Hub : Genes

Tmem216

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Tmem216	0.14	0.07	1.7e-05	0.03	0.04	0.05	0.04	6.0e-04	3.0e-05	3.8e-06	9.2e-06
2	Adipose	gene expression	Tmem216	0.13	0.07	1.6e-03	0	0	0.01	0	2.1e-01	8.6e-02	1.2e-02	1.8e-01
3	Adipose	mRNA stability	Tmem216	0.16	0.09	4.4e-03	0.02	0.01	0.02	0.01	2.2e-03	3.1e-02	5.6e-03	9.8e-03
4	PL	mRNA stability	Tmem216	0.06	0.03	1.5e-06	0.03	0.05	0.05	0.05	1.2e-04	1.2e-06	4.1e-06	8.3e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.2	0.3	1.0	-0.5	-1.0	-0.0	0.2
Area under the delay curve	0.2	0.2	0.6	0.1	0.1	0.8	0.2
BMI with tail	3.2	10.2	13.5	-3.6	-2.6	-2.8	3.7
BMI without tail	1.0	2.0	3.9	-1.4	-0.6	-1.3	2.0
Body weight	2.9	12.3	16.3	-3.6	-2.6	-3.7	4.0
Weight adjusted by age	4.2	4.8	6.3	-2.5	-1.5	-2.2	2.4
Bone surface	0.7	1.3	2.4	-1.3	-1.5	-0.4	0.9
Bone volume	0.6	1.0	2.6	-0.9	-1.6	-0.3	0.4
Breakpoint value in progressive ratio session	1.6	1.8	3.1	-1.4	-0.6	-1.7	1.3
Number of licking bursts	0.1	0.2	0.2	-0.3	-0.5	-0.5	0.3
Context. condit. distance diff. score	0.1	0.1	0.1	-0.2	-0.0	-0.3	0.3
Locomotion velocity, session 1	0.0	0.1	0.2	-0.1	0.4	0.1	0.1
Locomotion distance, session 1	0.7	0.9	1.4	-1.0	-0.3	-1.2	1.0
Locomotion velocity, session 2	2.4	2.9	3.9	-2.0	-1.3	-1.5	1.9
Locomotion distance, session 2	0.7	1.0	2.2	-0.8	0.3	-1.5	1.0
Locomotion velocity, session 3	1.5	1.8	2.4	-1.5	-1.5	-0.8	1.4
Locomotion distance, session 3	0.1	0.2	0.4	0.4	-0.1	0.6	-0.3
Stereotopy head waving bouts, day 3	0.1	0.1	0.3	-0.5	-0.0	0.0	0.5
Stereotopy head waving duration, day 3	0.2	0.2	0.6	-0.5	-0.0	-0.2	0.8
Locomotion velocity, session 7	0.0	0.0	0.1	-0.1	-0.1	0.4	0.1
Locomotion distance, session 7	0.1	0.2	0.3	0.3	0.6	0.4	0.0
Stereotopy head waving bouts, day 7	0.4	0.4	0.6	-0.8	-0.6	-0.5	0.7
Stereotopy head waving duration, day 7	1.2	1.4	1.8	-1.3	-1.1	-1.0	1.3
Locomotion velocity, session 8	0.5	0.6	1.6	0.7	1.3	-0.3	-0.3
Locomotion distance, session 8	0.1	0.2	0.4	-0.4	0.0	-0.6	0.5
Degree of sensitization distance	0.6	0.6	1.0	-1.0	-0.2	-0.7	1.0
Degree of sensitization stereotypy	1.2	1.4	1.7	-1.3	-1.2	-1.1	1.1
Conditioned locomotion	0.3	0.3	0.9	-0.6	-0.0	-0.0	0.9
Cocaine response after cond. corrected	0.2	0.2	0.5	0.2	0.7	-0.2	0.2
Cocaine response after cond. not corrected	0.0	0.0	0.0	-0.0	0.2	0.0	-0.1
Cocaine response before conditioning	0.6	0.7	1.9	-0.7	-1.4	0.2	-0.5
Saline control response	1.1	1.4	2.5	-1.1	-0.5	-1.6	1.3
Bone: connectivity density	0.7	1.1	1.7	-1.3	-1.3	-0.3	1.1
Bone: cortical apparent density	0.1	0.2	0.2	-0.5	-0.4	-0.4	0.3
Bone: cortical area	0.3	0.4	1.0	-0.7	-1.0	-0.5	0.1
Bone: cortical porosity	0.1	0.1	0.4	0.3	0.6	0.0	0.0
Bone: cortical porosity	0.2	0.2	0.5	0.2	0.7	-0.2	0.3
Bone: cortical thickness	0.4	0.7	1.7	-0.8	-0.1	-1.3	0.7
Bone: cortical thickness	0.0	0.1	0.2	0.1	-0.2	0.4	-0.1
Bone: cortical tissue density	0.2	0.2	0.3	-0.5	-0.4	-0.5	0.4
Condit. Reinf. active minus inactive responses	1.0	1.2	1.7	-1.3	-0.9	-1.2	0.9
Condit. Reinf. active-inactive response ratio	0.3	0.4	0.7	-0.7	-0.0	-0.9	0.5
Condit. Reinf. active responses	1.7	2.1	3.3	-1.8	-1.6	-1.2	1.1
Condit. Reinf. inactive responses	0.7	0.9	1.9	-1.0	-1.4	-0.4	0.5
Incentive salience index mean	0.9	1.1	1.9	-1.4	-1.2	-0.7	0.8
Condit. Reinf. lever presses	0.4	0.6	1.3	-0.9	-1.2	0.3	0.3
Condit. Reinf. active minus inactive responses	0.1	0.2	0.4	-0.2	-0.6	0.3	-0.3
Condit. Reinf. active-inactive response ratio	0.8	0.9	1.7	-1.0	-1.3	-0.5	0.7
Condit. Reinf. active responses	0.1	0.2	0.4	-0.3	-0.6	0.2	-0.2
Condit. Reinf. inactive responses	0.6	0.8	1.5	0.9	0.4	0.9	-1.2
Condit. Reinf. lever presses	1.8	2.5	3.9	-1.7	-2.0	-1.3	1.1
Condit. Reinf. lever reinforcers received	0.2	0.4	0.8	-0.7	-0.9	-0.3	0.2
Conditioned reinforcement - actives	1.0	1.0	1.7	0.8	0.3	1.3	-1.2
Conditioned reinforcement - inactives	0.3	0.3	0.6	-0.1	-0.8	0.7	-0.5
Conditioned locomotion	0.6	0.8	1.7	0.6	-0.2	1.3	-1.0
Patch foraging indifference point 0 sec	0.1	0.2	0.4	-0.6	-0.2	-0.5	0.6
Patch foraging indifference point AUC	1.1	1.3	1.9	-1.4	-1.1	-1.1	0.9
Delay disc. indifference point, 0s delay	0.2	0.2	0.5	-0.2	-0.3	0.3	0.7
Delay disc. indifference point, 16s delay	0.2	0.2	0.5	-0.4	-0.7	0.1	0.3
Delay disc. indifference point, 2s delay	0.2	0.2	0.6	0.2	-0.1	0.8	-0.3
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	0.2	0.2	0.4	-0.0
Delay disc. indifference point, 4s delay	0.1	0.1	0.3	0.1	0.2	0.3	0.5
Delay disc. indifference point, 8s delay	1.0	1.0	1.5	1.1	1.2	1.2	-0.3
Indifference point function ln k	0.7	1.0	1.4	1.2	0.7	1.1	-0.9
Indifference point function log k	0.7	1.0	1.4	1.2	0.7	1.1	-0.9
Patch foraging total patch changes 0 sec	0.1	0.1	0.2	-0.3	0.0	-0.3	0.4
Patch foraging total patch changes 12 sec	3.0	3.9	4.9	-2.2	-1.2	-2.1	2.2
Patch foraging total patch changes 18 sec	0.1	0.1	0.3	-0.3	0.2	-0.5	0.2
Patch foraging total patch changes 24 sec	4.8	5.9	7.7	-2.8	-1.8	-2.3	2.8
Patch foraging total patch changes 6 sec	0.4	0.5	0.8	-0.9	-0.7	-0.6	0.8
Patch foraging time to switch 0 sec	0.5	0.8	1.2	-1.1	-1.0	-0.3	0.9
Patch foraging water rate 0 sec	0.7	1.2	1.9	1.3	0.8	0.7	-1.4
Patch foraging water rate 12 sec	1.0	1.6	2.6	1.6	1.4	0.5	-1.3
Patch foraging water rate 18 sec	0.8	1.1	1.6	1.3	0.7	1.1	-1.0
Patch foraging water rate 24 sec	0.8	1.2	1.9	1.4	1.1	0.7	-1.1
Patch foraging water rate 6 sec	1.1	1.6	2.6	1.6	1.4	0.7	-1.2
Seeking ratio, delayed vs. immediate footshock	0.3	0.3	0.4	-0.5	-0.7	-0.6	0.5
Distance traveled before self-admin	2.0	2.2	2.8	-1.5	-1.4	-1.7	1.3
Distance traveled after self-admin	0.3	0.4	0.9	-0.5	-0.9	-0.5	0.3
Extensor digitorum longus weight	5.5	21.6	27.1	-4.9	-3.4	-4.8	5.2
Bone: elastic displacement	1.8	2.0	3.5	1.5	1.9	1.0	-1.2
Bone: elastic work	0.3	0.4	0.8	0.1	0.9	-0.8	0.3
Bone: endosteal estimation	0.2	0.4	0.7	0.1	-0.9	0.8	-0.6
Bone: endosteal perimeter	0.5	1.0	2.0	0.1	-1.4	1.2	-0.7
Epididymis fat weight	0.1	0.2	0.6	-0.0	-0.8	-0.1	-0.1
Delta time in closed arm before/after self-admin	2.6	2.6	5.1	-1.2	0.3	-2.3	1.9
Delta time in open arm before/after self-admin	1.5	1.4	2.4	-1.5	-1.4	-0.5	1.0
Diff in mean of infusions in LGA sessions	1.1	1.2	1.7	-1.3	-0.4	-1.3	1.1
Delay discount exponential model param	0.2	0.2	0.7	-0.2	-0.1	-0.8	-0.1
Extinction: sum of active levers before priming	1.8	1.8	2.7	-1.6	-0.6	-1.4	1.6
Active lever presses in extinction session 6	1.0	0.9	1.5	-1.2	-0.5	-1.1	0.9
Bone: final force	1.0	1.6	2.1	-1.5	-1.3	-1.2	1.1
Bone: final moment	0.9	1.4	1.9	-1.4	-1.2	-1.1	1.0
Food consumed during 24 hour testing period	0.5	0.6	1.0	0.8	0.3	0.7	-1.0
Glucose	1.3	2.0	2.4	1.5	1.2	1.4	-1.5
Heart weight	0.3	0.4	0.7	0.9	0.6	0.8	-0.2
Delay discount hyperbolic model param	0.2	0.2	0.6	-0.2	-0.0	-0.8	-0.1
Intermittent access intake day 1-15 change	1.1	1.1	2.5	1.1	0.5	0.8	-1.6
Intermittent access intake escalation	0.5	0.5	1.4	0.7	0.3	0.4	-1.2
Intermittent access intake escalation 2	0.1	0.1	0.2	-0.0	-0.2	-0.2	-0.5
Intermitt. access day 1 inactive lever presses	0.3	0.3	0.7	0.0	-0.8	0.8	-0.3
Intermitt. access day 15 inactive lever presses	1.6	1.7	4.4	-1.3	-2.1	-0.5	0.7
Intermitt. access escalation Index	0.5	0.4	1.1	0.7	0.3	1.0	-0.4
Intermittent access day 1 total infusions	0.5	0.6	1.8	-0.6	-1.4	0.4	0.4
Intermittent access day 15 total infusions	1.1	1.2	2.0	0.8	-0.4	1.4	-1.4
Intermittent access terminal intake (last 3 days)	0.4	0.5	1.5	-0.5	-1.2	0.2	-0.2
Intermittent access total infusions	0.4	0.4	1.2	-0.3	-1.1	0.6	-0.2
Intermittent access day 1 locomotion	1.0	1.1	2.4	-1.0	-1.6	0.1	0.9
Intermittent access day 15 total locomotion	1.3	1.4	3.2	-1.3	-1.8	-0.3	0.8
Intermittent access total locomotion	2.2	2.5	6.4	-1.7	-2.5	-0.2	0.9
Intermittent access standard deviation	0.2	0.2	0.5	0.4	0.5	-0.1	-0.7
Left kidney weight	0.2	0.5	1.3	-0.5	-1.1	-0.0	0.6
Right kidney weight	0.2	0.6	1.2	-0.8	-1.1	-0.4	0.7
Cocaine induced anxiety	0.4	0.5	0.7	-0.8	-0.6	-0.7	0.6
Post-drug Anxiety	0.9	1.0	1.4	-1.2	-0.7	-1.1	0.9
Baseline Anxiety	0.6	0.7	1.0	-0.9	-0.2	-1.0	1.0
Tail length	0.3	0.8	2.1	-0.3	0.2	-1.4	1.0
Length with tail	1.5	5.5	7.7	-2.1	-1.8	-2.8	2.5
Length without tail	1.5	3.4	3.8	-1.9	-1.8	-2.0	1.7
Times rat made contact with spout	0.1	0.1	0.2	0.2	0.4	-0.3	0.0
Lifetime Intake	0.2	0.2	0.6	-0.2	-0.8	0.6	-0.0
Liver weight, left	1.0	1.6	2.1	1.4	1.3	0.9	-1.3
Liver weight, right	0.1	0.2	0.3	0.3	0.5	-0.4	-0.5
Locomotor activity	1.6	2.5	4.2	1.7	2.0	0.8	-1.5
Locomotor testing distance	1.4	2.4	4.1	1.6	2.0	1.0	-1.4
Locomotor testing rearing	1.0	1.5	2.0	1.2	1.4	0.8	-1.4
Locomotion in novel chamber	0.8	1.0	1.9	0.9	-0.0	1.0	-1.4
Locomotion in novel chamber post-restriction	1.5	1.8	2.4	1.6	1.4	1.1	-1.2
Fecal boli incidents, locomotor time 1	1.0	1.0	2.1	-1.1	-1.4	-1.0	0.1
Change in fecal boli incidents, locomotor task	2.0	1.9	2.8	1.7	1.6	1.2	-0.7
Time >=10cm from walls, locomotor time 1	0.5	0.5	1.1	-0.2	-1.0	1.0	-0.4
Bouts of movement, locomotor time 1	1.6	1.7	4.2	-1.2	-0.8	-2.1	0.7
Total resting periods, locomotor time 1	1.4	1.6	3.2	-1.2	-1.1	-1.8	0.6
Rest time, locomotor task time 1	0.1	0.1	0.3	0.4	-0.2	0.1	-0.6
Distance moved, locomotor task time 1	0.1	0.2	0.3	0.0	0.5	0.6	0.3
Vertical activity count, locomotor time 1	3.3	3.4	5.4	1.8	1.8	2.3	-1.3
Time >=10cm from walls, locomotor time 2	0.3	0.3	0.5	0.3	-0.3	0.7	-0.6
Bouts of movement, locomotor time 2	4.7	5.0	6.3	-2.5	-1.7	-2.5	2.2
Total resting periods, locomotor time 2	4.3	4.6	5.9	-2.4	-1.7	-2.3	2.1
Rest time, locomotor task time 2	0.2	0.3	0.4	0.6	0.5	0.3	-0.6
Distance moved, locomotor task time 2	0.3	0.3	0.6	0.5	0.5	0.8	-0.4
Vertical activity count, locomotor time 2	3.8	4.1	6.8	2.1	2.6	1.8	-1.4
Light reinforcement 1	0.3	0.5	1.1	0.5	-0.1	0.8	-1.0
Light reinforcement 2	0.8	1.1	3.0	-0.2	-1.7	1.0	-0.6
Bone: marrow area	0.2	0.4	0.8	0.2	-0.7	0.9	-0.7
Bone: maximum diameter	0.4	0.8	2.2	-0.9	-1.5	-0.4	0.3
Bone: maximum force	2.1	3.7	5.6	-2.2	-2.4	-1.3	1.6
Bone: maximum moment	1.9	3.2	4.8	-2.0	-2.2	-1.3	1.5
Mean time between licks in bursts	0.3	0.4	1.1	-0.5	0.6	-0.1	1.0
Mean num. licks in bursts	0.4	0.5	1.1	0.7	1.1	0.4	-0.5
Cd content in liver	1.6	1.8	2.5	1.4	1.1	1.2	-1.6
Co content in liver	3.2	3.7	4.8	2.2	2.1	1.5	-1.9
Cu content in liver	0.1	0.1	0.2	0.0	0.3	-0.4	0.5
Fe content in liver	0.2	0.2	0.4	-0.4	-0.4	-0.6	0.5
K content in liver	1.0	1.0	1.8	-1.2	-1.3	-0.2	0.8
Mg content in liver	0.4	0.5	0.8	-0.9	-0.8	-0.4	0.5
Mn content in liver	0.8	0.9	1.3	-1.2	-1.0	-0.3	1.2
Na content in liver	0.2	0.2	0.3	-0.6	-0.5	0.1	0.1
Rb content in liver	0.6	0.7	1.2	1.0	0.7	0.6	-1.1
Se content in liver	1.2	1.5	2.5	-1.3	-1.6	-0.6	1.2
Sr content in liver	4.3	4.0	6.5	-1.9	-0.4	-2.5	2.4
Zn content in liver	3.2	3.6	5.3	-2.3	-1.7	-1.6	1.8
Bone: minimum diameter	0.3	0.6	1.4	-0.2	-1.2	0.7	-0.6
Time in familiar zone, hab. session 1	0.4	0.4	0.8	-0.5	-0.7	-0.9	0.1
Time in novel zone, hab. session 1	1.7	1.6	2.2	1.3	1.2	1.5	-1.1
Total zone transitions, hab. session 1	0.1	0.1	0.2	-0.1	0.4	-0.5	0.3
Total locomotion distance, hab. session 1	0.3	0.4	0.5	-0.6	-0.7	-0.5	0.6
Locomotion velocity, hab. session 1	0.5	0.7	0.9	-0.9	-0.5	-1.0	0.9
Time in familiar zone, hab. session 2	0.9	1.0	1.5	1.1	0.8	0.7	-1.2
Time in novel zone, hab. session 2	0.6	0.6	0.9	-0.9	-0.5	-0.5	0.9
Total zone transitions, hab. session 2	0.2	0.3	0.6	-0.6	-0.1	-0.8	0.5
Total locomotion distance, hab. session 2	0.2	0.3	0.4	-0.6	-0.5	-0.7	0.4
Locomotion velocity, hab. session 2	0.2	0.2	0.4	-0.6	-0.5	-0.5	0.3
Novel to familiar place preference ratio	1.3	1.4	2.3	-1.2	-0.9	-0.9	1.5
Novelty place preference	1.0	1.0	1.8	-1.0	-0.8	-0.8	1.4
Time in novel zone, NPP test	1.5	1.5	2.6	-1.2	-0.9	-1.1	1.6
Total zone transitions, NPP test	0.3	0.5	1.0	-0.5	0.3	-1.0	0.7
Total locomotion distance, NPP test	0.0	0.1	0.1	0.0	0.4	-0.3	0.1
Locomotion velocity, NPP test	0.1	0.2	0.4	0.4	0.6	0.3	-0.3
Intraocular pressure	0.0	0.0	0.0	0.0	-0.2	0.0	0.0
Delta distance traveled before/after self-admin	0.9	0.9	1.2	1.0	1.0	1.1	-0.7
Delta ambulatory time before/after self-admin	1.2	1.3	1.6	1.2	1.1	1.2	-0.9
Parametrial fat weight	0.3	0.7	1.6	0.3	-1.3	0.9	-0.5
Pavlov. Cond. lever latency	0.3	0.3	0.6	0.8	0.8	-0.1	-0.2
Pavlov. Cond. magazine entry latency	1.1	1.5	2.5	-1.6	-1.6	-0.5	0.8
Pavlov. Cond. change in total contacts	0.3	0.3	0.7	-0.7	-0.8	0.2	-0.0
Pavlov. Cond. index score	0.2	0.3	0.6	-0.8	-0.8	-0.1	0.1
Pavlov. Cond. latency score	0.1	0.2	0.4	-0.5	-0.6	0.1	-0.1
Pavlov. Cond. lever contacts	0.2	0.2	0.4	-0.2	-0.4	0.6	-0.3
Pavlov. Cond. magazine entry number	0.5	0.6	1.2	1.0	1.1	0.3	-0.4
Pavlov. Cond. intertrial magazine entries	0.3	0.3	0.5	0.5	0.6	-0.4	-0.7
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.8	-0.9	-0.8	-0.2	0.2
Pavlov. Cond. response bias	0.6	0.7	1.4	-1.1	-1.2	-0.0	0.4
Pavlov. Cond. lever latency	2.3	3.1	5.3	2.0	2.3	1.2	-1.3
Pavlov. Cond. magazine entry latency	7.1	8.2	10.7	-3.3	-3.0	-2.6	2.5
Pavlov. Cond. change in total contacts	3.7	5.1	8.4	-2.6	-2.9	-1.8	1.4
Pavlov. Cond. index score	7.0	9.0	12.3	-3.3	-3.5	-2.7	2.4
Pavlov. Cond. latency score	7.0	8.7	12.0	-3.3	-3.5	-2.6	2.3
Pavlov. Cond. lever contacts	2.1	2.9	3.8	-1.9	-1.9	-1.7	1.2
Pavlov. Cond. magazine entry number	11.6	14.2	17.3	4.2	3.8	3.6	-3.5
Pavlov. Cond. intertrial magazine entries	2.5	3.2	3.9	2.0	1.9	1.3	-1.9
Pavlov. Cond. lever-magazine prob. diff.	7.4	9.4	12.4	-3.4	-3.5	-2.8	2.4
Pavlov. Cond. response bias	3.8	5.2	6.9	-2.6	-2.6	-2.0	1.8
Time in closed arm before self-admin	0.3	0.3	1.0	-0.2	-1.0	0.3	-0.3
Time in closed arm after self-admin	0.1	0.1	0.2	0.4	0.3	-0.5	-0.2
Time in open arm before self-admin	3.6	3.9	7.6	2.2	2.7	1.2	-1.2
Time in open arm after self-admin	0.7	0.7	1.5	0.7	1.2	0.8	-0.4
Bone: periosteal estimation	0.3	0.6	2.0	-0.6	-1.4	-0.0	-0.1
Bone: periosteal perimeter	0.2	0.3	1.0	-0.4	-1.0	-0.2	-0.2
Bone: post-yield work	1.0	1.4	4.5	-0.8	-2.1	0.6	-0.0
Progressive ratio test 1 active lever presses	0.9	0.9	1.8	0.9	0.3	1.4	-1.1
Progressive ratio test 1 breakpoint	1.1	1.1	1.9	1.0	0.5	1.4	-1.2
Progressive ratio test 1 inactive lever presses	0.9	1.0	1.4	-1.2	-0.9	-0.6	1.1
Progressive ratio test 2 active lever presses	0.6	0.6	1.3	0.4	-0.4	1.1	-0.9
Progressive ratio test 2 breakpoint	1.1	1.3	2.3	0.9	-0.2	1.5	-1.4
Progressive ratio test 2 inactive lever presses	0.5	0.6	1.8	-0.6	-1.3	0.3	-0.0
Incentive Sensitization - Responses	0.3	0.3	1.0	-0.5	-1.0	0.1	0.2
Incentive Sensitization - Breakpoint	0.4	0.4	1.3	-0.5	-1.1	0.2	0.1
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.6	-0.8	-0.4	-0.5	0.3
Progressive ratio	0.2	0.2	0.5	-0.3	-0.7	0.1	0.3
Food seeking constrained by brief footshock	0.3	0.4	0.7	0.7	0.5	0.8	-0.3
Seeking ratio, punishment vs. effort	0.3	0.4	1.1	0.6	1.0	0.2	-0.3
Retroperitoneal fat weight	0.9	2.8	4.3	2.1	0.8	1.7	-1.9
Reaction time number correct	0.5	0.7	2.7	-0.0	0.1	-1.6	0.3
Reaction time mean minus median	0.3	0.5	0.9	-0.8	-0.4	-0.9	0.5
Reaction time mean minus median AUC	0.2	0.3	1.0	-0.2	0.1	-1.0	0.0
Reaction time num false alarms	0.8	1.1	2.4	1.3	1.6	0.3	-0.7
Reaction time num false alarms AUC	0.8	1.1	2.9	1.2	1.7	0.2	-0.4
Reaction time trials correct on left	0.5	0.7	2.7	-0.0	0.1	-1.6	0.3
Reaction time trials on left	0.5	0.7	2.8	0.0	0.2	-1.7	0.3
Reaction time mean	0.1	0.2	0.3	-0.6	-0.4	-0.4	-0.1
Reaction time mean AUC	0.1	0.1	0.2	-0.4	-0.4	-0.3	-0.3
Median of all reaction times	0.3	0.4	0.7	-0.8	-0.8	-0.5	0.2
Reaction time omissions	0.3	0.3	0.6	0.4	0.8	-0.7	-0.2
Reaction time false alarm rate	0.7	1.0	1.6	1.0	1.3	1.0	-0.5
Reaction time premature initiation rate	2.2	2.9	4.1	-2.0	-1.8	-0.7	2.0
Reaction time premature initiations	2.3	3.2	4.1	-1.9	-1.4	-1.8	2.0
Std. dev. reaction times	0.1	0.1	0.2	0.1	0.4	-0.5	-0.4
Reaction time trials completed	0.5	0.7	2.8	0.0	0.2	-1.7	0.3
Reaction time trials AUC	0.5	0.7	2.7	0.1	0.3	-1.6	0.2
Run reversals in cocaine runway, females	0.4	0.4	0.7	-0.7	-0.4	-0.4	0.8
Run reversals in cocaine runway, males	3.1	3.0	3.9	1.7	1.5	2.0	-1.7
Latency to leave start box in cocaine runway	0.4	0.4	0.7	0.3	-0.8	0.8	-0.3
Latency to leave start box in cocaine runway, F	0.3	0.3	0.9	-0.3	-1.0	0.1	0.2
Latency to leave start box in cocaine runway, M	2.2	2.2	3.5	1.5	0.3	1.9	-1.6
Std. dev. time between licks in bursts	0.6	0.7	1.2	0.8	0.8	1.1	-0.6
Total sessions with >9 infusions	0.2	0.2	0.7	0.2	-0.1	0.8	-0.1
Short access day 1 total inactive lever presses	0.2	0.2	0.6	0.4	0.0	0.8	-0.4
Short access day 10 total inactive lever presses	1.6	1.8	2.8	1.4	1.1	1.7	-1.1
Short access day 1 total infusions	0.1	0.1	0.3	0.3	0.2	0.5	-0.1
Short access day 10 total infusions	0.7	0.8	1.8	-0.9	-1.3	0.3	0.7
Short access total infusions	0.1	0.1	0.2	-0.4	-0.5	0.2	0.4
Short access day 1 locomotion	0.8	0.8	1.1	-1.0	-1.0	-0.4	1.0
Short access day 10 total locomotion	1.5	1.7	3.0	-1.5	-1.7	-0.5	1.2
Short access total locomotion	2.3	2.4	3.4	-1.8	-1.8	-0.7	1.6
One hour access (0.3 mA shock)	1.1	1.2	2.0	1.0	-0.2	1.4	-1.4
Compulsive drug intake	0.6	0.6	1.6	0.1	1.3	-0.8	0.5
One hour access (shock baseline)	2.0	2.3	3.8	1.2	-0.4	1.9	-1.9
Social response proportion	0.2	0.2	0.4	0.6	0.1	0.4	-0.6
Social responses	0.6	0.8	1.3	1.1	0.9	0.5	-1.0
Social time	0.6	0.8	2.0	0.9	1.4	0.2	-0.5
Soleus weight	1.9	5.5	8.2	2.4	1.3	2.5	-2.9
Bone: stiffness	0.8	1.3	3.3	-1.1	-1.8	-0.5	0.6
Tibialis anterior weight	6.0	20.7	28.1	-4.6	-2.5	-5.3	5.2
Time to tail flick, vehicle, before self-admin	1.4	1.4	2.0	-1.3	-1.4	-0.5	1.2
Time to tail flick, vehicle, after self-admin	1.1	1.2	1.9	-1.0	-0.6	-1.4	1.3
Time to tail flick, test, before self-admin	0.2	0.2	0.4	-0.3	-0.1	-0.5	0.6
Time to tail flick, test, after self-admin	0.6	0.6	0.8	0.8	0.7	0.9	-0.7
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.4	0.2	0.3	-0.6	-0.0
Delta time to tail flick, test, before/after SA	0.2	0.2	0.4	0.2	0.3	0.6	-0.5
Tibia length	1.4	4.0	4.7	-2.1	-2.2	-2.0	1.7
Ambulatory time before self-admin	1.5	1.6	2.0	-1.4	-1.4	-1.2	0.9
Ambulatory time after self-admin	0.7	0.8	2.4	-0.8	-1.5	-0.3	0.3
Bone: tissue strength	0.7	0.7	1.5	0.7	0.3	1.2	-0.9
Total heroin consumption	1.4	1.6	2.7	-1.2	0.2	-1.6	1.5
Bone: trabecular number	0.7	1.1	2.1	-1.1	-1.5	-0.3	0.9
Bone: trabecular spacing	0.5	0.7	1.4	0.9	1.2	0.2	-0.8
Bone: trabecular thickness	0.2	0.2	0.5	0.3	-0.6	0.1	-0.7
Bone: trabecular tissue density	2.5	3.5	4.9	2.0	1.7	1.5	-2.2
Water consumed over 24 hours	0.1	0.1	0.4	-0.1	-0.2	-0.6	0.3
Number of responses in last shaping day	0.1	0.1	0.3	0.0	0.5	-0.1	0.2