.83.1-0.6-1.20.1-0.30.4-0.8-0.80.61.8
Right kidney weight0.00.20.5-0.7-0.70.1-0.20.2-0.5-0.50.40.4
Cocaine induced anxiety0.20.32.21.50.30.1-0.00.10.10.1-0.10.4
Post-drug Anxiety0.40.51.31.10.40.60.6-0.60.40.40.51.0
Baseline Anxiety0.30.41.6-1.30.30.40.5-0.60.40.40.7-0.1
Tail length0.20.61.3-0.70.8-0.31.1-1.10.80.80.1-0.5
Length with tail1.04.28.71.02.01.52.9-3.02.02.02.01.1
Length without tail2.27.213.50.92.82.53.7-3.62.82.82.61.0
Times rat made contact with spout0.30.40.8-0.70.7-0.20.6-0.60.70.7-0.1-0.9
Lifetime Intake0.20.20.6-0.4-0.50.7-0.30.2-0.5-0.50.70.2
Liver weight, left0.50.81.4-1.1-1.0-1.2-0.70.5-0.8-0.8-1.1-0.8
Liver weight, right1.01.74.1-2.0-1.6-1.4-0.60.6-1.4-1.4-1.3-0.0
Locomotor activity1.32.17.7-2.8-0.9-1.8-0.40.3-0.9-0.9-1.5-1.7
Locomotor testing distance1.01.76.2-2.5-0.8-1.5-0.60.6-0.7-0.7-1.4-1.6
Locomotor testing rearing0.50.92.0-1.2-0.8-1.3-0.40.4-0.8-0.8-1.4-1.0
Locomotion in novel chamber0.91.22.90.3-1.7-0.8-1.31.0-1.3-1.3-1.00.4
Locomotion in novel chamber post-restriction0.61.11.8-0.3-1.2-1.3-1.21.2-1.0-1.0-1.2-0.4
Fecal boli incidents, locomotor time 10.81.28.62.90.30.20.8-0.8-0.1-0.1-0.10.8
Change in fecal boli incidents, locomotor task2.82.89.9-3.2-1.9-1.4-1.51.6-1.4-1.4-0.80.5
Time >=10cm from walls, locomotor time 10.91.03.82.0-0.90.1-0.91.0-0.8-0.8-0.21.0
Bouts of movement, locomotor time 12.32.66.52.61.90.32.2-2.21.01.00.2-0.9
Total resting periods, locomotor time 11.92.17.92.81.50.32.0-1.90.60.60.1-0.6
Rest time, locomotor task time 10.60.71.80.2-0.8-1.0-0.20.2-1.4-1.4-0.8-0.3
Distance moved, locomotor task time 10.30.41.3-0.3-0.10.7-0.70.60.60.60.41.2
Vertical activity count, locomotor time 10.81.95.5-1.5-1.5-0.9-2.32.2-0.5-0.5-1.10.0
Time >=10cm from walls, locomotor time 20.50.73.92.0-0.4-0.2-0.80.8-0.4-0.4-0.50.3
Bouts of movement, locomotor time 23.25.28.72.22.92.02.7-2.72.32.31.8-1.0
Total resting periods, locomotor time 22.64.67.92.02.81.82.5-2.52.12.11.7-1.3
Rest time, locomotor task time 20.30.41.2-1.1-0.6-0.7-0.10.2-0.7-0.7-0.5-0.7
Distance moved, locomotor task time 20.40.41.40.6-0.4-0.2-1.10.8-0.1-0.1-0.51.2
Vertical activity count, locomotor time 21.31.83.7-1.8-1.2-1.3-1.91.7-0.7-0.7-1.40.2
Light reinforcement 10.20.41.11.0-0.4-0.6-0.30.3-0.6-0.6-0.9-0.4
Light reinforcement 20.60.93.71.9-0.9-0.1-0.60.7-1.1-1.1-0.20.7
Bone: marrow area0.71.63.0-0.0-1.7-0.2-1.21.3-1.6-1.60.21.6
Bone: maximum diameter0.20.42.71.6-0.10.50.0-0.1-0.4-0.40.50.4
Bone: maximum force1.11.93.61.91.21.81.0-1.11.11.11.80.9
Bone: maximum moment1.01.83.21.81.31.81.1-1.11.11.11.80.7
Mean time between licks in bursts0.61.43.0-1.71.10.7-0.10.11.51.50.7-1.7
Mean num. licks in bursts0.20.31.2-0.30.0-0.7-0.30.40.10.1-0.8-1.1
Cd content in liver1.01.11.70.2-1.3-0.9-1.21.2-0.9-0.9-1.01.2
Co content in liver1.11.32.2-1.1-0.9-1.4-1.21.2-0.8-0.8-1.3-1.5
Cu content in liver0.20.31.2-0.8-0.2-0.5-0.30.4-0.2-0.2-0.3-1.1
Fe content in liver0.00.00.2-0.4-0.00.00.10.00.20.20.20.2
K content in liver0.10.10.40.70.30.60.0-0.00.00.00.5-0.2
Mg content in liver0.10.10.5-0.7-0.10.00.2-0.2-0.1-0.10.0-0.6
Mn content in liver1.51.72.91.01.71.70.9-0.91.51.51.60.2
Na content in liver0.10.10.90.90.20.30.0-0.00.20.2-0.1-0.1
Rb content in liver1.92.22.7-1.5-1.6-1.6-1.51.5-1.4-1.4-1.5-1.3
Se content in liver0.40.51.81.40.50.80.2-0.20.40.40.90.9
Sr content in liver4.23.66.3-0.42.31.82.0-1.92.52.51.8-0.2
Zn content in liver1.82.03.40.31.91.41.2-1.21.61.61.2-1.5
Bone: minimum diameter0.40.71.50.4-1.00.1-1.11.0-1.2-1.20.1-0.2
Time in familiar zone, hab. session 10.30.31.00.90.40.30.6-0.60.00.00.1-1.0
Time in novel zone, hab. session 11.11.11.6-0.8-1.3-1.2-1.01.0-1.0-1.0-1.10.7
Total zone transitions, hab. session 10.20.20.5-0.60.60.20.4-0.30.70.70.1-0.3
Total locomotion distance, hab. session 10.20.30.60.20.50.70.4-0.40.70.70.70.3
Locomotion velocity, hab. session 10.60.81.60.01.01.00.8-0.81.31.31.00.1
Time in familiar zone, hab. session 20.90.91.8-0.1-1.1-1.2-0.80.9-1.1-1.1-1.30.1
Time in novel zone, hab. session 20.70.71.1-0.11.01.00.6-0.81.01.01.0-0.4
Total zone transitions, hab. session 20.50.61.30.01.00.60.7-0.71.01.00.3-1.1
Total locomotion distance, hab. session 20.40.50.80.00.80.70.7-0.60.90.90.5-0.9
Locomotion velocity, hab. session 20.20.30.50.10.60.60.5-0.40.70.70.5-0.7
Novel to familiar place preference ratio1.01.12.2-0.11.11.20.9-1.01.21.21.50.6
Novelty place preference0.70.81.7-0.20.81.00.8-0.80.90.91.30.7
Time in novel zone, NPP test1.21.32.4-0.31.11.21.2-1.21.21.21.60.9
Total zone transitions, NPP test0.71.01.7-0.81.30.80.9-0.91.31.30.4-1.1
Total locomotion distance, NPP test0.30.52.0-1.00.50.20.1-0.20.60.60.1-1.4
Locomotion velocity, NPP test0.40.53.1-1.10.1-0.2-0.40.40.20.2-0.3-1.8
Intraocular pressure0.00.00.10.10.2-0.20.2-0.20.10.1-0.20.1
Delta distance traveled before/after self-admin1.11.26.4-2.5-0.2-0.9-0.70.70.00.0-0.6-1.5
Delta ambulatory time before/after self-admin0.70.93.1-1.8-0.4-1.1-0.91.0-0.3-0.3-0.9-0.9
Parametrial fat weight1.22.86.30.0-2.5-0.6-1.92.0-2.2-2.2-0.21.2
Pavlov. Cond. lever latency0.20.31.4-1.2-0.5-0.7-0.10.2-0.4-0.4-0.30.5
Pavlov. Cond. magazine entry latency1.31.77.22.70.81.40.9-0.80.90.90.91.1
Pavlov. Cond. change in total contacts0.60.74.82.20.50.70.1-0.10.40.40.2-0.5
Pavlov. Cond. index score0.50.63.61.90.50.70.5-0.50.60.60.20.1
Pavlov. Cond. latency score0.40.53.31.80.30.60.3-0.30.30.30.10.1
Pavlov. Cond. lever contacts0.20.21.31.20.10.4-0.20.10.10.10.0-0.3
Pavlov. Cond. magazine entry number0.91.26.2-2.5-0.8-1.0-0.70.6-0.9-0.9-0.5-0.5
Pavlov. Cond. intertrial magazine entries0.50.64.1-0.30.2-0.50.1-0.2-0.3-0.3-0.9-2.0
Pavlov. Cond. lever-magazine prob. diff.0.60.73.51.90.70.80.5-0.50.70.70.3-0.1
Pavlov. Cond. response bias0.81.05.02.20.81.00.5-0.50.90.90.50.1
Pavlov. Cond. lever latency1.72.35.9-2.4-1.5-1.7-1.51.5-1.2-1.2-1.3-0.5
Pavlov. Cond. magazine entry latency7.08.417.44.23.23.13.0-3.02.62.62.50.6
Pavlov. Cond. change in total contacts2.84.518.94.31.82.12.1-2.01.21.21.31.0
Pavlov. Cond. index score5.57.419.04.42.62.92.9-2.82.12.12.31.4
Pavlov. Cond. latency score5.47.118.24.32.52.82.9-2.82.02.02.31.4
Pavlov. Cond. lever contacts1.92.77.52.71.61.71.8-1.81.21.21.30.4
Pavlov. Cond. magazine entry number10.613.023.5-4.9-3.9-3.8-3.93.8-3.3-3.3-3.3-1.5
Pavlov. Cond. intertrial magazine entries1.62.43.8-1.7-1.9-1.8-1.31.3-1.5-1.5-1.80.7
Pavlov. Cond. lever-magazine prob. diff.6.07.920.64.52.72.93.0-3.02.22.22.41.4
Pavlov. Cond. response bias3.54.810.63.32.32.42.2-2.11.91.92.00.5
Time in closed arm before self-admin0.81.05.02.2-0.7-0.0-0.40.3-0.9-0.9-0.31.3
Time in closed arm after self-admin0.40.50.8-0.9-0.7-0.9-0.1-0.2-0.8-0.8-0.6-0.5
Time in open arm before self-admin4.04.426.2-5.1-1.1-1.7-1.11.3-0.5-0.5-1.2-2.1
Time in open arm after self-admin0.60.62.3-1.20.60.2-0.30.40.80.80.1-1.5
Bone: periosteal estimation0.30.61.61.3-0.70.4-0.50.5-0.9-0.90.50.7
Bone: periosteal perimeter0.20.41.51.2-0.50.2-0.10.1-0.7-0.70.10.9
Bone: post-yield work0.81.24.51.5-1.00.6-0.30.4-1.0-1.00.82.1
Progressive ratio test 1 active lever presses0.10.10.1-0.3-0.30.2-0.20.1-0.3-0.30.30.3
Progressive ratio test 1 breakpoint0.10.10.2-0.2-0.20.3-0.20.1-0.2-0.20.30.5
Progressive ratio test 1 inactive lever presses1.72.44.31.41.62.11.5-1.51.41.42.00.5
Progressive ratio test 2 active lever presses0.30.30.70.8-0.60.3-0.40.3-0.8-0.80.1-0.3
Progressive ratio test 2 breakpoint0.30.30.80.9-0.60.4-0.30.2-0.8-0.80.2-0.3
Progressive ratio test 2 inactive lever presses0.30.52.61.6-0.20.7-0.0-0.1-0.6-0.60.4-0.7
Incentive Sensitization - Responses0.71.03.11.80.81.50.7-0.60.60.61.3-0.1
Incentive Sensitization - Breakpoint0.70.93.11.80.71.50.6-0.60.50.51.3-0.1
Sum of active levers in priming session hrs 5-60.80.85.12.30.90.60.5-0.40.40.40.0-0.4
Progressive ratio0.30.51.61.3-0.10.70.10.10.20.20.81.1
Food seeking constrained by brief footshock0.10.10.4-0.2-0.1-0.4-0.50.70.10.1-0.2-0.6
Seeking ratio, punishment vs. effort0.71.05.5-2.30.2-0.5-0.10.00.20.2-0.3-1.7
Retroperitoneal fat weight1.46.013.1-2.2-3.6-2.0-2.22.3-3.2-3.2-1.40.0
Reaction time number correct0.51.04.20.30.2-0.21.6-1.50.30.3-0.02.0
Reaction time mean minus median0.61.66.62.60.70.80.6-0.60.70.70.32.1
Reaction time mean minus median AUC0.41.04.92.20.40.10.6-0.60.50.5-0.41.6
Reaction time num false alarms1.31.99.6-3.1-0.4-1.3-0.60.5-0.3-0.3-0.8-2.0
Reaction time num false alarms AUC1.32.011.8-3.4-0.1-1.1-0.50.5-0.1-0.1-0.7-1.9
Reaction time trials correct on left0.51.04.20.30.2-0.21.6-1.50.30.3-0.02.0
Reaction time trials on left0.61.14.40.40.2-0.21.6-1.60.30.3-0.02.1
Reaction time mean0.50.85.92.40.20.4-0.30.30.40.4-0.20.8
Reaction time mean AUC0.60.96.72.6-0.00.3-0.40.50.10.1-0.40.7
Median of all reaction times0.40.64.62.20.20.5-0.30.40.40.4-0.00.4
Reaction time omissions0.40.62.31.50.40.40.7-0.60.40.4-0.01.3
Reaction time false alarm rate1.72.39.2-3.0-0.3-0.8-1.31.2-0.3-0.3-0.6-2.7
Reaction time premature initiation rate1.92.65.60.91.52.41.1-1.21.51.52.31.4
Reaction time premature initiations1.93.44.41.11.72.02.1-2.11.61.62.02.0
Std. dev. reaction times0.40.74.12.0-0.0-0.1-0.20.30.10.1-0.71.3
Reaction time trials completed0.61.14.40.40.2-0.21.6-1.60.30.3-0.02.1
Reaction time trials AUC0.51.03.80.10.1-0.21.6-1.60.20.2-0.02.0
Run reversals in cocaine runway, females0.60.62.4-1.60.00.80.2-0.40.40.40.91.0
Run reversals in cocaine runway, males2.52.54.1-1.6-1.4-1.4-2.02.0-1.5-1.5-1.5-1.2
Latency to leave start box in cocaine runway0.60.71.4-0.1-1.2-0.2-0.90.8-1.1-1.1-0.00.9
Latency to leave start box in cocaine runway, F0.10.10.2-0.1-0.00.30.1-0.2-0.4-0.40.50.1
Latency to leave start box in cocaine runway, M2.12.03.80.0-1.9-1.1-1.61.6-1.5-1.5-0.91.5
Std. dev. time between licks in bursts0.50.71.9-1.4-0.4-0.6-1.01.0-0.3-0.3-0.4-1.2
Total sessions with >9 infusions0.20.21.0-0.6-0.30.2-0.50.4-0.2-0.20.31.0
Short access day 1 total inactive lever presses0.10.10.6-0.8-0.10.2-0.20.1-0.1-0.10.40.1
Short access day 10 total inactive lever presses0.10.20.5-0.2-0.1-0.5-0.60.60.10.1-0.5-0.7
Short access day 1 total infusions0.40.51.3-1.1-0.9-0.5-0.70.7-0.8-0.8-0.3-0.0
Short access day 10 total infusions0.30.31.2-0.3-0.11.1-0.20.10.00.01.10.7
Short access total infusions0.30.31.7-1.3-0.40.5-0.30.2-0.1-0.10.70.5
Short access day 1 locomotion0.10.10.30.2-0.10.1-0.30.3-0.5-0.50.0-0.5
Short access day 10 total locomotion0.71.33.21.40.81.80.6-0.60.90.91.71.1
Short access total locomotion0.40.51.50.80.41.20.2-0.30.30.31.20.5
One hour access (0.3 mA shock)0.30.41.00.2-0.70.2-0.50.4-0.9-0.90.2-1.0
Compulsive drug intake0.80.91.3-1.11.10.11.1-1.11.11.10.40.7
One hour access (shock baseline)1.62.54.70.7-2.0-0.7-1.71.6-2.2-2.2-0.9-1.3
Social response proportion0.50.61.1-0.1-0.9-0.7-0.70.8-1.1-1.1-0.70.5
Social responses0.50.71.3-0.2-0.5-1.1-0.60.6-1.0-1.0-1.1-0.8
Social time0.20.30.9-0.9-0.0-1.0-0.20.20.00.0-0.9-0.2
Soleus weight2.26.49.0-1.4-2.7-2.6-2.62.5-3.0-3.0-2.8-1.6
Bone: stiffness0.40.64.22.00.20.70.2-0.2-0.0-0.00.60.5
Tibialis anterior weight5.719.329.30.75.44.44.9-4.95.45.44.20.0
Time to tail flick, vehicle, before self-admin0.40.42.00.30.10.8-0.0-0.10.00.00.91.4
Time to tail flick, vehicle, after self-admin1.01.32.80.20.81.11.4-1.21.01.01.41.7
Time to tail flick, test, before self-admin0.50.53.1-1.8-0.00.40.5-0.50.20.20.80.3
Time to tail flick, test, after self-admin0.10.10.80.9-0.1-0.1-0.30.1-0.3-0.3-0.40.2
Delta time to tail flick, vehicle, before/after SA0.80.72.00.30.90.51.4-1.21.01.00.60.1
Delta time to tail flick, test, before/after SA0.90.95.92.40.5-0.1-0.30.30.00.0-0.7-1.1
Tibia length1.02.78.52.91.21.71.6-1.60.80.81.41.7
Ambulatory time before self-admin1.42.09.43.11.01.41.1-1.40.60.60.91.0
Ambulatory time after self-admin0.30.42.41.60.40.50.4-0.6-0.2-0.20.30.2
Bone: tissue strength0.80.81.0-0.4-0.9-1.0-1.01.0-0.9-0.9-1.0-0.7
Total heroin consumption2.83.36.31.42.51.72.0-1.72.22.21.40.0
Bone: trabecular number0.61.02.10.60.91.40.8-0.81.11.11.40.6
Bone: trabecular spacing0.60.82.5-0.4-0.3-1.3-0.40.4-0.5-0.5-1.4-1.6
Bone: trabecular thickness0.20.30.60.8-0.6-0.10.1-0.1-0.7-0.7-0.30.6
Bone: trabecular tissue density2.94.26.0-1.1-2.3-2.4-2.12.1-2.3-2.3-2.4-0.7
Water consumed over 24 hours0.20.20.60.20.60.30.7-0.80.30.30.3-0.2
Number of responses in last shaping day0.40.50.9-1.00.90.40.4-0.40.80.80.5-0.6